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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MARK2-RTN3 (FusionGDB2 ID:51756)

Fusion Gene Summary for MARK2-RTN3

Fusion gene summary

Fusion gene information	Fusion gene name: MARK2-RTN3
	Fusion gene ID: 51756
		Hgene	Tgene
	Gene symbol	MARK2	RTN3
	Gene ID	2011	10313
	Gene name	microtubule affinity regulating kinase 2	reticulon 3
	Synonyms	EMK-1\|EMK1\|PAR-1\|Par-1b\|Par1b	ASYIP\|HAP\|NSPL2\|NSPLII\|RTN3-A1
	Cytomap	11q13.1	11q13.1
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase MARK2ELKL motif kinase 1MAP/microtubule affinity-regulating kinase 2PAR1 homolog bSer/Thr protein kinase PAR-1Bserine/threonine protein kinase EMKtesticular tissue protein Li 117	reticulon-3ASY interacting proteinNSP-like protein 2NSP-like protein IIhomolog of ASY proteinneuroendocrine-specific protein-like 2neuroendocrine-specific protein-like II
	Modification date	20200329	20200327
	UniProtAcc	Q7KZI7	.
	Ensembl transtripts involved in fusion gene	ENST00000315032, ENST00000350490, ENST00000361128, ENST00000377809, ENST00000377810, ENST00000402010, ENST00000408948, ENST00000413835, ENST00000425897, ENST00000502399, ENST00000508192, ENST00000509502, ENST00000513765,	ENST00000538995, ENST00000339997, ENST00000341307, ENST00000354497, ENST00000356000, ENST00000377819, ENST00000537981, ENST00000540798,
Fusion gene scores	* DoF score	13 X 9 X 11=1287	14 X 8 X 8=896
	# samples	21	17
	** MAII score	log2(21/1287*10)=-2.61555082055458 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/896*10)=-2.3979639859199 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MARK2 [Title/Abstract] AND RTN3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MARK2(63607032)-RTN3(63517463), # samples:2
Anticipated loss of major functional domain due to fusion event.	MARK2-RTN3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MARK2-RTN3 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MARK2	GO:0006468	protein phosphorylation	14976552
Hgene	MARK2	GO:0010976	positive regulation of neuron projection development	12429843
Hgene	MARK2	GO:0018105	peptidyl-serine phosphorylation	10542369\|16717194
Hgene	MARK2	GO:0030010	establishment of cell polarity	12429843
Hgene	MARK2	GO:0035556	intracellular signal transduction	14976552
Hgene	MARK2	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	15324659
Hgene	MARK2	GO:0070507	regulation of microtubule cytoskeleton organization	10542369
Tgene	RTN3	GO:0071787	endoplasmic reticulum tubular network formation	25612671

Fusion gene breakpoints across MARK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RTN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A0HY-01A	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
ChimerDB4	OV	TCGA-24-1924-01A	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
ChimerDB4	STAD	TCGA-BR-7851-01A	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
ChimerDB4	STAD	TCGA-BR-7851	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+

