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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAT2B-RARS (FusionGDB2 ID:51876)

Fusion Gene Summary for MAT2B-RARS

check button Fusion gene summary
Fusion gene informationFusion gene name: MAT2B-RARS
Fusion gene ID: 51876
HgeneTgene
Gene symbol

MAT2B

RARS

Gene ID

27430

5917

Gene namemethionine adenosyltransferase 2Barginyl-tRNA synthetase 1
SynonymsMAT-II|MATIIbeta|Nbla02999|SDR23E1|TGRArgRS|DALRD1|HLD9|RARS
Cytomap

5q34

5q34

Type of geneprotein-codingprotein-coding
Descriptionmethionine adenosyltransferase 2 subunit betaMAT II betabeta regulatory subunit of methionine adenosyltransferasedTDP-4-keto-6-deoxy-D-glucose 4-reductasemethionine adenosyltransferase II, betaputative dTDP-4-keto-6-deoxy-D-glucose 4-reductaseputatiarginine--tRNA ligase, cytoplasmicarginine tRNA ligase 1, cytoplasmicarginyl-tRNA synthetase, cytoplasmic
Modification date2020031520200313
UniProtAcc

Q9NZL9

.
Ensembl transtripts involved in fusion geneENST00000280969, ENST00000321757, 
ENST00000518095, ENST00000521838, 
ENST00000520421, ENST00000231572, 
ENST00000538719, 
Fusion gene scores* DoF score5 X 3 X 5=756 X 6 X 4=144
# samples 66
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAT2B [Title/Abstract] AND RARS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAT2B(162939202)-RARS(167927595), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAT2B

GO:0006556

S-adenosylmethionine biosynthetic process

10644686|25075345

TgeneRARS

GO:0006420

arginyl-tRNA aminoacylation

25288775


check buttonFusion gene breakpoints across MAT2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RARS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-6546MAT2Bchr5

162939202

+RARSchr5

167927595

+


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Fusion Gene ORF analysis for MAT2B-RARS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000280969ENST00000520421MAT2Bchr5

162939202

+RARSchr5

167927595

+
5CDS-3UTRENST00000321757ENST00000520421MAT2Bchr5

162939202

+RARSchr5

167927595

+
5CDS-3UTRENST00000518095ENST00000520421MAT2Bchr5

162939202

+RARSchr5

167927595

+
In-frameENST00000280969ENST00000231572MAT2Bchr5

162939202

+RARSchr5

167927595

+
In-frameENST00000280969ENST00000538719MAT2Bchr5

162939202

+RARSchr5

167927595

+
In-frameENST00000321757ENST00000231572MAT2Bchr5

162939202

+RARSchr5

167927595

+
In-frameENST00000321757ENST00000538719MAT2Bchr5

162939202

+RARSchr5

167927595

+
In-frameENST00000518095ENST00000231572MAT2Bchr5

162939202

+RARSchr5

167927595

+
In-frameENST00000518095ENST00000538719MAT2Bchr5

162939202

+RARSchr5

167927595

+
intron-3CDSENST00000521838ENST00000231572MAT2Bchr5

162939202

+RARSchr5

167927595

+
intron-3CDSENST00000521838ENST00000538719MAT2Bchr5

162939202

+RARSchr5

167927595

+
intron-3UTRENST00000521838ENST00000520421MAT2Bchr5

162939202

+RARSchr5

167927595

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000280969MAT2Bchr5162939202+ENST00000231572RARSchr5167927595+17765062811666461
ENST00000280969MAT2Bchr5162939202+ENST00000538719RARSchr5167927595+17755062811666461
ENST00000321757MAT2Bchr5162939202+ENST00000231572RARSchr5167927595+16673971391557472
ENST00000321757MAT2Bchr5162939202+ENST00000538719RARSchr5167927595+16663971391557472
ENST00000518095MAT2Bchr5162939202+ENST00000231572RARSchr5167927595+1601331731491472
ENST00000518095MAT2Bchr5162939202+ENST00000538719RARSchr5167927595+1600331731491472

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000280969ENST00000231572MAT2Bchr5162939202+RARSchr5167927595+0.0006842230.99931574
ENST00000280969ENST00000538719MAT2Bchr5162939202+RARSchr5167927595+0.0006825150.9993175
ENST00000321757ENST00000231572MAT2Bchr5162939202+RARSchr5167927595+0.0004278860.9995721
ENST00000321757ENST00000538719MAT2Bchr5162939202+RARSchr5167927595+0.0004251050.99957484
ENST00000518095ENST00000231572MAT2Bchr5162939202+RARSchr5167927595+0.0004240170.99957603
ENST00000518095ENST00000538719MAT2Bchr5162939202+RARSchr5167927595+0.0004210970.9995789

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Fusion Genomic Features for MAT2B-RARS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MAT2B-RARS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:162939202/chr5:167927595)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAT2B

Q9NZL9

.
FUNCTION: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAT2Bchr5:162939202chr5:167927595ENST00000280969+2737_4075324.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162939202chr5:167927595ENST00000280969+2771_7275324.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162939202chr5:167927595ENST00000321757+2737_4086335.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162939202chr5:167927595ENST00000321757+2771_7286335.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162939202chr5:167927595ENST00000518095+2537_4086260.0Nucleotide bindingNADP
HgeneMAT2Bchr5:162939202chr5:167927595ENST00000518095+2571_7286260.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRARSchr5:162939202chr5:167927595ENST00000231572615201_212274661.0MotifNote='HIGH' region
TgeneRARSchr5:162939202chr5:167927595ENST00000231572615200_202274661.0RegionL-arginine binding


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Fusion Gene Sequence for MAT2B-RARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51876_51876_1_MAT2B-RARS_MAT2B_chr5_162939202_ENST00000280969_RARS_chr5_167927595_ENST00000231572_length(transcript)=1776nt_BP=506nt
GCAAATAGACCCAGGCTTGACTGGCAATTAAACATGAAACTTCTCATTGGGTATTTTCGAGACTACTACGGGGAATCAGCTACCAGCTTA
CTGCCATGTGGAGAACTGCACGAGATTCCGGGATTGGAATCAAAATGCTAATTTAAAAGGTCAAGTGAAGCTGCTCCTCACGTTTTGGCG
TGCCTGCGCTCTCTGCAGGCAGAAGCGAACAAAGACCCAGCAAGAGAAGGCAGAGGCTAAGACCCATCCCGTATCTGCTCTCCTGAAATA
ATTCTGGAGTCATGCCTGAAATGCCAGAGGACATGGAGCAGGAGGAAGTTAACATCCCTAATAGGAGGGTTCTGGTTACTGGTGCCACTG
GGCTTCTTGGCAGAGCTGTACACAAAGAATTTCAGCAGAATAATTGGCATGCAGTTGGCTGTGGTTTCAGAAGAGCAAGACCAAAATTTG
AACAGGTTAATCTGTTGGATTCTAATGCAGTTCATCACATCATTCATGATTTTCAGGAATCTAAGAAGAGGTTTGATACTGAGGAGGAAT
TTAAGAAGCGAGCATATCAGTGTGTAGTTCTGCTCCAGGGTAAAAACCCAGATATTACAAAAGCTTGGAAGCTTATCTGTGATGTCTCCC
GCCAAGAGTTAAATAAAATCTATGATGCATTGGACGTCTCTTTAATAGAGAGAGGGGAATCCTTCTATCAAGATAGGATGAATGATATTG
TAAAGGAATTTGAAGATAGAGGATTTGTGCAGGTGGATGATGGCAGAAAGATTGTATTTGTCCCAGGGTGTTCCATACCATTAACCATAG
TAAAATCAGATGGAGGTTATACCTATGATACATCTGACCTGGCTGCTATTAAACAAAGACTATTTGAGGAAAAAGCAGATATGATTATCT
ATGTTGTGGACAATGGACAATCTGTGCACTTCCAGACAATATTTGCTGCTGCTCAAATGATTGGTTGGTATGACCCTAAAGTAACTCGAG
TCTTCCATGCTGGATTTGGTGTGGTGCTAGGGGAAGACAAGAAAAAGTTTAAAACACGTTCGGGTGAAACAGTGCGCCTCATGGATCTTC
TGGGAGAAGGACTAAAACGATCCATGGACAAGTTGAAGGAAAAAGAAAGAGACAAGGTCTTAACTGCAGAGGAATTGAATGCTGCTCAGA
CATCCGTTGCGTATGGCTGCATCAAATATGCTGACCTTTCCCATAACCGGTTGAATGACTACATCTTCTCCTTTGACAAAATGCTAGATG
ACAGAGGAAATACAGCTGCTTACTTGTTGTATGCCTTCACTAGAATCAGGTCTATTGCACGTCTGGCCAATATTGATGAAGAAATGCTCC
AAAAAGCTGCTCGAGAAACCAAGATTCTTTTGGATCATGAGAAGGAATGGAAACTAGGCCGGTGCATTTTACGGTTCCCTGAGATTCTGC
AAAAGATTTTAGATGACTTATTTCTCCACACTCTCTGTGATTATATATATGAGCTGGCAACTGCTTTCACAGAGTTCTATGATAGCTGCT
ACTGTGTGGAGAAAGATAGACAGACTGGAAAAATATTGAAGGTGAACATGTGGCGTATGCTGCTATGTGAAGCAGTAGCTGCTGTCATGG
CCAAGGGGTTTGATATCCTGGGAATAAAACCTGTCCAAAGGATGTAATCCTTCATAGGTTTGAACACTGTGTGTTTTTACCAAAGTGGCC

>51876_51876_1_MAT2B-RARS_MAT2B_chr5_162939202_ENST00000280969_RARS_chr5_167927595_ENST00000231572_length(amino acids)=461AA_BP=74
MPEMPEDMEQEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQESKKRFDTEEEFKKR
AYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPGCSIPLTIVKSD
GGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEG
LKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQKAA
RETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGF

--------------------------------------------------------------
>51876_51876_2_MAT2B-RARS_MAT2B_chr5_162939202_ENST00000280969_RARS_chr5_167927595_ENST00000538719_length(transcript)=1775nt_BP=506nt
GCAAATAGACCCAGGCTTGACTGGCAATTAAACATGAAACTTCTCATTGGGTATTTTCGAGACTACTACGGGGAATCAGCTACCAGCTTA
CTGCCATGTGGAGAACTGCACGAGATTCCGGGATTGGAATCAAAATGCTAATTTAAAAGGTCAAGTGAAGCTGCTCCTCACGTTTTGGCG
TGCCTGCGCTCTCTGCAGGCAGAAGCGAACAAAGACCCAGCAAGAGAAGGCAGAGGCTAAGACCCATCCCGTATCTGCTCTCCTGAAATA
ATTCTGGAGTCATGCCTGAAATGCCAGAGGACATGGAGCAGGAGGAAGTTAACATCCCTAATAGGAGGGTTCTGGTTACTGGTGCCACTG
GGCTTCTTGGCAGAGCTGTACACAAAGAATTTCAGCAGAATAATTGGCATGCAGTTGGCTGTGGTTTCAGAAGAGCAAGACCAAAATTTG
AACAGGTTAATCTGTTGGATTCTAATGCAGTTCATCACATCATTCATGATTTTCAGGAATCTAAGAAGAGGTTTGATACTGAGGAGGAAT
TTAAGAAGCGAGCATATCAGTGTGTAGTTCTGCTCCAGGGTAAAAACCCAGATATTACAAAAGCTTGGAAGCTTATCTGTGATGTCTCCC
GCCAAGAGTTAAATAAAATCTATGATGCATTGGACGTCTCTTTAATAGAGAGAGGGGAATCCTTCTATCAAGATAGGATGAATGATATTG
TAAAGGAATTTGAAGATAGAGGATTTGTGCAGGTGGATGATGGCAGAAAGATTGTATTTGTCCCAGGGTGTTCCATACCATTAACCATAG
TAAAATCAGATGGAGGTTATACCTATGATACATCTGACCTGGCTGCTATTAAACAAAGACTATTTGAGGAAAAAGCAGATATGATTATCT
ATGTTGTGGACAATGGACAATCTGTGCACTTCCAGACAATATTTGCTGCTGCTCAAATGATTGGTTGGTATGACCCTAAAGTAACTCGAG
TCTTCCATGCTGGATTTGGTGTGGTGCTAGGGGAAGACAAGAAAAAGTTTAAAACACGTTCGGGTGAAACAGTGCGCCTCATGGATCTTC
TGGGAGAAGGACTAAAACGATCCATGGACAAGTTGAAGGAAAAAGAAAGAGACAAGGTCTTAACTGCAGAGGAATTGAATGCTGCTCAGA
CATCCGTTGCGTATGGCTGCATCAAATATGCTGACCTTTCCCATAACCGGTTGAATGACTACATCTTCTCCTTTGACAAAATGCTAGATG
ACAGAGGAAATACAGCTGCTTACTTGTTGTATGCCTTCACTAGAATCAGGTCTATTGCACGTCTGGCCAATATTGATGAAGAAATGCTCC
AAAAAGCTGCTCGAGAAACCAAGATTCTTTTGGATCATGAGAAGGAATGGAAACTAGGCCGGTGCATTTTACGGTTCCCTGAGATTCTGC
AAAAGATTTTAGATGACTTATTTCTCCACACTCTCTGTGATTATATATATGAGCTGGCAACTGCTTTCACAGAGTTCTATGATAGCTGCT
ACTGTGTGGAGAAAGATAGACAGACTGGAAAAATATTGAAGGTGAACATGTGGCGTATGCTGCTATGTGAAGCAGTAGCTGCTGTCATGG
CCAAGGGGTTTGATATCCTGGGAATAAAACCTGTCCAAAGGATGTAATCCTTCATAGGTTTGAACACTGTGTGTTTTTACCAAAGTGGCC

>51876_51876_2_MAT2B-RARS_MAT2B_chr5_162939202_ENST00000280969_RARS_chr5_167927595_ENST00000538719_length(amino acids)=461AA_BP=74
MPEMPEDMEQEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQESKKRFDTEEEFKKR
AYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPGCSIPLTIVKSD
GGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEG
LKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQKAA
RETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGF

--------------------------------------------------------------
>51876_51876_3_MAT2B-RARS_MAT2B_chr5_162939202_ENST00000321757_RARS_chr5_167927595_ENST00000231572_length(transcript)=1667nt_BP=397nt
GCAGCGGAAGCCGGAAGCGGCGAGCGGGGTCGTTCTGGGCCTAGGGGAGGCGGGCCGAGGGCGTCTGAGCTGAGGCCCGCGTCGATCCTG
GGTTGGAGGAGGTGGCGGCCGCTGAGGCTGCGGCGTGAAGACGGCGGGCATGGTGGGGCGGGAGAAAGAGCTCTCTATACACTTTGTTCC
CGGGAGCTGTCGGCTGGTGGAGGAGGAAGTTAACATCCCTAATAGGAGGGTTCTGGTTACTGGTGCCACTGGGCTTCTTGGCAGAGCTGT
ACACAAAGAATTTCAGCAGAATAATTGGCATGCAGTTGGCTGTGGTTTCAGAAGAGCAAGACCAAAATTTGAACAGGTTAATCTGTTGGA
TTCTAATGCAGTTCATCACATCATTCATGATTTTCAGGAATCTAAGAAGAGGTTTGATACTGAGGAGGAATTTAAGAAGCGAGCATATCA
GTGTGTAGTTCTGCTCCAGGGTAAAAACCCAGATATTACAAAAGCTTGGAAGCTTATCTGTGATGTCTCCCGCCAAGAGTTAAATAAAAT
CTATGATGCATTGGACGTCTCTTTAATAGAGAGAGGGGAATCCTTCTATCAAGATAGGATGAATGATATTGTAAAGGAATTTGAAGATAG
AGGATTTGTGCAGGTGGATGATGGCAGAAAGATTGTATTTGTCCCAGGGTGTTCCATACCATTAACCATAGTAAAATCAGATGGAGGTTA
TACCTATGATACATCTGACCTGGCTGCTATTAAACAAAGACTATTTGAGGAAAAAGCAGATATGATTATCTATGTTGTGGACAATGGACA
ATCTGTGCACTTCCAGACAATATTTGCTGCTGCTCAAATGATTGGTTGGTATGACCCTAAAGTAACTCGAGTCTTCCATGCTGGATTTGG
TGTGGTGCTAGGGGAAGACAAGAAAAAGTTTAAAACACGTTCGGGTGAAACAGTGCGCCTCATGGATCTTCTGGGAGAAGGACTAAAACG
ATCCATGGACAAGTTGAAGGAAAAAGAAAGAGACAAGGTCTTAACTGCAGAGGAATTGAATGCTGCTCAGACATCCGTTGCGTATGGCTG
CATCAAATATGCTGACCTTTCCCATAACCGGTTGAATGACTACATCTTCTCCTTTGACAAAATGCTAGATGACAGAGGAAATACAGCTGC
TTACTTGTTGTATGCCTTCACTAGAATCAGGTCTATTGCACGTCTGGCCAATATTGATGAAGAAATGCTCCAAAAAGCTGCTCGAGAAAC
CAAGATTCTTTTGGATCATGAGAAGGAATGGAAACTAGGCCGGTGCATTTTACGGTTCCCTGAGATTCTGCAAAAGATTTTAGATGACTT
ATTTCTCCACACTCTCTGTGATTATATATATGAGCTGGCAACTGCTTTCACAGAGTTCTATGATAGCTGCTACTGTGTGGAGAAAGATAG
ACAGACTGGAAAAATATTGAAGGTGAACATGTGGCGTATGCTGCTATGTGAAGCAGTAGCTGCTGTCATGGCCAAGGGGTTTGATATCCT
GGGAATAAAACCTGTCCAAAGGATGTAATCCTTCATAGGTTTGAACACTGTGTGTTTTTACCAAAGTGGCCATTGGCACTGTTTGCTTTT

>51876_51876_3_MAT2B-RARS_MAT2B_chr5_162939202_ENST00000321757_RARS_chr5_167927595_ENST00000231572_length(amino acids)=472AA_BP=85
MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQESKK
RFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPG
CSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGE
TVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLA
NIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLC

--------------------------------------------------------------
>51876_51876_4_MAT2B-RARS_MAT2B_chr5_162939202_ENST00000321757_RARS_chr5_167927595_ENST00000538719_length(transcript)=1666nt_BP=397nt
GCAGCGGAAGCCGGAAGCGGCGAGCGGGGTCGTTCTGGGCCTAGGGGAGGCGGGCCGAGGGCGTCTGAGCTGAGGCCCGCGTCGATCCTG
GGTTGGAGGAGGTGGCGGCCGCTGAGGCTGCGGCGTGAAGACGGCGGGCATGGTGGGGCGGGAGAAAGAGCTCTCTATACACTTTGTTCC
CGGGAGCTGTCGGCTGGTGGAGGAGGAAGTTAACATCCCTAATAGGAGGGTTCTGGTTACTGGTGCCACTGGGCTTCTTGGCAGAGCTGT
ACACAAAGAATTTCAGCAGAATAATTGGCATGCAGTTGGCTGTGGTTTCAGAAGAGCAAGACCAAAATTTGAACAGGTTAATCTGTTGGA
TTCTAATGCAGTTCATCACATCATTCATGATTTTCAGGAATCTAAGAAGAGGTTTGATACTGAGGAGGAATTTAAGAAGCGAGCATATCA
GTGTGTAGTTCTGCTCCAGGGTAAAAACCCAGATATTACAAAAGCTTGGAAGCTTATCTGTGATGTCTCCCGCCAAGAGTTAAATAAAAT
CTATGATGCATTGGACGTCTCTTTAATAGAGAGAGGGGAATCCTTCTATCAAGATAGGATGAATGATATTGTAAAGGAATTTGAAGATAG
AGGATTTGTGCAGGTGGATGATGGCAGAAAGATTGTATTTGTCCCAGGGTGTTCCATACCATTAACCATAGTAAAATCAGATGGAGGTTA
TACCTATGATACATCTGACCTGGCTGCTATTAAACAAAGACTATTTGAGGAAAAAGCAGATATGATTATCTATGTTGTGGACAATGGACA
ATCTGTGCACTTCCAGACAATATTTGCTGCTGCTCAAATGATTGGTTGGTATGACCCTAAAGTAACTCGAGTCTTCCATGCTGGATTTGG
TGTGGTGCTAGGGGAAGACAAGAAAAAGTTTAAAACACGTTCGGGTGAAACAGTGCGCCTCATGGATCTTCTGGGAGAAGGACTAAAACG
ATCCATGGACAAGTTGAAGGAAAAAGAAAGAGACAAGGTCTTAACTGCAGAGGAATTGAATGCTGCTCAGACATCCGTTGCGTATGGCTG
CATCAAATATGCTGACCTTTCCCATAACCGGTTGAATGACTACATCTTCTCCTTTGACAAAATGCTAGATGACAGAGGAAATACAGCTGC
TTACTTGTTGTATGCCTTCACTAGAATCAGGTCTATTGCACGTCTGGCCAATATTGATGAAGAAATGCTCCAAAAAGCTGCTCGAGAAAC
CAAGATTCTTTTGGATCATGAGAAGGAATGGAAACTAGGCCGGTGCATTTTACGGTTCCCTGAGATTCTGCAAAAGATTTTAGATGACTT
ATTTCTCCACACTCTCTGTGATTATATATATGAGCTGGCAACTGCTTTCACAGAGTTCTATGATAGCTGCTACTGTGTGGAGAAAGATAG
ACAGACTGGAAAAATATTGAAGGTGAACATGTGGCGTATGCTGCTATGTGAAGCAGTAGCTGCTGTCATGGCCAAGGGGTTTGATATCCT
GGGAATAAAACCTGTCCAAAGGATGTAATCCTTCATAGGTTTGAACACTGTGTGTTTTTACCAAAGTGGCCATTGGCACTGTTTGCTTTT

>51876_51876_4_MAT2B-RARS_MAT2B_chr5_162939202_ENST00000321757_RARS_chr5_167927595_ENST00000538719_length(amino acids)=472AA_BP=85
MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQESKK
RFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPG
CSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGE
TVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLA
NIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLC

--------------------------------------------------------------
>51876_51876_5_MAT2B-RARS_MAT2B_chr5_162939202_ENST00000518095_RARS_chr5_167927595_ENST00000231572_length(transcript)=1601nt_BP=331nt
GAGCTGAGGCCCGCGTCGATCCTGGGTTGGAGGAGGTGGCGGCCGCTGAGGCTGCGGCGTGAAGACGGCGGGCATGGTGGGGCGGGAGAA
AGAGCTCTCTATACACTTTGTTCCCGGGAGCTGTCGGCTGGTGGAGGAGGAAGTTAACATCCCTAATAGGAGGGTTCTGGTTACTGGTGC
CACTGGGCTTCTTGGCAGAGCTGTACACAAAGAATTTCAGCAGAATAATTGGCATGCAGTTGGCTGTGGTTTCAGAAGAGCAAGACCAAA
ATTTGAACAGGTTAATCTGTTGGATTCTAATGCAGTTCATCACATCATTCATGATTTTCAGGAATCTAAGAAGAGGTTTGATACTGAGGA
GGAATTTAAGAAGCGAGCATATCAGTGTGTAGTTCTGCTCCAGGGTAAAAACCCAGATATTACAAAAGCTTGGAAGCTTATCTGTGATGT
CTCCCGCCAAGAGTTAAATAAAATCTATGATGCATTGGACGTCTCTTTAATAGAGAGAGGGGAATCCTTCTATCAAGATAGGATGAATGA
TATTGTAAAGGAATTTGAAGATAGAGGATTTGTGCAGGTGGATGATGGCAGAAAGATTGTATTTGTCCCAGGGTGTTCCATACCATTAAC
CATAGTAAAATCAGATGGAGGTTATACCTATGATACATCTGACCTGGCTGCTATTAAACAAAGACTATTTGAGGAAAAAGCAGATATGAT
TATCTATGTTGTGGACAATGGACAATCTGTGCACTTCCAGACAATATTTGCTGCTGCTCAAATGATTGGTTGGTATGACCCTAAAGTAAC
TCGAGTCTTCCATGCTGGATTTGGTGTGGTGCTAGGGGAAGACAAGAAAAAGTTTAAAACACGTTCGGGTGAAACAGTGCGCCTCATGGA
TCTTCTGGGAGAAGGACTAAAACGATCCATGGACAAGTTGAAGGAAAAAGAAAGAGACAAGGTCTTAACTGCAGAGGAATTGAATGCTGC
TCAGACATCCGTTGCGTATGGCTGCATCAAATATGCTGACCTTTCCCATAACCGGTTGAATGACTACATCTTCTCCTTTGACAAAATGCT
AGATGACAGAGGAAATACAGCTGCTTACTTGTTGTATGCCTTCACTAGAATCAGGTCTATTGCACGTCTGGCCAATATTGATGAAGAAAT
GCTCCAAAAAGCTGCTCGAGAAACCAAGATTCTTTTGGATCATGAGAAGGAATGGAAACTAGGCCGGTGCATTTTACGGTTCCCTGAGAT
TCTGCAAAAGATTTTAGATGACTTATTTCTCCACACTCTCTGTGATTATATATATGAGCTGGCAACTGCTTTCACAGAGTTCTATGATAG
CTGCTACTGTGTGGAGAAAGATAGACAGACTGGAAAAATATTGAAGGTGAACATGTGGCGTATGCTGCTATGTGAAGCAGTAGCTGCTGT
CATGGCCAAGGGGTTTGATATCCTGGGAATAAAACCTGTCCAAAGGATGTAATCCTTCATAGGTTTGAACACTGTGTGTTTTTACCAAAG

>51876_51876_5_MAT2B-RARS_MAT2B_chr5_162939202_ENST00000518095_RARS_chr5_167927595_ENST00000231572_length(amino acids)=472AA_BP=85
MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQESKK
RFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPG
CSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGE
TVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLA
NIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLC

--------------------------------------------------------------
>51876_51876_6_MAT2B-RARS_MAT2B_chr5_162939202_ENST00000518095_RARS_chr5_167927595_ENST00000538719_length(transcript)=1600nt_BP=331nt
GAGCTGAGGCCCGCGTCGATCCTGGGTTGGAGGAGGTGGCGGCCGCTGAGGCTGCGGCGTGAAGACGGCGGGCATGGTGGGGCGGGAGAA
AGAGCTCTCTATACACTTTGTTCCCGGGAGCTGTCGGCTGGTGGAGGAGGAAGTTAACATCCCTAATAGGAGGGTTCTGGTTACTGGTGC
CACTGGGCTTCTTGGCAGAGCTGTACACAAAGAATTTCAGCAGAATAATTGGCATGCAGTTGGCTGTGGTTTCAGAAGAGCAAGACCAAA
ATTTGAACAGGTTAATCTGTTGGATTCTAATGCAGTTCATCACATCATTCATGATTTTCAGGAATCTAAGAAGAGGTTTGATACTGAGGA
GGAATTTAAGAAGCGAGCATATCAGTGTGTAGTTCTGCTCCAGGGTAAAAACCCAGATATTACAAAAGCTTGGAAGCTTATCTGTGATGT
CTCCCGCCAAGAGTTAAATAAAATCTATGATGCATTGGACGTCTCTTTAATAGAGAGAGGGGAATCCTTCTATCAAGATAGGATGAATGA
TATTGTAAAGGAATTTGAAGATAGAGGATTTGTGCAGGTGGATGATGGCAGAAAGATTGTATTTGTCCCAGGGTGTTCCATACCATTAAC
CATAGTAAAATCAGATGGAGGTTATACCTATGATACATCTGACCTGGCTGCTATTAAACAAAGACTATTTGAGGAAAAAGCAGATATGAT
TATCTATGTTGTGGACAATGGACAATCTGTGCACTTCCAGACAATATTTGCTGCTGCTCAAATGATTGGTTGGTATGACCCTAAAGTAAC
TCGAGTCTTCCATGCTGGATTTGGTGTGGTGCTAGGGGAAGACAAGAAAAAGTTTAAAACACGTTCGGGTGAAACAGTGCGCCTCATGGA
TCTTCTGGGAGAAGGACTAAAACGATCCATGGACAAGTTGAAGGAAAAAGAAAGAGACAAGGTCTTAACTGCAGAGGAATTGAATGCTGC
TCAGACATCCGTTGCGTATGGCTGCATCAAATATGCTGACCTTTCCCATAACCGGTTGAATGACTACATCTTCTCCTTTGACAAAATGCT
AGATGACAGAGGAAATACAGCTGCTTACTTGTTGTATGCCTTCACTAGAATCAGGTCTATTGCACGTCTGGCCAATATTGATGAAGAAAT
GCTCCAAAAAGCTGCTCGAGAAACCAAGATTCTTTTGGATCATGAGAAGGAATGGAAACTAGGCCGGTGCATTTTACGGTTCCCTGAGAT
TCTGCAAAAGATTTTAGATGACTTATTTCTCCACACTCTCTGTGATTATATATATGAGCTGGCAACTGCTTTCACAGAGTTCTATGATAG
CTGCTACTGTGTGGAGAAAGATAGACAGACTGGAAAAATATTGAAGGTGAACATGTGGCGTATGCTGCTATGTGAAGCAGTAGCTGCTGT
CATGGCCAAGGGGTTTGATATCCTGGGAATAAAACCTGTCCAAAGGATGTAATCCTTCATAGGTTTGAACACTGTGTGTTTTTACCAAAG

>51876_51876_6_MAT2B-RARS_MAT2B_chr5_162939202_ENST00000518095_RARS_chr5_167927595_ENST00000538719_length(amino acids)=472AA_BP=85
MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQESKK
RFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPG
CSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGE
TVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLA
NIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MAT2B-RARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRARSchr5:162939202chr5:167927595ENST00000231572615529_543274.0661.0tRNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAT2B-RARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAT2B-RARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource