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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MATR3-MATR3 (FusionGDB2 ID:51904)

Fusion Gene Summary for MATR3-MATR3

check button Fusion gene summary
Fusion gene informationFusion gene name: MATR3-MATR3
Fusion gene ID: 51904
HgeneTgene
Gene symbol

MATR3

MATR3

Gene ID

9782

9782

Gene namematrin 3matrin 3
SynonymsALS21|MPD2|VCPDMALS21|MPD2|VCPDM
Cytomap

5q31.2

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionmatrin-3vocal cord and pharyngeal weakness with distal myopathymatrin-3vocal cord and pharyngeal weakness with distal myopathy
Modification date2020031520200315
UniProtAcc

P43243

P43243

Ensembl transtripts involved in fusion geneENST00000361059, ENST00000394800, 
ENST00000394805, ENST00000502499, 
ENST00000502929, ENST00000503811, 
ENST00000504203, ENST00000509990, 
ENST00000510056, ENST00000507197, 
ENST00000394800, ENST00000394805, 
ENST00000502499, ENST00000502929, 
ENST00000503811, ENST00000504203, 
ENST00000507197, ENST00000510056, 
ENST00000361059, ENST00000509990, 
Fusion gene scores* DoF score39 X 15 X 12=702010 X 10 X 6=600
# samples 4113
** MAII scorelog2(41/7020*10)=-4.09777521568648
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/600*10)=-2.20645087746743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MATR3 [Title/Abstract] AND MATR3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMATR3(138658326)-MATR3(138658491), # samples:3
Anticipated loss of major functional domain due to fusion event.MATR3-MATR3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MATR3-MATR3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMATR3

GO:0002218

activation of innate immune response

28712728

HgeneMATR3

GO:0010608

posttranscriptional regulation of gene expression

21771347

TgeneMATR3

GO:0002218

activation of innate immune response

28712728

TgeneMATR3

GO:0010608

posttranscriptional regulation of gene expression

21771347


check buttonFusion gene breakpoints across MATR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MATR3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA650232MATR3chr5

138658326

+MATR3chr5

138658491

-
ChiTaRS5.0N/AAA654758MATR3chr5

138658326

+MATR3chr5

138658491

-
ChiTaRS5.0N/AAA808866MATR3chr5

138658326

+MATR3chr5

138658491

-
ChiTaRS5.0N/AAJ224166MATR3chr5

138643213

+MATR3chr5

138643367

-


Top

Fusion Gene ORF analysis for MATR3-MATR3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000361059ENST00000394800MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000361059ENST00000394805MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000361059ENST00000394805MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000361059ENST00000502499MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000361059ENST00000502499MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000361059ENST00000502929MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000361059ENST00000503811MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000361059ENST00000503811MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000361059ENST00000504203MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000361059ENST00000507197MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000361059ENST00000507197MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000361059ENST00000510056MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000361059ENST00000510056MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394800ENST00000394800MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394800ENST00000394805MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000394800ENST00000394805MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394800ENST00000502499MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000394800ENST00000502499MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394800ENST00000502929MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394800ENST00000503811MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000394800ENST00000503811MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394800ENST00000504203MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394800ENST00000507197MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000394800ENST00000507197MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394800ENST00000510056MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000394800ENST00000510056MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394805ENST00000394800MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394805ENST00000394805MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000394805ENST00000394805MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394805ENST00000502499MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000394805ENST00000502499MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394805ENST00000502929MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394805ENST00000503811MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000394805ENST00000503811MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394805ENST00000504203MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394805ENST00000507197MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000394805ENST00000507197MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000394805ENST00000510056MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000394805ENST00000510056MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000502499ENST00000394805MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000502499ENST00000502499MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000502499ENST00000503811MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000502499ENST00000507197MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000502499ENST00000510056MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000502929ENST00000394800MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000502929ENST00000394805MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000502929ENST00000394805MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000502929ENST00000502499MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000502929ENST00000502499MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000502929ENST00000502929MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000502929ENST00000503811MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000502929ENST00000503811MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000502929ENST00000504203MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000502929ENST00000507197MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000502929ENST00000507197MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000502929ENST00000510056MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000502929ENST00000510056MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000503811ENST00000394805MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000503811ENST00000502499MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000503811ENST00000503811MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000503811ENST00000507197MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000503811ENST00000510056MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000504203ENST00000394805MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000504203ENST00000502499MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000504203ENST00000503811MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000504203ENST00000507197MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000504203ENST00000510056MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000509990ENST00000394800MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000509990ENST00000394805MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000509990ENST00000394805MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000509990ENST00000502499MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000509990ENST00000502499MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000509990ENST00000502929MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000509990ENST00000503811MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000509990ENST00000503811MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000509990ENST00000504203MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000509990ENST00000507197MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000509990ENST00000507197MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000509990ENST00000510056MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000509990ENST00000510056MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000510056ENST00000394800MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000510056ENST00000394805MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000510056ENST00000394805MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000510056ENST00000502499MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000510056ENST00000502499MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000510056ENST00000502929MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000510056ENST00000503811MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000510056ENST00000503811MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000510056ENST00000504203MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000510056ENST00000507197MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000510056ENST00000507197MATR3chr5

138643213

+MATR3chr5

138643367

-
5CDS-intronENST00000510056ENST00000510056MATR3chr5

138658326

+MATR3chr5

138658491

-
5CDS-intronENST00000510056ENST00000510056MATR3chr5

138643213

+MATR3chr5

138643367

-
Frame-shiftENST00000361059ENST00000361059MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000361059ENST00000394800MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000361059ENST00000502929MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000361059ENST00000504203MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000361059ENST00000509990MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000394800ENST00000361059MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000394800ENST00000394800MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000394800ENST00000502929MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000394800ENST00000504203MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000394800ENST00000509990MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000394805ENST00000361059MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000394805ENST00000394800MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000394805ENST00000502929MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000394805ENST00000504203MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000394805ENST00000509990MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000502499ENST00000361059MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000502499ENST00000394800MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000502499ENST00000502929MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000502499ENST00000504203MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000502499ENST00000509990MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000502929ENST00000361059MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000502929ENST00000394800MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000502929ENST00000502929MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000502929ENST00000504203MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000502929ENST00000509990MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000503811ENST00000361059MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000503811ENST00000394800MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000503811ENST00000502929MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000503811ENST00000504203MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000503811ENST00000509990MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000504203ENST00000361059MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000504203ENST00000394800MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000504203ENST00000502929MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000504203ENST00000504203MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000504203ENST00000509990MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000509990ENST00000361059MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000509990ENST00000394800MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000509990ENST00000502929MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000509990ENST00000504203MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000509990ENST00000509990MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000510056ENST00000361059MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000510056ENST00000394800MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000510056ENST00000502929MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000510056ENST00000504203MATR3chr5

138658326

+MATR3chr5

138658491

-
Frame-shiftENST00000510056ENST00000509990MATR3chr5

138658326

+MATR3chr5

138658491

-
In-frameENST00000361059ENST00000361059MATR3chr5

138643213

+MATR3chr5

138643367

-
In-frameENST00000361059ENST00000509990MATR3chr5

138643213

+MATR3chr5

138643367

-
In-frameENST00000394800ENST00000361059MATR3chr5

138643213

+MATR3chr5

138643367

-
In-frameENST00000394800ENST00000509990MATR3chr5

138643213

+MATR3chr5

138643367

-
In-frameENST00000394805ENST00000361059MATR3chr5

138643213

+MATR3chr5

138643367

-
In-frameENST00000394805ENST00000509990MATR3chr5

138643213

+MATR3chr5

138643367

-
In-frameENST00000502929ENST00000361059MATR3chr5

138643213

+MATR3chr5

138643367

-
In-frameENST00000502929ENST00000509990MATR3chr5

138643213

+MATR3chr5

138643367

-
In-frameENST00000509990ENST00000361059MATR3chr5

138643213

+MATR3chr5

138643367

-
In-frameENST00000509990ENST00000509990MATR3chr5

138643213

+MATR3chr5

138643367

-
In-frameENST00000510056ENST00000361059MATR3chr5

138643213

+MATR3chr5

138643367

-
In-frameENST00000510056ENST00000509990MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-3CDSENST00000502499ENST00000361059MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-3CDSENST00000502499ENST00000509990MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-3CDSENST00000503811ENST00000361059MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-3CDSENST00000503811ENST00000509990MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-3CDSENST00000504203ENST00000361059MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-3CDSENST00000504203ENST00000509990MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-3CDSENST00000507197ENST00000361059MATR3chr5

138658326

+MATR3chr5

138658491

-
intron-3CDSENST00000507197ENST00000361059MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-3CDSENST00000507197ENST00000394800MATR3chr5

138658326

+MATR3chr5

138658491

-
intron-3CDSENST00000507197ENST00000502929MATR3chr5

138658326

+MATR3chr5

138658491

-
intron-3CDSENST00000507197ENST00000504203MATR3chr5

138658326

+MATR3chr5

138658491

-
intron-3CDSENST00000507197ENST00000509990MATR3chr5

138658326

+MATR3chr5

138658491

-
intron-3CDSENST00000507197ENST00000509990MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000502499ENST00000394800MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000502499ENST00000394805MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000502499ENST00000502499MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000502499ENST00000502929MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000502499ENST00000503811MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000502499ENST00000504203MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000502499ENST00000507197MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000502499ENST00000510056MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000503811ENST00000394800MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000503811ENST00000394805MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000503811ENST00000502499MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000503811ENST00000502929MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000503811ENST00000503811MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000503811ENST00000504203MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000503811ENST00000507197MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000503811ENST00000510056MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000504203ENST00000394800MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000504203ENST00000394805MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000504203ENST00000502499MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000504203ENST00000502929MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000504203ENST00000503811MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000504203ENST00000504203MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000504203ENST00000507197MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000504203ENST00000510056MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000507197ENST00000394800MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000507197ENST00000394805MATR3chr5

138658326

+MATR3chr5

138658491

-
intron-intronENST00000507197ENST00000394805MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000507197ENST00000502499MATR3chr5

138658326

+MATR3chr5

138658491

-
intron-intronENST00000507197ENST00000502499MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000507197ENST00000502929MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000507197ENST00000503811MATR3chr5

138658326

+MATR3chr5

138658491

-
intron-intronENST00000507197ENST00000503811MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000507197ENST00000504203MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000507197ENST00000507197MATR3chr5

138658326

+MATR3chr5

138658491

-
intron-intronENST00000507197ENST00000507197MATR3chr5

138643213

+MATR3chr5

138643367

-
intron-intronENST00000507197ENST00000510056MATR3chr5

138658326

+MATR3chr5

138658491

-
intron-intronENST00000507197ENST00000510056MATR3chr5

138643213

+MATR3chr5

138643367

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MATR3-MATR3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MATR3-MATR3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:138658326/chr5:138658491)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MATR3

P43243

MATR3

P43243

FUNCTION: May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728}.FUNCTION: May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMATR3chr5:138643213chr5:138643367ENST00000361059018398_4730848.0DomainRRM 1
TgeneMATR3chr5:138643213chr5:138643367ENST00000361059018496_5710848.0DomainRRM 2
TgeneMATR3chr5:138643213chr5:138643367ENST00000394805015398_4730848.0DomainRRM 1
TgeneMATR3chr5:138643213chr5:138643367ENST00000394805015496_5710848.0DomainRRM 2
TgeneMATR3chr5:138643213chr5:138643367ENST00000503811014398_4730560.0DomainRRM 1
TgeneMATR3chr5:138643213chr5:138643367ENST00000503811014496_5710560.0DomainRRM 2
TgeneMATR3chr5:138643213chr5:138643367ENST00000509990017398_4730848.0DomainRRM 1
TgeneMATR3chr5:138643213chr5:138643367ENST00000509990017496_5710848.0DomainRRM 2
TgeneMATR3chr5:138643213chr5:138643367ENST00000361059018710_7180848.0MotifNuclear localization signal
TgeneMATR3chr5:138643213chr5:138643367ENST00000394805015710_7180848.0MotifNuclear localization signal
TgeneMATR3chr5:138643213chr5:138643367ENST00000503811014710_7180560.0MotifNuclear localization signal
TgeneMATR3chr5:138643213chr5:138643367ENST00000509990017710_7180848.0MotifNuclear localization signal
TgeneMATR3chr5:138643213chr5:138643367ENST00000361059018801_8320848.0Zinc fingerMatrin-type
TgeneMATR3chr5:138643213chr5:138643367ENST00000394805015801_8320848.0Zinc fingerMatrin-type
TgeneMATR3chr5:138643213chr5:138643367ENST00000503811014801_8320560.0Zinc fingerMatrin-type
TgeneMATR3chr5:138643213chr5:138643367ENST00000509990017801_8320848.0Zinc fingerMatrin-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMATR3chr5:138643213chr5:138643367ENST00000361059+118398_4730848.0DomainRRM 1
HgeneMATR3chr5:138643213chr5:138643367ENST00000361059+118496_5710848.0DomainRRM 2
HgeneMATR3chr5:138643213chr5:138643367ENST00000394805+115398_4730848.0DomainRRM 1
HgeneMATR3chr5:138643213chr5:138643367ENST00000394805+115496_5710848.0DomainRRM 2
HgeneMATR3chr5:138643213chr5:138643367ENST00000503811+114398_4730560.0DomainRRM 1
HgeneMATR3chr5:138643213chr5:138643367ENST00000503811+114496_5710560.0DomainRRM 2
HgeneMATR3chr5:138643213chr5:138643367ENST00000509990+117398_4730848.0DomainRRM 1
HgeneMATR3chr5:138643213chr5:138643367ENST00000509990+117496_5710848.0DomainRRM 2
HgeneMATR3chr5:138643213chr5:138643367ENST00000361059+118710_7180848.0MotifNuclear localization signal
HgeneMATR3chr5:138643213chr5:138643367ENST00000394805+115710_7180848.0MotifNuclear localization signal
HgeneMATR3chr5:138643213chr5:138643367ENST00000503811+114710_7180560.0MotifNuclear localization signal
HgeneMATR3chr5:138643213chr5:138643367ENST00000509990+117710_7180848.0MotifNuclear localization signal
HgeneMATR3chr5:138643213chr5:138643367ENST00000361059+118801_8320848.0Zinc fingerMatrin-type
HgeneMATR3chr5:138643213chr5:138643367ENST00000394805+115801_8320848.0Zinc fingerMatrin-type
HgeneMATR3chr5:138643213chr5:138643367ENST00000503811+114801_8320560.0Zinc fingerMatrin-type
HgeneMATR3chr5:138643213chr5:138643367ENST00000509990+117801_8320848.0Zinc fingerMatrin-type


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Fusion Gene Sequence for MATR3-MATR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MATR3-MATR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MATR3-MATR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MATR3-MATR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource