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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MARK2-ALDOC (FusionGDB2 ID:51740)

Fusion Gene Summary for MARK2-ALDOC

check button Fusion gene summary
Fusion gene informationFusion gene name: MARK2-ALDOC
Fusion gene ID: 51740
HgeneTgene
Gene symbol

MARK2

ALDOC

Gene ID

2011

230

Gene namemicrotubule affinity regulating kinase 2aldolase, fructose-bisphosphate C
SynonymsEMK-1|EMK1|PAR-1|Par-1b|Par1bALDC
Cytomap

11q13.1

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase MARK2ELKL motif kinase 1MAP/microtubule affinity-regulating kinase 2PAR1 homolog bSer/Thr protein kinase PAR-1Bserine/threonine protein kinase EMKtesticular tissue protein Li 117fructose-bisphosphate aldolase Caldolase 3aldolase C, fructose-bisphosphatebrain-type aldolaseepididymis secretory sperm binding proteinfructoaldolase Cfructose-1,6-biphosphate triosephosphate lyase
Modification date2020032920200313
UniProtAcc

Q7KZI7

P09972

Ensembl transtripts involved in fusion geneENST00000315032, ENST00000350490, 
ENST00000361128, ENST00000377809, 
ENST00000377810, ENST00000402010, 
ENST00000413835, ENST00000502399, 
ENST00000508192, ENST00000513765, 
ENST00000408948, ENST00000425897, 
ENST00000509502, 		ENST00000226253, 
ENST00000395319, ENST00000395321, 
Fusion gene scores* DoF score13 X 9 X 11=12877 X 7 X 2=98
# samples 217
** MAII scorelog2(21/1287*10)=-2.61555082055458
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MARK2 [Title/Abstract] AND ALDOC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMARK2(63676897)-ALDOC(26900284), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMARK2

GO:0006468

protein phosphorylation

14976552

HgeneMARK2

GO:0010976

positive regulation of neuron projection development

12429843

HgeneMARK2

GO:0018105

peptidyl-serine phosphorylation

10542369|16717194

HgeneMARK2

GO:0030010

establishment of cell polarity

12429843

HgeneMARK2

GO:0035556

intracellular signal transduction

14976552

HgeneMARK2

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

15324659

HgeneMARK2

GO:0070507

regulation of microtubule cytoskeleton organization

10542369

TgeneALDOC

GO:0030388

fructose 1,6-bisphosphate metabolic process

9244396|15537755


check buttonFusion gene breakpoints across MARK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ALDOC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI308067MARK2chr11

63676897

-ALDOCchr17

26900284

+


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Fusion Gene ORF analysis for MARK2-ALDOC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000315032ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000315032ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000315032ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000350490ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000350490ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000350490ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000361128ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000361128ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000361128ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000377809ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000377809ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000377809ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000377810ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000377810ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000377810ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000402010ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000402010ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000402010ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000413835ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000413835ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000413835ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000502399ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000502399ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000502399ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000508192ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000508192ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000508192ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000513765ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000513765ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
3UTR-3UTRENST00000513765ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+
intron-3UTRENST00000408948ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
intron-3UTRENST00000408948ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
intron-3UTRENST00000408948ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+
intron-3UTRENST00000425897ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
intron-3UTRENST00000425897ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
intron-3UTRENST00000425897ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+
intron-3UTRENST00000509502ENST00000226253MARK2chr11

63676897

-ALDOCchr17

26900284

+
intron-3UTRENST00000509502ENST00000395319MARK2chr11

63676897

-ALDOCchr17

26900284

+
intron-3UTRENST00000509502ENST00000395321MARK2chr11

63676897

-ALDOCchr17

26900284

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MARK2-ALDOC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MARK2-ALDOC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:63676897/:26900284)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MARK2

Q7KZI7

ALDOC

P09972

FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MARK2-ALDOC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MARK2-ALDOC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MARK2-ALDOC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MARK2-ALDOC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource