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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MATR3-GNAI3 (FusionGDB2 ID:51898) |
Fusion Gene Summary for MATR3-GNAI3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MATR3-GNAI3 | Fusion gene ID: 51898 | Hgene | Tgene | Gene symbol | MATR3 | GNAI3 | Gene ID | 9782 | 2773 |
| Gene name | matrin 3 | G protein subunit alpha i3 | |
| Synonyms | ALS21|MPD2|VCPDM | 87U6|ARCND1 | |
| Cytomap | 5q31.2 | 1p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | matrin-3vocal cord and pharyngeal weakness with distal myopathy | guanine nucleotide-binding protein G(i) subunit alphag(i) alpha-3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3guanine nucleotide-binding protein G(k) subunit alpha | |
| Modification date | 20200315 | 20200322 | |
| UniProtAcc | P43243 | P08754 | |
| Ensembl transtripts involved in fusion gene | ENST00000394805, ENST00000502499, ENST00000503811, ENST00000510056, ENST00000361059, ENST00000394800, ENST00000502929, ENST00000504203, ENST00000507197, ENST00000509990, | ENST00000369851, | |
| Fusion gene scores | * DoF score | 39 X 15 X 12=7020 | 33 X 8 X 14=3696 |
| # samples | 41 | 35 | |
| ** MAII score | log2(41/7020*10)=-4.09777521568648 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(35/3696*10)=-3.40053792958373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MATR3 [Title/Abstract] AND GNAI3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MATR3(138629494)-GNAI3(110116358), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MATR3 | GO:0002218 | activation of innate immune response | 28712728 |
| Hgene | MATR3 | GO:0010608 | posttranscriptional regulation of gene expression | 21771347 |
| Tgene | GNAI3 | GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 19478087 |
| Tgene | GNAI3 | GO:0007212 | dopamine receptor signaling pathway | 19478087 |
| Tgene | GNAI3 | GO:0046039 | GTP metabolic process | 19478087 |
| Tgene | GNAI3 | GO:0051301 | cell division | 17635935 |
| Fusion gene breakpoints across MATR3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across GNAI3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-CH-5746 | MATR3 | chr5 | 138629494 | + | GNAI3 | chr1 | 110116358 | + |
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Fusion Gene ORF analysis for MATR3-GNAI3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000394805 | ENST00000369851 | MATR3 | chr5 | 138629494 | + | GNAI3 | chr1 | 110116358 | + |
| 5UTR-3CDS | ENST00000502499 | ENST00000369851 | MATR3 | chr5 | 138629494 | + | GNAI3 | chr1 | 110116358 | + |
| 5UTR-3CDS | ENST00000503811 | ENST00000369851 | MATR3 | chr5 | 138629494 | + | GNAI3 | chr1 | 110116358 | + |
| 5UTR-3CDS | ENST00000510056 | ENST00000369851 | MATR3 | chr5 | 138629494 | + | GNAI3 | chr1 | 110116358 | + |
| intron-3CDS | ENST00000361059 | ENST00000369851 | MATR3 | chr5 | 138629494 | + | GNAI3 | chr1 | 110116358 | + |
| intron-3CDS | ENST00000394800 | ENST00000369851 | MATR3 | chr5 | 138629494 | + | GNAI3 | chr1 | 110116358 | + |
| intron-3CDS | ENST00000502929 | ENST00000369851 | MATR3 | chr5 | 138629494 | + | GNAI3 | chr1 | 110116358 | + |
| intron-3CDS | ENST00000504203 | ENST00000369851 | MATR3 | chr5 | 138629494 | + | GNAI3 | chr1 | 110116358 | + |
| intron-3CDS | ENST00000507197 | ENST00000369851 | MATR3 | chr5 | 138629494 | + | GNAI3 | chr1 | 110116358 | + |
| intron-3CDS | ENST00000509990 | ENST00000369851 | MATR3 | chr5 | 138629494 | + | GNAI3 | chr1 | 110116358 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for MATR3-GNAI3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MATR3-GNAI3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:138629494/:110116358) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MATR3 | GNAI3 |
| FUNCTION: May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728}. | FUNCTION: Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). {ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:8774883}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MATR3-GNAI3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for MATR3-GNAI3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MATR3-GNAI3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MATR3-GNAI3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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