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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAZ-MAZ (FusionGDB2 ID:51943)

Fusion Gene Summary for MAZ-MAZ

check button Fusion gene summary
Fusion gene informationFusion gene name: MAZ-MAZ
Fusion gene ID: 51943
HgeneTgene
Gene symbol

MAZ

MAZ

Gene ID

4150

4150

Gene nameMYC associated zinc finger proteinMYC associated zinc finger protein
SynonymsPUR1|Pur-1|SAF-1|SAF-2|SAF-3|ZF87|ZNF801|Zif87PUR1|Pur-1|SAF-1|SAF-2|SAF-3|ZF87|ZNF801|Zif87
Cytomap

16p11.2

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionmyc-associated zinc finger proteinMAZIpurine-binding transcription factorserum amyloid A activating factor 1serum amyloid A activating factor 2transcription factor Zif87zinc finger protein 801zinc-finger protein, 87 kilodaltonsmyc-associated zinc finger proteinMAZIpurine-binding transcription factorserum amyloid A activating factor 1serum amyloid A activating factor 2transcription factor Zif87zinc finger protein 801zinc-finger protein, 87 kilodaltons
Modification date2020031320200313
UniProtAcc

P56270

P56270

Ensembl transtripts involved in fusion geneENST00000219782, ENST00000322945, 
ENST00000545521, ENST00000562337, 
ENST00000563402, ENST00000566906, 
ENST00000568282, ENST00000568516, 
ENST00000568544, ENST00000569978, 
ENST00000219782, ENST00000568282, 
ENST00000568544, ENST00000568516, 
ENST00000569978, ENST00000545521, 
ENST00000563402, ENST00000566906, 
ENST00000322945, ENST00000562337, 
Fusion gene scores* DoF score4 X 4 X 1=165 X 5 X 2=50
# samples 45
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/50*10)=0
Context

PubMed: MAZ [Title/Abstract] AND MAZ [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAZ(29818157)-MAZ(29821524), # samples:1
Anticipated loss of major functional domain due to fusion event.MAZ-MAZ seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
MAZ-MAZ seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MAZ-MAZ seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
MAZ-MAZ seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
MAZ-MAZ seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
MAZ-MAZ seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAZ

GO:0006367

transcription initiation from RNA polymerase II promoter

1502157

HgeneMAZ

GO:0006369

termination of RNA polymerase II transcription

1502157

HgeneMAZ

GO:0008284

positive regulation of cell proliferation

25487955

HgeneMAZ

GO:0010628

positive regulation of gene expression

25487955

HgeneMAZ

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

25487955

HgeneMAZ

GO:0030335

positive regulation of cell migration

25487955

HgeneMAZ

GO:0045893

positive regulation of transcription, DNA-templated

25487955

HgeneMAZ

GO:0051897

positive regulation of protein kinase B signaling

25487955

HgeneMAZ

GO:2001234

negative regulation of apoptotic signaling pathway

25487955

TgeneMAZ

GO:0006367

transcription initiation from RNA polymerase II promoter

1502157

TgeneMAZ

GO:0006369

termination of RNA polymerase II transcription

1502157

TgeneMAZ

GO:0008284

positive regulation of cell proliferation

25487955

TgeneMAZ

GO:0010628

positive regulation of gene expression

25487955

TgeneMAZ

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

25487955

TgeneMAZ

GO:0030335

positive regulation of cell migration

25487955

TgeneMAZ

GO:0045893

positive regulation of transcription, DNA-templated

25487955

TgeneMAZ

GO:0051897

positive regulation of protein kinase B signaling

25487955

TgeneMAZ

GO:2001234

negative regulation of apoptotic signaling pathway

25487955


check buttonFusion gene breakpoints across MAZ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAZ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI651289MAZchr16

29818157

-MAZchr16

29821524

+


Top

Fusion Gene ORF analysis for MAZ-MAZ

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000219782ENST00000219782MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000219782ENST00000568282MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000219782ENST00000568544MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000322945ENST00000219782MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000322945ENST00000568282MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000322945ENST00000568544MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000545521ENST00000219782MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000545521ENST00000568282MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000545521ENST00000568544MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000562337ENST00000219782MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000562337ENST00000568282MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000562337ENST00000568544MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000563402ENST00000219782MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000563402ENST00000568282MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000563402ENST00000568544MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000566906ENST00000219782MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000566906ENST00000568282MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-3UTRENST00000566906ENST00000568544MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-intronENST00000219782ENST00000568516MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-intronENST00000219782ENST00000569978MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-intronENST00000322945ENST00000568516MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-intronENST00000322945ENST00000569978MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-intronENST00000545521ENST00000568516MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-intronENST00000545521ENST00000569978MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-intronENST00000562337ENST00000568516MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-intronENST00000562337ENST00000569978MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-intronENST00000563402ENST00000568516MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-intronENST00000563402ENST00000569978MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-intronENST00000566906ENST00000568516MAZchr16

29818157

-MAZchr16

29821524

+
5CDS-intronENST00000566906ENST00000569978MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000219782ENST00000545521MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000219782ENST00000563402MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000219782ENST00000566906MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000322945ENST00000545521MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000322945ENST00000563402MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000322945ENST00000566906MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000545521ENST00000545521MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000545521ENST00000563402MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000545521ENST00000566906MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000562337ENST00000545521MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000562337ENST00000563402MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000562337ENST00000566906MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000563402ENST00000545521MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000563402ENST00000563402MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000563402ENST00000566906MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000566906ENST00000545521MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000566906ENST00000563402MAZchr16

29818157

-MAZchr16

29821524

+
Frame-shiftENST00000566906ENST00000566906MAZchr16

29818157

-MAZchr16

29821524

+
In-frameENST00000219782ENST00000322945MAZchr16

29818157

-MAZchr16

29821524

+
In-frameENST00000219782ENST00000562337MAZchr16

29818157

-MAZchr16

29821524

+
In-frameENST00000322945ENST00000322945MAZchr16

29818157

-MAZchr16

29821524

+
In-frameENST00000322945ENST00000562337MAZchr16

29818157

-MAZchr16

29821524

+
In-frameENST00000545521ENST00000322945MAZchr16

29818157

-MAZchr16

29821524

+
In-frameENST00000545521ENST00000562337MAZchr16

29818157

-MAZchr16

29821524

+
In-frameENST00000562337ENST00000322945MAZchr16

29818157

-MAZchr16

29821524

+
In-frameENST00000562337ENST00000562337MAZchr16

29818157

-MAZchr16

29821524

+
In-frameENST00000563402ENST00000322945MAZchr16

29818157

-MAZchr16

29821524

+
In-frameENST00000563402ENST00000562337MAZchr16

29818157

-MAZchr16

29821524

+
In-frameENST00000566906ENST00000322945MAZchr16

29818157

-MAZchr16

29821524

+
In-frameENST00000566906ENST00000562337MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568282ENST00000322945MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568282ENST00000545521MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568282ENST00000562337MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568282ENST00000563402MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568282ENST00000566906MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568516ENST00000322945MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568516ENST00000545521MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568516ENST00000562337MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568516ENST00000563402MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568516ENST00000566906MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568544ENST00000322945MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568544ENST00000545521MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568544ENST00000562337MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568544ENST00000563402MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000568544ENST00000566906MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000569978ENST00000322945MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000569978ENST00000545521MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000569978ENST00000562337MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000569978ENST00000563402MAZchr16

29818157

-MAZchr16

29821524

+
intron-3CDSENST00000569978ENST00000566906MAZchr16

29818157

-MAZchr16

29821524

+
intron-3UTRENST00000568282ENST00000219782MAZchr16

29818157

-MAZchr16

29821524

+
intron-3UTRENST00000568282ENST00000568282MAZchr16

29818157

-MAZchr16

29821524

+
intron-3UTRENST00000568282ENST00000568544MAZchr16

29818157

-MAZchr16

29821524

+
intron-3UTRENST00000568516ENST00000219782MAZchr16

29818157

-MAZchr16

29821524

+
intron-3UTRENST00000568516ENST00000568282MAZchr16

29818157

-MAZchr16

29821524

+
intron-3UTRENST00000568516ENST00000568544MAZchr16

29818157

-MAZchr16

29821524

+
intron-3UTRENST00000568544ENST00000219782MAZchr16

29818157

-MAZchr16

29821524

+
intron-3UTRENST00000568544ENST00000568282MAZchr16

29818157

-MAZchr16

29821524

+
intron-3UTRENST00000568544ENST00000568544MAZchr16

29818157

-MAZchr16

29821524

+
intron-3UTRENST00000569978ENST00000219782MAZchr16

29818157

-MAZchr16

29821524

+
intron-3UTRENST00000569978ENST00000568282MAZchr16

29818157

-MAZchr16

29821524

+
intron-3UTRENST00000569978ENST00000568544MAZchr16

29818157

-MAZchr16

29821524

+
intron-intronENST00000568282ENST00000568516MAZchr16

29818157

-MAZchr16

29821524

+
intron-intronENST00000568282ENST00000569978MAZchr16

29818157

-MAZchr16

29821524

+
intron-intronENST00000568516ENST00000568516MAZchr16

29818157

-MAZchr16

29821524

+
intron-intronENST00000568516ENST00000569978MAZchr16

29818157

-MAZchr16

29821524

+
intron-intronENST00000568544ENST00000568516MAZchr16

29818157

-MAZchr16

29821524

+
intron-intronENST00000568544ENST00000569978MAZchr16

29818157

-MAZchr16

29821524

+
intron-intronENST00000569978ENST00000568516MAZchr16

29818157

-MAZchr16

29821524

+
intron-intronENST00000569978ENST00000569978MAZchr16

29818157

-MAZchr16

29821524

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MAZ-MAZ


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MAZ-MAZ


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:29818157/chr16:29821524)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAZ

P56270

MAZ

P56270

FUNCTION: Transcriptional regulator, potentially with dual roles in transcription initiation and termination. {ECO:0000303|PubMed:1502157}.; FUNCTION: [Isoform 1]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157). Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157). {ECO:0000269|PubMed:12270922, ECO:0000269|PubMed:1502157}.; FUNCTION: [Isoform 2]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922). {ECO:0000269|PubMed:12270922}.; FUNCTION: [Isoform 3]: Binds DNA and functions as a transcriptional activator. {ECO:0000269|PubMed:19583771}.FUNCTION: Transcriptional regulator, potentially with dual roles in transcription initiation and termination. {ECO:0000303|PubMed:1502157}.; FUNCTION: [Isoform 1]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157). Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157). {ECO:0000269|PubMed:12270922, ECO:0000269|PubMed:1502157}.; FUNCTION: [Isoform 2]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922). {ECO:0000269|PubMed:12270922}.; FUNCTION: [Isoform 3]: Binds DNA and functions as a transcriptional activator. {ECO:0000269|PubMed:19583771}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAZchr16:29818157chr16:29821524ENST0000021978206133_1390757.3333333333334Compositional biasNote=Poly-Pro
TgeneMAZchr16:29818157chr16:29821524ENST0000021978206157_1610757.3333333333334Compositional biasNote=Poly-Ala
TgeneMAZchr16:29818157chr16:29821524ENST0000021978206245_2490757.3333333333334Compositional biasNote=Poly-Gly
TgeneMAZchr16:29818157chr16:29821524ENST0000021978206435_4490757.3333333333334Compositional biasNote=Poly-Ala
TgeneMAZchr16:29818157chr16:29821524ENST000002197820696_1080757.3333333333334Compositional biasNote=Poly-Ala
TgeneMAZchr16:29818157chr16:29821524ENST0000032294505133_1390478.0Compositional biasNote=Poly-Pro
TgeneMAZchr16:29818157chr16:29821524ENST0000032294505157_1610478.0Compositional biasNote=Poly-Ala
TgeneMAZchr16:29818157chr16:29821524ENST0000032294505245_2490478.0Compositional biasNote=Poly-Gly
TgeneMAZchr16:29818157chr16:29821524ENST0000032294505435_4490478.0Compositional biasNote=Poly-Ala
TgeneMAZchr16:29818157chr16:29821524ENST000003229450596_1080478.0Compositional biasNote=Poly-Ala
TgeneMAZchr16:29818157chr16:29821524ENST0000054552106133_1390455.0Compositional biasNote=Poly-Pro
TgeneMAZchr16:29818157chr16:29821524ENST0000054552106157_1610455.0Compositional biasNote=Poly-Ala
TgeneMAZchr16:29818157chr16:29821524ENST0000054552106245_2490455.0Compositional biasNote=Poly-Gly
TgeneMAZchr16:29818157chr16:29821524ENST0000054552106435_4490455.0Compositional biasNote=Poly-Ala
TgeneMAZchr16:29818157chr16:29821524ENST000005455210696_1080455.0Compositional biasNote=Poly-Ala
TgeneMAZchr16:29818157chr16:29821524ENST0000021978206190_2120757.3333333333334Zinc fingerC2H2-type 1
TgeneMAZchr16:29818157chr16:29821524ENST0000021978206279_3010757.3333333333334Zinc fingerC2H2-type 2
TgeneMAZchr16:29818157chr16:29821524ENST0000021978206307_3290757.3333333333334Zinc fingerC2H2-type 3
TgeneMAZchr16:29818157chr16:29821524ENST0000021978206337_3600757.3333333333334Zinc fingerC2H2-type 4
TgeneMAZchr16:29818157chr16:29821524ENST0000021978206366_3880757.3333333333334Zinc fingerC2H2-type 5
TgeneMAZchr16:29818157chr16:29821524ENST0000021978206392_4130757.3333333333334Zinc fingerC2H2-type 6%3B atypical
TgeneMAZchr16:29818157chr16:29821524ENST0000032294505190_2120478.0Zinc fingerC2H2-type 1
TgeneMAZchr16:29818157chr16:29821524ENST0000032294505279_3010478.0Zinc fingerC2H2-type 2
TgeneMAZchr16:29818157chr16:29821524ENST0000032294505307_3290478.0Zinc fingerC2H2-type 3
TgeneMAZchr16:29818157chr16:29821524ENST0000032294505337_3600478.0Zinc fingerC2H2-type 4
TgeneMAZchr16:29818157chr16:29821524ENST0000032294505366_3880478.0Zinc fingerC2H2-type 5
TgeneMAZchr16:29818157chr16:29821524ENST0000032294505392_4130478.0Zinc fingerC2H2-type 6%3B atypical
TgeneMAZchr16:29818157chr16:29821524ENST0000054552106190_2120455.0Zinc fingerC2H2-type 1
TgeneMAZchr16:29818157chr16:29821524ENST0000054552106279_3010455.0Zinc fingerC2H2-type 2
TgeneMAZchr16:29818157chr16:29821524ENST0000054552106307_3290455.0Zinc fingerC2H2-type 3
TgeneMAZchr16:29818157chr16:29821524ENST0000054552106337_3600455.0Zinc fingerC2H2-type 4
TgeneMAZchr16:29818157chr16:29821524ENST0000054552106366_3880455.0Zinc fingerC2H2-type 5
TgeneMAZchr16:29818157chr16:29821524ENST0000054552106392_4130455.0Zinc fingerC2H2-type 6%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAZchr16:29818157chr16:29821524ENST00000219782-16133_1390757.3333333333334Compositional biasNote=Poly-Pro
HgeneMAZchr16:29818157chr16:29821524ENST00000219782-16157_1610757.3333333333334Compositional biasNote=Poly-Ala
HgeneMAZchr16:29818157chr16:29821524ENST00000219782-16245_2490757.3333333333334Compositional biasNote=Poly-Gly
HgeneMAZchr16:29818157chr16:29821524ENST00000219782-16435_4490757.3333333333334Compositional biasNote=Poly-Ala
HgeneMAZchr16:29818157chr16:29821524ENST00000219782-1696_1080757.3333333333334Compositional biasNote=Poly-Ala
HgeneMAZchr16:29818157chr16:29821524ENST00000322945-15133_1390478.0Compositional biasNote=Poly-Pro
HgeneMAZchr16:29818157chr16:29821524ENST00000322945-15157_1610478.0Compositional biasNote=Poly-Ala
HgeneMAZchr16:29818157chr16:29821524ENST00000322945-15245_2490478.0Compositional biasNote=Poly-Gly
HgeneMAZchr16:29818157chr16:29821524ENST00000322945-15435_4490478.0Compositional biasNote=Poly-Ala
HgeneMAZchr16:29818157chr16:29821524ENST00000322945-1596_1080478.0Compositional biasNote=Poly-Ala
HgeneMAZchr16:29818157chr16:29821524ENST00000545521-16133_1390455.0Compositional biasNote=Poly-Pro
HgeneMAZchr16:29818157chr16:29821524ENST00000545521-16157_1610455.0Compositional biasNote=Poly-Ala
HgeneMAZchr16:29818157chr16:29821524ENST00000545521-16245_2490455.0Compositional biasNote=Poly-Gly
HgeneMAZchr16:29818157chr16:29821524ENST00000545521-16435_4490455.0Compositional biasNote=Poly-Ala
HgeneMAZchr16:29818157chr16:29821524ENST00000545521-1696_1080455.0Compositional biasNote=Poly-Ala
HgeneMAZchr16:29818157chr16:29821524ENST00000219782-16190_2120757.3333333333334Zinc fingerC2H2-type 1
HgeneMAZchr16:29818157chr16:29821524ENST00000219782-16279_3010757.3333333333334Zinc fingerC2H2-type 2
HgeneMAZchr16:29818157chr16:29821524ENST00000219782-16307_3290757.3333333333334Zinc fingerC2H2-type 3
HgeneMAZchr16:29818157chr16:29821524ENST00000219782-16337_3600757.3333333333334Zinc fingerC2H2-type 4
HgeneMAZchr16:29818157chr16:29821524ENST00000219782-16366_3880757.3333333333334Zinc fingerC2H2-type 5
HgeneMAZchr16:29818157chr16:29821524ENST00000219782-16392_4130757.3333333333334Zinc fingerC2H2-type 6%3B atypical
HgeneMAZchr16:29818157chr16:29821524ENST00000322945-15190_2120478.0Zinc fingerC2H2-type 1
HgeneMAZchr16:29818157chr16:29821524ENST00000322945-15279_3010478.0Zinc fingerC2H2-type 2
HgeneMAZchr16:29818157chr16:29821524ENST00000322945-15307_3290478.0Zinc fingerC2H2-type 3
HgeneMAZchr16:29818157chr16:29821524ENST00000322945-15337_3600478.0Zinc fingerC2H2-type 4
HgeneMAZchr16:29818157chr16:29821524ENST00000322945-15366_3880478.0Zinc fingerC2H2-type 5
HgeneMAZchr16:29818157chr16:29821524ENST00000322945-15392_4130478.0Zinc fingerC2H2-type 6%3B atypical
HgeneMAZchr16:29818157chr16:29821524ENST00000545521-16190_2120455.0Zinc fingerC2H2-type 1
HgeneMAZchr16:29818157chr16:29821524ENST00000545521-16279_3010455.0Zinc fingerC2H2-type 2
HgeneMAZchr16:29818157chr16:29821524ENST00000545521-16307_3290455.0Zinc fingerC2H2-type 3
HgeneMAZchr16:29818157chr16:29821524ENST00000545521-16337_3600455.0Zinc fingerC2H2-type 4
HgeneMAZchr16:29818157chr16:29821524ENST00000545521-16366_3880455.0Zinc fingerC2H2-type 5
HgeneMAZchr16:29818157chr16:29821524ENST00000545521-16392_4130455.0Zinc fingerC2H2-type 6%3B atypical


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Fusion Gene Sequence for MAZ-MAZ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAZ-MAZ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAZ-MAZ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAZ-MAZ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource