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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MBD2-DOCK2 (FusionGDB2 ID:51961)

Fusion Gene Summary for MBD2-DOCK2

check button Fusion gene summary
Fusion gene informationFusion gene name: MBD2-DOCK2
Fusion gene ID: 51961
HgeneTgene
Gene symbol

MBD2

DOCK2

Gene ID

64174

1794

Gene namedipeptidase 2dedicator of cytokinesis 2
SynonymsMBD2IMD40
Cytomap

16q22.1

5q35.1

Type of geneprotein-codingprotein-coding
Descriptiondipeptidase 2dedicator of cytokinesis protein 2dedicator of cyto-kinesis 2
Modification date2020031320200313
UniProtAcc.

Q92608

Ensembl transtripts involved in fusion geneENST00000256429, ENST00000398398, 
ENST00000579025, ENST00000583046, 
ENST00000523351, ENST00000256935, 
ENST00000520908, ENST00000540750, 
Fusion gene scores* DoF score8 X 10 X 4=32013 X 12 X 8=1248
# samples 1015
** MAII scorelog2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1248*10)=-3.05658352836637
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBD2 [Title/Abstract] AND DOCK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMBD2(51715244)-DOCK2(169502951), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MBD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DOCK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A1AY-01AMBD2chr18

51714083

-DOCK2chr5

169502950

+
ChimerDB4BRCATCGA-AR-A1AY-01AMBD2chr18

51715243

-DOCK2chr5

169502950

+
ChimerDB4BRCATCGA-AR-A1AY-01AMBD2chr18

51715244

-DOCK2chr5

169502951

+
ChimerDB4BRCATCGA-AR-A1AYMBD2chr18

51715243

-DOCK2chr5

169502950

+


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Fusion Gene ORF analysis for MBD2-DOCK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000256429ENST00000523351MBD2chr18

51715244

-DOCK2chr5

169502951

+
5CDS-3UTRENST00000256429ENST00000523351MBD2chr18

51715243

-DOCK2chr5

169502950

+
In-frameENST00000256429ENST00000256935MBD2chr18

51715244

-DOCK2chr5

169502951

+
In-frameENST00000256429ENST00000256935MBD2chr18

51715243

-DOCK2chr5

169502950

+
In-frameENST00000256429ENST00000520908MBD2chr18

51715244

-DOCK2chr5

169502951

+
In-frameENST00000256429ENST00000520908MBD2chr18

51715243

-DOCK2chr5

169502950

+
In-frameENST00000256429ENST00000540750MBD2chr18

51715244

-DOCK2chr5

169502951

+
In-frameENST00000256429ENST00000540750MBD2chr18

51715243

-DOCK2chr5

169502950

+
intron-3CDSENST00000256429ENST00000256935MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3CDSENST00000256429ENST00000520908MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3CDSENST00000256429ENST00000540750MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3CDSENST00000398398ENST00000256935MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3CDSENST00000398398ENST00000256935MBD2chr18

51715244

-DOCK2chr5

169502951

+
intron-3CDSENST00000398398ENST00000256935MBD2chr18

51715243

-DOCK2chr5

169502950

+
intron-3CDSENST00000398398ENST00000520908MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3CDSENST00000398398ENST00000520908MBD2chr18

51715244

-DOCK2chr5

169502951

+
intron-3CDSENST00000398398ENST00000520908MBD2chr18

51715243

-DOCK2chr5

169502950

+
intron-3CDSENST00000398398ENST00000540750MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3CDSENST00000398398ENST00000540750MBD2chr18

51715244

-DOCK2chr5

169502951

+
intron-3CDSENST00000398398ENST00000540750MBD2chr18

51715243

-DOCK2chr5

169502950

+
intron-3CDSENST00000579025ENST00000256935MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3CDSENST00000579025ENST00000256935MBD2chr18

51715244

-DOCK2chr5

169502951

+
intron-3CDSENST00000579025ENST00000256935MBD2chr18

51715243

-DOCK2chr5

169502950

+
intron-3CDSENST00000579025ENST00000520908MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3CDSENST00000579025ENST00000520908MBD2chr18

51715244

-DOCK2chr5

169502951

+
intron-3CDSENST00000579025ENST00000520908MBD2chr18

51715243

-DOCK2chr5

169502950

+
intron-3CDSENST00000579025ENST00000540750MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3CDSENST00000579025ENST00000540750MBD2chr18

51715244

-DOCK2chr5

169502951

+
intron-3CDSENST00000579025ENST00000540750MBD2chr18

51715243

-DOCK2chr5

169502950

+
intron-3CDSENST00000583046ENST00000256935MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3CDSENST00000583046ENST00000256935MBD2chr18

51715244

-DOCK2chr5

169502951

+
intron-3CDSENST00000583046ENST00000256935MBD2chr18

51715243

-DOCK2chr5

169502950

+
intron-3CDSENST00000583046ENST00000520908MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3CDSENST00000583046ENST00000520908MBD2chr18

51715244

-DOCK2chr5

169502951

+
intron-3CDSENST00000583046ENST00000520908MBD2chr18

51715243

-DOCK2chr5

169502950

+
intron-3CDSENST00000583046ENST00000540750MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3CDSENST00000583046ENST00000540750MBD2chr18

51715244

-DOCK2chr5

169502951

+
intron-3CDSENST00000583046ENST00000540750MBD2chr18

51715243

-DOCK2chr5

169502950

+
intron-3UTRENST00000256429ENST00000523351MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3UTRENST00000398398ENST00000523351MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3UTRENST00000398398ENST00000523351MBD2chr18

51715244

-DOCK2chr5

169502951

+
intron-3UTRENST00000398398ENST00000523351MBD2chr18

51715243

-DOCK2chr5

169502950

+
intron-3UTRENST00000579025ENST00000523351MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3UTRENST00000579025ENST00000523351MBD2chr18

51715244

-DOCK2chr5

169502951

+
intron-3UTRENST00000579025ENST00000523351MBD2chr18

51715243

-DOCK2chr5

169502950

+
intron-3UTRENST00000583046ENST00000523351MBD2chr18

51714083

-DOCK2chr5

169502950

+
intron-3UTRENST00000583046ENST00000523351MBD2chr18

51715244

-DOCK2chr5

169502951

+
intron-3UTRENST00000583046ENST00000523351MBD2chr18

51715243

-DOCK2chr5

169502950

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256429MBD2chr1851715244-ENST00000256935DOCK2chr5169502951+235810691511833560
ENST00000256429MBD2chr1851715244-ENST00000540750DOCK2chr5169502951+235310691511833560
ENST00000256429MBD2chr1851715244-ENST00000520908DOCK2chr5169502951+235510691511833560
ENST00000256429MBD2chr1851715243-ENST00000256935DOCK2chr5169502950+235810691511833560
ENST00000256429MBD2chr1851715243-ENST00000540750DOCK2chr5169502950+235310691511833560
ENST00000256429MBD2chr1851715243-ENST00000520908DOCK2chr5169502950+235510691511833560

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256429ENST00000256935MBD2chr1851715244-DOCK2chr5169502951+0.040586290.9594137
ENST00000256429ENST00000540750MBD2chr1851715244-DOCK2chr5169502951+0.0411463640.95885366
ENST00000256429ENST00000520908MBD2chr1851715244-DOCK2chr5169502951+0.041332540.9586675
ENST00000256429ENST00000256935MBD2chr1851715243-DOCK2chr5169502950+0.040586290.9594137
ENST00000256429ENST00000540750MBD2chr1851715243-DOCK2chr5169502950+0.0411463640.95885366
ENST00000256429ENST00000520908MBD2chr1851715243-DOCK2chr5169502950+0.041332540.9586675

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Fusion Genomic Features for MBD2-DOCK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MBD2-DOCK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:51715244/chr5:169502951)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DOCK2

Q92608

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMBD2chr18:51715243chr5:169502950ENST00000256429-3750_962801015.6666666666666Compositional biasNote=Arg-rich
HgeneMBD2chr18:51715243chr5:169502950ENST00000256429-376_1402801015.6666666666666Compositional biasNote=Gly-rich
HgeneMBD2chr18:51715244chr5:169502951ENST00000256429-3750_962801015.6666666666666Compositional biasNote=Arg-rich
HgeneMBD2chr18:51715244chr5:169502951ENST00000256429-376_1402801015.6666666666666Compositional biasNote=Gly-rich
HgeneMBD2chr18:51715243chr5:169502950ENST00000256429-37145_2132801015.6666666666666DomainMBD
HgeneMBD2chr18:51715244chr5:169502951ENST00000256429-37145_2132801015.6666666666666DomainMBD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMBD2chr18:51715243chr5:169502950ENST00000583046-1350_960303.0Compositional biasNote=Arg-rich
HgeneMBD2chr18:51715243chr5:169502950ENST00000583046-136_1400303.0Compositional biasNote=Gly-rich
HgeneMBD2chr18:51715244chr5:169502951ENST00000583046-1350_960303.0Compositional biasNote=Arg-rich
HgeneMBD2chr18:51715244chr5:169502951ENST00000583046-136_1400303.0Compositional biasNote=Gly-rich
HgeneMBD2chr18:51715243chr5:169502950ENST00000583046-13145_2130303.0DomainMBD
HgeneMBD2chr18:51715244chr5:169502951ENST00000583046-13145_2130303.0DomainMBD
TgeneDOCK2chr18:51715243chr5:169502950ENST0000025693545521211_162215761831.0DomainDOCKER
TgeneDOCK2chr18:51715243chr5:169502950ENST000002569354552423_60715761831.0DomainC2 DOCK-type
TgeneDOCK2chr18:51715243chr5:169502950ENST0000025693545528_6915761831.0DomainSH3
TgeneDOCK2chr18:51715244chr5:169502951ENST0000025693545521211_162215761831.0DomainDOCKER
TgeneDOCK2chr18:51715244chr5:169502951ENST000002569354552423_60715761831.0DomainC2 DOCK-type
TgeneDOCK2chr18:51715244chr5:169502951ENST0000025693545528_6915761831.0DomainSH3


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Fusion Gene Sequence for MBD2-DOCK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51961_51961_1_MBD2-DOCK2_MBD2_chr18_51715243_ENST00000256429_DOCK2_chr5_169502950_ENST00000256935_length(transcript)=2358nt_BP=1069nt
GGGGGCGTGGCCCCGAGAAGGCGGAGACAAGATGGCCGCCCATAGCGCTTGGAGGACCTAAGAGGCGGTGGCCGGGGCCACGCCCCGGGC
AGGAGGGCCGCTCTGTGCGCGCCCGCTCTATGATGCTTGCGCGCGTCCCCCGCGCGCCGCGCTGCGGGCGGGGCGGGTCTCCGGGATTCC
AAGGGCTCGGTTACGGAAGAAGCGCAGCGCCGGCTGGGGAGGGGGCTGGATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCA
GGAGGAGGGGGAGAGTGCGGCGGGCGGCAGCGGCGCTGGCGGCGACTCCGCCATAGAGCAGGGGGGCCAGGGCAGCGCGCTCGCCCCGTC
CCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGCCGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTG
TGGCCGTGGCCGGGGCCGGGGCCGTGGCCGGGGACGGGGACGGGGCCGGGGCCGGGGCCGCGGCCGTCCCCCGAGTGGCGGCAGCGGCCT
TGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGCGCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGC
GGGGCCGGGGCCCAGGGGACCCCGGGCCACGGAGAGCGGGAAGAGGATGGATTGCCCGGCCCTCCCCCCCGGATGGAAGAAGGAGGAAGT
GATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTCAGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGC
AAGGTACCTGGGAAATACTGTTGATCTCAGCAGTTTTGACTTCAGAACTGGAAAGATGATGCCTAGTAAATTACAGAAGAACAAACAGAG
ACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAATACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACA
ACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTCAGATCCCCTTCTT
GGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAA
AATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATA
CAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATT
AGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAA
GAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCAT
GAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTAC
CATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACT
CTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAA
ACAGATCCCAGACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGTTTCTGGAAGAGG
AAAGCCATGCGTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGAGAGGCCAATCAG
GTCCCAGAGCTTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGATTCCTGAACTCA
AGGTACCAGCAAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAGGTGTAAGAAACT
GTTTTTATCTCATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAGATTAACAGTTTT
GTACTTTACATTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGACAATAAAAAATG

>51961_51961_1_MBD2-DOCK2_MBD2_chr18_51715243_ENST00000256429_DOCK2_chr5_169502950_ENST00000256935_length(amino acids)=560AA_BP=102
MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW
KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA
LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP
IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV
GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL
KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM

--------------------------------------------------------------
>51961_51961_2_MBD2-DOCK2_MBD2_chr18_51715243_ENST00000256429_DOCK2_chr5_169502950_ENST00000520908_length(transcript)=2355nt_BP=1069nt
GGGGGCGTGGCCCCGAGAAGGCGGAGACAAGATGGCCGCCCATAGCGCTTGGAGGACCTAAGAGGCGGTGGCCGGGGCCACGCCCCGGGC
AGGAGGGCCGCTCTGTGCGCGCCCGCTCTATGATGCTTGCGCGCGTCCCCCGCGCGCCGCGCTGCGGGCGGGGCGGGTCTCCGGGATTCC
AAGGGCTCGGTTACGGAAGAAGCGCAGCGCCGGCTGGGGAGGGGGCTGGATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCA
GGAGGAGGGGGAGAGTGCGGCGGGCGGCAGCGGCGCTGGCGGCGACTCCGCCATAGAGCAGGGGGGCCAGGGCAGCGCGCTCGCCCCGTC
CCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGCCGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTG
TGGCCGTGGCCGGGGCCGGGGCCGTGGCCGGGGACGGGGACGGGGCCGGGGCCGGGGCCGCGGCCGTCCCCCGAGTGGCGGCAGCGGCCT
TGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGCGCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGC
GGGGCCGGGGCCCAGGGGACCCCGGGCCACGGAGAGCGGGAAGAGGATGGATTGCCCGGCCCTCCCCCCCGGATGGAAGAAGGAGGAAGT
GATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTCAGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGC
AAGGTACCTGGGAAATACTGTTGATCTCAGCAGTTTTGACTTCAGAACTGGAAAGATGATGCCTAGTAAATTACAGAAGAACAAACAGAG
ACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAATACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACA
ACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTCAGATCCCCTTCTT
GGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAA
AATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATA
CAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATT
AGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAA
GAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCAT
GAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTAC
CATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACT
CTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAA
ACAGATCCCAGACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGTTTCTGGAAGAGG
AAAGCCATGCGTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGAGAGGCCAATCAG
GTCCCAGAGCTTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGATTCCTGAACTCA
AGGTACCAGCAAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAGGTGTAAGAAACT
GTTTTTATCTCATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAGATTAACAGTTTT
GTACTTTACATTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGACAATAAAAAATG

>51961_51961_2_MBD2-DOCK2_MBD2_chr18_51715243_ENST00000256429_DOCK2_chr5_169502950_ENST00000520908_length(amino acids)=560AA_BP=102
MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW
KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA
LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP
IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV
GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL
KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM

--------------------------------------------------------------
>51961_51961_3_MBD2-DOCK2_MBD2_chr18_51715243_ENST00000256429_DOCK2_chr5_169502950_ENST00000540750_length(transcript)=2353nt_BP=1069nt
GGGGGCGTGGCCCCGAGAAGGCGGAGACAAGATGGCCGCCCATAGCGCTTGGAGGACCTAAGAGGCGGTGGCCGGGGCCACGCCCCGGGC
AGGAGGGCCGCTCTGTGCGCGCCCGCTCTATGATGCTTGCGCGCGTCCCCCGCGCGCCGCGCTGCGGGCGGGGCGGGTCTCCGGGATTCC
AAGGGCTCGGTTACGGAAGAAGCGCAGCGCCGGCTGGGGAGGGGGCTGGATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCA
GGAGGAGGGGGAGAGTGCGGCGGGCGGCAGCGGCGCTGGCGGCGACTCCGCCATAGAGCAGGGGGGCCAGGGCAGCGCGCTCGCCCCGTC
CCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGCCGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTG
TGGCCGTGGCCGGGGCCGGGGCCGTGGCCGGGGACGGGGACGGGGCCGGGGCCGGGGCCGCGGCCGTCCCCCGAGTGGCGGCAGCGGCCT
TGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGCGCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGC
GGGGCCGGGGCCCAGGGGACCCCGGGCCACGGAGAGCGGGAAGAGGATGGATTGCCCGGCCCTCCCCCCCGGATGGAAGAAGGAGGAAGT
GATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTCAGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGC
AAGGTACCTGGGAAATACTGTTGATCTCAGCAGTTTTGACTTCAGAACTGGAAAGATGATGCCTAGTAAATTACAGAAGAACAAACAGAG
ACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAATACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACA
ACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTCAGATCCCCTTCTT
GGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAA
AATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATA
CAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATT
AGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAA
GAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCAT
GAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTAC
CATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACT
CTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAA
ACAGATCCCAGACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGTTTCTGGAAGAGG
AAAGCCATGCGTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGAGAGGCCAATCAG
GTCCCAGAGCTTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGATTCCTGAACTCA
AGGTACCAGCAAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAGGTGTAAGAAACT
GTTTTTATCTCATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAGATTAACAGTTTT
GTACTTTACATTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGACAATAAAAAATG

>51961_51961_3_MBD2-DOCK2_MBD2_chr18_51715243_ENST00000256429_DOCK2_chr5_169502950_ENST00000540750_length(amino acids)=560AA_BP=102
MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW
KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA
LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP
IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV
GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL
KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM

--------------------------------------------------------------
>51961_51961_4_MBD2-DOCK2_MBD2_chr18_51715244_ENST00000256429_DOCK2_chr5_169502951_ENST00000256935_length(transcript)=2358nt_BP=1069nt
GGGGGCGTGGCCCCGAGAAGGCGGAGACAAGATGGCCGCCCATAGCGCTTGGAGGACCTAAGAGGCGGTGGCCGGGGCCACGCCCCGGGC
AGGAGGGCCGCTCTGTGCGCGCCCGCTCTATGATGCTTGCGCGCGTCCCCCGCGCGCCGCGCTGCGGGCGGGGCGGGTCTCCGGGATTCC
AAGGGCTCGGTTACGGAAGAAGCGCAGCGCCGGCTGGGGAGGGGGCTGGATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCA
GGAGGAGGGGGAGAGTGCGGCGGGCGGCAGCGGCGCTGGCGGCGACTCCGCCATAGAGCAGGGGGGCCAGGGCAGCGCGCTCGCCCCGTC
CCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGCCGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTG
TGGCCGTGGCCGGGGCCGGGGCCGTGGCCGGGGACGGGGACGGGGCCGGGGCCGGGGCCGCGGCCGTCCCCCGAGTGGCGGCAGCGGCCT
TGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGCGCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGC
GGGGCCGGGGCCCAGGGGACCCCGGGCCACGGAGAGCGGGAAGAGGATGGATTGCCCGGCCCTCCCCCCCGGATGGAAGAAGGAGGAAGT
GATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTCAGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGC
AAGGTACCTGGGAAATACTGTTGATCTCAGCAGTTTTGACTTCAGAACTGGAAAGATGATGCCTAGTAAATTACAGAAGAACAAACAGAG
ACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAATACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACA
ACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTCAGATCCCCTTCTT
GGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAA
AATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATA
CAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATT
AGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAA
GAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCAT
GAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTAC
CATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACT
CTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAA
ACAGATCCCAGACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGTTTCTGGAAGAGG
AAAGCCATGCGTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGAGAGGCCAATCAG
GTCCCAGAGCTTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGATTCCTGAACTCA
AGGTACCAGCAAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAGGTGTAAGAAACT
GTTTTTATCTCATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAGATTAACAGTTTT
GTACTTTACATTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGACAATAAAAAATG

>51961_51961_4_MBD2-DOCK2_MBD2_chr18_51715244_ENST00000256429_DOCK2_chr5_169502951_ENST00000256935_length(amino acids)=560AA_BP=102
MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW
KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA
LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP
IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV
GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL
KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM

--------------------------------------------------------------
>51961_51961_5_MBD2-DOCK2_MBD2_chr18_51715244_ENST00000256429_DOCK2_chr5_169502951_ENST00000520908_length(transcript)=2355nt_BP=1069nt
GGGGGCGTGGCCCCGAGAAGGCGGAGACAAGATGGCCGCCCATAGCGCTTGGAGGACCTAAGAGGCGGTGGCCGGGGCCACGCCCCGGGC
AGGAGGGCCGCTCTGTGCGCGCCCGCTCTATGATGCTTGCGCGCGTCCCCCGCGCGCCGCGCTGCGGGCGGGGCGGGTCTCCGGGATTCC
AAGGGCTCGGTTACGGAAGAAGCGCAGCGCCGGCTGGGGAGGGGGCTGGATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCA
GGAGGAGGGGGAGAGTGCGGCGGGCGGCAGCGGCGCTGGCGGCGACTCCGCCATAGAGCAGGGGGGCCAGGGCAGCGCGCTCGCCCCGTC
CCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGCCGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTG
TGGCCGTGGCCGGGGCCGGGGCCGTGGCCGGGGACGGGGACGGGGCCGGGGCCGGGGCCGCGGCCGTCCCCCGAGTGGCGGCAGCGGCCT
TGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGCGCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGC
GGGGCCGGGGCCCAGGGGACCCCGGGCCACGGAGAGCGGGAAGAGGATGGATTGCCCGGCCCTCCCCCCCGGATGGAAGAAGGAGGAAGT
GATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTCAGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGC
AAGGTACCTGGGAAATACTGTTGATCTCAGCAGTTTTGACTTCAGAACTGGAAAGATGATGCCTAGTAAATTACAGAAGAACAAACAGAG
ACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAATACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACA
ACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTCAGATCCCCTTCTT
GGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAA
AATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATA
CAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATT
AGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAA
GAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCAT
GAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTAC
CATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACT
CTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAA
ACAGATCCCAGACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGTTTCTGGAAGAGG
AAAGCCATGCGTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGAGAGGCCAATCAG
GTCCCAGAGCTTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGATTCCTGAACTCA
AGGTACCAGCAAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAGGTGTAAGAAACT
GTTTTTATCTCATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAGATTAACAGTTTT
GTACTTTACATTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGACAATAAAAAATG

>51961_51961_5_MBD2-DOCK2_MBD2_chr18_51715244_ENST00000256429_DOCK2_chr5_169502951_ENST00000520908_length(amino acids)=560AA_BP=102
MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW
KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA
LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP
IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV
GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL
KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM

--------------------------------------------------------------
>51961_51961_6_MBD2-DOCK2_MBD2_chr18_51715244_ENST00000256429_DOCK2_chr5_169502951_ENST00000540750_length(transcript)=2353nt_BP=1069nt
GGGGGCGTGGCCCCGAGAAGGCGGAGACAAGATGGCCGCCCATAGCGCTTGGAGGACCTAAGAGGCGGTGGCCGGGGCCACGCCCCGGGC
AGGAGGGCCGCTCTGTGCGCGCCCGCTCTATGATGCTTGCGCGCGTCCCCCGCGCGCCGCGCTGCGGGCGGGGCGGGTCTCCGGGATTCC
AAGGGCTCGGTTACGGAAGAAGCGCAGCGCCGGCTGGGGAGGGGGCTGGATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCA
GGAGGAGGGGGAGAGTGCGGCGGGCGGCAGCGGCGCTGGCGGCGACTCCGCCATAGAGCAGGGGGGCCAGGGCAGCGCGCTCGCCCCGTC
CCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGCCGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTG
TGGCCGTGGCCGGGGCCGGGGCCGTGGCCGGGGACGGGGACGGGGCCGGGGCCGGGGCCGCGGCCGTCCCCCGAGTGGCGGCAGCGGCCT
TGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGCGCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGC
GGGGCCGGGGCCCAGGGGACCCCGGGCCACGGAGAGCGGGAAGAGGATGGATTGCCCGGCCCTCCCCCCCGGATGGAAGAAGGAGGAAGT
GATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTCAGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGC
AAGGTACCTGGGAAATACTGTTGATCTCAGCAGTTTTGACTTCAGAACTGGAAAGATGATGCCTAGTAAATTACAGAAGAACAAACAGAG
ACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAATACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACA
ACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTCAGATCCCCTTCTT
GGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAA
AATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATA
CAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATT
AGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAA
GAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCAT
GAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTAC
CATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACT
CTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAA
ACAGATCCCAGACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGTTTCTGGAAGAGG
AAAGCCATGCGTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGAGAGGCCAATCAG
GTCCCAGAGCTTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGATTCCTGAACTCA
AGGTACCAGCAAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAGGTGTAAGAAACT
GTTTTTATCTCATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAGATTAACAGTTTT
GTACTTTACATTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGACAATAAAAAATG

>51961_51961_6_MBD2-DOCK2_MBD2_chr18_51715244_ENST00000256429_DOCK2_chr5_169502951_ENST00000540750_length(amino acids)=560AA_BP=102
MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW
KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA
LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP
IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV
GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL
KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MBD2-DOCK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneDOCK2chr18:51715243chr5:169502950ENST000002569354552939_14761576.01831.0CRKL
TgeneDOCK2chr18:51715244chr5:169502951ENST000002569354552939_14761576.01831.0CRKL


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MBD2-DOCK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MBD2-DOCK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource