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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MB21D2-FGF12 (FusionGDB2 ID:51953)

Fusion Gene Summary for MB21D2-FGF12

Fusion gene summary

Fusion gene information	Fusion gene name: MB21D2-FGF12
	Fusion gene ID: 51953
		Hgene	Tgene
	Gene symbol	MB21D2	FGF12
	Gene ID	151963	2257
	Gene name	Mab-21 domain containing 2	fibroblast growth factor 12
	Synonyms	C3orf59	EIEE47\|FGF12B\|FHF1
	Cytomap	3q29	3q28-q29
	Type of gene	protein-coding	protein-coding
	Description	protein MB21D2mab-21 domain-containing protein 2	fibroblast growth factor 12fibroblast growth factor 12Bfibroblast growth factor FGF-12bfibroblast growth factor homologous factor 1myocyte-activating factor
	Modification date	20200313	20200315
	UniProtAcc	Q8IYB1	P61328
	Ensembl transtripts involved in fusion gene	ENST00000392452,	ENST00000430714, ENST00000466144, ENST00000264730, ENST00000445105, ENST00000450716, ENST00000454309,
Fusion gene scores	* DoF score	4 X 2 X 5=40	12 X 7 X 9=756
	# samples	5	14
	** MAII score	log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(14/756*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MB21D2 [Title/Abstract] AND FGF12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MB21D2(192635419)-FGF12(192078327), # samples:3
Anticipated loss of major functional domain due to fusion event.	MB21D2-FGF12 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MB21D2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FGF12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AC-A7VB-01A	MB21D2	chr3	192635419	-	FGF12	chr3	192078327	-
ChimerDB4	GBM	TCGA-06-1804-01A	MB21D2	chr3	192635419	-	FGF12	chr3	191888445	-
ChimerDB4	LUSC	TCGA-60-2711	MB21D2	chr3	192635419	-	FGF12	chr3	192078327	-
ChimerDB4	STAD	TCGA-BR-A4IY-01A	MB21D2	chr3	192635419	-	FGF12	chr3	192078327	-

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Fusion Gene ORF analysis for MB21D2-FGF12

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000392452	ENST00000430714	MB21D2	chr3	192635419	-	FGF12	chr3	192078327	-
5CDS-intron	ENST00000392452	ENST00000466144	MB21D2	chr3	192635419	-	FGF12	chr3	192078327	-
5CDS-intron	ENST00000392452	ENST00000466144	MB21D2	chr3	192635419	-	FGF12	chr3	191888445	-
Frame-shift	ENST00000392452	ENST00000264730	MB21D2	chr3	192635419	-	FGF12	chr3	192078327	-
Frame-shift	ENST00000392452	ENST00000445105	MB21D2	chr3	192635419	-	FGF12	chr3	192078327	-
Frame-shift	ENST00000392452	ENST00000450716	MB21D2	chr3	192635419	-	FGF12	chr3	192078327	-
Frame-shift	ENST00000392452	ENST00000454309	MB21D2	chr3	192635419	-	FGF12	chr3	192078327	-
In-frame	ENST00000392452	ENST00000264730	MB21D2	chr3	192635419	-	FGF12	chr3	191888445	-
In-frame	ENST00000392452	ENST00000430714	MB21D2	chr3	192635419	-	FGF12	chr3	191888445	-
In-frame	ENST00000392452	ENST00000445105	MB21D2	chr3	192635419	-	FGF12	chr3	191888445	-
In-frame	ENST00000392452	ENST00000450716	MB21D2	chr3	192635419	-	FGF12	chr3	191888445	-
In-frame	ENST00000392452	ENST00000454309	MB21D2	chr3	192635419	-	FGF12	chr3	191888445	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000392452	MB21D2	chr3	192635419	-	ENST00000445105	FGF12	chr3	191888445	-	5464	532	120	575	151
ENST00000392452	MB21D2	chr3	192635419	-	ENST00000264730	FGF12	chr3	191888445	-	2964	532	120	575	151
ENST00000392452	MB21D2	chr3	192635419	-	ENST00000454309	FGF12	chr3	191888445	-	2350	532	120	575	151
ENST00000392452	MB21D2	chr3	192635419	-	ENST00000450716	FGF12	chr3	191888445	-	881	532	120	575	151
ENST00000392452	MB21D2	chr3	192635419	-	ENST00000430714	FGF12	chr3	191888445	-	871	532	120	575	151

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000392452	ENST00000445105	MB21D2	chr3	192635419	-	FGF12	chr3	191888445	-	0.3448181	0.6551819
ENST00000392452	ENST00000264730	MB21D2	chr3	192635419	-	FGF12	chr3	191888445	-	0.124771476	0.8752286
ENST00000392452	ENST00000454309	MB21D2	chr3	192635419	-	FGF12	chr3	191888445	-	0.2976442	0.7023558
ENST00000392452	ENST00000450716	MB21D2	chr3	192635419	-	FGF12	chr3	191888445	-	0.11497752	0.8850225
ENST00000392452	ENST00000430714	MB21D2	chr3	192635419	-	FGF12	chr3	191888445	-	0.12497499	0.875025

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Fusion Genomic Features for MB21D2-FGF12

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MB21D2-FGF12

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:192635419/chr3:192078327)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MB21D2 Q8IYB1	FGF12 P61328
	FUNCTION: Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. {ECO:0000269\|PubMed:27164707}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FGF12

chr3:192635419

chr3:191888445

ENST00000264730

11_38

182.0

Motif

Bipartite nuclear localization signal

Tgene

FGF12

chr3:192635419

chr3:191888445

ENST00000445105

11_38

182.0

Motif

Bipartite nuclear localization signal

Tgene

FGF12

chr3:192635419

chr3:191888445

ENST00000450716

11_38

182.0

Motif

Bipartite nuclear localization signal

Tgene

FGF12

chr3:192635419

chr3:191888445

ENST00000454309

11_38

138

244.0

Motif

Bipartite nuclear localization signal

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Fusion Gene Sequence for MB21D2-FGF12

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>51953_51953_1_MB21D2-FGF12_MB21D2_chr3_192635419_ENST00000392452_FGF12_chr3_191888445_ENST00000264730_length(transcript)=2964nt_BP=532nt
AGTTGGCTCTACGACCGCCGTTGCCGCTGCCAGAGAGGGCCAGGGCAGGGCAGGGACGCGCAGCATCGGGGCGGGCGTGGGGCCGGAGAA
AAGGGTGTCGGGGCCACACACGCACCCTCGCTGCAGTCCAGCTCCTCCCGAAGCTCGCACGCCCAGAGCGCACGGAGCGGGGGACTGCCC
GCCCAGACGCCCGCCCGCCAACCCGCCCACGAGCCGGGGCCAAAGCCTGGGAGCCTGCGAGGGGAGGAGGCCCAGGGGGGCGGGGTGGGG
GGCGGGGGTGGGTGCCGCGCTGCCGCGGAGCTGCTACTCGGCGCGTTTTGCATGAAGATGGCGGCTCCCACCGCCAACAAGGCAGCCTCC
CTGGGCTGTAACAACAAGCCTGCGTTCCCGGAGCTGGATTTCAGGTCGGGAGCTCGGGTGGAGGAATTGAACAAACTCATCCAAGAATTT
ACGAAGCACGACCAGCGGGAATACGACGACCAGAGAGCGCTGGAGATTCACACAGCCAAGGATTTCATCTTTTCCATGCTGGGATGTTTT
CACTCCAGAATGCAAATTCAAGGAATCTGTGTTTGAAAACTACTATGTGATCTATTCTTCCACACTGTACCGCCAGCAAGAATCAGGCCG
AGCTTGGTTTCTGGGACTCAATAAAGAAGGTCAAATTATGAAGGGGAACAGAGTGAAGAAAACCAAGCCCTCATCACATTTTGTACCGAA
ACCTATTGAAGTGTGTATGTACAGAGAACCATCGCTACATGAAATTGGAGAAAAACAAGGGCGTTCAAGGAAAAGTTCTGGAACACCAAC
CATGAATGGAGGCAAAGTTGTGAATCAAGATTCAACATAGCTGAGAACTCTCCCCTTCTTCCCTCTCTCATCCCTTCCCCTTCCCTTCCT
TCCCATTTACCCATTTCCTTCCAGTAAATCCACCCAAGGAGAGGAAAATAAAATGACAACGCAAGACCTAGTGGCTAAGATTCTGCACTC
AAAATCTTCCTTTGTGTAGGACAAGAAAATTGAACCAAAGCTTGCTTGTTGCAATGTGGTAGAAAATTCACGTGCACAAAGATTAGCACA
CTTAAAAGCAAAGGAAAAAATAAATCAGAACTCCATAAATATTAAATTAAACTGTATTGTTATTAGTAGAAGGCTAATTGTAATGAAGAC
ATTAATAAAGATGAAATAAACTTATTACTTTAAAGGAAAGGATTTGGAGAATTGAACTCACAAACTGATGTTATATACTCAATAGCTTAA
ACTCATGATAATGCTGCGATGTGTGGTTTTGCTTGATTTTGTATTTTATTTGGGCATCTGGAATTGACACACCATTACATTCTGTTTGCA
GGATTTTTTTTGTAACCATGAAATTGAACATTTCCAAATTATAAACTATGTTAATACCTATAAAATATATAGCCAGGAACCATTTATCAT
CAAGAAAAGTGTAAGAAATTATTTTTGAGATGTAATTTAAGATTGTTTTATGTAAAAGGAAAATCTTGTATGGCATCGAATAGCCTTAAT
GAGTTTAATTCTTTCACAAAAATGATTTCAAATTATCCTAGAGTATAACATTTTTATCAAAGATATTATTTCCGGAGTTCTTCTTTCTTT
CTTTTTTTTTTTTTTTTAGTAATTTAGCAAAAACATTACTGTTCTAATGCTGAAGTGACTTTTGCCAGTGCCATGTCCAGGTGGTGAGGT
ATAAGTTACTTGCTCTTAGCATTTGGTCTGATTTTTTTGCTTTGTGGACACCTTTGAGAGTATCCACAAAGCAATGTCTCAGGTGTGGAC
ACCTGAGAGCATGTTTTAGAAAGCTTTGTACCCTGTCTTGTGGCAGGAAAGAAAGAACAGGGGTTTTACATAAGGAAATAAGTCCTAGGA
AATTAGTCAACGCAAATTGCATTTGCGTTTGTACCTTACCACAGTCTTATATTGTTTTTTAAACTCTGCCATGAAATTTGGAGACATGAC
TGTGAAATTCCTAACTTACTATCTTACAAAGCCAGTAGCTAATTTGTTGCTCTATGTATGATCCTGTTACAAGTCCAGTTTGCAATTCAT
TTGTTTCCTAGAACACAGAAGGGTACCAGTAATACACTAAATTTTCAAGGTGTGTAGAGAAATAATATGGAATTAGCAGCTATGACTCCA
ACAGACAGGATTGTGTGAGCAGCTGAAAGGAGCAAAAAAGAACTCAGTGTAAGAGAAGGCACATACATAGTTAAGAATACTAAAGTATTT
TTAAAAATCAAGGAAGAAATAAATGTTACACAATTTGCATTGGAATAAATAGATCTATTTAGTCCTACAAATCAGGAGTGGTGTAGAGAC
ATCCAAATTTAAAGAAAAAAAAACACAAAACAGAATGTTAAAAAATGTATGCAGATTTATGGATATTATCAATGAGAAGACATAGCATGT
AACTTCTCCTATATCTCTACTGTCCAGCATGTATTGTTCCAAATATGACTCCCTAAAATATATACACTTTGCAGAAGCTCTAGGCCCTCA
CCTCAAACCTTGCCATTGGTTGCCGTATTTCAAGGTCAATATAGTTTCCCTCACTTTACACAATCATTATTCTTCAATAGTGGACCATAT
CCTTCACCAGGTATCCTATTTCTGTTATCTAGAGGTTAGCAGAAAATGAAATGAAGGAATTTCCCTAAGCAGTTGGGAAGAACAAATTGT
ATGCATGTAGGCAAAGATTTTGAAGATACATTTGCAAGAGATATTTGTTTAACCAAAATATTTGGAAAGTAACAAATAAAGACATTTAAA
TTTTCTAAAAATGGACTTGCTCTTCTAGGAAAAGAATACCCCTGGGGCAAAAATATAACTCTAGCTGTATTTCTTCTTGTCACTCTTGAT

>51953_51953_1_MB21D2-FGF12_MB21D2_chr3_192635419_ENST00000392452_FGF12_chr3_191888445_ENST00000264730_length(amino acids)=151AA_BP=
MQSSSSRSSHAQSARSGGLPAQTPARQPAHEPGPKPGSLRGEEAQGGGVGGGGGCRAAAELLLGAFCMKMAAPTANKAASLGCNNKPAFP

--------------------------------------------------------------
>51953_51953_2_MB21D2-FGF12_MB21D2_chr3_192635419_ENST00000392452_FGF12_chr3_191888445_ENST00000430714_length(transcript)=871nt_BP=532nt
AGTTGGCTCTACGACCGCCGTTGCCGCTGCCAGAGAGGGCCAGGGCAGGGCAGGGACGCGCAGCATCGGGGCGGGCGTGGGGCCGGAGAA
AAGGGTGTCGGGGCCACACACGCACCCTCGCTGCAGTCCAGCTCCTCCCGAAGCTCGCACGCCCAGAGCGCACGGAGCGGGGGACTGCCC
GCCCAGACGCCCGCCCGCCAACCCGCCCACGAGCCGGGGCCAAAGCCTGGGAGCCTGCGAGGGGAGGAGGCCCAGGGGGGCGGGGTGGGG
GGCGGGGGTGGGTGCCGCGCTGCCGCGGAGCTGCTACTCGGCGCGTTTTGCATGAAGATGGCGGCTCCCACCGCCAACAAGGCAGCCTCC
CTGGGCTGTAACAACAAGCCTGCGTTCCCGGAGCTGGATTTCAGGTCGGGAGCTCGGGTGGAGGAATTGAACAAACTCATCCAAGAATTT
ACGAAGCACGACCAGCGGGAATACGACGACCAGAGAGCGCTGGAGATTCACACAGCCAAGGATTTCATCTTTTCCATGCTGGGATGTTTT
CACTCCAGAATGCAAATTCAAGGAATCTGTGTTTGAAAACTACTATGTGATCTATTCTTCCACACTGTACCGCCAGCAAGAATCAGGCCG
AGCTTGGTTTCTGGGACTCAATAAAGAAGGTCAAATTATGAAGGGGAACAGAGTGAAGAAAACCAAGCCCTCATCACATTTTGTACCGAA
ACCTATTGAAGTGTGTATGTACAGAGAACCATCGCTACATGAAATTGGAGAAAAACAAGGGCGTTCAAGGAAAAGTTCTGGAACACCAAC

>51953_51953_2_MB21D2-FGF12_MB21D2_chr3_192635419_ENST00000392452_FGF12_chr3_191888445_ENST00000430714_length(amino acids)=151AA_BP=
MQSSSSRSSHAQSARSGGLPAQTPARQPAHEPGPKPGSLRGEEAQGGGVGGGGGCRAAAELLLGAFCMKMAAPTANKAASLGCNNKPAFP

--------------------------------------------------------------
>51953_51953_3_MB21D2-FGF12_MB21D2_chr3_192635419_ENST00000392452_FGF12_chr3_191888445_ENST00000445105_length(transcript)=5464nt_BP=532nt
AGTTGGCTCTACGACCGCCGTTGCCGCTGCCAGAGAGGGCCAGGGCAGGGCAGGGACGCGCAGCATCGGGGCGGGCGTGGGGCCGGAGAA
AAGGGTGTCGGGGCCACACACGCACCCTCGCTGCAGTCCAGCTCCTCCCGAAGCTCGCACGCCCAGAGCGCACGGAGCGGGGGACTGCCC
GCCCAGACGCCCGCCCGCCAACCCGCCCACGAGCCGGGGCCAAAGCCTGGGAGCCTGCGAGGGGAGGAGGCCCAGGGGGGCGGGGTGGGG
GGCGGGGGTGGGTGCCGCGCTGCCGCGGAGCTGCTACTCGGCGCGTTTTGCATGAAGATGGCGGCTCCCACCGCCAACAAGGCAGCCTCC
CTGGGCTGTAACAACAAGCCTGCGTTCCCGGAGCTGGATTTCAGGTCGGGAGCTCGGGTGGAGGAATTGAACAAACTCATCCAAGAATTT
ACGAAGCACGACCAGCGGGAATACGACGACCAGAGAGCGCTGGAGATTCACACAGCCAAGGATTTCATCTTTTCCATGCTGGGATGTTTT
CACTCCAGAATGCAAATTCAAGGAATCTGTGTTTGAAAACTACTATGTGATCTATTCTTCCACACTGTACCGCCAGCAAGAATCAGGCCG
AGCTTGGTTTCTGGGACTCAATAAAGAAGGTCAAATTATGAAGGGGAACAGAGTGAAGAAAACCAAGCCCTCATCACATTTTGTACCGAA
ACCTATTGAAGTGTGTATGTACAGAGAACCATCGCTACATGAAATTGGAGAAAAACAAGGGCGTTCAAGGAAAAGTTCTGGAACACCAAC
CATGAATGGAGGCAAAGTTGTGAATCAAGATTCAACATAGCTGAGAACTCTCCCCTTCTTCCCTCTCTCATCCCTTCCCCTTCCCTTCCT
TCCCATTTACCCATTTCCTTCCAGTAAATCCACCCAAGGAGAGGAAAATAAAATGACAACGCAAGACCTAGTGGCTAAGATTCTGCACTC
AAAATCTTCCTTTGTGTAGGACAAGAAAATTGAACCAAAGCTTGCTTGTTGCAATGTGGTAGAAAATTCACGTGCACAAAGATTAGCACA
CTTAAAAGCAAAGGAAAAAATAAATCAGAACTCCATAAATATTAAATTAAACTGTATTGTTATTAGTAGAAGGCTAATTGTAATGAAGAC
ATTAATAAAGATGAAATAAACTTATTACTTTAAAGGAAAGGATTTGGAGAATTGAACTCACAAACTGATGTTATATACTCAATAGCTTAA
ACTCATGATAATGCTGCGATGTGTGGTTTTGCTTGATTTTGTATTTTATTTGGGCATCTGGAATTGACACACCATTACATTCTGTTTGCA
GGATTTTTTTTGTAACCATGAAATTGAACATTTCCAAATTATAAACTATGTTAATACCTATAAAATATATAGCCAGGAACCATTTATCAT
CAAGAAAAGTGTAAGAAATTATTTTTGAGATGTAATTTAAGATTGTTTTATGTAAAAGGAAAATCTTGTATGGCATCGAATAGCCTTAAT
GAGTTTAATTCTTTCACAAAAATGATTTCAAATTATCCTAGAGTATAACATTTTTATCAAAGATATTATTTCCGGAGTTCTTCTTTCTTT
CTTTTTTTTTTTTTTTTAGTAATTTAGCAAAAACATTACTGTTCTAATGCTGAAGTGACTTTTGCCAGTGCCATGTCCAGGTGGTGAGGT
ATAAGTTACTTGCTCTTAGCATTTGGTCTGATTTTTTTGCTTTGTGGACACCTTTGAGAGTATCCACAAAGCAATGTCTCAGGTGTGGAC
ACCTGAGAGCATGTTTTAGAAAGCTTTGTACCCTGTCTTGTGGCAGGAAAGAAAGAACAGGGGTTTTACATAAGGAAATAAGTCCTAGGA
AATTAGTCAACGCAAATTGCATTTGCGTTTGTACCTTACCACAGTCTTATATTGTTTTTTAAACTCTGCCATGAAATTTGGAGACATGAC
TGTGAAATTCCTAACTTACTATCTTACAAAGCCAGTAGCTAATTTGTTGCTCTATGTATGATCCTGTTACAAGTCCAGTTTGCAATTCAT
TTGTTTCCTAGAACACAGAAGGGTACCAGTAATACACTAAATTTTCAAGGTGTGTAGAGAAATAATATGGAATTAGCAGCTATGACTCCA
ACAGACAGGATTGTGTGAGCAGCTGAAAGGAGCAAAAAAGAACTCAGTGTAAGAGAAGGCACATACATAGTTAAGAATACTAAAGTATTT
TTAAAAATCAAGGAAGAAATAAATGTTACACAATTTGCATTGGAATAAATAGATCTATTTAGTCCTACAAATCAGGAGTGGTGTAGAGAC
ATCCAAATTTAAAGAAAAAAAAACACAAAACAGAATGTTAAAAAATGTATGCAGATTTATGGATATTATCAATGAGAAGACATAGCATGT
AACTTCTCCTATATCTCTACTGTCCAGCATGTATTGTTCCAAATATGACTCCCTAAAATATATACACTTTGCAGAAGCTCTAGGCCCTCA
CCTCAAACCTTGCCATTGGTTGCCGTATTTCAAGGTCAATATAGTTTCCCTCACTTTACACAATCATTATTCTTCAATAGTGGACCATAT
CCTTCACCAGGTATCCTATTTCTGTTATCTAGAGGTTAGCAGAAAATGAAATGAAGGAATTTCCCTAAGCAGTTGGGAAGAACAAATTGT
ATGCATGTAGGCAAAGATTTTGAAGATACATTTGCAAGAGATATTTGTTTAACCAAAATATTTGGAAAGTAACAAATAAAGACATTTAAA
TTTTCTAAAAATGGACTTGCTCTTCTAGGAAAAGAATACCCCTGGGGCAAAAATATAACTCTAGCTGTATTTCTTCTTGTCACTCTTGAT
TCAACTTGATTATAAATACACCTGTCACTACCAGAACCAAAAAAAAAAAGAAAAAAATCCCAAGCACAAAGCTTATTTTATTTGAAAAAA
ATAAAAAAGAAACTTCAACACTATGGGACACTGGCTCTTTTAGCATGAAATGACTTGAGCTTTTGTAGTGATGATACACATACACACTCA
TCAGTAAAACGATGGTTTCATAAATAACACAATTGATGCAAATCATAAAAATCAATTACAATTATGATTTCATGACAAAATATATTTAAT
TAAGTTTGTTATGAAAAAAATAGAGATATGAATCACTAACAAAATTCCTCCATTTTCAGTGGCTATTCATCATTTATCATCTAGACTCAC
ATTTGTCTCCTTCCTGATAGCAGTTAAGAAAAAATTCTAACCACACAATTTGTATATTGTTTTTCTCCGTATTATGTTAAGCAAATGTTC
ACTGCAGTAAAATGTTTTGGAAATTAGCTTTGTCTTATTTCCAGTTTAGTTCAGAGAATTAATTGGAAACCTGATTTCTTTTACACATAA
ACCTGACAAAAAATGTAGCTTAGAGCAAAGGGTGAATGTTTGCTTAACTCCTGCTTACTTCTCAAGTACATGAAAACTTTAATAGAATAT
GCCAGTATTCACTGAGTTTTTAAAAATATTACCATGTGTAAACATATAATATCCAACTTCATCCAAAAATATGGTTGAGTTTAAGTACTT
TGTTTTTCAGGCTTATTTCAAGTATAATAATTCTTTGATTTTCATTGTTCTGATTTCTGGGTCTTCAATTCATTCGTCACTTTTCCTTTT
TAAGTAAAATAAGCTTTTTTTTTTTTTTTTTTTTTTTTTTGGAGTTGCATTGGGATTTTTCCCAGGAAAAAATATGGCTTTTAGTAATGC
TTTGCAATTGGCTACGCAGATATAAATTAAGATATGTTTATTCTGAGTTCTTATTGGAATAAGTTTCAAAATCAACGAGCTTAAGAATGA
AAACAAAACTTTTGAGAGTCTCACAAAATAGCTTTCTGGTCAATACACCTTACTTGATTTTTAAGCTCGCAGAATAAAGTATAGAAACAA
ATGGAGCTGAAGTTCCATTTGCTAATTCAGAGACTTTTGTGCTTCCGCAAATTGGAGGGCAGCAAGCCATCCTATTCTCATAGTAATCGT
TTTGGCTTTGAAATTTACATACAATTTAATAGCACATTTTTAGCCATTATGGATTGGCGCAATAAAGAGATATCAATGTAATGCAATGTG
ATGCTTTATGGGCCTCATTCTAATTCAGAAAGCTTGTTTAAAAGAACTAAGACTCTTCTGTTTAATAAAATAGCAACAATCTAATATCTA
GATTGGTAGTCCTGCGGTGCCACTAGTGGGAGATGAGAGTATTAAGACAAGAGTAAGGACAAGGAAAGACTTAAAGGTTGCATATTGAAA
AGTTTGGAATTCCTAATTTGGGAGCACTGATTTCTTGGTGAAGAAGTAAGTATGACTACGTTGCCAGTAATTTTTTAAAAACATAGACCC
AGAAATAGCAAATCGATTTCACCCTCATACCTTAGTCTACAAGGCCTTGCTCTTGAGAAGGTTTTCCATGATATTGCTTAATTTCATCTG
CACAAGATGAGACACAAACATAAAAATTCCCTGCTCATTTTAATACCATAAAAGGCTGAGGTTATTTCTCTGTCATAAAATTGTAAATAG
CATTTTTTAAGTCAAAATTACATTTAAAACAGTGGATTGTTCTACAAATATATATGTGTATATATACATATGCTTCTGAAATAAGGATAT
ATTATATGAGTTTTTATTTGATTTGTGGTCTTTAGTCATAGGTAATCAAAAATAAAGAGATTTGAATGCAAAACTTTATACATTAATGTA
CATTTCTAATGATGGTACAAATTGCCACTTTATAATAAAAAAGAAACAGGTGGGAATAATAATCAAAGCACGTGTTCCTTCAGTACTTTG
GTGATTTTTAATCCCCCTTGTGATGCACAGGAAATTATTTTTTAGTTACAAAAAGTTATCTTAGAAATCTATACTTCCCAATACAGATTT
CATGTTAAGTCATATCAAATTGAGAATTTGTGGTGAAAGAATAGGAAAAGGATGCTAGATGCTGATCTTTCTTTTTCAGGATTTTTCCTG
GAGCCCAAGTTAAAAATTCAATACTTAAATCTAAGTTAAGTGAAAATTAATAATGTTCAGAATGATGTATTGAGCTTTAGTAACAGACGG
AAGCAAAAAAAAATAAGAATATTTAACATTATGATAATAGCCTTAAAATAATGTAATAAAAATTGCATCATTAAATGTTCTATTAGTTGG
AAAGAATGAGCTGATGTTTCTTTGTCTTTGCTCCAAGTACAATTTAAAGACAGTGACATTCATTTTACTTAAAATTGTTCAAAAAGTCCA
AAACATACTCCCATGGCTAGAATTGGTATTAGCTCCAATACAAGGTTAAATGTTACAATCTTAAGAAATTATTGACACTGAAATGTTTAG

>51953_51953_3_MB21D2-FGF12_MB21D2_chr3_192635419_ENST00000392452_FGF12_chr3_191888445_ENST00000445105_length(amino acids)=151AA_BP=
MQSSSSRSSHAQSARSGGLPAQTPARQPAHEPGPKPGSLRGEEAQGGGVGGGGGCRAAAELLLGAFCMKMAAPTANKAASLGCNNKPAFP

--------------------------------------------------------------
>51953_51953_4_MB21D2-FGF12_MB21D2_chr3_192635419_ENST00000392452_FGF12_chr3_191888445_ENST00000450716_length(transcript)=881nt_BP=532nt
AGTTGGCTCTACGACCGCCGTTGCCGCTGCCAGAGAGGGCCAGGGCAGGGCAGGGACGCGCAGCATCGGGGCGGGCGTGGGGCCGGAGAA
AAGGGTGTCGGGGCCACACACGCACCCTCGCTGCAGTCCAGCTCCTCCCGAAGCTCGCACGCCCAGAGCGCACGGAGCGGGGGACTGCCC
GCCCAGACGCCCGCCCGCCAACCCGCCCACGAGCCGGGGCCAAAGCCTGGGAGCCTGCGAGGGGAGGAGGCCCAGGGGGGCGGGGTGGGG
GGCGGGGGTGGGTGCCGCGCTGCCGCGGAGCTGCTACTCGGCGCGTTTTGCATGAAGATGGCGGCTCCCACCGCCAACAAGGCAGCCTCC
CTGGGCTGTAACAACAAGCCTGCGTTCCCGGAGCTGGATTTCAGGTCGGGAGCTCGGGTGGAGGAATTGAACAAACTCATCCAAGAATTT
ACGAAGCACGACCAGCGGGAATACGACGACCAGAGAGCGCTGGAGATTCACACAGCCAAGGATTTCATCTTTTCCATGCTGGGATGTTTT
CACTCCAGAATGCAAATTCAAGGAATCTGTGTTTGAAAACTACTATGTGATCTATTCTTCCACACTGTACCGCCAGCAAGAATCAGGCCG
AGCTTGGTTTCTGGGACTCAATAAAGAAGGTCAAATTATGAAGGGGAACAGAGTGAAGAAAACCAAGCCCTCATCACATTTTGTACCGAA
ACCTATTGAAGTGTGTATGTACAGAGAACCATCGCTACATGAAATTGGAGAAAAACAAGGGCGTTCAAGGAAAAGTTCTGGAACACCAAC

>51953_51953_4_MB21D2-FGF12_MB21D2_chr3_192635419_ENST00000392452_FGF12_chr3_191888445_ENST00000450716_length(amino acids)=151AA_BP=
MQSSSSRSSHAQSARSGGLPAQTPARQPAHEPGPKPGSLRGEEAQGGGVGGGGGCRAAAELLLGAFCMKMAAPTANKAASLGCNNKPAFP

--------------------------------------------------------------
>51953_51953_5_MB21D2-FGF12_MB21D2_chr3_192635419_ENST00000392452_FGF12_chr3_191888445_ENST00000454309_length(transcript)=2350nt_BP=532nt
AGTTGGCTCTACGACCGCCGTTGCCGCTGCCAGAGAGGGCCAGGGCAGGGCAGGGACGCGCAGCATCGGGGCGGGCGTGGGGCCGGAGAA
AAGGGTGTCGGGGCCACACACGCACCCTCGCTGCAGTCCAGCTCCTCCCGAAGCTCGCACGCCCAGAGCGCACGGAGCGGGGGACTGCCC
GCCCAGACGCCCGCCCGCCAACCCGCCCACGAGCCGGGGCCAAAGCCTGGGAGCCTGCGAGGGGAGGAGGCCCAGGGGGGCGGGGTGGGG
GGCGGGGGTGGGTGCCGCGCTGCCGCGGAGCTGCTACTCGGCGCGTTTTGCATGAAGATGGCGGCTCCCACCGCCAACAAGGCAGCCTCC
CTGGGCTGTAACAACAAGCCTGCGTTCCCGGAGCTGGATTTCAGGTCGGGAGCTCGGGTGGAGGAATTGAACAAACTCATCCAAGAATTT
ACGAAGCACGACCAGCGGGAATACGACGACCAGAGAGCGCTGGAGATTCACACAGCCAAGGATTTCATCTTTTCCATGCTGGGATGTTTT
CACTCCAGAATGCAAATTCAAGGAATCTGTGTTTGAAAACTACTATGTGATCTATTCTTCCACACTGTACCGCCAGCAAGAATCAGGCCG
AGCTTGGTTTCTGGGACTCAATAAAGAAGGTCAAATTATGAAGGGGAACAGAGTGAAGAAAACCAAGCCCTCATCACATTTTGTACCGAA
ACCTATTGAAGTGTGTATGTACAGAGAACCATCGCTACATGAAATTGGAGAAAAACAAGGGCGTTCAAGGAAAAGTTCTGGAACACCAAC
CATGAATGGAGGCAAAGTTGTGAATCAAGATTCAACATAGCTGAGAACTCTCCCCTTCTTCCCTCTCTCATCCCTTCCCCTTCCCTTCCT
TCCCATTTACCCATTTCCTTCCAGTAAATCCACCCAAGGAGAGGAAAATAAAATGACAACGCAAGACCTAGTGGCTAAGATTCTGCACTC
AAAATCTTCCTTTGTGTAGGACAAGAAAATTGAACCAAAGCTTGCTTGTTGCAATGTGGTAGAAAATTCACGTGCACAAAGATTAGCACA
CTTAAAAGCAAAGGAAAAAATAAATCAGAACTCCATAAATATTAAATTAAACTGTATTGTTATTAGTAGAAGGCTAATTGTAATGAAGAC
ATTAATAAAGATGAAATAAACTTATTACTTTAAAGGAAAGGATTTGGAGAATTGAACTCACAAACTGATGTTATATACTCAATAGCTTAA
ACTCATGATAATGCTGCGATGTGTGGTTTTGCTTGATTTTGTATTTTATTTGGGCATCTGGAATTGACACACCATTACATTCTGTTTGCA
GGATTTTTTTTGTAACCATGAAATTGAACATTTCCAAATTATAAACTATGTTAATACCTATAAAATATATAGCCAGGAACCATTTATCAT
CAAGAAAAGTGTAAGAAATTATTTTTGAGATGTAATTTAAGATTGTTTTATGTAAAAGGAAAATCTTGTATGGCATCGAATAGCCTTAAT
GAGTTTAATTCTTTCACAAAAATGATTTCAAATTATCCTAGAGTATAACATTTTTATCAAAGATATTATTTCCGGAGTTCTTCTTTCTTT
CTTTTTTTTTTTTTTTTAGTAATTTAGCAAAAACATTACTGTTCTAATGCTGAAGTGACTTTTGCCAGTGCCATGTCCAGGTGGTGAGGT
ATAAGTTACTTGCTCTTAGCATTTGGTCTGATTTTTTTGCTTTGTGGACACCTTTGAGAGTATCCACAAAGCAATGTCTCAGGTGTGGAC
ACCTGAGAGCATGTTTTAGAAAGCTTTGTACCCTGTCTTGTGGCAGGAAAGAAAGAACAGGGGTTTTACATAAGGAAATAAGTCCTAGGA
AATTAGTCAACGCAAATTGCATTTGCGTTTGTACCTTACCACAGTCTTATATTGTTTTTTAAACTCTGCCATGAAATTTGGAGACATGAC
TGTGAAATTCCTAACTTACTATCTTACAAAGCCAGTAGCTAATTTGTTGCTCTATGTATGATCCTGTTACAAGTCCAGTTTGCAATTCAT
TTGTTTCCTAGAACACAGAAGGGTACCAGTAATACACTAAATTTTCAAGGTGTGTAGAGAAATAATATGGAATTAGCAGCTATGACTCCA
ACAGACAGGATTGTGTGAGCAGCTGAAAGGAGCAAAAAAGAACTCAGTGTAAGAGAAGGCACATACATAGTTAAGAATACTAAAGTATTT
TTAAAAATCAAGGAAGAAATAAATGTTACACAATTTGCATTGGAATAAATAGATCTATTTAGTCCTACAAATCAGGAGTGGTGTAGAGAC

>51953_51953_5_MB21D2-FGF12_MB21D2_chr3_192635419_ENST00000392452_FGF12_chr3_191888445_ENST00000454309_length(amino acids)=151AA_BP=
MQSSSSRSSHAQSARSGGLPAQTPARQPAHEPGPKPGSLRGEEAQGGGVGGGGGCRAAAELLLGAFCMKMAAPTANKAASLGCNNKPAFP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MB21D2-FGF12

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MB21D2-FGF12

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MB21D2-FGF12

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source