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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MARK3-EXOSC10 (FusionGDB2 ID:51765)

Fusion Gene Summary for MARK3-EXOSC10

check button Fusion gene summary
Fusion gene informationFusion gene name: MARK3-EXOSC10
Fusion gene ID: 51765
HgeneTgene
Gene symbol

MARK3

EXOSC10

Gene ID

4140

5394

Gene namemicrotubule affinity regulating kinase 3exosome component 10
SynonymsCTAK1|KP78|PAR1A|Par-1a|VIPBPM-Scl|PM/Scl-100|PMSCL|PMSCL2|RRP6|Rrp6p|p2|p3|p4
Cytomap

14q32.32-q32.33

1p36.22

Type of geneprotein-codingprotein-coding
DescriptionMAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78exosome component 10P100 polymyositis-scleroderma overlap syndrome-associated autoantigenautoantigen PM-SCLpolymyositis/scleroderma autoantigen 100 kDapolymyositis/scleroderma autoantigen 2
Modification date2020031320200313
UniProtAcc

P27448

Q01780

Ensembl transtripts involved in fusion geneENST00000216288, ENST00000303622, 
ENST00000335102, ENST00000416682, 
ENST00000429436, ENST00000440884, 
ENST00000553942, ENST00000561071, 
ENST00000485606, ENST00000544779, 
ENST00000304457, ENST00000376936, 
Fusion gene scores* DoF score23 X 15 X 10=345010 X 11 X 7=770
# samples 2516
** MAII scorelog2(25/3450*10)=-3.78659636189081
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/770*10)=-2.2667865406949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MARK3 [Title/Abstract] AND EXOSC10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMARK3(103928798)-EXOSC10(11137708), # samples:1
Anticipated loss of major functional domain due to fusion event.MARK3-EXOSC10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MARK3-EXOSC10 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MARK3-EXOSC10 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
MARK3-EXOSC10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMARK3

GO:0018105

peptidyl-serine phosphorylation

9543386

HgeneMARK3

GO:0032092

positive regulation of protein binding

9543386

HgeneMARK3

GO:0035331

negative regulation of hippo signaling

28087714

HgeneMARK3

GO:0036289

peptidyl-serine autophosphorylation

9543386


check buttonFusion gene breakpoints across MARK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EXOSC10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315491MARK3chr14

103928798

+EXOSC10chr1

11137708

-


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Fusion Gene ORF analysis for MARK3-EXOSC10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000216288ENST00000485606MARK3chr14

103928798

+EXOSC10chr1

11137708

-
5CDS-intronENST00000303622ENST00000485606MARK3chr14

103928798

+EXOSC10chr1

11137708

-
5CDS-intronENST00000335102ENST00000485606MARK3chr14

103928798

+EXOSC10chr1

11137708

-
5CDS-intronENST00000416682ENST00000485606MARK3chr14

103928798

+EXOSC10chr1

11137708

-
5CDS-intronENST00000429436ENST00000485606MARK3chr14

103928798

+EXOSC10chr1

11137708

-
5CDS-intronENST00000440884ENST00000485606MARK3chr14

103928798

+EXOSC10chr1

11137708

-
5CDS-intronENST00000553942ENST00000485606MARK3chr14

103928798

+EXOSC10chr1

11137708

-
Frame-shiftENST00000216288ENST00000544779MARK3chr14

103928798

+EXOSC10chr1

11137708

-
Frame-shiftENST00000303622ENST00000544779MARK3chr14

103928798

+EXOSC10chr1

11137708

-
Frame-shiftENST00000335102ENST00000544779MARK3chr14

103928798

+EXOSC10chr1

11137708

-
Frame-shiftENST00000416682ENST00000544779MARK3chr14

103928798

+EXOSC10chr1

11137708

-
Frame-shiftENST00000429436ENST00000544779MARK3chr14

103928798

+EXOSC10chr1

11137708

-
Frame-shiftENST00000440884ENST00000544779MARK3chr14

103928798

+EXOSC10chr1

11137708

-
Frame-shiftENST00000553942ENST00000544779MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000216288ENST00000304457MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000216288ENST00000376936MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000303622ENST00000304457MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000303622ENST00000376936MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000335102ENST00000304457MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000335102ENST00000376936MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000416682ENST00000304457MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000416682ENST00000376936MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000429436ENST00000304457MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000429436ENST00000376936MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000440884ENST00000304457MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000440884ENST00000376936MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000553942ENST00000304457MARK3chr14

103928798

+EXOSC10chr1

11137708

-
In-frameENST00000553942ENST00000376936MARK3chr14

103928798

+EXOSC10chr1

11137708

-
intron-3CDSENST00000561071ENST00000304457MARK3chr14

103928798

+EXOSC10chr1

11137708

-
intron-3CDSENST00000561071ENST00000376936MARK3chr14

103928798

+EXOSC10chr1

11137708

-
intron-3CDSENST00000561071ENST00000544779MARK3chr14

103928798

+EXOSC10chr1

11137708

-
intron-intronENST00000561071ENST00000485606MARK3chr14

103928798

+EXOSC10chr1

11137708

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000440884MARK3chr14103928798+ENST00000304457EXOSC10chr111137708-211211786382011457
ENST00000440884MARK3chr14103928798+ENST00000376936EXOSC10chr111137708-218711786382086482
ENST00000416682MARK3chr14103928798+ENST00000304457EXOSC10chr111137708-212011865772019480
ENST00000416682MARK3chr14103928798+ENST00000376936EXOSC10chr111137708-219511865772094505
ENST00000429436MARK3chr14103928798+ENST00000304457EXOSC10chr111137708-198410505101883457
ENST00000429436MARK3chr14103928798+ENST00000376936EXOSC10chr111137708-205910505101958482
ENST00000303622MARK3chr14103928798+ENST00000304457EXOSC10chr111137708-196310294891862457
ENST00000303622MARK3chr14103928798+ENST00000376936EXOSC10chr111137708-203810294891937482
ENST00000216288MARK3chr14103928798+ENST00000304457EXOSC10chr111137708-16447101701543457
ENST00000216288MARK3chr14103928798+ENST00000376936EXOSC10chr111137708-17197101701618482
ENST00000553942MARK3chr14103928798+ENST00000304457EXOSC10chr111137708-1519585451418457
ENST00000553942MARK3chr14103928798+ENST00000376936EXOSC10chr111137708-1594585451493482
ENST00000335102MARK3chr14103928798+ENST00000304457EXOSC10chr111137708-154360901442480
ENST00000335102MARK3chr14103928798+ENST00000376936EXOSC10chr111137708-161860901517505

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000440884ENST00000304457MARK3chr14103928798+EXOSC10chr111137708-0.005238760.9947613
ENST00000440884ENST00000376936MARK3chr14103928798+EXOSC10chr111137708-0.0065748670.99342513
ENST00000416682ENST00000304457MARK3chr14103928798+EXOSC10chr111137708-0.0063919810.993608
ENST00000416682ENST00000376936MARK3chr14103928798+EXOSC10chr111137708-0.005719230.9942808
ENST00000429436ENST00000304457MARK3chr14103928798+EXOSC10chr111137708-0.0042767730.99572325
ENST00000429436ENST00000376936MARK3chr14103928798+EXOSC10chr111137708-0.0052550840.9947449
ENST00000303622ENST00000304457MARK3chr14103928798+EXOSC10chr111137708-0.0040962860.9959038
ENST00000303622ENST00000376936MARK3chr14103928798+EXOSC10chr111137708-0.0050340780.99496585
ENST00000216288ENST00000304457MARK3chr14103928798+EXOSC10chr111137708-0.0035105010.99648947
ENST00000216288ENST00000376936MARK3chr14103928798+EXOSC10chr111137708-0.0041458090.99585426
ENST00000553942ENST00000304457MARK3chr14103928798+EXOSC10chr111137708-0.0042898040.99571013
ENST00000553942ENST00000376936MARK3chr14103928798+EXOSC10chr111137708-0.0049055150.99509454
ENST00000335102ENST00000304457MARK3chr14103928798+EXOSC10chr111137708-0.0044728210.9955272
ENST00000335102ENST00000376936MARK3chr14103928798+EXOSC10chr111137708-0.003676610.99632347

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Fusion Genomic Features for MARK3-EXOSC10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MARK3-EXOSC10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:103928798/chr1:11137708)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MARK3

P27448

EXOSC10

Q01780

FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). {ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}.FUNCTION: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA. {ECO:0000250, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMARK3chr14:103928798chr1:11137708ENST00000216288+71662_70180714.0Nucleotide bindingATP
HgeneMARK3chr14:103928798chr1:11137708ENST00000303622+71662_70180730.0Nucleotide bindingATP
HgeneMARK3chr14:103928798chr1:11137708ENST00000416682+81762_70203753.0Nucleotide bindingATP
HgeneMARK3chr14:103928798chr1:11137708ENST00000429436+71862_70180754.0Nucleotide bindingATP
HgeneMARK3chr14:103928798chr1:11137708ENST00000440884+71662_70180660.0Nucleotide bindingATP
HgeneMARK3chr14:103928798chr1:11137708ENST00000553942+71762_70180745.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMARK3chr14:103928798chr1:11137708ENST00000216288+716326_365180714.0DomainUBA
HgeneMARK3chr14:103928798chr1:11137708ENST00000216288+71656_307180714.0DomainProtein kinase
HgeneMARK3chr14:103928798chr1:11137708ENST00000216288+716704_753180714.0DomainKA1
HgeneMARK3chr14:103928798chr1:11137708ENST00000303622+716326_365180730.0DomainUBA
HgeneMARK3chr14:103928798chr1:11137708ENST00000303622+71656_307180730.0DomainProtein kinase
HgeneMARK3chr14:103928798chr1:11137708ENST00000303622+716704_753180730.0DomainKA1
HgeneMARK3chr14:103928798chr1:11137708ENST00000416682+817326_365203753.0DomainUBA
HgeneMARK3chr14:103928798chr1:11137708ENST00000416682+81756_307203753.0DomainProtein kinase
HgeneMARK3chr14:103928798chr1:11137708ENST00000416682+817704_753203753.0DomainKA1
HgeneMARK3chr14:103928798chr1:11137708ENST00000429436+718326_365180754.0DomainUBA
HgeneMARK3chr14:103928798chr1:11137708ENST00000429436+71856_307180754.0DomainProtein kinase
HgeneMARK3chr14:103928798chr1:11137708ENST00000429436+718704_753180754.0DomainKA1
HgeneMARK3chr14:103928798chr1:11137708ENST00000440884+716326_365180660.0DomainUBA
HgeneMARK3chr14:103928798chr1:11137708ENST00000440884+71656_307180660.0DomainProtein kinase
HgeneMARK3chr14:103928798chr1:11137708ENST00000440884+716704_753180660.0DomainKA1
HgeneMARK3chr14:103928798chr1:11137708ENST00000553942+717326_365180745.0DomainUBA
HgeneMARK3chr14:103928798chr1:11137708ENST00000553942+71756_307180745.0DomainProtein kinase
HgeneMARK3chr14:103928798chr1:11137708ENST00000553942+717704_753180745.0DomainKA1
TgeneEXOSC10chr14:103928798chr1:11137708ENST000003044571324503_583583861.0DomainHRDC
TgeneEXOSC10chr14:103928798chr1:11137708ENST000003769361325503_583583886.0DomainHRDC


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Fusion Gene Sequence for MARK3-EXOSC10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51765_51765_1_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000216288_EXOSC10_chr1_11137708_ENST00000304457_length(transcript)=1644nt_BP=710nt
GACGGCCCGGGCCAGGCCCGGGATCTAGACGGCCGTAGGGGGAAGGGAGCCGCCCTCCCCACGGCGCCTTTTCGGAACTGCCGTGGACTC
GAGGACGCTGGTCGCCGGCCTCCTAGGGCTGTGCTGTTTTGTTTTGACCCTCGCATTGTGCAGAATTAAAGTGCAGTAAAATGTCCACTA
GGACCCCATTGCCAACGGTGAATGAACGAGACACTGAAAACCACACGTCACATGGAGATGGGCGTCAAGAAGTTACCTCTCGTACCAGCC
GCTCAGGAGCTCGGTGTAGAAACTCTATAGCCTCCTGTGCAGATGAACAACCTCACATCGGAAACTACAGACTGTTGAAAACAATCGGCA
AGGGGAATTTTGCAAAAGTAAAATTGGCAAGACATATCCTTACAGGCAGAGAGGTTGCAATAAAAATAATTGACAAAACTCAGTTGAATC
CAACAAGTCTACAAAAGCTCTTCAGAGAAGTAAGAATAATGAAGATTTTAAATCATCCCAATATAGTGAAGTTATTCGAAGTCATTGAAA
CTGAAAAAACACTCTACCTAATCATGGAATATGCAAGTGGAGGTGAAGTATTTGACTATTTGGTTGCACATGGCAGGATGAAGGAAAAAG
AAGCAAGATCTAAATTTAGACAGATTGTGTCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGTCTGAAGTTG
CAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGTGCTGAGAGATTGGAGAATGTTCTCTTTGGACCTCACGACTGCTCCCATGCCCCTC
CGGATGGCTATCCAATCATCCCAACCAGTGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGC
TGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTG
CACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTAC
AAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAG
AACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAAC
AGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCC
AGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAAT
GCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACT
GGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATACATATTTTTAAA

>51765_51765_1_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000216288_EXOSC10_chr1_11137708_ENST00000304457_length(amino acids)=457AA_BP=180
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
SEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGP
LTVAQKKAQNIMESFENPFRMISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPR
TTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGF

--------------------------------------------------------------
>51765_51765_2_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000216288_EXOSC10_chr1_11137708_ENST00000376936_length(transcript)=1719nt_BP=710nt
GACGGCCCGGGCCAGGCCCGGGATCTAGACGGCCGTAGGGGGAAGGGAGCCGCCCTCCCCACGGCGCCTTTTCGGAACTGCCGTGGACTC
GAGGACGCTGGTCGCCGGCCTCCTAGGGCTGTGCTGTTTTGTTTTGACCCTCGCATTGTGCAGAATTAAAGTGCAGTAAAATGTCCACTA
GGACCCCATTGCCAACGGTGAATGAACGAGACACTGAAAACCACACGTCACATGGAGATGGGCGTCAAGAAGTTACCTCTCGTACCAGCC
GCTCAGGAGCTCGGTGTAGAAACTCTATAGCCTCCTGTGCAGATGAACAACCTCACATCGGAAACTACAGACTGTTGAAAACAATCGGCA
AGGGGAATTTTGCAAAAGTAAAATTGGCAAGACATATCCTTACAGGCAGAGAGGTTGCAATAAAAATAATTGACAAAACTCAGTTGAATC
CAACAAGTCTACAAAAGCTCTTCAGAGAAGTAAGAATAATGAAGATTTTAAATCATCCCAATATAGTGAAGTTATTCGAAGTCATTGAAA
CTGAAAAAACACTCTACCTAATCATGGAATATGCAAGTGGAGGTGAAGTATTTGACTATTTGGTTGCACATGGCAGGATGAAGGAAAAAG
AAGCAAGATCTAAATTTAGACAGATTGTGTCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGTCTGAAGTTG
CAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGTGCTGAGAGATTGGAGAATGTTCTCTTTGGACCTCACGACTGCTCCCATGCCCCTC
CGGATGGCTATCCAATCATCCCAACCAGTGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGC
TGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTG
CACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGTTTCTGCCCTCACTGGGACACCGTGCTCCCGTCTCTC
AGGCAGCGAAGTTCGATCCATCAACCAAAATCTATGAAATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAG
AAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCG
TCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGA
AACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGG
CTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAA
AAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGT
CCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATACATATTTTTAAACCATTAAAATTCTTC

>51765_51765_2_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000216288_EXOSC10_chr1_11137708_ENST00000376936_length(amino acids)=482AA_BP=180
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
SEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGP
LTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQ
AISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCI

--------------------------------------------------------------
>51765_51765_3_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000303622_EXOSC10_chr1_11137708_ENST00000304457_length(transcript)=1963nt_BP=1029nt
GCTCCATGGTCGGCGCCCACAGCCCGCGGCGGCCTGTCTTGCGCTCCACTTCCTTCACATCCTCCTCCGCCTCCTCGTTTTCAGGCGCCG
CCGGCGGCGCTGTGTGGAGGCCCGCGAGCTGAAATTCGCGGTGCGACGGGAGGGAGTGGAGAAGGAGGTGAGGGGGCCCAGGATCGCGGG
GCGCCCTGAGGCAAGGGGACGCCGGCGGGCCGAAGCGCAGCCCGCCGCCCGCAGGCTCGGCTCCGCCACTGCCGCCCTCCCGGTCTCCTC
GCCTCGGCCGCCGAGGCAGGGAGAGAATGAGCCCCGGGACCCGCCGGGGGACGGCCCGGGCCAGGCCCGGGATCTAGACGGCCGTAGGGG
GAAGGGAGCCGCCCTCCCCACGGCGCCTTTTCGGAACTGCCGTGGACTCGAGGACGCTGGTCGCCGGCCTCCTAGGGCTGTGCTGTTTTG
TTTTGACCCTCGCATTGTGCAGAATTAAAGTGCAGTAAAATGTCCACTAGGACCCCATTGCCAACGGTGAATGAACGAGACACTGAAAAC
CACACGTCACATGGAGATGGGCGTCAAGAAGTTACCTCTCGTACCAGCCGCTCAGGAGCTCGGTGTAGAAACTCTATAGCCTCCTGTGCA
GATGAACAACCTCACATCGGAAACTACAGACTGTTGAAAACAATCGGCAAGGGGAATTTTGCAAAAGTAAAATTGGCAAGACATATCCTT
ACAGGCAGAGAGGTTGCAATAAAAATAATTGACAAAACTCAGTTGAATCCAACAAGTCTACAAAAGCTCTTCAGAGAAGTAAGAATAATG
AAGATTTTAAATCATCCCAATATAGTGAAGTTATTCGAAGTCATTGAAACTGAAAAAACACTCTACCTAATCATGGAATATGCAAGTGGA
GGTGAAGTATTTGACTATTTGGTTGCACATGGCAGGATGAAGGAAAAAGAAGCAAGATCTAAATTTAGACAGATTGTGTCTGCAGTTCAA
TACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGTCTGAAGTTGCAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGTGCTGAG
AGATTGGAGAATGTTCTCTTTGGACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTATCCAATCATCCCAACCAGTGGATCTGTGCCA
GTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTA
TTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAAT
CCATTTAGGATGATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAG
CAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAAT
GCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCA
AAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAA
GTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAA
AGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGA

>51765_51765_3_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000303622_EXOSC10_chr1_11137708_ENST00000304457_length(amino acids)=457AA_BP=180
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
SEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGP
LTVAQKKAQNIMESFENPFRMISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPR
TTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGF

--------------------------------------------------------------
>51765_51765_4_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000303622_EXOSC10_chr1_11137708_ENST00000376936_length(transcript)=2038nt_BP=1029nt
GCTCCATGGTCGGCGCCCACAGCCCGCGGCGGCCTGTCTTGCGCTCCACTTCCTTCACATCCTCCTCCGCCTCCTCGTTTTCAGGCGCCG
CCGGCGGCGCTGTGTGGAGGCCCGCGAGCTGAAATTCGCGGTGCGACGGGAGGGAGTGGAGAAGGAGGTGAGGGGGCCCAGGATCGCGGG
GCGCCCTGAGGCAAGGGGACGCCGGCGGGCCGAAGCGCAGCCCGCCGCCCGCAGGCTCGGCTCCGCCACTGCCGCCCTCCCGGTCTCCTC
GCCTCGGCCGCCGAGGCAGGGAGAGAATGAGCCCCGGGACCCGCCGGGGGACGGCCCGGGCCAGGCCCGGGATCTAGACGGCCGTAGGGG
GAAGGGAGCCGCCCTCCCCACGGCGCCTTTTCGGAACTGCCGTGGACTCGAGGACGCTGGTCGCCGGCCTCCTAGGGCTGTGCTGTTTTG
TTTTGACCCTCGCATTGTGCAGAATTAAAGTGCAGTAAAATGTCCACTAGGACCCCATTGCCAACGGTGAATGAACGAGACACTGAAAAC
CACACGTCACATGGAGATGGGCGTCAAGAAGTTACCTCTCGTACCAGCCGCTCAGGAGCTCGGTGTAGAAACTCTATAGCCTCCTGTGCA
GATGAACAACCTCACATCGGAAACTACAGACTGTTGAAAACAATCGGCAAGGGGAATTTTGCAAAAGTAAAATTGGCAAGACATATCCTT
ACAGGCAGAGAGGTTGCAATAAAAATAATTGACAAAACTCAGTTGAATCCAACAAGTCTACAAAAGCTCTTCAGAGAAGTAAGAATAATG
AAGATTTTAAATCATCCCAATATAGTGAAGTTATTCGAAGTCATTGAAACTGAAAAAACACTCTACCTAATCATGGAATATGCAAGTGGA
GGTGAAGTATTTGACTATTTGGTTGCACATGGCAGGATGAAGGAAAAAGAAGCAAGATCTAAATTTAGACAGATTGTGTCTGCAGTTCAA
TACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGTCTGAAGTTGCAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGTGCTGAG
AGATTGGAGAATGTTCTCTTTGGACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTATCCAATCATCCCAACCAGTGGATCTGTGCCA
GTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTA
TTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAAT
CCATTTAGGATGTTTCTGCCCTCACTGGGACACCGTGCTCCCGTCTCTCAGGCAGCGAAGTTCGATCCATCAACCAAAATCTATGAAATC
AGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGG
GAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGA
GAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCA
CCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTT
GATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCA
ACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAAT

>51765_51765_4_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000303622_EXOSC10_chr1_11137708_ENST00000376936_length(amino acids)=482AA_BP=180
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
SEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGP
LTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQ
AISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCI

--------------------------------------------------------------
>51765_51765_5_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000335102_EXOSC10_chr1_11137708_ENST00000304457_length(transcript)=1543nt_BP=609nt
ATGTCCACTAGGACCCCATTGCCAACGGTGAATGAACGAGACACTGAAAACCACACGTCACATGGAGATGGGCGTCAAGAAGTTACCTCT
CGTACCAGCCGCTCAGGAGCTCGGTGTAGAAACTCTATAGCCTCCTGTGCAGATGAACAACCTCACATCGGAAACTACAGACTGTTGAAA
ACAATCGGCAAGGGGAATTTTGCAAAAGTAAAATTGGCAAGACATATCCTTACAGGCAGAGAGGTTGCAATAAAAATAATTGACAAAACT
CAGTTGAATCCAACAAGTCTACAAAAGCTCTTCAGAGAAGTAAGAATAATGAAGATTTTAAATCATCCCAATATAGTGAAGTTATTCGAA
GTCATTGAAACTGAAAAAACACTCTACCTAATCATGGAATATGCAAGTGGAGGTGAAGTATTTGACTATTTGGTTGCACATGGCAGGATG
AAGGAAAAAGAAGCAAGATCTAAATTTAGACAGGGTTGTCAAGCTGGACAGACTATTAAAGTTCAAGTCTCCTTTGATTTGCTTAGTCTG
ATGTTTACATTTATTGTGTCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGTCTGAAGTTGCAGCCGGAGTG
AAGAAGAGCGGACCGCTGCCCAGTGCTGAGAGATTGGAGAATGTTCTCTTTGGACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTAT
CCAATCATCCCAACCAGTGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACA
TGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAA
GCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCT
AAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATC
TCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAG
AAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTC
AAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCC
AAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGA
TAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATACATATTTTTAAACCATTAAAATT

>51765_51765_5_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000335102_EXOSC10_chr1_11137708_ENST00000304457_length(amino acids)=480AA_BP=203
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSL
MFTFIVSAVQYCHQKRIVHRDLKSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTT
CLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAI
SVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAA

--------------------------------------------------------------
>51765_51765_6_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000335102_EXOSC10_chr1_11137708_ENST00000376936_length(transcript)=1618nt_BP=609nt
ATGTCCACTAGGACCCCATTGCCAACGGTGAATGAACGAGACACTGAAAACCACACGTCACATGGAGATGGGCGTCAAGAAGTTACCTCT
CGTACCAGCCGCTCAGGAGCTCGGTGTAGAAACTCTATAGCCTCCTGTGCAGATGAACAACCTCACATCGGAAACTACAGACTGTTGAAA
ACAATCGGCAAGGGGAATTTTGCAAAAGTAAAATTGGCAAGACATATCCTTACAGGCAGAGAGGTTGCAATAAAAATAATTGACAAAACT
CAGTTGAATCCAACAAGTCTACAAAAGCTCTTCAGAGAAGTAAGAATAATGAAGATTTTAAATCATCCCAATATAGTGAAGTTATTCGAA
GTCATTGAAACTGAAAAAACACTCTACCTAATCATGGAATATGCAAGTGGAGGTGAAGTATTTGACTATTTGGTTGCACATGGCAGGATG
AAGGAAAAAGAAGCAAGATCTAAATTTAGACAGGGTTGTCAAGCTGGACAGACTATTAAAGTTCAAGTCTCCTTTGATTTGCTTAGTCTG
ATGTTTACATTTATTGTGTCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGTCTGAAGTTGCAGCCGGAGTG
AAGAAGAGCGGACCGCTGCCCAGTGCTGAGAGATTGGAGAATGTTCTCTTTGGACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTAT
CCAATCATCCCAACCAGTGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACA
TGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAA
GCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGTTTCTGCCCTCACTGGGACACCGTGCTCCCGTCTCTCAGGCAGCGAAG
TTCGATCCATCAACCAAAATCTATGAAATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAG
AAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAG
GTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAA
ATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGA
AACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAG
TCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACA

>51765_51765_6_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000335102_EXOSC10_chr1_11137708_ENST00000376936_length(amino acids)=505AA_BP=203
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSL
MFTFIVSAVQYCHQKRIVHRDLKSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTT
CLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVK
KKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAG

--------------------------------------------------------------
>51765_51765_7_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000416682_EXOSC10_chr1_11137708_ENST00000304457_length(transcript)=2120nt_BP=1186nt
GCAGCGGCGGCCAGCAGGGCGGAGGCTGAGGCAGCAAGCTCGCTAGAGAGGGAGAAGCAGTCGGGCGCAGGCGCCTCCTCCGCAGCCCGC
TCCATGGTCGGCGCCCACAGCCCGCGGCGGCCTGTCTTGCGCTCCACTTCCTTCACATCCTCCTCCGCCTCCTCGTTTTCAGGCGCCGCC
GGCGGCGCTGTGTGGAGGCCCGCGAGCTGAAATTCGCGGTGCGACGGGAGGGAGTGGAGAAGGAGGTGAGGGGGCCCAGGATCGCGGGGC
GCCCTGAGGCAAGGGGACGCCGGCGGGCCGAAGCGCAGCCCGCCGCCCGCAGGCTCGGCTCCGCCACTGCCGCCCTCCCGGTCTCCTCGC
CTCGGCCGCCGAGGCAGGGAGAGAATGAGCCCCGGGACCCGCCGGGGGACGGCCCGGGCCAGGCCCGGGATCTAGACGGCCGTAGGGGGA
AGGGAGCCGCCCTCCCCACGGCGCCTTTTCGGAACTGCCGTGGACTCGAGGACGCTGGTCGCCGGCCTCCTAGGGCTGTGCTGTTTTGTT
TTGACCCTCGCATTGTGCAGAATTAAAGTGCAGTAAAATGTCCACTAGGACCCCATTGCCAACGGTGAATGAACGAGACACTGAAAACCA
CACGTCACATGGAGATGGGCGTCAAGAAGTTACCTCTCGTACCAGCCGCTCAGGAGCTCGGTGTAGAAACTCTATAGCCTCCTGTGCAGA
TGAACAACCTCACATCGGAAACTACAGACTGTTGAAAACAATCGGCAAGGGGAATTTTGCAAAAGTAAAATTGGCAAGACATATCCTTAC
AGGCAGAGAGGTTGCAATAAAAATAATTGACAAAACTCAGTTGAATCCAACAAGTCTACAAAAGCTCTTCAGAGAAGTAAGAATAATGAA
GATTTTAAATCATCCCAATATAGTGAAGTTATTCGAAGTCATTGAAACTGAAAAAACACTCTACCTAATCATGGAATATGCAAGTGGAGG
TGAAGTATTTGACTATTTGGTTGCACATGGCAGGATGAAGGAAAAAGAAGCAAGATCTAAATTTAGACAGGGTTGTCAAGCTGGACAGAC
TATTAAAGTTCAAGTCTCCTTTGATTTGCTTAGTCTGATGTTTACATTTATTGTGTCTGCAGTTCAATACTGCCATCAGAAACGGATCGT
ACATCGAGACCTCAAGTCTGAAGTTGCAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGTGCTGAGAGATTGGAGAATGTTCTCTTTGG
ACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTATCCAATCATCCCAACCAGTGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTT
CCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGA
CAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGATCAGCAACCG
CTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGC
AAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGC
AACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAA
AGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAA
TAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAA
GTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGC

>51765_51765_7_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000416682_EXOSC10_chr1_11137708_ENST00000304457_length(amino acids)=480AA_BP=203
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSL
MFTFIVSAVQYCHQKRIVHRDLKSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTT
CLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAI
SVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAA

--------------------------------------------------------------
>51765_51765_8_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000416682_EXOSC10_chr1_11137708_ENST00000376936_length(transcript)=2195nt_BP=1186nt
GCAGCGGCGGCCAGCAGGGCGGAGGCTGAGGCAGCAAGCTCGCTAGAGAGGGAGAAGCAGTCGGGCGCAGGCGCCTCCTCCGCAGCCCGC
TCCATGGTCGGCGCCCACAGCCCGCGGCGGCCTGTCTTGCGCTCCACTTCCTTCACATCCTCCTCCGCCTCCTCGTTTTCAGGCGCCGCC
GGCGGCGCTGTGTGGAGGCCCGCGAGCTGAAATTCGCGGTGCGACGGGAGGGAGTGGAGAAGGAGGTGAGGGGGCCCAGGATCGCGGGGC
GCCCTGAGGCAAGGGGACGCCGGCGGGCCGAAGCGCAGCCCGCCGCCCGCAGGCTCGGCTCCGCCACTGCCGCCCTCCCGGTCTCCTCGC
CTCGGCCGCCGAGGCAGGGAGAGAATGAGCCCCGGGACCCGCCGGGGGACGGCCCGGGCCAGGCCCGGGATCTAGACGGCCGTAGGGGGA
AGGGAGCCGCCCTCCCCACGGCGCCTTTTCGGAACTGCCGTGGACTCGAGGACGCTGGTCGCCGGCCTCCTAGGGCTGTGCTGTTTTGTT
TTGACCCTCGCATTGTGCAGAATTAAAGTGCAGTAAAATGTCCACTAGGACCCCATTGCCAACGGTGAATGAACGAGACACTGAAAACCA
CACGTCACATGGAGATGGGCGTCAAGAAGTTACCTCTCGTACCAGCCGCTCAGGAGCTCGGTGTAGAAACTCTATAGCCTCCTGTGCAGA
TGAACAACCTCACATCGGAAACTACAGACTGTTGAAAACAATCGGCAAGGGGAATTTTGCAAAAGTAAAATTGGCAAGACATATCCTTAC
AGGCAGAGAGGTTGCAATAAAAATAATTGACAAAACTCAGTTGAATCCAACAAGTCTACAAAAGCTCTTCAGAGAAGTAAGAATAATGAA
GATTTTAAATCATCCCAATATAGTGAAGTTATTCGAAGTCATTGAAACTGAAAAAACACTCTACCTAATCATGGAATATGCAAGTGGAGG
TGAAGTATTTGACTATTTGGTTGCACATGGCAGGATGAAGGAAAAAGAAGCAAGATCTAAATTTAGACAGGGTTGTCAAGCTGGACAGAC
TATTAAAGTTCAAGTCTCCTTTGATTTGCTTAGTCTGATGTTTACATTTATTGTGTCTGCAGTTCAATACTGCCATCAGAAACGGATCGT
ACATCGAGACCTCAAGTCTGAAGTTGCAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGTGCTGAGAGATTGGAGAATGTTCTCTTTGG
ACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTATCCAATCATCCCAACCAGTGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTT
CCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGA
CAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGTTTCTGCCCTC
ACTGGGACACCGTGCTCCCGTCTCTCAGGCAGCGAAGTTCGATCCATCAACCAAAATCTATGAAATCAGCAACCGCTGGAAGCTGGCCCA
GGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAA
AGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAG
GACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTA
CGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTC
TGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTT
CAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATAC

>51765_51765_8_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000416682_EXOSC10_chr1_11137708_ENST00000376936_length(amino acids)=505AA_BP=203
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSL
MFTFIVSAVQYCHQKRIVHRDLKSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTT
CLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVK
KKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAG

--------------------------------------------------------------
>51765_51765_9_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000429436_EXOSC10_chr1_11137708_ENST00000304457_length(transcript)=1984nt_BP=1050nt
CAGGCGCCTCCTCCGCAGCCCGCTCCATGGTCGGCGCCCACAGCCCGCGGCGGCCTGTCTTGCGCTCCACTTCCTTCACATCCTCCTCCG
CCTCCTCGTTTTCAGGCGCCGCCGGCGGCGCTGTGTGGAGGCCCGCGAGCTGAAATTCGCGGTGCGACGGGAGGGAGTGGAGAAGGAGGT
GAGGGGGCCCAGGATCGCGGGGCGCCCTGAGGCAAGGGGACGCCGGCGGGCCGAAGCGCAGCCCGCCGCCCGCAGGCTCGGCTCCGCCAC
TGCCGCCCTCCCGGTCTCCTCGCCTCGGCCGCCGAGGCAGGGAGAGAATGAGCCCCGGGACCCGCCGGGGGACGGCCCGGGCCAGGCCCG
GGATCTAGACGGCCGTAGGGGGAAGGGAGCCGCCCTCCCCACGGCGCCTTTTCGGAACTGCCGTGGACTCGAGGACGCTGGTCGCCGGCC
TCCTAGGGCTGTGCTGTTTTGTTTTGACCCTCGCATTGTGCAGAATTAAAGTGCAGTAAAATGTCCACTAGGACCCCATTGCCAACGGTG
AATGAACGAGACACTGAAAACCACACGTCACATGGAGATGGGCGTCAAGAAGTTACCTCTCGTACCAGCCGCTCAGGAGCTCGGTGTAGA
AACTCTATAGCCTCCTGTGCAGATGAACAACCTCACATCGGAAACTACAGACTGTTGAAAACAATCGGCAAGGGGAATTTTGCAAAAGTA
AAATTGGCAAGACATATCCTTACAGGCAGAGAGGTTGCAATAAAAATAATTGACAAAACTCAGTTGAATCCAACAAGTCTACAAAAGCTC
TTCAGAGAAGTAAGAATAATGAAGATTTTAAATCATCCCAATATAGTGAAGTTATTCGAAGTCATTGAAACTGAAAAAACACTCTACCTA
ATCATGGAATATGCAAGTGGAGGTGAAGTATTTGACTATTTGGTTGCACATGGCAGGATGAAGGAAAAAGAAGCAAGATCTAAATTTAGA
CAGATTGTGTCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGTCTGAAGTTGCAGCCGGAGTGAAGAAGAGC
GGACCGCTGCCCAGTGCTGAGAGATTGGAGAATGTTCTCTTTGGACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTATCCAATCATC
CCAACCAGTGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATT
GCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAAC
ATCATGGAGTCCTTTGAAAATCCATTTAGGATGATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCT
GTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGA
CAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGA
CTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTT
GCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATT
AAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGG
AAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATACATATTTTTAAACCATTAAAATTCTTCCTGAA

>51765_51765_9_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000429436_EXOSC10_chr1_11137708_ENST00000304457_length(amino acids)=457AA_BP=180
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
SEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGP
LTVAQKKAQNIMESFENPFRMISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPR
TTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGF

--------------------------------------------------------------
>51765_51765_10_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000429436_EXOSC10_chr1_11137708_ENST00000376936_length(transcript)=2059nt_BP=1050nt
CAGGCGCCTCCTCCGCAGCCCGCTCCATGGTCGGCGCCCACAGCCCGCGGCGGCCTGTCTTGCGCTCCACTTCCTTCACATCCTCCTCCG
CCTCCTCGTTTTCAGGCGCCGCCGGCGGCGCTGTGTGGAGGCCCGCGAGCTGAAATTCGCGGTGCGACGGGAGGGAGTGGAGAAGGAGGT
GAGGGGGCCCAGGATCGCGGGGCGCCCTGAGGCAAGGGGACGCCGGCGGGCCGAAGCGCAGCCCGCCGCCCGCAGGCTCGGCTCCGCCAC
TGCCGCCCTCCCGGTCTCCTCGCCTCGGCCGCCGAGGCAGGGAGAGAATGAGCCCCGGGACCCGCCGGGGGACGGCCCGGGCCAGGCCCG
GGATCTAGACGGCCGTAGGGGGAAGGGAGCCGCCCTCCCCACGGCGCCTTTTCGGAACTGCCGTGGACTCGAGGACGCTGGTCGCCGGCC
TCCTAGGGCTGTGCTGTTTTGTTTTGACCCTCGCATTGTGCAGAATTAAAGTGCAGTAAAATGTCCACTAGGACCCCATTGCCAACGGTG
AATGAACGAGACACTGAAAACCACACGTCACATGGAGATGGGCGTCAAGAAGTTACCTCTCGTACCAGCCGCTCAGGAGCTCGGTGTAGA
AACTCTATAGCCTCCTGTGCAGATGAACAACCTCACATCGGAAACTACAGACTGTTGAAAACAATCGGCAAGGGGAATTTTGCAAAAGTA
AAATTGGCAAGACATATCCTTACAGGCAGAGAGGTTGCAATAAAAATAATTGACAAAACTCAGTTGAATCCAACAAGTCTACAAAAGCTC
TTCAGAGAAGTAAGAATAATGAAGATTTTAAATCATCCCAATATAGTGAAGTTATTCGAAGTCATTGAAACTGAAAAAACACTCTACCTA
ATCATGGAATATGCAAGTGGAGGTGAAGTATTTGACTATTTGGTTGCACATGGCAGGATGAAGGAAAAAGAAGCAAGATCTAAATTTAGA
CAGATTGTGTCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGTCTGAAGTTGCAGCCGGAGTGAAGAAGAGC
GGACCGCTGCCCAGTGCTGAGAGATTGGAGAATGTTCTCTTTGGACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTATCCAATCATC
CCAACCAGTGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATT
GCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAAC
ATCATGGAGTCCTTTGAAAATCCATTTAGGATGTTTCTGCCCTCACTGGGACACCGTGCTCCCGTCTCTCAGGCAGCGAAGTTCGATCCA
TCAACCAAAATCTATGAAATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCA
GCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTA
GAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAG
AAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAA
TCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGA
AACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCC

>51765_51765_10_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000429436_EXOSC10_chr1_11137708_ENST00000376936_length(amino acids)=482AA_BP=180
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
SEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGP
LTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQ
AISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCI

--------------------------------------------------------------
>51765_51765_11_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000440884_EXOSC10_chr1_11137708_ENST00000304457_length(transcript)=2112nt_BP=1178nt
GGAAGCCGAGGGGCGGCCATCTTGGCTCCGTGAGGCTCTGAGGTGCCGGGGTGCGGCGGCGGCAGCGGCGGCCAGCAGGGCGGAGGCTGA
GGCAGCAAGCTCGCTAGAGAGGGAGAAGCAGTCGGGCGCAGGCGCCTCCTCCGCAGCCCGCTCCATGGTCGGCGCCCACAGCCCGCGGCG
GCCTGTCTTGCGCTCCACTTCCTTCACATCCTCCTCCGCCTCCTCGTTTTCAGGCGCCGCCGGCGGCGCTGTGTGGAGGCCCGCGAGCTG
AAATTCGCGGTGCGACGGGAGGGAGTGGAGAAGGAGGTGAGGGGGCCCAGGATCGCGGGGCGCCCTGAGGCAAGGGGACGCCGGCGGGCC
GAAGCGCAGCCCGCCGCCCGCAGGCTCGGCTCCGCCACTGCCGCCCTCCCGGTCTCCTCGCCTCGGCCGCCGAGGCAGGGAGAGAATGAG
CCCCGGGACCCGCCGGGGGACGGCCCGGGCCAGGCCCGGGATCTAGACGGCCGTAGGGGGAAGGGAGCCGCCCTCCCCACGGCGCCTTTT
CGGAACTGCCGTGGACTCGAGGACGCTGGTCGCCGGCCTCCTAGGGCTGTGCTGTTTTGTTTTGACCCTCGCATTGTGCAGAATTAAAGT
GCAGTAAAATGTCCACTAGGACCCCATTGCCAACGGTGAATGAACGAGACACTGAAAACCACACGTCACATGGAGATGGGCGTCAAGAAG
TTACCTCTCGTACCAGCCGCTCAGGAGCTCGGTGTAGAAACTCTATAGCCTCCTGTGCAGATGAACAACCTCACATCGGAAACTACAGAC
TGTTGAAAACAATCGGCAAGGGGAATTTTGCAAAAGTAAAATTGGCAAGACATATCCTTACAGGCAGAGAGGTTGCAATAAAAATAATTG
ACAAAACTCAGTTGAATCCAACAAGTCTACAAAAGCTCTTCAGAGAAGTAAGAATAATGAAGATTTTAAATCATCCCAATATAGTGAAGT
TATTCGAAGTCATTGAAACTGAAAAAACACTCTACCTAATCATGGAATATGCAAGTGGAGGTGAAGTATTTGACTATTTGGTTGCACATG
GCAGGATGAAGGAAAAAGAAGCAAGATCTAAATTTAGACAGATTGTGTCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAG
ACCTCAAGTCTGAAGTTGCAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGTGCTGAGAGATTGGAGAATGTTCTCTTTGGACCTCACG
ACTGCTCCCATGCCCCTCCGGATGGCTATCCAATCATCCCAACCAGTGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATG
AAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAA
AGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGATCAGCAACCGCTGGAAGC
TGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGG
CGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCG
ACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTA
CGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGA
CCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACA
GAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTG

>51765_51765_11_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000440884_EXOSC10_chr1_11137708_ENST00000304457_length(amino acids)=457AA_BP=180
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
SEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGP
LTVAQKKAQNIMESFENPFRMISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPR
TTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGF

--------------------------------------------------------------
>51765_51765_12_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000440884_EXOSC10_chr1_11137708_ENST00000376936_length(transcript)=2187nt_BP=1178nt
GGAAGCCGAGGGGCGGCCATCTTGGCTCCGTGAGGCTCTGAGGTGCCGGGGTGCGGCGGCGGCAGCGGCGGCCAGCAGGGCGGAGGCTGA
GGCAGCAAGCTCGCTAGAGAGGGAGAAGCAGTCGGGCGCAGGCGCCTCCTCCGCAGCCCGCTCCATGGTCGGCGCCCACAGCCCGCGGCG
GCCTGTCTTGCGCTCCACTTCCTTCACATCCTCCTCCGCCTCCTCGTTTTCAGGCGCCGCCGGCGGCGCTGTGTGGAGGCCCGCGAGCTG
AAATTCGCGGTGCGACGGGAGGGAGTGGAGAAGGAGGTGAGGGGGCCCAGGATCGCGGGGCGCCCTGAGGCAAGGGGACGCCGGCGGGCC
GAAGCGCAGCCCGCCGCCCGCAGGCTCGGCTCCGCCACTGCCGCCCTCCCGGTCTCCTCGCCTCGGCCGCCGAGGCAGGGAGAGAATGAG
CCCCGGGACCCGCCGGGGGACGGCCCGGGCCAGGCCCGGGATCTAGACGGCCGTAGGGGGAAGGGAGCCGCCCTCCCCACGGCGCCTTTT
CGGAACTGCCGTGGACTCGAGGACGCTGGTCGCCGGCCTCCTAGGGCTGTGCTGTTTTGTTTTGACCCTCGCATTGTGCAGAATTAAAGT
GCAGTAAAATGTCCACTAGGACCCCATTGCCAACGGTGAATGAACGAGACACTGAAAACCACACGTCACATGGAGATGGGCGTCAAGAAG
TTACCTCTCGTACCAGCCGCTCAGGAGCTCGGTGTAGAAACTCTATAGCCTCCTGTGCAGATGAACAACCTCACATCGGAAACTACAGAC
TGTTGAAAACAATCGGCAAGGGGAATTTTGCAAAAGTAAAATTGGCAAGACATATCCTTACAGGCAGAGAGGTTGCAATAAAAATAATTG
ACAAAACTCAGTTGAATCCAACAAGTCTACAAAAGCTCTTCAGAGAAGTAAGAATAATGAAGATTTTAAATCATCCCAATATAGTGAAGT
TATTCGAAGTCATTGAAACTGAAAAAACACTCTACCTAATCATGGAATATGCAAGTGGAGGTGAAGTATTTGACTATTTGGTTGCACATG
GCAGGATGAAGGAAAAAGAAGCAAGATCTAAATTTAGACAGATTGTGTCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAG
ACCTCAAGTCTGAAGTTGCAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGTGCTGAGAGATTGGAGAATGTTCTCTTTGGACCTCACG
ACTGCTCCCATGCCCCTCCGGATGGCTATCCAATCATCCCAACCAGTGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATG
AAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAA
AGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGTTTCTGCCCTCACTGGGAC
ACCGTGCTCCCGTCTCTCAGGCAGCGAAGTTCGATCCATCAACCAAAATCTATGAAATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAG
TACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAG
CAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAG
AACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACA
GCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGA
AATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACA
ACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATACATATTTTT

>51765_51765_12_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000440884_EXOSC10_chr1_11137708_ENST00000376936_length(amino acids)=482AA_BP=180
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
SEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGP
LTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQ
AISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCI

--------------------------------------------------------------
>51765_51765_13_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000553942_EXOSC10_chr1_11137708_ENST00000304457_length(transcript)=1519nt_BP=585nt
GTTTTGTTTTGACCCTCGCATTGTGCAGAATTAAAGTGCAGTAAAATGTCCACTAGGACCCCATTGCCAACGGTGAATGAACGAGACACT
GAAAACCACACGTCACATGGAGATGGGCGTCAAGAAGTTACCTCTCGTACCAGCCGCTCAGGAGCTCGGTGTAGAAACTCTATAGCCTCC
TGTGCAGATGAACAACCTCACATCGGAAACTACAGACTGTTGAAAACAATCGGCAAGGGGAATTTTGCAAAAGTAAAATTGGCAAGACAT
ATCCTTACAGGCAGAGAGGTTGCAATAAAAATAATTGACAAAACTCAGTTGAATCCAACAAGTCTACAAAAGCTCTTCAGAGAAGTAAGA
ATAATGAAGATTTTAAATCATCCCAATATAGTGAAGTTATTCGAAGTCATTGAAACTGAAAAAACACTCTACCTAATCATGGAATATGCA
AGTGGAGGTGAAGTATTTGACTATTTGGTTGCACATGGCAGGATGAAGGAAAAAGAAGCAAGATCTAAATTTAGACAGATTGTGTCTGCA
GTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGTCTGAAGTTGCAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGT
GCTGAGAGATTGGAGAATGTTCTCTTTGGACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTATCCAATCATCCCAACCAGTGGATCT
GTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATC
ACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTT
GAAAATCCATTTAGGATGATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCA
GCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTA
GAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAG
AAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAA
TCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGA
AACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCC

>51765_51765_13_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000553942_EXOSC10_chr1_11137708_ENST00000304457_length(amino acids)=457AA_BP=180
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
SEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGP
LTVAQKKAQNIMESFENPFRMISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPR
TTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGF

--------------------------------------------------------------
>51765_51765_14_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000553942_EXOSC10_chr1_11137708_ENST00000376936_length(transcript)=1594nt_BP=585nt
GTTTTGTTTTGACCCTCGCATTGTGCAGAATTAAAGTGCAGTAAAATGTCCACTAGGACCCCATTGCCAACGGTGAATGAACGAGACACT
GAAAACCACACGTCACATGGAGATGGGCGTCAAGAAGTTACCTCTCGTACCAGCCGCTCAGGAGCTCGGTGTAGAAACTCTATAGCCTCC
TGTGCAGATGAACAACCTCACATCGGAAACTACAGACTGTTGAAAACAATCGGCAAGGGGAATTTTGCAAAAGTAAAATTGGCAAGACAT
ATCCTTACAGGCAGAGAGGTTGCAATAAAAATAATTGACAAAACTCAGTTGAATCCAACAAGTCTACAAAAGCTCTTCAGAGAAGTAAGA
ATAATGAAGATTTTAAATCATCCCAATATAGTGAAGTTATTCGAAGTCATTGAAACTGAAAAAACACTCTACCTAATCATGGAATATGCA
AGTGGAGGTGAAGTATTTGACTATTTGGTTGCACATGGCAGGATGAAGGAAAAAGAAGCAAGATCTAAATTTAGACAGATTGTGTCTGCA
GTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGTCTGAAGTTGCAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGT
GCTGAGAGATTGGAGAATGTTCTCTTTGGACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTATCCAATCATCCCAACCAGTGGATCT
GTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATC
ACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTT
GAAAATCCATTTAGGATGTTTCTGCCCTCACTGGGACACCGTGCTCCCGTCTCTCAGGCAGCGAAGTTCGATCCATCAACCAAAATCTAT
GAAATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCT
GCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAG
AAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCA
GAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCT
CAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCC
TTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCA

>51765_51765_14_MARK3-EXOSC10_MARK3_chr14_103928798_ENST00000553942_EXOSC10_chr1_11137708_ENST00000376936_length(amino acids)=482AA_BP=180
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT
QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
SEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGP
LTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQ
AISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MARK3-EXOSC10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MARK3-EXOSC10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MARK3-EXOSC10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource