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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MARCH6-KLF13 (FusionGDB2 ID:51700)

Fusion Gene Summary for MARCH6-KLF13

check button Fusion gene summary
Fusion gene informationFusion gene name: MARCH6-KLF13
Fusion gene ID: 51700
HgeneTgene
Gene symbol

MARCH6

KLF13

Gene ID

10299

51621

Gene namemembrane associated ring-CH-type finger 6Kruppel like factor 13
SynonymsDOA10|FAME3|MARCH-VI|MARCH6|RNF176|TEB4BTEB3|FKLF2|NSLP1|RFLAT-1|RFLAT1
Cytomap

5p15.2

15q13.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MARCH6RING finger protein 176RING-type E3 ubiquitin transferase MARCH6doa10 homologmembrane associated ring finger 6membrane-associated RING finger protein 6membrane-associated RING-CH finger protein 6membrane-associatedKrueppel-like factor 13BTE-binding protein 3RANTES factor of late activated T lymphocytes-1basic transcription element binding protein 3novel Sp1-like zinc finger transcription factor 1transcription factor BTEB3transcription factor NSLP1
Modification date2020031320200313
UniProtAcc.

Q9Y2Y9

Ensembl transtripts involved in fusion geneENST00000274140, ENST00000449913, 
ENST00000503788, ENST00000510792, 
ENST00000606497, 		ENST00000500533, 
ENST00000560473, ENST00000307145, 
Fusion gene scores* DoF score14 X 8 X 8=8965 X 5 X 4=100
# samples 146
** MAII scorelog2(14/896*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MARCH6 [Title/Abstract] AND KLF13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMARCH6(10354029)-KLF13(31664213), # samples:1
Anticipated loss of major functional domain due to fusion event.MARCH6-KLF13 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
MARCH6-KLF13 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMARCH6

GO:0010498

proteasomal protein catabolic process

15673284

HgeneMARCH6

GO:0016567

protein ubiquitination

24449766

HgeneMARCH6

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

24449766

HgeneMARCH6

GO:0070936

protein K48-linked ubiquitination

15673284


check buttonFusion gene breakpoints across MARCH6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KLF13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5720-11AMARCH6chr5

10354029

+KLF13chr15

31664213

+


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Fusion Gene ORF analysis for MARCH6-KLF13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000274140ENST00000500533MARCH6chr5

10354029

+KLF13chr15

31664213

+
5CDS-intronENST00000449913ENST00000500533MARCH6chr5

10354029

+KLF13chr15

31664213

+
5CDS-intronENST00000503788ENST00000500533MARCH6chr5

10354029

+KLF13chr15

31664213

+
Frame-shiftENST00000274140ENST00000560473MARCH6chr5

10354029

+KLF13chr15

31664213

+
Frame-shiftENST00000449913ENST00000560473MARCH6chr5

10354029

+KLF13chr15

31664213

+
Frame-shiftENST00000503788ENST00000560473MARCH6chr5

10354029

+KLF13chr15

31664213

+
In-frameENST00000274140ENST00000307145MARCH6chr5

10354029

+KLF13chr15

31664213

+
In-frameENST00000449913ENST00000307145MARCH6chr5

10354029

+KLF13chr15

31664213

+
In-frameENST00000503788ENST00000307145MARCH6chr5

10354029

+KLF13chr15

31664213

+
intron-3CDSENST00000510792ENST00000307145MARCH6chr5

10354029

+KLF13chr15

31664213

+
intron-3CDSENST00000510792ENST00000560473MARCH6chr5

10354029

+KLF13chr15

31664213

+
intron-3CDSENST00000606497ENST00000307145MARCH6chr5

10354029

+KLF13chr15

31664213

+
intron-3CDSENST00000606497ENST00000560473MARCH6chr5

10354029

+KLF13chr15

31664213

+
intron-intronENST00000510792ENST00000500533MARCH6chr5

10354029

+KLF13chr15

31664213

+
intron-intronENST00000606497ENST00000500533MARCH6chr5

10354029

+KLF13chr15

31664213

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000449913MARCH6chr510354029+ENST00000307145KLF13chr1531664213+610521529072221228
ENST00000503788MARCH6chr510354029+ENST00000307145KLF13chr1531664213+609220228942208228
ENST00000274140MARCH6chr510354029+ENST00000307145KLF13chr1531664213+604115128432157228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000449913ENST00000307145MARCH6chr510354029+KLF13chr1531664213+0.54386880.45613122
ENST00000503788ENST00000307145MARCH6chr510354029+KLF13chr1531664213+0.54126310.45873693
ENST00000274140ENST00000307145MARCH6chr510354029+KLF13chr1531664213+0.526925740.4730743

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Fusion Genomic Features for MARCH6-KLF13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MARCH6-KLF13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:10354029/chr15:31664213)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KLF13

Q9Y2Y9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells. {ECO:0000269|PubMed:11477107}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKLF13chr5:10354029chr15:31664213ENST0000030714502264_287192289.0Compositional biasNote=Ser-rich
TgeneKLF13chr5:10354029chr15:31664213ENST0000030714502197_221192289.0Zinc fingerC2H2-type 2
TgeneKLF13chr5:10354029chr15:31664213ENST0000030714502227_249192289.0Zinc fingerC2H2-type 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126113_1426911.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126164_2836911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+1261_916911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126305_3366911.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126358_3766911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126398_4216911.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126443_4806911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126502_5196911.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126541_6326911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126654_6786911.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126700_7216911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126743_7646911.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126786_8156911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126837_8486911.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126870_9106911.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125113_1426863.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125164_2836863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+1251_916863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125305_3366863.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125358_3766863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125398_4216863.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125443_4806863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125502_5196863.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125541_6326863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125654_6786863.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125700_7216863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125743_7646863.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125786_8156863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125837_8486863.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125870_9106863.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123113_1426806.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123164_2836806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+1231_916806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123305_3366806.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123358_3766806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123398_4216806.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123443_4806806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123502_5196806.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123541_6326806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123654_6786806.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123700_7216806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123743_7646806.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123786_8156806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123837_8486806.0Topological domainExtracellular
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123870_9106806.0Topological domainCytoplasmic
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126143_1636911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126284_3046911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126337_3576911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126377_3976911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126422_4426911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126481_5016911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126520_5406911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126633_6536911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126679_6996911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126722_7426911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126765_7856911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126816_8366911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+126849_8696911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+12692_1126911.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125143_1636863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125284_3046863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125337_3576863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125377_3976863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125422_4426863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125481_5016863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125520_5406863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125633_6536863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125679_6996863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125722_7426863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125765_7856863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125816_8366863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+125849_8696863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+12592_1126863.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123143_1636806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123284_3046806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123337_3576806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123377_3976806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123422_4426806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123481_5016806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123520_5406806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123633_6536806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123679_6996806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123722_7426806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123765_7856806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123816_8366806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+123849_8696806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+12392_1126806.0TransmembraneHelical
HgeneMARCH6chr5:10354029chr15:31664213ENST00000274140+1261_626911.0Zinc fingerRING-CH-type
HgeneMARCH6chr5:10354029chr15:31664213ENST00000449913+1251_626863.0Zinc fingerRING-CH-type
HgeneMARCH6chr5:10354029chr15:31664213ENST00000503788+1231_626806.0Zinc fingerRING-CH-type
TgeneKLF13chr5:10354029chr15:31664213ENST0000030714502113_116192289.0Compositional biasNote=Poly-Ala
TgeneKLF13chr5:10354029chr15:31664213ENST0000030714502148_168192289.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneKLF13chr5:10354029chr15:31664213ENST00000307145022_145192289.0Compositional biasNote=Ala/Pro-rich
TgeneKLF13chr5:10354029chr15:31664213ENST00000307145022_5192289.0Compositional biasNote=Poly-Ala
TgeneKLF13chr5:10354029chr15:31664213ENST0000030714502167_191192289.0Zinc fingerC2H2-type 1


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Fusion Gene Sequence for MARCH6-KLF13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51700_51700_1_MARCH6-KLF13_MARCH6_chr5_10354029_ENST00000274140_KLF13_chr15_31664213_ENST00000307145_length(transcript)=6041nt_BP=151nt
CCTCTCGCTTCCTCTCTCGCACCTGAGCGTACGCACCTGCCCGGGCCCGGCTCCCTCCTCCTCTCCCCTCCCTCTTTCCCCGCCCGGCCG
CGGGAGCCTCGTGGCTGCGTCACCGCCGCCCCCCCAGACAAGATGGACACCGCGGAGGAAGGTGAGAGGCCCTTCGCCTGCAGCTGGCAG
GACTGCAACAAGAAGTTCGCGCGCTCCGACGAGCTGGCGCGGCACTACCGCACACACACGGGCGAGAAGAAGTTCAGCTGCCCCATCTGC
GAGAAGCGCTTCATGCGCAGCGACCACCTGACCAAGCACGCGCGCCGCCACGCCAACTTCCACCCGGGAATGCTGCAGCGGCGCGGCGGG
GGCTCGCGGACCGGCTCCCTCAGCGACTACAGCCGCTCCGACGCCAGCAGCCCCACCATCAGCCCGGCCAGCTCGCCCTGAGCCCGCCAC
AGCCATGAGCAGCCGCTCCCACCCCCTCGTGAGTCCCTGGCCTTTCCTTTTGTAATAAGAAAGAAGAGAGAGAACTTGATGCAAAGTCCA
CGAAAAAACAATTTTTTTCACCTCAGGTGTCAAAGTAAATTTGTTAAAAAAACAAAAAAAACACAAAAATTTCAAAAAACACCACCCACC
AAATTGCACAATAGATACACCCACAAAGTTGAGATTCAGCGTTGTTGAACCCCCTTTCTCAGGGATGGACACGTTTCACGAGGTCAGTGA
GGACACCCCTTCCTGCCGCCTTACTCTGTACATAGATTTGCACTCTGGAGTTTTCTGTTAGGTTCGGGAACACGCTGGGGACAGAGCAGG
CCAGCCAGTCTGGTGGAGCTCAGCGTCTGGCTGGCTGGCCAGCCTGTGGGTCTGTTGGGAGCAGATGTGCTCACTGACGTTTGTGCCTCC
AGGGCAGATTCCTAAGCAGCTGGCCTGACCTCTTCCTGCCCAGCCCCCAACCCAGTCTCTGGCCTCTGCCCAACGAGCCTGGCTGGGCTT
GCAACGCAGCTGATTCTGAGACAGGCCCCTGCAGAGGGATGCCTTAAAGCTGTCCCTGGCTGGAGGAGCACTCCACCTTGGGGATAGTGG
AGGGGGCCTTCAGCCCTCTGCACCCTGCCTGCCTCACACCCCGCCTTCAGGAGCCCTCTCCTACGGCGCTAGGGAGCACTGGAAGCAGAG
ATGCCAGCCCTGGCTGAGCGTAGCACTGCACCGTCCGACCTCCGAGGCAGGGGCCGGGGTCACACCTGCCAGGACTCCGCTTCTCCGTGT
CCCAGCAGAAGGCATGCAGGACCCTGTCACTACTATACCTGGGCCTCTGATGGGGAATTCTGGTCTTCTAAAAAGATGTTAGAAATTCCT
GGTGGCACATCCAGTTCCGAGTTTGCCCGCACGGGCACTTTTGTTGGAAACAGTGGGCAGGTCATGGGGCCTCCTCATCAGAGGGTCTGT
GTGAGCGGCTGTGCATGTGGCAGCGCACCATGCTTCACAGAGACCATTCTGTAGCAAGAGACCGGAACATTGTGACTTGGACCTTTTCAG
GAGTGGCGCGGATGTTACAGGAAATGCTGTCGGAGAGCGCGCATTCTATTTCCTCCGCAGGGAATGCCAGATAGAAAGTTGCGGGCAACA
CTTTTCTCAGACCCACCATGTCCCCAACTCAGACTTAGCAAACCTCCAGCCTCTCCGTTTCCCCTGGACTCCTCCTCCCTTTTCCTCCTG
CTTCTCCTTGTCCTGCCTGGAGGCTCCAGGCCACACCCAGCTGGTGGGGCTGCTCCAGTGCCCCATCACCGGCCTTCTCCTGGCAGGAGA
GGAGGAGCAGAGAGCTGGGTCCTGGGCTGGGATTCGAGCCCTGGGCGGGGGTCAGTCAAGCCGTGGTCCAGCAAACTCCTCTGCAGATGG
CTGGAGTGTTGACCCAGGCTTGTGGCCCAGGTATCACCTTCCCTTCCTCCTGAGAGTTGAGGCCTGTAAATACAAGGGCCCAGGACAGAG
TGTGTGCGTGCGTGTGGGTGTGTGCGCGCGTGAGCACACACGCGTGTGTTGGGGGGGGTGGGGGGATTGGGGTGGACTCAGGGTATCTTG
CCAGAGATACCTGTTTTGATGAGTACCTATTTTGATGCAAAGGAACGGCCCTGGGACCTCAGAGGGCCACAGATGGGCTTCCTGGGCCTA
GCGTGCCTTGGTTGTGGCCATCCTGCTTCTACTCAGCCCTGCCATGCTATGGGGTGCAGCACAAACCCAGGACCCAGGCCTAGCCACTGC
CCACAGCTGATGGTCACTGTTTTGGCTGGCTCCAGAGTGGACAGGTACGCTCTGTCCACAGCAGCTGCTCAGGCACAGTATGCCGTCAGG
TGCCCGCTTCTTACCACTGTGTGTCAGCTGGGATTGGCCGACAGCGTGGTGGTGACTTCTAGGTAGACCGATGGACCCTAAATTGGGCAG
TGGCATTGTTTCTGCTGTGGTGGGAACTGGCAGGGAGAGGGTCACCTCCACTCTGGTTGGATGCGGAGCTGGTCCCTCTGGCTGCCATGC
TGTGTTGGGGCTCTCTGACCTCCCTGCTTGCATTGGGTCTGGGAGAGAGAGTGGAATATTTGGTAGGGACCTTGACAGAAGAGAGCCCTG
GGTGCTTGTGGTGCAAAGATCTTCATGCCCAGTTCCAAAGTGAGGTCCCTCCCAAAGTTGTTTTCGTGTGAGGCAGAGAAAGCCACACTC
TGAATACATTTTATGTCTCAGGAATTCACATTCCAGGTTCAGGAATTTTATTCCAAAGTCCTTTGGTGCACTCACCGTCCACCGTTCCCC
AAGGCAGGGAGAGGGAGTGGCCCGTCCCTGGGAGGCTGGCAAAGTGCTCTCCAGGGAGGGGTCAGACGTCCTTGTGATCTGCCCAGGGTG
TCACGGAAGGAGATTTTCTAGCTCCACATCTGTCTGCACATAGGAAGGAAAAGATAGGACTCTAAACCTAGTCATCTTGGAATAAAAAGA
AGAGCTGGTTTGTTTTAGAGCAGGGCGGGGGGTGGGGGAGGGAAGCGGGTGTTGGCTGTTTCCAAAGAGAGCACTTAATTTAATTTTTCC
TTTAAATGACCCAGGGCTGTTCCGTCTGATAGATGGAAGGGTAACATTGCCTTAAAACAGAAATATGCAGGCGTTGGCTATTTTTGGCAT
AAGAGCGTGTCTTCATTCCCAAAGTGGTTCTCGTTTAATGGCAGGGTGCGGTCCTTAGGCCCCGGCCTGGACTGGGAAATGGGGGTAGGG
CACCAGGAGAGAAATCCTCCTGGGTACTCCTGGCCAGACCCTCCTGAATCATCTGCGGCTTAAACTCATCTCGCTTGAAGGGCAGGGAGA
AACCCATGAATCTCAGGCACGGTTCACAGGGGTCCTCAAGGGCAGGTTTCCATTTCATCATGAAGTGAGGGACTCCTGTGGAAGAGGGTG
GTGGGCCTTGGAACGCTGCCTCCACTGAGGCGGGCACACAAGGCGGACCCTCCTGAAACAGCCTCCATTTTCTTCAAACATGCAGAATGT
TTTCCCAGACTGCGTCTATTTCAGGGTCTTCCATTTTTGTGGTTTATGGCCATGCTTGCCAGTTTTGGTGGGGTTGAGGAACCCATAGGA
CTCATAGAAATAATAGTGAAAACTCAAACCCTTATTTTGGGACTTCAGTTCTCGTGGTCCATAGGGGCAGAGATGTCAAAGTGAAGGTTG
CCTGAGTGAAGGGAGAGTTCCCCTATAAAAGGCCTAAAATTGATCTGGGGCTCAGCCATCAAGGGGCTGGTGTTGCTCCTGTCCCAGACA
AGGAAGCCCCTCTTTACATCAGCCATATTAGGGGAACGGTTGTCAGCTCCCCAAATGCCTACTGGATCCTACAGCCATACAGGAAAACAG
ACGGACACAGCCCTTTCCTTAAAGAGCCCTGGGGTCCTGTCCTGCAGGATGCTGCATAGGAATGGGCAGAGATGTCCTGGATGGGAACAT
GGTCCTGGAGGTGCCCTACCTGCATCCTGCTGCACCCCCACCCACGACACTCGAGTGCAAGATCGCCTCACTCCTAACCCTGACTTTATT
CCCAGGCCCCACACCGAGGCAGGTGCAGGATTCGCCATGGTGCAGCCTCCGGGTACAAACATCTGAGGCACTGGCGATCCCAGTCCTTGC
AGCACCCTGAACACAGCTCAGACCAGTGAGGGGTGATTCAGAGGTGGGGATGGGCAGAGAGGGCTGGCCACTCTGCCTCAGGACTTGACC
TCAAGTGTTCTGTCTCCCCACCCGGTGTGTCCAGAAGACCAGCCTCTTTCTTGCCAGAAGCAGGTGCTAAGATGGACTGCACAGGGTCCC
GGCACTCCCTCGGGACCCATTCAGGATCTCAGCTGGGCAGGGGTGCCACCCAACAGGAAGATGTGATCTGAGCAATAGTGTGGCCTTGTT
TCTCCGCTTCTGGTTGTGGCTGTGTGTACAGGGCTACCTATTTTGACTTCTGACAGGTGTCACTGATTTTCTTTCCCCCATTTAAAAAAG
GTCATTTAGTCAAAGACACAGTGCTAGAGGTTTAAAGGGTGTAATGTGTTGGTCACATCACAACCAGTAAGAAACGCTTGGTAGGTTATC
CACATCTTTTGCTGACTGTTTCCATATACAATTCTGGTCACCATATTTTCCAAAGCTAAAATCTGAGGCGTGGGCTGATGGTTTTTGAAA
TCAGGATTACCCCAGGAAGAACCAGGTCCTATTACTAATTTTCCTGATTCTGAGGCTCTGAAGGCTTGTCTGAGACACATTCCGGAGACC
TTTGTACCAGAACTTGGATGCATAGTCCACCTTACTACTGATACACGCCTGAGCACCCTTTAGGGCGAGGCGCCGCCTCCTGCCTGCTGT
CCTGTCCCTCAGCATCAGAAGAGTTGAATTCAGCAGGAGACGGGAGCCCGGTGTCCATGAGGGAAGAGGGGTCGCGCTTGGTTTCTACTG
ACCCCCATGAAGATTTCAGACTTGCAGTGCGGCCACCTGGCCCTGCCCTGCCTCTCTCTTTCTCATACAGCTTTAAAACTTTACTACTTT
TATTTAAAAATGAACTGGATGGGAGAGAAGTAGCGTCCCCTACCCTACAAGTCACACATTCCGGGGAGGGGGGTGGGGGGTGGAGGCAGG
AAGTCATGGGGGTGGGGGTGGGAGCACGGGAACAGCTTTCTTAAGGCCTCAGGGTCCTGTTTTCCCTGGCCTCTTCTAGAGGGCCCGTGG
ACAGGTCGCAGTGCGTGCTTATTTGGAAACCAGGTGTGTGAGCCGAATGCCTGCCAGGCCATGCACTCAGCAGAGGAGCCCTTGTACCTG
GCTGCCCTGAGAGGAGCAAGAGGCCACCTCCCATGTGGCTCTAGACACCACGTGGGCTCATTAGCCCCAGCGTCTGTGCCGGCTCCAGGT
GCCTGCCTCTGGGTGTGTGAGTGGGAGACTTTGCTCCCTGGCCTCATCCTAGAGAGGCCCCTGGTGCCTAGTGCTGAGGCCTCTGGGGCT
GGAAAGCCTCAGCAGAAAGGAGGCACTACTGAGCAACTATGCATTGTCATTGTCGGGTTTGGGGCTTTCGGTGGTTCCTTGGTGACTGGG
AATTGCTTGTGTGCATGTGTTGGGTGCATGCTTCCGGGTCTCAGCTGCCCCAGGCCCGCACAGGCAACCCCTTCCCATCCAAAGCCATTG
GTGGAGCTTCTCTGGAATCATTTGCCAAAAGCCCAAGGCAGAATCCAAGGGTCCAAGACCATTTCCATGGAGCTCATGTTTTTCTTTTCT
GTAGGAACTTTTTTTTAACCAGCACCCACCATAATTCCGAAGGCCACGTTTCATCTTTCCTGGATCACTACAGTGAAGTATTACAGTTGT
ACAGTTCCCAGTCTGGCCTTGGCTTGCTCGGATAAAACTTTGTATGTATTTTGTATGGCATAGATTCTATATTGTAATGATGTCCTATGC
AAAAAGAAAAATTAACGAAATTGTAAATTTTATTGTTTTAACGTGTATGCATGTTTAGTGACGTTTACATTTTGAAATAAAATTTATGAT

>51700_51700_1_MARCH6-KLF13_MARCH6_chr5_10354029_ENST00000274140_KLF13_chr15_31664213_ENST00000307145_length(amino acids)=228AA_BP=
MESTLPASQGRATPSPCLGERWTVSAPKDFGIKFLNLECEFLRHKMYSECGFLCLTRKQLWEGPHFGTGHEDLCTTSTQGSLLSRSLPNI
PLSLPDPMQAGRSESPNTAWQPEGPAPHPTRVEVTLSLPVPTTAETMPLPNLGSIGLPRSHHHAVGQSQLTHSGKKRAPDGILCLSSCCG

--------------------------------------------------------------
>51700_51700_2_MARCH6-KLF13_MARCH6_chr5_10354029_ENST00000449913_KLF13_chr15_31664213_ENST00000307145_length(transcript)=6105nt_BP=215nt
CCCTCCCCCTCCCGTGTCGCTCGCTTTCTGTCAGCCTCTCTCCCTCTCCCTCTCCCCTCTCCTTCCTCTCGCTTCCTCTCTCGCACCTGA
GCGTACGCACCTGCCCGGGCCCGGCTCCCTCCTCCTCTCCCCTCCCTCTTTCCCCGCCCGGCCGCGGGAGCCTCGTGGCTGCGTCACCGC
CGCCCCCCCAGACAAGATGGACACCGCGGAGGAAGGTGAGAGGCCCTTCGCCTGCAGCTGGCAGGACTGCAACAAGAAGTTCGCGCGCTC
CGACGAGCTGGCGCGGCACTACCGCACACACACGGGCGAGAAGAAGTTCAGCTGCCCCATCTGCGAGAAGCGCTTCATGCGCAGCGACCA
CCTGACCAAGCACGCGCGCCGCCACGCCAACTTCCACCCGGGAATGCTGCAGCGGCGCGGCGGGGGCTCGCGGACCGGCTCCCTCAGCGA
CTACAGCCGCTCCGACGCCAGCAGCCCCACCATCAGCCCGGCCAGCTCGCCCTGAGCCCGCCACAGCCATGAGCAGCCGCTCCCACCCCC
TCGTGAGTCCCTGGCCTTTCCTTTTGTAATAAGAAAGAAGAGAGAGAACTTGATGCAAAGTCCACGAAAAAACAATTTTTTTCACCTCAG
GTGTCAAAGTAAATTTGTTAAAAAAACAAAAAAAACACAAAAATTTCAAAAAACACCACCCACCAAATTGCACAATAGATACACCCACAA
AGTTGAGATTCAGCGTTGTTGAACCCCCTTTCTCAGGGATGGACACGTTTCACGAGGTCAGTGAGGACACCCCTTCCTGCCGCCTTACTC
TGTACATAGATTTGCACTCTGGAGTTTTCTGTTAGGTTCGGGAACACGCTGGGGACAGAGCAGGCCAGCCAGTCTGGTGGAGCTCAGCGT
CTGGCTGGCTGGCCAGCCTGTGGGTCTGTTGGGAGCAGATGTGCTCACTGACGTTTGTGCCTCCAGGGCAGATTCCTAAGCAGCTGGCCT
GACCTCTTCCTGCCCAGCCCCCAACCCAGTCTCTGGCCTCTGCCCAACGAGCCTGGCTGGGCTTGCAACGCAGCTGATTCTGAGACAGGC
CCCTGCAGAGGGATGCCTTAAAGCTGTCCCTGGCTGGAGGAGCACTCCACCTTGGGGATAGTGGAGGGGGCCTTCAGCCCTCTGCACCCT
GCCTGCCTCACACCCCGCCTTCAGGAGCCCTCTCCTACGGCGCTAGGGAGCACTGGAAGCAGAGATGCCAGCCCTGGCTGAGCGTAGCAC
TGCACCGTCCGACCTCCGAGGCAGGGGCCGGGGTCACACCTGCCAGGACTCCGCTTCTCCGTGTCCCAGCAGAAGGCATGCAGGACCCTG
TCACTACTATACCTGGGCCTCTGATGGGGAATTCTGGTCTTCTAAAAAGATGTTAGAAATTCCTGGTGGCACATCCAGTTCCGAGTTTGC
CCGCACGGGCACTTTTGTTGGAAACAGTGGGCAGGTCATGGGGCCTCCTCATCAGAGGGTCTGTGTGAGCGGCTGTGCATGTGGCAGCGC
ACCATGCTTCACAGAGACCATTCTGTAGCAAGAGACCGGAACATTGTGACTTGGACCTTTTCAGGAGTGGCGCGGATGTTACAGGAAATG
CTGTCGGAGAGCGCGCATTCTATTTCCTCCGCAGGGAATGCCAGATAGAAAGTTGCGGGCAACACTTTTCTCAGACCCACCATGTCCCCA
ACTCAGACTTAGCAAACCTCCAGCCTCTCCGTTTCCCCTGGACTCCTCCTCCCTTTTCCTCCTGCTTCTCCTTGTCCTGCCTGGAGGCTC
CAGGCCACACCCAGCTGGTGGGGCTGCTCCAGTGCCCCATCACCGGCCTTCTCCTGGCAGGAGAGGAGGAGCAGAGAGCTGGGTCCTGGG
CTGGGATTCGAGCCCTGGGCGGGGGTCAGTCAAGCCGTGGTCCAGCAAACTCCTCTGCAGATGGCTGGAGTGTTGACCCAGGCTTGTGGC
CCAGGTATCACCTTCCCTTCCTCCTGAGAGTTGAGGCCTGTAAATACAAGGGCCCAGGACAGAGTGTGTGCGTGCGTGTGGGTGTGTGCG
CGCGTGAGCACACACGCGTGTGTTGGGGGGGGTGGGGGGATTGGGGTGGACTCAGGGTATCTTGCCAGAGATACCTGTTTTGATGAGTAC
CTATTTTGATGCAAAGGAACGGCCCTGGGACCTCAGAGGGCCACAGATGGGCTTCCTGGGCCTAGCGTGCCTTGGTTGTGGCCATCCTGC
TTCTACTCAGCCCTGCCATGCTATGGGGTGCAGCACAAACCCAGGACCCAGGCCTAGCCACTGCCCACAGCTGATGGTCACTGTTTTGGC
TGGCTCCAGAGTGGACAGGTACGCTCTGTCCACAGCAGCTGCTCAGGCACAGTATGCCGTCAGGTGCCCGCTTCTTACCACTGTGTGTCA
GCTGGGATTGGCCGACAGCGTGGTGGTGACTTCTAGGTAGACCGATGGACCCTAAATTGGGCAGTGGCATTGTTTCTGCTGTGGTGGGAA
CTGGCAGGGAGAGGGTCACCTCCACTCTGGTTGGATGCGGAGCTGGTCCCTCTGGCTGCCATGCTGTGTTGGGGCTCTCTGACCTCCCTG
CTTGCATTGGGTCTGGGAGAGAGAGTGGAATATTTGGTAGGGACCTTGACAGAAGAGAGCCCTGGGTGCTTGTGGTGCAAAGATCTTCAT
GCCCAGTTCCAAAGTGAGGTCCCTCCCAAAGTTGTTTTCGTGTGAGGCAGAGAAAGCCACACTCTGAATACATTTTATGTCTCAGGAATT
CACATTCCAGGTTCAGGAATTTTATTCCAAAGTCCTTTGGTGCACTCACCGTCCACCGTTCCCCAAGGCAGGGAGAGGGAGTGGCCCGTC
CCTGGGAGGCTGGCAAAGTGCTCTCCAGGGAGGGGTCAGACGTCCTTGTGATCTGCCCAGGGTGTCACGGAAGGAGATTTTCTAGCTCCA
CATCTGTCTGCACATAGGAAGGAAAAGATAGGACTCTAAACCTAGTCATCTTGGAATAAAAAGAAGAGCTGGTTTGTTTTAGAGCAGGGC
GGGGGGTGGGGGAGGGAAGCGGGTGTTGGCTGTTTCCAAAGAGAGCACTTAATTTAATTTTTCCTTTAAATGACCCAGGGCTGTTCCGTC
TGATAGATGGAAGGGTAACATTGCCTTAAAACAGAAATATGCAGGCGTTGGCTATTTTTGGCATAAGAGCGTGTCTTCATTCCCAAAGTG
GTTCTCGTTTAATGGCAGGGTGCGGTCCTTAGGCCCCGGCCTGGACTGGGAAATGGGGGTAGGGCACCAGGAGAGAAATCCTCCTGGGTA
CTCCTGGCCAGACCCTCCTGAATCATCTGCGGCTTAAACTCATCTCGCTTGAAGGGCAGGGAGAAACCCATGAATCTCAGGCACGGTTCA
CAGGGGTCCTCAAGGGCAGGTTTCCATTTCATCATGAAGTGAGGGACTCCTGTGGAAGAGGGTGGTGGGCCTTGGAACGCTGCCTCCACT
GAGGCGGGCACACAAGGCGGACCCTCCTGAAACAGCCTCCATTTTCTTCAAACATGCAGAATGTTTTCCCAGACTGCGTCTATTTCAGGG
TCTTCCATTTTTGTGGTTTATGGCCATGCTTGCCAGTTTTGGTGGGGTTGAGGAACCCATAGGACTCATAGAAATAATAGTGAAAACTCA
AACCCTTATTTTGGGACTTCAGTTCTCGTGGTCCATAGGGGCAGAGATGTCAAAGTGAAGGTTGCCTGAGTGAAGGGAGAGTTCCCCTAT
AAAAGGCCTAAAATTGATCTGGGGCTCAGCCATCAAGGGGCTGGTGTTGCTCCTGTCCCAGACAAGGAAGCCCCTCTTTACATCAGCCAT
ATTAGGGGAACGGTTGTCAGCTCCCCAAATGCCTACTGGATCCTACAGCCATACAGGAAAACAGACGGACACAGCCCTTTCCTTAAAGAG
CCCTGGGGTCCTGTCCTGCAGGATGCTGCATAGGAATGGGCAGAGATGTCCTGGATGGGAACATGGTCCTGGAGGTGCCCTACCTGCATC
CTGCTGCACCCCCACCCACGACACTCGAGTGCAAGATCGCCTCACTCCTAACCCTGACTTTATTCCCAGGCCCCACACCGAGGCAGGTGC
AGGATTCGCCATGGTGCAGCCTCCGGGTACAAACATCTGAGGCACTGGCGATCCCAGTCCTTGCAGCACCCTGAACACAGCTCAGACCAG
TGAGGGGTGATTCAGAGGTGGGGATGGGCAGAGAGGGCTGGCCACTCTGCCTCAGGACTTGACCTCAAGTGTTCTGTCTCCCCACCCGGT
GTGTCCAGAAGACCAGCCTCTTTCTTGCCAGAAGCAGGTGCTAAGATGGACTGCACAGGGTCCCGGCACTCCCTCGGGACCCATTCAGGA
TCTCAGCTGGGCAGGGGTGCCACCCAACAGGAAGATGTGATCTGAGCAATAGTGTGGCCTTGTTTCTCCGCTTCTGGTTGTGGCTGTGTG
TACAGGGCTACCTATTTTGACTTCTGACAGGTGTCACTGATTTTCTTTCCCCCATTTAAAAAAGGTCATTTAGTCAAAGACACAGTGCTA
GAGGTTTAAAGGGTGTAATGTGTTGGTCACATCACAACCAGTAAGAAACGCTTGGTAGGTTATCCACATCTTTTGCTGACTGTTTCCATA
TACAATTCTGGTCACCATATTTTCCAAAGCTAAAATCTGAGGCGTGGGCTGATGGTTTTTGAAATCAGGATTACCCCAGGAAGAACCAGG
TCCTATTACTAATTTTCCTGATTCTGAGGCTCTGAAGGCTTGTCTGAGACACATTCCGGAGACCTTTGTACCAGAACTTGGATGCATAGT
CCACCTTACTACTGATACACGCCTGAGCACCCTTTAGGGCGAGGCGCCGCCTCCTGCCTGCTGTCCTGTCCCTCAGCATCAGAAGAGTTG
AATTCAGCAGGAGACGGGAGCCCGGTGTCCATGAGGGAAGAGGGGTCGCGCTTGGTTTCTACTGACCCCCATGAAGATTTCAGACTTGCA
GTGCGGCCACCTGGCCCTGCCCTGCCTCTCTCTTTCTCATACAGCTTTAAAACTTTACTACTTTTATTTAAAAATGAACTGGATGGGAGA
GAAGTAGCGTCCCCTACCCTACAAGTCACACATTCCGGGGAGGGGGGTGGGGGGTGGAGGCAGGAAGTCATGGGGGTGGGGGTGGGAGCA
CGGGAACAGCTTTCTTAAGGCCTCAGGGTCCTGTTTTCCCTGGCCTCTTCTAGAGGGCCCGTGGACAGGTCGCAGTGCGTGCTTATTTGG
AAACCAGGTGTGTGAGCCGAATGCCTGCCAGGCCATGCACTCAGCAGAGGAGCCCTTGTACCTGGCTGCCCTGAGAGGAGCAAGAGGCCA
CCTCCCATGTGGCTCTAGACACCACGTGGGCTCATTAGCCCCAGCGTCTGTGCCGGCTCCAGGTGCCTGCCTCTGGGTGTGTGAGTGGGA
GACTTTGCTCCCTGGCCTCATCCTAGAGAGGCCCCTGGTGCCTAGTGCTGAGGCCTCTGGGGCTGGAAAGCCTCAGCAGAAAGGAGGCAC
TACTGAGCAACTATGCATTGTCATTGTCGGGTTTGGGGCTTTCGGTGGTTCCTTGGTGACTGGGAATTGCTTGTGTGCATGTGTTGGGTG
CATGCTTCCGGGTCTCAGCTGCCCCAGGCCCGCACAGGCAACCCCTTCCCATCCAAAGCCATTGGTGGAGCTTCTCTGGAATCATTTGCC
AAAAGCCCAAGGCAGAATCCAAGGGTCCAAGACCATTTCCATGGAGCTCATGTTTTTCTTTTCTGTAGGAACTTTTTTTTAACCAGCACC
CACCATAATTCCGAAGGCCACGTTTCATCTTTCCTGGATCACTACAGTGAAGTATTACAGTTGTACAGTTCCCAGTCTGGCCTTGGCTTG
CTCGGATAAAACTTTGTATGTATTTTGTATGGCATAGATTCTATATTGTAATGATGTCCTATGCAAAAAGAAAAATTAACGAAATTGTAA

>51700_51700_2_MARCH6-KLF13_MARCH6_chr5_10354029_ENST00000449913_KLF13_chr15_31664213_ENST00000307145_length(amino acids)=228AA_BP=
MESTLPASQGRATPSPCLGERWTVSAPKDFGIKFLNLECEFLRHKMYSECGFLCLTRKQLWEGPHFGTGHEDLCTTSTQGSLLSRSLPNI
PLSLPDPMQAGRSESPNTAWQPEGPAPHPTRVEVTLSLPVPTTAETMPLPNLGSIGLPRSHHHAVGQSQLTHSGKKRAPDGILCLSSCCG

--------------------------------------------------------------
>51700_51700_3_MARCH6-KLF13_MARCH6_chr5_10354029_ENST00000503788_KLF13_chr15_31664213_ENST00000307145_length(transcript)=6092nt_BP=202nt
GTGTCGCTCGCTTTCTGTCAGCCTCTCTCCCTCTCCCTCTCCCCTCTCCTTCCTCTCGCTTCCTCTCTCGCACCTGAGCGTACGCACCTG
CCCGGGCCCGGCTCCCTCCTCCTCTCCCCTCCCTCTTTCCCCGCCCGGCCGCGGGAGCCTCGTGGCTGCGTCACCGCCGCCCCCCCAGAC
AAGATGGACACCGCGGAGGAAGGTGAGAGGCCCTTCGCCTGCAGCTGGCAGGACTGCAACAAGAAGTTCGCGCGCTCCGACGAGCTGGCG
CGGCACTACCGCACACACACGGGCGAGAAGAAGTTCAGCTGCCCCATCTGCGAGAAGCGCTTCATGCGCAGCGACCACCTGACCAAGCAC
GCGCGCCGCCACGCCAACTTCCACCCGGGAATGCTGCAGCGGCGCGGCGGGGGCTCGCGGACCGGCTCCCTCAGCGACTACAGCCGCTCC
GACGCCAGCAGCCCCACCATCAGCCCGGCCAGCTCGCCCTGAGCCCGCCACAGCCATGAGCAGCCGCTCCCACCCCCTCGTGAGTCCCTG
GCCTTTCCTTTTGTAATAAGAAAGAAGAGAGAGAACTTGATGCAAAGTCCACGAAAAAACAATTTTTTTCACCTCAGGTGTCAAAGTAAA
TTTGTTAAAAAAACAAAAAAAACACAAAAATTTCAAAAAACACCACCCACCAAATTGCACAATAGATACACCCACAAAGTTGAGATTCAG
CGTTGTTGAACCCCCTTTCTCAGGGATGGACACGTTTCACGAGGTCAGTGAGGACACCCCTTCCTGCCGCCTTACTCTGTACATAGATTT
GCACTCTGGAGTTTTCTGTTAGGTTCGGGAACACGCTGGGGACAGAGCAGGCCAGCCAGTCTGGTGGAGCTCAGCGTCTGGCTGGCTGGC
CAGCCTGTGGGTCTGTTGGGAGCAGATGTGCTCACTGACGTTTGTGCCTCCAGGGCAGATTCCTAAGCAGCTGGCCTGACCTCTTCCTGC
CCAGCCCCCAACCCAGTCTCTGGCCTCTGCCCAACGAGCCTGGCTGGGCTTGCAACGCAGCTGATTCTGAGACAGGCCCCTGCAGAGGGA
TGCCTTAAAGCTGTCCCTGGCTGGAGGAGCACTCCACCTTGGGGATAGTGGAGGGGGCCTTCAGCCCTCTGCACCCTGCCTGCCTCACAC
CCCGCCTTCAGGAGCCCTCTCCTACGGCGCTAGGGAGCACTGGAAGCAGAGATGCCAGCCCTGGCTGAGCGTAGCACTGCACCGTCCGAC
CTCCGAGGCAGGGGCCGGGGTCACACCTGCCAGGACTCCGCTTCTCCGTGTCCCAGCAGAAGGCATGCAGGACCCTGTCACTACTATACC
TGGGCCTCTGATGGGGAATTCTGGTCTTCTAAAAAGATGTTAGAAATTCCTGGTGGCACATCCAGTTCCGAGTTTGCCCGCACGGGCACT
TTTGTTGGAAACAGTGGGCAGGTCATGGGGCCTCCTCATCAGAGGGTCTGTGTGAGCGGCTGTGCATGTGGCAGCGCACCATGCTTCACA
GAGACCATTCTGTAGCAAGAGACCGGAACATTGTGACTTGGACCTTTTCAGGAGTGGCGCGGATGTTACAGGAAATGCTGTCGGAGAGCG
CGCATTCTATTTCCTCCGCAGGGAATGCCAGATAGAAAGTTGCGGGCAACACTTTTCTCAGACCCACCATGTCCCCAACTCAGACTTAGC
AAACCTCCAGCCTCTCCGTTTCCCCTGGACTCCTCCTCCCTTTTCCTCCTGCTTCTCCTTGTCCTGCCTGGAGGCTCCAGGCCACACCCA
GCTGGTGGGGCTGCTCCAGTGCCCCATCACCGGCCTTCTCCTGGCAGGAGAGGAGGAGCAGAGAGCTGGGTCCTGGGCTGGGATTCGAGC
CCTGGGCGGGGGTCAGTCAAGCCGTGGTCCAGCAAACTCCTCTGCAGATGGCTGGAGTGTTGACCCAGGCTTGTGGCCCAGGTATCACCT
TCCCTTCCTCCTGAGAGTTGAGGCCTGTAAATACAAGGGCCCAGGACAGAGTGTGTGCGTGCGTGTGGGTGTGTGCGCGCGTGAGCACAC
ACGCGTGTGTTGGGGGGGGTGGGGGGATTGGGGTGGACTCAGGGTATCTTGCCAGAGATACCTGTTTTGATGAGTACCTATTTTGATGCA
AAGGAACGGCCCTGGGACCTCAGAGGGCCACAGATGGGCTTCCTGGGCCTAGCGTGCCTTGGTTGTGGCCATCCTGCTTCTACTCAGCCC
TGCCATGCTATGGGGTGCAGCACAAACCCAGGACCCAGGCCTAGCCACTGCCCACAGCTGATGGTCACTGTTTTGGCTGGCTCCAGAGTG
GACAGGTACGCTCTGTCCACAGCAGCTGCTCAGGCACAGTATGCCGTCAGGTGCCCGCTTCTTACCACTGTGTGTCAGCTGGGATTGGCC
GACAGCGTGGTGGTGACTTCTAGGTAGACCGATGGACCCTAAATTGGGCAGTGGCATTGTTTCTGCTGTGGTGGGAACTGGCAGGGAGAG
GGTCACCTCCACTCTGGTTGGATGCGGAGCTGGTCCCTCTGGCTGCCATGCTGTGTTGGGGCTCTCTGACCTCCCTGCTTGCATTGGGTC
TGGGAGAGAGAGTGGAATATTTGGTAGGGACCTTGACAGAAGAGAGCCCTGGGTGCTTGTGGTGCAAAGATCTTCATGCCCAGTTCCAAA
GTGAGGTCCCTCCCAAAGTTGTTTTCGTGTGAGGCAGAGAAAGCCACACTCTGAATACATTTTATGTCTCAGGAATTCACATTCCAGGTT
CAGGAATTTTATTCCAAAGTCCTTTGGTGCACTCACCGTCCACCGTTCCCCAAGGCAGGGAGAGGGAGTGGCCCGTCCCTGGGAGGCTGG
CAAAGTGCTCTCCAGGGAGGGGTCAGACGTCCTTGTGATCTGCCCAGGGTGTCACGGAAGGAGATTTTCTAGCTCCACATCTGTCTGCAC
ATAGGAAGGAAAAGATAGGACTCTAAACCTAGTCATCTTGGAATAAAAAGAAGAGCTGGTTTGTTTTAGAGCAGGGCGGGGGGTGGGGGA
GGGAAGCGGGTGTTGGCTGTTTCCAAAGAGAGCACTTAATTTAATTTTTCCTTTAAATGACCCAGGGCTGTTCCGTCTGATAGATGGAAG
GGTAACATTGCCTTAAAACAGAAATATGCAGGCGTTGGCTATTTTTGGCATAAGAGCGTGTCTTCATTCCCAAAGTGGTTCTCGTTTAAT
GGCAGGGTGCGGTCCTTAGGCCCCGGCCTGGACTGGGAAATGGGGGTAGGGCACCAGGAGAGAAATCCTCCTGGGTACTCCTGGCCAGAC
CCTCCTGAATCATCTGCGGCTTAAACTCATCTCGCTTGAAGGGCAGGGAGAAACCCATGAATCTCAGGCACGGTTCACAGGGGTCCTCAA
GGGCAGGTTTCCATTTCATCATGAAGTGAGGGACTCCTGTGGAAGAGGGTGGTGGGCCTTGGAACGCTGCCTCCACTGAGGCGGGCACAC
AAGGCGGACCCTCCTGAAACAGCCTCCATTTTCTTCAAACATGCAGAATGTTTTCCCAGACTGCGTCTATTTCAGGGTCTTCCATTTTTG
TGGTTTATGGCCATGCTTGCCAGTTTTGGTGGGGTTGAGGAACCCATAGGACTCATAGAAATAATAGTGAAAACTCAAACCCTTATTTTG
GGACTTCAGTTCTCGTGGTCCATAGGGGCAGAGATGTCAAAGTGAAGGTTGCCTGAGTGAAGGGAGAGTTCCCCTATAAAAGGCCTAAAA
TTGATCTGGGGCTCAGCCATCAAGGGGCTGGTGTTGCTCCTGTCCCAGACAAGGAAGCCCCTCTTTACATCAGCCATATTAGGGGAACGG
TTGTCAGCTCCCCAAATGCCTACTGGATCCTACAGCCATACAGGAAAACAGACGGACACAGCCCTTTCCTTAAAGAGCCCTGGGGTCCTG
TCCTGCAGGATGCTGCATAGGAATGGGCAGAGATGTCCTGGATGGGAACATGGTCCTGGAGGTGCCCTACCTGCATCCTGCTGCACCCCC
ACCCACGACACTCGAGTGCAAGATCGCCTCACTCCTAACCCTGACTTTATTCCCAGGCCCCACACCGAGGCAGGTGCAGGATTCGCCATG
GTGCAGCCTCCGGGTACAAACATCTGAGGCACTGGCGATCCCAGTCCTTGCAGCACCCTGAACACAGCTCAGACCAGTGAGGGGTGATTC
AGAGGTGGGGATGGGCAGAGAGGGCTGGCCACTCTGCCTCAGGACTTGACCTCAAGTGTTCTGTCTCCCCACCCGGTGTGTCCAGAAGAC
CAGCCTCTTTCTTGCCAGAAGCAGGTGCTAAGATGGACTGCACAGGGTCCCGGCACTCCCTCGGGACCCATTCAGGATCTCAGCTGGGCA
GGGGTGCCACCCAACAGGAAGATGTGATCTGAGCAATAGTGTGGCCTTGTTTCTCCGCTTCTGGTTGTGGCTGTGTGTACAGGGCTACCT
ATTTTGACTTCTGACAGGTGTCACTGATTTTCTTTCCCCCATTTAAAAAAGGTCATTTAGTCAAAGACACAGTGCTAGAGGTTTAAAGGG
TGTAATGTGTTGGTCACATCACAACCAGTAAGAAACGCTTGGTAGGTTATCCACATCTTTTGCTGACTGTTTCCATATACAATTCTGGTC
ACCATATTTTCCAAAGCTAAAATCTGAGGCGTGGGCTGATGGTTTTTGAAATCAGGATTACCCCAGGAAGAACCAGGTCCTATTACTAAT
TTTCCTGATTCTGAGGCTCTGAAGGCTTGTCTGAGACACATTCCGGAGACCTTTGTACCAGAACTTGGATGCATAGTCCACCTTACTACT
GATACACGCCTGAGCACCCTTTAGGGCGAGGCGCCGCCTCCTGCCTGCTGTCCTGTCCCTCAGCATCAGAAGAGTTGAATTCAGCAGGAG
ACGGGAGCCCGGTGTCCATGAGGGAAGAGGGGTCGCGCTTGGTTTCTACTGACCCCCATGAAGATTTCAGACTTGCAGTGCGGCCACCTG
GCCCTGCCCTGCCTCTCTCTTTCTCATACAGCTTTAAAACTTTACTACTTTTATTTAAAAATGAACTGGATGGGAGAGAAGTAGCGTCCC
CTACCCTACAAGTCACACATTCCGGGGAGGGGGGTGGGGGGTGGAGGCAGGAAGTCATGGGGGTGGGGGTGGGAGCACGGGAACAGCTTT
CTTAAGGCCTCAGGGTCCTGTTTTCCCTGGCCTCTTCTAGAGGGCCCGTGGACAGGTCGCAGTGCGTGCTTATTTGGAAACCAGGTGTGT
GAGCCGAATGCCTGCCAGGCCATGCACTCAGCAGAGGAGCCCTTGTACCTGGCTGCCCTGAGAGGAGCAAGAGGCCACCTCCCATGTGGC
TCTAGACACCACGTGGGCTCATTAGCCCCAGCGTCTGTGCCGGCTCCAGGTGCCTGCCTCTGGGTGTGTGAGTGGGAGACTTTGCTCCCT
GGCCTCATCCTAGAGAGGCCCCTGGTGCCTAGTGCTGAGGCCTCTGGGGCTGGAAAGCCTCAGCAGAAAGGAGGCACTACTGAGCAACTA
TGCATTGTCATTGTCGGGTTTGGGGCTTTCGGTGGTTCCTTGGTGACTGGGAATTGCTTGTGTGCATGTGTTGGGTGCATGCTTCCGGGT
CTCAGCTGCCCCAGGCCCGCACAGGCAACCCCTTCCCATCCAAAGCCATTGGTGGAGCTTCTCTGGAATCATTTGCCAAAAGCCCAAGGC
AGAATCCAAGGGTCCAAGACCATTTCCATGGAGCTCATGTTTTTCTTTTCTGTAGGAACTTTTTTTTAACCAGCACCCACCATAATTCCG
AAGGCCACGTTTCATCTTTCCTGGATCACTACAGTGAAGTATTACAGTTGTACAGTTCCCAGTCTGGCCTTGGCTTGCTCGGATAAAACT
TTGTATGTATTTTGTATGGCATAGATTCTATATTGTAATGATGTCCTATGCAAAAAGAAAAATTAACGAAATTGTAAATTTTATTGTTTT

>51700_51700_3_MARCH6-KLF13_MARCH6_chr5_10354029_ENST00000503788_KLF13_chr15_31664213_ENST00000307145_length(amino acids)=228AA_BP=
MESTLPASQGRATPSPCLGERWTVSAPKDFGIKFLNLECEFLRHKMYSECGFLCLTRKQLWEGPHFGTGHEDLCTTSTQGSLLSRSLPNI
PLSLPDPMQAGRSESPNTAWQPEGPAPHPTRVEVTLSLPVPTTAETMPLPNLGSIGLPRSHHHAVGQSQLTHSGKKRAPDGILCLSSCCG

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Fusion Gene PPI Analysis for MARCH6-KLF13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MARCH6-KLF13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MARCH6-KLF13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource