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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MAPKAPK3-DOCK3 (FusionGDB2 ID:51615) |
Fusion Gene Summary for MAPKAPK3-DOCK3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPKAPK3-DOCK3 | Fusion gene ID: 51615 | Hgene | Tgene | Gene symbol | MAPKAPK3 | DOCK3 | Gene ID | 7867 | 1795 |
| Gene name | MAPK activated protein kinase 3 | dedicator of cytokinesis 3 | |
| Synonyms | 3PK|MAPKAP-K3|MAPKAP3|MAPKAPK-3|MDPT3|MK-3|MK3 | MOCA|NEDIDHA|PBP | |
| Cytomap | 3p21.2 | 3p21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MAP kinase-activated protein kinase 3MAPKAP kinase 3chromosome 3p kinasemitogen-activated protein kinase-activated protein kinase 3 | dedicator of cytokinesis protein 3modifier of cell adhesionpresenilin-binding protein | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | . | Q8IZD9 | |
| Ensembl transtripts involved in fusion gene | ENST00000357955, ENST00000446044, ENST00000497283, | ENST00000266037, | |
| Fusion gene scores | * DoF score | 3 X 1 X 3=9 | 12 X 10 X 7=840 |
| # samples | 3 | 12 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/840*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAPKAPK3 [Title/Abstract] AND DOCK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MAPKAPK3(50655215)-DOCK3(50927457), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAPKAPK3 | GO:0018105 | peptidyl-serine phosphorylation | 15850461 |
| Hgene | MAPKAPK3 | GO:0034097 | response to cytokine | 8774846 |
| Fusion gene breakpoints across MAPKAPK3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DOCK3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-58-A46L | MAPKAPK3 | chr3 | 50655215 | + | DOCK3 | chr3 | 50927457 | + |
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Fusion Gene ORF analysis for MAPKAPK3-DOCK3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000357955 | ENST00000266037 | MAPKAPK3 | chr3 | 50655215 | + | DOCK3 | chr3 | 50927457 | + |
| In-frame | ENST00000446044 | ENST00000266037 | MAPKAPK3 | chr3 | 50655215 | + | DOCK3 | chr3 | 50927457 | + |
| intron-3CDS | ENST00000497283 | ENST00000266037 | MAPKAPK3 | chr3 | 50655215 | + | DOCK3 | chr3 | 50927457 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000446044 | MAPKAPK3 | chr3 | 50655215 | + | ENST00000266037 | DOCK3 | chr3 | 50927457 | + | 9385 | 815 | 596 | 6745 | 2049 |
| ENST00000357955 | MAPKAPK3 | chr3 | 50655215 | + | ENST00000266037 | DOCK3 | chr3 | 50927457 | + | 8898 | 328 | 109 | 6258 | 2049 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000446044 | ENST00000266037 | MAPKAPK3 | chr3 | 50655215 | + | DOCK3 | chr3 | 50927457 | + | 0.000959173 | 0.9990408 |
| ENST00000357955 | ENST00000266037 | MAPKAPK3 | chr3 | 50655215 | + | DOCK3 | chr3 | 50927457 | + | 0.000645556 | 0.9993544 |
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Fusion Genomic Features for MAPKAPK3-DOCK3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MAPKAPK3-DOCK3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:50655215/chr3:50927457) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | DOCK3 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000357955 | + | 2 | 11 | 50_58 | 73 | 383.0 | Nucleotide binding | ATP |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000446044 | + | 4 | 13 | 50_58 | 73 | 383.0 | Nucleotide binding | ATP |
| Tgene | DOCK3 | chr3:50655215 | chr3:50927457 | ENST00000266037 | 2 | 53 | 1731_1768 | 54 | 2031.0 | Compositional bias | Note=Ser-rich | |
| Tgene | DOCK3 | chr3:50655215 | chr3:50927457 | ENST00000266037 | 2 | 53 | 1228_1635 | 54 | 2031.0 | Domain | DOCKER | |
| Tgene | DOCK3 | chr3:50655215 | chr3:50927457 | ENST00000266037 | 2 | 53 | 421_599 | 54 | 2031.0 | Domain | C2 DOCK-type | |
| Tgene | DOCK3 | chr3:50655215 | chr3:50927457 | ENST00000266037 | 2 | 53 | 1970_1976 | 54 | 2031.0 | Motif | SH3-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000357955 | + | 2 | 11 | 44_304 | 73 | 383.0 | Domain | Protein kinase |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000446044 | + | 4 | 13 | 44_304 | 73 | 383.0 | Domain | Protein kinase |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000357955 | + | 2 | 11 | 335_344 | 73 | 383.0 | Motif | Nuclear export signal (NES) |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000357955 | + | 2 | 11 | 350_353 | 73 | 383.0 | Motif | Bipartite nuclear localization signal 1 |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000357955 | + | 2 | 11 | 364_368 | 73 | 383.0 | Motif | Bipartite nuclear localization signal 2 |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000446044 | + | 4 | 13 | 335_344 | 73 | 383.0 | Motif | Nuclear export signal (NES) |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000446044 | + | 4 | 13 | 350_353 | 73 | 383.0 | Motif | Bipartite nuclear localization signal 1 |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000446044 | + | 4 | 13 | 364_368 | 73 | 383.0 | Motif | Bipartite nuclear localization signal 2 |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000357955 | + | 2 | 11 | 307_343 | 73 | 383.0 | Region | Autoinhibitory helix |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000357955 | + | 2 | 11 | 345_369 | 73 | 383.0 | Region | p38 MAPK-binding site |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000446044 | + | 4 | 13 | 307_343 | 73 | 383.0 | Region | Autoinhibitory helix |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50927457 | ENST00000446044 | + | 4 | 13 | 345_369 | 73 | 383.0 | Region | p38 MAPK-binding site |
| Tgene | DOCK3 | chr3:50655215 | chr3:50927457 | ENST00000266037 | 2 | 53 | 6_67 | 54 | 2031.0 | Domain | SH3 |
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Fusion Gene Sequence for MAPKAPK3-DOCK3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >51615_51615_1_MAPKAPK3-DOCK3_MAPKAPK3_chr3_50655215_ENST00000357955_DOCK3_chr3_50927457_ENST00000266037_length(transcript)=8898nt_BP=328nt CTGCGGCCGCCAGCTCCCGCGACCGCCTCTCCTGCCCCTCGCCGGTACCTCAGCAAGGTGCCACTAGAAGCGCCAGGCTGGGGCCGCCTC TGAGCGCCCCGCGGGGGCCATGGATGGTGAAACAGCAGAGGAGCAGGGGGGCCCTGTGCCCCCGCCAGTTGCACCCGGCGGACCCGGCTT GGGCGGTGCTCCGGGGGGGCGGCGGGAGCCCAAGAAGTACGCAGTGACCGACGACTACCAGTTGTCCAAGCAGGTGCTGGGCCTGGGTGT GAACGGCAAAGTGCTGGAGTGCTTCCATCGGCGCACTGGACAGAAGTGTGCCCTGAAGGGGATCTTTCCTGCAAATTACATTCACTTGAA AAAGGCAATTGTCAGTAATAGGGGGCAGTATGAAACTGTGGTTCCACTTGAAGATTCTATTGTGACTGAGGTTACAGCAACTCTACAAGA ATGGGCAAGTTTGTGGAAACAGTTGTATGTGAAACACAAAGTAGATCTTTTCTACAAACTACGCCATGTGATGAATGAACTTATTGACCT GCGAAGGCAGCTACTGTCTGGTCACCTGACTCAGGATCAGGTGCGGGAGGTTAAGCGGCACATCACCGTGCGCCTGGACTGGGGTAATGA ACATTTGGGCCTGGACCTGGTGCCTCGGAAGGACTTTGAAGTAGTGGACTCGGACCAGATTAGTGTCTCAGATCTCTATAAGATGCATTT ATCTAGCCGGCAGAGTGTACAGCAAAGCACATCCCAGGTAGATACAATGCGCCCACGTCATGGGGAAACATGTCGGATGCCAGTGCCACA TCACTTCTTCCTCAGCCTGAAGAGTTTCACTTACAATACTATTGGGGAAGATACCGATGTCTTCTTTTCCTTATATGACATGAGGGAAGG CAAGCAGATCAGTGAGCGGTTTCTGGTAAGACTGAACAAGAATGGTGGGCCGAGGAACCCAGAGAAGATAGAACGAATGTGTGCCCTTTT TACAGATCTGAGCAGCAAAGATATGAAGAGAGATTTGTATATCGTTGCCCATGTGATCCGAATAGGCCGGATGCTCCTGAACGACTCAAA GAAAGGTCCTCCTCACCTGCACTACAGGCGACCATATGGCTGTGCGGTCCTAAGCATCTTGGATGTCCTACAGTCACTCACAGAAGTAAA GGAAGAAAAGGATTTTGTTCTTAAGGTTTACACGTGCAACAACGAGAGTGAGTGGTCCCAGATCCACGAGAACATCATCCGAAAGTCCAG TGCCAAGTACTCTGCCCCCAGCGCCAGCCATGGTCTTATCATTTCTCTGCAGCTTCTTCGTGGAGACATGGAACAGATTCGGAGAGAAAA TCCCATGATATTTAATAGGGGATTGGCAATTACAAGAAAATTGGGATTTCCTGATGTCATTATGCCAGGTGATATCCGCAATGACCTGTA CCTAACCCTGGAGAAGGGGGATTTCGAGAGAGGAGGAAAGAGTGTACAAAAGAATATTGAAGTGACCATGTATGTGCTTTATGCAGATGG AGAAATCTTGAAGGATTGCATCAGCTTGGGTTCAGGAGAGCCAAATAGGAGTTCCTACCACTCCTTTGTCCTCTACCACAGTAATAGTCC TCGCTGGGGAGAAATTATCAAATTGCCTATCCCCATTGACCGGTTCCGGGGCTCCCACCTGCGCTTTGAGTTCAGACATTGTTCCACAAA GGACAAAGGGGAAAAGAAACTCTTTGGCTTTGCATTCTCAACCCTGATGCGTGATGATGGCACCACCCTCTCAGATGATATTCACGAGCT TTATGTGTACAAGTGTGATGAGAATAGCACGTTTAATAACCATGCTCTGTACCTGGGCCTGCCCTGCTGCAAAGAGGACTACAATGGCTG CCCTAATATTCCTTCTAGCCTCATCTTCCAGCGCAGCACCAAAGAGTCTTTCTTCATCTCCACTCAGCTCTCCTCTACCAAACTCACCCA GAATGTGGACCTCCTAGCTCTGCTGAAGTGGAAAGCCTTCCCCGACCGGATCATGGATGTACTAGGGCGGCTGCGGCATGTCAGTGGGGA GGAAATTGTTAAGTTTCTGCAGGACATCTTAGATACACTCTTTGTGATTTTGGATGATAATACAGAGAAGTACGGCCTGTTGGTTTTTCA GTCTCTGGTGTTCATCATCAACCTGCTCCGAGACATCAAGTATTTTCACTTTCGACCTGTGATGGACACGTATATCCAGAAGCACTTTGC TGGAGCTCTGGCATACAAGGAGCTCATCCGCTGTTTGAAGTGGTATATGGACTGCTCAGCAGAACTGATTCGACAGGACCACATTCAAGA AGCTATGCGGGCCTTGGAGTACCTTTTCAAGTTCATTGTACAGTCACGGATCCTGTACTCACGAGCCACTTGTGGAATGGAAGAGGAACA ATTCAGATCCAGTATCCAAGAACTTTTCCAGTCCATCCGGTTTGTGCTCAGTCTGGACAGCCGAAACTCAGAAACACTCCTTTTTACTCA GGCTGCACTCCTCAATTCTTTCCCAACCATCTTTGATGAGCTTCTGCAAATGTTCACCGTGCAAGAGGTGGCAGAGTTTGTGAGAGGGAC ACTGGGGAGCATGCCCAGCACTGTGCACATTGGGCAGTCAATGGACGTGGTCAAGCTGCAGTCCATTGCCAGGACAGTGGATAGCCGCCT GTTTTCTTTCTCAGAATCCCGCCGCATCCTGCTTCCTGTGGTTCTCCATCACATTCACCTTCACCTGAGGCAGCAGAAAGAGCTGCTAAT TTGCTCAGGGATTCTTGGCAGCATCTTCTCCATCGTCAAGACCAGCTCTCTGGAGGCAGATGTCATGGAGGAAGTAGAGATGATGGTGGA GAGCCTCCTGGACGTGCTCTTGCAGACTCTGCTCACCATCATGAGCAAATCGCACGCTCAGGAGGCGGTAAGAGGGCAGCGGTGCCCGCA GTGCACAGCCGAGATCACTGGCGAGTATGTGTCCTGCCTTCTCTCACTGCTCCGCCAGATGTGTGACACCCATTTCCAGCACCTCCTGGA CAACTTCCAGAGCAAAGATGAACTCAAGGAATTTCTGCTGAAGATTTTTTGCGTGTTCCGGAACCTGATGAAGATGAGTGTCTTCCCTCG GGACTGGATGGTAATGAGACTGCTCACAAGCAATATTATAGTCACTACTGTCCAGTACCTGTCCTCTGCACTGCACAAGAATTTCACAGA GACTGACTTTGACTTTAAGGTGTGGAATTCTTACTTTAGCCTGGCAGTTCTATTCATAAATCAGCCAAGCCTTCAGCTAGAAATTATCAC CTCAGCCAAAAGGAAGAAGATTCTAGATAAGTATGGGGACATGCGTGTAATGATGGCCTATGAACTGTTCAGCATGTGGCAGAATTTGGG TGAACATAAGATCCACTTTATTCCGGGAATGATTGGTCCTTTTCTGGGTGTGACACTGGTCCCACAGCCAGAAGTACGGAATATCATGAT TCCCATCTTTCATGACATGATGGACTGGGAGCAGAGAAAAAATGGCAACTTCAAACAGGTGGAGGCCGAGTTGATTGACAAGCTGGACAG CATGGTGTCAGAAGGGAAAGGTGACGAGAGCTACAGGGAGCTCTTCAGCCTACTAACCCAGCTGTTTGGGCCCTACCCCAGCCTGCTGGA GAAGGTTGAACAAGAAACATGGCGCGAGACCGGCATTTCCTTTGTGACCTCAGTCACCCGCCTCATGGAACGTCTTCTTGACTACAGGGA CTGCATGAAAGGAGAGGAAACAGAGAATAAGAAGATAGGCTGCACTGTTAACCTGATGAATTTTTACAAATCTGAGATTAACAAGGAAGA AATGTATATCCGCTACATCCATAAGCTTTGTGACATGCACTTGCAGGCCGAAAACTACACAGAGGCCGCATTTACCCTGCTCCTTTACTG TGAGCTGCTGCAGTGGGAGGACCGGCCACTACGGGAATTCCTCCACTACCCATCGCAGACAGAGTGGCAGCGGAAGGAGGGACTGTGCCG GAAGATCATTCACTACTTCAACAAAGGCAAGAGCTGGGAGTTTGGGATCCCACTGTGCAGGGAGCTGGCGTGTCAGTACGAGAGCCTCTA TGATTACCAGAGCCTCAGCTGGATTCGGAAAATGGAGGCCAGCTACTATGACAACATTATGGAGCAGCAACGCCTGGAGCCTGAGTTCTT TCGGGTCGGCTTCTATGGCAGGAAGTTTCCTTTCTTTCTTCGGAACAAAGAATACGTGTGCCGTGGCCATGACTACGAGAGGCTGGAGGC CTTCCAGCAGAGGATGCTCAGTGAGTTTCCGCAGGCTGTCGCCATGCAGCACCCCAACCATCCTGATGACGCCATCCTACAGTGCGATGC CCAGTACTTGCAGATCTATGCAGTGACGCCCATTCCAGATTATGTGGATGTTCTGCAGATGGATAGGGTACCAGATCGAGTCAAGAGCTT CTATCGCGTCAACAATGTGAGGAAGTTCCGGTATGACAGGCCTTTTCACAAAGGCCCCAAGGACAAGGAGAATGAATTCAAGAGCCTGTG GATTGAACGTACCACACTGACCCTGACCCACAGCTTGCCTGGCATCTCTCGGTGGTTTGAAGTGGAGAGGAGGGAACTGGTGGAGGTGAG CCCTCTGGAGAATGCCATCCAAGTGGTTGAGAATAAGAACCAGGAGCTACGCTCCCTGATCAGCCAGTATCAACACAAGCAGGTGCATGG CAACATTAACCTGCTAAGCATGTGCCTGAATGGTGTCATTGATGCAGCTGTCAATGGAGGCATTGCACGCTATCAGGAGGCCTTCTTTGA TAAAGATTACATCAACAAGCACCCAGGAGATGCTGAGAAGATCACCCAGCTCAAGGAGCTTATGCAGGAGCAGGTTCATGTCCTTGGAGT TGGGCTAGCAGTTCATGAGAAGTTTGTGCACCCAGAAATGCGGCCTCTGCATAAGAAGCTAATTGATCAGTTCCAGATGATGCGGGCCAG TCTCTACCATGAGTTTCCAGGTTTGGATAAGCTAAGTCCTGCATGTTCAGGCACCAGCACCCCACGGGGAAATGTTCTGGCATCCCATAG CCCCATGAGTCCGGAGAGCATCAAGATGACCCACCGGCACAGCCCCATGAACTTGATGGGCACAGGCCGCCATTCATCATCCTCTCTCTC CTCACATGCGTCTAGTGAAGCAGGAAACATGGTGATGCTGGGTGACGGCTCCATGGGTGATGCTCCTGAGGACCTGTACCACCACATGCA GCTCGCGTATCCCAACCCCAGGTACCAAGGCTCAGTCACCAACGTCTCTGTTCTGTCCTCGTCCCAGGCAAGCCCTTCTTCCTCCAGCCT GAGTTCCACTCACTCAGCACCATCCCAGATGATTACCTCTGCCCCTTCCAGTGCCCGAGGCTCTCCCTCTCTGCCAGATAAGTACCGCCA TGCCCGTGAAATGATGTTGTTGCTGCCCACATACCGGGACCGCCCAAGCAGTGCCATGTATCCAGCAGCCATCCTGGAGAACGGACAGCC GCCGAATTTCCAGCGAGCCCTGTTCCAGCAAGTGGTCGGAGCCTGCAAACCCTGCAGTGATCCCAATCTGTCTGTGGCTGAAAAAGGTCA TTACTCCCTACACTTTGACGCCTTCCACCACCCTCTGGGTGATACCCCCCCAGCCCTCCCTGCCCGGACCCTGCGCAAGTCTCCTCTCCA CCCTATCCCAGCCTCCCCCACAAGCCCCCAGTCAGGTCTGGACGGCAGCAACTCTACGCTGTCCGGCAGTGCCAGCAGCGGCGTGTCCTC CTTGAGTGAGAGTAACTTTGGGCACTCCTCGGAGGCCCCACCTCGCACTGACACCATGGACTCCATGCCAAGTCAGGCCTGGAATGCTGA CGAAGATCTTGAGCCACCCTACCTCCCTGTCCACTACAGCCTCTCTGAGTCTGCCGTCCTGGACTCCATCAAGGCCCAGCCATGCCGAAG CCACTCAGCCCCAGGGTGCGTCATCCCTCAGGACCCCATGGACCCGCCTGCGCTGCCGCCCAAGCCCTACCACCCCCGCCTGCCGGCCCT GGAGCACGATGAGGGGGTGCTGCTGCGTGAAGAGACTGAGAGGCCTCGAGGCCTGCACCGCAAGGCTCCATTGCCTCCTGGGAGCGCTAA GGAGGAGCAGGCCCGCATGGCCTGGGAGCACGGCCGAGGGGAGCAGTGAGGGGCAACGAGGCGGCTGGGATGCCGCCCTCAGTAAGCAGC TTGCCAATCACTCCAGGTCTGAAAAGCAAGTCCCCCAGCCCCACCCCAGGGAGCCAGAGAGGCTTGCACTCAGGAGAGAACCACCCCCAA GTCTCCGTTCTACTGCCGTGAACTCATGTGTTGCCATGTACAGAGGCCACAGCAGCATGAAGGGTTGTGGCTTCCCTTTTTATTTTTTTA CATTTCCATTTCTATGGGTTTTCCTTTCTTTCCTTTATGCAGTAGATGCTTTCTTCCTCCTGCAGTTCTGGACCATGTGGAGCTACATGG AGAAATTGCACAGACAGAATCACTTTGCCACACTGCAGGGCCCAGGAGTGGGAGCCCAGGCCCTCCCTCCAGGGTAGAGATGCACCGAAT GGAAATTGCACTAAGGACCTCTTCCTTTGCTGTATGGACAGAAGAGTTCATGGTTGCATTCAGGGATTGCAAGGACCATATAGACATGTC ACAGGTGGAAAAAGGGCCACAAGCCGTTTTGCACAAATGCCTGCCCACCTGCCCCTCTTCCATCCAGGAGTGTGCTACTGAGGGGCTGGC TGGACCAACCTGCTGGCTCAGGCATGTGACTGGCCTAACTGCATGCCCAGGGCACTGCCAGGGTTCAATGGGCCAGCCGTCTCCTACTCC ACCTTGGATTTTTCTCTCCATCACATCATTTCTGACCATTTGCTCCCTTCCATTCTTGAAACACCTCATGCCCCACAGGAGCCCCAGTGG TGACTGGATCTGCAAGGGTTATCTCCCGCCCTCTGGGGTTTGAGTGGAGGTATGGAGCCAGAGAGGCTATCCTAGCTACCTTCCTCCTAG GGGGAGCTGGTCCCCTTCCTATGTGGTAGAGAGACTGGTGTAAGAGTGTGGGGTGTGGCAGGCGCCGGAAATCCTCAAAGCTTTCAGAAG CATCCAGAATGCCTACCATCAGCTCCTGAATCAGGGATTTTCAGCACTACCTCTGAGCCATGGGGTTGGCTGCCCAGCCAGGCTTCCAGG CCCTGAGGACATGTGGTCAGGTTCAGCAGGCTCCTGGGTAAAGAGGGTGGGAGGGGGCTTCTCCTTTTGGAAGCAGATAGCCATGCAGGT AGAATTGTCATCTCCCAAGTGGCCACATACAGCAACCCACTCCAGGCCATGGGGACCACCACTCAGGGTTCGGGGCTGGCAGGAGGGTAG TTTCTCCAGTCTCCCCAGTCTGTTGGTGTCTTTATAGGAAACTATAAAGCAGAGCAGTGGTGTCTTTAGAGGAAACTCATTCAAGTCAGG GCACTGATTTTCCTCTCAGTTTATTATTTGGGGGGATAGGGTCAGGTGGGTATAGTAGTACTTTACCAGGGTGCTTTTAAGTTACTTTAA AAAAAGCCTACAAAATATTTTTTTTCTTTTATTTGCTCGAGTTCACATTAATGATGGTCACAAGGCTGCCTTGTTGGGCAGGCGTATTGC CCCCAGTTCCTCTTCTGCTGGCCTGTATGACCTCCACAGCCAGGCCCTGGGCCCAAGCCCCTTGTCCCTTCTCCACTGCCCCTCTTTCCA GACAGTAAAGGCCATGGTCAGTGTGTTTTTCTCTTGTAAACAAACCCCAGCTTGTTTAACAGAAATGCTAATAACCTACTGGGAAAGATG GAGGTCTAAATTACCTCCAGGGTTTTTCTGGGGGTTTATCACCAGTGTGGGTCCCTTCTGATACCACCAGGTTCACTCCAGGCAGAGTGG GGCGGAAGGCTGCTGAGGATATGGGTCAGTTACAGCAGCCCTCACCTCAAAGGGCTGGCCTGCTTCTCAGCCTACATTCATTTGCAAGCT TCAATCTCTGGACCATCTGGTGTTCACAGGTGTTAGAGGGTTAGGGGTTAGGGGCTAGTTTTGGATTTGATTCATAGGTAGGAGGGCTTA GATTTTAAGGCACTTCTGAAAGTCAATCCCTGGACAAGGCAGTCATCACATAAGAACAGCTACCTTCTCCACTTGGTGGCACAAGAGGTA GGGAGGGGAGTATGGGTTCATTTGGCTTCGCATTATGCAAGGTGAAACCGTTTGTTTTCCCTCTCCATTTTCCCTAACTAAATGAAAAGG ACACATTCTGAAATCCCTTTTGTTGGAGAATAAGTCAGTCTGAGGGGAAATGGGAGGCCAGAGATGAGAACCCTTTGAAAAGATTGTAAA ATACTGATTTTCATTCTTTCAAGCTTATTTGTAAATACCTATTTGAATGCTGTGTATTTGTACAGGAATTTGAGCAAAAAATGTATAGAG TGTGATGTCCAATTGGTATTCAGCACTATAAATGTGTTTTTAACCTCCCGCATTCTGTGCTTATTTAAAACAAGGAAACTTCTAACCATT TCTTTTGTGTATTCATGTTTAAAGAAAAAAAGTGATTTAAAAATGATCTTACCTGTACCAGAAAAGCAAAGTTAAAGGAAACAAAATTTG TACCATTGTCCCAAGAGGTATTTTACTGTATATATTGTGGTAGCATGTTCAAAATCCAACAAGTAATGTGAATTTTAGATGTAAATATCT >51615_51615_1_MAPKAPK3-DOCK3_MAPKAPK3_chr3_50655215_ENST00000357955_DOCK3_chr3_50927457_ENST00000266037_length(amino acids)=2049AA_BP=0 MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKGIFPANYIHLKKAIVSN RGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDL VPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTMRPRHGETCRMPVPHHFFLSLKSFTYNTIGEDTDVFFSLYDMREGKQISER FLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPPHLHYRRPYGCAVLSILDVLQSLTEVKEEKDFV LKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKG DFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKK LFGFAFSTLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLA LLKWKAFPDRIMDVLGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYK ELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNS FPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILG SIFSIVKTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAVRGQRCPQCTAEITGEYVSCLLSLLRQMCDTHFQHLLDNFQSKD ELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSAKRKK ILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSMVSEGK GDESYRELFSLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYI HKLCDMHLQAENYTEAAFTLLLYCELLQWEDRPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYESLYDYQSLS WIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIY AVTPIPDYVDVLQMDRVPDRVKSFYRVNNVRKFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAI QVVENKNQELRSLISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYINKHPGDAEKITQLKELMQEQVHVLGVGLAVHE KFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPESIKMTHRHSPMNLMGTGRHSSSSLSSHASSE AGNMVMLGDGSMGDAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKYRHAREMML LLPTYRDRPSSAMYPAAILENGQPPNFQRALFQQVVGACKPCSDPNLSVAEKGHYSLHFDAFHHPLGDTPPALPARTLRKSPLHPIPASP TSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEAPPRTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPCRSHSAPGC -------------------------------------------------------------- >51615_51615_2_MAPKAPK3-DOCK3_MAPKAPK3_chr3_50655215_ENST00000446044_DOCK3_chr3_50927457_ENST00000266037_length(transcript)=9385nt_BP=815nt GGGCTGAGCGGTGGGGCCCGGGCGGGGTGCGCGGGCCCCGTCGCCGGGTCTGGGGCCCTGAGCAGTGAAAGGAAATACTTTGACAGATTT CCAAGAACTTTCCAGGAAAACGGGGCGGGGCCCCGCGAGCTGACCAATCGCGACGCTGAAGGTGGAGCCGAGCGGTCGGGGAGGGCCAAT AGCAGCGCGTGGACCCGGGGCTGAAGCTACCCAGAGGGGCAGGGAGTACTTGCTGCATTTGATCCTCTACAACTGGTGTTGCTCCCGTTA TGCGGACAGAAGACAGCCCCAGGGAACAAATGCTAGGAAATGGCAGGGTGAGAAAACTGAGGCATGGAGAGGTTACAATATAACTTAGAT CTCCCAGCTGGCAAGTAATGGTTTAAGCCAGGAGCCTACACACTTCCTCCTACTTCCTCTATGGGTGCTGGTGATCTGCCGACTCCTAGA CATCCAGCTTTAAGGTCCTCAGTGAAGCTTCTCTGCCCCCAGGCCTGTCCATGTCAGAGCACCATGGGTGTCCCTTTGAAAGTATCTCCT ACAGGTGCCACTAGAAGCGCCAGGCTGGGGCCGCCTCTGAGCGCCCCGCGGGGGCCATGGATGGTGAAACAGCAGAGGAGCAGGGGGGCC CTGTGCCCCCGCCAGTTGCACCCGGCGGACCCGGCTTGGGCGGTGCTCCGGGGGGGCGGCGGGAGCCCAAGAAGTACGCAGTGACCGACG ACTACCAGTTGTCCAAGCAGGTGCTGGGCCTGGGTGTGAACGGCAAAGTGCTGGAGTGCTTCCATCGGCGCACTGGACAGAAGTGTGCCC TGAAGGGGATCTTTCCTGCAAATTACATTCACTTGAAAAAGGCAATTGTCAGTAATAGGGGGCAGTATGAAACTGTGGTTCCACTTGAAG ATTCTATTGTGACTGAGGTTACAGCAACTCTACAAGAATGGGCAAGTTTGTGGAAACAGTTGTATGTGAAACACAAAGTAGATCTTTTCT ACAAACTACGCCATGTGATGAATGAACTTATTGACCTGCGAAGGCAGCTACTGTCTGGTCACCTGACTCAGGATCAGGTGCGGGAGGTTA AGCGGCACATCACCGTGCGCCTGGACTGGGGTAATGAACATTTGGGCCTGGACCTGGTGCCTCGGAAGGACTTTGAAGTAGTGGACTCGG ACCAGATTAGTGTCTCAGATCTCTATAAGATGCATTTATCTAGCCGGCAGAGTGTACAGCAAAGCACATCCCAGGTAGATACAATGCGCC CACGTCATGGGGAAACATGTCGGATGCCAGTGCCACATCACTTCTTCCTCAGCCTGAAGAGTTTCACTTACAATACTATTGGGGAAGATA CCGATGTCTTCTTTTCCTTATATGACATGAGGGAAGGCAAGCAGATCAGTGAGCGGTTTCTGGTAAGACTGAACAAGAATGGTGGGCCGA GGAACCCAGAGAAGATAGAACGAATGTGTGCCCTTTTTACAGATCTGAGCAGCAAAGATATGAAGAGAGATTTGTATATCGTTGCCCATG TGATCCGAATAGGCCGGATGCTCCTGAACGACTCAAAGAAAGGTCCTCCTCACCTGCACTACAGGCGACCATATGGCTGTGCGGTCCTAA GCATCTTGGATGTCCTACAGTCACTCACAGAAGTAAAGGAAGAAAAGGATTTTGTTCTTAAGGTTTACACGTGCAACAACGAGAGTGAGT GGTCCCAGATCCACGAGAACATCATCCGAAAGTCCAGTGCCAAGTACTCTGCCCCCAGCGCCAGCCATGGTCTTATCATTTCTCTGCAGC TTCTTCGTGGAGACATGGAACAGATTCGGAGAGAAAATCCCATGATATTTAATAGGGGATTGGCAATTACAAGAAAATTGGGATTTCCTG ATGTCATTATGCCAGGTGATATCCGCAATGACCTGTACCTAACCCTGGAGAAGGGGGATTTCGAGAGAGGAGGAAAGAGTGTACAAAAGA ATATTGAAGTGACCATGTATGTGCTTTATGCAGATGGAGAAATCTTGAAGGATTGCATCAGCTTGGGTTCAGGAGAGCCAAATAGGAGTT CCTACCACTCCTTTGTCCTCTACCACAGTAATAGTCCTCGCTGGGGAGAAATTATCAAATTGCCTATCCCCATTGACCGGTTCCGGGGCT CCCACCTGCGCTTTGAGTTCAGACATTGTTCCACAAAGGACAAAGGGGAAAAGAAACTCTTTGGCTTTGCATTCTCAACCCTGATGCGTG ATGATGGCACCACCCTCTCAGATGATATTCACGAGCTTTATGTGTACAAGTGTGATGAGAATAGCACGTTTAATAACCATGCTCTGTACC TGGGCCTGCCCTGCTGCAAAGAGGACTACAATGGCTGCCCTAATATTCCTTCTAGCCTCATCTTCCAGCGCAGCACCAAAGAGTCTTTCT TCATCTCCACTCAGCTCTCCTCTACCAAACTCACCCAGAATGTGGACCTCCTAGCTCTGCTGAAGTGGAAAGCCTTCCCCGACCGGATCA TGGATGTACTAGGGCGGCTGCGGCATGTCAGTGGGGAGGAAATTGTTAAGTTTCTGCAGGACATCTTAGATACACTCTTTGTGATTTTGG ATGATAATACAGAGAAGTACGGCCTGTTGGTTTTTCAGTCTCTGGTGTTCATCATCAACCTGCTCCGAGACATCAAGTATTTTCACTTTC GACCTGTGATGGACACGTATATCCAGAAGCACTTTGCTGGAGCTCTGGCATACAAGGAGCTCATCCGCTGTTTGAAGTGGTATATGGACT GCTCAGCAGAACTGATTCGACAGGACCACATTCAAGAAGCTATGCGGGCCTTGGAGTACCTTTTCAAGTTCATTGTACAGTCACGGATCC TGTACTCACGAGCCACTTGTGGAATGGAAGAGGAACAATTCAGATCCAGTATCCAAGAACTTTTCCAGTCCATCCGGTTTGTGCTCAGTC TGGACAGCCGAAACTCAGAAACACTCCTTTTTACTCAGGCTGCACTCCTCAATTCTTTCCCAACCATCTTTGATGAGCTTCTGCAAATGT TCACCGTGCAAGAGGTGGCAGAGTTTGTGAGAGGGACACTGGGGAGCATGCCCAGCACTGTGCACATTGGGCAGTCAATGGACGTGGTCA AGCTGCAGTCCATTGCCAGGACAGTGGATAGCCGCCTGTTTTCTTTCTCAGAATCCCGCCGCATCCTGCTTCCTGTGGTTCTCCATCACA TTCACCTTCACCTGAGGCAGCAGAAAGAGCTGCTAATTTGCTCAGGGATTCTTGGCAGCATCTTCTCCATCGTCAAGACCAGCTCTCTGG AGGCAGATGTCATGGAGGAAGTAGAGATGATGGTGGAGAGCCTCCTGGACGTGCTCTTGCAGACTCTGCTCACCATCATGAGCAAATCGC ACGCTCAGGAGGCGGTAAGAGGGCAGCGGTGCCCGCAGTGCACAGCCGAGATCACTGGCGAGTATGTGTCCTGCCTTCTCTCACTGCTCC GCCAGATGTGTGACACCCATTTCCAGCACCTCCTGGACAACTTCCAGAGCAAAGATGAACTCAAGGAATTTCTGCTGAAGATTTTTTGCG TGTTCCGGAACCTGATGAAGATGAGTGTCTTCCCTCGGGACTGGATGGTAATGAGACTGCTCACAAGCAATATTATAGTCACTACTGTCC AGTACCTGTCCTCTGCACTGCACAAGAATTTCACAGAGACTGACTTTGACTTTAAGGTGTGGAATTCTTACTTTAGCCTGGCAGTTCTAT TCATAAATCAGCCAAGCCTTCAGCTAGAAATTATCACCTCAGCCAAAAGGAAGAAGATTCTAGATAAGTATGGGGACATGCGTGTAATGA TGGCCTATGAACTGTTCAGCATGTGGCAGAATTTGGGTGAACATAAGATCCACTTTATTCCGGGAATGATTGGTCCTTTTCTGGGTGTGA CACTGGTCCCACAGCCAGAAGTACGGAATATCATGATTCCCATCTTTCATGACATGATGGACTGGGAGCAGAGAAAAAATGGCAACTTCA AACAGGTGGAGGCCGAGTTGATTGACAAGCTGGACAGCATGGTGTCAGAAGGGAAAGGTGACGAGAGCTACAGGGAGCTCTTCAGCCTAC TAACCCAGCTGTTTGGGCCCTACCCCAGCCTGCTGGAGAAGGTTGAACAAGAAACATGGCGCGAGACCGGCATTTCCTTTGTGACCTCAG TCACCCGCCTCATGGAACGTCTTCTTGACTACAGGGACTGCATGAAAGGAGAGGAAACAGAGAATAAGAAGATAGGCTGCACTGTTAACC TGATGAATTTTTACAAATCTGAGATTAACAAGGAAGAAATGTATATCCGCTACATCCATAAGCTTTGTGACATGCACTTGCAGGCCGAAA ACTACACAGAGGCCGCATTTACCCTGCTCCTTTACTGTGAGCTGCTGCAGTGGGAGGACCGGCCACTACGGGAATTCCTCCACTACCCAT CGCAGACAGAGTGGCAGCGGAAGGAGGGACTGTGCCGGAAGATCATTCACTACTTCAACAAAGGCAAGAGCTGGGAGTTTGGGATCCCAC TGTGCAGGGAGCTGGCGTGTCAGTACGAGAGCCTCTATGATTACCAGAGCCTCAGCTGGATTCGGAAAATGGAGGCCAGCTACTATGACA ACATTATGGAGCAGCAACGCCTGGAGCCTGAGTTCTTTCGGGTCGGCTTCTATGGCAGGAAGTTTCCTTTCTTTCTTCGGAACAAAGAAT ACGTGTGCCGTGGCCATGACTACGAGAGGCTGGAGGCCTTCCAGCAGAGGATGCTCAGTGAGTTTCCGCAGGCTGTCGCCATGCAGCACC CCAACCATCCTGATGACGCCATCCTACAGTGCGATGCCCAGTACTTGCAGATCTATGCAGTGACGCCCATTCCAGATTATGTGGATGTTC TGCAGATGGATAGGGTACCAGATCGAGTCAAGAGCTTCTATCGCGTCAACAATGTGAGGAAGTTCCGGTATGACAGGCCTTTTCACAAAG GCCCCAAGGACAAGGAGAATGAATTCAAGAGCCTGTGGATTGAACGTACCACACTGACCCTGACCCACAGCTTGCCTGGCATCTCTCGGT GGTTTGAAGTGGAGAGGAGGGAACTGGTGGAGGTGAGCCCTCTGGAGAATGCCATCCAAGTGGTTGAGAATAAGAACCAGGAGCTACGCT CCCTGATCAGCCAGTATCAACACAAGCAGGTGCATGGCAACATTAACCTGCTAAGCATGTGCCTGAATGGTGTCATTGATGCAGCTGTCA ATGGAGGCATTGCACGCTATCAGGAGGCCTTCTTTGATAAAGATTACATCAACAAGCACCCAGGAGATGCTGAGAAGATCACCCAGCTCA AGGAGCTTATGCAGGAGCAGGTTCATGTCCTTGGAGTTGGGCTAGCAGTTCATGAGAAGTTTGTGCACCCAGAAATGCGGCCTCTGCATA AGAAGCTAATTGATCAGTTCCAGATGATGCGGGCCAGTCTCTACCATGAGTTTCCAGGTTTGGATAAGCTAAGTCCTGCATGTTCAGGCA CCAGCACCCCACGGGGAAATGTTCTGGCATCCCATAGCCCCATGAGTCCGGAGAGCATCAAGATGACCCACCGGCACAGCCCCATGAACT TGATGGGCACAGGCCGCCATTCATCATCCTCTCTCTCCTCACATGCGTCTAGTGAAGCAGGAAACATGGTGATGCTGGGTGACGGCTCCA TGGGTGATGCTCCTGAGGACCTGTACCACCACATGCAGCTCGCGTATCCCAACCCCAGGTACCAAGGCTCAGTCACCAACGTCTCTGTTC TGTCCTCGTCCCAGGCAAGCCCTTCTTCCTCCAGCCTGAGTTCCACTCACTCAGCACCATCCCAGATGATTACCTCTGCCCCTTCCAGTG CCCGAGGCTCTCCCTCTCTGCCAGATAAGTACCGCCATGCCCGTGAAATGATGTTGTTGCTGCCCACATACCGGGACCGCCCAAGCAGTG CCATGTATCCAGCAGCCATCCTGGAGAACGGACAGCCGCCGAATTTCCAGCGAGCCCTGTTCCAGCAAGTGGTCGGAGCCTGCAAACCCT GCAGTGATCCCAATCTGTCTGTGGCTGAAAAAGGTCATTACTCCCTACACTTTGACGCCTTCCACCACCCTCTGGGTGATACCCCCCCAG CCCTCCCTGCCCGGACCCTGCGCAAGTCTCCTCTCCACCCTATCCCAGCCTCCCCCACAAGCCCCCAGTCAGGTCTGGACGGCAGCAACT CTACGCTGTCCGGCAGTGCCAGCAGCGGCGTGTCCTCCTTGAGTGAGAGTAACTTTGGGCACTCCTCGGAGGCCCCACCTCGCACTGACA CCATGGACTCCATGCCAAGTCAGGCCTGGAATGCTGACGAAGATCTTGAGCCACCCTACCTCCCTGTCCACTACAGCCTCTCTGAGTCTG CCGTCCTGGACTCCATCAAGGCCCAGCCATGCCGAAGCCACTCAGCCCCAGGGTGCGTCATCCCTCAGGACCCCATGGACCCGCCTGCGC TGCCGCCCAAGCCCTACCACCCCCGCCTGCCGGCCCTGGAGCACGATGAGGGGGTGCTGCTGCGTGAAGAGACTGAGAGGCCTCGAGGCC TGCACCGCAAGGCTCCATTGCCTCCTGGGAGCGCTAAGGAGGAGCAGGCCCGCATGGCCTGGGAGCACGGCCGAGGGGAGCAGTGAGGGG CAACGAGGCGGCTGGGATGCCGCCCTCAGTAAGCAGCTTGCCAATCACTCCAGGTCTGAAAAGCAAGTCCCCCAGCCCCACCCCAGGGAG CCAGAGAGGCTTGCACTCAGGAGAGAACCACCCCCAAGTCTCCGTTCTACTGCCGTGAACTCATGTGTTGCCATGTACAGAGGCCACAGC AGCATGAAGGGTTGTGGCTTCCCTTTTTATTTTTTTACATTTCCATTTCTATGGGTTTTCCTTTCTTTCCTTTATGCAGTAGATGCTTTC TTCCTCCTGCAGTTCTGGACCATGTGGAGCTACATGGAGAAATTGCACAGACAGAATCACTTTGCCACACTGCAGGGCCCAGGAGTGGGA GCCCAGGCCCTCCCTCCAGGGTAGAGATGCACCGAATGGAAATTGCACTAAGGACCTCTTCCTTTGCTGTATGGACAGAAGAGTTCATGG TTGCATTCAGGGATTGCAAGGACCATATAGACATGTCACAGGTGGAAAAAGGGCCACAAGCCGTTTTGCACAAATGCCTGCCCACCTGCC CCTCTTCCATCCAGGAGTGTGCTACTGAGGGGCTGGCTGGACCAACCTGCTGGCTCAGGCATGTGACTGGCCTAACTGCATGCCCAGGGC ACTGCCAGGGTTCAATGGGCCAGCCGTCTCCTACTCCACCTTGGATTTTTCTCTCCATCACATCATTTCTGACCATTTGCTCCCTTCCAT TCTTGAAACACCTCATGCCCCACAGGAGCCCCAGTGGTGACTGGATCTGCAAGGGTTATCTCCCGCCCTCTGGGGTTTGAGTGGAGGTAT GGAGCCAGAGAGGCTATCCTAGCTACCTTCCTCCTAGGGGGAGCTGGTCCCCTTCCTATGTGGTAGAGAGACTGGTGTAAGAGTGTGGGG TGTGGCAGGCGCCGGAAATCCTCAAAGCTTTCAGAAGCATCCAGAATGCCTACCATCAGCTCCTGAATCAGGGATTTTCAGCACTACCTC TGAGCCATGGGGTTGGCTGCCCAGCCAGGCTTCCAGGCCCTGAGGACATGTGGTCAGGTTCAGCAGGCTCCTGGGTAAAGAGGGTGGGAG GGGGCTTCTCCTTTTGGAAGCAGATAGCCATGCAGGTAGAATTGTCATCTCCCAAGTGGCCACATACAGCAACCCACTCCAGGCCATGGG GACCACCACTCAGGGTTCGGGGCTGGCAGGAGGGTAGTTTCTCCAGTCTCCCCAGTCTGTTGGTGTCTTTATAGGAAACTATAAAGCAGA GCAGTGGTGTCTTTAGAGGAAACTCATTCAAGTCAGGGCACTGATTTTCCTCTCAGTTTATTATTTGGGGGGATAGGGTCAGGTGGGTAT AGTAGTACTTTACCAGGGTGCTTTTAAGTTACTTTAAAAAAAGCCTACAAAATATTTTTTTTCTTTTATTTGCTCGAGTTCACATTAATG ATGGTCACAAGGCTGCCTTGTTGGGCAGGCGTATTGCCCCCAGTTCCTCTTCTGCTGGCCTGTATGACCTCCACAGCCAGGCCCTGGGCC CAAGCCCCTTGTCCCTTCTCCACTGCCCCTCTTTCCAGACAGTAAAGGCCATGGTCAGTGTGTTTTTCTCTTGTAAACAAACCCCAGCTT GTTTAACAGAAATGCTAATAACCTACTGGGAAAGATGGAGGTCTAAATTACCTCCAGGGTTTTTCTGGGGGTTTATCACCAGTGTGGGTC CCTTCTGATACCACCAGGTTCACTCCAGGCAGAGTGGGGCGGAAGGCTGCTGAGGATATGGGTCAGTTACAGCAGCCCTCACCTCAAAGG GCTGGCCTGCTTCTCAGCCTACATTCATTTGCAAGCTTCAATCTCTGGACCATCTGGTGTTCACAGGTGTTAGAGGGTTAGGGGTTAGGG GCTAGTTTTGGATTTGATTCATAGGTAGGAGGGCTTAGATTTTAAGGCACTTCTGAAAGTCAATCCCTGGACAAGGCAGTCATCACATAA GAACAGCTACCTTCTCCACTTGGTGGCACAAGAGGTAGGGAGGGGAGTATGGGTTCATTTGGCTTCGCATTATGCAAGGTGAAACCGTTT GTTTTCCCTCTCCATTTTCCCTAACTAAATGAAAAGGACACATTCTGAAATCCCTTTTGTTGGAGAATAAGTCAGTCTGAGGGGAAATGG GAGGCCAGAGATGAGAACCCTTTGAAAAGATTGTAAAATACTGATTTTCATTCTTTCAAGCTTATTTGTAAATACCTATTTGAATGCTGT GTATTTGTACAGGAATTTGAGCAAAAAATGTATAGAGTGTGATGTCCAATTGGTATTCAGCACTATAAATGTGTTTTTAACCTCCCGCAT TCTGTGCTTATTTAAAACAAGGAAACTTCTAACCATTTCTTTTGTGTATTCATGTTTAAAGAAAAAAAGTGATTTAAAAATGATCTTACC TGTACCAGAAAAGCAAAGTTAAAGGAAACAAAATTTGTACCATTGTCCCAAGAGGTATTTTACTGTATATATTGTGGTAGCATGTTCAAA ATCCAACAAGTAATGTGAATTTTAGATGTAAATATCTGCCACTTGATTTTTTTTCCCCCTTTCCCCACTTCCTTGACTGCTGTGATGTGA >51615_51615_2_MAPKAPK3-DOCK3_MAPKAPK3_chr3_50655215_ENST00000446044_DOCK3_chr3_50927457_ENST00000266037_length(amino acids)=2049AA_BP=0 MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKGIFPANYIHLKKAIVSN RGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDL VPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTMRPRHGETCRMPVPHHFFLSLKSFTYNTIGEDTDVFFSLYDMREGKQISER FLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPPHLHYRRPYGCAVLSILDVLQSLTEVKEEKDFV LKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKG DFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKK LFGFAFSTLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLA LLKWKAFPDRIMDVLGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYK ELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNS FPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILG SIFSIVKTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAVRGQRCPQCTAEITGEYVSCLLSLLRQMCDTHFQHLLDNFQSKD ELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSAKRKK ILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSMVSEGK GDESYRELFSLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYI HKLCDMHLQAENYTEAAFTLLLYCELLQWEDRPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYESLYDYQSLS WIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIY AVTPIPDYVDVLQMDRVPDRVKSFYRVNNVRKFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAI QVVENKNQELRSLISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYINKHPGDAEKITQLKELMQEQVHVLGVGLAVHE KFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPESIKMTHRHSPMNLMGTGRHSSSSLSSHASSE AGNMVMLGDGSMGDAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKYRHAREMML LLPTYRDRPSSAMYPAAILENGQPPNFQRALFQQVVGACKPCSDPNLSVAEKGHYSLHFDAFHHPLGDTPPALPARTLRKSPLHPIPASP TSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEAPPRTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPCRSHSAPGC -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MAPKAPK3-DOCK3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MAPKAPK3-DOCK3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MAPKAPK3-DOCK3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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