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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MARCH10-SUN1 (FusionGDB2 ID:51674)

Fusion Gene Summary for MARCH10-SUN1

check button Fusion gene summary
Fusion gene informationFusion gene name: MARCH10-SUN1
Fusion gene ID: 51674
HgeneTgene
Gene symbol

MARCH10

SUN1

Gene ID

162333

23353

Gene namemembrane associated ring-CH-type finger 10Sad1 and UNC84 domain containing 1
SynonymsMARCH-X|MARCH10|RNF190UNC84A
Cytomap

17q23.2

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase MARCH10RING-type E3 ubiquitin transferase MARCH10membrane associated ring finger 10membrane-associated RING finger protein 10membrane-associated RING-CH protein Xmembrane-associated ring finger (C3HC4) 10, E3 ubiqSUN domain-containing protein 1Sad1 unc-84 domain protein 1protein unc-84 homolog Asad1/unc-84 protein-like 1unc-84 homolog A
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000311269, ENST00000456609, 
ENST00000544856, ENST00000582358, 
ENST00000583600, 		ENST00000389574, 
ENST00000401592, ENST00000403868, 
ENST00000405266, ENST00000413514, 
ENST00000425407, ENST00000452783, 
ENST00000456758, ENST00000457378, 
ENST00000469755, 
Fusion gene scores* DoF score1 X 1 X 1=113 X 11 X 5=715
# samples 116
** MAII scorelog2(1/1*10)=3.32192809488736log2(16/715*10)=-2.15987133677839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MARCH10 [Title/Abstract] AND SUN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMARCH10(60807166)-SUN1(855116), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSUN1

GO:0090286

cytoskeletal anchoring at nuclear membrane

18396275

TgeneSUN1

GO:0090292

nuclear matrix anchoring at nuclear membrane

18396275


check buttonFusion gene breakpoints across MARCH10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SUN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAY653515MARCH10chr17

60807166

-SUN1chr7

855116

+


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Fusion Gene ORF analysis for MARCH10-SUN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000311269ENST00000389574MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000311269ENST00000401592MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000311269ENST00000403868MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000311269ENST00000405266MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000311269ENST00000413514MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000311269ENST00000425407MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000311269ENST00000452783MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000311269ENST00000456758MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000311269ENST00000457378MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000311269ENST00000469755MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000456609ENST00000389574MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000456609ENST00000401592MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000456609ENST00000403868MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000456609ENST00000405266MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000456609ENST00000413514MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000456609ENST00000425407MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000456609ENST00000452783MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000456609ENST00000456758MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000456609ENST00000457378MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000456609ENST00000469755MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000544856ENST00000389574MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000544856ENST00000401592MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000544856ENST00000403868MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000544856ENST00000405266MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000544856ENST00000413514MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000544856ENST00000425407MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000544856ENST00000452783MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000544856ENST00000456758MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000544856ENST00000457378MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000544856ENST00000469755MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000582358ENST00000389574MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000582358ENST00000401592MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000582358ENST00000403868MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000582358ENST00000405266MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000582358ENST00000413514MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000582358ENST00000425407MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000582358ENST00000452783MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000582358ENST00000456758MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000582358ENST00000457378MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000582358ENST00000469755MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000583600ENST00000389574MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000583600ENST00000401592MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000583600ENST00000403868MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000583600ENST00000405266MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000583600ENST00000413514MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000583600ENST00000425407MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000583600ENST00000452783MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000583600ENST00000456758MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000583600ENST00000457378MARCH10chr17

60807166

-SUN1chr7

855116

+
intron-intronENST00000583600ENST00000469755MARCH10chr17

60807166

-SUN1chr7

855116

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MARCH10-SUN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MARCH10-SUN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:60807166/:855116)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MARCH10-SUN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MARCH10-SUN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MARCH10-SUN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MARCH10-SUN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource