FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MAST4-DYRK1B (FusionGDB2 ID:51851)

Fusion Gene Summary for MAST4-DYRK1B

check button Fusion gene summary
Fusion gene informationFusion gene name: MAST4-DYRK1B
Fusion gene ID: 51851
HgeneTgene
Gene symbol

MAST4

DYRK1B

Gene ID

375449

9149

Gene namemicrotubule associated serine/threonine kinase family member 4dual specificity tyrosine phosphorylation regulated kinase 1B
Synonyms-AOMS3|MIRK
Cytomap

5q12.3

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated serine/threonine-protein kinase 4dual specificity tyrosine-phosphorylation-regulated kinase 1Bdual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Bminibrain-related kinasemirk protein kinase
Modification date2020031320200313
UniProtAcc

O15021

Q9Y463

Ensembl transtripts involved in fusion geneENST00000261569, ENST00000403625, 
ENST00000403666, ENST00000404260, 
ENST00000405643, ENST00000406039, 
ENST00000406374, ENST00000407621, 
ENST00000478569, ENST00000490016, 
ENST00000323039, ENST00000348817, 
ENST00000430012, ENST00000593685, 
ENST00000597639, ENST00000601972, 
Fusion gene scores* DoF score15 X 13 X 8=15604 X 2 X 3=24
# samples 174
** MAII scorelog2(17/1560*10)=-3.19793937761191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAST4 [Title/Abstract] AND DYRK1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAST4(66390779)-DYRK1B(40318297), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDYRK1B

GO:0006468

protein phosphorylation

11980910

TgeneDYRK1B

GO:0045893

positive regulation of transcription, DNA-templated

11980910


check buttonFusion gene breakpoints across MAST4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DYRK1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACF123372MAST4chr5

66390779

+DYRK1Bchr19

40318297

-


Top

Fusion Gene ORF analysis for MAST4-DYRK1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000261569ENST00000323039MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000261569ENST00000348817MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000261569ENST00000430012MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000261569ENST00000593685MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000261569ENST00000597639MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000403625ENST00000323039MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000403625ENST00000348817MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000403625ENST00000430012MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000403625ENST00000593685MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000403625ENST00000597639MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000403666ENST00000323039MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000403666ENST00000348817MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000403666ENST00000430012MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000403666ENST00000593685MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000403666ENST00000597639MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000404260ENST00000323039MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000404260ENST00000348817MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000404260ENST00000430012MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000404260ENST00000593685MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000404260ENST00000597639MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000405643ENST00000323039MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000405643ENST00000348817MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000405643ENST00000430012MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000405643ENST00000593685MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000405643ENST00000597639MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000406039ENST00000323039MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000406039ENST00000348817MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000406039ENST00000430012MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000406039ENST00000593685MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000406039ENST00000597639MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000406374ENST00000323039MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000406374ENST00000348817MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000406374ENST00000430012MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000406374ENST00000593685MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000406374ENST00000597639MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000407621ENST00000323039MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000407621ENST00000348817MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000407621ENST00000430012MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000407621ENST00000593685MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000407621ENST00000597639MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000478569ENST00000323039MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000478569ENST00000348817MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000478569ENST00000430012MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000478569ENST00000593685MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000478569ENST00000597639MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000490016ENST00000323039MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000490016ENST00000348817MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000490016ENST00000430012MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000490016ENST00000593685MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-3CDSENST00000490016ENST00000597639MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-intronENST00000261569ENST00000601972MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-intronENST00000403625ENST00000601972MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-intronENST00000403666ENST00000601972MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-intronENST00000404260ENST00000601972MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-intronENST00000405643ENST00000601972MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-intronENST00000406039ENST00000601972MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-intronENST00000406374ENST00000601972MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-intronENST00000407621ENST00000601972MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-intronENST00000478569ENST00000601972MAST4chr5

66390779

+DYRK1Bchr19

40318297

-
intron-intronENST00000490016ENST00000601972MAST4chr5

66390779

+DYRK1Bchr19

40318297

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MAST4-DYRK1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MAST4-DYRK1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:66390779/:40318297)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAST4

O15021

DYRK1B

Q9Y463

FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). {ECO:0000269|PubMed:10910078, ECO:0000269|PubMed:11980910, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:24827035}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for MAST4-DYRK1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MAST4-DYRK1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MAST4-DYRK1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MAST4-DYRK1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource