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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MAPKAPK5-GNPTAB (FusionGDB2 ID:51624) |
Fusion Gene Summary for MAPKAPK5-GNPTAB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPKAPK5-GNPTAB | Fusion gene ID: 51624 | Hgene | Tgene | Gene symbol | MAPKAPK5 | GNPTAB | Gene ID | 8550 | 79158 |
| Gene name | MAPK activated protein kinase 5 | N-acetylglucosamine-1-phosphate transferase subunits alpha and beta | |
| Synonyms | MAPKAP-K5|MK-5|MK5|PRAK | GNPTA|ICD | |
| Cytomap | 12q24.12-q24.13 | 12q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MAP kinase-activated protein kinase 5MAPKAP kinase 5MAPKAPK-5mitogen-activated protein kinase-activated protein kinase 5p38-regulated/activated protein kinase | N-acetylglucosamine-1-phosphotransferase subunits alpha/betaGlcNAc phosphotransferaseN-acetylglucosamine-1-phosphate transferase alpha and beta subunitsUDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/betaUDP-N-acetylglucosamine-lysosomal-e | |
| Modification date | 20200313 | 20200328 | |
| UniProtAcc | Q8IW41 | Q3T906 | |
| Ensembl transtripts involved in fusion gene | ENST00000546394, ENST00000550735, ENST00000551404, ENST00000547305, | ENST00000299314, ENST00000549940, ENST00000392919, ENST00000549165, | |
| Fusion gene scores | * DoF score | 13 X 12 X 10=1560 | 7 X 8 X 5=280 |
| # samples | 20 | 8 | |
| ** MAII score | log2(20/1560*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAPKAPK5 [Title/Abstract] AND GNPTAB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MAPKAPK5(112304035)-GNPTAB(102183835), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | MAPKAPK5-GNPTAB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MAPKAPK5-GNPTAB seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MAPKAPK5-GNPTAB seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAPKAPK5 | GO:0006417 | regulation of translation | 21329882 |
| Hgene | MAPKAPK5 | GO:0007265 | Ras protein signal transduction | 17254968 |
| Hgene | MAPKAPK5 | GO:0046777 | protein autophosphorylation | 21329882 |
| Hgene | MAPKAPK5 | GO:0090400 | stress-induced premature senescence | 17254968 |
| Tgene | GNPTAB | GO:0046835 | carbohydrate phosphorylation | 19955174|23733939 |
| Fusion gene breakpoints across MAPKAPK5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across GNPTAB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-BH-A18H-01A | MAPKAPK5 | chr12 | 112304035 | - | GNPTAB | chr12 | 102183835 | - |
| ChimerDB4 | BRCA | TCGA-BH-A18H-01A | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
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Fusion Gene ORF analysis for MAPKAPK5-GNPTAB |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000546394 | ENST00000299314 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| 3UTR-3CDS | ENST00000546394 | ENST00000549940 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| 3UTR-intron | ENST00000546394 | ENST00000392919 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| 3UTR-intron | ENST00000546394 | ENST00000549165 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| 5CDS-intron | ENST00000550735 | ENST00000392919 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| 5CDS-intron | ENST00000550735 | ENST00000549165 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| 5CDS-intron | ENST00000551404 | ENST00000392919 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| 5CDS-intron | ENST00000551404 | ENST00000549165 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| Frame-shift | ENST00000550735 | ENST00000299314 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| Frame-shift | ENST00000550735 | ENST00000549940 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| Frame-shift | ENST00000551404 | ENST00000299314 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| Frame-shift | ENST00000551404 | ENST00000549940 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| intron-3CDS | ENST00000547305 | ENST00000299314 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| intron-3CDS | ENST00000547305 | ENST00000549940 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| intron-intron | ENST00000547305 | ENST00000392919 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| intron-intron | ENST00000547305 | ENST00000549165 | MAPKAPK5 | chr12 | 112304035 | + | GNPTAB | chr12 | 102183835 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for MAPKAPK5-GNPTAB |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MAPKAPK5-GNPTAB |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:112304035/:102183835) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPKAPK5 | GNPTAB |
| FUNCTION: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. | FUNCTION: Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. {ECO:0000269|PubMed:19955174, ECO:0000269|PubMed:23733939, ECO:0000269|PubMed:28918368}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MAPKAPK5-GNPTAB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for MAPKAPK5-GNPTAB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MAPKAPK5-GNPTAB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MAPKAPK5-GNPTAB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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