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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MBNL1-ABCC5 (FusionGDB2 ID:51998)

Fusion Gene Summary for MBNL1-ABCC5

check button Fusion gene summary
Fusion gene informationFusion gene name: MBNL1-ABCC5
Fusion gene ID: 51998
HgeneTgene
Gene symbol

MBNL1

ABCC5

Gene ID

4154

10057

Gene namemuscleblind like splicing regulator 1ATP binding cassette subfamily C member 5
SynonymsEXP|MBNLABC33|EST277145|MOAT-C|MOATC|MRP5|SMRP|pABC11
Cytomap

3q25.1-q25.2

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionmuscleblind-like protein 1muscleblind-liketriplet-expansion RNA-binding proteinmultidrug resistance-associated protein 5ATP-binding cassette, sub-family C (CFTR/MRP), member 5canalicular multispecific organic anion transporter Cmulti-specific organic anion transporter C
Modification date2020032720200313
UniProtAcc

Q9NR56

O15440

Ensembl transtripts involved in fusion geneENST00000461436, ENST00000282486, 
ENST00000282488, ENST00000324196, 
ENST00000324210, ENST00000355460, 
ENST00000357472, ENST00000463374, 
ENST00000485509, ENST00000485910, 
ENST00000492948, ENST00000498502, 
ENST00000545754, ENST00000493459, 
ENST00000334444, ENST00000382494, 
ENST00000392579, ENST00000427120, 
ENST00000446941, ENST00000265586, 
ENST00000492216, 
Fusion gene scores* DoF score19 X 10 X 10=19006 X 7 X 6=252
# samples 219
** MAII scorelog2(21/1900*10)=-3.17753818555219
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBNL1 [Title/Abstract] AND ABCC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMBNL1(152018156)-ABCC5(183732235), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMBNL1

GO:0008380

RNA splicing

18335541

HgeneMBNL1

GO:0043484

regulation of RNA splicing

15257297|16946708

TgeneABCC5

GO:0042908

xenobiotic transport

10840050

TgeneABCC5

GO:0140115

export across plasma membrane

10840050


check buttonFusion gene breakpoints across MBNL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABCC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PE-01AMBNL1chr3

151986881

+ABCC5chr3

183732235

-
ChimerDB4STADTCGA-BR-A4PE-01AMBNL1chr3

152018156

+ABCC5chr3

183732235

-
ChimerDB4STADTCGA-BR-A4PEMBNL1chr3

152018156

+ABCC5chr3

183732235

-


Top

Fusion Gene ORF analysis for MBNL1-ABCC5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000461436ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
3UTR-5UTRENST00000461436ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
3UTR-5UTRENST00000461436ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
3UTR-5UTRENST00000461436ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
3UTR-5UTRENST00000461436ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
3UTR-5UTRENST00000461436ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
3UTR-5UTRENST00000461436ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
3UTR-5UTRENST00000461436ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
3UTR-5UTRENST00000461436ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
3UTR-5UTRENST00000461436ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
3UTR-intronENST00000461436ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
3UTR-intronENST00000461436ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
3UTR-intronENST00000461436ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
3UTR-intronENST00000461436ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000282486ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000282486ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000282486ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000282486ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000282486ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000282488ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000282488ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000282488ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000282488ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000282488ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000324196ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000324196ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000324196ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000324196ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000324196ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000324210ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000324210ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000324210ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000324210ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000324210ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000355460ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000355460ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000355460ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000355460ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000355460ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000357472ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000357472ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000357472ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000357472ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000357472ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000463374ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000463374ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000463374ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000463374ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000463374ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000485509ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000485509ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000485509ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000485509ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000485509ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000485910ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000485910ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000485910ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000485910ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000485910ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000492948ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000492948ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000492948ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000492948ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000492948ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000498502ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000498502ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000498502ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000498502ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000498502ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000545754ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000545754ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000545754ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000545754ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-5UTRENST00000545754ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000282486ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000282486ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000282488ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000282488ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000324196ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000324196ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000324210ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000324210ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000355460ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000355460ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000357472ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000357472ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000463374ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000463374ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000485509ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000485509ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000485910ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000485910ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000492948ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000492948ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000498502ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000498502ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000545754ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5CDS-intronENST00000545754ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000282486ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000282486ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000282486ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000282486ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000282486ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000282488ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000282488ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000282488ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000282488ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000282488ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000324210ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000324210ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000324210ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000324210ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000324210ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000355460ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000355460ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000355460ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000355460ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000355460ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000493459ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000493459ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000493459ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000493459ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-5UTRENST00000493459ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-intronENST00000282486ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-intronENST00000282486ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-intronENST00000282488ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-intronENST00000282488ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-intronENST00000324210ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-intronENST00000324210ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-intronENST00000355460ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-intronENST00000355460ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-intronENST00000493459ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
5UTR-intronENST00000493459ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000324196ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000324196ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000324196ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000324196ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000324196ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000357472ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000357472ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000357472ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000357472ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000357472ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000463374ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000463374ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000463374ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000463374ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000463374ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000485509ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000485509ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000485509ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000485509ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000485509ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000485910ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000485910ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000485910ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000485910ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000485910ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000492948ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000492948ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000492948ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000492948ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000492948ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000493459ENST00000334444MBNL1chr3

152018156

+ABCC5chr3

183732235

-
intron-5UTRENST00000493459ENST00000382494MBNL1chr3

152018156

+ABCC5chr3

183732235

-
intron-5UTRENST00000493459ENST00000392579MBNL1chr3

152018156

+ABCC5chr3

183732235

-
intron-5UTRENST00000493459ENST00000427120MBNL1chr3

152018156

+ABCC5chr3

183732235

-
intron-5UTRENST00000493459ENST00000446941MBNL1chr3

152018156

+ABCC5chr3

183732235

-
intron-5UTRENST00000498502ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000498502ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000498502ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000498502ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000498502ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000545754ENST00000334444MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000545754ENST00000382494MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000545754ENST00000392579MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000545754ENST00000427120MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-5UTRENST00000545754ENST00000446941MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000324196ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000324196ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000357472ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000357472ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000463374ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000463374ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000485509ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000485509ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000485910ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000485910ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000492948ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000492948ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000493459ENST00000265586MBNL1chr3

152018156

+ABCC5chr3

183732235

-
intron-intronENST00000493459ENST00000492216MBNL1chr3

152018156

+ABCC5chr3

183732235

-
intron-intronENST00000498502ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000498502ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000545754ENST00000265586MBNL1chr3

151986881

+ABCC5chr3

183732235

-
intron-intronENST00000545754ENST00000492216MBNL1chr3

151986881

+ABCC5chr3

183732235

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MBNL1-ABCC5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MBNL1-ABCC5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:152018156/:183732235)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBNL1

Q9NR56

ABCC5

O15440

FUNCTION: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. {ECO:0000269|PubMed:10970838, ECO:0000269|PubMed:15257297, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:19470458}.FUNCTION: Acts as a multispecific organic anion pump which can transport nucleotide analogs. Heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). {ECO:0000269|PubMed:10840050, ECO:0000269|PubMed:24836561}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MBNL1-ABCC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MBNL1-ABCC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MBNL1-ABCC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MBNL1-ABCC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource