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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:MARCH6-ZFAND3 (FusionGDB2 ID:51708)

Fusion Gene Summary for MARCH6-ZFAND3

Fusion gene summary

Fusion gene information	Fusion gene name: MARCH6-ZFAND3
	Fusion gene ID: 51708
		Hgene	Tgene
	Gene symbol	MARCH6	ZFAND3
	Gene ID	10299	60685
	Gene name	membrane associated ring-CH-type finger 6	zinc finger AN1-type containing 3
	Synonyms	DOA10\|FAME3\|MARCH-VI\|MARCH6\|RNF176\|TEB4	TEX27
	Cytomap	5p15.2	6p21.2
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase MARCH6RING finger protein 176RING-type E3 ubiquitin transferase MARCH6doa10 homologmembrane associated ring finger 6membrane-associated RING finger protein 6membrane-associated RING-CH finger protein 6membrane-associated	AN1-type zinc finger protein 3testis expressed sequence 27testis-expressed protein 27zinc finger, AN1-type domain 3
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000274140, ENST00000449913, ENST00000503788, ENST00000510792, ENST00000606497,	ENST00000463847, ENST00000287218, ENST00000373391,
Fusion gene scores	* DoF score	14 X 8 X 8=896	25 X 21 X 12=6300
	# samples	14	26
	** MAII score	log2(14/896*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/6300*10)=-4.59876830024619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MARCH6 [Title/Abstract] AND ZFAND3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MARCH6(10354029)-ZFAND3(38029367), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MARCH6	GO:0010498	proteasomal protein catabolic process	15673284
Hgene	MARCH6	GO:0016567	protein ubiquitination	24449766
Hgene	MARCH6	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	24449766
Hgene	MARCH6	GO:0070936	protein K48-linked ubiquitination	15673284

Fusion gene breakpoints across MARCH6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZFAND3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	DB151625	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+

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Fusion Gene ORF analysis for MARCH6-ZFAND3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000274140	ENST00000463847	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
5CDS-intron	ENST00000449913	ENST00000463847	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
5CDS-intron	ENST00000503788	ENST00000463847	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
In-frame	ENST00000274140	ENST00000287218	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
In-frame	ENST00000274140	ENST00000373391	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
In-frame	ENST00000449913	ENST00000287218	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
In-frame	ENST00000449913	ENST00000373391	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
In-frame	ENST00000503788	ENST00000287218	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
In-frame	ENST00000503788	ENST00000373391	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
intron-3CDS	ENST00000510792	ENST00000287218	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
intron-3CDS	ENST00000510792	ENST00000373391	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
intron-3CDS	ENST00000606497	ENST00000287218	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
intron-3CDS	ENST00000606497	ENST00000373391	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
intron-intron	ENST00000510792	ENST00000463847	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+
intron-intron	ENST00000606497	ENST00000463847	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000449913	MARCH6	chr5	10354029	+	ENST00000287218	ZFAND3	chr6	38029367	+	3022	215	100	786	228
ENST00000449913	MARCH6	chr5	10354029	+	ENST00000373391	ZFAND3	chr6	38029367	+	2956	215	100	720	206
ENST00000503788	MARCH6	chr5	10354029	+	ENST00000287218	ZFAND3	chr6	38029367	+	3009	202	87	773	228
ENST00000503788	MARCH6	chr5	10354029	+	ENST00000373391	ZFAND3	chr6	38029367	+	2943	202	87	707	206
ENST00000274140	MARCH6	chr5	10354029	+	ENST00000287218	ZFAND3	chr6	38029367	+	2958	151	36	722	228
ENST00000274140	MARCH6	chr5	10354029	+	ENST00000373391	ZFAND3	chr6	38029367	+	2892	151	36	656	206

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000449913	ENST00000287218	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+	0.014403691	0.9855963
ENST00000449913	ENST00000373391	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+	0.004645053	0.995355
ENST00000503788	ENST00000287218	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+	0.013776233	0.98622376
ENST00000503788	ENST00000373391	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+	0.004627051	0.99537295
ENST00000274140	ENST00000287218	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+	0.009783927	0.99021614
ENST00000274140	ENST00000373391	MARCH6	chr5	10354029	+	ZFAND3	chr6	38029367	+	0.005201859	0.99479806

Top

Fusion Genomic Features for MARCH6-ZFAND3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MARCH6-ZFAND3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:10354029/chr6:38029367)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ZFAND3

chr5:10354029

chr6:38029367

ENST00000287218

154_200

228.0

Zinc finger

AN1-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

113_142

911.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

164_283

911.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

1_91

911.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

305_336

911.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

358_376

911.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

398_421

911.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

443_480

911.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

502_519

911.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

541_632

911.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

654_678

911.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

700_721

911.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

743_764

911.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

786_815

911.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

837_848

911.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

870_910

911.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

113_142

863.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

164_283

863.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

1_91

863.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

305_336

863.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

358_376

863.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

398_421

863.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

443_480

863.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

502_519

863.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

541_632

863.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

654_678

863.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

700_721

863.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

743_764

863.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

786_815

863.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

837_848

863.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

870_910

863.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

113_142

806.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

164_283

806.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

1_91

806.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

305_336

806.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

358_376

806.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

398_421

806.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

443_480

806.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

502_519

806.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

541_632

806.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

654_678

806.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

700_721

806.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

743_764

806.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

786_815

806.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

837_848

806.0

Topological domain

Extracellular

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

870_910

806.0

Topological domain

Cytoplasmic

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

143_163

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

284_304

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

337_357

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

377_397

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

422_442

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

481_501

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

520_540

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

633_653

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

679_699

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

722_742

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

765_785

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

816_836

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

849_869

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

92_112

911.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

143_163

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

284_304

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

337_357

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

377_397

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

422_442

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

481_501

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

520_540

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

633_653

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

679_699

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

722_742

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

765_785

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

816_836

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

849_869

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

92_112

863.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

143_163

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

284_304

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

337_357

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

377_397

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

422_442

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

481_501

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

520_540

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

633_653

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

679_699

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

722_742

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

765_785

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

816_836

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

849_869

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

92_112

806.0

Transmembrane

Helical

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000274140

1_62

911.0

Zinc finger

RING-CH-type

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000449913

1_62

863.0

Zinc finger

RING-CH-type

Hgene

MARCH6

chr5:10354029

chr6:38029367

ENST00000503788

1_62

806.0

Zinc finger

RING-CH-type

Tgene

ZFAND3

chr5:10354029

chr6:38029367

ENST00000287218

12_44

228.0

Zinc finger

A20-type

Top

Fusion Gene Sequence for MARCH6-ZFAND3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>51708_51708_1_MARCH6-ZFAND3_MARCH6_chr5_10354029_ENST00000274140_ZFAND3_chr6_38029367_ENST00000287218_length(transcript)=2958nt_BP=151nt
CCTCTCGCTTCCTCTCTCGCACCTGAGCGTACGCACCTGCCCGGGCCCGGCTCCCTCCTCCTCTCCCCTCCCTCTTTCCCCGCCCGGCCG
CGGGAGCCTCGTGGCTGCGTCACCGCCGCCCCCCCAGACAAGATGGACACCGCGGAGGAAGATTTTCAAAAGAAACAGCCAGACGATGAT
TCCGCTCCAAGTACAAGTAACAGCCAATCAGATTTGTTTTCCGAAGAGACCACCAGTGACAACAACAATACCTCGATAACCACGCCAACT
CTTAGTCCCAGCCAGCAGCCGCTTCCGACAGAACTGAATGTAACTTCACCGAGTAAAGAGGAGTGTGGGCCATGCACAGACACAGCTCAT
GTCTCATTAATCACACCAACAAAAAGATCCTGTGGTACAGATTCACAGTCTGAGAATGAGGCTTCACCAGTAAAACGGCCACGACTACTT
GAGAATACGGAACGGTCCGAGGAAACCAGTCGATCTAAACAGAAGAGTCGACGTCGGTGCTTCCAGTGCCAAACCAAACTGGAGCTGGTG
CAGCAGGAATTGGGATCGTGTCGCTGCGGTTATGTGTTCTGTATGTTACATCGCCTCCCCGAGCAGCACGACTGCACATTCGACCACATG
GGCCGTGGCCGGGAGGAAGCCATCATGAAAATGGTGAAGCTGGACCGGAAAGTGGGGCGCTCCTGCCAGCGCATCGGGGAGGGGTGCTCC
TGAAGGCCAGGCATGGCCACCACGTGACGCTGTTCTTAGTTCACTAATGTTAGCCTTATTTAGGACAAAGTCAGCCAGACACCTTGTACT
GGGCACGCGTCAGACTGCAGCCAGTCCGTTTCCTTTCTTTAGCCAGCCATCCTGGTACTGTAGTTTAGGGGTTGATGGTGGTTGAAATTG
ATTTCTGGCTGGTTACTAAGGTGCCTGCTAGCCATTGTATAAAATTAAAACATGAAGAATATTTTTTTTTTGAGCATGGCTAGTGGATTT
AAAACAACACATACCTGTCACTGCTGGAGTCAAACTTATAAAAAGCCTTAAGTGGAAAGTGTTCCAGACGGAGACTCTGAGTTAATAGAG
GAGTAGAAGCTGGTGTTAAAGTTCCCACGACGCACATGGCTTTGCCAGAAACTCTGTTTAATGATCGGCCTTTCACCTCTTCACTTATCC
TTAGTCCCAGTAGCCAGGATACCTGATGGCCACGTGTGCCTTGGCCACGGGAGGCTGCTGAGATTGGCCACGTGGCTGGGCTGGGTGGTG
GCCTCACTCTCCCACAGAGCTGGAAATGGGGGGTGGGGGACAGATTCTTACGGAAATTTTTTTACCTGACTTGCTATGAAAAAACTCATC
ACACAAGAAGAGAAACAGTAACCTCACTTTGAAAATTAGCTCCACTCAAGACTAGTCCACGAACGAGACCCGCCTTTTCTACACAGGATC
CAAGGTCACGAGAAGCAGCCAGAGTGCCCCGCCTCCGCCGGCTCTGGTCTGCCATTCGCCAGTGCAGGGATCTGGCACGGACCAGATGTG
GCGAATGGCAGCACAGCGCGGTGGCTGGGTCTGCACACTGGCCTCTGCAGCCAGATTTCTATATTGGGAGTTTTTTAAAAAGACATTTCA
TAGCCAACAAGAATCAGTAGAAGTGCTGGGAGCAGCAGCTGGGGAAGCTGCCGCCCACGGGCTCTGCCCCTTCCAGCTGGAGCCGCCCGT
GCCTCCAGGGGCCAAGAGGATGATGTCGTGGCCTCCATTCTCGTTTCTATGCAGCCCCATAGTCCAAGGACACCCAGTCCACATCTACCA
TATAGCAAGTTTAGTAAGGGAAGGCAGCATACGTCCCAGGGACAGTGGGTTTGGATCTGTCTAGAACAGCGGTTTGTGGCTGTGGCCCAG
CTCCGAGAGTGATATTTGCTCTGGTAGGTGAGGGCCTGAGGGTACATTTCTCCACCTGTGCCCCCTCATGTTCACAGAGGATTTCAGCAG
CTGCAACTGCGCACGCCAGGTGGGGAAGGGTGGGGGTGGGCCTGGTTGCCCCATGTTAGGAAATCACTACCAGTCAGGTGGGGCTGGGGC
TGGGTGGACAGGATCAGGATTCCCTTGAAAGCCCAGGCAGGGTGAGCAGTCCCAGTGGTCCTAGTGCCGCATCAGATCCAGGTGGGTGAG
GGCAGGAGGCCCCTGCGGAGGCAGCGTGGATCTGCCCACACATAGGCTACTGGAATAGTTTAACCCAGCAACTTTCCTTTTTATAAAACA
ACAAATGGTTCAACTCTGTCTGCAAATTAACAGCTGAACACCTGCAACTGCAAATGTTTTTTGATCCGACGTACTGAAATAGGAAGTCAT
GCTCTTCCCACCCTCCACCCACCAGAGTGGAACCCGCTGCAAAATCCCCAGCCTTAATTCTTGCTTCAGGACCCAGACCGGTGTCTTGCT
CTAGGGCAACCCAGGGCAGAGGGGCCAGGTCTGCCCAGCGTTTACCACTGCTGTCAAGCCACAGCCCTTGGCCACCATACGGGCCATCCT
CAGTGAGGCAGCCCCCCATAGGCTTCCGCCAAGCTCTGGTCCCGAAGAGGCTGTGCGAGCCCTTCCCGGCCCTCCCCAGGGCCCCCCGCC
CCCTCCTCTGCCTGCTGCGTGGAGGCAGCCATGGGAAGGAGCCCAGGGGAGCTGGCCTGGGGGAGCGAAGCCCATGTTCGCTTCCTGACT
TAGAGCTGGGGGGGGTGGGGGGTGGGGCTTGTTCCCCTGCAGTATCTGTTCTGTGAAGTTTGTTAAATGTAAGGAAAGCTTAAATTCTTG
TATCTTTAAAAGAGAAAATCTTATTTAACCCTTTTGTGTTCTAGATTTACTTACACACATAGCCTAGAGCTCAGTTTTAGTTTTAACATT

>51708_51708_1_MARCH6-ZFAND3_MARCH6_chr5_10354029_ENST00000274140_ZFAND3_chr6_38029367_ENST00000287218_length(amino acids)=228AA_BP=38
MPGPGSLLLSPPSFPARPREPRGCVTAAPPDKMDTAEEDFQKKQPDDDSAPSTSNSQSDLFSEETTSDNNNTSITTPTLSPSQQPLPTEL
NVTSPSKEECGPCTDTAHVSLITPTKRSCGTDSQSENEASPVKRPRLLENTERSEETSRSKQKSRRRCFQCQTKLELVQQELGSCRCGYV

--------------------------------------------------------------
>51708_51708_2_MARCH6-ZFAND3_MARCH6_chr5_10354029_ENST00000274140_ZFAND3_chr6_38029367_ENST00000373391_length(transcript)=2892nt_BP=151nt
CCTCTCGCTTCCTCTCTCGCACCTGAGCGTACGCACCTGCCCGGGCCCGGCTCCCTCCTCCTCTCCCCTCCCTCTTTCCCCGCCCGGCCG
CGGGAGCCTCGTGGCTGCGTCACCGCCGCCCCCCCAGACAAGATGGACACCGCGGAGGAAGATTTTCAAAAGAAACAGCCAGACGATGAT
TCCGCTCCAAGTACAAGTAACAGCCAATCAGATTTGTTTTCCGAAGAGACCACCAGTGACAACAACAATACCTCGATAACCACGCCAACT
CTTAGTCCCAGCCAGCAGCCGCTTCCGACAGAACTGAATGTAACTTCACCGAGTAAAGAGGAGTATTCACAGTCTGAGAATGAGGCTTCA
CCAGTAAAACGGCCACGACTACTTGAGAATACGGAACGGTCCGAGGAAACCAGTCGATCTAAACAGAAGAGTCGACGTCGGTGCTTCCAG
TGCCAAACCAAACTGGAGCTGGTGCAGCAGGAATTGGGATCGTGTCGCTGCGGTTATGTGTTCTGTATGTTACATCGCCTCCCCGAGCAG
CACGACTGCACATTCGACCACATGGGCCGTGGCCGGGAGGAAGCCATCATGAAAATGGTGAAGCTGGACCGGAAAGTGGGGCGCTCCTGC
CAGCGCATCGGGGAGGGGTGCTCCTGAAGGCCAGGCATGGCCACCACGTGACGCTGTTCTTAGTTCACTAATGTTAGCCTTATTTAGGAC
AAAGTCAGCCAGACACCTTGTACTGGGCACGCGTCAGACTGCAGCCAGTCCGTTTCCTTTCTTTAGCCAGCCATCCTGGTACTGTAGTTT
AGGGGTTGATGGTGGTTGAAATTGATTTCTGGCTGGTTACTAAGGTGCCTGCTAGCCATTGTATAAAATTAAAACATGAAGAATATTTTT
TTTTTGAGCATGGCTAGTGGATTTAAAACAACACATACCTGTCACTGCTGGAGTCAAACTTATAAAAAGCCTTAAGTGGAAAGTGTTCCA
GACGGAGACTCTGAGTTAATAGAGGAGTAGAAGCTGGTGTTAAAGTTCCCACGACGCACATGGCTTTGCCAGAAACTCTGTTTAATGATC
GGCCTTTCACCTCTTCACTTATCCTTAGTCCCAGTAGCCAGGATACCTGATGGCCACGTGTGCCTTGGCCACGGGAGGCTGCTGAGATTG
GCCACGTGGCTGGGCTGGGTGGTGGCCTCACTCTCCCACAGAGCTGGAAATGGGGGGTGGGGGACAGATTCTTACGGAAATTTTTTTACC
TGACTTGCTATGAAAAAACTCATCACACAAGAAGAGAAACAGTAACCTCACTTTGAAAATTAGCTCCACTCAAGACTAGTCCACGAACGA
GACCCGCCTTTTCTACACAGGATCCAAGGTCACGAGAAGCAGCCAGAGTGCCCCGCCTCCGCCGGCTCTGGTCTGCCATTCGCCAGTGCA
GGGATCTGGCACGGACCAGATGTGGCGAATGGCAGCACAGCGCGGTGGCTGGGTCTGCACACTGGCCTCTGCAGCCAGATTTCTATATTG
GGAGTTTTTTAAAAAGACATTTCATAGCCAACAAGAATCAGTAGAAGTGCTGGGAGCAGCAGCTGGGGAAGCTGCCGCCCACGGGCTCTG
CCCCTTCCAGCTGGAGCCGCCCGTGCCTCCAGGGGCCAAGAGGATGATGTCGTGGCCTCCATTCTCGTTTCTATGCAGCCCCATAGTCCA
AGGACACCCAGTCCACATCTACCATATAGCAAGTTTAGTAAGGGAAGGCAGCATACGTCCCAGGGACAGTGGGTTTGGATCTGTCTAGAA
CAGCGGTTTGTGGCTGTGGCCCAGCTCCGAGAGTGATATTTGCTCTGGTAGGTGAGGGCCTGAGGGTACATTTCTCCACCTGTGCCCCCT
CATGTTCACAGAGGATTTCAGCAGCTGCAACTGCGCACGCCAGGTGGGGAAGGGTGGGGGTGGGCCTGGTTGCCCCATGTTAGGAAATCA
CTACCAGTCAGGTGGGGCTGGGGCTGGGTGGACAGGATCAGGATTCCCTTGAAAGCCCAGGCAGGGTGAGCAGTCCCAGTGGTCCTAGTG
CCGCATCAGATCCAGGTGGGTGAGGGCAGGAGGCCCCTGCGGAGGCAGCGTGGATCTGCCCACACATAGGCTACTGGAATAGTTTAACCC
AGCAACTTTCCTTTTTATAAAACAACAAATGGTTCAACTCTGTCTGCAAATTAACAGCTGAACACCTGCAACTGCAAATGTTTTTTGATC
CGACGTACTGAAATAGGAAGTCATGCTCTTCCCACCCTCCACCCACCAGAGTGGAACCCGCTGCAAAATCCCCAGCCTTAATTCTTGCTT
CAGGACCCAGACCGGTGTCTTGCTCTAGGGCAACCCAGGGCAGAGGGGCCAGGTCTGCCCAGCGTTTACCACTGCTGTCAAGCCACAGCC
CTTGGCCACCATACGGGCCATCCTCAGTGAGGCAGCCCCCCATAGGCTTCCGCCAAGCTCTGGTCCCGAAGAGGCTGTGCGAGCCCTTCC
CGGCCCTCCCCAGGGCCCCCCGCCCCCTCCTCTGCCTGCTGCGTGGAGGCAGCCATGGGAAGGAGCCCAGGGGAGCTGGCCTGGGGGAGC
GAAGCCCATGTTCGCTTCCTGACTTAGAGCTGGGGGGGGTGGGGGGTGGGGCTTGTTCCCCTGCAGTATCTGTTCTGTGAAGTTTGTTAA
ATGTAAGGAAAGCTTAAATTCTTGTATCTTTAAAAGAGAAAATCTTATTTAACCCTTTTGTGTTCTAGATTTACTTACACACATAGCCTA
GAGCTCAGTTTTAGTTTTAACATTGTGAAAATATTAAAAGAATCTTGTAACTTTATTCTTTTTTCTCCTGCTGAAAAAAAAAATTAAACC

>51708_51708_2_MARCH6-ZFAND3_MARCH6_chr5_10354029_ENST00000274140_ZFAND3_chr6_38029367_ENST00000373391_length(amino acids)=206AA_BP=38
MPGPGSLLLSPPSFPARPREPRGCVTAAPPDKMDTAEEDFQKKQPDDDSAPSTSNSQSDLFSEETTSDNNNTSITTPTLSPSQQPLPTEL
NVTSPSKEEYSQSENEASPVKRPRLLENTERSEETSRSKQKSRRRCFQCQTKLELVQQELGSCRCGYVFCMLHRLPEQHDCTFDHMGRGR

--------------------------------------------------------------
>51708_51708_3_MARCH6-ZFAND3_MARCH6_chr5_10354029_ENST00000449913_ZFAND3_chr6_38029367_ENST00000287218_length(transcript)=3022nt_BP=215nt
CCCTCCCCCTCCCGTGTCGCTCGCTTTCTGTCAGCCTCTCTCCCTCTCCCTCTCCCCTCTCCTTCCTCTCGCTTCCTCTCTCGCACCTGA
GCGTACGCACCTGCCCGGGCCCGGCTCCCTCCTCCTCTCCCCTCCCTCTTTCCCCGCCCGGCCGCGGGAGCCTCGTGGCTGCGTCACCGC
CGCCCCCCCAGACAAGATGGACACCGCGGAGGAAGATTTTCAAAAGAAACAGCCAGACGATGATTCCGCTCCAAGTACAAGTAACAGCCA
ATCAGATTTGTTTTCCGAAGAGACCACCAGTGACAACAACAATACCTCGATAACCACGCCAACTCTTAGTCCCAGCCAGCAGCCGCTTCC
GACAGAACTGAATGTAACTTCACCGAGTAAAGAGGAGTGTGGGCCATGCACAGACACAGCTCATGTCTCATTAATCACACCAACAAAAAG
ATCCTGTGGTACAGATTCACAGTCTGAGAATGAGGCTTCACCAGTAAAACGGCCACGACTACTTGAGAATACGGAACGGTCCGAGGAAAC
CAGTCGATCTAAACAGAAGAGTCGACGTCGGTGCTTCCAGTGCCAAACCAAACTGGAGCTGGTGCAGCAGGAATTGGGATCGTGTCGCTG
CGGTTATGTGTTCTGTATGTTACATCGCCTCCCCGAGCAGCACGACTGCACATTCGACCACATGGGCCGTGGCCGGGAGGAAGCCATCAT
GAAAATGGTGAAGCTGGACCGGAAAGTGGGGCGCTCCTGCCAGCGCATCGGGGAGGGGTGCTCCTGAAGGCCAGGCATGGCCACCACGTG
ACGCTGTTCTTAGTTCACTAATGTTAGCCTTATTTAGGACAAAGTCAGCCAGACACCTTGTACTGGGCACGCGTCAGACTGCAGCCAGTC
CGTTTCCTTTCTTTAGCCAGCCATCCTGGTACTGTAGTTTAGGGGTTGATGGTGGTTGAAATTGATTTCTGGCTGGTTACTAAGGTGCCT
GCTAGCCATTGTATAAAATTAAAACATGAAGAATATTTTTTTTTTGAGCATGGCTAGTGGATTTAAAACAACACATACCTGTCACTGCTG
GAGTCAAACTTATAAAAAGCCTTAAGTGGAAAGTGTTCCAGACGGAGACTCTGAGTTAATAGAGGAGTAGAAGCTGGTGTTAAAGTTCCC
ACGACGCACATGGCTTTGCCAGAAACTCTGTTTAATGATCGGCCTTTCACCTCTTCACTTATCCTTAGTCCCAGTAGCCAGGATACCTGA
TGGCCACGTGTGCCTTGGCCACGGGAGGCTGCTGAGATTGGCCACGTGGCTGGGCTGGGTGGTGGCCTCACTCTCCCACAGAGCTGGAAA
TGGGGGGTGGGGGACAGATTCTTACGGAAATTTTTTTACCTGACTTGCTATGAAAAAACTCATCACACAAGAAGAGAAACAGTAACCTCA
CTTTGAAAATTAGCTCCACTCAAGACTAGTCCACGAACGAGACCCGCCTTTTCTACACAGGATCCAAGGTCACGAGAAGCAGCCAGAGTG
CCCCGCCTCCGCCGGCTCTGGTCTGCCATTCGCCAGTGCAGGGATCTGGCACGGACCAGATGTGGCGAATGGCAGCACAGCGCGGTGGCT
GGGTCTGCACACTGGCCTCTGCAGCCAGATTTCTATATTGGGAGTTTTTTAAAAAGACATTTCATAGCCAACAAGAATCAGTAGAAGTGC
TGGGAGCAGCAGCTGGGGAAGCTGCCGCCCACGGGCTCTGCCCCTTCCAGCTGGAGCCGCCCGTGCCTCCAGGGGCCAAGAGGATGATGT
CGTGGCCTCCATTCTCGTTTCTATGCAGCCCCATAGTCCAAGGACACCCAGTCCACATCTACCATATAGCAAGTTTAGTAAGGGAAGGCA
GCATACGTCCCAGGGACAGTGGGTTTGGATCTGTCTAGAACAGCGGTTTGTGGCTGTGGCCCAGCTCCGAGAGTGATATTTGCTCTGGTA
GGTGAGGGCCTGAGGGTACATTTCTCCACCTGTGCCCCCTCATGTTCACAGAGGATTTCAGCAGCTGCAACTGCGCACGCCAGGTGGGGA
AGGGTGGGGGTGGGCCTGGTTGCCCCATGTTAGGAAATCACTACCAGTCAGGTGGGGCTGGGGCTGGGTGGACAGGATCAGGATTCCCTT
GAAAGCCCAGGCAGGGTGAGCAGTCCCAGTGGTCCTAGTGCCGCATCAGATCCAGGTGGGTGAGGGCAGGAGGCCCCTGCGGAGGCAGCG
TGGATCTGCCCACACATAGGCTACTGGAATAGTTTAACCCAGCAACTTTCCTTTTTATAAAACAACAAATGGTTCAACTCTGTCTGCAAA
TTAACAGCTGAACACCTGCAACTGCAAATGTTTTTTGATCCGACGTACTGAAATAGGAAGTCATGCTCTTCCCACCCTCCACCCACCAGA
GTGGAACCCGCTGCAAAATCCCCAGCCTTAATTCTTGCTTCAGGACCCAGACCGGTGTCTTGCTCTAGGGCAACCCAGGGCAGAGGGGCC
AGGTCTGCCCAGCGTTTACCACTGCTGTCAAGCCACAGCCCTTGGCCACCATACGGGCCATCCTCAGTGAGGCAGCCCCCCATAGGCTTC
CGCCAAGCTCTGGTCCCGAAGAGGCTGTGCGAGCCCTTCCCGGCCCTCCCCAGGGCCCCCCGCCCCCTCCTCTGCCTGCTGCGTGGAGGC
AGCCATGGGAAGGAGCCCAGGGGAGCTGGCCTGGGGGAGCGAAGCCCATGTTCGCTTCCTGACTTAGAGCTGGGGGGGGTGGGGGGTGGG
GCTTGTTCCCCTGCAGTATCTGTTCTGTGAAGTTTGTTAAATGTAAGGAAAGCTTAAATTCTTGTATCTTTAAAAGAGAAAATCTTATTT
AACCCTTTTGTGTTCTAGATTTACTTACACACATAGCCTAGAGCTCAGTTTTAGTTTTAACATTGTGAAAATATTAAAAGAATCTTGTAA

>51708_51708_3_MARCH6-ZFAND3_MARCH6_chr5_10354029_ENST00000449913_ZFAND3_chr6_38029367_ENST00000287218_length(amino acids)=228AA_BP=38
MPGPGSLLLSPPSFPARPREPRGCVTAAPPDKMDTAEEDFQKKQPDDDSAPSTSNSQSDLFSEETTSDNNNTSITTPTLSPSQQPLPTEL
NVTSPSKEECGPCTDTAHVSLITPTKRSCGTDSQSENEASPVKRPRLLENTERSEETSRSKQKSRRRCFQCQTKLELVQQELGSCRCGYV

--------------------------------------------------------------
>51708_51708_4_MARCH6-ZFAND3_MARCH6_chr5_10354029_ENST00000449913_ZFAND3_chr6_38029367_ENST00000373391_length(transcript)=2956nt_BP=215nt
CCCTCCCCCTCCCGTGTCGCTCGCTTTCTGTCAGCCTCTCTCCCTCTCCCTCTCCCCTCTCCTTCCTCTCGCTTCCTCTCTCGCACCTGA
GCGTACGCACCTGCCCGGGCCCGGCTCCCTCCTCCTCTCCCCTCCCTCTTTCCCCGCCCGGCCGCGGGAGCCTCGTGGCTGCGTCACCGC
CGCCCCCCCAGACAAGATGGACACCGCGGAGGAAGATTTTCAAAAGAAACAGCCAGACGATGATTCCGCTCCAAGTACAAGTAACAGCCA
ATCAGATTTGTTTTCCGAAGAGACCACCAGTGACAACAACAATACCTCGATAACCACGCCAACTCTTAGTCCCAGCCAGCAGCCGCTTCC
GACAGAACTGAATGTAACTTCACCGAGTAAAGAGGAGTATTCACAGTCTGAGAATGAGGCTTCACCAGTAAAACGGCCACGACTACTTGA
GAATACGGAACGGTCCGAGGAAACCAGTCGATCTAAACAGAAGAGTCGACGTCGGTGCTTCCAGTGCCAAACCAAACTGGAGCTGGTGCA
GCAGGAATTGGGATCGTGTCGCTGCGGTTATGTGTTCTGTATGTTACATCGCCTCCCCGAGCAGCACGACTGCACATTCGACCACATGGG
CCGTGGCCGGGAGGAAGCCATCATGAAAATGGTGAAGCTGGACCGGAAAGTGGGGCGCTCCTGCCAGCGCATCGGGGAGGGGTGCTCCTG
AAGGCCAGGCATGGCCACCACGTGACGCTGTTCTTAGTTCACTAATGTTAGCCTTATTTAGGACAAAGTCAGCCAGACACCTTGTACTGG
GCACGCGTCAGACTGCAGCCAGTCCGTTTCCTTTCTTTAGCCAGCCATCCTGGTACTGTAGTTTAGGGGTTGATGGTGGTTGAAATTGAT
TTCTGGCTGGTTACTAAGGTGCCTGCTAGCCATTGTATAAAATTAAAACATGAAGAATATTTTTTTTTTGAGCATGGCTAGTGGATTTAA
AACAACACATACCTGTCACTGCTGGAGTCAAACTTATAAAAAGCCTTAAGTGGAAAGTGTTCCAGACGGAGACTCTGAGTTAATAGAGGA
GTAGAAGCTGGTGTTAAAGTTCCCACGACGCACATGGCTTTGCCAGAAACTCTGTTTAATGATCGGCCTTTCACCTCTTCACTTATCCTT
AGTCCCAGTAGCCAGGATACCTGATGGCCACGTGTGCCTTGGCCACGGGAGGCTGCTGAGATTGGCCACGTGGCTGGGCTGGGTGGTGGC
CTCACTCTCCCACAGAGCTGGAAATGGGGGGTGGGGGACAGATTCTTACGGAAATTTTTTTACCTGACTTGCTATGAAAAAACTCATCAC
ACAAGAAGAGAAACAGTAACCTCACTTTGAAAATTAGCTCCACTCAAGACTAGTCCACGAACGAGACCCGCCTTTTCTACACAGGATCCA
AGGTCACGAGAAGCAGCCAGAGTGCCCCGCCTCCGCCGGCTCTGGTCTGCCATTCGCCAGTGCAGGGATCTGGCACGGACCAGATGTGGC
GAATGGCAGCACAGCGCGGTGGCTGGGTCTGCACACTGGCCTCTGCAGCCAGATTTCTATATTGGGAGTTTTTTAAAAAGACATTTCATA
GCCAACAAGAATCAGTAGAAGTGCTGGGAGCAGCAGCTGGGGAAGCTGCCGCCCACGGGCTCTGCCCCTTCCAGCTGGAGCCGCCCGTGC
CTCCAGGGGCCAAGAGGATGATGTCGTGGCCTCCATTCTCGTTTCTATGCAGCCCCATAGTCCAAGGACACCCAGTCCACATCTACCATA
TAGCAAGTTTAGTAAGGGAAGGCAGCATACGTCCCAGGGACAGTGGGTTTGGATCTGTCTAGAACAGCGGTTTGTGGCTGTGGCCCAGCT
CCGAGAGTGATATTTGCTCTGGTAGGTGAGGGCCTGAGGGTACATTTCTCCACCTGTGCCCCCTCATGTTCACAGAGGATTTCAGCAGCT
GCAACTGCGCACGCCAGGTGGGGAAGGGTGGGGGTGGGCCTGGTTGCCCCATGTTAGGAAATCACTACCAGTCAGGTGGGGCTGGGGCTG
GGTGGACAGGATCAGGATTCCCTTGAAAGCCCAGGCAGGGTGAGCAGTCCCAGTGGTCCTAGTGCCGCATCAGATCCAGGTGGGTGAGGG
CAGGAGGCCCCTGCGGAGGCAGCGTGGATCTGCCCACACATAGGCTACTGGAATAGTTTAACCCAGCAACTTTCCTTTTTATAAAACAAC
AAATGGTTCAACTCTGTCTGCAAATTAACAGCTGAACACCTGCAACTGCAAATGTTTTTTGATCCGACGTACTGAAATAGGAAGTCATGC
TCTTCCCACCCTCCACCCACCAGAGTGGAACCCGCTGCAAAATCCCCAGCCTTAATTCTTGCTTCAGGACCCAGACCGGTGTCTTGCTCT
AGGGCAACCCAGGGCAGAGGGGCCAGGTCTGCCCAGCGTTTACCACTGCTGTCAAGCCACAGCCCTTGGCCACCATACGGGCCATCCTCA
GTGAGGCAGCCCCCCATAGGCTTCCGCCAAGCTCTGGTCCCGAAGAGGCTGTGCGAGCCCTTCCCGGCCCTCCCCAGGGCCCCCCGCCCC
CTCCTCTGCCTGCTGCGTGGAGGCAGCCATGGGAAGGAGCCCAGGGGAGCTGGCCTGGGGGAGCGAAGCCCATGTTCGCTTCCTGACTTA
GAGCTGGGGGGGGTGGGGGGTGGGGCTTGTTCCCCTGCAGTATCTGTTCTGTGAAGTTTGTTAAATGTAAGGAAAGCTTAAATTCTTGTA
TCTTTAAAAGAGAAAATCTTATTTAACCCTTTTGTGTTCTAGATTTACTTACACACATAGCCTAGAGCTCAGTTTTAGTTTTAACATTGT

>51708_51708_4_MARCH6-ZFAND3_MARCH6_chr5_10354029_ENST00000449913_ZFAND3_chr6_38029367_ENST00000373391_length(amino acids)=206AA_BP=38
MPGPGSLLLSPPSFPARPREPRGCVTAAPPDKMDTAEEDFQKKQPDDDSAPSTSNSQSDLFSEETTSDNNNTSITTPTLSPSQQPLPTEL
NVTSPSKEEYSQSENEASPVKRPRLLENTERSEETSRSKQKSRRRCFQCQTKLELVQQELGSCRCGYVFCMLHRLPEQHDCTFDHMGRGR

--------------------------------------------------------------
>51708_51708_5_MARCH6-ZFAND3_MARCH6_chr5_10354029_ENST00000503788_ZFAND3_chr6_38029367_ENST00000287218_length(transcript)=3009nt_BP=202nt
GTGTCGCTCGCTTTCTGTCAGCCTCTCTCCCTCTCCCTCTCCCCTCTCCTTCCTCTCGCTTCCTCTCTCGCACCTGAGCGTACGCACCTG
CCCGGGCCCGGCTCCCTCCTCCTCTCCCCTCCCTCTTTCCCCGCCCGGCCGCGGGAGCCTCGTGGCTGCGTCACCGCCGCCCCCCCAGAC
AAGATGGACACCGCGGAGGAAGATTTTCAAAAGAAACAGCCAGACGATGATTCCGCTCCAAGTACAAGTAACAGCCAATCAGATTTGTTT
TCCGAAGAGACCACCAGTGACAACAACAATACCTCGATAACCACGCCAACTCTTAGTCCCAGCCAGCAGCCGCTTCCGACAGAACTGAAT
GTAACTTCACCGAGTAAAGAGGAGTGTGGGCCATGCACAGACACAGCTCATGTCTCATTAATCACACCAACAAAAAGATCCTGTGGTACA
GATTCACAGTCTGAGAATGAGGCTTCACCAGTAAAACGGCCACGACTACTTGAGAATACGGAACGGTCCGAGGAAACCAGTCGATCTAAA
CAGAAGAGTCGACGTCGGTGCTTCCAGTGCCAAACCAAACTGGAGCTGGTGCAGCAGGAATTGGGATCGTGTCGCTGCGGTTATGTGTTC
TGTATGTTACATCGCCTCCCCGAGCAGCACGACTGCACATTCGACCACATGGGCCGTGGCCGGGAGGAAGCCATCATGAAAATGGTGAAG
CTGGACCGGAAAGTGGGGCGCTCCTGCCAGCGCATCGGGGAGGGGTGCTCCTGAAGGCCAGGCATGGCCACCACGTGACGCTGTTCTTAG
TTCACTAATGTTAGCCTTATTTAGGACAAAGTCAGCCAGACACCTTGTACTGGGCACGCGTCAGACTGCAGCCAGTCCGTTTCCTTTCTT
TAGCCAGCCATCCTGGTACTGTAGTTTAGGGGTTGATGGTGGTTGAAATTGATTTCTGGCTGGTTACTAAGGTGCCTGCTAGCCATTGTA
TAAAATTAAAACATGAAGAATATTTTTTTTTTGAGCATGGCTAGTGGATTTAAAACAACACATACCTGTCACTGCTGGAGTCAAACTTAT
AAAAAGCCTTAAGTGGAAAGTGTTCCAGACGGAGACTCTGAGTTAATAGAGGAGTAGAAGCTGGTGTTAAAGTTCCCACGACGCACATGG
CTTTGCCAGAAACTCTGTTTAATGATCGGCCTTTCACCTCTTCACTTATCCTTAGTCCCAGTAGCCAGGATACCTGATGGCCACGTGTGC
CTTGGCCACGGGAGGCTGCTGAGATTGGCCACGTGGCTGGGCTGGGTGGTGGCCTCACTCTCCCACAGAGCTGGAAATGGGGGGTGGGGG
ACAGATTCTTACGGAAATTTTTTTACCTGACTTGCTATGAAAAAACTCATCACACAAGAAGAGAAACAGTAACCTCACTTTGAAAATTAG
CTCCACTCAAGACTAGTCCACGAACGAGACCCGCCTTTTCTACACAGGATCCAAGGTCACGAGAAGCAGCCAGAGTGCCCCGCCTCCGCC
GGCTCTGGTCTGCCATTCGCCAGTGCAGGGATCTGGCACGGACCAGATGTGGCGAATGGCAGCACAGCGCGGTGGCTGGGTCTGCACACT
GGCCTCTGCAGCCAGATTTCTATATTGGGAGTTTTTTAAAAAGACATTTCATAGCCAACAAGAATCAGTAGAAGTGCTGGGAGCAGCAGC
TGGGGAAGCTGCCGCCCACGGGCTCTGCCCCTTCCAGCTGGAGCCGCCCGTGCCTCCAGGGGCCAAGAGGATGATGTCGTGGCCTCCATT
CTCGTTTCTATGCAGCCCCATAGTCCAAGGACACCCAGTCCACATCTACCATATAGCAAGTTTAGTAAGGGAAGGCAGCATACGTCCCAG
GGACAGTGGGTTTGGATCTGTCTAGAACAGCGGTTTGTGGCTGTGGCCCAGCTCCGAGAGTGATATTTGCTCTGGTAGGTGAGGGCCTGA
GGGTACATTTCTCCACCTGTGCCCCCTCATGTTCACAGAGGATTTCAGCAGCTGCAACTGCGCACGCCAGGTGGGGAAGGGTGGGGGTGG
GCCTGGTTGCCCCATGTTAGGAAATCACTACCAGTCAGGTGGGGCTGGGGCTGGGTGGACAGGATCAGGATTCCCTTGAAAGCCCAGGCA
GGGTGAGCAGTCCCAGTGGTCCTAGTGCCGCATCAGATCCAGGTGGGTGAGGGCAGGAGGCCCCTGCGGAGGCAGCGTGGATCTGCCCAC
ACATAGGCTACTGGAATAGTTTAACCCAGCAACTTTCCTTTTTATAAAACAACAAATGGTTCAACTCTGTCTGCAAATTAACAGCTGAAC
ACCTGCAACTGCAAATGTTTTTTGATCCGACGTACTGAAATAGGAAGTCATGCTCTTCCCACCCTCCACCCACCAGAGTGGAACCCGCTG
CAAAATCCCCAGCCTTAATTCTTGCTTCAGGACCCAGACCGGTGTCTTGCTCTAGGGCAACCCAGGGCAGAGGGGCCAGGTCTGCCCAGC
GTTTACCACTGCTGTCAAGCCACAGCCCTTGGCCACCATACGGGCCATCCTCAGTGAGGCAGCCCCCCATAGGCTTCCGCCAAGCTCTGG
TCCCGAAGAGGCTGTGCGAGCCCTTCCCGGCCCTCCCCAGGGCCCCCCGCCCCCTCCTCTGCCTGCTGCGTGGAGGCAGCCATGGGAAGG
AGCCCAGGGGAGCTGGCCTGGGGGAGCGAAGCCCATGTTCGCTTCCTGACTTAGAGCTGGGGGGGGTGGGGGGTGGGGCTTGTTCCCCTG
CAGTATCTGTTCTGTGAAGTTTGTTAAATGTAAGGAAAGCTTAAATTCTTGTATCTTTAAAAGAGAAAATCTTATTTAACCCTTTTGTGT
TCTAGATTTACTTACACACATAGCCTAGAGCTCAGTTTTAGTTTTAACATTGTGAAAATATTAAAAGAATCTTGTAACTTTATTCTTTTT

>51708_51708_5_MARCH6-ZFAND3_MARCH6_chr5_10354029_ENST00000503788_ZFAND3_chr6_38029367_ENST00000287218_length(amino acids)=228AA_BP=38
MPGPGSLLLSPPSFPARPREPRGCVTAAPPDKMDTAEEDFQKKQPDDDSAPSTSNSQSDLFSEETTSDNNNTSITTPTLSPSQQPLPTEL
NVTSPSKEECGPCTDTAHVSLITPTKRSCGTDSQSENEASPVKRPRLLENTERSEETSRSKQKSRRRCFQCQTKLELVQQELGSCRCGYV

--------------------------------------------------------------
>51708_51708_6_MARCH6-ZFAND3_MARCH6_chr5_10354029_ENST00000503788_ZFAND3_chr6_38029367_ENST00000373391_length(transcript)=2943nt_BP=202nt
GTGTCGCTCGCTTTCTGTCAGCCTCTCTCCCTCTCCCTCTCCCCTCTCCTTCCTCTCGCTTCCTCTCTCGCACCTGAGCGTACGCACCTG
CCCGGGCCCGGCTCCCTCCTCCTCTCCCCTCCCTCTTTCCCCGCCCGGCCGCGGGAGCCTCGTGGCTGCGTCACCGCCGCCCCCCCAGAC
AAGATGGACACCGCGGAGGAAGATTTTCAAAAGAAACAGCCAGACGATGATTCCGCTCCAAGTACAAGTAACAGCCAATCAGATTTGTTT
TCCGAAGAGACCACCAGTGACAACAACAATACCTCGATAACCACGCCAACTCTTAGTCCCAGCCAGCAGCCGCTTCCGACAGAACTGAAT
GTAACTTCACCGAGTAAAGAGGAGTATTCACAGTCTGAGAATGAGGCTTCACCAGTAAAACGGCCACGACTACTTGAGAATACGGAACGG
TCCGAGGAAACCAGTCGATCTAAACAGAAGAGTCGACGTCGGTGCTTCCAGTGCCAAACCAAACTGGAGCTGGTGCAGCAGGAATTGGGA
TCGTGTCGCTGCGGTTATGTGTTCTGTATGTTACATCGCCTCCCCGAGCAGCACGACTGCACATTCGACCACATGGGCCGTGGCCGGGAG
GAAGCCATCATGAAAATGGTGAAGCTGGACCGGAAAGTGGGGCGCTCCTGCCAGCGCATCGGGGAGGGGTGCTCCTGAAGGCCAGGCATG
GCCACCACGTGACGCTGTTCTTAGTTCACTAATGTTAGCCTTATTTAGGACAAAGTCAGCCAGACACCTTGTACTGGGCACGCGTCAGAC
TGCAGCCAGTCCGTTTCCTTTCTTTAGCCAGCCATCCTGGTACTGTAGTTTAGGGGTTGATGGTGGTTGAAATTGATTTCTGGCTGGTTA
CTAAGGTGCCTGCTAGCCATTGTATAAAATTAAAACATGAAGAATATTTTTTTTTTGAGCATGGCTAGTGGATTTAAAACAACACATACC
TGTCACTGCTGGAGTCAAACTTATAAAAAGCCTTAAGTGGAAAGTGTTCCAGACGGAGACTCTGAGTTAATAGAGGAGTAGAAGCTGGTG
TTAAAGTTCCCACGACGCACATGGCTTTGCCAGAAACTCTGTTTAATGATCGGCCTTTCACCTCTTCACTTATCCTTAGTCCCAGTAGCC
AGGATACCTGATGGCCACGTGTGCCTTGGCCACGGGAGGCTGCTGAGATTGGCCACGTGGCTGGGCTGGGTGGTGGCCTCACTCTCCCAC
AGAGCTGGAAATGGGGGGTGGGGGACAGATTCTTACGGAAATTTTTTTACCTGACTTGCTATGAAAAAACTCATCACACAAGAAGAGAAA
CAGTAACCTCACTTTGAAAATTAGCTCCACTCAAGACTAGTCCACGAACGAGACCCGCCTTTTCTACACAGGATCCAAGGTCACGAGAAG
CAGCCAGAGTGCCCCGCCTCCGCCGGCTCTGGTCTGCCATTCGCCAGTGCAGGGATCTGGCACGGACCAGATGTGGCGAATGGCAGCACA
GCGCGGTGGCTGGGTCTGCACACTGGCCTCTGCAGCCAGATTTCTATATTGGGAGTTTTTTAAAAAGACATTTCATAGCCAACAAGAATC
AGTAGAAGTGCTGGGAGCAGCAGCTGGGGAAGCTGCCGCCCACGGGCTCTGCCCCTTCCAGCTGGAGCCGCCCGTGCCTCCAGGGGCCAA
GAGGATGATGTCGTGGCCTCCATTCTCGTTTCTATGCAGCCCCATAGTCCAAGGACACCCAGTCCACATCTACCATATAGCAAGTTTAGT
AAGGGAAGGCAGCATACGTCCCAGGGACAGTGGGTTTGGATCTGTCTAGAACAGCGGTTTGTGGCTGTGGCCCAGCTCCGAGAGTGATAT
TTGCTCTGGTAGGTGAGGGCCTGAGGGTACATTTCTCCACCTGTGCCCCCTCATGTTCACAGAGGATTTCAGCAGCTGCAACTGCGCACG
CCAGGTGGGGAAGGGTGGGGGTGGGCCTGGTTGCCCCATGTTAGGAAATCACTACCAGTCAGGTGGGGCTGGGGCTGGGTGGACAGGATC
AGGATTCCCTTGAAAGCCCAGGCAGGGTGAGCAGTCCCAGTGGTCCTAGTGCCGCATCAGATCCAGGTGGGTGAGGGCAGGAGGCCCCTG
CGGAGGCAGCGTGGATCTGCCCACACATAGGCTACTGGAATAGTTTAACCCAGCAACTTTCCTTTTTATAAAACAACAAATGGTTCAACT
CTGTCTGCAAATTAACAGCTGAACACCTGCAACTGCAAATGTTTTTTGATCCGACGTACTGAAATAGGAAGTCATGCTCTTCCCACCCTC
CACCCACCAGAGTGGAACCCGCTGCAAAATCCCCAGCCTTAATTCTTGCTTCAGGACCCAGACCGGTGTCTTGCTCTAGGGCAACCCAGG
GCAGAGGGGCCAGGTCTGCCCAGCGTTTACCACTGCTGTCAAGCCACAGCCCTTGGCCACCATACGGGCCATCCTCAGTGAGGCAGCCCC
CCATAGGCTTCCGCCAAGCTCTGGTCCCGAAGAGGCTGTGCGAGCCCTTCCCGGCCCTCCCCAGGGCCCCCCGCCCCCTCCTCTGCCTGC
TGCGTGGAGGCAGCCATGGGAAGGAGCCCAGGGGAGCTGGCCTGGGGGAGCGAAGCCCATGTTCGCTTCCTGACTTAGAGCTGGGGGGGG
TGGGGGGTGGGGCTTGTTCCCCTGCAGTATCTGTTCTGTGAAGTTTGTTAAATGTAAGGAAAGCTTAAATTCTTGTATCTTTAAAAGAGA
AAATCTTATTTAACCCTTTTGTGTTCTAGATTTACTTACACACATAGCCTAGAGCTCAGTTTTAGTTTTAACATTGTGAAAATATTAAAA

>51708_51708_6_MARCH6-ZFAND3_MARCH6_chr5_10354029_ENST00000503788_ZFAND3_chr6_38029367_ENST00000373391_length(amino acids)=206AA_BP=38
MPGPGSLLLSPPSFPARPREPRGCVTAAPPDKMDTAEEDFQKKQPDDDSAPSTSNSQSDLFSEETTSDNNNTSITTPTLSPSQQPLPTEL
NVTSPSKEEYSQSENEASPVKRPRLLENTERSEETSRSKQKSRRRCFQCQTKLELVQQELGSCRCGYVFCMLHRLPEQHDCTFDHMGRGR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MARCH6-ZFAND3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MARCH6-ZFAND3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MARCH6-ZFAND3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source