Top

Fusion Gene ORF analysis for MARK2-RTN3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000315032	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-3UTR	ENST00000350490	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-3UTR	ENST00000361128	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-3UTR	ENST00000377809	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-3UTR	ENST00000377810	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-3UTR	ENST00000402010	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-3UTR	ENST00000408948	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-3UTR	ENST00000413835	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-3UTR	ENST00000425897	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-3UTR	ENST00000502399	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-3UTR	ENST00000508192	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-3UTR	ENST00000509502	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-3UTR	ENST00000513765	ENST00000538995	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000315032	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000315032	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000315032	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000315032	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000315032	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000315032	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000315032	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000315032	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000315032	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000315032	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000315032	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000315032	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000315032	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000315032	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000315032	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000315032	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000315032	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000315032	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000315032	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000350490	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000350490	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000350490	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000350490	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000350490	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000350490	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000350490	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000350490	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000350490	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000350490	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000350490	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000350490	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000350490	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000350490	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000350490	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000350490	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000350490	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000350490	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000350490	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000361128	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000361128	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000361128	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000361128	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000361128	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000361128	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000361128	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000361128	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000361128	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000361128	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000361128	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000361128	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000361128	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000361128	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000361128	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000361128	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000361128	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000361128	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000361128	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000377809	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377809	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000377809	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000377809	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377809	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377809	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000377809	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000377809	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377809	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377809	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000377809	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000377809	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377809	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000377809	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000377809	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000377809	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000377809	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377809	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000377809	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000377810	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377810	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377810	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377810	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377810	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377810	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000377810	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000402010	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000402010	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000402010	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000402010	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000402010	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000402010	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000402010	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000402010	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000402010	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000402010	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000402010	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000402010	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000402010	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000402010	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000402010	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000402010	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000402010	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000402010	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000402010	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000408948	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000408948	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000408948	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000408948	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000408948	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000408948	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000408948	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000413835	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000413835	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000413835	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000413835	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000413835	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000413835	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000413835	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000413835	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000413835	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000413835	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000413835	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000413835	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000413835	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000413835	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000413835	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000413835	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000413835	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000413835	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000413835	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000425897	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000425897	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000425897	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000425897	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000425897	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000425897	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000425897	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000502399	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000502399	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000502399	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000502399	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000502399	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000502399	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000502399	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000502399	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000502399	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000502399	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000502399	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000502399	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000502399	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000502399	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000502399	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000502399	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000502399	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000502399	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000502399	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000508192	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000508192	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000508192	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000508192	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000508192	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000508192	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000508192	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000508192	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000508192	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000508192	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000508192	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000508192	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000508192	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000508192	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000508192	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000508192	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000508192	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000508192	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5CDS-intron	ENST00000508192	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5CDS-intron	ENST00000509502	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000509502	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000509502	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000509502	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000509502	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000509502	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000509502	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000513765	ENST00000339997	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000513765	ENST00000341307	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000513765	ENST00000354497	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000513765	ENST00000356000	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000513765	ENST00000377819	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000513765	ENST00000537981	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5CDS-intron	ENST00000513765	ENST00000540798	MARK2	chr11	63672515	+	RTN3	chr11	63481443	+
5UTR-3CDS	ENST00000377810	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5UTR-3CDS	ENST00000377810	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5UTR-3CDS	ENST00000377810	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5UTR-3CDS	ENST00000377810	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5UTR-intron	ENST00000377810	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5UTR-intron	ENST00000377810	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5UTR-intron	ENST00000377810	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5UTR-intron	ENST00000377810	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5UTR-intron	ENST00000377810	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5UTR-intron	ENST00000377810	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5UTR-intron	ENST00000377810	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5UTR-intron	ENST00000377810	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5UTR-intron	ENST00000377810	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5UTR-intron	ENST00000377810	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
5UTR-intron	ENST00000377810	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
5UTR-intron	ENST00000377810	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000315032	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000315032	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000315032	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000315032	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000350490	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000350490	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000350490	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000350490	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000361128	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000361128	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000361128	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000361128	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000377809	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000377809	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000377809	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000377809	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000402010	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000402010	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000402010	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000402010	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000413835	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000413835	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000413835	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000413835	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000502399	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000502399	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000502399	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000502399	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000508192	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000508192	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
Frame-shift	ENST00000508192	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
Frame-shift	ENST00000508192	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-3CDS	ENST00000408948	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-3CDS	ENST00000408948	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-3CDS	ENST00000408948	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-3CDS	ENST00000408948	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-3CDS	ENST00000425897	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-3CDS	ENST00000425897	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-3CDS	ENST00000425897	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-3CDS	ENST00000425897	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-3CDS	ENST00000509502	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-3CDS	ENST00000509502	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-3CDS	ENST00000509502	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-3CDS	ENST00000509502	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-3CDS	ENST00000513765	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-3CDS	ENST00000513765	ENST00000341307	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-3CDS	ENST00000513765	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-3CDS	ENST00000513765	ENST00000356000	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000408948	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000408948	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000408948	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000408948	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000408948	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000408948	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000408948	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000408948	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000408948	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000408948	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000408948	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000408948	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000425897	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000425897	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000425897	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000425897	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000425897	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000425897	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000425897	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000425897	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000425897	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000425897	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000425897	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000425897	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000509502	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000509502	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000509502	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000509502	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000509502	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000509502	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000509502	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000509502	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000509502	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000509502	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000509502	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000509502	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000513765	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000513765	ENST00000339997	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000513765	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000513765	ENST00000354497	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000513765	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000513765	ENST00000377819	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000513765	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000513765	ENST00000537981	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000513765	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000513765	ENST00000538995	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+
intron-intron	ENST00000513765	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517463	+
intron-intron	ENST00000513765	ENST00000540798	MARK2	chr11	63607032	+	RTN3	chr11	63517462	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MARK2-RTN3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MARK2-RTN3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:63607032/:63517463)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MARK2 Q7KZI7	.
FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269\|PubMed:11433294, ECO:0000269\|PubMed:12429843, ECO:0000269\|PubMed:14976552, ECO:0000269\|PubMed:15158914, ECO:0000269\|PubMed:15324659, ECO:0000269\|PubMed:15365179, ECO:0000269\|PubMed:16775013, ECO:0000269\|PubMed:16980613, ECO:0000269\|PubMed:18626018, ECO:0000269\|PubMed:20194617, ECO:0000269\|PubMed:23666762}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MARK2-RTN3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MARK2-RTN3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MARK2-RTN3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MARK2-RTN3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source