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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MATN2-LAPTM4B (FusionGDB2 ID:51880)

Fusion Gene Summary for MATN2-LAPTM4B

check button Fusion gene summary
Fusion gene informationFusion gene name: MATN2-LAPTM4B
Fusion gene ID: 51880
HgeneTgene
Gene symbol

MATN2

LAPTM4B

Gene ID

4147

55353

Gene namematrilin 2lysosomal protein transmembrane 4 beta
Synonyms-LAPTM4beta|LC27
Cytomap

8q22.1-q22.2

8q22.1

Type of geneprotein-codingprotein-coding
Descriptionmatrilin-2testis tissue sperm-binding protein Li 94mPlysosomal-associated transmembrane protein 4Blysosomal associated protein transmembrane 4 betalysosome-associated transmembrane protein 4-beta
Modification date2020031320200313
UniProtAcc

O00339

Q86VI4

Ensembl transtripts involved in fusion geneENST00000522025, ENST00000254898, 
ENST00000520016, ENST00000521689, 
ENST00000524308, ENST00000518238, 
ENST00000445593, ENST00000521545, 
Fusion gene scores* DoF score5 X 7 X 7=24514 X 8 X 8=896
# samples 716
** MAII scorelog2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/896*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MATN2 [Title/Abstract] AND LAPTM4B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMATN2(99019829)-LAPTM4B(98863625), # samples:3
LAPTM4B(98788336)-MATN2(98943181), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLAPTM4B

GO:0032509

endosome transport via multivesicular body sorting pathway

25588945

TgeneLAPTM4B

GO:0032911

negative regulation of transforming growth factor beta1 production

26126825


check buttonFusion gene breakpoints across MATN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LAPTM4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DS-A3LQ-01AMATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
ChimerDB4LIHCTCGA-BD-A3ER-01AMATN2chr8

99019829

-LAPTM4Bchr8

98863625

+
ChimerDB4LIHCTCGA-BD-A3ER-01AMATN2chr8

99019829

+LAPTM4Bchr8

98863625

+


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Fusion Gene ORF analysis for MATN2-LAPTM4B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000522025ENST00000445593MATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
5UTR-3CDSENST00000522025ENST00000521545MATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
Frame-shiftENST00000254898ENST00000445593MATN2chr8

99019829

+LAPTM4Bchr8

98863625

+
Frame-shiftENST00000254898ENST00000521545MATN2chr8

99019829

+LAPTM4Bchr8

98863625

+
Frame-shiftENST00000520016ENST00000445593MATN2chr8

99019829

+LAPTM4Bchr8

98863625

+
Frame-shiftENST00000520016ENST00000521545MATN2chr8

99019829

+LAPTM4Bchr8

98863625

+
Frame-shiftENST00000521689ENST00000445593MATN2chr8

99019829

+LAPTM4Bchr8

98863625

+
Frame-shiftENST00000521689ENST00000521545MATN2chr8

99019829

+LAPTM4Bchr8

98863625

+
Frame-shiftENST00000522025ENST00000445593MATN2chr8

99019829

+LAPTM4Bchr8

98863625

+
Frame-shiftENST00000522025ENST00000521545MATN2chr8

99019829

+LAPTM4Bchr8

98863625

+
Frame-shiftENST00000524308ENST00000445593MATN2chr8

99019829

+LAPTM4Bchr8

98863625

+
Frame-shiftENST00000524308ENST00000521545MATN2chr8

99019829

+LAPTM4Bchr8

98863625

+
In-frameENST00000254898ENST00000445593MATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
In-frameENST00000254898ENST00000521545MATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
In-frameENST00000520016ENST00000445593MATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
In-frameENST00000520016ENST00000521545MATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
In-frameENST00000521689ENST00000445593MATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
In-frameENST00000521689ENST00000521545MATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
In-frameENST00000524308ENST00000445593MATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
In-frameENST00000524308ENST00000521545MATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
intron-3CDSENST00000518238ENST00000445593MATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
intron-3CDSENST00000518238ENST00000445593MATN2chr8

99019829

+LAPTM4Bchr8

98863625

+
intron-3CDSENST00000518238ENST00000521545MATN2chr8

98954127

+LAPTM4Bchr8

98827556

+
intron-3CDSENST00000518238ENST00000521545MATN2chr8

99019829

+LAPTM4Bchr8

98863625

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000521689MATN2chr898954127+ENST00000445593LAPTM4Bchr898827556+3318130991778589
ENST00000521689MATN2chr898954127+ENST00000521545LAPTM4Bchr898827556+1779130991778589
ENST00000254898MATN2chr898954127+ENST00000445593LAPTM4Bchr898827556+30751066181535505
ENST00000254898MATN2chr898954127+ENST00000521545LAPTM4Bchr898827556+15361066181535505
ENST00000524308MATN2chr898954127+ENST00000445593LAPTM4Bchr898827556+3047103821507501
ENST00000524308MATN2chr898954127+ENST00000521545LAPTM4Bchr898827556+1508103821507502
ENST00000520016MATN2chr898954127+ENST00000445593LAPTM4Bchr898827556+2968959671428453
ENST00000520016MATN2chr898954127+ENST00000521545LAPTM4Bchr898827556+1429959671428454

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000521689ENST00000445593MATN2chr898954127+LAPTM4Bchr898827556+0.0003753540.9996246
ENST00000521689ENST00000521545MATN2chr898954127+LAPTM4Bchr898827556+0.002228480.9977715
ENST00000254898ENST00000445593MATN2chr898954127+LAPTM4Bchr898827556+0.0002375150.9997625
ENST00000254898ENST00000521545MATN2chr898954127+LAPTM4Bchr898827556+0.0013433820.99865663
ENST00000524308ENST00000445593MATN2chr898954127+LAPTM4Bchr898827556+0.0002160420.99978393
ENST00000524308ENST00000521545MATN2chr898954127+LAPTM4Bchr898827556+0.001015860.99898416
ENST00000520016ENST00000445593MATN2chr898954127+LAPTM4Bchr898827556+0.000165470.99983454
ENST00000520016ENST00000521545MATN2chr898954127+LAPTM4Bchr898827556+0.0006856250.9993144

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Fusion Genomic Features for MATN2-LAPTM4B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MATN2-LAPTM4B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:99019829/chr8:98863625)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MATN2

O00339

LAPTM4B

Q86VI4

FUNCTION: Involved in matrix assembly. {ECO:0000250}.FUNCTION: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656). {ECO:0000269|PubMed:21224396, ECO:0000269|PubMed:25588945, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:26126825, ECO:0000269|PubMed:26280656}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMATN2chr8:98954127chr8:98827556ENST00000520016+318238_278278957.0DomainEGF-like 1
HgeneMATN2chr8:98954127chr8:98827556ENST00000520016+31857_232278957.0DomainVWFA 1
HgeneMATN2chr8:98954127chr8:98827556ENST00000521689+419238_278278938.0DomainEGF-like 1
HgeneMATN2chr8:98954127chr8:98827556ENST00000521689+41957_232278938.0DomainVWFA 1
HgeneMATN2chr8:98954127chr8:98827556ENST00000524308+418238_278278916.0DomainEGF-like 1
HgeneMATN2chr8:98954127chr8:98827556ENST00000524308+41857_232278916.0DomainVWFA 1
TgeneLAPTM4Bchr8:98954127chr8:98827556ENST0000044559317163_183161318.0TransmembraneHelical
TgeneLAPTM4Bchr8:98954127chr8:98827556ENST0000044559317191_211161318.0TransmembraneHelical
TgeneLAPTM4Bchr8:98954127chr8:98827556ENST0000044559317244_264161318.0TransmembraneHelical
TgeneLAPTM4Bchr8:98954127chr8:98827556ENST0000052154517117_13770227.0TransmembraneHelical
TgeneLAPTM4Bchr8:98954127chr8:98827556ENST0000052154517163_18370227.0TransmembraneHelical
TgeneLAPTM4Bchr8:98954127chr8:98827556ENST0000052154517191_21170227.0TransmembraneHelical
TgeneLAPTM4Bchr8:98954127chr8:98827556ENST0000052154517244_26470227.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMATN2chr8:98954127chr8:98827556ENST00000520016+318917_955278957.0Coiled coilOntology_term=ECO:0000255
HgeneMATN2chr8:98954127chr8:98827556ENST00000521689+419917_955278938.0Coiled coilOntology_term=ECO:0000255
HgeneMATN2chr8:98954127chr8:98827556ENST00000522025+318917_9550673.0Coiled coilOntology_term=ECO:0000255
HgeneMATN2chr8:98954127chr8:98827556ENST00000524308+418917_955278916.0Coiled coilOntology_term=ECO:0000255
HgeneMATN2chr8:98954127chr8:98827556ENST00000520016+318279_319278957.0DomainEGF-like 2
HgeneMATN2chr8:98954127chr8:98827556ENST00000520016+318320_360278957.0DomainEGF-like 3
HgeneMATN2chr8:98954127chr8:98827556ENST00000520016+318402_442278957.0DomainEGF-like 5
HgeneMATN2chr8:98954127chr8:98827556ENST00000520016+318443_483278957.0DomainEGF-like 6
HgeneMATN2chr8:98954127chr8:98827556ENST00000520016+318484_524278957.0DomainEGF-like 7
HgeneMATN2chr8:98954127chr8:98827556ENST00000520016+318525_565278957.0DomainEGF-like 8
HgeneMATN2chr8:98954127chr8:98827556ENST00000520016+318566_606278957.0DomainEGF-like 9
HgeneMATN2chr8:98954127chr8:98827556ENST00000520016+318607_647278957.0DomainEGF-like 10
HgeneMATN2chr8:98954127chr8:98827556ENST00000520016+318655_830278957.0DomainVWFA 2
HgeneMATN2chr8:98954127chr8:98827556ENST00000521689+419279_319278938.0DomainEGF-like 2
HgeneMATN2chr8:98954127chr8:98827556ENST00000521689+419320_360278938.0DomainEGF-like 3
HgeneMATN2chr8:98954127chr8:98827556ENST00000521689+419402_442278938.0DomainEGF-like 5
HgeneMATN2chr8:98954127chr8:98827556ENST00000521689+419443_483278938.0DomainEGF-like 6
HgeneMATN2chr8:98954127chr8:98827556ENST00000521689+419484_524278938.0DomainEGF-like 7
HgeneMATN2chr8:98954127chr8:98827556ENST00000521689+419525_565278938.0DomainEGF-like 8
HgeneMATN2chr8:98954127chr8:98827556ENST00000521689+419566_606278938.0DomainEGF-like 9
HgeneMATN2chr8:98954127chr8:98827556ENST00000521689+419607_647278938.0DomainEGF-like 10
HgeneMATN2chr8:98954127chr8:98827556ENST00000521689+419655_830278938.0DomainVWFA 2
HgeneMATN2chr8:98954127chr8:98827556ENST00000522025+318238_2780673.0DomainEGF-like 1
HgeneMATN2chr8:98954127chr8:98827556ENST00000522025+318279_3190673.0DomainEGF-like 2
HgeneMATN2chr8:98954127chr8:98827556ENST00000522025+318320_3600673.0DomainEGF-like 3
HgeneMATN2chr8:98954127chr8:98827556ENST00000522025+318402_4420673.0DomainEGF-like 5
HgeneMATN2chr8:98954127chr8:98827556ENST00000522025+318443_4830673.0DomainEGF-like 6
HgeneMATN2chr8:98954127chr8:98827556ENST00000522025+318484_5240673.0DomainEGF-like 7
HgeneMATN2chr8:98954127chr8:98827556ENST00000522025+318525_5650673.0DomainEGF-like 8
HgeneMATN2chr8:98954127chr8:98827556ENST00000522025+318566_6060673.0DomainEGF-like 9
HgeneMATN2chr8:98954127chr8:98827556ENST00000522025+31857_2320673.0DomainVWFA 1
HgeneMATN2chr8:98954127chr8:98827556ENST00000522025+318607_6470673.0DomainEGF-like 10
HgeneMATN2chr8:98954127chr8:98827556ENST00000522025+318655_8300673.0DomainVWFA 2
HgeneMATN2chr8:98954127chr8:98827556ENST00000524308+418279_319278916.0DomainEGF-like 2
HgeneMATN2chr8:98954127chr8:98827556ENST00000524308+418320_360278916.0DomainEGF-like 3
HgeneMATN2chr8:98954127chr8:98827556ENST00000524308+418402_442278916.0DomainEGF-like 5
HgeneMATN2chr8:98954127chr8:98827556ENST00000524308+418443_483278916.0DomainEGF-like 6
HgeneMATN2chr8:98954127chr8:98827556ENST00000524308+418484_524278916.0DomainEGF-like 7
HgeneMATN2chr8:98954127chr8:98827556ENST00000524308+418525_565278916.0DomainEGF-like 8
HgeneMATN2chr8:98954127chr8:98827556ENST00000524308+418566_606278916.0DomainEGF-like 9
HgeneMATN2chr8:98954127chr8:98827556ENST00000524308+418607_647278916.0DomainEGF-like 10
HgeneMATN2chr8:98954127chr8:98827556ENST00000524308+418655_830278916.0DomainVWFA 2
TgeneLAPTM4Bchr8:98954127chr8:98827556ENST0000044559317117_137161318.0TransmembraneHelical


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Fusion Gene Sequence for MATN2-LAPTM4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51880_51880_1_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000254898_LAPTM4B_chr8_98827556_ENST00000445593_length(transcript)=3075nt_BP=1066nt
GCGAGCGAAGGGAGCGCTCTGGGATGGGACTTGGAGCAAGCGGCGGCGGCGGAGACAGAGGCAGAGGCAGAAGCTGGGGCTCCGTCCTCG
CCTCCCACGAGCGATCCCCGAGGAGAGCCGCGGCCCTCGGCGAGGCGAAGAGGCCGACGAGGAAGACCCGGGTGGCTGCGCCCCTGCCTC
GCTTCCCAGGCGCCGGCGGCTGCAGCCTTGCCCCTCTTGCTCGCCTTGAAAATGGAAAAGATGCTCGCAGGCTGCTTTCTGCTGATCCTC
GGACAGATCGTCCTCCTCCCTGCCGAGGCCAGGGAGCGGTCACGTGGGAGGTCCATCTCTAGGGGCAGACACGCTCGGACCCACCCGCAG
ACGGCCCTTCTGGAGAGTTCCTGTGAGAACAAGCGGGCAGACCTGGTTTTCATCATTGACAGCTCTCGCAGTGTCAACACCCATGACTAT
GCAAAGGTCAAGGAGTTCATCGTGGACATCTTGCAATTCTTGGACATTGGTCCTGATGTCACCCGAGTGGGCCTGCTCCAATATGGCAGC
ACTGTCAAGAATGAGTTCTCCCTCAAGACCTTCAAGAGGAAGTCCGAGGTGGAGCGTGCTGTCAAGAGGATGCGGCATCTGTCCACGGGC
ACCATGACTGGGCTGGCCATCCAGTATGCCCTGAACATCGCATTCTCAGAAGCAGAGGGGGCCCGGCCCCTGAGGGAGAATGTGCCACGG
GTCATAATGATCGTGACAGATGGGAGACCTCAGGACTCCGTGGCCGAGGTGGCTGCTAAGGCACGGGACACGGGCATCCTAATCTTTGCC
ATTGGTGTGGGCCAGGTAGACTTCAACACCTTGAAGTCCATTGGGAGTGAGCCCCATGAGGACCATGTCTTCCTTGTGGCCAATTTCAGC
CAGATTGAGACGCTGACCTCCGTGTTCCAGAAGAAGTTGTGCACGGCCCATATGTGCAGCACCCTGGAGCATAACTGTGCCCACTTCTGC
ATCAACATCCCTGGCTCATACGTCTGCAGGTGCAAACAAGGCTACATTCTCAACTCGGATCAGACGACTTGCAGAAACATGTGCATTGCC
ATTGCGATTTCTCTTCTCATGATCCTGATATGTGCTATGGCTACTTACGGAGCGTACAAGCAACGCGCAGCCTGGATCATCCCATTCTTC
TGTTACCAGATCTTTGACTTTGCCCTGAACATGTTGGTTGCAATCACTGTGCTTATTTATCCAAACTCCATTCAGGAATACATACGGCAA
CTGCCTCCTAATTTTCCCTACAGAGATGATGTCATGTCAGTGAATCCTACCTGTTTGGTCCTTATTATTCTTCTGTTTATTAGCATTATC
TTGACTTTTAAGGGTTACTTGATTAGCTGTGTTTGGAACTGCTACCGATACATCAATGGTAGGAACTCCTCTGATGTCCTGGTTTATGTT
ACCAGCAATGACACTACGGTGCTGCTACCCCCGTATGATGATGCCACTGTGAATGGTGCTGCCAAGGAGCCACCGCCACCTTACGTGTCT
GCCTAAGCCTTCAAGTGGGCGGAGCTGAGGGCAGCAGCTTGACTTTGCAGACATCTGAGCAATAGTTCTGTTATTTCACTTTTGCCATGA
GCCTCTCTGAGCTTGTTTGTTGCTGAAATGCTACTTTTTAAAATTTAGATGTTAGATTGAAAACTGTAGTTTTCAACATATGCTTTGCTG
GAACACTGTGATAGATTAACTGTAGAATTCTTCCTGTACGATTGGGGATATAATGGGCTTCACTAACCTTCCCTAGGCATTGAAACTTCC
CCCAAATCTGATGGACCTAGAAGTCTGCTTTTGTACCTGCTGGGCCCCAAAGTTGGGCATTTTTCTCTCTGTTCCCTCTCTTTTGAAAAT
GTAAAATAAAACCAAAAATAGACAACTTTTTCTTCAGCCATTCCAGCATAGAGAACAAAACCTTATGGAAACAGGAATGTCAATTGTGTA
ATCATTGTTCTAATTAGGTAAATAGAAGTCCTTATGTATGTGTTACAAGAATTTCCCCCACAACATCCTTTATGACTGAAGTTCAATGAC
AGTTTGTGTTTGGTGGTAAAGGATTTTCTCCATGGCCTGAATTAAGACCATTAGAAAGCACCAGGCCGTGGGAGCAGTGACCATCTGCTG
ACTGTTCTTGTGGATCTTGTGTCCAGGGACATGGGGTGACATGCCTCGTATGTGTTAGAGGGTGGAATGGATGTGTTTGGCGCTGCATGG
GATCTGGTGCCCCTCTTCTCCTGGATTCACATCCCCACCCAGGGCCCGCTTTTACTAAGTGTTCTGCCCTAGATTGGTTCAAGGAGGTCA
TCCAACTGACTTTATCAAGTGGAATTGGGATATATTTGATATACTTCTGCCTAACAACATGGAAAAGGGTTTTCTTTTCCCTGCAAGCTA
CATCCTACTGCTTTGAACTTCCAAGTATGTCTAGTCACCTTTTAAAATGTAAACATTTTCAGAAAAATGAGGATTGCCTTCCTTGTATGC
GCTTTTTACCTTGACTACCTGAATTGCAAGGGATTTTTATATATTCATATGTTACAAAGTCAGCAACTCTCCTGTTGGTTCATTATTGAA
TGTGCTGTAAATTAAGTTGTTTGCAATTAAAACAAGGTTTGCCCACATCCAAGATGACCTTGTGATTTTGTGCTGATTGTGTCTGAGGAC
CTTTCCCTCCACATATGGTCTGGCAGATGCACCCAGTTCAGCCTAAGGAGTAGGCTTTTTTTTGGGGGGGGGAGGTCGGGTGGGGGGGAT
TTTTAATCTTTTAATTTTCAAGATGGTTAAAATATTGAAATGTTTAAGTGGATAACTATATTATTCATAAAATGACTGAGTGAAAACTAA
TACACTATGAGATGAAAAGTACTTGTCAGGGATTTTCAAGCTTTTGCTCAAGTAATTACTATGAAATAACAATTTCTAGAAATGAAGAAC
AATCCGTGGAGAATAAATTACCATTGGTGTGGGGGAAAAAAGCCAAACAGAAGTAGAAAAAGGTGTAGCCGGCATACAAATGTTATCTAC

>51880_51880_1_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000254898_LAPTM4B_chr8_98827556_ENST00000445593_length(amino acids)=505AA_BP=350
MGWDLEQAAAAETEAEAEAGAPSSPPTSDPRGEPRPSARRRGRRGRPGWLRPCLASQAPAAAALPLLLALKMEKMLAGCFLLILGQIVLL
PAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEF
SLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQV
DFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRNMCIAIAISLL
MILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGY

--------------------------------------------------------------
>51880_51880_2_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000254898_LAPTM4B_chr8_98827556_ENST00000521545_length(transcript)=1536nt_BP=1066nt
GCGAGCGAAGGGAGCGCTCTGGGATGGGACTTGGAGCAAGCGGCGGCGGCGGAGACAGAGGCAGAGGCAGAAGCTGGGGCTCCGTCCTCG
CCTCCCACGAGCGATCCCCGAGGAGAGCCGCGGCCCTCGGCGAGGCGAAGAGGCCGACGAGGAAGACCCGGGTGGCTGCGCCCCTGCCTC
GCTTCCCAGGCGCCGGCGGCTGCAGCCTTGCCCCTCTTGCTCGCCTTGAAAATGGAAAAGATGCTCGCAGGCTGCTTTCTGCTGATCCTC
GGACAGATCGTCCTCCTCCCTGCCGAGGCCAGGGAGCGGTCACGTGGGAGGTCCATCTCTAGGGGCAGACACGCTCGGACCCACCCGCAG
ACGGCCCTTCTGGAGAGTTCCTGTGAGAACAAGCGGGCAGACCTGGTTTTCATCATTGACAGCTCTCGCAGTGTCAACACCCATGACTAT
GCAAAGGTCAAGGAGTTCATCGTGGACATCTTGCAATTCTTGGACATTGGTCCTGATGTCACCCGAGTGGGCCTGCTCCAATATGGCAGC
ACTGTCAAGAATGAGTTCTCCCTCAAGACCTTCAAGAGGAAGTCCGAGGTGGAGCGTGCTGTCAAGAGGATGCGGCATCTGTCCACGGGC
ACCATGACTGGGCTGGCCATCCAGTATGCCCTGAACATCGCATTCTCAGAAGCAGAGGGGGCCCGGCCCCTGAGGGAGAATGTGCCACGG
GTCATAATGATCGTGACAGATGGGAGACCTCAGGACTCCGTGGCCGAGGTGGCTGCTAAGGCACGGGACACGGGCATCCTAATCTTTGCC
ATTGGTGTGGGCCAGGTAGACTTCAACACCTTGAAGTCCATTGGGAGTGAGCCCCATGAGGACCATGTCTTCCTTGTGGCCAATTTCAGC
CAGATTGAGACGCTGACCTCCGTGTTCCAGAAGAAGTTGTGCACGGCCCATATGTGCAGCACCCTGGAGCATAACTGTGCCCACTTCTGC
ATCAACATCCCTGGCTCATACGTCTGCAGGTGCAAACAAGGCTACATTCTCAACTCGGATCAGACGACTTGCAGAAACATGTGCATTGCC
ATTGCGATTTCTCTTCTCATGATCCTGATATGTGCTATGGCTACTTACGGAGCGTACAAGCAACGCGCAGCCTGGATCATCCCATTCTTC
TGTTACCAGATCTTTGACTTTGCCCTGAACATGTTGGTTGCAATCACTGTGCTTATTTATCCAAACTCCATTCAGGAATACATACGGCAA
CTGCCTCCTAATTTTCCCTACAGAGATGATGTCATGTCAGTGAATCCTACCTGTTTGGTCCTTATTATTCTTCTGTTTATTAGCATTATC
TTGACTTTTAAGGGTTACTTGATTAGCTGTGTTTGGAACTGCTACCGATACATCAATGGTAGGAACTCCTCTGATGTCCTGGTTTATGTT
ACCAGCAATGACACTACGGTGCTGCTACCCCCGTATGATGATGCCACTGTGAATGGTGCTGCCAAGGAGCCACCGCCACCTTACGTGTCT

>51880_51880_2_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000254898_LAPTM4B_chr8_98827556_ENST00000521545_length(amino acids)=505AA_BP=350
MGWDLEQAAAAETEAEAEAGAPSSPPTSDPRGEPRPSARRRGRRGRPGWLRPCLASQAPAAAALPLLLALKMEKMLAGCFLLILGQIVLL
PAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEF
SLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQV
DFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRNMCIAIAISLL
MILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGY

--------------------------------------------------------------
>51880_51880_3_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000520016_LAPTM4B_chr8_98827556_ENST00000445593_length(transcript)=2968nt_BP=959nt
GAACTCTGAAAAGGCGGGGCAGCGGGCCTGCAGCTCCTGGAGTTCAGGGAGACCCGGAAATCTCACCCTGCCCTCTTCTTGTGTTGTGTT
TGTCACAGCCTTGCCCCTCTTGCTCGCCTTGAAAATGGAAAAGATGCTCGCAGGCTGCTTTCTGCTGATCCTCGGACAGATCGTCCTCCT
CCCTGCCGAGGCCAGGGAGCGGTCACGTGGGAGGTCCATCTCTAGGGGCAGACACGCTCGGACCCACCCGCAGACGGCCCTTCTGGAGAG
TTCCTGTGAGAACAAGCGGGCAGACCTGGTTTTCATCATTGACAGCTCTCGCAGTGTCAACACCCATGACTATGCAAAGGTCAAGGAGTT
CATCGTGGACATCTTGCAATTCTTGGACATTGGTCCTGATGTCACCCGAGTGGGCCTGCTCCAATATGGCAGCACTGTCAAGAATGAGTT
CTCCCTCAAGACCTTCAAGAGGAAGTCCGAGGTGGAGCGTGCTGTCAAGAGGATGCGGCATCTGTCCACGGGCACCATGACTGGGCTGGC
CATCCAGTATGCCCTGAACATCGCATTCTCAGAAGCAGAGGGGGCCCGGCCCCTGAGGGAGAATGTGCCACGGGTCATAATGATCGTGAC
AGATGGGAGACCTCAGGACTCCGTGGCCGAGGTGGCTGCTAAGGCACGGGACACGGGCATCCTAATCTTTGCCATTGGTGTGGGCCAGGT
AGACTTCAACACCTTGAAGTCCATTGGGAGTGAGCCCCATGAGGACCATGTCTTCCTTGTGGCCAATTTCAGCCAGATTGAGACGCTGAC
CTCCGTGTTCCAGAAGAAGTTGTGCACGGCCCATATGTGCAGCACCCTGGAGCATAACTGTGCCCACTTCTGCATCAACATCCCTGGCTC
ATACGTCTGCAGGTGCAAACAAGGCTACATTCTCAACTCGGATCAGACGACTTGCAGAAACATGTGCATTGCCATTGCGATTTCTCTTCT
CATGATCCTGATATGTGCTATGGCTACTTACGGAGCGTACAAGCAACGCGCAGCCTGGATCATCCCATTCTTCTGTTACCAGATCTTTGA
CTTTGCCCTGAACATGTTGGTTGCAATCACTGTGCTTATTTATCCAAACTCCATTCAGGAATACATACGGCAACTGCCTCCTAATTTTCC
CTACAGAGATGATGTCATGTCAGTGAATCCTACCTGTTTGGTCCTTATTATTCTTCTGTTTATTAGCATTATCTTGACTTTTAAGGGTTA
CTTGATTAGCTGTGTTTGGAACTGCTACCGATACATCAATGGTAGGAACTCCTCTGATGTCCTGGTTTATGTTACCAGCAATGACACTAC
GGTGCTGCTACCCCCGTATGATGATGCCACTGTGAATGGTGCTGCCAAGGAGCCACCGCCACCTTACGTGTCTGCCTAAGCCTTCAAGTG
GGCGGAGCTGAGGGCAGCAGCTTGACTTTGCAGACATCTGAGCAATAGTTCTGTTATTTCACTTTTGCCATGAGCCTCTCTGAGCTTGTT
TGTTGCTGAAATGCTACTTTTTAAAATTTAGATGTTAGATTGAAAACTGTAGTTTTCAACATATGCTTTGCTGGAACACTGTGATAGATT
AACTGTAGAATTCTTCCTGTACGATTGGGGATATAATGGGCTTCACTAACCTTCCCTAGGCATTGAAACTTCCCCCAAATCTGATGGACC
TAGAAGTCTGCTTTTGTACCTGCTGGGCCCCAAAGTTGGGCATTTTTCTCTCTGTTCCCTCTCTTTTGAAAATGTAAAATAAAACCAAAA
ATAGACAACTTTTTCTTCAGCCATTCCAGCATAGAGAACAAAACCTTATGGAAACAGGAATGTCAATTGTGTAATCATTGTTCTAATTAG
GTAAATAGAAGTCCTTATGTATGTGTTACAAGAATTTCCCCCACAACATCCTTTATGACTGAAGTTCAATGACAGTTTGTGTTTGGTGGT
AAAGGATTTTCTCCATGGCCTGAATTAAGACCATTAGAAAGCACCAGGCCGTGGGAGCAGTGACCATCTGCTGACTGTTCTTGTGGATCT
TGTGTCCAGGGACATGGGGTGACATGCCTCGTATGTGTTAGAGGGTGGAATGGATGTGTTTGGCGCTGCATGGGATCTGGTGCCCCTCTT
CTCCTGGATTCACATCCCCACCCAGGGCCCGCTTTTACTAAGTGTTCTGCCCTAGATTGGTTCAAGGAGGTCATCCAACTGACTTTATCA
AGTGGAATTGGGATATATTTGATATACTTCTGCCTAACAACATGGAAAAGGGTTTTCTTTTCCCTGCAAGCTACATCCTACTGCTTTGAA
CTTCCAAGTATGTCTAGTCACCTTTTAAAATGTAAACATTTTCAGAAAAATGAGGATTGCCTTCCTTGTATGCGCTTTTTACCTTGACTA
CCTGAATTGCAAGGGATTTTTATATATTCATATGTTACAAAGTCAGCAACTCTCCTGTTGGTTCATTATTGAATGTGCTGTAAATTAAGT
TGTTTGCAATTAAAACAAGGTTTGCCCACATCCAAGATGACCTTGTGATTTTGTGCTGATTGTGTCTGAGGACCTTTCCCTCCACATATG
GTCTGGCAGATGCACCCAGTTCAGCCTAAGGAGTAGGCTTTTTTTTGGGGGGGGGAGGTCGGGTGGGGGGGATTTTTAATCTTTTAATTT
TCAAGATGGTTAAAATATTGAAATGTTTAAGTGGATAACTATATTATTCATAAAATGACTGAGTGAAAACTAATACACTATGAGATGAAA
AGTACTTGTCAGGGATTTTCAAGCTTTTGCTCAAGTAATTACTATGAAATAACAATTTCTAGAAATGAAGAACAATCCGTGGAGAATAAA

>51880_51880_3_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000520016_LAPTM4B_chr8_98827556_ENST00000445593_length(amino acids)=453AA_BP=298
MPSSCVVFVTALPLLLALKMEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTH
DYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENV
PRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAH
FCINIPGSYVCRCKQGYILNSDQTTCRNMCIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYI
RQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVWNCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATVNGAAKEPPPPY

--------------------------------------------------------------
>51880_51880_4_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000520016_LAPTM4B_chr8_98827556_ENST00000521545_length(transcript)=1429nt_BP=959nt
GAACTCTGAAAAGGCGGGGCAGCGGGCCTGCAGCTCCTGGAGTTCAGGGAGACCCGGAAATCTCACCCTGCCCTCTTCTTGTGTTGTGTT
TGTCACAGCCTTGCCCCTCTTGCTCGCCTTGAAAATGGAAAAGATGCTCGCAGGCTGCTTTCTGCTGATCCTCGGACAGATCGTCCTCCT
CCCTGCCGAGGCCAGGGAGCGGTCACGTGGGAGGTCCATCTCTAGGGGCAGACACGCTCGGACCCACCCGCAGACGGCCCTTCTGGAGAG
TTCCTGTGAGAACAAGCGGGCAGACCTGGTTTTCATCATTGACAGCTCTCGCAGTGTCAACACCCATGACTATGCAAAGGTCAAGGAGTT
CATCGTGGACATCTTGCAATTCTTGGACATTGGTCCTGATGTCACCCGAGTGGGCCTGCTCCAATATGGCAGCACTGTCAAGAATGAGTT
CTCCCTCAAGACCTTCAAGAGGAAGTCCGAGGTGGAGCGTGCTGTCAAGAGGATGCGGCATCTGTCCACGGGCACCATGACTGGGCTGGC
CATCCAGTATGCCCTGAACATCGCATTCTCAGAAGCAGAGGGGGCCCGGCCCCTGAGGGAGAATGTGCCACGGGTCATAATGATCGTGAC
AGATGGGAGACCTCAGGACTCCGTGGCCGAGGTGGCTGCTAAGGCACGGGACACGGGCATCCTAATCTTTGCCATTGGTGTGGGCCAGGT
AGACTTCAACACCTTGAAGTCCATTGGGAGTGAGCCCCATGAGGACCATGTCTTCCTTGTGGCCAATTTCAGCCAGATTGAGACGCTGAC
CTCCGTGTTCCAGAAGAAGTTGTGCACGGCCCATATGTGCAGCACCCTGGAGCATAACTGTGCCCACTTCTGCATCAACATCCCTGGCTC
ATACGTCTGCAGGTGCAAACAAGGCTACATTCTCAACTCGGATCAGACGACTTGCAGAAACATGTGCATTGCCATTGCGATTTCTCTTCT
CATGATCCTGATATGTGCTATGGCTACTTACGGAGCGTACAAGCAACGCGCAGCCTGGATCATCCCATTCTTCTGTTACCAGATCTTTGA
CTTTGCCCTGAACATGTTGGTTGCAATCACTGTGCTTATTTATCCAAACTCCATTCAGGAATACATACGGCAACTGCCTCCTAATTTTCC
CTACAGAGATGATGTCATGTCAGTGAATCCTACCTGTTTGGTCCTTATTATTCTTCTGTTTATTAGCATTATCTTGACTTTTAAGGGTTA
CTTGATTAGCTGTGTTTGGAACTGCTACCGATACATCAATGGTAGGAACTCCTCTGATGTCCTGGTTTATGTTACCAGCAATGACACTAC

>51880_51880_4_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000520016_LAPTM4B_chr8_98827556_ENST00000521545_length(amino acids)=454AA_BP=298
MPSSCVVFVTALPLLLALKMEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTH
DYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENV
PRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAH
FCINIPGSYVCRCKQGYILNSDQTTCRNMCIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYI
RQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVWNCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATVNGAAKEPPPPY

--------------------------------------------------------------
>51880_51880_5_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000521689_LAPTM4B_chr8_98827556_ENST00000445593_length(transcript)=3318nt_BP=1309nt
GATGCCCGCCTGGGCTCAGGCACGGACGGAGTGGAGCCAGGTGGCAGCAGGCAGGGCGCGCCGCCAGAGTGCCCAGCTCCCGGGGCTGCC
CACAGGGTGGGGCCGCCCTCGCCGCCGCTCCCTCTCCGCGCCTTCCCCATCCCCAAAGAGGACACCCCTCCTTCCGCCCGGCCCGCTCCC
CACCCCCGCCGCGGCACCGCCTCCCCAGCCGCCCGCCCTTGCCCAGCGCCTCCCAGGCAGCCAGCGAGCGAAGGGAGCGCTCTGGGATGG
GACTTGGAGCAAGCGGCGGCGGCGGAGACAGAGGCAGAGGCAGAAGCTGGGGCTCCGTCCTCGCCTCCCACGAGCGATCCCCGAGGAGAG
CCGCGGCCCTCGGCGAGGCGAAGAGGCCGACGAGGAAGACCCGGGTGGCTGCGCCCCTGCCTCGCTTCCCAGGCGCCGGCGGCTGCAGCC
TTGCCCCTCTTGCTCGCCTTGAAAATGGAAAAGATGCTCGCAGGCTGCTTTCTGCTGATCCTCGGACAGATCGTCCTCCTCCCTGCCGAG
GCCAGGGAGCGGTCACGTGGGAGGTCCATCTCTAGGGGCAGACACGCTCGGACCCACCCGCAGACGGCCCTTCTGGAGAGTTCCTGTGAG
AACAAGCGGGCAGACCTGGTTTTCATCATTGACAGCTCTCGCAGTGTCAACACCCATGACTATGCAAAGGTCAAGGAGTTCATCGTGGAC
ATCTTGCAATTCTTGGACATTGGTCCTGATGTCACCCGAGTGGGCCTGCTCCAATATGGCAGCACTGTCAAGAATGAGTTCTCCCTCAAG
ACCTTCAAGAGGAAGTCCGAGGTGGAGCGTGCTGTCAAGAGGATGCGGCATCTGTCCACGGGCACCATGACTGGGCTGGCCATCCAGTAT
GCCCTGAACATCGCATTCTCAGAAGCAGAGGGGGCCCGGCCCCTGAGGGAGAATGTGCCACGGGTCATAATGATCGTGACAGATGGGAGA
CCTCAGGACTCCGTGGCCGAGGTGGCTGCTAAGGCACGGGACACGGGCATCCTAATCTTTGCCATTGGTGTGGGCCAGGTAGACTTCAAC
ACCTTGAAGTCCATTGGGAGTGAGCCCCATGAGGACCATGTCTTCCTTGTGGCCAATTTCAGCCAGATTGAGACGCTGACCTCCGTGTTC
CAGAAGAAGTTGTGCACGGCCCATATGTGCAGCACCCTGGAGCATAACTGTGCCCACTTCTGCATCAACATCCCTGGCTCATACGTCTGC
AGGTGCAAACAAGGCTACATTCTCAACTCGGATCAGACGACTTGCAGAAACATGTGCATTGCCATTGCGATTTCTCTTCTCATGATCCTG
ATATGTGCTATGGCTACTTACGGAGCGTACAAGCAACGCGCAGCCTGGATCATCCCATTCTTCTGTTACCAGATCTTTGACTTTGCCCTG
AACATGTTGGTTGCAATCACTGTGCTTATTTATCCAAACTCCATTCAGGAATACATACGGCAACTGCCTCCTAATTTTCCCTACAGAGAT
GATGTCATGTCAGTGAATCCTACCTGTTTGGTCCTTATTATTCTTCTGTTTATTAGCATTATCTTGACTTTTAAGGGTTACTTGATTAGC
TGTGTTTGGAACTGCTACCGATACATCAATGGTAGGAACTCCTCTGATGTCCTGGTTTATGTTACCAGCAATGACACTACGGTGCTGCTA
CCCCCGTATGATGATGCCACTGTGAATGGTGCTGCCAAGGAGCCACCGCCACCTTACGTGTCTGCCTAAGCCTTCAAGTGGGCGGAGCTG
AGGGCAGCAGCTTGACTTTGCAGACATCTGAGCAATAGTTCTGTTATTTCACTTTTGCCATGAGCCTCTCTGAGCTTGTTTGTTGCTGAA
ATGCTACTTTTTAAAATTTAGATGTTAGATTGAAAACTGTAGTTTTCAACATATGCTTTGCTGGAACACTGTGATAGATTAACTGTAGAA
TTCTTCCTGTACGATTGGGGATATAATGGGCTTCACTAACCTTCCCTAGGCATTGAAACTTCCCCCAAATCTGATGGACCTAGAAGTCTG
CTTTTGTACCTGCTGGGCCCCAAAGTTGGGCATTTTTCTCTCTGTTCCCTCTCTTTTGAAAATGTAAAATAAAACCAAAAATAGACAACT
TTTTCTTCAGCCATTCCAGCATAGAGAACAAAACCTTATGGAAACAGGAATGTCAATTGTGTAATCATTGTTCTAATTAGGTAAATAGAA
GTCCTTATGTATGTGTTACAAGAATTTCCCCCACAACATCCTTTATGACTGAAGTTCAATGACAGTTTGTGTTTGGTGGTAAAGGATTTT
CTCCATGGCCTGAATTAAGACCATTAGAAAGCACCAGGCCGTGGGAGCAGTGACCATCTGCTGACTGTTCTTGTGGATCTTGTGTCCAGG
GACATGGGGTGACATGCCTCGTATGTGTTAGAGGGTGGAATGGATGTGTTTGGCGCTGCATGGGATCTGGTGCCCCTCTTCTCCTGGATT
CACATCCCCACCCAGGGCCCGCTTTTACTAAGTGTTCTGCCCTAGATTGGTTCAAGGAGGTCATCCAACTGACTTTATCAAGTGGAATTG
GGATATATTTGATATACTTCTGCCTAACAACATGGAAAAGGGTTTTCTTTTCCCTGCAAGCTACATCCTACTGCTTTGAACTTCCAAGTA
TGTCTAGTCACCTTTTAAAATGTAAACATTTTCAGAAAAATGAGGATTGCCTTCCTTGTATGCGCTTTTTACCTTGACTACCTGAATTGC
AAGGGATTTTTATATATTCATATGTTACAAAGTCAGCAACTCTCCTGTTGGTTCATTATTGAATGTGCTGTAAATTAAGTTGTTTGCAAT
TAAAACAAGGTTTGCCCACATCCAAGATGACCTTGTGATTTTGTGCTGATTGTGTCTGAGGACCTTTCCCTCCACATATGGTCTGGCAGA
TGCACCCAGTTCAGCCTAAGGAGTAGGCTTTTTTTTGGGGGGGGGAGGTCGGGTGGGGGGGATTTTTAATCTTTTAATTTTCAAGATGGT
TAAAATATTGAAATGTTTAAGTGGATAACTATATTATTCATAAAATGACTGAGTGAAAACTAATACACTATGAGATGAAAAGTACTTGTC
AGGGATTTTCAAGCTTTTGCTCAAGTAATTACTATGAAATAACAATTTCTAGAAATGAAGAACAATCCGTGGAGAATAAATTACCATTGG

>51880_51880_5_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000521689_LAPTM4B_chr8_98827556_ENST00000445593_length(amino acids)=589AA_BP=434
MGSGTDGVEPGGSRQGAPPECPAPGAAHRVGPPSPPLPLRAFPIPKEDTPPSARPAPHPRRGTASPAARPCPAPPRQPASEGSALGWDLE
QAAAAETEAEAEAGAPSSPPTSDPRGEPRPSARRRGRRGRPGWLRPCLASQAPAAAALPLLLALKMEKMLAGCFLLILGQIVLLPAEARE
RSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFK
RKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLK
SIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRNMCIAIAISLLMILICA
MATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVW

--------------------------------------------------------------
>51880_51880_6_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000521689_LAPTM4B_chr8_98827556_ENST00000521545_length(transcript)=1779nt_BP=1309nt
GATGCCCGCCTGGGCTCAGGCACGGACGGAGTGGAGCCAGGTGGCAGCAGGCAGGGCGCGCCGCCAGAGTGCCCAGCTCCCGGGGCTGCC
CACAGGGTGGGGCCGCCCTCGCCGCCGCTCCCTCTCCGCGCCTTCCCCATCCCCAAAGAGGACACCCCTCCTTCCGCCCGGCCCGCTCCC
CACCCCCGCCGCGGCACCGCCTCCCCAGCCGCCCGCCCTTGCCCAGCGCCTCCCAGGCAGCCAGCGAGCGAAGGGAGCGCTCTGGGATGG
GACTTGGAGCAAGCGGCGGCGGCGGAGACAGAGGCAGAGGCAGAAGCTGGGGCTCCGTCCTCGCCTCCCACGAGCGATCCCCGAGGAGAG
CCGCGGCCCTCGGCGAGGCGAAGAGGCCGACGAGGAAGACCCGGGTGGCTGCGCCCCTGCCTCGCTTCCCAGGCGCCGGCGGCTGCAGCC
TTGCCCCTCTTGCTCGCCTTGAAAATGGAAAAGATGCTCGCAGGCTGCTTTCTGCTGATCCTCGGACAGATCGTCCTCCTCCCTGCCGAG
GCCAGGGAGCGGTCACGTGGGAGGTCCATCTCTAGGGGCAGACACGCTCGGACCCACCCGCAGACGGCCCTTCTGGAGAGTTCCTGTGAG
AACAAGCGGGCAGACCTGGTTTTCATCATTGACAGCTCTCGCAGTGTCAACACCCATGACTATGCAAAGGTCAAGGAGTTCATCGTGGAC
ATCTTGCAATTCTTGGACATTGGTCCTGATGTCACCCGAGTGGGCCTGCTCCAATATGGCAGCACTGTCAAGAATGAGTTCTCCCTCAAG
ACCTTCAAGAGGAAGTCCGAGGTGGAGCGTGCTGTCAAGAGGATGCGGCATCTGTCCACGGGCACCATGACTGGGCTGGCCATCCAGTAT
GCCCTGAACATCGCATTCTCAGAAGCAGAGGGGGCCCGGCCCCTGAGGGAGAATGTGCCACGGGTCATAATGATCGTGACAGATGGGAGA
CCTCAGGACTCCGTGGCCGAGGTGGCTGCTAAGGCACGGGACACGGGCATCCTAATCTTTGCCATTGGTGTGGGCCAGGTAGACTTCAAC
ACCTTGAAGTCCATTGGGAGTGAGCCCCATGAGGACCATGTCTTCCTTGTGGCCAATTTCAGCCAGATTGAGACGCTGACCTCCGTGTTC
CAGAAGAAGTTGTGCACGGCCCATATGTGCAGCACCCTGGAGCATAACTGTGCCCACTTCTGCATCAACATCCCTGGCTCATACGTCTGC
AGGTGCAAACAAGGCTACATTCTCAACTCGGATCAGACGACTTGCAGAAACATGTGCATTGCCATTGCGATTTCTCTTCTCATGATCCTG
ATATGTGCTATGGCTACTTACGGAGCGTACAAGCAACGCGCAGCCTGGATCATCCCATTCTTCTGTTACCAGATCTTTGACTTTGCCCTG
AACATGTTGGTTGCAATCACTGTGCTTATTTATCCAAACTCCATTCAGGAATACATACGGCAACTGCCTCCTAATTTTCCCTACAGAGAT
GATGTCATGTCAGTGAATCCTACCTGTTTGGTCCTTATTATTCTTCTGTTTATTAGCATTATCTTGACTTTTAAGGGTTACTTGATTAGC
TGTGTTTGGAACTGCTACCGATACATCAATGGTAGGAACTCCTCTGATGTCCTGGTTTATGTTACCAGCAATGACACTACGGTGCTGCTA

>51880_51880_6_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000521689_LAPTM4B_chr8_98827556_ENST00000521545_length(amino acids)=589AA_BP=434
MGSGTDGVEPGGSRQGAPPECPAPGAAHRVGPPSPPLPLRAFPIPKEDTPPSARPAPHPRRGTASPAARPCPAPPRQPASEGSALGWDLE
QAAAAETEAEAEAGAPSSPPTSDPRGEPRPSARRRGRRGRPGWLRPCLASQAPAAAALPLLLALKMEKMLAGCFLLILGQIVLLPAEARE
RSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFK
RKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLK
SIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRNMCIAIAISLLMILICA
MATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVW

--------------------------------------------------------------
>51880_51880_7_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000524308_LAPTM4B_chr8_98827556_ENST00000445593_length(transcript)=3047nt_BP=1038nt
ACTTGGAGCAAGCGGCGGCGGCGGAGACAGAGGCAGAGGCAGAAGCTGGGGCTCCGTCCTCGCCTCCCACGAGCGATCCCCGAGGAGAGC
CGCGGCCCTCGGCGAGGCGAAGAGGCCGACGAGGAAGACCCGGGTGGCTGCGCCCCTGCCTCGCTTCCCAGGCGCCGGCGGCTGCAGCCT
TGCCCCTCTTGCTCGCCTTGAAAATGGAAAAGATGCTCGCAGGCTGCTTTCTGCTGATCCTCGGACAGATCGTCCTCCTCCCTGCCGAGG
CCAGGGAGCGGTCACGTGGGAGGTCCATCTCTAGGGGCAGACACGCTCGGACCCACCCGCAGACGGCCCTTCTGGAGAGTTCCTGTGAGA
ACAAGCGGGCAGACCTGGTTTTCATCATTGACAGCTCTCGCAGTGTCAACACCCATGACTATGCAAAGGTCAAGGAGTTCATCGTGGACA
TCTTGCAATTCTTGGACATTGGTCCTGATGTCACCCGAGTGGGCCTGCTCCAATATGGCAGCACTGTCAAGAATGAGTTCTCCCTCAAGA
CCTTCAAGAGGAAGTCCGAGGTGGAGCGTGCTGTCAAGAGGATGCGGCATCTGTCCACGGGCACCATGACTGGGCTGGCCATCCAGTATG
CCCTGAACATCGCATTCTCAGAAGCAGAGGGGGCCCGGCCCCTGAGGGAGAATGTGCCACGGGTCATAATGATCGTGACAGATGGGAGAC
CTCAGGACTCCGTGGCCGAGGTGGCTGCTAAGGCACGGGACACGGGCATCCTAATCTTTGCCATTGGTGTGGGCCAGGTAGACTTCAACA
CCTTGAAGTCCATTGGGAGTGAGCCCCATGAGGACCATGTCTTCCTTGTGGCCAATTTCAGCCAGATTGAGACGCTGACCTCCGTGTTCC
AGAAGAAGTTGTGCACGGCCCATATGTGCAGCACCCTGGAGCATAACTGTGCCCACTTCTGCATCAACATCCCTGGCTCATACGTCTGCA
GGTGCAAACAAGGCTACATTCTCAACTCGGATCAGACGACTTGCAGAAACATGTGCATTGCCATTGCGATTTCTCTTCTCATGATCCTGA
TATGTGCTATGGCTACTTACGGAGCGTACAAGCAACGCGCAGCCTGGATCATCCCATTCTTCTGTTACCAGATCTTTGACTTTGCCCTGA
ACATGTTGGTTGCAATCACTGTGCTTATTTATCCAAACTCCATTCAGGAATACATACGGCAACTGCCTCCTAATTTTCCCTACAGAGATG
ATGTCATGTCAGTGAATCCTACCTGTTTGGTCCTTATTATTCTTCTGTTTATTAGCATTATCTTGACTTTTAAGGGTTACTTGATTAGCT
GTGTTTGGAACTGCTACCGATACATCAATGGTAGGAACTCCTCTGATGTCCTGGTTTATGTTACCAGCAATGACACTACGGTGCTGCTAC
CCCCGTATGATGATGCCACTGTGAATGGTGCTGCCAAGGAGCCACCGCCACCTTACGTGTCTGCCTAAGCCTTCAAGTGGGCGGAGCTGA
GGGCAGCAGCTTGACTTTGCAGACATCTGAGCAATAGTTCTGTTATTTCACTTTTGCCATGAGCCTCTCTGAGCTTGTTTGTTGCTGAAA
TGCTACTTTTTAAAATTTAGATGTTAGATTGAAAACTGTAGTTTTCAACATATGCTTTGCTGGAACACTGTGATAGATTAACTGTAGAAT
TCTTCCTGTACGATTGGGGATATAATGGGCTTCACTAACCTTCCCTAGGCATTGAAACTTCCCCCAAATCTGATGGACCTAGAAGTCTGC
TTTTGTACCTGCTGGGCCCCAAAGTTGGGCATTTTTCTCTCTGTTCCCTCTCTTTTGAAAATGTAAAATAAAACCAAAAATAGACAACTT
TTTCTTCAGCCATTCCAGCATAGAGAACAAAACCTTATGGAAACAGGAATGTCAATTGTGTAATCATTGTTCTAATTAGGTAAATAGAAG
TCCTTATGTATGTGTTACAAGAATTTCCCCCACAACATCCTTTATGACTGAAGTTCAATGACAGTTTGTGTTTGGTGGTAAAGGATTTTC
TCCATGGCCTGAATTAAGACCATTAGAAAGCACCAGGCCGTGGGAGCAGTGACCATCTGCTGACTGTTCTTGTGGATCTTGTGTCCAGGG
ACATGGGGTGACATGCCTCGTATGTGTTAGAGGGTGGAATGGATGTGTTTGGCGCTGCATGGGATCTGGTGCCCCTCTTCTCCTGGATTC
ACATCCCCACCCAGGGCCCGCTTTTACTAAGTGTTCTGCCCTAGATTGGTTCAAGGAGGTCATCCAACTGACTTTATCAAGTGGAATTGG
GATATATTTGATATACTTCTGCCTAACAACATGGAAAAGGGTTTTCTTTTCCCTGCAAGCTACATCCTACTGCTTTGAACTTCCAAGTAT
GTCTAGTCACCTTTTAAAATGTAAACATTTTCAGAAAAATGAGGATTGCCTTCCTTGTATGCGCTTTTTACCTTGACTACCTGAATTGCA
AGGGATTTTTATATATTCATATGTTACAAAGTCAGCAACTCTCCTGTTGGTTCATTATTGAATGTGCTGTAAATTAAGTTGTTTGCAATT
AAAACAAGGTTTGCCCACATCCAAGATGACCTTGTGATTTTGTGCTGATTGTGTCTGAGGACCTTTCCCTCCACATATGGTCTGGCAGAT
GCACCCAGTTCAGCCTAAGGAGTAGGCTTTTTTTTGGGGGGGGGAGGTCGGGTGGGGGGGATTTTTAATCTTTTAATTTTCAAGATGGTT
AAAATATTGAAATGTTTAAGTGGATAACTATATTATTCATAAAATGACTGAGTGAAAACTAATACACTATGAGATGAAAAGTACTTGTCA
GGGATTTTCAAGCTTTTGCTCAAGTAATTACTATGAAATAACAATTTCTAGAAATGAAGAACAATCCGTGGAGAATAAATTACCATTGGT

>51880_51880_7_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000524308_LAPTM4B_chr8_98827556_ENST00000445593_length(amino acids)=501AA_BP=346
LEQAAAAETEAEAEAGAPSSPPTSDPRGEPRPSARRRGRRGRPGWLRPCLASQAPAAAALPLLLALKMEKMLAGCFLLILGQIVLLPAEA
RERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKT
FKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNT
LKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRNMCIAIAISLLMILI
CAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISC

--------------------------------------------------------------
>51880_51880_8_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000524308_LAPTM4B_chr8_98827556_ENST00000521545_length(transcript)=1508nt_BP=1038nt
ACTTGGAGCAAGCGGCGGCGGCGGAGACAGAGGCAGAGGCAGAAGCTGGGGCTCCGTCCTCGCCTCCCACGAGCGATCCCCGAGGAGAGC
CGCGGCCCTCGGCGAGGCGAAGAGGCCGACGAGGAAGACCCGGGTGGCTGCGCCCCTGCCTCGCTTCCCAGGCGCCGGCGGCTGCAGCCT
TGCCCCTCTTGCTCGCCTTGAAAATGGAAAAGATGCTCGCAGGCTGCTTTCTGCTGATCCTCGGACAGATCGTCCTCCTCCCTGCCGAGG
CCAGGGAGCGGTCACGTGGGAGGTCCATCTCTAGGGGCAGACACGCTCGGACCCACCCGCAGACGGCCCTTCTGGAGAGTTCCTGTGAGA
ACAAGCGGGCAGACCTGGTTTTCATCATTGACAGCTCTCGCAGTGTCAACACCCATGACTATGCAAAGGTCAAGGAGTTCATCGTGGACA
TCTTGCAATTCTTGGACATTGGTCCTGATGTCACCCGAGTGGGCCTGCTCCAATATGGCAGCACTGTCAAGAATGAGTTCTCCCTCAAGA
CCTTCAAGAGGAAGTCCGAGGTGGAGCGTGCTGTCAAGAGGATGCGGCATCTGTCCACGGGCACCATGACTGGGCTGGCCATCCAGTATG
CCCTGAACATCGCATTCTCAGAAGCAGAGGGGGCCCGGCCCCTGAGGGAGAATGTGCCACGGGTCATAATGATCGTGACAGATGGGAGAC
CTCAGGACTCCGTGGCCGAGGTGGCTGCTAAGGCACGGGACACGGGCATCCTAATCTTTGCCATTGGTGTGGGCCAGGTAGACTTCAACA
CCTTGAAGTCCATTGGGAGTGAGCCCCATGAGGACCATGTCTTCCTTGTGGCCAATTTCAGCCAGATTGAGACGCTGACCTCCGTGTTCC
AGAAGAAGTTGTGCACGGCCCATATGTGCAGCACCCTGGAGCATAACTGTGCCCACTTCTGCATCAACATCCCTGGCTCATACGTCTGCA
GGTGCAAACAAGGCTACATTCTCAACTCGGATCAGACGACTTGCAGAAACATGTGCATTGCCATTGCGATTTCTCTTCTCATGATCCTGA
TATGTGCTATGGCTACTTACGGAGCGTACAAGCAACGCGCAGCCTGGATCATCCCATTCTTCTGTTACCAGATCTTTGACTTTGCCCTGA
ACATGTTGGTTGCAATCACTGTGCTTATTTATCCAAACTCCATTCAGGAATACATACGGCAACTGCCTCCTAATTTTCCCTACAGAGATG
ATGTCATGTCAGTGAATCCTACCTGTTTGGTCCTTATTATTCTTCTGTTTATTAGCATTATCTTGACTTTTAAGGGTTACTTGATTAGCT
GTGTTTGGAACTGCTACCGATACATCAATGGTAGGAACTCCTCTGATGTCCTGGTTTATGTTACCAGCAATGACACTACGGTGCTGCTAC

>51880_51880_8_MATN2-LAPTM4B_MATN2_chr8_98954127_ENST00000524308_LAPTM4B_chr8_98827556_ENST00000521545_length(amino acids)=502AA_BP=346
LEQAAAAETEAEAEAGAPSSPPTSDPRGEPRPSARRRGRRGRPGWLRPCLASQAPAAAALPLLLALKMEKMLAGCFLLILGQIVLLPAEA
RERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKT
FKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNT
LKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRNMCIAIAISLLMILI
CAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MATN2-LAPTM4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MATN2-LAPTM4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MATN2-LAPTM4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource