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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAVS-STK24 (FusionGDB2 ID:51934)

Fusion Gene Summary for MAVS-STK24

check button Fusion gene summary
Fusion gene informationFusion gene name: MAVS-STK24
Fusion gene ID: 51934
HgeneTgene
Gene symbol

MAVS

STK24

Gene ID

57506

8428

Gene namemitochondrial antiviral signaling proteinserine/threonine kinase 24
SynonymsCARDIF|IPS-1|IPS1|VISAHEL-S-95|MST3|MST3B|STE20|STK3
Cytomap

20p13

13q32.2

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial antiviral-signaling proteinCARD adapter inducing interferon betaCARD adaptor inducing IFN-betaIFN-B promoter stimulator 1interferon beta promoter stimulator protein 1putative NF-kappa-B-activating protein 031Nvirus-induced signaling adserine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3
Modification date2020031320200313
UniProtAcc

Q7Z434

.
Ensembl transtripts involved in fusion geneENST00000358134, ENST00000416600, 
ENST00000428216, 		ENST00000397517, 
ENST00000539966, ENST00000376547, 
ENST00000481288, 
Fusion gene scores* DoF score4 X 4 X 2=3215 X 8 X 8=960
# samples 418
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(18/960*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAVS [Title/Abstract] AND STK24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAVS(3845435)-STK24(99171727), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAVS

GO:0001934

positive regulation of protein phosphorylation

16127453

HgeneMAVS

GO:0002230

positive regulation of defense response to virus by host

16127453

HgeneMAVS

GO:0032727

positive regulation of interferon-alpha production

16127453

HgeneMAVS

GO:0032728

positive regulation of interferon-beta production

16127453

HgeneMAVS

GO:0032757

positive regulation of interleukin-8 production

16127453

HgeneMAVS

GO:0032760

positive regulation of tumor necrosis factor production

16127453

HgeneMAVS

GO:0042307

positive regulation of protein import into nucleus

18818105

HgeneMAVS

GO:0045071

negative regulation of viral genome replication

20451243

HgeneMAVS

GO:0045944

positive regulation of transcription by RNA polymerase II

16127453|18818105

HgeneMAVS

GO:0051091

positive regulation of DNA-binding transcription factor activity

16127453|18818105

HgeneMAVS

GO:0051607

defense response to virus

20451243

HgeneMAVS

GO:0060340

positive regulation of type I interferon-mediated signaling pathway

16127453|20451243

HgeneMAVS

GO:0071651

positive regulation of chemokine (C-C motif) ligand 5 production

16127453

HgeneMAVS

GO:0071660

positive regulation of IP-10 production

16127453

TgeneSTK24

GO:0006468

protein phosphorylation

19604147

TgeneSTK24

GO:0042542

response to hydrogen peroxide

22291017

TgeneSTK24

GO:0046777

protein autophosphorylation

17046825|17657516


check buttonFusion gene breakpoints across MAVS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STK24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1770-01AMAVSchr20

3845435

+STK24chr13

99171727

-


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Fusion Gene ORF analysis for MAVS-STK24

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000358134ENST00000397517MAVSchr20

3845435

+STK24chr13

99171727

-
3UTR-3CDSENST00000358134ENST00000539966MAVSchr20

3845435

+STK24chr13

99171727

-
3UTR-5UTRENST00000358134ENST00000376547MAVSchr20

3845435

+STK24chr13

99171727

-
3UTR-5UTRENST00000358134ENST00000481288MAVSchr20

3845435

+STK24chr13

99171727

-
5CDS-5UTRENST00000416600ENST00000376547MAVSchr20

3845435

+STK24chr13

99171727

-
5CDS-5UTRENST00000416600ENST00000481288MAVSchr20

3845435

+STK24chr13

99171727

-
5CDS-5UTRENST00000428216ENST00000376547MAVSchr20

3845435

+STK24chr13

99171727

-
5CDS-5UTRENST00000428216ENST00000481288MAVSchr20

3845435

+STK24chr13

99171727

-
In-frameENST00000416600ENST00000397517MAVSchr20

3845435

+STK24chr13

99171727

-
In-frameENST00000416600ENST00000539966MAVSchr20

3845435

+STK24chr13

99171727

-
In-frameENST00000428216ENST00000397517MAVSchr20

3845435

+STK24chr13

99171727

-
In-frameENST00000428216ENST00000539966MAVSchr20

3845435

+STK24chr13

99171727

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000416600MAVSchr203845435+ENST00000397517STK24chr1399171727-534011141662367733
ENST00000416600MAVSchr203845435+ENST00000539966STK24chr1399171727-256911141662310714
ENST00000428216MAVSchr203845435+ENST00000397517STK24chr1399171727-551212861282539803
ENST00000428216MAVSchr203845435+ENST00000539966STK24chr1399171727-274112861282482784

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000416600ENST00000397517MAVSchr203845435+STK24chr1399171727-0.0016677660.9983322
ENST00000416600ENST00000539966MAVSchr203845435+STK24chr1399171727-0.0148373290.9851627
ENST00000428216ENST00000397517MAVSchr203845435+STK24chr1399171727-0.0014684720.99853146
ENST00000428216ENST00000539966MAVSchr203845435+STK24chr1399171727-0.0088756790.99112433

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Fusion Genomic Features for MAVS-STK24


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAVS-STK24


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:3845435/chr13:99171727)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAVS

Q7Z434

.
FUNCTION: Required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:20127681, PubMed:21170385). Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:25636800, PubMed:20127681, PubMed:21170385, PubMed:20628368). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:25636800}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAVSchr20:3845435chr13:99171727ENST00000358134+45103_153328360.3333333333333Compositional biasNote=Pro-rich
HgeneMAVSchr20:3845435chr13:99171727ENST00000416600+56103_153245400.0Compositional biasNote=Pro-rich
HgeneMAVSchr20:3845435chr13:99171727ENST00000428216+67103_153386541.0Compositional biasNote=Pro-rich
TgeneSTK24chr20:3845435chr13:99171727ENST0000037654701136_28626444.0DomainProtein kinase
TgeneSTK24chr20:3845435chr13:99171727ENST0000039751701136_28614432.0DomainProtein kinase
TgeneSTK24chr20:3845435chr13:99171727ENST00000376547011278_29226444.0MotifNote=Bipartite nuclear localization signal
TgeneSTK24chr20:3845435chr13:99171727ENST00000376547011335_38626444.0MotifNote=Nuclear export signal (NES)
TgeneSTK24chr20:3845435chr13:99171727ENST00000397517011278_29214432.0MotifNote=Bipartite nuclear localization signal
TgeneSTK24chr20:3845435chr13:99171727ENST00000397517011335_38614432.0MotifNote=Nuclear export signal (NES)
TgeneSTK24chr20:3845435chr13:99171727ENST00000376547011112_11426444.0Nucleotide bindingNote=ATP
TgeneSTK24chr20:3845435chr13:99171727ENST0000037654701142_5026444.0Nucleotide bindingNote=ATP
TgeneSTK24chr20:3845435chr13:99171727ENST00000397517011112_11414432.0Nucleotide bindingNote=ATP
TgeneSTK24chr20:3845435chr13:99171727ENST0000039751701142_5014432.0Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAVSchr20:3845435chr13:99171727ENST00000358134+45439_442328360.3333333333333MotifpLxIS motif
HgeneMAVSchr20:3845435chr13:99171727ENST00000416600+56439_442245400.0MotifpLxIS motif
HgeneMAVSchr20:3845435chr13:99171727ENST00000428216+67439_442386541.0MotifpLxIS motif
HgeneMAVSchr20:3845435chr13:99171727ENST00000358134+451_513328360.3333333333333Topological domainCytoplasmic
HgeneMAVSchr20:3845435chr13:99171727ENST00000358134+45535_540328360.3333333333333Topological domainMitochondrial intermembrane
HgeneMAVSchr20:3845435chr13:99171727ENST00000416600+561_513245400.0Topological domainCytoplasmic
HgeneMAVSchr20:3845435chr13:99171727ENST00000416600+56535_540245400.0Topological domainMitochondrial intermembrane
HgeneMAVSchr20:3845435chr13:99171727ENST00000428216+671_513386541.0Topological domainCytoplasmic
HgeneMAVSchr20:3845435chr13:99171727ENST00000428216+67535_540386541.0Topological domainMitochondrial intermembrane
HgeneMAVSchr20:3845435chr13:99171727ENST00000358134+45514_534328360.3333333333333TransmembraneHelical
HgeneMAVSchr20:3845435chr13:99171727ENST00000416600+56514_534245400.0TransmembraneHelical
HgeneMAVSchr20:3845435chr13:99171727ENST00000428216+67514_534386541.0TransmembraneHelical


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Fusion Gene Sequence for MAVS-STK24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51934_51934_1_MAVS-STK24_MAVS_chr20_3845435_ENST00000416600_STK24_chr13_99171727_ENST00000397517_length(transcript)=5340nt_BP=1114nt
GCTGCGGGAAGGGTCCTGGGCCCCGGGCGGCGGTCGCCAGGTCTCAGGGCCGGGGGTACCCGAGTCTCGTTTCCTCTCAGTCCATCCACC
CTTCATGGGGCCAGAGCCCTCTCTCCAGAATCTGAGCAGCAATGCCGTTTGCTGAAGACAAGACCTATAAGTATATCTGCCGCAATTTCA
GCAATTTTTGCAATGTGGATGTTGTAGAGATTCTGCCTTACCTGCCCTGCCTCACAGCAAGAGACCAGGGACCTCGGACCGTCCCCCAGA
CCCACTGGAGCCACCGTCACTTCCTGCTGAGAGGCCAGGGCCCCCCACACCTGCTGCGGCCCACAGCATCCCCTACAACAGCTGCAGAGA
GAAGGAGCCAAGTTACCCCATGCCTGTCCAGGAGACCCAGGCGCCAGAGTCCCCAGGAGAGAATTCAGAGCAAGCCCTGCAGACGCTCAG
CCCCAGAGCCATCCCAAGGAATCCAGATGGTGGCCCCCTGGAGTCCTCCTCTGACCTGGCAGCCCTCAGCCCTCTGACCTCCAGCGGGCA
TCAGGAGCAGGACACAGAACTGGGCAGTACCCACACAGCAGGTGCGACCTCCAGCCTCACACCATCCCGTGGGCCTGTGTCTCCATCTGT
CTCCTTCCAGCCCCTGGCCCGTTCCACCCCCAGGGCAAGCCGCTTGCCTGGACCCACAGGGTCAGTTGTATCTACTGGCACCTCCTTCTC
CTCCTCATCCCCTGGCTTGGCCTCTGCAGGGGCTGCAGAGGGTAAACAGGGTGCAGAGAGTGACCAGGCCGAGCCTATCATCTGCTCCAG
TGGGGCAGAGGCACCTGCCAACTCTCTGCCCTCCAAAGTGCCTACCACCTTGATGCCTGTGAACACAGTGGCCCTGAAAGTGCCTGCCAA
CCCAGCATCTGTCAGCACAGTGCCCTCCAAGTTGCCAACTAGCTCAAAGCCCCCTGGTGCAGTGCCTTCTAATGCGCTCACCAATCCAGC
ACCATCCAAATTGCCCATCAACTCAACCCGTGCTGGCATGGTGCCATCCAAAGTGCCTACTAGCATGGTGCTCACCAAGGTGTCTGCCAG
CACAGTCCCCACTGACGGGAGCAGCAGAAATGAGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAGAGAAAATTGGGAAGGG
CTCCTTTGGAGAGGTGTTCAAAGGCATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGGAAGAAGCTGAAGATGA
GATAGAGGACATTCAACAAGAAATCACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGATCCTATCTGAAGGATAC
AAAATTATGGATAATAATGGAATATCTTGGTGGAGGCTCCGCACTAGATCTATTAGAACCTGGCCCATTAGATGAAACCCAGATCGCTAC
TATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAACGTCCTGCTGTC
TGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACACCTTCGTGGGCACCCC
ATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGC
AAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTA
CAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTT
TATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTC
GAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGA
TCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTG
TTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCG
AGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCT
AAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTT
AAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACAC
AGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTTTATTTTATTAC
TTTTGTTTTTAATTTTAACCATAGTGCACATATTCCAGGAAAGTGTCTTTAAAAACAAAAACAAACCCTGAAATGTATATTTGGGATTAT
GATAAGGCAACTAAAGACATGAAACCTCAGGTATCCTGCTTTAAGTTGATAACTCCCTCTGGGAGCTGGAGAATCGCTCTGGTGGATGGG
TGTACAGATTTGTATATAATGTCATTTTTACGGAAACCCTTTCGGCGTGCATAAGGAATCACTGTGTACAAACTGGCCAAGTGCTTCTGT
AGATAACGTCAGTGGAGTAAATATTCGACAGGCCATAACTTGAGTCTATTGCCTTGCCTTTATTACATGTACATTTTGAATTCTGTGACC
AGTGATTTGGGTTTTATTTTGTATTTGCAGGGTTTGTCATTAATAATTAATGCCCCTCTCTTACAGAACACTCCTATTTGTACCTCAACA
AATGCAAATTTTCCCCGTTTGCCCTACGCCCCTTTTGGTACACCTAGAGGTTGATTTCCTTTTTCATCGATGGTACTATTTCTTAGTGTT
TTAAATTGGAACATATCTTGCCTCATGAAGCTTTAAATTATAATTTTCAGTTTCTCCCCATGAAGCGCTCTCGTCTGACATTTGTTTGGA
ATCGTGCCACTGCTGGTCTGCGCCAGATGTACCGTCCTTTCCAATACGATTTTCTGTTGCACCTTGTAGTGGATTCTGCATATCATCTTT
CCCACCTAAAAATGTCTGAATGCTTACACAAATAAATTTTATAACACGCTTATTTTGCATACTCCTTGAAATGTGACTCTTCAGAGGACA
GGGCACCTGCTGTGTATGTGTGGCCGTGCGTGTGTACTCGTGGCTGTGTGTGTGTGATGAGACACTTTGGAAGACTCCAGGGAGAAGTCC
CCAGGCCTGGAGCTGCCGAGTGCCCAGGTCAGCGCCCTGGACTGCTTGCGCACTTGCTCACCGAGATGATGCAGTTGGAGGTTGCTGATC
TGTGCGATTGCTGTAGCGGTTGCCGGGGACCTTAAGAGTTATTTTGCTTCTCTGGAAGGGGCCTATGCTTGCTAGGCAGGCAGCCAGTGT
GTCTGTTTTTCTTGGTTTGCTGTGGGACCTTGCTTGGCGAGGGGGAAAATCTCTGGGTTTCTGGAGTGGGAGGGTTCGTGCAGCAGCTGT
TGACTGGTACATGAAGCATTCTTTTATGTTTGTTGAAGCTGATGATTGACATCTCCCGTGGGTGTGCCAGTTCTTGTGGAGTTAAGACAG
GATTTTTGGAAGCAAGGAAGTTAGTGGGTGAGCTTGGGGATGTAGCTCAGCTATCTGCTGGTCTAGTGGCCTCTAAGCTATAGGGAGGGG
ACAGAGCCCTGAGCTACAGATGCTTGAGTGGGTTATTGTGTCGGTTTGCTAGTGCAGTCTGGTTTTTAAGCTCTAAAATTGAGGTATTTT
ATTAGAAGTGGATTTGGGTTGAACTCTTAATTTGTATAAGGGATATATTTTGGTTGGGGAAATAGAACTGAGTTGCTAATTCTTATTGTA
CTCATTACTCCATACAAGAATGTTATGTTGAATAATAAAATTGGAGAAGATTTCATTTTGTGTTTCCAGGGAGTATTCTGTGTGGGGAAC
TGTTTCCTTACGTGAGGCCGGCGGCATAAGTCAAAGATGAGTTTTGTCCTTGCGAATCACACAGATTGAGTCTGTGTTCCCCAGGGTGTG
CCGTTACCTGATTTTTAAGTGAGCCAGGGCGGACAGCAGCTTTTCTGATTTACAGAGTTCTTCAGATTTACAAATGGACAATGACATCAC
AGTTTTTAGCACTGAAGCCAGTCTCATGCTAGTAACAGTGGGTGAGCCGCTCGAGGGACTGGGTTCTAATGAATACTGGTATGAACGGGG
AGTCTCTGCAGTCGCCAGACAAATCATACTCAGCCCCTTCCCCCGTAGAGCAACAAGTGGTTCTTTTAGAGTTGACTGGCAGCATTTCCT
GTCGGGGGAGGTGGGGTTTGATGGAGTTAGAAAGCTCGCCTCTGTGTACATTCTCTCCTGGGCTGTTACTTTCTGTAGACGCACAAAATC
AGCCCCAATGTTTTTAAGGGCATCTTAGCCAAGGAAGCTGGCTTTTGTGTCGCCACTTCCAGGCCTGCATTAAGAGAGAGCCCAGGCACC
AGGGCTACCACTGGAACCTGCCTCAGCGTCAACTGCTGCTGGTCTGTAGCCAGGCCCAGCCTTTGAGACGGGTTTACTGTCACCAGTAGC
CTCTCAGTGCCAGCCCTGAGCTGCTCCTGGCTCAGCTGCCCAGAGCCTGCAGCCTGGGGAGGTACTCAGCCTCTGGGAGACGAGGGCCGT
GGACTGGGTGGCTGGTAGCTCCTGCGTTTTTGAGCTGTGTCCTGGCTGGCTGCTGCCAATGAGGTGGACACCAGTGTGGTTTGGGGTGCA
CTGGCCACTTCTTGCTGGGTTCTGATTTTCTTGGAAGTGCATCTGCCTTCCTTATCCAATAGTTTTATCCCTGCATTGCTCTTGTGAAGT
GGCTGGTTTGGTTCTGTATGTAGCATTTTGTACCTTTCCTCTGGCAAAACACTGTCAGTTTATAAACATTTTTTATATTTCCCTCCTTTA
AAAACAGCTTGTGTATTTCTGCTATAAAATGTGTCAGCAAAGGCAGAGTGACCTAATAGGGCATGTTCTTAAGCACAGGGACTGTATCAT

>51934_51934_1_MAVS-STK24_MAVS_chr20_3845435_ENST00000416600_STK24_chr13_99171727_ENST00000397517_length(amino acids)=733AA_BP=316
MPQFQQFLQCGCCRDSALPALPHSKRPGTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQA
LQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVST
GTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNA
LTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNENLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLE
EAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAA
NVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPT
LEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFT
IREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRL

--------------------------------------------------------------
>51934_51934_2_MAVS-STK24_MAVS_chr20_3845435_ENST00000416600_STK24_chr13_99171727_ENST00000539966_length(transcript)=2569nt_BP=1114nt
GCTGCGGGAAGGGTCCTGGGCCCCGGGCGGCGGTCGCCAGGTCTCAGGGCCGGGGGTACCCGAGTCTCGTTTCCTCTCAGTCCATCCACC
CTTCATGGGGCCAGAGCCCTCTCTCCAGAATCTGAGCAGCAATGCCGTTTGCTGAAGACAAGACCTATAAGTATATCTGCCGCAATTTCA
GCAATTTTTGCAATGTGGATGTTGTAGAGATTCTGCCTTACCTGCCCTGCCTCACAGCAAGAGACCAGGGACCTCGGACCGTCCCCCAGA
CCCACTGGAGCCACCGTCACTTCCTGCTGAGAGGCCAGGGCCCCCCACACCTGCTGCGGCCCACAGCATCCCCTACAACAGCTGCAGAGA
GAAGGAGCCAAGTTACCCCATGCCTGTCCAGGAGACCCAGGCGCCAGAGTCCCCAGGAGAGAATTCAGAGCAAGCCCTGCAGACGCTCAG
CCCCAGAGCCATCCCAAGGAATCCAGATGGTGGCCCCCTGGAGTCCTCCTCTGACCTGGCAGCCCTCAGCCCTCTGACCTCCAGCGGGCA
TCAGGAGCAGGACACAGAACTGGGCAGTACCCACACAGCAGGTGCGACCTCCAGCCTCACACCATCCCGTGGGCCTGTGTCTCCATCTGT
CTCCTTCCAGCCCCTGGCCCGTTCCACCCCCAGGGCAAGCCGCTTGCCTGGACCCACAGGGTCAGTTGTATCTACTGGCACCTCCTTCTC
CTCCTCATCCCCTGGCTTGGCCTCTGCAGGGGCTGCAGAGGGTAAACAGGGTGCAGAGAGTGACCAGGCCGAGCCTATCATCTGCTCCAG
TGGGGCAGAGGCACCTGCCAACTCTCTGCCCTCCAAAGTGCCTACCACCTTGATGCCTGTGAACACAGTGGCCCTGAAAGTGCCTGCCAA
CCCAGCATCTGTCAGCACAGTGCCCTCCAAGTTGCCAACTAGCTCAAAGCCCCCTGGTGCAGTGCCTTCTAATGCGCTCACCAATCCAGC
ACCATCCAAATTGCCCATCAACTCAACCCGTGCTGGCATGGTGCCATCCAAAGTGCCTACTAGCATGGTGCTCACCAAGGTGTCTGCCAG
CACAGTCCCCACTGACGGGAGCAGCAGAAATGAGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAGAGAAAATTGGGAAGGG
CTCCTTTGGAGAGGTGTTCAAAGGCATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGGAAGAAGCTGAAGATGA
GATAGAGGACATTCAACAAGAAATCACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGATCCTATCTGAAGTTAGA
ACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAGAAGAAAATCCA
CAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAGCTGACAGACAC
CCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCGAAGGCAGACAT
CTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCC
AAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAG
ACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAA
GAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTC
TGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGAT
GAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTG
CGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGC
CCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTT
TCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCAC
CCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCT

>51934_51934_2_MAVS-STK24_MAVS_chr20_3845435_ENST00000416600_STK24_chr13_99171727_ENST00000539966_length(amino acids)=714AA_BP=316
MPQFQQFLQCGCCRDSALPALPHSKRPGTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQA
LQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVST
GTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNA
LTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNENLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLE
EAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAG
QLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNK
EPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDL

--------------------------------------------------------------
>51934_51934_3_MAVS-STK24_MAVS_chr20_3845435_ENST00000428216_STK24_chr13_99171727_ENST00000397517_length(transcript)=5512nt_BP=1286nt
GCGGGAAGGGTCCTGGGCCCCGGGCGGCGGTCGCCAGGTCTCAGGGCCGGGGGTACCCGAGTCTCGTTTCCTCTCAGTCCATCCACCCTT
CATGGGGCCAGAGCCCTCTCTCCAGAATCTGAGCAGCAATGCCGTTTGCTGAAGACAAGACCTATAAGTATATCTGCCGCAATTTCAGCA
ATTTTTGCAATGTGGATGTTGTAGAGATTCTGCCTTACCTGCCCTGCCTCACAGCAAGAGACCAGGATCGACTGCGGGCCACCTGCACAC
TCTCAGGGAACCGGGACACCCTCTGGCATCTCTTCAATACCCTTCAGCGGCGGCCCGGCTGGGTGGAGTACTTCATTGCGGCACTGAGGG
GCTGTGAGCTAGTTGATCTCGCGGACGAAGTGGCCTCTGTCTACCAGAGCTACCAGCCTCGGACCTCGGACCGTCCCCCAGACCCACTGG
AGCCACCGTCACTTCCTGCTGAGAGGCCAGGGCCCCCCACACCTGCTGCGGCCCACAGCATCCCCTACAACAGCTGCAGAGAGAAGGAGC
CAAGTTACCCCATGCCTGTCCAGGAGACCCAGGCGCCAGAGTCCCCAGGAGAGAATTCAGAGCAAGCCCTGCAGACGCTCAGCCCCAGAG
CCATCCCAAGGAATCCAGATGGTGGCCCCCTGGAGTCCTCCTCTGACCTGGCAGCCCTCAGCCCTCTGACCTCCAGCGGGCATCAGGAGC
AGGACACAGAACTGGGCAGTACCCACACAGCAGGTGCGACCTCCAGCCTCACACCATCCCGTGGGCCTGTGTCTCCATCTGTCTCCTTCC
AGCCCCTGGCCCGTTCCACCCCCAGGGCAAGCCGCTTGCCTGGACCCACAGGGTCAGTTGTATCTACTGGCACCTCCTTCTCCTCCTCAT
CCCCTGGCTTGGCCTCTGCAGGGGCTGCAGAGGGTAAACAGGGTGCAGAGAGTGACCAGGCCGAGCCTATCATCTGCTCCAGTGGGGCAG
AGGCACCTGCCAACTCTCTGCCCTCCAAAGTGCCTACCACCTTGATGCCTGTGAACACAGTGGCCCTGAAAGTGCCTGCCAACCCAGCAT
CTGTCAGCACAGTGCCCTCCAAGTTGCCAACTAGCTCAAAGCCCCCTGGTGCAGTGCCTTCTAATGCGCTCACCAATCCAGCACCATCCA
AATTGCCCATCAACTCAACCCGTGCTGGCATGGTGCCATCCAAAGTGCCTACTAGCATGGTGCTCACCAAGGTGTCTGCCAGCACAGTCC
CCACTGACGGGAGCAGCAGAAATGAGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAGAGAAAATTGGGAAGGGCTCCTTTG
GAGAGGTGTTCAAAGGCATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGGAAGAAGCTGAAGATGAGATAGAGG
ACATTCAACAAGAAATCACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGATCCTATCTGAAGGATACAAAATTAT
GGATAATAATGGAATATCTTGGTGGAGGCTCCGCACTAGATCTATTAGAACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAA
GAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATG
GCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGA
TGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGG
AACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAAC
CCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTAC
GCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCG
AGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGA
ATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTA
CAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCA
TCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTG
GAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCA
ACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCA
CTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTTTATTTTATTACTTTTGTTT
TTAATTTTAACCATAGTGCACATATTCCAGGAAAGTGTCTTTAAAAACAAAAACAAACCCTGAAATGTATATTTGGGATTATGATAAGGC
AACTAAAGACATGAAACCTCAGGTATCCTGCTTTAAGTTGATAACTCCCTCTGGGAGCTGGAGAATCGCTCTGGTGGATGGGTGTACAGA
TTTGTATATAATGTCATTTTTACGGAAACCCTTTCGGCGTGCATAAGGAATCACTGTGTACAAACTGGCCAAGTGCTTCTGTAGATAACG
TCAGTGGAGTAAATATTCGACAGGCCATAACTTGAGTCTATTGCCTTGCCTTTATTACATGTACATTTTGAATTCTGTGACCAGTGATTT
GGGTTTTATTTTGTATTTGCAGGGTTTGTCATTAATAATTAATGCCCCTCTCTTACAGAACACTCCTATTTGTACCTCAACAAATGCAAA
TTTTCCCCGTTTGCCCTACGCCCCTTTTGGTACACCTAGAGGTTGATTTCCTTTTTCATCGATGGTACTATTTCTTAGTGTTTTAAATTG
GAACATATCTTGCCTCATGAAGCTTTAAATTATAATTTTCAGTTTCTCCCCATGAAGCGCTCTCGTCTGACATTTGTTTGGAATCGTGCC
ACTGCTGGTCTGCGCCAGATGTACCGTCCTTTCCAATACGATTTTCTGTTGCACCTTGTAGTGGATTCTGCATATCATCTTTCCCACCTA
AAAATGTCTGAATGCTTACACAAATAAATTTTATAACACGCTTATTTTGCATACTCCTTGAAATGTGACTCTTCAGAGGACAGGGCACCT
GCTGTGTATGTGTGGCCGTGCGTGTGTACTCGTGGCTGTGTGTGTGTGATGAGACACTTTGGAAGACTCCAGGGAGAAGTCCCCAGGCCT
GGAGCTGCCGAGTGCCCAGGTCAGCGCCCTGGACTGCTTGCGCACTTGCTCACCGAGATGATGCAGTTGGAGGTTGCTGATCTGTGCGAT
TGCTGTAGCGGTTGCCGGGGACCTTAAGAGTTATTTTGCTTCTCTGGAAGGGGCCTATGCTTGCTAGGCAGGCAGCCAGTGTGTCTGTTT
TTCTTGGTTTGCTGTGGGACCTTGCTTGGCGAGGGGGAAAATCTCTGGGTTTCTGGAGTGGGAGGGTTCGTGCAGCAGCTGTTGACTGGT
ACATGAAGCATTCTTTTATGTTTGTTGAAGCTGATGATTGACATCTCCCGTGGGTGTGCCAGTTCTTGTGGAGTTAAGACAGGATTTTTG
GAAGCAAGGAAGTTAGTGGGTGAGCTTGGGGATGTAGCTCAGCTATCTGCTGGTCTAGTGGCCTCTAAGCTATAGGGAGGGGACAGAGCC
CTGAGCTACAGATGCTTGAGTGGGTTATTGTGTCGGTTTGCTAGTGCAGTCTGGTTTTTAAGCTCTAAAATTGAGGTATTTTATTAGAAG
TGGATTTGGGTTGAACTCTTAATTTGTATAAGGGATATATTTTGGTTGGGGAAATAGAACTGAGTTGCTAATTCTTATTGTACTCATTAC
TCCATACAAGAATGTTATGTTGAATAATAAAATTGGAGAAGATTTCATTTTGTGTTTCCAGGGAGTATTCTGTGTGGGGAACTGTTTCCT
TACGTGAGGCCGGCGGCATAAGTCAAAGATGAGTTTTGTCCTTGCGAATCACACAGATTGAGTCTGTGTTCCCCAGGGTGTGCCGTTACC
TGATTTTTAAGTGAGCCAGGGCGGACAGCAGCTTTTCTGATTTACAGAGTTCTTCAGATTTACAAATGGACAATGACATCACAGTTTTTA
GCACTGAAGCCAGTCTCATGCTAGTAACAGTGGGTGAGCCGCTCGAGGGACTGGGTTCTAATGAATACTGGTATGAACGGGGAGTCTCTG
CAGTCGCCAGACAAATCATACTCAGCCCCTTCCCCCGTAGAGCAACAAGTGGTTCTTTTAGAGTTGACTGGCAGCATTTCCTGTCGGGGG
AGGTGGGGTTTGATGGAGTTAGAAAGCTCGCCTCTGTGTACATTCTCTCCTGGGCTGTTACTTTCTGTAGACGCACAAAATCAGCCCCAA
TGTTTTTAAGGGCATCTTAGCCAAGGAAGCTGGCTTTTGTGTCGCCACTTCCAGGCCTGCATTAAGAGAGAGCCCAGGCACCAGGGCTAC
CACTGGAACCTGCCTCAGCGTCAACTGCTGCTGGTCTGTAGCCAGGCCCAGCCTTTGAGACGGGTTTACTGTCACCAGTAGCCTCTCAGT
GCCAGCCCTGAGCTGCTCCTGGCTCAGCTGCCCAGAGCCTGCAGCCTGGGGAGGTACTCAGCCTCTGGGAGACGAGGGCCGTGGACTGGG
TGGCTGGTAGCTCCTGCGTTTTTGAGCTGTGTCCTGGCTGGCTGCTGCCAATGAGGTGGACACCAGTGTGGTTTGGGGTGCACTGGCCAC
TTCTTGCTGGGTTCTGATTTTCTTGGAAGTGCATCTGCCTTCCTTATCCAATAGTTTTATCCCTGCATTGCTCTTGTGAAGTGGCTGGTT
TGGTTCTGTATGTAGCATTTTGTACCTTTCCTCTGGCAAAACACTGTCAGTTTATAAACATTTTTTATATTTCCCTCCTTTAAAAACAGC
TTGTGTATTTCTGCTATAAAATGTGTCAGCAAAGGCAGAGTGACCTAATAGGGCATGTTCTTAAGCACAGGGACTGTATCATGCAGGGGC

>51934_51934_3_MAVS-STK24_MAVS_chr20_3845435_ENST00000428216_STK24_chr13_99171727_ENST00000397517_length(amino acids)=803AA_BP=386
MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVAS
VYQSYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSPRAIPRNPDGGPLES
SSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGK
QGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVP
SKVPTSMVLTKVSASTVPTDGSSRNENLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD
SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQ
LTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKE
PSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLD

--------------------------------------------------------------
>51934_51934_4_MAVS-STK24_MAVS_chr20_3845435_ENST00000428216_STK24_chr13_99171727_ENST00000539966_length(transcript)=2741nt_BP=1286nt
GCGGGAAGGGTCCTGGGCCCCGGGCGGCGGTCGCCAGGTCTCAGGGCCGGGGGTACCCGAGTCTCGTTTCCTCTCAGTCCATCCACCCTT
CATGGGGCCAGAGCCCTCTCTCCAGAATCTGAGCAGCAATGCCGTTTGCTGAAGACAAGACCTATAAGTATATCTGCCGCAATTTCAGCA
ATTTTTGCAATGTGGATGTTGTAGAGATTCTGCCTTACCTGCCCTGCCTCACAGCAAGAGACCAGGATCGACTGCGGGCCACCTGCACAC
TCTCAGGGAACCGGGACACCCTCTGGCATCTCTTCAATACCCTTCAGCGGCGGCCCGGCTGGGTGGAGTACTTCATTGCGGCACTGAGGG
GCTGTGAGCTAGTTGATCTCGCGGACGAAGTGGCCTCTGTCTACCAGAGCTACCAGCCTCGGACCTCGGACCGTCCCCCAGACCCACTGG
AGCCACCGTCACTTCCTGCTGAGAGGCCAGGGCCCCCCACACCTGCTGCGGCCCACAGCATCCCCTACAACAGCTGCAGAGAGAAGGAGC
CAAGTTACCCCATGCCTGTCCAGGAGACCCAGGCGCCAGAGTCCCCAGGAGAGAATTCAGAGCAAGCCCTGCAGACGCTCAGCCCCAGAG
CCATCCCAAGGAATCCAGATGGTGGCCCCCTGGAGTCCTCCTCTGACCTGGCAGCCCTCAGCCCTCTGACCTCCAGCGGGCATCAGGAGC
AGGACACAGAACTGGGCAGTACCCACACAGCAGGTGCGACCTCCAGCCTCACACCATCCCGTGGGCCTGTGTCTCCATCTGTCTCCTTCC
AGCCCCTGGCCCGTTCCACCCCCAGGGCAAGCCGCTTGCCTGGACCCACAGGGTCAGTTGTATCTACTGGCACCTCCTTCTCCTCCTCAT
CCCCTGGCTTGGCCTCTGCAGGGGCTGCAGAGGGTAAACAGGGTGCAGAGAGTGACCAGGCCGAGCCTATCATCTGCTCCAGTGGGGCAG
AGGCACCTGCCAACTCTCTGCCCTCCAAAGTGCCTACCACCTTGATGCCTGTGAACACAGTGGCCCTGAAAGTGCCTGCCAACCCAGCAT
CTGTCAGCACAGTGCCCTCCAAGTTGCCAACTAGCTCAAAGCCCCCTGGTGCAGTGCCTTCTAATGCGCTCACCAATCCAGCACCATCCA
AATTGCCCATCAACTCAACCCGTGCTGGCATGGTGCCATCCAAAGTGCCTACTAGCATGGTGCTCACCAAGGTGTCTGCCAGCACAGTCC
CCACTGACGGGAGCAGCAGAAATGAGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAGAGAAAATTGGGAAGGGCTCCTTTG
GAGAGGTGTTCAAAGGCATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGGAAGAAGCTGAAGATGAGATAGAGG
ACATTCAACAAGAAATCACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGATCCTATCTGAAGTTAGAACCTGGCC
CATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAGAAGAAAATCCACAGAGACA
TTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAGCTGACAGACACCCAGATCA
AAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCGAAGGCAGACATCTGGTCCC
TGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACA
ACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTG
CTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGA
AGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACT
GGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACA
TCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGA
ACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCG
TGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTT
TCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGC
CAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAG

>51934_51934_4_MAVS-STK24_MAVS_chr20_3845435_ENST00000428216_STK24_chr13_99171727_ENST00000539966_length(amino acids)=784AA_BP=386
MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVAS
VYQSYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSPRAIPRNPDGGPLES
SSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGK
QGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVP
SKVPTSMVLTKVSASTVPTDGSSRNENLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD
SPYVTKYYGSYLKLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMA
PEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRN
AKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MAVS-STK24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMAVSchr20:3845435chr13:99171727ENST00000358134+45143_147328.3333333333333360.3333333333333TRAF2
HgeneMAVSchr20:3845435chr13:99171727ENST00000416600+56143_147245.0400.0TRAF2
HgeneMAVSchr20:3845435chr13:99171727ENST00000428216+67143_147386.0541.0TRAF2
HgeneMAVSchr20:3845435chr13:99171727ENST00000358134+45153_158328.3333333333333360.3333333333333TRAF6
HgeneMAVSchr20:3845435chr13:99171727ENST00000416600+56153_158245.0400.0TRAF6
HgeneMAVSchr20:3845435chr13:99171727ENST00000428216+67153_158386.0541.0TRAF6


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMAVSchr20:3845435chr13:99171727ENST00000358134+45455_460328.3333333333333360.3333333333333TRAF6
HgeneMAVSchr20:3845435chr13:99171727ENST00000416600+56455_460245.0400.0TRAF6
HgeneMAVSchr20:3845435chr13:99171727ENST00000428216+67455_460386.0541.0TRAF6


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAVS-STK24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAVS-STK24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource