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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAT2B-LARS (FusionGDB2 ID:51875)

Fusion Gene Summary for MAT2B-LARS

check button Fusion gene summary
Fusion gene informationFusion gene name: MAT2B-LARS
Fusion gene ID: 51875
HgeneTgene
Gene symbol

MAT2B

LARS

Gene ID

27430

51520

Gene namemethionine adenosyltransferase 2Bleucyl-tRNA synthetase 1
SynonymsMAT-II|MATIIbeta|Nbla02999|SDR23E1|TGRHSPC192|ILFS1|LARS|LEURS|LEUS|LFIS|LRS|PIG44|RNTLS|hr025Cl
Cytomap

5q34

5q32

Type of geneprotein-codingprotein-coding
Descriptionmethionine adenosyltransferase 2 subunit betaMAT II betabeta regulatory subunit of methionine adenosyltransferasedTDP-4-keto-6-deoxy-D-glucose 4-reductasemethionine adenosyltransferase II, betaputative dTDP-4-keto-6-deoxy-D-glucose 4-reductaseputatileucine--tRNA ligase, cytoplasmiccytoplasmic leucyl-tRNA synthetasecytosolic leucyl-tRNA synthetaseleucine tRNA ligase 1, cytoplasmicleucine translaseproliferation-inducing gene 44
Modification date2020031520200313
UniProtAcc

Q9NZL9

Q15031

Ensembl transtripts involved in fusion geneENST00000321757, ENST00000518095, 
ENST00000280969, ENST00000521838, 
ENST00000511505, ENST00000510191, 
ENST00000274562, ENST00000394434, 
ENST00000545646, 
Fusion gene scores* DoF score5 X 3 X 5=7510 X 8 X 6=480
# samples 610
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAT2B [Title/Abstract] AND LARS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAT2B(162932755)-LARS(145557228), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAT2B

GO:0006556

S-adenosylmethionine biosynthetic process

10644686|25075345

TgeneLARS

GO:0006425

glutaminyl-tRNA aminoacylation

26869582


check buttonFusion gene breakpoints across MAT2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LARS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-8238-01AMAT2Bchr5

162932755

+LARSchr5

145557228

-


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Fusion Gene ORF analysis for MAT2B-LARS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000321757ENST00000511505MAT2Bchr5

162932755

+LARSchr5

145557228

-
5CDS-5UTRENST00000518095ENST00000511505MAT2Bchr5

162932755

+LARSchr5

145557228

-
5CDS-intronENST00000321757ENST00000510191MAT2Bchr5

162932755

+LARSchr5

145557228

-
5CDS-intronENST00000518095ENST00000510191MAT2Bchr5

162932755

+LARSchr5

145557228

-
In-frameENST00000321757ENST00000274562MAT2Bchr5

162932755

+LARSchr5

145557228

-
In-frameENST00000321757ENST00000394434MAT2Bchr5

162932755

+LARSchr5

145557228

-
In-frameENST00000321757ENST00000545646MAT2Bchr5

162932755

+LARSchr5

145557228

-
In-frameENST00000518095ENST00000274562MAT2Bchr5

162932755

+LARSchr5

145557228

-
In-frameENST00000518095ENST00000394434MAT2Bchr5

162932755

+LARSchr5

145557228

-
In-frameENST00000518095ENST00000545646MAT2Bchr5

162932755

+LARSchr5

145557228

-
intron-3CDSENST00000280969ENST00000274562MAT2Bchr5

162932755

+LARSchr5

145557228

-
intron-3CDSENST00000280969ENST00000394434MAT2Bchr5

162932755

+LARSchr5

145557228

-
intron-3CDSENST00000280969ENST00000545646MAT2Bchr5

162932755

+LARSchr5

145557228

-
intron-3CDSENST00000521838ENST00000274562MAT2Bchr5

162932755

+LARSchr5

145557228

-
intron-3CDSENST00000521838ENST00000394434MAT2Bchr5

162932755

+LARSchr5

145557228

-
intron-3CDSENST00000521838ENST00000545646MAT2Bchr5

162932755

+LARSchr5

145557228

-
intron-5UTRENST00000280969ENST00000511505MAT2Bchr5

162932755

+LARSchr5

145557228

-
intron-5UTRENST00000521838ENST00000511505MAT2Bchr5

162932755

+LARSchr5

145557228

-
intron-intronENST00000280969ENST00000510191MAT2Bchr5

162932755

+LARSchr5

145557228

-
intron-intronENST00000521838ENST00000510191MAT2Bchr5

162932755

+LARSchr5

145557228

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321757MAT2Bchr5162932755+ENST00000394434LARSchr5145557228-479520213937261195
ENST00000321757MAT2Bchr5162932755+ENST00000545646LARSchr5145557228-385220213935881149
ENST00000321757MAT2Bchr5162932755+ENST00000274562LARSchr5145557228-384120213936451168
ENST00000518095MAT2Bchr5162932755+ENST00000394434LARSchr5145557228-47291367336601195
ENST00000518095MAT2Bchr5162932755+ENST00000545646LARSchr5145557228-37861367335221149
ENST00000518095MAT2Bchr5162932755+ENST00000274562LARSchr5145557228-37751367335791168

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321757ENST00000394434MAT2Bchr5162932755+LARSchr5145557228-0.0002092760.9997907
ENST00000321757ENST00000545646MAT2Bchr5162932755+LARSchr5145557228-0.0003332280.9996668
ENST00000321757ENST00000274562MAT2Bchr5162932755+LARSchr5145557228-0.000353430.99964654
ENST00000518095ENST00000394434MAT2Bchr5162932755+LARSchr5145557228-0.0001921370.9998079
ENST00000518095ENST00000545646MAT2Bchr5162932755+LARSchr5145557228-0.0003067390.9996933
ENST00000518095ENST00000274562MAT2Bchr5162932755+LARSchr5145557228-0.000324610.9996754

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Fusion Genomic Features for MAT2B-LARS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAT2B-LARS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:162932755/chr5:145557228)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAT2B

Q9NZL9

LARS

Q15031

FUNCTION: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLARSchr5:162932755chr5:145557228ENST0000039443403253_6321177.0MotifNote='HIGH' region
TgeneLARSchr5:162932755chr5:145557228ENST00000394434032716_72021177.0MotifNote='KMSKS' region
TgeneLARSchr5:162932755chr5:145557228ENST00000394434032260_50921177.0RegionNote=Editing domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAT2Bchr5:162932755chr5:145557228ENST00000280969+1737_400324.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162932755chr5:145557228ENST00000280969+1771_720324.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162932755chr5:145557228ENST00000321757+1737_4021335.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162932755chr5:145557228ENST00000321757+1771_7221335.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162932755chr5:145557228ENST00000518095+1537_4021260.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162932755chr5:145557228ENST00000518095+1571_7221260.0Nucleotide bindingNADP


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Fusion Gene Sequence for MAT2B-LARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51875_51875_1_MAT2B-LARS_MAT2B_chr5_162932755_ENST00000321757_LARS_chr5_145557228_ENST00000274562_length(transcript)=3841nt_BP=202nt
GCAGCGGAAGCCGGAAGCGGCGAGCGGGGTCGTTCTGGGCCTAGGGGAGGCGGGCCGAGGGCGTCTGAGCTGAGGCCCGCGTCGATCCTG
GGTTGGAGGAGGTGGCGGCCGCTGAGGCTGCGGCGTGAAGACGGCGGGCATGGTGGGGCGGGAGAAAGAGCTCTCTATACACTTTGTTCC
CGGGAGCTGTCGGCTGGTGGAGGAAAGAAAAGGAACAGCCAAAGTGGACTTTTTGAAGAAGATTGAGAAAGAAATCCAACAGAAATGGGA
TACTGAGAGAGTGTTTGAGGTCAATGCATCTAATTTAGAGAAACAGACCAGCAAGGGCAAGTATTTTGTAACCTTCCCATATCCATATAT
GAATGGACGCCTTCATTTGGGACACACGTTTTCTTTATCCAAATGTGAGGCATGTGCTGATAAGTTGAAAAGAGAAATAGAGCTGTATGG
TTGCCCCCCTGATTTTCCAGATGAAGAAGAGGAAGAGGAAGAAACCAGTGTTAAAACAGAAGATATAATAATTAAGGATAAAGCTAAAGG
AAAAAAGAGTAAAGCTGCTGCTAAAGCTGGATCTTCTAAATACCAGTGGGGCATTATGAAATCCCTTGGCCTGTCTGATGAAGAGATAGT
AAAATTTTCTGAAGCAGAACATTGGCTTGATTATTTCCCGCCACTGGCTATTCAGGATTTAAAAAGAATGGGTTTGAAGGTAGACTGGCG
TCGTTCCTTCATCACCACTGATGTTAATCCTTACTATGATTCATTTGTCAGATGGCAATTTTTAACATTAAGAGAAAGAAACAAAATTAA
ATTTGGGAAGCGGTATACAATTTACTCTCCGAAAGATGGACAGCCTTGCATGGATCATGATAGACAAACTGGAGAGGGTGTTGGACCTCA
GGAATATACTTTACTCAAATTGAAGGTGCTTGAGCCATACCCATCTAAATTAAGTGGCCTGAAAGGTAAAAATATTTTCTTGGTGGCTGC
TACTCTCAGACCTGAGACCATGTTTGGGCAGACAAATTGTTGGGTTCGTCCTGATATGAAGTACATTGGATTTGAGACGGTGAATGGTGA
TATATTCATCTGTACCCAAAAAGCAGCCAGGAATATGTCATACCAGGGCTTTACCAAAGACAATGGCGTGGTGCCTGTTGTTAAGGAATT
AATGGGGGAGGAAATTCTTGGTGCATCACTTTCTGCACCTTTAACATCATACAAGGTGATCTATGTTCTCCCAATGCTAACTATTAAGGA
GGATAAAGGCACTGGTGTGGTTACAAGTGTTCCTTCCGACTCCCCTGATGATATTGCTGCCCTCAGAGACTTGAAGAAAAAGCAAGCCTT
ACGAGCAAAATATGGAATTAGAGATGACATGGTCTTGCCATTTGAGCCGGTGCCAGTCATTGAAATCCCAGGTTTTGGAAATCTTTCTGC
TGTAACCATTTGTGATGAGTTGAAAATTCAGAGCCAGAATGACCGGGAAAAACTTGCAGAAGCAAAGGAGAAGATATATCTAAAAGGATT
TTATGAGGGTATCATGTTGGTGGATGGATTTAAAGGACAGAAGGTTCAAGATGTAAAGAAGACTATTCAGAAAAAGATGATTGACGCTGG
AGATGCACTTATTTACATGGAACCAGAGAAACAAGTGATGTCCAGGTCGTCAGATGAATGTGTTGTGGCTCTGTGTGACCAGTGGTACTT
GGATTATGGAGAAGAGAATTGGAAGAAACAGACATCTCAGTGCTTGAAGAACCTGGAAACATTCTGTGAGGAGACCAGGAGGAATTTTGA
AGCCACCTTAGGTTGGCTACAAGAACATGCTTGCTCAAGAACTTATGGTCTAGGCACTCACCTGCCTTGGGATGAGCAGTGGCTGATTGA
ATCACTTTCTGACTCCACTATTTACATGGCATTTTACACAGTTGCACACCTATTGCAGGGGGGTAACTTGCATGGACAGGCAGAGTCTCC
GCTGGGCATTAGACCGCAACAGATGACCAAGGAAGTTTGGGATTATGTTTTCTTCAAGGAGGCTCCATTTCCTAAGACTCAGATTGCAAA
GGAAAAATTAGATCAGTTAAAGCAGGAGTTTGAATTCTGGTATCCTGTTGATCTTCGCGTCTCTGGCAAGGATCTTGTTCCAAATCATCT
TTCATATTACCTTTATAATCATGTGGCTATGTGGCCGGAACAAAGTGACAAATGGCCTACAGCTGTGAGAGCAAATGGACATCTCCTCCT
GAACTCTGAGAAGATGTCAAAATCCACAGGCAACTTCCTCACTTTGACCCAAGCTATTGACAAATTTTCAGCAGATGGAATGCGTTTGGC
TCTGGCTGATGCTGGTGACACTGTAGAAGATGCCAACTTTGTGGAAGCCATGGCAGATGCAGGTATTCTCCGTCTGTACACCTGGGTAGA
GTGGGTGAAAGAAATGGTTGCCAACTGGGACAGCCTAAGAAGTGGTCCTGCCAGCACTTTCAATGATAGAGTTTTTGCCAGTGAATTGAA
TGCAGGAATTATAAAAACAGATCAAAACTATGAAAAGATGATGTTTAAAGAAGCTTTGAAAACAGGGTTTTTTGAGTTTCAGGCCGCAAA
AGATAAGTACCGTGAATTGGCTGTGGAAGGGATGCACAGAGAACTTGTGTTCCGGTTTATTGAAGTTCAGACACTTCTCCTCGCTCCATT
CTGTCCACATTTGTGTGAGCACATCTGGACACTCCTGGGAAAGCCTGACTCAATTATGAATGCTTCATGGCCTGTGGCAGGTCCTGTTAA
TGAAGTTTTAATACACTCCTCACAGTATCTTATGGAAGTAACACATGACCTTAGACTACGACTCAAGAACTATATGATGCCAGCTAAAGG
GAAGAAGACTGACAAACAACCCCTGCAGAAGCCCTCACATTGCACCATCTATGTGGCAAAGAACTATCCACCTTGGCAACATACCACCCT
GTCTGTTCTACGTAAACACTTTGAGGCCAATAACGGAAAACTGCCTGACAACAAAGTCATTGCTAGTGAACTAGGCAGTATGCCAGAACT
GAAGAAATACATGAAGAAAGTCATGCCATTTGTTGCCATGATTAAGGAAAATCTGGAGAAGATGGGGCCTCGTATTCTGGATTTGCAATT
AGAATTTGATGAAAAGGCTGTGCTTATGGAGAATATAGTCTATCTGACTAATTCGCTTGAGCTAGAACACATAGAAGTCAAGTTTGCCTC
CGAAGCAGAAGATAAAATCAGGGAAGACTGCTGTCCTGGGAAACCACTTAATGTTTTTAGAATAGAACCTGGTGTGTCCGTTTCTCTGGT
GAATCCCCAGCCATCCAATGGCCACTTCTCAACCAAAATTGAAATCAGGCAAGGAGATAACTGTGATTCCATAATCAGGCGTTTAATGAA
AATGAATCGAGGAATTAAAGACCTTTCCAAAGTGAAACTGATGAGATTTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGG
AAAGGAGTACACCGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGG
GATAAGGGTGGATATTGGCGATACAATAATCTATCTGGTTCATTAAACTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTA
CTACTCTGATTGTGTCTACTGATTGGCTATCAGAACCTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATG

>51875_51875_1_MAT2B-LARS_MAT2B_chr5_162932755_ENST00000321757_LARS_chr5_145557228_ENST00000274562_length(amino acids)=1168AA_BP=21
MVGREKELSIHFVPGSCRLVEERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCE
ACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLA
IQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSK
LSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTS
YKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDRE
KLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLK
NLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYV
FFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLT
QAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFK
EALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHD
LRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKE
NLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIR

--------------------------------------------------------------
>51875_51875_2_MAT2B-LARS_MAT2B_chr5_162932755_ENST00000321757_LARS_chr5_145557228_ENST00000394434_length(transcript)=4795nt_BP=202nt
GCAGCGGAAGCCGGAAGCGGCGAGCGGGGTCGTTCTGGGCCTAGGGGAGGCGGGCCGAGGGCGTCTGAGCTGAGGCCCGCGTCGATCCTG
GGTTGGAGGAGGTGGCGGCCGCTGAGGCTGCGGCGTGAAGACGGCGGGCATGGTGGGGCGGGAGAAAGAGCTCTCTATACACTTTGTTCC
CGGGAGCTGTCGGCTGGTGGAGGAAAGAAAAGGAACAGCCAAAGTGGACTTTTTGAAGAAGATTGAGAAAGAAATCCAACAGAAATGGGA
TACTGAGAGAGTGTTTGAGGTCAATGCATCTAATTTAGAGAAACAGACCAGCAAGGGCAAGTATTTTGTAACCTTCCCATATCCATATAT
GAATGGACGCCTTCATTTGGGACACACGTTTTCTTTATCCAAATGTGAGTTTGCTGTAGGGTACCAGCGATTGAAAGGAAAATGTTGTCT
GTTTCCCTTTGGCCTGCACTGTACTGGAATGCCTATTAAGGCATGTGCTGATAAGTTGAAAAGAGAAATAGAGCTGTATGGTTGCCCCCC
TGATTTTCCAGATGAAGAAGAGGAAGAGGAAGAAACCAGTGTTAAAACAGAAGATATAATAATTAAGGATAAAGCTAAAGGAAAAAAGAG
TAAAGCTGCTGCTAAAGCTGGATCTTCTAAATACCAGTGGGGCATTATGAAATCCCTTGGCCTGTCTGATGAAGAGATAGTAAAATTTTC
TGAAGCAGAACATTGGCTTGATTATTTCCCGCCACTGGCTATTCAGGATTTAAAAAGAATGGGTTTGAAGGTAGACTGGCGTCGTTCCTT
CATCACCACTGATGTTAATCCTTACTATGATTCATTTGTCAGATGGCAATTTTTAACATTAAGAGAAAGAAACAAAATTAAATTTGGGAA
GCGGTATACAATTTACTCTCCGAAAGATGGACAGCCTTGCATGGATCATGATAGACAAACTGGAGAGGGTGTTGGACCTCAGGAATATAC
TTTACTCAAATTGAAGGTGCTTGAGCCATACCCATCTAAATTAAGTGGCCTGAAAGGTAAAAATATTTTCTTGGTGGCTGCTACTCTCAG
ACCTGAGACCATGTTTGGGCAGACAAATTGTTGGGTTCGTCCTGATATGAAGTACATTGGATTTGAGACGGTGAATGGTGATATATTCAT
CTGTACCCAAAAAGCAGCCAGGAATATGTCATACCAGGGCTTTACCAAAGACAATGGCGTGGTGCCTGTTGTTAAGGAATTAATGGGGGA
GGAAATTCTTGGTGCATCACTTTCTGCACCTTTAACATCATACAAGGTGATCTATGTTCTCCCAATGCTAACTATTAAGGAGGATAAAGG
CACTGGTGTGGTTACAAGTGTTCCTTCCGACTCCCCTGATGATATTGCTGCCCTCAGAGACTTGAAGAAAAAGCAAGCCTTACGAGCAAA
ATATGGAATTAGAGATGACATGGTCTTGCCATTTGAGCCGGTGCCAGTCATTGAAATCCCAGGTTTTGGAAATCTTTCTGCTGTAACCAT
TTGTGATGAGTTGAAAATTCAGAGCCAGAATGACCGGGAAAAACTTGCAGAAGCAAAGGAGAAGATATATCTAAAAGGATTTTATGAGGG
TATCATGTTGGTGGATGGATTTAAAGGACAGAAGGTTCAAGATGTAAAGAAGACTATTCAGAAAAAGATGATTGACGCTGGAGATGCACT
TATTTACATGGAACCAGAGAAACAAGTGATGTCCAGGTCGTCAGATGAATGTGTTGTGGCTCTGTGTGACCAGTGGTACTTGGATTATGG
AGAAGAGAATTGGAAGAAACAGACATCTCAGTGCTTGAAGAACCTGGAAACATTCTGTGAGGAGACCAGGAGGAATTTTGAAGCCACCTT
AGGTTGGCTACAAGAACATGCTTGCTCAAGAACTTATGGTCTAGGCACTCACCTGCCTTGGGATGAGCAGTGGCTGATTGAATCACTTTC
TGACTCCACTATTTACATGGCATTTTACACAGTTGCACACCTATTGCAGGGGGGTAACTTGCATGGACAGGCAGAGTCTCCGCTGGGCAT
TAGACCGCAACAGATGACCAAGGAAGTTTGGGATTATGTTTTCTTCAAGGAGGCTCCATTTCCTAAGACTCAGATTGCAAAGGAAAAATT
AGATCAGTTAAAGCAGGAGTTTGAATTCTGGTATCCTGTTGATCTTCGCGTCTCTGGCAAGGATCTTGTTCCAAATCATCTTTCATATTA
CCTTTATAATCATGTGGCTATGTGGCCGGAACAAAGTGACAAATGGCCTACAGCTGTGAGAGCAAATGGACATCTCCTCCTGAACTCTGA
GAAGATGTCAAAATCCACAGGCAACTTCCTCACTTTGACCCAAGCTATTGACAAATTTTCAGCAGATGGAATGCGTTTGGCTCTGGCTGA
TGCTGGTGACACTGTAGAAGATGCCAACTTTGTGGAAGCCATGGCAGATGCAGGTATTCTCCGTCTGTACACCTGGGTAGAGTGGGTGAA
AGAAATGGTTGCCAACTGGGACAGCCTAAGAAGTGGTCCTGCCAGCACTTTCAATGATAGAGTTTTTGCCAGTGAATTGAATGCAGGAAT
TATAAAAACAGATCAAAACTATGAAAAGATGATGTTTAAAGAAGCTTTGAAAACAGGGTTTTTTGAGTTTCAGGCCGCAAAAGATAAGTA
CCGTGAATTGGCTGTGGAAGGGATGCACAGAGAACTTGTGTTCCGGTTTATTGAAGTTCAGACACTTCTCCTCGCTCCATTCTGTCCACA
TTTGTGTGAGCACATCTGGACACTCCTGGGAAAGCCTGACTCAATTATGAATGCTTCATGGCCTGTGGCAGGTCCTGTTAATGAAGTTTT
AATACACTCCTCACAGTATCTTATGGAAGTAACACATGACCTTAGACTACGACTCAAGAACTATATGATGCCAGCTAAAGGGAAGAAGAC
TGACAAACAACCCCTGCAGAAGCCCTCACATTGCACCATCTATGTGGCAAAGAACTATCCACCTTGGCAACATACCACCCTGTCTGTTCT
ACGTAAACACTTTGAGGCCAATAACGGAAAACTGCCTGACAACAAAGTCATTGCTAGTGAACTAGGCAGTATGCCAGAACTGAAGAAATA
CATGAAGAAAGTCATGCCATTTGTTGCCATGATTAAGGAAAATCTGGAGAAGATGGGGCCTCGTATTCTGGATTTGCAATTAGAATTTGA
TGAAAAGGCTGTGCTTATGGAGAATATAGTCTATCTGACTAATTCGCTTGAGCTAGAACACATAGAAGTCAAGTTTGCCTCCGAAGCAGA
AGATAAAATCAGGGAAGACTGCTGTCCTGGGAAACCACTTAATGTTTTTAGAATAGAACCTGGTGTGTCCGTTTCTCTGGTGAATCCCCA
GCCATCCAATGGCCACTTCTCAACCAAAATTGAAATCAGGCAAGGAGATAACTGTGATTCCATAATCAGGCGTTTAATGAAAATGAATCG
AGGAATTAAAGACCTTTCCAAAGTGAAACTGATGAGATTTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTA
CACCGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGT
GGATATTGGCGATACAATAATCTATCTGGTTCATTAAACTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGA
TTGTGTCTACTGATTGGCTATCAGAACCTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAA
TTCTATCAAGTCATCTTTGATTCCTGGACCTAATAAATTTTTTTTCCCTTTCTTTGGGTGTCCAAGAGAAATGGTTTTTGCCAAACTCTT
TTTAAAAAACAAATTGTTGCTATTTCCTAGAAGTTTCTGGTTTTTAAGATGAACATAAAAGTGTCAGTATGCTTCTTTTATGAGGTGTAC
TTTATACTTTGATGAAGGCTAAGGTGTACCTAACAGCTTTTTATAGTATATTCATTTATGGAGTTAGCTGTATTTTTTTTTAAAAAAGAA
AAGTAGTAAATTAGCAGCTTTTTTTTTTAAATGAAGAGAACTTCATGATGATTTAAAAGAACTAATGAGAATATTTTGACTTGACTTCAA
TTACTAAGTATTTTGTATAAAGAACAAATAGGTCCTGCATTTTATAAGACTTTTTAAAGCTTTAATTATTCAACTAAGAACCAATAATGG
CTTCTTCAAGGCTAATATCAATAGTTTATAAGCAGTATATTTCACCTACACTAAATATGGGCATTTTAAAAGAAGATTCCCCCCTTCCCC
CCCAGAAATCTGCATTTACTAAATTTGTCTTAAGTCCAATTGTGTTTAAAGGTCATGCTGGTCGGGTGTGGTGGCTCACACCTATAATCC
CAGCACTTTGGGAGGCCAAGGTGGGCAGTCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAA
AAATACAAAAATTAGCTTGGCATGGTGGCGGGTACCTGTAATCCCAGCTGCTTGGGAGTGTGAGGCAGGAGAATCGCTTGAACCTGGGAG
ACCGAGGTTGCAGTGAGCTGAAACCGTGCCATTGCACTCCAGCTTAGGCAACAAGAGTGAAACTCTGTCTCAATCAATCCATCAATCAAT

>51875_51875_2_MAT2B-LARS_MAT2B_chr5_162932755_ENST00000321757_LARS_chr5_145557228_ENST00000394434_length(amino acids)=1195AA_BP=21
MVGREKELSIHFVPGSCRLVEERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCE
FAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIM
KSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDH
DRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTK
DNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPV
IEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDE
CVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQ
GGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWP
TAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPAST
FNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIM
NASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKV
IASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVF
RIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDL

--------------------------------------------------------------
>51875_51875_3_MAT2B-LARS_MAT2B_chr5_162932755_ENST00000321757_LARS_chr5_145557228_ENST00000545646_length(transcript)=3852nt_BP=202nt
GCAGCGGAAGCCGGAAGCGGCGAGCGGGGTCGTTCTGGGCCTAGGGGAGGCGGGCCGAGGGCGTCTGAGCTGAGGCCCGCGTCGATCCTG
GGTTGGAGGAGGTGGCGGCCGCTGAGGCTGCGGCGTGAAGACGGCGGGCATGGTGGGGCGGGAGAAAGAGCTCTCTATACACTTTGTTCC
CGGGAGCTGTCGGCTGGTGGAGGAAAGAAAAGGAACAGCCAAAGTGGACTTTTTGAAGAAGATTGAGAAAGAAATCCAACAGAAATGGGA
TACTGAGAGAGTGTTTGAGGTCAATGCATCTAATTTAGAGAAACAGACCAGCAAGGGCAAGTATTTTGTAACCTTCCCATATCCATATAT
GAATGGACGCCTTCATTTGGGACACACGTTTTCTTTATCCAAATGTGAGTTTGCTGTAGGGTACCAGCGATTGAAAGGAAAATGTTGTCT
GTTTCCCTTTGGCCTGCACTGTACTGGAATGCCTATTAAGAGTAAAGCTGCTGCTAAAGCTGGATCTTCTAAATACCAGTGGGGCATTAT
GAAATCCCTTGGCCTGTCTGATGAAGAGATAGTAAAATTTTCTGAAGCAGAACATTGGCTTGATTATTTCCCGCCACTGGCTATTCAGGA
TTTAAAAAGAATGGGTTTGAAGGTAGACTGGCGTCGTTCCTTCATCACCACTGATGTTAATCCTTACTATGATTCATTTGTCAGATGGCA
ATTTTTAACATTAAGAGAAAGAAACAAAATTAAATTTGGGAAGCGGTATACAATTTACTCTCCGAAAGATGGACAGCCTTGCATGGATCA
TGATAGACAAACTGGAGAGGGTGTTGGACCTCAGGAATATACTTTACTCAAATTGAAGGTGCTTGAGCCATACCCATCTAAATTAAGTGG
CCTGAAAGGTAAAAATATTTTCTTGGTGGCTGCTACTCTCAGACCTGAGACCATGTTTGGGCAGACAAATTGTTGGGTTCGTCCTGATAT
GAAGTACATTGGATTTGAGACGGTGAATGGTGATATATTCATCTGTACCCAAAAAGCAGCCAGGAATATGTCATACCAGGGCTTTACCAA
AGACAATGGCGTGGTGCCTGTTGTTAAGGAATTAATGGGGGAGGAAATTCTTGGTGCATCACTTTCTGCACCTTTAACATCATACAAGGT
GATCTATGTTCTCCCAATGCTAACTATTAAGGAGGATAAAGGCACTGGTGTGGTTACAAGTGTTCCTTCCGACTCCCCTGATGATATTGC
TGCCCTCAGAGACTTGAAGAAAAAGCAAGCCTTACGAGCAAAATATGGAATTAGAGATGACATGGTCTTGCCATTTGAGCCGGTGCCAGT
CATTGAAATCCCAGGTTTTGGAAATCTTTCTGCTGTAACCATTTGTGATGAGTTGAAAATTCAGAGCCAGAATGACCGGGAAAAACTTGC
AGAAGCAAAGGAGAAGATATATCTAAAAGGATTTTATGAGGGTATCATGTTGGTGGATGGATTTAAAGGACAGAAGGTTCAAGATGTAAA
GAAGACTATTCAGAAAAAGATGATTGACGCTGGAGATGCACTTATTTACATGGAACCAGAGAAACAAGTGATGTCCAGGTCGTCAGATGA
ATGTGTTGTGGCTCTGTGTGACCAGTGGTACTTGGATTATGGAGAAGAGAATTGGAAGAAACAGACATCTCAGTGCTTGAAGAACCTGGA
AACATTCTGTGAGGAGACCAGGAGGAATTTTGAAGCCACCTTAGGTTGGCTACAAGAACATGCTTGCTCAAGAACTTATGGTCTAGGCAC
TCACCTGCCTTGGGATGAGCAGTGGCTGATTGAATCACTTTCTGACTCCACTATTTACATGGCATTTTACACAGTTGCACACCTATTGCA
GGGGGGTAACTTGCATGGACAGGCAGAGTCTCCGCTGGGCATTAGACCGCAACAGATGACCAAGGAAGTTTGGGATTATGTTTTCTTCAA
GGAGGCTCCATTTCCTAAGACTCAGATTGCAAAGGAAAAATTAGATCAGTTAAAGCAGGAGTTTGAATTCTGGTATCCTGTTGATCTTCG
CGTCTCTGGCAAGGATCTTGTTCCAAATCATCTTTCATATTACCTTTATAATCATGTGGCTATGTGGCCGGAACAAAGTGACAAATGGCC
TACAGCTGTGAGAGCAAATGGACATCTCCTCCTGAACTCTGAGAAGATGTCAAAATCCACAGGCAACTTCCTCACTTTGACCCAAGCTAT
TGACAAATTTTCAGCAGATGGAATGCGTTTGGCTCTGGCTGATGCTGGTGACACTGTAGAAGATGCCAACTTTGTGGAAGCCATGGCAGA
TGCAGGTATTCTCCGTCTGTACACCTGGGTAGAGTGGGTGAAAGAAATGGTTGCCAACTGGGACAGCCTAAGAAGTGGTCCTGCCAGCAC
TTTCAATGATAGAGTTTTTGCCAGTGAATTGAATGCAGGAATTATAAAAACAGATCAAAACTATGAAAAGATGATGTTTAAAGAAGCTTT
GAAAACAGGGTTTTTTGAGTTTCAGGCCGCAAAAGATAAGTACCGTGAATTGGCTGTGGAAGGGATGCACAGAGAACTTGTGTTCCGGTT
TATTGAAGTTCAGACACTTCTCCTCGCTCCATTCTGTCCACATTTGTGTGAGCACATCTGGACACTCCTGGGAAAGCCTGACTCAATTAT
GAATGCTTCATGGCCTGTGGCAGGTCCTGTTAATGAAGTTTTAATACACTCCTCACAGTATCTTATGGAAGTAACACATGACCTTAGACT
ACGACTCAAGAACTATATGATGCCAGCTAAAGGGAAGAAGACTGACAAACAACCCCTGCAGAAGCCCTCACATTGCACCATCTATGTGGC
AAAGAACTATCCACCTTGGCAACATACCACCCTGTCTGTTCTACGTAAACACTTTGAGGCCAATAACGGAAAACTGCCTGACAACAAAGT
CATTGCTAGTGAACTAGGCAGTATGCCAGAACTGAAGAAATACATGAAGAAAGTCATGCCATTTGTTGCCATGATTAAGGAAAATCTGGA
GAAGATGGGGCCTCGTATTCTGGATTTGCAATTAGAATTTGATGAAAAGGCTGTGCTTATGGAGAATATAGTCTATCTGACTAATTCGCT
TGAGCTAGAACACATAGAAGTCAAGTTTGCCTCCGAAGCAGAAGATAAAATCAGGGAAGACTGCTGTCCTGGGAAACCACTTAATGTTTT
TAGAATAGAACCTGGTGTGTCCGTTTCTCTGGTGAATCCCCAGCCATCCAATGGCCACTTCTCAACCAAAATTGAAATCAGGCAAGGAGA
TAACTGTGATTCCATAATCAGGCGTTTAATGAAAATGAATCGAGGAATTAAAGACCTTTCCAAAGTGAAACTGATGAGATTTGATGATCC
ACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCAATGTGGACCT
CATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGTGGATATTGGCGATACAATAATCTATCTGGTTCATTAAACTCATGCACA
TTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGGCTATCAGAACCTTAGGCTGGACCTAAATAGA
TTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTCTATCAAGTCATCTTTGATTCCTGGACCTAATAAATTTTTTTTCCC

>51875_51875_3_MAT2B-LARS_MAT2B_chr5_162932755_ENST00000321757_LARS_chr5_145557228_ENST00000545646_length(amino acids)=1149AA_BP=21
MVGREKELSIHFVPGSCRLVEERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCE
FAVGYQRLKGKCCLFPFGLHCTGMPIKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFIT
TDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPE
TMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTG
VVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIM
LVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGW
LQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQ
LKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAG
DTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRE
LAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDK
QPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEK
AVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGI

--------------------------------------------------------------
>51875_51875_4_MAT2B-LARS_MAT2B_chr5_162932755_ENST00000518095_LARS_chr5_145557228_ENST00000274562_length(transcript)=3775nt_BP=136nt
GAGCTGAGGCCCGCGTCGATCCTGGGTTGGAGGAGGTGGCGGCCGCTGAGGCTGCGGCGTGAAGACGGCGGGCATGGTGGGGCGGGAGAA
AGAGCTCTCTATACACTTTGTTCCCGGGAGCTGTCGGCTGGTGGAGGAAAGAAAAGGAACAGCCAAAGTGGACTTTTTGAAGAAGATTGA
GAAAGAAATCCAACAGAAATGGGATACTGAGAGAGTGTTTGAGGTCAATGCATCTAATTTAGAGAAACAGACCAGCAAGGGCAAGTATTT
TGTAACCTTCCCATATCCATATATGAATGGACGCCTTCATTTGGGACACACGTTTTCTTTATCCAAATGTGAGGCATGTGCTGATAAGTT
GAAAAGAGAAATAGAGCTGTATGGTTGCCCCCCTGATTTTCCAGATGAAGAAGAGGAAGAGGAAGAAACCAGTGTTAAAACAGAAGATAT
AATAATTAAGGATAAAGCTAAAGGAAAAAAGAGTAAAGCTGCTGCTAAAGCTGGATCTTCTAAATACCAGTGGGGCATTATGAAATCCCT
TGGCCTGTCTGATGAAGAGATAGTAAAATTTTCTGAAGCAGAACATTGGCTTGATTATTTCCCGCCACTGGCTATTCAGGATTTAAAAAG
AATGGGTTTGAAGGTAGACTGGCGTCGTTCCTTCATCACCACTGATGTTAATCCTTACTATGATTCATTTGTCAGATGGCAATTTTTAAC
ATTAAGAGAAAGAAACAAAATTAAATTTGGGAAGCGGTATACAATTTACTCTCCGAAAGATGGACAGCCTTGCATGGATCATGATAGACA
AACTGGAGAGGGTGTTGGACCTCAGGAATATACTTTACTCAAATTGAAGGTGCTTGAGCCATACCCATCTAAATTAAGTGGCCTGAAAGG
TAAAAATATTTTCTTGGTGGCTGCTACTCTCAGACCTGAGACCATGTTTGGGCAGACAAATTGTTGGGTTCGTCCTGATATGAAGTACAT
TGGATTTGAGACGGTGAATGGTGATATATTCATCTGTACCCAAAAAGCAGCCAGGAATATGTCATACCAGGGCTTTACCAAAGACAATGG
CGTGGTGCCTGTTGTTAAGGAATTAATGGGGGAGGAAATTCTTGGTGCATCACTTTCTGCACCTTTAACATCATACAAGGTGATCTATGT
TCTCCCAATGCTAACTATTAAGGAGGATAAAGGCACTGGTGTGGTTACAAGTGTTCCTTCCGACTCCCCTGATGATATTGCTGCCCTCAG
AGACTTGAAGAAAAAGCAAGCCTTACGAGCAAAATATGGAATTAGAGATGACATGGTCTTGCCATTTGAGCCGGTGCCAGTCATTGAAAT
CCCAGGTTTTGGAAATCTTTCTGCTGTAACCATTTGTGATGAGTTGAAAATTCAGAGCCAGAATGACCGGGAAAAACTTGCAGAAGCAAA
GGAGAAGATATATCTAAAAGGATTTTATGAGGGTATCATGTTGGTGGATGGATTTAAAGGACAGAAGGTTCAAGATGTAAAGAAGACTAT
TCAGAAAAAGATGATTGACGCTGGAGATGCACTTATTTACATGGAACCAGAGAAACAAGTGATGTCCAGGTCGTCAGATGAATGTGTTGT
GGCTCTGTGTGACCAGTGGTACTTGGATTATGGAGAAGAGAATTGGAAGAAACAGACATCTCAGTGCTTGAAGAACCTGGAAACATTCTG
TGAGGAGACCAGGAGGAATTTTGAAGCCACCTTAGGTTGGCTACAAGAACATGCTTGCTCAAGAACTTATGGTCTAGGCACTCACCTGCC
TTGGGATGAGCAGTGGCTGATTGAATCACTTTCTGACTCCACTATTTACATGGCATTTTACACAGTTGCACACCTATTGCAGGGGGGTAA
CTTGCATGGACAGGCAGAGTCTCCGCTGGGCATTAGACCGCAACAGATGACCAAGGAAGTTTGGGATTATGTTTTCTTCAAGGAGGCTCC
ATTTCCTAAGACTCAGATTGCAAAGGAAAAATTAGATCAGTTAAAGCAGGAGTTTGAATTCTGGTATCCTGTTGATCTTCGCGTCTCTGG
CAAGGATCTTGTTCCAAATCATCTTTCATATTACCTTTATAATCATGTGGCTATGTGGCCGGAACAAAGTGACAAATGGCCTACAGCTGT
GAGAGCAAATGGACATCTCCTCCTGAACTCTGAGAAGATGTCAAAATCCACAGGCAACTTCCTCACTTTGACCCAAGCTATTGACAAATT
TTCAGCAGATGGAATGCGTTTGGCTCTGGCTGATGCTGGTGACACTGTAGAAGATGCCAACTTTGTGGAAGCCATGGCAGATGCAGGTAT
TCTCCGTCTGTACACCTGGGTAGAGTGGGTGAAAGAAATGGTTGCCAACTGGGACAGCCTAAGAAGTGGTCCTGCCAGCACTTTCAATGA
TAGAGTTTTTGCCAGTGAATTGAATGCAGGAATTATAAAAACAGATCAAAACTATGAAAAGATGATGTTTAAAGAAGCTTTGAAAACAGG
GTTTTTTGAGTTTCAGGCCGCAAAAGATAAGTACCGTGAATTGGCTGTGGAAGGGATGCACAGAGAACTTGTGTTCCGGTTTATTGAAGT
TCAGACACTTCTCCTCGCTCCATTCTGTCCACATTTGTGTGAGCACATCTGGACACTCCTGGGAAAGCCTGACTCAATTATGAATGCTTC
ATGGCCTGTGGCAGGTCCTGTTAATGAAGTTTTAATACACTCCTCACAGTATCTTATGGAAGTAACACATGACCTTAGACTACGACTCAA
GAACTATATGATGCCAGCTAAAGGGAAGAAGACTGACAAACAACCCCTGCAGAAGCCCTCACATTGCACCATCTATGTGGCAAAGAACTA
TCCACCTTGGCAACATACCACCCTGTCTGTTCTACGTAAACACTTTGAGGCCAATAACGGAAAACTGCCTGACAACAAAGTCATTGCTAG
TGAACTAGGCAGTATGCCAGAACTGAAGAAATACATGAAGAAAGTCATGCCATTTGTTGCCATGATTAAGGAAAATCTGGAGAAGATGGG
GCCTCGTATTCTGGATTTGCAATTAGAATTTGATGAAAAGGCTGTGCTTATGGAGAATATAGTCTATCTGACTAATTCGCTTGAGCTAGA
ACACATAGAAGTCAAGTTTGCCTCCGAAGCAGAAGATAAAATCAGGGAAGACTGCTGTCCTGGGAAACCACTTAATGTTTTTAGAATAGA
ACCTGGTGTGTCCGTTTCTCTGGTGAATCCCCAGCCATCCAATGGCCACTTCTCAACCAAAATTGAAATCAGGCAAGGAGATAACTGTGA
TTCCATAATCAGGCGTTTAATGAAAATGAATCGAGGAATTAAAGACCTTTCCAAAGTGAAACTGATGAGATTTGATGATCCACTGTTGGG
GCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCAATGTGGACCTCATGAGCAA
GAAAATTCATCTGACTGAGAATGGGATAAGGGTGGATATTGGCGATACAATAATCTATCTGGTTCATTAAACTCATGCACATTGGAGATT
TATCCTGGTTTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGGCTATCAGAACCTTAGGCTGGACCTAAATAGATTGATTTCA

>51875_51875_4_MAT2B-LARS_MAT2B_chr5_162932755_ENST00000518095_LARS_chr5_145557228_ENST00000274562_length(amino acids)=1168AA_BP=21
MVGREKELSIHFVPGSCRLVEERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCE
ACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLA
IQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSK
LSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTS
YKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDRE
KLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLK
NLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYV
FFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLT
QAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFK
EALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHD
LRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKE
NLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIR

--------------------------------------------------------------
>51875_51875_5_MAT2B-LARS_MAT2B_chr5_162932755_ENST00000518095_LARS_chr5_145557228_ENST00000394434_length(transcript)=4729nt_BP=136nt
GAGCTGAGGCCCGCGTCGATCCTGGGTTGGAGGAGGTGGCGGCCGCTGAGGCTGCGGCGTGAAGACGGCGGGCATGGTGGGGCGGGAGAA
AGAGCTCTCTATACACTTTGTTCCCGGGAGCTGTCGGCTGGTGGAGGAAAGAAAAGGAACAGCCAAAGTGGACTTTTTGAAGAAGATTGA
GAAAGAAATCCAACAGAAATGGGATACTGAGAGAGTGTTTGAGGTCAATGCATCTAATTTAGAGAAACAGACCAGCAAGGGCAAGTATTT
TGTAACCTTCCCATATCCATATATGAATGGACGCCTTCATTTGGGACACACGTTTTCTTTATCCAAATGTGAGTTTGCTGTAGGGTACCA
GCGATTGAAAGGAAAATGTTGTCTGTTTCCCTTTGGCCTGCACTGTACTGGAATGCCTATTAAGGCATGTGCTGATAAGTTGAAAAGAGA
AATAGAGCTGTATGGTTGCCCCCCTGATTTTCCAGATGAAGAAGAGGAAGAGGAAGAAACCAGTGTTAAAACAGAAGATATAATAATTAA
GGATAAAGCTAAAGGAAAAAAGAGTAAAGCTGCTGCTAAAGCTGGATCTTCTAAATACCAGTGGGGCATTATGAAATCCCTTGGCCTGTC
TGATGAAGAGATAGTAAAATTTTCTGAAGCAGAACATTGGCTTGATTATTTCCCGCCACTGGCTATTCAGGATTTAAAAAGAATGGGTTT
GAAGGTAGACTGGCGTCGTTCCTTCATCACCACTGATGTTAATCCTTACTATGATTCATTTGTCAGATGGCAATTTTTAACATTAAGAGA
AAGAAACAAAATTAAATTTGGGAAGCGGTATACAATTTACTCTCCGAAAGATGGACAGCCTTGCATGGATCATGATAGACAAACTGGAGA
GGGTGTTGGACCTCAGGAATATACTTTACTCAAATTGAAGGTGCTTGAGCCATACCCATCTAAATTAAGTGGCCTGAAAGGTAAAAATAT
TTTCTTGGTGGCTGCTACTCTCAGACCTGAGACCATGTTTGGGCAGACAAATTGTTGGGTTCGTCCTGATATGAAGTACATTGGATTTGA
GACGGTGAATGGTGATATATTCATCTGTACCCAAAAAGCAGCCAGGAATATGTCATACCAGGGCTTTACCAAAGACAATGGCGTGGTGCC
TGTTGTTAAGGAATTAATGGGGGAGGAAATTCTTGGTGCATCACTTTCTGCACCTTTAACATCATACAAGGTGATCTATGTTCTCCCAAT
GCTAACTATTAAGGAGGATAAAGGCACTGGTGTGGTTACAAGTGTTCCTTCCGACTCCCCTGATGATATTGCTGCCCTCAGAGACTTGAA
GAAAAAGCAAGCCTTACGAGCAAAATATGGAATTAGAGATGACATGGTCTTGCCATTTGAGCCGGTGCCAGTCATTGAAATCCCAGGTTT
TGGAAATCTTTCTGCTGTAACCATTTGTGATGAGTTGAAAATTCAGAGCCAGAATGACCGGGAAAAACTTGCAGAAGCAAAGGAGAAGAT
ATATCTAAAAGGATTTTATGAGGGTATCATGTTGGTGGATGGATTTAAAGGACAGAAGGTTCAAGATGTAAAGAAGACTATTCAGAAAAA
GATGATTGACGCTGGAGATGCACTTATTTACATGGAACCAGAGAAACAAGTGATGTCCAGGTCGTCAGATGAATGTGTTGTGGCTCTGTG
TGACCAGTGGTACTTGGATTATGGAGAAGAGAATTGGAAGAAACAGACATCTCAGTGCTTGAAGAACCTGGAAACATTCTGTGAGGAGAC
CAGGAGGAATTTTGAAGCCACCTTAGGTTGGCTACAAGAACATGCTTGCTCAAGAACTTATGGTCTAGGCACTCACCTGCCTTGGGATGA
GCAGTGGCTGATTGAATCACTTTCTGACTCCACTATTTACATGGCATTTTACACAGTTGCACACCTATTGCAGGGGGGTAACTTGCATGG
ACAGGCAGAGTCTCCGCTGGGCATTAGACCGCAACAGATGACCAAGGAAGTTTGGGATTATGTTTTCTTCAAGGAGGCTCCATTTCCTAA
GACTCAGATTGCAAAGGAAAAATTAGATCAGTTAAAGCAGGAGTTTGAATTCTGGTATCCTGTTGATCTTCGCGTCTCTGGCAAGGATCT
TGTTCCAAATCATCTTTCATATTACCTTTATAATCATGTGGCTATGTGGCCGGAACAAAGTGACAAATGGCCTACAGCTGTGAGAGCAAA
TGGACATCTCCTCCTGAACTCTGAGAAGATGTCAAAATCCACAGGCAACTTCCTCACTTTGACCCAAGCTATTGACAAATTTTCAGCAGA
TGGAATGCGTTTGGCTCTGGCTGATGCTGGTGACACTGTAGAAGATGCCAACTTTGTGGAAGCCATGGCAGATGCAGGTATTCTCCGTCT
GTACACCTGGGTAGAGTGGGTGAAAGAAATGGTTGCCAACTGGGACAGCCTAAGAAGTGGTCCTGCCAGCACTTTCAATGATAGAGTTTT
TGCCAGTGAATTGAATGCAGGAATTATAAAAACAGATCAAAACTATGAAAAGATGATGTTTAAAGAAGCTTTGAAAACAGGGTTTTTTGA
GTTTCAGGCCGCAAAAGATAAGTACCGTGAATTGGCTGTGGAAGGGATGCACAGAGAACTTGTGTTCCGGTTTATTGAAGTTCAGACACT
TCTCCTCGCTCCATTCTGTCCACATTTGTGTGAGCACATCTGGACACTCCTGGGAAAGCCTGACTCAATTATGAATGCTTCATGGCCTGT
GGCAGGTCCTGTTAATGAAGTTTTAATACACTCCTCACAGTATCTTATGGAAGTAACACATGACCTTAGACTACGACTCAAGAACTATAT
GATGCCAGCTAAAGGGAAGAAGACTGACAAACAACCCCTGCAGAAGCCCTCACATTGCACCATCTATGTGGCAAAGAACTATCCACCTTG
GCAACATACCACCCTGTCTGTTCTACGTAAACACTTTGAGGCCAATAACGGAAAACTGCCTGACAACAAAGTCATTGCTAGTGAACTAGG
CAGTATGCCAGAACTGAAGAAATACATGAAGAAAGTCATGCCATTTGTTGCCATGATTAAGGAAAATCTGGAGAAGATGGGGCCTCGTAT
TCTGGATTTGCAATTAGAATTTGATGAAAAGGCTGTGCTTATGGAGAATATAGTCTATCTGACTAATTCGCTTGAGCTAGAACACATAGA
AGTCAAGTTTGCCTCCGAAGCAGAAGATAAAATCAGGGAAGACTGCTGTCCTGGGAAACCACTTAATGTTTTTAGAATAGAACCTGGTGT
GTCCGTTTCTCTGGTGAATCCCCAGCCATCCAATGGCCACTTCTCAACCAAAATTGAAATCAGGCAAGGAGATAACTGTGATTCCATAAT
CAGGCGTTTAATGAAAATGAATCGAGGAATTAAAGACCTTTCCAAAGTGAAACTGATGAGATTTGATGATCCACTGTTGGGGCCTCGACG
AGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCA
TCTGACTGAGAATGGGATAAGGGTGGATATTGGCGATACAATAATCTATCTGGTTCATTAAACTCATGCACATTGGAGATTTATCCTGGT
TTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGGCTATCAGAACCTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACC
ATCCAATTCTGCATGTATTCATAATTCTATCAAGTCATCTTTGATTCCTGGACCTAATAAATTTTTTTTCCCTTTCTTTGGGTGTCCAAG
AGAAATGGTTTTTGCCAAACTCTTTTTAAAAAACAAATTGTTGCTATTTCCTAGAAGTTTCTGGTTTTTAAGATGAACATAAAAGTGTCA
GTATGCTTCTTTTATGAGGTGTACTTTATACTTTGATGAAGGCTAAGGTGTACCTAACAGCTTTTTATAGTATATTCATTTATGGAGTTA
GCTGTATTTTTTTTTAAAAAAGAAAAGTAGTAAATTAGCAGCTTTTTTTTTTAAATGAAGAGAACTTCATGATGATTTAAAAGAACTAAT
GAGAATATTTTGACTTGACTTCAATTACTAAGTATTTTGTATAAAGAACAAATAGGTCCTGCATTTTATAAGACTTTTTAAAGCTTTAAT
TATTCAACTAAGAACCAATAATGGCTTCTTCAAGGCTAATATCAATAGTTTATAAGCAGTATATTTCACCTACACTAAATATGGGCATTT
TAAAAGAAGATTCCCCCCTTCCCCCCCAGAAATCTGCATTTACTAAATTTGTCTTAAGTCCAATTGTGTTTAAAGGTCATGCTGGTCGGG
TGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGTCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAAC
ATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTTGGCATGGTGGCGGGTACCTGTAATCCCAGCTGCTTGGGAGTGTGAGGC
AGGAGAATCGCTTGAACCTGGGAGACCGAGGTTGCAGTGAGCTGAAACCGTGCCATTGCACTCCAGCTTAGGCAACAAGAGTGAAACTCT

>51875_51875_5_MAT2B-LARS_MAT2B_chr5_162932755_ENST00000518095_LARS_chr5_145557228_ENST00000394434_length(amino acids)=1195AA_BP=21
MVGREKELSIHFVPGSCRLVEERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCE
FAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIM
KSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDH
DRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTK
DNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPV
IEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDE
CVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQ
GGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWP
TAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPAST
FNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIM
NASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKV
IASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVF
RIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDL

--------------------------------------------------------------
>51875_51875_6_MAT2B-LARS_MAT2B_chr5_162932755_ENST00000518095_LARS_chr5_145557228_ENST00000545646_length(transcript)=3786nt_BP=136nt
GAGCTGAGGCCCGCGTCGATCCTGGGTTGGAGGAGGTGGCGGCCGCTGAGGCTGCGGCGTGAAGACGGCGGGCATGGTGGGGCGGGAGAA
AGAGCTCTCTATACACTTTGTTCCCGGGAGCTGTCGGCTGGTGGAGGAAAGAAAAGGAACAGCCAAAGTGGACTTTTTGAAGAAGATTGA
GAAAGAAATCCAACAGAAATGGGATACTGAGAGAGTGTTTGAGGTCAATGCATCTAATTTAGAGAAACAGACCAGCAAGGGCAAGTATTT
TGTAACCTTCCCATATCCATATATGAATGGACGCCTTCATTTGGGACACACGTTTTCTTTATCCAAATGTGAGTTTGCTGTAGGGTACCA
GCGATTGAAAGGAAAATGTTGTCTGTTTCCCTTTGGCCTGCACTGTACTGGAATGCCTATTAAGAGTAAAGCTGCTGCTAAAGCTGGATC
TTCTAAATACCAGTGGGGCATTATGAAATCCCTTGGCCTGTCTGATGAAGAGATAGTAAAATTTTCTGAAGCAGAACATTGGCTTGATTA
TTTCCCGCCACTGGCTATTCAGGATTTAAAAAGAATGGGTTTGAAGGTAGACTGGCGTCGTTCCTTCATCACCACTGATGTTAATCCTTA
CTATGATTCATTTGTCAGATGGCAATTTTTAACATTAAGAGAAAGAAACAAAATTAAATTTGGGAAGCGGTATACAATTTACTCTCCGAA
AGATGGACAGCCTTGCATGGATCATGATAGACAAACTGGAGAGGGTGTTGGACCTCAGGAATATACTTTACTCAAATTGAAGGTGCTTGA
GCCATACCCATCTAAATTAAGTGGCCTGAAAGGTAAAAATATTTTCTTGGTGGCTGCTACTCTCAGACCTGAGACCATGTTTGGGCAGAC
AAATTGTTGGGTTCGTCCTGATATGAAGTACATTGGATTTGAGACGGTGAATGGTGATATATTCATCTGTACCCAAAAAGCAGCCAGGAA
TATGTCATACCAGGGCTTTACCAAAGACAATGGCGTGGTGCCTGTTGTTAAGGAATTAATGGGGGAGGAAATTCTTGGTGCATCACTTTC
TGCACCTTTAACATCATACAAGGTGATCTATGTTCTCCCAATGCTAACTATTAAGGAGGATAAAGGCACTGGTGTGGTTACAAGTGTTCC
TTCCGACTCCCCTGATGATATTGCTGCCCTCAGAGACTTGAAGAAAAAGCAAGCCTTACGAGCAAAATATGGAATTAGAGATGACATGGT
CTTGCCATTTGAGCCGGTGCCAGTCATTGAAATCCCAGGTTTTGGAAATCTTTCTGCTGTAACCATTTGTGATGAGTTGAAAATTCAGAG
CCAGAATGACCGGGAAAAACTTGCAGAAGCAAAGGAGAAGATATATCTAAAAGGATTTTATGAGGGTATCATGTTGGTGGATGGATTTAA
AGGACAGAAGGTTCAAGATGTAAAGAAGACTATTCAGAAAAAGATGATTGACGCTGGAGATGCACTTATTTACATGGAACCAGAGAAACA
AGTGATGTCCAGGTCGTCAGATGAATGTGTTGTGGCTCTGTGTGACCAGTGGTACTTGGATTATGGAGAAGAGAATTGGAAGAAACAGAC
ATCTCAGTGCTTGAAGAACCTGGAAACATTCTGTGAGGAGACCAGGAGGAATTTTGAAGCCACCTTAGGTTGGCTACAAGAACATGCTTG
CTCAAGAACTTATGGTCTAGGCACTCACCTGCCTTGGGATGAGCAGTGGCTGATTGAATCACTTTCTGACTCCACTATTTACATGGCATT
TTACACAGTTGCACACCTATTGCAGGGGGGTAACTTGCATGGACAGGCAGAGTCTCCGCTGGGCATTAGACCGCAACAGATGACCAAGGA
AGTTTGGGATTATGTTTTCTTCAAGGAGGCTCCATTTCCTAAGACTCAGATTGCAAAGGAAAAATTAGATCAGTTAAAGCAGGAGTTTGA
ATTCTGGTATCCTGTTGATCTTCGCGTCTCTGGCAAGGATCTTGTTCCAAATCATCTTTCATATTACCTTTATAATCATGTGGCTATGTG
GCCGGAACAAAGTGACAAATGGCCTACAGCTGTGAGAGCAAATGGACATCTCCTCCTGAACTCTGAGAAGATGTCAAAATCCACAGGCAA
CTTCCTCACTTTGACCCAAGCTATTGACAAATTTTCAGCAGATGGAATGCGTTTGGCTCTGGCTGATGCTGGTGACACTGTAGAAGATGC
CAACTTTGTGGAAGCCATGGCAGATGCAGGTATTCTCCGTCTGTACACCTGGGTAGAGTGGGTGAAAGAAATGGTTGCCAACTGGGACAG
CCTAAGAAGTGGTCCTGCCAGCACTTTCAATGATAGAGTTTTTGCCAGTGAATTGAATGCAGGAATTATAAAAACAGATCAAAACTATGA
AAAGATGATGTTTAAAGAAGCTTTGAAAACAGGGTTTTTTGAGTTTCAGGCCGCAAAAGATAAGTACCGTGAATTGGCTGTGGAAGGGAT
GCACAGAGAACTTGTGTTCCGGTTTATTGAAGTTCAGACACTTCTCCTCGCTCCATTCTGTCCACATTTGTGTGAGCACATCTGGACACT
CCTGGGAAAGCCTGACTCAATTATGAATGCTTCATGGCCTGTGGCAGGTCCTGTTAATGAAGTTTTAATACACTCCTCACAGTATCTTAT
GGAAGTAACACATGACCTTAGACTACGACTCAAGAACTATATGATGCCAGCTAAAGGGAAGAAGACTGACAAACAACCCCTGCAGAAGCC
CTCACATTGCACCATCTATGTGGCAAAGAACTATCCACCTTGGCAACATACCACCCTGTCTGTTCTACGTAAACACTTTGAGGCCAATAA
CGGAAAACTGCCTGACAACAAAGTCATTGCTAGTGAACTAGGCAGTATGCCAGAACTGAAGAAATACATGAAGAAAGTCATGCCATTTGT
TGCCATGATTAAGGAAAATCTGGAGAAGATGGGGCCTCGTATTCTGGATTTGCAATTAGAATTTGATGAAAAGGCTGTGCTTATGGAGAA
TATAGTCTATCTGACTAATTCGCTTGAGCTAGAACACATAGAAGTCAAGTTTGCCTCCGAAGCAGAAGATAAAATCAGGGAAGACTGCTG
TCCTGGGAAACCACTTAATGTTTTTAGAATAGAACCTGGTGTGTCCGTTTCTCTGGTGAATCCCCAGCCATCCAATGGCCACTTCTCAAC
CAAAATTGAAATCAGGCAAGGAGATAACTGTGATTCCATAATCAGGCGTTTAATGAAAATGAATCGAGGAATTAAAGACCTTTCCAAAGT
GAAACTGATGAGATTTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCCATTTCTGA
GCATGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGTGGATATTGGCGATACAATAATCTA
TCTGGTTCATTAAACTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGGCTATCAG
AACCTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTCTATCAAGTCATCTTTGATTCC
TGGACCTAATAAATTTTTTTTCCCTTTCTTTGGGTGTCCAAGAGAAATGGTTTTTGCCAAACTCTTTTTAAAAAACAAATTGTTGCTATT

>51875_51875_6_MAT2B-LARS_MAT2B_chr5_162932755_ENST00000518095_LARS_chr5_145557228_ENST00000545646_length(amino acids)=1149AA_BP=21
MVGREKELSIHFVPGSCRLVEERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCE
FAVGYQRLKGKCCLFPFGLHCTGMPIKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFIT
TDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPE
TMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTG
VVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIM
LVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGW
LQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQ
LKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAG
DTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRE
LAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDK
QPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEK
AVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MAT2B-LARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAT2B-LARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAT2B-LARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource