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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MARCH7-SEC24A (FusionGDB2 ID:51709)

Fusion Gene Summary for MARCH7-SEC24A

check button Fusion gene summary
Fusion gene informationFusion gene name: MARCH7-SEC24A
Fusion gene ID: 51709
HgeneTgene
Gene symbol

MARCH7

SEC24A

Gene ID

64844

10802

Gene namemembrane associated ring-CH-type finger 7SEC24 homolog A, COPII coat complex component
SynonymsAXO|AXOT|MARCH-VII|MARCH7|RNF177-
Cytomap

2q24.2

5q31.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MARCH7RING finger protein 177RING-type E3 ubiquitin transferase MARCH7axotrophinmembrane associated ring finger 7membrane-associated RING finger protein 7membrane-associated RING-CH protein VIImembrane-associated ring fiprotein transport protein Sec24ASEC24 family, member ASEC24 related gene family, member ASEC24-related protein A
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000473749, ENST00000259050, 
ENST00000409175, ENST00000409591, 
ENST00000539065, 		ENST00000322887, 
ENST00000398844, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 7 X 4=168
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MARCH7 [Title/Abstract] AND SEC24A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMARCH7(160599764)-SEC24A(134028292), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMARCH7

GO:0006513

protein monoubiquitination

24905733

TgeneSEC24A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check buttonFusion gene breakpoints across MARCH7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SEC24A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4HB-01AMARCH7chr2

160599764

+SEC24Achr5

134028292

+


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Fusion Gene ORF analysis for MARCH7-SEC24A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000473749ENST00000322887MARCH7chr2

160599764

+SEC24Achr5

134028292

+
3UTR-3CDSENST00000473749ENST00000398844MARCH7chr2

160599764

+SEC24Achr5

134028292

+
In-frameENST00000259050ENST00000322887MARCH7chr2

160599764

+SEC24Achr5

134028292

+
In-frameENST00000259050ENST00000398844MARCH7chr2

160599764

+SEC24Achr5

134028292

+
In-frameENST00000409175ENST00000322887MARCH7chr2

160599764

+SEC24Achr5

134028292

+
In-frameENST00000409175ENST00000398844MARCH7chr2

160599764

+SEC24Achr5

134028292

+
In-frameENST00000409591ENST00000322887MARCH7chr2

160599764

+SEC24Achr5

134028292

+
In-frameENST00000409591ENST00000398844MARCH7chr2

160599764

+SEC24Achr5

134028292

+
In-frameENST00000539065ENST00000322887MARCH7chr2

160599764

+SEC24Achr5

134028292

+
In-frameENST00000539065ENST00000398844MARCH7chr2

160599764

+SEC24Achr5

134028292

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409175MARCH7chr2160599764+ENST00000398844SEC24Achr5134028292+48946061642164666
ENST00000409175MARCH7chr2160599764+ENST00000322887SEC24Achr5134028292+1330606164724186
ENST00000539065MARCH7chr2160599764+ENST00000398844SEC24Achr5134028292+47664781322036634
ENST00000539065MARCH7chr2160599764+ENST00000322887SEC24Achr5134028292+1202478132596154
ENST00000259050MARCH7chr2160599764+ENST00000398844SEC24Achr5134028292+47564681222026634
ENST00000259050MARCH7chr2160599764+ENST00000322887SEC24Achr5134028292+1192468122586154
ENST00000409591MARCH7chr2160599764+ENST00000398844SEC24Achr5134028292+4599311791869596
ENST00000409591MARCH7chr2160599764+ENST00000322887SEC24Achr5134028292+103531179429116

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409175ENST00000398844MARCH7chr2160599764+SEC24Achr5134028292+0.0003343380.9996656
ENST00000409175ENST00000322887MARCH7chr2160599764+SEC24Achr5134028292+0.0071696180.99283046
ENST00000539065ENST00000398844MARCH7chr2160599764+SEC24Achr5134028292+0.0003074690.99969256
ENST00000539065ENST00000322887MARCH7chr2160599764+SEC24Achr5134028292+0.0080585190.99194145
ENST00000259050ENST00000398844MARCH7chr2160599764+SEC24Achr5134028292+0.0003103250.9996897
ENST00000259050ENST00000322887MARCH7chr2160599764+SEC24Achr5134028292+0.007445990.992554
ENST00000409591ENST00000398844MARCH7chr2160599764+SEC24Achr5134028292+0.0006295890.9993704
ENST00000409591ENST00000322887MARCH7chr2160599764+SEC24Achr5134028292+0.0757561250.9242439

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Fusion Genomic Features for MARCH7-SEC24A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MARCH7-SEC24A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:160599764/chr5:134028292)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSEC24Achr2:160599764chr5:134028292ENST000003228871013966_1038574614.0RepeatGelsolin-like
TgeneSEC24Achr2:160599764chr5:134028292ENST000003988441023966_10385741094.0RepeatGelsolin-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMARCH7chr2:160599764chr5:134028292ENST00000259050+31013_421115705.0Compositional biasNote=Ser-rich
HgeneMARCH7chr2:160599764chr5:134028292ENST00000409175+51213_421115705.0Compositional biasNote=Ser-rich
HgeneMARCH7chr2:160599764chr5:134028292ENST00000259050+310544_614115705.0Zinc fingerRING-CH-type
HgeneMARCH7chr2:160599764chr5:134028292ENST00000409175+512544_614115705.0Zinc fingerRING-CH-type
TgeneSEC24Achr2:160599764chr5:134028292ENST00000322887101389_237574614.0Compositional biasNote=Pro-rich
TgeneSEC24Achr2:160599764chr5:134028292ENST00000398844102389_2375741094.0Compositional biasNote=Pro-rich
TgeneSEC24Achr2:160599764chr5:134028292ENST000003228871013431_455574614.0RegionNote=Zinc finger-like
TgeneSEC24Achr2:160599764chr5:134028292ENST000003988441023431_4555741094.0RegionNote=Zinc finger-like


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Fusion Gene Sequence for MARCH7-SEC24A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51709_51709_1_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000259050_SEC24A_chr5_134028292_ENST00000322887_length(transcript)=1192nt_BP=468nt
GGTGGCTGGTTCTGCGCCGGATCCGGGAGAGGGGCGGGCGCCATTGTGCTTCGCTGCCGACTGCATTTCCTCAGTCACGGGCCTAGAACT
CCAAGGAGAAAGGCGGCGAAAAATCTTTAAGAATGGAGTCTAAACCTTCAAGGATTCCAAGAAGAATTTCTGTTCAACCTTCCAGCTCCT
TAAGTGCTAGGATGATGTCTGGAAGCAGAGGAAGTAGTTTAAATGATACCTATCACTCAAGAGACTCTTCATTTAGATTGGATTCTGAAT
ATCAGTCTACATCAGCATCAGCATCTGCGTCACCATTTCAATCTGCATGGTATAGTGAATCTGAGATAACTCAGGGAGCACGCTCAAGAT
CGCAGAACCAGCAACGGGATCATGATTCAAAAAGACCTAAACTTTCCTGTACAAACTGTACTACCTCAGCTGGGAGAAATGTTGGAAATG
GTTTAAACACATTATCAGATGTTTTTATACCTATGCCAGAGAACTTATTAGTAAACTTAAATGAAAGTAAAGAGAGTGTCATTGGGGTCA
GTTCAGAAGAAACTCTTATTACCTGCCTGGAAATTGCCATGAGATAATACAGTGAGAGGTGAACAGAATGTGTCTGAAGGGGGGATGTTG
TCTACCCTGTACATGCATATATGCCGTAGGGGTAACATTTTAACTAGCAAGTCTATGGTCTCTGCTGTTGGCAATGGTGACTGTGCCATA
GTGCGAAGTATTTTTTTCCCCATTAACTCTATTTGTACAACCTAACCTGTAAAGGTAGTTGTTTTTCTTTTGTAGTGATATTACTAGTTG
GCAAAGTTACTGGATATCTTAGATTTGCAACAGGGAAGAGCTAAACTCGCTTTGGAACTTACAAGAATAAAGTATGTAGAGGTGATGGAG
AAGGCCATATTTCATGGCATTAAAATACATCAAATCTCTAAACTGTGATGGTTCTTTTGGATACATTTTGGACTTATAGTCTTGCTGGAC
TACTGCATGTGCAAGAACTGTAAGGCCCAACTTTGATTTGTCTTGCTTGCCAATTTATAATGTTGACTTAAAATGGCTTTCTTGTCATTT
GACCAACTTCATTGTTTAGTGTCTGTAGATTCTCTGACCATCATCATGACTCAATGTCTTGTCTATTGTATGAGATACTGACTTAATGTG

>51709_51709_1_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000259050_SEC24A_chr5_134028292_ENST00000322887_length(amino acids)=154AA_BP=113
MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASASPFQSAWYSESEITQGARSRSQNQQRDHDSK

--------------------------------------------------------------
>51709_51709_2_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000259050_SEC24A_chr5_134028292_ENST00000398844_length(transcript)=4756nt_BP=468nt
GGTGGCTGGTTCTGCGCCGGATCCGGGAGAGGGGCGGGCGCCATTGTGCTTCGCTGCCGACTGCATTTCCTCAGTCACGGGCCTAGAACT
CCAAGGAGAAAGGCGGCGAAAAATCTTTAAGAATGGAGTCTAAACCTTCAAGGATTCCAAGAAGAATTTCTGTTCAACCTTCCAGCTCCT
TAAGTGCTAGGATGATGTCTGGAAGCAGAGGAAGTAGTTTAAATGATACCTATCACTCAAGAGACTCTTCATTTAGATTGGATTCTGAAT
ATCAGTCTACATCAGCATCAGCATCTGCGTCACCATTTCAATCTGCATGGTATAGTGAATCTGAGATAACTCAGGGAGCACGCTCAAGAT
CGCAGAACCAGCAACGGGATCATGATTCAAAAAGACCTAAACTTTCCTGTACAAACTGTACTACCTCAGCTGGGAGAAATGTTGGAAATG
GTTTAAACACATTATCAGATGTTTTTATACCTATGCCAGAGAACTTATTAGTAAACTTAAATGAAAGTAAAGAGCTCGTGCAAGATTTAC
TGAAAACTTTGCCACAAATGTTTACCAAGACTCTGGAGACCCAGAGTGCCTTGGGTCCTGCACTGCAGGCTGCCTTTAAGCTGATGTCTC
CAACTGGTGGTCGAATGTCTGTCTTTCAAACACAACTCCCAACTCTTGGAGTGGGAGCCCTGAAACCACGAGAGGAACCAAACCACAGGT
CATCTGCTAAGGATATACACATGACACCATCCACTGACTTCTATAAGAAATTAGCCTTGGACTGTTCTGGTCAGCAAGTTGCTGTTGACT
TATTCCTTCTCAGTGGACAGTATTCTGATTTGGCTTCTCTGGGTTGTATTTCTCGGTATTCAGCAGGTAGTGTCTATTACTATCCCTCTT
ACCATCATCAGCACAACCCAGTCCAAGTACAGAAATTACAGAAGGAACTACAGAGATACCTTACTCGGAAGATTGGCTTTGAGGCAGTCA
TGAGGATTCGGTGCACCAAAGGTCTTTCCATTCATACTTTCCATGGAAACTTCTTTGTTAGGTCAACCGACTTACTGTCTTTGCCTAACG
TCAACCCAGACGCTGGGTATGCAGTACAGATGTCAGTGGAAGAGAGTCTTACTGACACTCAGTTGGTTTCTTTTCAGTCAGCACTCTTGT
ATACATCCAGCAAAGGCGAAAGAAGAATTCGTGTTCATACTTTGTGTTTGCCAGTAGTTTCGACTCTGAATGATGTCTTTCTTGGAGCTG
ATGTTCAAGCAATTTCAGGGTTATTGGCCAATATGGCTGTTGACAGATCTATGACTGCCAGTCTGAGTGACGCTCGGGATGCTCTAGTGA
ATGCAGTCATTGACTCCCTTTCAGCTTACCGTTCTTCAGTCTTAAGTAACCAGCAGCCTGGACTCATGGTTCCTTTTTCTTTGCGGCTTT
TCCCACTTTTTGTGTTGGCTCTCCTTAAACAGAAATCATTCCAGACTGGGACAAATGCACGTCTAGATGAACGCATTTTTGCTATGTGTC
AAGTGAAAAACCAGCCCTTGGTTTACCTTATGCTCACAACTCATCCCAGTTTGTATAGAGTTGACAATCTCTCAGATGAGGGAGCACTCA
ACATCAGTGATAGAACCATACCTCAGCCCCCCATTCTTCAGCTTTCAGTGGAGAAGCTGAGCAGAGATGGAGCTTTCCTCATGGATGCAG
GCTCTGTACTGATGCTTTGGGTTGGAAAAAATTGTACACAGAATTTTCTCAGCCAAGTTCTAGGAGTTCAAAACTATGCATCAATTCCAC
AGCCTATGACAGACCTTCCAGAACTTGATACACCAGAATCTGCCAGAATAATAGCTTTCATCTCTTGGCTTAGAGAGCAGAGACCATTTT
TCCCAATACTTTATGTAATAAGGGATGAGAGTCCAATGAAAGCAAACTTCCTTCAAAACATGATAGAAGACAGAACAGAATCTGCATTAT
CATATTATGAATTCCTGTTGCATATACAGCAACAAGTGAATAAATGAATGAATGAAGAAATTTGACTTATTTTTAAGGAATGTCACGATA
GTGCAGAATACCTGGAAATGTGTAATACCTTCTTTTTCTATTATGTTTGTGGACTAATGTGATGATTGAGATGTTCTCACTGTGATTTCA
ACAACCTATAGCAAATAAAAGACCACAGCAGAGAATCAAACATGCAACTCTGAAATACTGTATTTTTCAAATCAGAATATAGCTACGTAT
GATTGGATACTTTTTTCTTGCCAATTATGTTTGAGTTGTTATGGATTAAAATAAGAATATTGCAGAGGCAAAGTACATTTTGTAAAATAA
AGATTTCTGTGTTCTACATGTATATTTCTCATTTTTAATTTTTCTGAATCTTTGGCTGCTACATTTAAAACCTCACAAACCTAAGTGTTG
CAGGGAAGTTACAAATTGATTGGTAGTGATGTTTTTAAAATAAAAACAATGGAAAGTAAATATAATGTAGGAAAACTAGAATTCATTCCC
CACACGTGTCTTTTTTTTTTCTTTGTTAAGGGAAAGGATCATGTTGACTAAAACTAAACTAATTCTAGTATAGCTTGAGAAAAATATGAA
GAAACACATTCAAGCTTTAAAATCTGTCAGTATTCTTTATGCTTGAAGAACAAAGTCACTTTGATTTGAAGTGAGAACTATCATTAGGTG
GTTTTCTGATTTCCTGATGAAGAGTTGGACATACTGTCTTAATCTATAGTGAAAAGAATTTGAGCTGTCTTCATAAACACTGGGACTAGC
AATGATAATAGGGAGATAAGAAACTTTAATTATCTTGATCCTTTAAGTGGATTTTATTTGGTGCATTTCTGCTCTGGGTATATAATAAAA
GTGGGGGTTTTTGGTGAAATGAGTGAAGAAATGAAAGGTTTCTAAAGTGCTATCCAAATACATCAGTAACATTTTTCTAAGGAGTTTAAT
TGTTAAATTGGAAGTCATTCATAAGAAATATTTATGCTTGAATATGAAAATCTATGAAAGCATAAATGCTGCTGTTTGATTTGGTGGATA
TTAAGATTATACACATCCAACATATTAAAGTTATGAAAGAAACTTGACTTCTGAAAATCCTTAAGAGACTGCTTTCTTGATTCAGCTAGA
GAAATATTATAGTCAAAACTATTGAGTGAATTTTGTTTACAAATAGGTAAATTATACATTTGTATATTTAAAGTGCTGTGACATAGTATC
TTTAAGAGTTTGGCTCAGTTTTCACAGATTCATTTTGTCTTAAGAATTTCTTAAATATGTTCATGTATAATACTTGATCAAAATATTTTT
GGGTTTTTTGTTTTGTTTTAATGGGTTAGAAAATGTTTACAATCTTGGTCTTATATGATCACCAATGGAATAGTAACTTCCAGGTTTATA
TCAATATGAGCTGACTTTAACTGAGTTGTTTGGGATAGGGAAGAAGCAGTCCCTCTACAGTATACAACTACTGCTTGCCAGCTGGATCAA
AATAATCATGTTTTATGAAAATATCTCCCTTAAGCAGTGTTAAGGTTGGTTTGCAGTGTGTAAGTGGCACATTGAACTGGAAGTTTTCTT
GAAAGCTGCTTCATCTATTAAGAAGCAATTTTCAAATTGTAGCGAATTATATTATCCCCTCTTTTAAAGAAACAGTCGTTATATGCTGAT
GTTTCTTAAAATAACTAAAATGTTCCTCTTAATGTGATTTTAAATGGAGTTATTTGTAGGTCCTTTCTTAGTAGTAAAGAATCTTCTAGA
GGGAAACATTTGTGCTTTTAGGGATAATCTTCCTTGTGCCTCACTACATCCCTAAGTGGGTATGACTCTTGTTATTACCACATGCTTTTT
TAGTATATTTCACAAATTTACTTTTAAATATTATTTTAGATACGGTGTAACATGTGCAATTCAGAATAATTTTATAACAGGTCATGAAAA
ACATAACTTTAGTTAGGATTCACAATATTTGTTCTCCACATAATGAGAGAATGAATGAGCCTTTGGAGATACTGATATAAGGCAATTATT
TTTTGCAATGTTGAATGTGTTTTTTAGTTTGATTCTTTTTTTTTCCCCCAATAGGGCACTACCTGCCATATCATCTTGTATTACTTTTTG
ATGTAAAGCGACTAATATTTACACTATGCCATATTTTTTTTAATTATAGTTGTAAATTATGAAAGATCCTTGAATTTTCTACAGATCTAC
AACTACTAATGTAACAGACAAGGGCAATCTTGGTATTTAAATCTGAGCATGGCAGTTCTACCATAAAAAGTACTCTATTTTTCTAATTTC
TAGGATTTTTAAAATAACATTTCTGTAAGTCTGACATACTAATAGTCACTCAAGCAGTACCATTTATTTTAGTTTGCATATATTTTCACT
GTTTTTAATTTAATGTATTGAGTCTAATAGACTGTTTTGCAATAATTAGAATAAAGATTTATTTCTTCTAATCAAAGATGCATAACAGCT
ATTATCTAGGGGACCACCAAATGTGATTTCAAAATTTTGTTAACTATTACAAATGTAATCCTTATATAGAAATTTTAATTTTGTAAAGTA
GTGTATAATATTGTAATATTAAATTCTTGTTCTTAAATTCAAATATGTATTGATCTTCAATGTGCTGTGTTAAATCTTGCTTCTCTGAAA

>51709_51709_2_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000259050_SEC24A_chr5_134028292_ENST00000398844_length(amino acids)=634AA_BP=113
MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASASPFQSAWYSESEITQGARSRSQNQQRDHDSK
RPKLSCTNCTTSAGRNVGNGLNTLSDVFIPMPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLMSPTGGRMSVFQT
QLPTLGVGALKPREEPNHRSSAKDIHMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQ
KLQKELQRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIR
VHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLSDARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFPLFVLALLKQ
KSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKN
CTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMKANFLQNMIEDRTESALSYYEFLLHIQQ

--------------------------------------------------------------
>51709_51709_3_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000409175_SEC24A_chr5_134028292_ENST00000322887_length(transcript)=1330nt_BP=606nt
ACTTAACGGTGGTGGCTGGTTCTGCGCCGGATCCGGGAGAGGGGCGGGCGCCATTGTGCTTCGCTGCCGACTGCATTTCCTCAGTCACGG
GCCTAGAACTCCAAGGAGAAAGGCGGCGGAATTCATGATTTGTTCCTGTAGCTGAAACATACATTGAATGCTTTCTGCCCTGGCATGAAC
TTACATGGTCAGAGCTGGTTTTTCCTGCCCTCAAATATATTTCTCTGACTCTACCGGTTAGACTAGAAAAATCTTTAAGAATGGAGTCTA
AACCTTCAAGGATTCCAAGAAGAATTTCTGTTCAACCTTCCAGCTCCTTAAGTGCTAGGATGATGTCTGGAAGCAGAGGAAGTAGTTTAA
ATGATACCTATCACTCAAGAGACTCTTCATTTAGATTGGATTCTGAATATCAGTCTACATCAGCATCAGCATCTGCGTCACCATTTCAAT
CTGCATGGTATAGTGAATCTGAGATAACTCAGGGAGCACGCTCAAGATCGCAGAACCAGCAACGGGATCATGATTCAAAAAGACCTAAAC
TTTCCTGTACAAACTGTACTACCTCAGCTGGGAGAAATGTTGGAAATGGTTTAAACACATTATCAGATGTTTTTATACCTATGCCAGAGA
ACTTATTAGTAAACTTAAATGAAAGTAAAGAGAGTGTCATTGGGGTCAGTTCAGAAGAAACTCTTATTACCTGCCTGGAAATTGCCATGA
GATAATACAGTGAGAGGTGAACAGAATGTGTCTGAAGGGGGGATGTTGTCTACCCTGTACATGCATATATGCCGTAGGGGTAACATTTTA
ACTAGCAAGTCTATGGTCTCTGCTGTTGGCAATGGTGACTGTGCCATAGTGCGAAGTATTTTTTTCCCCATTAACTCTATTTGTACAACC
TAACCTGTAAAGGTAGTTGTTTTTCTTTTGTAGTGATATTACTAGTTGGCAAAGTTACTGGATATCTTAGATTTGCAACAGGGAAGAGCT
AAACTCGCTTTGGAACTTACAAGAATAAAGTATGTAGAGGTGATGGAGAAGGCCATATTTCATGGCATTAAAATACATCAAATCTCTAAA
CTGTGATGGTTCTTTTGGATACATTTTGGACTTATAGTCTTGCTGGACTACTGCATGTGCAAGAACTGTAAGGCCCAACTTTGATTTGTC
TTGCTTGCCAATTTATAATGTTGACTTAAAATGGCTTTCTTGTCATTTGACCAACTTCATTGTTTAGTGTCTGTAGATTCTCTGACCATC

>51709_51709_3_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000409175_SEC24A_chr5_134028292_ENST00000322887_length(amino acids)=186AA_BP=145
MPWHELTWSELVFPALKYISLTLPVRLEKSLRMESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASAS
ASPFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDVFIPMPENLLVNLNESKESVIGVSSEETLITC

--------------------------------------------------------------
>51709_51709_4_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000409175_SEC24A_chr5_134028292_ENST00000398844_length(transcript)=4894nt_BP=606nt
ACTTAACGGTGGTGGCTGGTTCTGCGCCGGATCCGGGAGAGGGGCGGGCGCCATTGTGCTTCGCTGCCGACTGCATTTCCTCAGTCACGG
GCCTAGAACTCCAAGGAGAAAGGCGGCGGAATTCATGATTTGTTCCTGTAGCTGAAACATACATTGAATGCTTTCTGCCCTGGCATGAAC
TTACATGGTCAGAGCTGGTTTTTCCTGCCCTCAAATATATTTCTCTGACTCTACCGGTTAGACTAGAAAAATCTTTAAGAATGGAGTCTA
AACCTTCAAGGATTCCAAGAAGAATTTCTGTTCAACCTTCCAGCTCCTTAAGTGCTAGGATGATGTCTGGAAGCAGAGGAAGTAGTTTAA
ATGATACCTATCACTCAAGAGACTCTTCATTTAGATTGGATTCTGAATATCAGTCTACATCAGCATCAGCATCTGCGTCACCATTTCAAT
CTGCATGGTATAGTGAATCTGAGATAACTCAGGGAGCACGCTCAAGATCGCAGAACCAGCAACGGGATCATGATTCAAAAAGACCTAAAC
TTTCCTGTACAAACTGTACTACCTCAGCTGGGAGAAATGTTGGAAATGGTTTAAACACATTATCAGATGTTTTTATACCTATGCCAGAGA
ACTTATTAGTAAACTTAAATGAAAGTAAAGAGCTCGTGCAAGATTTACTGAAAACTTTGCCACAAATGTTTACCAAGACTCTGGAGACCC
AGAGTGCCTTGGGTCCTGCACTGCAGGCTGCCTTTAAGCTGATGTCTCCAACTGGTGGTCGAATGTCTGTCTTTCAAACACAACTCCCAA
CTCTTGGAGTGGGAGCCCTGAAACCACGAGAGGAACCAAACCACAGGTCATCTGCTAAGGATATACACATGACACCATCCACTGACTTCT
ATAAGAAATTAGCCTTGGACTGTTCTGGTCAGCAAGTTGCTGTTGACTTATTCCTTCTCAGTGGACAGTATTCTGATTTGGCTTCTCTGG
GTTGTATTTCTCGGTATTCAGCAGGTAGTGTCTATTACTATCCCTCTTACCATCATCAGCACAACCCAGTCCAAGTACAGAAATTACAGA
AGGAACTACAGAGATACCTTACTCGGAAGATTGGCTTTGAGGCAGTCATGAGGATTCGGTGCACCAAAGGTCTTTCCATTCATACTTTCC
ATGGAAACTTCTTTGTTAGGTCAACCGACTTACTGTCTTTGCCTAACGTCAACCCAGACGCTGGGTATGCAGTACAGATGTCAGTGGAAG
AGAGTCTTACTGACACTCAGTTGGTTTCTTTTCAGTCAGCACTCTTGTATACATCCAGCAAAGGCGAAAGAAGAATTCGTGTTCATACTT
TGTGTTTGCCAGTAGTTTCGACTCTGAATGATGTCTTTCTTGGAGCTGATGTTCAAGCAATTTCAGGGTTATTGGCCAATATGGCTGTTG
ACAGATCTATGACTGCCAGTCTGAGTGACGCTCGGGATGCTCTAGTGAATGCAGTCATTGACTCCCTTTCAGCTTACCGTTCTTCAGTCT
TAAGTAACCAGCAGCCTGGACTCATGGTTCCTTTTTCTTTGCGGCTTTTCCCACTTTTTGTGTTGGCTCTCCTTAAACAGAAATCATTCC
AGACTGGGACAAATGCACGTCTAGATGAACGCATTTTTGCTATGTGTCAAGTGAAAAACCAGCCCTTGGTTTACCTTATGCTCACAACTC
ATCCCAGTTTGTATAGAGTTGACAATCTCTCAGATGAGGGAGCACTCAACATCAGTGATAGAACCATACCTCAGCCCCCCATTCTTCAGC
TTTCAGTGGAGAAGCTGAGCAGAGATGGAGCTTTCCTCATGGATGCAGGCTCTGTACTGATGCTTTGGGTTGGAAAAAATTGTACACAGA
ATTTTCTCAGCCAAGTTCTAGGAGTTCAAAACTATGCATCAATTCCACAGCCTATGACAGACCTTCCAGAACTTGATACACCAGAATCTG
CCAGAATAATAGCTTTCATCTCTTGGCTTAGAGAGCAGAGACCATTTTTCCCAATACTTTATGTAATAAGGGATGAGAGTCCAATGAAAG
CAAACTTCCTTCAAAACATGATAGAAGACAGAACAGAATCTGCATTATCATATTATGAATTCCTGTTGCATATACAGCAACAAGTGAATA
AATGAATGAATGAAGAAATTTGACTTATTTTTAAGGAATGTCACGATAGTGCAGAATACCTGGAAATGTGTAATACCTTCTTTTTCTATT
ATGTTTGTGGACTAATGTGATGATTGAGATGTTCTCACTGTGATTTCAACAACCTATAGCAAATAAAAGACCACAGCAGAGAATCAAACA
TGCAACTCTGAAATACTGTATTTTTCAAATCAGAATATAGCTACGTATGATTGGATACTTTTTTCTTGCCAATTATGTTTGAGTTGTTAT
GGATTAAAATAAGAATATTGCAGAGGCAAAGTACATTTTGTAAAATAAAGATTTCTGTGTTCTACATGTATATTTCTCATTTTTAATTTT
TCTGAATCTTTGGCTGCTACATTTAAAACCTCACAAACCTAAGTGTTGCAGGGAAGTTACAAATTGATTGGTAGTGATGTTTTTAAAATA
AAAACAATGGAAAGTAAATATAATGTAGGAAAACTAGAATTCATTCCCCACACGTGTCTTTTTTTTTTCTTTGTTAAGGGAAAGGATCAT
GTTGACTAAAACTAAACTAATTCTAGTATAGCTTGAGAAAAATATGAAGAAACACATTCAAGCTTTAAAATCTGTCAGTATTCTTTATGC
TTGAAGAACAAAGTCACTTTGATTTGAAGTGAGAACTATCATTAGGTGGTTTTCTGATTTCCTGATGAAGAGTTGGACATACTGTCTTAA
TCTATAGTGAAAAGAATTTGAGCTGTCTTCATAAACACTGGGACTAGCAATGATAATAGGGAGATAAGAAACTTTAATTATCTTGATCCT
TTAAGTGGATTTTATTTGGTGCATTTCTGCTCTGGGTATATAATAAAAGTGGGGGTTTTTGGTGAAATGAGTGAAGAAATGAAAGGTTTC
TAAAGTGCTATCCAAATACATCAGTAACATTTTTCTAAGGAGTTTAATTGTTAAATTGGAAGTCATTCATAAGAAATATTTATGCTTGAA
TATGAAAATCTATGAAAGCATAAATGCTGCTGTTTGATTTGGTGGATATTAAGATTATACACATCCAACATATTAAAGTTATGAAAGAAA
CTTGACTTCTGAAAATCCTTAAGAGACTGCTTTCTTGATTCAGCTAGAGAAATATTATAGTCAAAACTATTGAGTGAATTTTGTTTACAA
ATAGGTAAATTATACATTTGTATATTTAAAGTGCTGTGACATAGTATCTTTAAGAGTTTGGCTCAGTTTTCACAGATTCATTTTGTCTTA
AGAATTTCTTAAATATGTTCATGTATAATACTTGATCAAAATATTTTTGGGTTTTTTGTTTTGTTTTAATGGGTTAGAAAATGTTTACAA
TCTTGGTCTTATATGATCACCAATGGAATAGTAACTTCCAGGTTTATATCAATATGAGCTGACTTTAACTGAGTTGTTTGGGATAGGGAA
GAAGCAGTCCCTCTACAGTATACAACTACTGCTTGCCAGCTGGATCAAAATAATCATGTTTTATGAAAATATCTCCCTTAAGCAGTGTTA
AGGTTGGTTTGCAGTGTGTAAGTGGCACATTGAACTGGAAGTTTTCTTGAAAGCTGCTTCATCTATTAAGAAGCAATTTTCAAATTGTAG
CGAATTATATTATCCCCTCTTTTAAAGAAACAGTCGTTATATGCTGATGTTTCTTAAAATAACTAAAATGTTCCTCTTAATGTGATTTTA
AATGGAGTTATTTGTAGGTCCTTTCTTAGTAGTAAAGAATCTTCTAGAGGGAAACATTTGTGCTTTTAGGGATAATCTTCCTTGTGCCTC
ACTACATCCCTAAGTGGGTATGACTCTTGTTATTACCACATGCTTTTTTAGTATATTTCACAAATTTACTTTTAAATATTATTTTAGATA
CGGTGTAACATGTGCAATTCAGAATAATTTTATAACAGGTCATGAAAAACATAACTTTAGTTAGGATTCACAATATTTGTTCTCCACATA
ATGAGAGAATGAATGAGCCTTTGGAGATACTGATATAAGGCAATTATTTTTTGCAATGTTGAATGTGTTTTTTAGTTTGATTCTTTTTTT
TTCCCCCAATAGGGCACTACCTGCCATATCATCTTGTATTACTTTTTGATGTAAAGCGACTAATATTTACACTATGCCATATTTTTTTTA
ATTATAGTTGTAAATTATGAAAGATCCTTGAATTTTCTACAGATCTACAACTACTAATGTAACAGACAAGGGCAATCTTGGTATTTAAAT
CTGAGCATGGCAGTTCTACCATAAAAAGTACTCTATTTTTCTAATTTCTAGGATTTTTAAAATAACATTTCTGTAAGTCTGACATACTAA
TAGTCACTCAAGCAGTACCATTTATTTTAGTTTGCATATATTTTCACTGTTTTTAATTTAATGTATTGAGTCTAATAGACTGTTTTGCAA
TAATTAGAATAAAGATTTATTTCTTCTAATCAAAGATGCATAACAGCTATTATCTAGGGGACCACCAAATGTGATTTCAAAATTTTGTTA
ACTATTACAAATGTAATCCTTATATAGAAATTTTAATTTTGTAAAGTAGTGTATAATATTGTAATATTAAATTCTTGTTCTTAAATTCAA
ATATGTATTGATCTTCAATGTGCTGTGTTAAATCTTGCTTCTCTGAAAAGTTGGAGACAAGATTTGTCTTCCTTTTTACAGTTTGTAATT

>51709_51709_4_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000409175_SEC24A_chr5_134028292_ENST00000398844_length(amino acids)=666AA_BP=145
MPWHELTWSELVFPALKYISLTLPVRLEKSLRMESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASAS
ASPFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDVFIPMPENLLVNLNESKELVQDLLKTLPQMFT
KTLETQSALGPALQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREEPNHRSSAKDIHMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYS
DLASLGCISRYSAGSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAV
QMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLSDARDALVNAVIDSLSA
YRSSVLSNQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQ
PPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRD

--------------------------------------------------------------
>51709_51709_5_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000409591_SEC24A_chr5_134028292_ENST00000322887_length(transcript)=1035nt_BP=311nt
TTTGTAAGCTGCGCTTCACCTGCTACTAATCTTGCTGTTACTTCTGCTATCCCATCTTTAAATTTTTATCACAATTTGAATGATTGGCAA
CTATGATCATCTTATGTCTTTAGTAACATCTACATCAGCATCAGCATCTGCGTCACCATTTCAATCTGCATGGTATAGTGAATCTGAGAT
AACTCAGGGAGCACGCTCAAGATCGCAGAACCAGCAACGGGATCATGATTCAAAAAGACCTAAACTTTCCTGTACAAACTGTACTACCTC
AGCTGGGAGAAATGTTGGAAATGGTTTAAACACATTATCAGATGTTTTTATACCTATGCCAGAGAACTTATTAGTAAACTTAAATGAAAG
TAAAGAGAGTGTCATTGGGGTCAGTTCAGAAGAAACTCTTATTACCTGCCTGGAAATTGCCATGAGATAATACAGTGAGAGGTGAACAGA
ATGTGTCTGAAGGGGGGATGTTGTCTACCCTGTACATGCATATATGCCGTAGGGGTAACATTTTAACTAGCAAGTCTATGGTCTCTGCTG
TTGGCAATGGTGACTGTGCCATAGTGCGAAGTATTTTTTTCCCCATTAACTCTATTTGTACAACCTAACCTGTAAAGGTAGTTGTTTTTC
TTTTGTAGTGATATTACTAGTTGGCAAAGTTACTGGATATCTTAGATTTGCAACAGGGAAGAGCTAAACTCGCTTTGGAACTTACAAGAA
TAAAGTATGTAGAGGTGATGGAGAAGGCCATATTTCATGGCATTAAAATACATCAAATCTCTAAACTGTGATGGTTCTTTTGGATACATT
TTGGACTTATAGTCTTGCTGGACTACTGCATGTGCAAGAACTGTAAGGCCCAACTTTGATTTGTCTTGCTTGCCAATTTATAATGTTGAC
TTAAAATGGCTTTCTTGTCATTTGACCAACTTCATTGTTTAGTGTCTGTAGATTCTCTGACCATCATCATGACTCAATGTCTTGTCTATT

>51709_51709_5_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000409591_SEC24A_chr5_134028292_ENST00000322887_length(amino acids)=116AA_BP=75
MIGNYDHLMSLVTSTSASASASPFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDVFIPMPENLLVN

--------------------------------------------------------------
>51709_51709_6_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000409591_SEC24A_chr5_134028292_ENST00000398844_length(transcript)=4599nt_BP=311nt
TTTGTAAGCTGCGCTTCACCTGCTACTAATCTTGCTGTTACTTCTGCTATCCCATCTTTAAATTTTTATCACAATTTGAATGATTGGCAA
CTATGATCATCTTATGTCTTTAGTAACATCTACATCAGCATCAGCATCTGCGTCACCATTTCAATCTGCATGGTATAGTGAATCTGAGAT
AACTCAGGGAGCACGCTCAAGATCGCAGAACCAGCAACGGGATCATGATTCAAAAAGACCTAAACTTTCCTGTACAAACTGTACTACCTC
AGCTGGGAGAAATGTTGGAAATGGTTTAAACACATTATCAGATGTTTTTATACCTATGCCAGAGAACTTATTAGTAAACTTAAATGAAAG
TAAAGAGCTCGTGCAAGATTTACTGAAAACTTTGCCACAAATGTTTACCAAGACTCTGGAGACCCAGAGTGCCTTGGGTCCTGCACTGCA
GGCTGCCTTTAAGCTGATGTCTCCAACTGGTGGTCGAATGTCTGTCTTTCAAACACAACTCCCAACTCTTGGAGTGGGAGCCCTGAAACC
ACGAGAGGAACCAAACCACAGGTCATCTGCTAAGGATATACACATGACACCATCCACTGACTTCTATAAGAAATTAGCCTTGGACTGTTC
TGGTCAGCAAGTTGCTGTTGACTTATTCCTTCTCAGTGGACAGTATTCTGATTTGGCTTCTCTGGGTTGTATTTCTCGGTATTCAGCAGG
TAGTGTCTATTACTATCCCTCTTACCATCATCAGCACAACCCAGTCCAAGTACAGAAATTACAGAAGGAACTACAGAGATACCTTACTCG
GAAGATTGGCTTTGAGGCAGTCATGAGGATTCGGTGCACCAAAGGTCTTTCCATTCATACTTTCCATGGAAACTTCTTTGTTAGGTCAAC
CGACTTACTGTCTTTGCCTAACGTCAACCCAGACGCTGGGTATGCAGTACAGATGTCAGTGGAAGAGAGTCTTACTGACACTCAGTTGGT
TTCTTTTCAGTCAGCACTCTTGTATACATCCAGCAAAGGCGAAAGAAGAATTCGTGTTCATACTTTGTGTTTGCCAGTAGTTTCGACTCT
GAATGATGTCTTTCTTGGAGCTGATGTTCAAGCAATTTCAGGGTTATTGGCCAATATGGCTGTTGACAGATCTATGACTGCCAGTCTGAG
TGACGCTCGGGATGCTCTAGTGAATGCAGTCATTGACTCCCTTTCAGCTTACCGTTCTTCAGTCTTAAGTAACCAGCAGCCTGGACTCAT
GGTTCCTTTTTCTTTGCGGCTTTTCCCACTTTTTGTGTTGGCTCTCCTTAAACAGAAATCATTCCAGACTGGGACAAATGCACGTCTAGA
TGAACGCATTTTTGCTATGTGTCAAGTGAAAAACCAGCCCTTGGTTTACCTTATGCTCACAACTCATCCCAGTTTGTATAGAGTTGACAA
TCTCTCAGATGAGGGAGCACTCAACATCAGTGATAGAACCATACCTCAGCCCCCCATTCTTCAGCTTTCAGTGGAGAAGCTGAGCAGAGA
TGGAGCTTTCCTCATGGATGCAGGCTCTGTACTGATGCTTTGGGTTGGAAAAAATTGTACACAGAATTTTCTCAGCCAAGTTCTAGGAGT
TCAAAACTATGCATCAATTCCACAGCCTATGACAGACCTTCCAGAACTTGATACACCAGAATCTGCCAGAATAATAGCTTTCATCTCTTG
GCTTAGAGAGCAGAGACCATTTTTCCCAATACTTTATGTAATAAGGGATGAGAGTCCAATGAAAGCAAACTTCCTTCAAAACATGATAGA
AGACAGAACAGAATCTGCATTATCATATTATGAATTCCTGTTGCATATACAGCAACAAGTGAATAAATGAATGAATGAAGAAATTTGACT
TATTTTTAAGGAATGTCACGATAGTGCAGAATACCTGGAAATGTGTAATACCTTCTTTTTCTATTATGTTTGTGGACTAATGTGATGATT
GAGATGTTCTCACTGTGATTTCAACAACCTATAGCAAATAAAAGACCACAGCAGAGAATCAAACATGCAACTCTGAAATACTGTATTTTT
CAAATCAGAATATAGCTACGTATGATTGGATACTTTTTTCTTGCCAATTATGTTTGAGTTGTTATGGATTAAAATAAGAATATTGCAGAG
GCAAAGTACATTTTGTAAAATAAAGATTTCTGTGTTCTACATGTATATTTCTCATTTTTAATTTTTCTGAATCTTTGGCTGCTACATTTA
AAACCTCACAAACCTAAGTGTTGCAGGGAAGTTACAAATTGATTGGTAGTGATGTTTTTAAAATAAAAACAATGGAAAGTAAATATAATG
TAGGAAAACTAGAATTCATTCCCCACACGTGTCTTTTTTTTTTCTTTGTTAAGGGAAAGGATCATGTTGACTAAAACTAAACTAATTCTA
GTATAGCTTGAGAAAAATATGAAGAAACACATTCAAGCTTTAAAATCTGTCAGTATTCTTTATGCTTGAAGAACAAAGTCACTTTGATTT
GAAGTGAGAACTATCATTAGGTGGTTTTCTGATTTCCTGATGAAGAGTTGGACATACTGTCTTAATCTATAGTGAAAAGAATTTGAGCTG
TCTTCATAAACACTGGGACTAGCAATGATAATAGGGAGATAAGAAACTTTAATTATCTTGATCCTTTAAGTGGATTTTATTTGGTGCATT
TCTGCTCTGGGTATATAATAAAAGTGGGGGTTTTTGGTGAAATGAGTGAAGAAATGAAAGGTTTCTAAAGTGCTATCCAAATACATCAGT
AACATTTTTCTAAGGAGTTTAATTGTTAAATTGGAAGTCATTCATAAGAAATATTTATGCTTGAATATGAAAATCTATGAAAGCATAAAT
GCTGCTGTTTGATTTGGTGGATATTAAGATTATACACATCCAACATATTAAAGTTATGAAAGAAACTTGACTTCTGAAAATCCTTAAGAG
ACTGCTTTCTTGATTCAGCTAGAGAAATATTATAGTCAAAACTATTGAGTGAATTTTGTTTACAAATAGGTAAATTATACATTTGTATAT
TTAAAGTGCTGTGACATAGTATCTTTAAGAGTTTGGCTCAGTTTTCACAGATTCATTTTGTCTTAAGAATTTCTTAAATATGTTCATGTA
TAATACTTGATCAAAATATTTTTGGGTTTTTTGTTTTGTTTTAATGGGTTAGAAAATGTTTACAATCTTGGTCTTATATGATCACCAATG
GAATAGTAACTTCCAGGTTTATATCAATATGAGCTGACTTTAACTGAGTTGTTTGGGATAGGGAAGAAGCAGTCCCTCTACAGTATACAA
CTACTGCTTGCCAGCTGGATCAAAATAATCATGTTTTATGAAAATATCTCCCTTAAGCAGTGTTAAGGTTGGTTTGCAGTGTGTAAGTGG
CACATTGAACTGGAAGTTTTCTTGAAAGCTGCTTCATCTATTAAGAAGCAATTTTCAAATTGTAGCGAATTATATTATCCCCTCTTTTAA
AGAAACAGTCGTTATATGCTGATGTTTCTTAAAATAACTAAAATGTTCCTCTTAATGTGATTTTAAATGGAGTTATTTGTAGGTCCTTTC
TTAGTAGTAAAGAATCTTCTAGAGGGAAACATTTGTGCTTTTAGGGATAATCTTCCTTGTGCCTCACTACATCCCTAAGTGGGTATGACT
CTTGTTATTACCACATGCTTTTTTAGTATATTTCACAAATTTACTTTTAAATATTATTTTAGATACGGTGTAACATGTGCAATTCAGAAT
AATTTTATAACAGGTCATGAAAAACATAACTTTAGTTAGGATTCACAATATTTGTTCTCCACATAATGAGAGAATGAATGAGCCTTTGGA
GATACTGATATAAGGCAATTATTTTTTGCAATGTTGAATGTGTTTTTTAGTTTGATTCTTTTTTTTTCCCCCAATAGGGCACTACCTGCC
ATATCATCTTGTATTACTTTTTGATGTAAAGCGACTAATATTTACACTATGCCATATTTTTTTTAATTATAGTTGTAAATTATGAAAGAT
CCTTGAATTTTCTACAGATCTACAACTACTAATGTAACAGACAAGGGCAATCTTGGTATTTAAATCTGAGCATGGCAGTTCTACCATAAA
AAGTACTCTATTTTTCTAATTTCTAGGATTTTTAAAATAACATTTCTGTAAGTCTGACATACTAATAGTCACTCAAGCAGTACCATTTAT
TTTAGTTTGCATATATTTTCACTGTTTTTAATTTAATGTATTGAGTCTAATAGACTGTTTTGCAATAATTAGAATAAAGATTTATTTCTT
CTAATCAAAGATGCATAACAGCTATTATCTAGGGGACCACCAAATGTGATTTCAAAATTTTGTTAACTATTACAAATGTAATCCTTATAT
AGAAATTTTAATTTTGTAAAGTAGTGTATAATATTGTAATATTAAATTCTTGTTCTTAAATTCAAATATGTATTGATCTTCAATGTGCTG
TGTTAAATCTTGCTTCTCTGAAAAGTTGGAGACAAGATTTGTCTTCCTTTTTACAGTTTGTAATTTTCACTGTTTTATTCCTGTTAAAAA

>51709_51709_6_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000409591_SEC24A_chr5_134028292_ENST00000398844_length(amino acids)=596AA_BP=75
MIGNYDHLMSLVTSTSASASASPFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDVFIPMPENLLVN
LNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREEPNHRSSAKDIHMTPSTDFYKKLA
LDCSGQQVAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFF
VRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMT
ASLSDARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLY
RVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIA

--------------------------------------------------------------
>51709_51709_7_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000539065_SEC24A_chr5_134028292_ENST00000322887_length(transcript)=1202nt_BP=478nt
ACTTAACGGTGGTGGCTGGTTCTGCGCCGGATCCGGGAGAGGGGCGGGCGCCATTGTGCTTCGCTGCCGACTGCATTTCCTCAGTCACGG
GCCTAGAACTCCAAGGAGAAAGGCGGCGAAAAATCTTTAAGAATGGAGTCTAAACCTTCAAGGATTCCAAGAAGAATTTCTGTTCAACCT
TCCAGCTCCTTAAGTGCTAGGATGATGTCTGGAAGCAGAGGAAGTAGTTTAAATGATACCTATCACTCAAGAGACTCTTCATTTAGATTG
GATTCTGAATATCAGTCTACATCAGCATCAGCATCTGCGTCACCATTTCAATCTGCATGGTATAGTGAATCTGAGATAACTCAGGGAGCA
CGCTCAAGATCGCAGAACCAGCAACGGGATCATGATTCAAAAAGACCTAAACTTTCCTGTACAAACTGTACTACCTCAGCTGGGAGAAAT
GTTGGAAATGGTTTAAACACATTATCAGATGTTTTTATACCTATGCCAGAGAACTTATTAGTAAACTTAAATGAAAGTAAAGAGAGTGTC
ATTGGGGTCAGTTCAGAAGAAACTCTTATTACCTGCCTGGAAATTGCCATGAGATAATACAGTGAGAGGTGAACAGAATGTGTCTGAAGG
GGGGATGTTGTCTACCCTGTACATGCATATATGCCGTAGGGGTAACATTTTAACTAGCAAGTCTATGGTCTCTGCTGTTGGCAATGGTGA
CTGTGCCATAGTGCGAAGTATTTTTTTCCCCATTAACTCTATTTGTACAACCTAACCTGTAAAGGTAGTTGTTTTTCTTTTGTAGTGATA
TTACTAGTTGGCAAAGTTACTGGATATCTTAGATTTGCAACAGGGAAGAGCTAAACTCGCTTTGGAACTTACAAGAATAAAGTATGTAGA
GGTGATGGAGAAGGCCATATTTCATGGCATTAAAATACATCAAATCTCTAAACTGTGATGGTTCTTTTGGATACATTTTGGACTTATAGT
CTTGCTGGACTACTGCATGTGCAAGAACTGTAAGGCCCAACTTTGATTTGTCTTGCTTGCCAATTTATAATGTTGACTTAAAATGGCTTT
CTTGTCATTTGACCAACTTCATTGTTTAGTGTCTGTAGATTCTCTGACCATCATCATGACTCAATGTCTTGTCTATTGTATGAGATACTG

>51709_51709_7_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000539065_SEC24A_chr5_134028292_ENST00000322887_length(amino acids)=154AA_BP=113
MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASASPFQSAWYSESEITQGARSRSQNQQRDHDSK

--------------------------------------------------------------
>51709_51709_8_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000539065_SEC24A_chr5_134028292_ENST00000398844_length(transcript)=4766nt_BP=478nt
ACTTAACGGTGGTGGCTGGTTCTGCGCCGGATCCGGGAGAGGGGCGGGCGCCATTGTGCTTCGCTGCCGACTGCATTTCCTCAGTCACGG
GCCTAGAACTCCAAGGAGAAAGGCGGCGAAAAATCTTTAAGAATGGAGTCTAAACCTTCAAGGATTCCAAGAAGAATTTCTGTTCAACCT
TCCAGCTCCTTAAGTGCTAGGATGATGTCTGGAAGCAGAGGAAGTAGTTTAAATGATACCTATCACTCAAGAGACTCTTCATTTAGATTG
GATTCTGAATATCAGTCTACATCAGCATCAGCATCTGCGTCACCATTTCAATCTGCATGGTATAGTGAATCTGAGATAACTCAGGGAGCA
CGCTCAAGATCGCAGAACCAGCAACGGGATCATGATTCAAAAAGACCTAAACTTTCCTGTACAAACTGTACTACCTCAGCTGGGAGAAAT
GTTGGAAATGGTTTAAACACATTATCAGATGTTTTTATACCTATGCCAGAGAACTTATTAGTAAACTTAAATGAAAGTAAAGAGCTCGTG
CAAGATTTACTGAAAACTTTGCCACAAATGTTTACCAAGACTCTGGAGACCCAGAGTGCCTTGGGTCCTGCACTGCAGGCTGCCTTTAAG
CTGATGTCTCCAACTGGTGGTCGAATGTCTGTCTTTCAAACACAACTCCCAACTCTTGGAGTGGGAGCCCTGAAACCACGAGAGGAACCA
AACCACAGGTCATCTGCTAAGGATATACACATGACACCATCCACTGACTTCTATAAGAAATTAGCCTTGGACTGTTCTGGTCAGCAAGTT
GCTGTTGACTTATTCCTTCTCAGTGGACAGTATTCTGATTTGGCTTCTCTGGGTTGTATTTCTCGGTATTCAGCAGGTAGTGTCTATTAC
TATCCCTCTTACCATCATCAGCACAACCCAGTCCAAGTACAGAAATTACAGAAGGAACTACAGAGATACCTTACTCGGAAGATTGGCTTT
GAGGCAGTCATGAGGATTCGGTGCACCAAAGGTCTTTCCATTCATACTTTCCATGGAAACTTCTTTGTTAGGTCAACCGACTTACTGTCT
TTGCCTAACGTCAACCCAGACGCTGGGTATGCAGTACAGATGTCAGTGGAAGAGAGTCTTACTGACACTCAGTTGGTTTCTTTTCAGTCA
GCACTCTTGTATACATCCAGCAAAGGCGAAAGAAGAATTCGTGTTCATACTTTGTGTTTGCCAGTAGTTTCGACTCTGAATGATGTCTTT
CTTGGAGCTGATGTTCAAGCAATTTCAGGGTTATTGGCCAATATGGCTGTTGACAGATCTATGACTGCCAGTCTGAGTGACGCTCGGGAT
GCTCTAGTGAATGCAGTCATTGACTCCCTTTCAGCTTACCGTTCTTCAGTCTTAAGTAACCAGCAGCCTGGACTCATGGTTCCTTTTTCT
TTGCGGCTTTTCCCACTTTTTGTGTTGGCTCTCCTTAAACAGAAATCATTCCAGACTGGGACAAATGCACGTCTAGATGAACGCATTTTT
GCTATGTGTCAAGTGAAAAACCAGCCCTTGGTTTACCTTATGCTCACAACTCATCCCAGTTTGTATAGAGTTGACAATCTCTCAGATGAG
GGAGCACTCAACATCAGTGATAGAACCATACCTCAGCCCCCCATTCTTCAGCTTTCAGTGGAGAAGCTGAGCAGAGATGGAGCTTTCCTC
ATGGATGCAGGCTCTGTACTGATGCTTTGGGTTGGAAAAAATTGTACACAGAATTTTCTCAGCCAAGTTCTAGGAGTTCAAAACTATGCA
TCAATTCCACAGCCTATGACAGACCTTCCAGAACTTGATACACCAGAATCTGCCAGAATAATAGCTTTCATCTCTTGGCTTAGAGAGCAG
AGACCATTTTTCCCAATACTTTATGTAATAAGGGATGAGAGTCCAATGAAAGCAAACTTCCTTCAAAACATGATAGAAGACAGAACAGAA
TCTGCATTATCATATTATGAATTCCTGTTGCATATACAGCAACAAGTGAATAAATGAATGAATGAAGAAATTTGACTTATTTTTAAGGAA
TGTCACGATAGTGCAGAATACCTGGAAATGTGTAATACCTTCTTTTTCTATTATGTTTGTGGACTAATGTGATGATTGAGATGTTCTCAC
TGTGATTTCAACAACCTATAGCAAATAAAAGACCACAGCAGAGAATCAAACATGCAACTCTGAAATACTGTATTTTTCAAATCAGAATAT
AGCTACGTATGATTGGATACTTTTTTCTTGCCAATTATGTTTGAGTTGTTATGGATTAAAATAAGAATATTGCAGAGGCAAAGTACATTT
TGTAAAATAAAGATTTCTGTGTTCTACATGTATATTTCTCATTTTTAATTTTTCTGAATCTTTGGCTGCTACATTTAAAACCTCACAAAC
CTAAGTGTTGCAGGGAAGTTACAAATTGATTGGTAGTGATGTTTTTAAAATAAAAACAATGGAAAGTAAATATAATGTAGGAAAACTAGA
ATTCATTCCCCACACGTGTCTTTTTTTTTTCTTTGTTAAGGGAAAGGATCATGTTGACTAAAACTAAACTAATTCTAGTATAGCTTGAGA
AAAATATGAAGAAACACATTCAAGCTTTAAAATCTGTCAGTATTCTTTATGCTTGAAGAACAAAGTCACTTTGATTTGAAGTGAGAACTA
TCATTAGGTGGTTTTCTGATTTCCTGATGAAGAGTTGGACATACTGTCTTAATCTATAGTGAAAAGAATTTGAGCTGTCTTCATAAACAC
TGGGACTAGCAATGATAATAGGGAGATAAGAAACTTTAATTATCTTGATCCTTTAAGTGGATTTTATTTGGTGCATTTCTGCTCTGGGTA
TATAATAAAAGTGGGGGTTTTTGGTGAAATGAGTGAAGAAATGAAAGGTTTCTAAAGTGCTATCCAAATACATCAGTAACATTTTTCTAA
GGAGTTTAATTGTTAAATTGGAAGTCATTCATAAGAAATATTTATGCTTGAATATGAAAATCTATGAAAGCATAAATGCTGCTGTTTGAT
TTGGTGGATATTAAGATTATACACATCCAACATATTAAAGTTATGAAAGAAACTTGACTTCTGAAAATCCTTAAGAGACTGCTTTCTTGA
TTCAGCTAGAGAAATATTATAGTCAAAACTATTGAGTGAATTTTGTTTACAAATAGGTAAATTATACATTTGTATATTTAAAGTGCTGTG
ACATAGTATCTTTAAGAGTTTGGCTCAGTTTTCACAGATTCATTTTGTCTTAAGAATTTCTTAAATATGTTCATGTATAATACTTGATCA
AAATATTTTTGGGTTTTTTGTTTTGTTTTAATGGGTTAGAAAATGTTTACAATCTTGGTCTTATATGATCACCAATGGAATAGTAACTTC
CAGGTTTATATCAATATGAGCTGACTTTAACTGAGTTGTTTGGGATAGGGAAGAAGCAGTCCCTCTACAGTATACAACTACTGCTTGCCA
GCTGGATCAAAATAATCATGTTTTATGAAAATATCTCCCTTAAGCAGTGTTAAGGTTGGTTTGCAGTGTGTAAGTGGCACATTGAACTGG
AAGTTTTCTTGAAAGCTGCTTCATCTATTAAGAAGCAATTTTCAAATTGTAGCGAATTATATTATCCCCTCTTTTAAAGAAACAGTCGTT
ATATGCTGATGTTTCTTAAAATAACTAAAATGTTCCTCTTAATGTGATTTTAAATGGAGTTATTTGTAGGTCCTTTCTTAGTAGTAAAGA
ATCTTCTAGAGGGAAACATTTGTGCTTTTAGGGATAATCTTCCTTGTGCCTCACTACATCCCTAAGTGGGTATGACTCTTGTTATTACCA
CATGCTTTTTTAGTATATTTCACAAATTTACTTTTAAATATTATTTTAGATACGGTGTAACATGTGCAATTCAGAATAATTTTATAACAG
GTCATGAAAAACATAACTTTAGTTAGGATTCACAATATTTGTTCTCCACATAATGAGAGAATGAATGAGCCTTTGGAGATACTGATATAA
GGCAATTATTTTTTGCAATGTTGAATGTGTTTTTTAGTTTGATTCTTTTTTTTTCCCCCAATAGGGCACTACCTGCCATATCATCTTGTA
TTACTTTTTGATGTAAAGCGACTAATATTTACACTATGCCATATTTTTTTTAATTATAGTTGTAAATTATGAAAGATCCTTGAATTTTCT
ACAGATCTACAACTACTAATGTAACAGACAAGGGCAATCTTGGTATTTAAATCTGAGCATGGCAGTTCTACCATAAAAAGTACTCTATTT
TTCTAATTTCTAGGATTTTTAAAATAACATTTCTGTAAGTCTGACATACTAATAGTCACTCAAGCAGTACCATTTATTTTAGTTTGCATA
TATTTTCACTGTTTTTAATTTAATGTATTGAGTCTAATAGACTGTTTTGCAATAATTAGAATAAAGATTTATTTCTTCTAATCAAAGATG
CATAACAGCTATTATCTAGGGGACCACCAAATGTGATTTCAAAATTTTGTTAACTATTACAAATGTAATCCTTATATAGAAATTTTAATT
TTGTAAAGTAGTGTATAATATTGTAATATTAAATTCTTGTTCTTAAATTCAAATATGTATTGATCTTCAATGTGCTGTGTTAAATCTTGC

>51709_51709_8_MARCH7-SEC24A_MARCH7_chr2_160599764_ENST00000539065_SEC24A_chr5_134028292_ENST00000398844_length(amino acids)=634AA_BP=113
MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASASPFQSAWYSESEITQGARSRSQNQQRDHDSK
RPKLSCTNCTTSAGRNVGNGLNTLSDVFIPMPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLMSPTGGRMSVFQT
QLPTLGVGALKPREEPNHRSSAKDIHMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQ
KLQKELQRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIR
VHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLSDARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFPLFVLALLKQ
KSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKN
CTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMKANFLQNMIEDRTESALSYYEFLLHIQQ

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Fusion Gene PPI Analysis for MARCH7-SEC24A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MARCH7-SEC24A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MARCH7-SEC24A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource