FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MATR3-ALB (FusionGDB2 ID:51887)

Fusion Gene Summary for MATR3-ALB

check button Fusion gene summary
Fusion gene informationFusion gene name: MATR3-ALB
Fusion gene ID: 51887
HgeneTgene
Gene symbol

MATR3

ALB

Gene ID

9782

213

Gene namematrin 3albumin
SynonymsALS21|MPD2|VCPDMHSA|PRO0883|PRO0903|PRO1341
Cytomap

5q31.2

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionmatrin-3vocal cord and pharyngeal weakness with distal myopathyserum albumin
Modification date2020031520200329
UniProtAcc

P43243

P02768

Ensembl transtripts involved in fusion geneENST00000361059, ENST00000394800, 
ENST00000394805, ENST00000502499, 
ENST00000502929, ENST00000503811, 
ENST00000504203, ENST00000507197, 
ENST00000509990, ENST00000510056, 
ENST00000295897, ENST00000401494, 
ENST00000415165, ENST00000503124, 
ENST00000505649, ENST00000509063, 
Fusion gene scores* DoF score39 X 15 X 12=702049 X 62 X 5=15190
# samples 4164
** MAII scorelog2(41/7020*10)=-4.09777521568648
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(64/15190*10)=-4.56890615450208
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MATR3 [Title/Abstract] AND ALB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMATR3(138631171)-ALB(74287034), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMATR3

GO:0002218

activation of innate immune response

28712728

HgeneMATR3

GO:0010608

posttranscriptional regulation of gene expression

21771347

TgeneALB

GO:0009267

cellular response to starvation

16245148

TgeneALB

GO:0043066

negative regulation of apoptotic process

16153637

TgeneALB

GO:0051659

maintenance of mitochondrion location

16153637


check buttonFusion gene breakpoints across MATR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ALB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAF116688MATR3chr5

138631171

-ALBchr4

74287034

+


Top

Fusion Gene ORF analysis for MATR3-ALB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000361059ENST00000295897MATR3chr5

138631171

-ALBchr4

74287034

+
intron-3UTRENST00000394800ENST00000295897MATR3chr5

138631171

-ALBchr4

74287034

+
intron-3UTRENST00000394805ENST00000295897MATR3chr5

138631171

-ALBchr4

74287034

+
intron-3UTRENST00000502499ENST00000295897MATR3chr5

138631171

-ALBchr4

74287034

+
intron-3UTRENST00000502929ENST00000295897MATR3chr5

138631171

-ALBchr4

74287034

+
intron-3UTRENST00000503811ENST00000295897MATR3chr5

138631171

-ALBchr4

74287034

+
intron-3UTRENST00000504203ENST00000295897MATR3chr5

138631171

-ALBchr4

74287034

+
intron-3UTRENST00000507197ENST00000295897MATR3chr5

138631171

-ALBchr4

74287034

+
intron-3UTRENST00000509990ENST00000295897MATR3chr5

138631171

-ALBchr4

74287034

+
intron-3UTRENST00000510056ENST00000295897MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000361059ENST00000401494MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000361059ENST00000415165MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000361059ENST00000503124MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000361059ENST00000505649MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000361059ENST00000509063MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000394800ENST00000401494MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000394800ENST00000415165MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000394800ENST00000503124MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000394800ENST00000505649MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000394800ENST00000509063MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000394805ENST00000401494MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000394805ENST00000415165MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000394805ENST00000503124MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000394805ENST00000505649MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000394805ENST00000509063MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000502499ENST00000401494MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000502499ENST00000415165MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000502499ENST00000503124MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000502499ENST00000505649MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000502499ENST00000509063MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000502929ENST00000401494MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000502929ENST00000415165MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000502929ENST00000503124MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000502929ENST00000505649MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000502929ENST00000509063MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000503811ENST00000401494MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000503811ENST00000415165MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000503811ENST00000503124MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000503811ENST00000505649MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000503811ENST00000509063MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000504203ENST00000401494MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000504203ENST00000415165MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000504203ENST00000503124MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000504203ENST00000505649MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000504203ENST00000509063MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000507197ENST00000401494MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000507197ENST00000415165MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000507197ENST00000503124MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000507197ENST00000505649MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000507197ENST00000509063MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000509990ENST00000401494MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000509990ENST00000415165MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000509990ENST00000503124MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000509990ENST00000505649MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000509990ENST00000509063MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000510056ENST00000401494MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000510056ENST00000415165MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000510056ENST00000503124MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000510056ENST00000505649MATR3chr5

138631171

-ALBchr4

74287034

+
intron-intronENST00000510056ENST00000509063MATR3chr5

138631171

-ALBchr4

74287034

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MATR3-ALB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MATR3-ALB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:138631171/:74287034)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MATR3

P43243

ALB

P02768

FUNCTION: May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728}.FUNCTION: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017). {ECO:0000250|UniProtKB:P02769, ECO:0000269|PubMed:19021548, ECO:0000269|PubMed:6234017, ECO:0000305|PubMed:1630489}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for MATR3-ALB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MATR3-ALB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MATR3-ALB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MATR3-ALB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource