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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MARCH6-HSPA9 (FusionGDB2 ID:51698)

Fusion Gene Summary for MARCH6-HSPA9

check button Fusion gene summary
Fusion gene informationFusion gene name: MARCH6-HSPA9
Fusion gene ID: 51698
HgeneTgene
Gene symbol

MARCH6

HSPA9

Gene ID

10299

3313

Gene namemembrane associated ring-CH-type finger 6heat shock protein family A (Hsp70) member 9
SynonymsDOA10|FAME3|MARCH-VI|MARCH6|RNF176|TEB4CRP40|CSA|EVPLS|GRP-75|GRP75|HEL-S-124m|HSPA9B|MOT|MOT2|MTHSP75|PBP74|SAAN|SIDBA4
Cytomap

5p15.2

5q31.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MARCH6RING finger protein 176RING-type E3 ubiquitin transferase MARCH6doa10 homologmembrane associated ring finger 6membrane-associated RING finger protein 6membrane-associated RING-CH finger protein 6membrane-associatedstress-70 protein, mitochondrial75 kDa glucose-regulated proteincatecholamine-regulated protein 40epididymis secretory sperm binding protein Li 124mheat shock 70kD protein 9Bheat shock 70kDa protein 9 (mortalin)mortalin, perinuclearmortalin-2morta
Modification date2020031320200327
UniProtAcc.

P38646

Ensembl transtripts involved in fusion geneENST00000274140, ENST00000449913, 
ENST00000503788, ENST00000510792, 
ENST00000606497, 		ENST00000501917, 
ENST00000297185, 
Fusion gene scores* DoF score14 X 8 X 8=89610 X 9 X 4=360
# samples 1410
** MAII scorelog2(14/896*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MARCH6 [Title/Abstract] AND HSPA9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMARCH6(10378944)-HSPA9(137903411), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMARCH6

GO:0010498

proteasomal protein catabolic process

15673284

HgeneMARCH6

GO:0016567

protein ubiquitination

24449766

HgeneMARCH6

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

24449766

HgeneMARCH6

GO:0070936

protein K48-linked ubiquitination

15673284


check buttonFusion gene breakpoints across MARCH6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HSPA9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA922289MARCH6chr5

10378944

+HSPA9chr5

137903411

-


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Fusion Gene ORF analysis for MARCH6-HSPA9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000274140ENST00000501917MARCH6chr5

10378944

+HSPA9chr5

137903411

-
5CDS-intronENST00000449913ENST00000501917MARCH6chr5

10378944

+HSPA9chr5

137903411

-
In-frameENST00000274140ENST00000297185MARCH6chr5

10378944

+HSPA9chr5

137903411

-
In-frameENST00000449913ENST00000297185MARCH6chr5

10378944

+HSPA9chr5

137903411

-
intron-3CDSENST00000503788ENST00000297185MARCH6chr5

10378944

+HSPA9chr5

137903411

-
intron-3CDSENST00000510792ENST00000297185MARCH6chr5

10378944

+HSPA9chr5

137903411

-
intron-3CDSENST00000606497ENST00000297185MARCH6chr5

10378944

+HSPA9chr5

137903411

-
intron-intronENST00000503788ENST00000501917MARCH6chr5

10378944

+HSPA9chr5

137903411

-
intron-intronENST00000510792ENST00000501917MARCH6chr5

10378944

+HSPA9chr5

137903411

-
intron-intronENST00000606497ENST00000501917MARCH6chr5

10378944

+HSPA9chr5

137903411

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000449913MARCH6chr510378944+ENST00000297185HSPA9chr5137903411-30463861001890596
ENST00000274140MARCH6chr510378944+ENST00000297185HSPA9chr5137903411-2982322361826596

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000449913ENST00000297185MARCH6chr510378944+HSPA9chr5137903411-0.0007101840.99928975
ENST00000274140ENST00000297185MARCH6chr510378944+HSPA9chr5137903411-0.0007256560.9992743

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Fusion Genomic Features for MARCH6-HSPA9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MARCH6-HSPA9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:10378944/chr5:137903411)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HSPA9

P38646

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in the control of cell proliferation and cellular aging (By similarity). {ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:26702583}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+3261_6263911.0Zinc fingerRING-CH-type
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+3251_6263863.0Zinc fingerRING-CH-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326113_14263911.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326164_28363911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+3261_9163911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326305_33663911.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326358_37663911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326398_42163911.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326443_48063911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326502_51963911.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326541_63263911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326654_67863911.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326700_72163911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326743_76463911.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326786_81563911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326837_84863911.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326870_91063911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325113_14263863.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325164_28363863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+3251_9163863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325305_33663863.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325358_37663863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325398_42163863.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325443_48063863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325502_51963863.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325541_63263863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325654_67863863.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325700_72163863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325743_76463863.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325786_81563863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325837_84863863.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325870_91063863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123113_1420806.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123164_2830806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+1231_910806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123305_3360806.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123358_3760806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123398_4210806.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123443_4800806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123502_5190806.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123541_6320806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123654_6780806.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123700_7210806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123743_7640806.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123786_8150806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123837_8480806.0Topological domainExtracellular
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123870_9100806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326143_16363911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326284_30463911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326337_35763911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326377_39763911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326422_44263911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326481_50163911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326520_54063911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326633_65363911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326679_69963911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326722_74263911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326765_78563911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326816_83663911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+326849_86963911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000274140+32692_11263911.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325143_16363863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325284_30463863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325337_35763863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325377_39763863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325422_44263863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325481_50163863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325520_54063863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325633_65363863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325679_69963863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325722_74263863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325765_78563863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325816_83663863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+325849_86963863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000449913+32592_11263863.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123143_1630806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123284_3040806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123337_3570806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123377_3970806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123422_4420806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123481_5010806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123520_5400806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123633_6530806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123679_6990806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123722_7420806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123765_7850806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123816_8360806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+123849_8690806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+12392_1120806.0TransmembraneHelical
HgeneMARCH6chr5:10378944chr5:137903411ENST00000503788+1231_620806.0Zinc fingerRING-CH-type


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Fusion Gene Sequence for MARCH6-HSPA9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51698_51698_1_MARCH6-HSPA9_MARCH6_chr5_10378944_ENST00000274140_HSPA9_chr5_137903411_ENST00000297185_length(transcript)=2982nt_BP=322nt
CCTCTCGCTTCCTCTCTCGCACCTGAGCGTACGCACCTGCCCGGGCCCGGCTCCCTCCTCCTCTCCCCTCCCTCTTTCCCCGCCCGGCCG
CGGGAGCCTCGTGGCTGCGTCACCGCCGCCCCCCCAGACAAGATGGACACCGCGGAGGAAGACATATGTAGAGTGTGTCGGTCAGAAGGA
ACACCTGAGAAACCGCTTTATCATCCTTGTGTATGTACTGGCAGTATTAAGTTTATCCATCAAGAATGCTTAGTTCAATGGCTGAAACAC
AGTCGAAAAGAATACTGTGAATTATGCAAGCACAGATTTGCTTTTACACCAAAAAATTACTTGGGGCACACAGCAAAAAATGCTGTGATC
ACAGTCCCAGCTTATTTCAATGACTCGCAGAGACAGGCCACTAAAGATGCTGGCCAGATATCTGGACTGAATGTGCTTCGGGTGATTAAT
GAGCCCACAGCTGCTGCTCTTGCCTATGGTCTAGACAAATCAGAAGACAAAGTCATTGCTGTATATGATTTAGGTGGTGGAACTTTTGAT
ATTTCTATCCTGGAAATTCAGAAAGGAGTATTTGAGGTGAAATCCACAAATGGGGATACCTTCTTAGGTGGGGAAGACTTTGACCAGGCC
TTGCTACGGCACATTGTGAAGGAGTTCAAGAGAGAGACAGGGGTTGATTTGACTAAAGACAACATGGCACTTCAGAGGGTACGGGAAGCT
GCTGAAAAGGCTAAATGTGAACTCTCCTCATCTGTGCAGACTGACATCAATTTGCCCTATCTTACAATGGATTCTTCTGGACCCAAGCAT
TTGAATATGAAGTTGACCCGTGCTCAATTTGAAGGGATTGTCACTGATCTAATCAGAAGGACTATCGCTCCATGCCAAAAAGCTATGCAA
GATGCAGAAGTCAGCAAGAGTGACATAGGAGAAGTGATTCTTGTGGGTGGCATGACTAGGATGCCCAAGGTTCAGCAGACTGTACAGGAT
CTTTTTGGCAGAGCCCCAAGTAAAGCTGTCAATCCTGATGAGGCTGTGGCCATTGGAGCTGCCATTCAGGGAGGTGTGTTGGCCGGCGAT
GTCACGGATGTGCTGCTCCTTGATGTCACTCCCCTGTCTCTGGGTATTGAAACTCTAGGAGGTGTCTTTACCAAACTTATTAATAGGAAT
ACCACTATTCCAACCAAGAAGAGCCAGGTATTCTCTACTGCCGCTGATGGTCAAACGCAAGTGGAAATTAAAGTGTGTCAGGGTGAAAGA
GAGATGGCTGGAGACAACAAACTCCTTGGACAGTTTACTTTGATTGGAATTCCACCAGCCCCTCGTGGAGTTCCTCAGATTGAAGTTACA
TTTGACATTGATGCCAATGGGATAGTACATGTTTCTGCTAAAGATAAAGGCACAGGACGTGAGCAGCAGATTGTAATCCAGTCTTCTGGT
GGATTAAGCAAAGATGATATTGAAAATATGGTTAAAAATGCAGAGAAATATGCTGAAGAAGACCGGCGAAAGAAGGAACGAGTTGAAGCA
GTTAATATGGCTGAAGGAATCATTCACGACACAGAAACCAAGATGGAAGAATTCAAGGACCAATTACCTGCTGATGAGTGCAACAAGCTG
AAAGAAGAGATTTCCAAAATGAGGGAGCTCCTGGCTAGAAAAGACAGCGAAACAGGAGAAAATATTAGACAGGCAGCATCCTCTCTTCAG
CAGGCATCACTGAAGCTGTTCGAAATGGCATACAAAAAGATGGCATCTGAGCGAGAAGGCTCTGGAAGTTCTGGCACTGGGGAACAAAAG
GAAGATCAAAAGGAGGAAAAACAGTAATAATAGCAGAAATTTTGAAGCCAGAAGGACAACATATGAAGCTTAGGAGTGAAGAGACTTCCT
GAGCAGAAATGGGCGAACTTCAGTCTTTTTACTGTGTTTTTGCAGTATTCTATATATAATTTCCTTAATTTGTAAATTTAGTGACCATTA
GCTAGTGATCATTTAATGGACAGTGATTCTAACAGTATAAAGTTCACAATATTCTATGTCCCTAGCCTGTCATTTTTCAGCTGCATGTAA
AAGGAGGTAGGATGAATTGATCATTATAAAGATTTAACTATTTTATGCTGAAGTGACCATATTTTCAAGGGGTGAAACCATCTCGCACAC
AGCAATGAAGGTAGTCATCCATAGACTTGAAATGAGACCACATATGGGGATGAGATCCTTCTAGTTAGCCTAGTACTGCTGTACTGGCCT
GTATGTACATGGGGTCCTTCAACTGAGGCCTTGCAAGTCAAGCTGGCTGTGCCATGTTTGTAGATGGGGCAGAGGAATCTAGAACAATGG
GAAACTTAGCTATTTATATTAGGTACAGCTATTAAAACAAGGTAGGAATGAGGCTAGACCTTTAACTTCCCTAAGGCATACTTTTCTAGC
TACCTTCTGCCCTGTGTCTGGCACCTACATCCTTGATGATTGTTCTCTTACCCATTCTGGAATTTTTTTTTTTTTAAATAAATACAGAAA
GCATCTTGATCTCTTGTTTGTGAGGGGTGATGCCCTGAGATTTAGCTTCAAGAATATGCCATGGCTCATGCTTCCCATATTTCCCAAAGA
GGGAAATACAGGATTTGCTAACACTGGTTAAAAATGCAAATTCAAGATTTGGAAGGGCTGTTATAATGAAATAATGAGCAGTATCAGCAT
GTGCAAATCTTGTTTGAAGGATTTTATTTTCTCCCCTTAGACCTTTGGTACATTTAGAATCTTGAAAGTTTCTAGATCTCTAACATGAAA
GTTTCTAGATCTCTAACATGAAAGTTTTTAGATCTCTAACATGAAAACCAAGGTGGCTATTTTCAGGTTGCTTTCAGCTCCAAGTAGAAA
TAACCAGAATTGGCTTACATTAAAGAAACTGCATCTAGAAATAAGTCCTAAGATACTATTTCTATGGCTCAAAAATAAAAGGAACCCAGA

>51698_51698_1_MARCH6-HSPA9_MARCH6_chr5_10378944_ENST00000274140_HSPA9_chr5_137903411_ENST00000297185_length(amino acids)=596AA_BP=94
MPGPGSLLLSPPSFPARPREPRGCVTAAPPDKMDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHR
FAFTPKNYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFE
VKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEG
IVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPL
SLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVS
AKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLA

--------------------------------------------------------------
>51698_51698_2_MARCH6-HSPA9_MARCH6_chr5_10378944_ENST00000449913_HSPA9_chr5_137903411_ENST00000297185_length(transcript)=3046nt_BP=386nt
CCCTCCCCCTCCCGTGTCGCTCGCTTTCTGTCAGCCTCTCTCCCTCTCCCTCTCCCCTCTCCTTCCTCTCGCTTCCTCTCTCGCACCTGA
GCGTACGCACCTGCCCGGGCCCGGCTCCCTCCTCCTCTCCCCTCCCTCTTTCCCCGCCCGGCCGCGGGAGCCTCGTGGCTGCGTCACCGC
CGCCCCCCCAGACAAGATGGACACCGCGGAGGAAGACATATGTAGAGTGTGTCGGTCAGAAGGAACACCTGAGAAACCGCTTTATCATCC
TTGTGTATGTACTGGCAGTATTAAGTTTATCCATCAAGAATGCTTAGTTCAATGGCTGAAACACAGTCGAAAAGAATACTGTGAATTATG
CAAGCACAGATTTGCTTTTACACCAAAAAATTACTTGGGGCACACAGCAAAAAATGCTGTGATCACAGTCCCAGCTTATTTCAATGACTC
GCAGAGACAGGCCACTAAAGATGCTGGCCAGATATCTGGACTGAATGTGCTTCGGGTGATTAATGAGCCCACAGCTGCTGCTCTTGCCTA
TGGTCTAGACAAATCAGAAGACAAAGTCATTGCTGTATATGATTTAGGTGGTGGAACTTTTGATATTTCTATCCTGGAAATTCAGAAAGG
AGTATTTGAGGTGAAATCCACAAATGGGGATACCTTCTTAGGTGGGGAAGACTTTGACCAGGCCTTGCTACGGCACATTGTGAAGGAGTT
CAAGAGAGAGACAGGGGTTGATTTGACTAAAGACAACATGGCACTTCAGAGGGTACGGGAAGCTGCTGAAAAGGCTAAATGTGAACTCTC
CTCATCTGTGCAGACTGACATCAATTTGCCCTATCTTACAATGGATTCTTCTGGACCCAAGCATTTGAATATGAAGTTGACCCGTGCTCA
ATTTGAAGGGATTGTCACTGATCTAATCAGAAGGACTATCGCTCCATGCCAAAAAGCTATGCAAGATGCAGAAGTCAGCAAGAGTGACAT
AGGAGAAGTGATTCTTGTGGGTGGCATGACTAGGATGCCCAAGGTTCAGCAGACTGTACAGGATCTTTTTGGCAGAGCCCCAAGTAAAGC
TGTCAATCCTGATGAGGCTGTGGCCATTGGAGCTGCCATTCAGGGAGGTGTGTTGGCCGGCGATGTCACGGATGTGCTGCTCCTTGATGT
CACTCCCCTGTCTCTGGGTATTGAAACTCTAGGAGGTGTCTTTACCAAACTTATTAATAGGAATACCACTATTCCAACCAAGAAGAGCCA
GGTATTCTCTACTGCCGCTGATGGTCAAACGCAAGTGGAAATTAAAGTGTGTCAGGGTGAAAGAGAGATGGCTGGAGACAACAAACTCCT
TGGACAGTTTACTTTGATTGGAATTCCACCAGCCCCTCGTGGAGTTCCTCAGATTGAAGTTACATTTGACATTGATGCCAATGGGATAGT
ACATGTTTCTGCTAAAGATAAAGGCACAGGACGTGAGCAGCAGATTGTAATCCAGTCTTCTGGTGGATTAAGCAAAGATGATATTGAAAA
TATGGTTAAAAATGCAGAGAAATATGCTGAAGAAGACCGGCGAAAGAAGGAACGAGTTGAAGCAGTTAATATGGCTGAAGGAATCATTCA
CGACACAGAAACCAAGATGGAAGAATTCAAGGACCAATTACCTGCTGATGAGTGCAACAAGCTGAAAGAAGAGATTTCCAAAATGAGGGA
GCTCCTGGCTAGAAAAGACAGCGAAACAGGAGAAAATATTAGACAGGCAGCATCCTCTCTTCAGCAGGCATCACTGAAGCTGTTCGAAAT
GGCATACAAAAAGATGGCATCTGAGCGAGAAGGCTCTGGAAGTTCTGGCACTGGGGAACAAAAGGAAGATCAAAAGGAGGAAAAACAGTA
ATAATAGCAGAAATTTTGAAGCCAGAAGGACAACATATGAAGCTTAGGAGTGAAGAGACTTCCTGAGCAGAAATGGGCGAACTTCAGTCT
TTTTACTGTGTTTTTGCAGTATTCTATATATAATTTCCTTAATTTGTAAATTTAGTGACCATTAGCTAGTGATCATTTAATGGACAGTGA
TTCTAACAGTATAAAGTTCACAATATTCTATGTCCCTAGCCTGTCATTTTTCAGCTGCATGTAAAAGGAGGTAGGATGAATTGATCATTA
TAAAGATTTAACTATTTTATGCTGAAGTGACCATATTTTCAAGGGGTGAAACCATCTCGCACACAGCAATGAAGGTAGTCATCCATAGAC
TTGAAATGAGACCACATATGGGGATGAGATCCTTCTAGTTAGCCTAGTACTGCTGTACTGGCCTGTATGTACATGGGGTCCTTCAACTGA
GGCCTTGCAAGTCAAGCTGGCTGTGCCATGTTTGTAGATGGGGCAGAGGAATCTAGAACAATGGGAAACTTAGCTATTTATATTAGGTAC
AGCTATTAAAACAAGGTAGGAATGAGGCTAGACCTTTAACTTCCCTAAGGCATACTTTTCTAGCTACCTTCTGCCCTGTGTCTGGCACCT
ACATCCTTGATGATTGTTCTCTTACCCATTCTGGAATTTTTTTTTTTTTAAATAAATACAGAAAGCATCTTGATCTCTTGTTTGTGAGGG
GTGATGCCCTGAGATTTAGCTTCAAGAATATGCCATGGCTCATGCTTCCCATATTTCCCAAAGAGGGAAATACAGGATTTGCTAACACTG
GTTAAAAATGCAAATTCAAGATTTGGAAGGGCTGTTATAATGAAATAATGAGCAGTATCAGCATGTGCAAATCTTGTTTGAAGGATTTTA
TTTTCTCCCCTTAGACCTTTGGTACATTTAGAATCTTGAAAGTTTCTAGATCTCTAACATGAAAGTTTCTAGATCTCTAACATGAAAGTT
TTTAGATCTCTAACATGAAAACCAAGGTGGCTATTTTCAGGTTGCTTTCAGCTCCAAGTAGAAATAACCAGAATTGGCTTACATTAAAGA

>51698_51698_2_MARCH6-HSPA9_MARCH6_chr5_10378944_ENST00000449913_HSPA9_chr5_137903411_ENST00000297185_length(amino acids)=596AA_BP=94
MPGPGSLLLSPPSFPARPREPRGCVTAAPPDKMDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHR
FAFTPKNYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFE
VKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEG
IVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPL
SLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVS
AKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MARCH6-HSPA9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneHSPA9chr5:10378944chr5:137903411ENST00000297185417432_679178.33333333333334680.0FXN and ISCU


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneHSPA9chr5:10378944chr5:137903411ENST000002971854171_432178.33333333333334680.0NFS1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MARCH6-HSPA9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MARCH6-HSPA9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource