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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAT2B-FBXL17 (FusionGDB2 ID:51874)

Fusion Gene Summary for MAT2B-FBXL17

check button Fusion gene summary
Fusion gene informationFusion gene name: MAT2B-FBXL17
Fusion gene ID: 51874
HgeneTgene
Gene symbol

MAT2B

FBXL17

Gene ID

27430

64839

Gene namemethionine adenosyltransferase 2BF-box and leucine rich repeat protein 17
SynonymsMAT-II|MATIIbeta|Nbla02999|SDR23E1|TGRFBXO13|Fbl17|Fbx13
Cytomap

5q34

5q21.3

Type of geneprotein-codingprotein-coding
Descriptionmethionine adenosyltransferase 2 subunit betaMAT II betabeta regulatory subunit of methionine adenosyltransferasedTDP-4-keto-6-deoxy-D-glucose 4-reductasemethionine adenosyltransferase II, betaputative dTDP-4-keto-6-deoxy-D-glucose 4-reductaseputatiF-box/LRR-repeat protein 17F-box only protein 13
Modification date2020031520200313
UniProtAcc

Q9NZL9

Q9UF56

Ensembl transtripts involved in fusion geneENST00000280969, ENST00000321757, 
ENST00000518095, ENST00000521838, 
ENST00000359660, ENST00000542267, 
ENST00000496714, 
Fusion gene scores* DoF score5 X 3 X 5=7514 X 13 X 5=910
# samples 613
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAT2B [Title/Abstract] AND FBXL17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAT2B(162939202)-FBXL17(107216880), # samples:1
Anticipated loss of major functional domain due to fusion event.MAT2B-FBXL17 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MAT2B-FBXL17 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAT2B

GO:0006556

S-adenosylmethionine biosynthetic process

10644686|25075345

TgeneFBXL17

GO:0000209

protein polyubiquitination

27234298

TgeneFBXL17

GO:0006515

protein quality control for misfolded or incompletely synthesized proteins

30190310

TgeneFBXL17

GO:0016567

protein ubiquitination

24035498|30190310

TgeneFBXL17

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

24035498|27234298

TgeneFBXL17

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

30190310


check buttonFusion gene breakpoints across MAT2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBXL17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-4986-01AMAT2Bchr5

162939202

+FBXL17chr5

107216880

-


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Fusion Gene ORF analysis for MAT2B-FBXL17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000280969ENST00000359660MAT2Bchr5

162939202

+FBXL17chr5

107216880

-
Frame-shiftENST00000280969ENST00000542267MAT2Bchr5

162939202

+FBXL17chr5

107216880

-
Frame-shiftENST00000321757ENST00000359660MAT2Bchr5

162939202

+FBXL17chr5

107216880

-
Frame-shiftENST00000321757ENST00000542267MAT2Bchr5

162939202

+FBXL17chr5

107216880

-
Frame-shiftENST00000518095ENST00000359660MAT2Bchr5

162939202

+FBXL17chr5

107216880

-
Frame-shiftENST00000518095ENST00000542267MAT2Bchr5

162939202

+FBXL17chr5

107216880

-
In-frameENST00000280969ENST00000496714MAT2Bchr5

162939202

+FBXL17chr5

107216880

-
In-frameENST00000321757ENST00000496714MAT2Bchr5

162939202

+FBXL17chr5

107216880

-
In-frameENST00000518095ENST00000496714MAT2Bchr5

162939202

+FBXL17chr5

107216880

-
intron-3CDSENST00000521838ENST00000359660MAT2Bchr5

162939202

+FBXL17chr5

107216880

-
intron-3CDSENST00000521838ENST00000496714MAT2Bchr5

162939202

+FBXL17chr5

107216880

-
intron-3CDSENST00000521838ENST00000542267MAT2Bchr5

162939202

+FBXL17chr5

107216880

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000280969MAT2Bchr5162939202+ENST00000496714FBXL17chr5107216880-344950615531936127
ENST00000321757MAT2Bchr5162939202+ENST00000496714FBXL17chr5107216880-334039742940129
ENST00000518095MAT2Bchr5162939202+ENST00000496714FBXL17chr5107216880-327433113781761127

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000280969ENST00000496714MAT2Bchr5162939202+FBXL17chr5107216880-0.0263447820.97365516
ENST00000321757ENST00000496714MAT2Bchr5162939202+FBXL17chr5107216880-0.0267068670.9732931
ENST00000518095ENST00000496714MAT2Bchr5162939202+FBXL17chr5107216880-0.0273264240.97267354

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Fusion Genomic Features for MAT2B-FBXL17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAT2B-FBXL17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:162939202/chr5:107216880)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAT2B

Q9NZL9

FBXL17

Q9UF56

FUNCTION: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}.FUNCTION: Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity). {ECO:0000250|UniProtKB:B1H1X1, ECO:0000250|UniProtKB:Q9QZN1, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:27234298, ECO:0000269|PubMed:30190310}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAT2Bchr5:162939202chr5:107216880ENST00000280969+2737_4075324.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162939202chr5:107216880ENST00000280969+2771_7275324.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162939202chr5:107216880ENST00000321757+2737_4086335.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162939202chr5:107216880ENST00000321757+2771_7286335.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162939202chr5:107216880ENST00000518095+2537_4086260.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162939202chr5:107216880ENST00000518095+2571_7286260.0Nucleotide bindingNADP
TgeneFBXL17chr5:162939202chr5:107216880ENST0000035966069216_236209304.0Compositional biasNote=Gly-rich
TgeneFBXL17chr5:162939202chr5:107216880ENST0000049671457216_236209315.0Compositional biasNote=Gly-rich
TgeneFBXL17chr5:162939202chr5:107216880ENST0000035966069318_365209304.0DomainF-box
TgeneFBXL17chr5:162939202chr5:107216880ENST0000049671457318_365209315.0DomainF-box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFBXL17chr5:162939202chr5:107216880ENST000003596606925_28209304.0Compositional biasNote=Poly-Arg
TgeneFBXL17chr5:162939202chr5:107216880ENST000003596606929_86209304.0Compositional biasNote=Pro-rich
TgeneFBXL17chr5:162939202chr5:107216880ENST000003596606990_151209304.0Compositional biasNote=Ala-rich
TgeneFBXL17chr5:162939202chr5:107216880ENST000004967145725_28209315.0Compositional biasNote=Poly-Arg
TgeneFBXL17chr5:162939202chr5:107216880ENST000004967145729_86209315.0Compositional biasNote=Pro-rich
TgeneFBXL17chr5:162939202chr5:107216880ENST000004967145790_151209315.0Compositional biasNote=Ala-rich
TgeneFBXL17chr5:162939202chr5:107216880ENST0000054226769216_236607702.0Compositional biasNote=Gly-rich
TgeneFBXL17chr5:162939202chr5:107216880ENST000005422676925_28607702.0Compositional biasNote=Poly-Arg
TgeneFBXL17chr5:162939202chr5:107216880ENST000005422676929_86607702.0Compositional biasNote=Pro-rich
TgeneFBXL17chr5:162939202chr5:107216880ENST000005422676990_151607702.0Compositional biasNote=Ala-rich
TgeneFBXL17chr5:162939202chr5:107216880ENST0000054226769318_365607702.0DomainF-box


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Fusion Gene Sequence for MAT2B-FBXL17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51874_51874_1_MAT2B-FBXL17_MAT2B_chr5_162939202_ENST00000280969_FBXL17_chr5_107216880_ENST00000496714_length(transcript)=3449nt_BP=506nt
GCAAATAGACCCAGGCTTGACTGGCAATTAAACATGAAACTTCTCATTGGGTATTTTCGAGACTACTACGGGGAATCAGCTACCAGCTTA
CTGCCATGTGGAGAACTGCACGAGATTCCGGGATTGGAATCAAAATGCTAATTTAAAAGGTCAAGTGAAGCTGCTCCTCACGTTTTGGCG
TGCCTGCGCTCTCTGCAGGCAGAAGCGAACAAAGACCCAGCAAGAGAAGGCAGAGGCTAAGACCCATCCCGTATCTGCTCTCCTGAAATA
ATTCTGGAGTCATGCCTGAAATGCCAGAGGACATGGAGCAGGAGGAAGTTAACATCCCTAATAGGAGGGTTCTGGTTACTGGTGCCACTG
GGCTTCTTGGCAGAGCTGTACACAAAGAATTTCAGCAGAATAATTGGCATGCAGTTGGCTGTGGTTTCAGAAGAGCAAGACCAAAATTTG
AACAGGTTAATCTGTTGGATTCTAATGCAGTTCATCACATCATTCATGATTTTCAGCACTGATAGCCATTGGGCGATACAGCATGACAAT
AGAGACTGTGGATGTCGGATGGTGTAAAGAAATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCAGCAAGTCTCTGAGATATTTGGG
GCTGATGAGATGTGATAAAGTAAGAGTTGACTATCAAGTTGTTTGCTTTCTACATATCAGTATAGTTAATAGCTTGATGTCATATCCTCT
CTCCTTCTCTATCTCCACCCCCGTGTATTATATATTATATATACATTTTATATGTATATATGCAATTATAGCTATGCATTGTTTGCCTGC
TTTTGTAAACTAATCTGAGATTATCTTTGTATTTCCCCACTTAATAATGAATTTTGTGCTTAAGTAGAAAGAAAAAGTAATCATATACAT
AGTCAACTAGAGTTTGGCATCCTATTCATAAGTCCATGGACCAAAATGTAAAAGATTACATGACAAACTGCAATTTGCAGGGTCTAACCG
TAAAATTGTATTCTGGGTTTCAAGTTTCCAGCAACAGTAAAGGTGGAAAGAACAGTGCCAAATTGGTTTTTCACAAGTGTGTAATTTTGG
TACTGAACATCTATGTATTCTGGCCATTCGGGACCAACAAAGGGCCAGTAAGGGGGTATGTGGGAATTTGCATCTCCCCATACATCAGAT
GCCACTCCCAGCACATGATAAGAAGTGGTTCCAGAGGTCCTGGTGGAAGGCCTGTAGAACCAGCCAGGGATGTGAGCATGAGTTTAGGAA
ATGGTGTAGCATTTAACGTGGGACCCTTTGAAGACTGAGAAAACAGATAATAAAAATCTATACTGACACCTGTAATCCCAGCACATTGGG
AGGCCAAGGCAGAAGGATCACTTGAGCCCAGGAATTTGAGACCAGCCTGGACAACATGGGAAAACCCTGTCTCTATCCCCCTCTCCCCCA
ACAAAAAAAAATTAGCCAGGCATAATGGCACACACCTGTAGTCCCAGCTACTCGGGAAGCTAAGGTGGGAGGATCACCTGAGCTCAAGAG
GCCGAGGTTGCAGTGAGCCGTGATTGTGCCGCAACCACCTCAGCCTGGATGACGGAGCACGACTGTGTCCCAAACAAACAAAAAAAACCT
ATACTGGACACCAGGCACTCCACAGGTGTTTTCTTCTTTGTTTATTCCATGTTTTACCTATAACAAGTCTAAGAAATAGTTATTTGCATT
GTGAAGGGGAGAAAATGGAGGCTCAGAAAGACCAGTCAGTGGCCCCAGGATACTCTGGCAAGACTTCATGCCGGGTCTTTGGAGTCTGTA
TCCAGTGCTGCTGGCACAACCCAGGGGGCAGTCTGTGGCCACGGGGACTGCTTCCCTTGGAAAAGGTCCAGTTCAGATACTTGCTCAGAA
AGTGCCGCCATCTTGTACTAATTTACACATGTGTGCTACTTTTGTAAATGGTGATTAGGAACAAATCTAGCAAAATAATGTGAAACTAAA
TAGACACGCCATTCAAAGGGCATGCATCTTCTAAATGTAGCAAATGTGGGGGCAAATGAAGTATGGCCCAAAGCTCTTGTGTCCTTTGTG
ATTTTTTGTTAATTGGCTAATTCTTTTCTCCAAACACTTTAGAATCCCAACTTATACGAGACCTTTGCCAGCTAGTTATGTTTAGAGAAA
TGTTATTATATATTCTCAGCCCAGCCCAGAAGCGACTTACTTTGTAACTAAGCAACAGCACTGAGATCCGGGGCTTGCGAGTCTCCCACA
AATCTTTCCACTAACCAACCTAATGCCGCTGCTAACCCTGCCACTTTAAAATGACTTCTTTTAAGACAAGTTAAAGGGTCCACCATAGGC
ATAGTCCTCTAGAAACAGGAATCAATGACAGCAGAACTCCTCAGCTTCCAGCAGAAGGAACTGCCACATGAATGCTAACTAAAGCTACCA
AAATGTACACATTCATACATATGTGTCCGCAGCCATTCTCAGAAATTGTCATATTTCTAACCTGTAATCTTTAGATGGTTAAGATCAGCT
CCATCTTCGGAGATACACTGTAGAAGTTGTATGTTACAGTTACTACAGGAGAATGTTATTCCAGACATATTTGCTGACCAGCATTTTGCT
GATTTTTAGTTAAGAAATGGGTTATTTTCTACCCAAATGCAAATTAGTCCAAAATTAAATAGAGACAGTATTCAGATTAGCTGTATCCCT
GAGGGTTTTAGCCCTTTTCCTGGGCTGCCTCTGAATCCTTTCTCTAACCAGAGAGCCACTCTGAGAACCCATTGGCTCCAGCACGACGCC
GTCTGGTCAGAGCCTGCTGCAGTGCAGCCCAGGGAGATGCTGGACCCAGCCTTGCTGTCTGGCTTCCTCAGACTTAAAGCAGCTCAGAGC
CAAACACGAGAGGCTCTGTGAGGATGGAAGACAGTTCCAAACCACACACAAAGCACAAGTAAAGCCTTGCACAGAAAAGCCTGCTTGTTG
GTTTAGTTGGATGGAAATCTAAAGTAGCTATTCAGTTTTCAGATTTTGTATCATGCCATCCATCTCCAGATTTTAAGTTACCATCAAGAT
TCAAAGGAAGATATGAGTAACAAAGAAAAGAAATTAGTAGCAACGGTATGGTCTGCGGAGAGCCAGAGTTCAGGTTCAGATCTGGGCTTT
GCACTTACTAGTTGTGTCACCGCGGGCAGTTACTAACCTCTCAGTGCCTGTTCCCTCGTTTGCAAAATGAGGATGATACTAGTACCTATC
TTGTAGAATTGTGAGCATGTGAATGAGTTAACATACATAAAGCACTTAGAATAATGTCTATTATATATAAAATGCTCTGTTACTGATTAG
TCTTATCATCCATATCATTATATTAACCTGTGTTGTGATACTGGAATTTTCCAATGAGAAAAAAAAATTATATTGCCTACTATCCCATTT

>51874_51874_1_MAT2B-FBXL17_MAT2B_chr5_162939202_ENST00000280969_FBXL17_chr5_107216880_ENST00000496714_length(amino acids)=127AA_BP=
MCRNHLSLDDGARLCPKQTKKTYTGHQALHRCFLLCLFHVLPITSLRNSYLHCEGEKMEAQKDQSVAPGYSGKTSCRVFGVCIQCCWHNP

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>51874_51874_2_MAT2B-FBXL17_MAT2B_chr5_162939202_ENST00000321757_FBXL17_chr5_107216880_ENST00000496714_length(transcript)=3340nt_BP=397nt
GCAGCGGAAGCCGGAAGCGGCGAGCGGGGTCGTTCTGGGCCTAGGGGAGGCGGGCCGAGGGCGTCTGAGCTGAGGCCCGCGTCGATCCTG
GGTTGGAGGAGGTGGCGGCCGCTGAGGCTGCGGCGTGAAGACGGCGGGCATGGTGGGGCGGGAGAAAGAGCTCTCTATACACTTTGTTCC
CGGGAGCTGTCGGCTGGTGGAGGAGGAAGTTAACATCCCTAATAGGAGGGTTCTGGTTACTGGTGCCACTGGGCTTCTTGGCAGAGCTGT
ACACAAAGAATTTCAGCAGAATAATTGGCATGCAGTTGGCTGTGGTTTCAGAAGAGCAAGACCAAAATTTGAACAGGTTAATCTGTTGGA
TTCTAATGCAGTTCATCACATCATTCATGATTTTCAGCACTGATAGCCATTGGGCGATACAGCATGACAATAGAGACTGTGGATGTCGGA
TGGTGTAAAGAAATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCAGCAAGTCTCTGAGATATTTGGGGCTGATGAGATGTGATAAA
GTAAGAGTTGACTATCAAGTTGTTTGCTTTCTACATATCAGTATAGTTAATAGCTTGATGTCATATCCTCTCTCCTTCTCTATCTCCACC
CCCGTGTATTATATATTATATATACATTTTATATGTATATATGCAATTATAGCTATGCATTGTTTGCCTGCTTTTGTAAACTAATCTGAG
ATTATCTTTGTATTTCCCCACTTAATAATGAATTTTGTGCTTAAGTAGAAAGAAAAAGTAATCATATACATAGTCAACTAGAGTTTGGCA
TCCTATTCATAAGTCCATGGACCAAAATGTAAAAGATTACATGACAAACTGCAATTTGCAGGGTCTAACCGTAAAATTGTATTCTGGGTT
TCAAGTTTCCAGCAACAGTAAAGGTGGAAAGAACAGTGCCAAATTGGTTTTTCACAAGTGTGTAATTTTGGTACTGAACATCTATGTATT
CTGGCCATTCGGGACCAACAAAGGGCCAGTAAGGGGGTATGTGGGAATTTGCATCTCCCCATACATCAGATGCCACTCCCAGCACATGAT
AAGAAGTGGTTCCAGAGGTCCTGGTGGAAGGCCTGTAGAACCAGCCAGGGATGTGAGCATGAGTTTAGGAAATGGTGTAGCATTTAACGT
GGGACCCTTTGAAGACTGAGAAAACAGATAATAAAAATCTATACTGACACCTGTAATCCCAGCACATTGGGAGGCCAAGGCAGAAGGATC
ACTTGAGCCCAGGAATTTGAGACCAGCCTGGACAACATGGGAAAACCCTGTCTCTATCCCCCTCTCCCCCAACAAAAAAAAATTAGCCAG
GCATAATGGCACACACCTGTAGTCCCAGCTACTCGGGAAGCTAAGGTGGGAGGATCACCTGAGCTCAAGAGGCCGAGGTTGCAGTGAGCC
GTGATTGTGCCGCAACCACCTCAGCCTGGATGACGGAGCACGACTGTGTCCCAAACAAACAAAAAAAACCTATACTGGACACCAGGCACT
CCACAGGTGTTTTCTTCTTTGTTTATTCCATGTTTTACCTATAACAAGTCTAAGAAATAGTTATTTGCATTGTGAAGGGGAGAAAATGGA
GGCTCAGAAAGACCAGTCAGTGGCCCCAGGATACTCTGGCAAGACTTCATGCCGGGTCTTTGGAGTCTGTATCCAGTGCTGCTGGCACAA
CCCAGGGGGCAGTCTGTGGCCACGGGGACTGCTTCCCTTGGAAAAGGTCCAGTTCAGATACTTGCTCAGAAAGTGCCGCCATCTTGTACT
AATTTACACATGTGTGCTACTTTTGTAAATGGTGATTAGGAACAAATCTAGCAAAATAATGTGAAACTAAATAGACACGCCATTCAAAGG
GCATGCATCTTCTAAATGTAGCAAATGTGGGGGCAAATGAAGTATGGCCCAAAGCTCTTGTGTCCTTTGTGATTTTTTGTTAATTGGCTA
ATTCTTTTCTCCAAACACTTTAGAATCCCAACTTATACGAGACCTTTGCCAGCTAGTTATGTTTAGAGAAATGTTATTATATATTCTCAG
CCCAGCCCAGAAGCGACTTACTTTGTAACTAAGCAACAGCACTGAGATCCGGGGCTTGCGAGTCTCCCACAAATCTTTCCACTAACCAAC
CTAATGCCGCTGCTAACCCTGCCACTTTAAAATGACTTCTTTTAAGACAAGTTAAAGGGTCCACCATAGGCATAGTCCTCTAGAAACAGG
AATCAATGACAGCAGAACTCCTCAGCTTCCAGCAGAAGGAACTGCCACATGAATGCTAACTAAAGCTACCAAAATGTACACATTCATACA
TATGTGTCCGCAGCCATTCTCAGAAATTGTCATATTTCTAACCTGTAATCTTTAGATGGTTAAGATCAGCTCCATCTTCGGAGATACACT
GTAGAAGTTGTATGTTACAGTTACTACAGGAGAATGTTATTCCAGACATATTTGCTGACCAGCATTTTGCTGATTTTTAGTTAAGAAATG
GGTTATTTTCTACCCAAATGCAAATTAGTCCAAAATTAAATAGAGACAGTATTCAGATTAGCTGTATCCCTGAGGGTTTTAGCCCTTTTC
CTGGGCTGCCTCTGAATCCTTTCTCTAACCAGAGAGCCACTCTGAGAACCCATTGGCTCCAGCACGACGCCGTCTGGTCAGAGCCTGCTG
CAGTGCAGCCCAGGGAGATGCTGGACCCAGCCTTGCTGTCTGGCTTCCTCAGACTTAAAGCAGCTCAGAGCCAAACACGAGAGGCTCTGT
GAGGATGGAAGACAGTTCCAAACCACACACAAAGCACAAGTAAAGCCTTGCACAGAAAAGCCTGCTTGTTGGTTTAGTTGGATGGAAATC
TAAAGTAGCTATTCAGTTTTCAGATTTTGTATCATGCCATCCATCTCCAGATTTTAAGTTACCATCAAGATTCAAAGGAAGATATGAGTA
ACAAAGAAAAGAAATTAGTAGCAACGGTATGGTCTGCGGAGAGCCAGAGTTCAGGTTCAGATCTGGGCTTTGCACTTACTAGTTGTGTCA
CCGCGGGCAGTTACTAACCTCTCAGTGCCTGTTCCCTCGTTTGCAAAATGAGGATGATACTAGTACCTATCTTGTAGAATTGTGAGCATG
TGAATGAGTTAACATACATAAAGCACTTAGAATAATGTCTATTATATATAAAATGCTCTGTTACTGATTAGTCTTATCATCCATATCATT
ATATTAACCTGTGTTGTGATACTGGAATTTTCCAATGAGAAAAAAAAATTATATTGCCTACTATCCCATTTTGAAAGACAATTAAAAAGA

>51874_51874_2_MAT2B-FBXL17_MAT2B_chr5_162939202_ENST00000321757_FBXL17_chr5_107216880_ENST00000496714_length(amino acids)=129AA_BP=
MSCCIAQWLSVLKIMNDVMNCIRIQQINLFKFWSCSSETTANCMPIILLKFFVYSSAKKPSGTSNQNPPIRDVNFLLHQPTAPGNKVYRE

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>51874_51874_3_MAT2B-FBXL17_MAT2B_chr5_162939202_ENST00000518095_FBXL17_chr5_107216880_ENST00000496714_length(transcript)=3274nt_BP=331nt
GAGCTGAGGCCCGCGTCGATCCTGGGTTGGAGGAGGTGGCGGCCGCTGAGGCTGCGGCGTGAAGACGGCGGGCATGGTGGGGCGGGAGAA
AGAGCTCTCTATACACTTTGTTCCCGGGAGCTGTCGGCTGGTGGAGGAGGAAGTTAACATCCCTAATAGGAGGGTTCTGGTTACTGGTGC
CACTGGGCTTCTTGGCAGAGCTGTACACAAAGAATTTCAGCAGAATAATTGGCATGCAGTTGGCTGTGGTTTCAGAAGAGCAAGACCAAA
ATTTGAACAGGTTAATCTGTTGGATTCTAATGCAGTTCATCACATCATTCATGATTTTCAGCACTGATAGCCATTGGGCGATACAGCATG
ACAATAGAGACTGTGGATGTCGGATGGTGTAAAGAAATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCAGCAAGTCTCTGAGATAT
TTGGGGCTGATGAGATGTGATAAAGTAAGAGTTGACTATCAAGTTGTTTGCTTTCTACATATCAGTATAGTTAATAGCTTGATGTCATAT
CCTCTCTCCTTCTCTATCTCCACCCCCGTGTATTATATATTATATATACATTTTATATGTATATATGCAATTATAGCTATGCATTGTTTG
CCTGCTTTTGTAAACTAATCTGAGATTATCTTTGTATTTCCCCACTTAATAATGAATTTTGTGCTTAAGTAGAAAGAAAAAGTAATCATA
TACATAGTCAACTAGAGTTTGGCATCCTATTCATAAGTCCATGGACCAAAATGTAAAAGATTACATGACAAACTGCAATTTGCAGGGTCT
AACCGTAAAATTGTATTCTGGGTTTCAAGTTTCCAGCAACAGTAAAGGTGGAAAGAACAGTGCCAAATTGGTTTTTCACAAGTGTGTAAT
TTTGGTACTGAACATCTATGTATTCTGGCCATTCGGGACCAACAAAGGGCCAGTAAGGGGGTATGTGGGAATTTGCATCTCCCCATACAT
CAGATGCCACTCCCAGCACATGATAAGAAGTGGTTCCAGAGGTCCTGGTGGAAGGCCTGTAGAACCAGCCAGGGATGTGAGCATGAGTTT
AGGAAATGGTGTAGCATTTAACGTGGGACCCTTTGAAGACTGAGAAAACAGATAATAAAAATCTATACTGACACCTGTAATCCCAGCACA
TTGGGAGGCCAAGGCAGAAGGATCACTTGAGCCCAGGAATTTGAGACCAGCCTGGACAACATGGGAAAACCCTGTCTCTATCCCCCTCTC
CCCCAACAAAAAAAAATTAGCCAGGCATAATGGCACACACCTGTAGTCCCAGCTACTCGGGAAGCTAAGGTGGGAGGATCACCTGAGCTC
AAGAGGCCGAGGTTGCAGTGAGCCGTGATTGTGCCGCAACCACCTCAGCCTGGATGACGGAGCACGACTGTGTCCCAAACAAACAAAAAA
AACCTATACTGGACACCAGGCACTCCACAGGTGTTTTCTTCTTTGTTTATTCCATGTTTTACCTATAACAAGTCTAAGAAATAGTTATTT
GCATTGTGAAGGGGAGAAAATGGAGGCTCAGAAAGACCAGTCAGTGGCCCCAGGATACTCTGGCAAGACTTCATGCCGGGTCTTTGGAGT
CTGTATCCAGTGCTGCTGGCACAACCCAGGGGGCAGTCTGTGGCCACGGGGACTGCTTCCCTTGGAAAAGGTCCAGTTCAGATACTTGCT
CAGAAAGTGCCGCCATCTTGTACTAATTTACACATGTGTGCTACTTTTGTAAATGGTGATTAGGAACAAATCTAGCAAAATAATGTGAAA
CTAAATAGACACGCCATTCAAAGGGCATGCATCTTCTAAATGTAGCAAATGTGGGGGCAAATGAAGTATGGCCCAAAGCTCTTGTGTCCT
TTGTGATTTTTTGTTAATTGGCTAATTCTTTTCTCCAAACACTTTAGAATCCCAACTTATACGAGACCTTTGCCAGCTAGTTATGTTTAG
AGAAATGTTATTATATATTCTCAGCCCAGCCCAGAAGCGACTTACTTTGTAACTAAGCAACAGCACTGAGATCCGGGGCTTGCGAGTCTC
CCACAAATCTTTCCACTAACCAACCTAATGCCGCTGCTAACCCTGCCACTTTAAAATGACTTCTTTTAAGACAAGTTAAAGGGTCCACCA
TAGGCATAGTCCTCTAGAAACAGGAATCAATGACAGCAGAACTCCTCAGCTTCCAGCAGAAGGAACTGCCACATGAATGCTAACTAAAGC
TACCAAAATGTACACATTCATACATATGTGTCCGCAGCCATTCTCAGAAATTGTCATATTTCTAACCTGTAATCTTTAGATGGTTAAGAT
CAGCTCCATCTTCGGAGATACACTGTAGAAGTTGTATGTTACAGTTACTACAGGAGAATGTTATTCCAGACATATTTGCTGACCAGCATT
TTGCTGATTTTTAGTTAAGAAATGGGTTATTTTCTACCCAAATGCAAATTAGTCCAAAATTAAATAGAGACAGTATTCAGATTAGCTGTA
TCCCTGAGGGTTTTAGCCCTTTTCCTGGGCTGCCTCTGAATCCTTTCTCTAACCAGAGAGCCACTCTGAGAACCCATTGGCTCCAGCACG
ACGCCGTCTGGTCAGAGCCTGCTGCAGTGCAGCCCAGGGAGATGCTGGACCCAGCCTTGCTGTCTGGCTTCCTCAGACTTAAAGCAGCTC
AGAGCCAAACACGAGAGGCTCTGTGAGGATGGAAGACAGTTCCAAACCACACACAAAGCACAAGTAAAGCCTTGCACAGAAAAGCCTGCT
TGTTGGTTTAGTTGGATGGAAATCTAAAGTAGCTATTCAGTTTTCAGATTTTGTATCATGCCATCCATCTCCAGATTTTAAGTTACCATC
AAGATTCAAAGGAAGATATGAGTAACAAAGAAAAGAAATTAGTAGCAACGGTATGGTCTGCGGAGAGCCAGAGTTCAGGTTCAGATCTGG
GCTTTGCACTTACTAGTTGTGTCACCGCGGGCAGTTACTAACCTCTCAGTGCCTGTTCCCTCGTTTGCAAAATGAGGATGATACTAGTAC
CTATCTTGTAGAATTGTGAGCATGTGAATGAGTTAACATACATAAAGCACTTAGAATAATGTCTATTATATATAAAATGCTCTGTTACTG
ATTAGTCTTATCATCCATATCATTATATTAACCTGTGTTGTGATACTGGAATTTTCCAATGAGAAAAAAAAATTATATTGCCTACTATCC

>51874_51874_3_MAT2B-FBXL17_MAT2B_chr5_162939202_ENST00000518095_FBXL17_chr5_107216880_ENST00000496714_length(amino acids)=127AA_BP=
MCRNHLSLDDGARLCPKQTKKTYTGHQALHRCFLLCLFHVLPITSLRNSYLHCEGEKMEAQKDQSVAPGYSGKTSCRVFGVCIQCCWHNP

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Fusion Gene PPI Analysis for MAT2B-FBXL17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAT2B-FBXL17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAT2B-FBXL17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource