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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MBNL2-HS6ST3 (FusionGDB2 ID:52021)

Fusion Gene Summary for MBNL2-HS6ST3

check button Fusion gene summary
Fusion gene informationFusion gene name: MBNL2-HS6ST3
Fusion gene ID: 52021
HgeneTgene
Gene symbol

MBNL2

HS6ST3

Gene ID

10150

266722

Gene namemuscleblind like splicing regulator 2heparan sulfate 6-O-sulfotransferase 3
SynonymsMBLL|MBLL39|PRO2032HS6ST-3
Cytomap

13q32.1

13q32.1

Type of geneprotein-codingprotein-coding
Descriptionmuscleblind-like protein 2muscleblind-like 2muscleblind-like protein 1muscleblind-like protein-like 39heparan-sulfate 6-O-sulfotransferase 3
Modification date2020031320200313
UniProtAcc

Q5VZF2

Q8IZP7

Ensembl transtripts involved in fusion geneENST00000343600, ENST00000345429, 
ENST00000376673, ENST00000397601, 
ENST00000445661, 		ENST00000376705, 
Fusion gene scores* DoF score10 X 9 X 6=5409 X 10 X 3=270
# samples 1110
** MAII scorelog2(11/540*10)=-2.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBNL2 [Title/Abstract] AND HS6ST3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMBNL2(97928663)-HS6ST3(97484744), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMBNL2

GO:0043484

regulation of RNA splicing

15257297|16946708


check buttonFusion gene breakpoints across MBNL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HS6ST3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8373-01AMBNL2chr13

97928663

-HS6ST3chr13

97484744

+
ChimerDB4STADTCGA-BR-8373-01AMBNL2chr13

97928663

+HS6ST3chr13

97484744

+
ChimerDB4STADTCGA-BR-8373MBNL2chr13

97928663

+HS6ST3chr13

97484743

+


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Fusion Gene ORF analysis for MBNL2-HS6ST3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000343600ENST00000376705MBNL2chr13

97928663

+HS6ST3chr13

97484744

+
In-frameENST00000343600ENST00000376705MBNL2chr13

97928663

+HS6ST3chr13

97484743

+
In-frameENST00000345429ENST00000376705MBNL2chr13

97928663

+HS6ST3chr13

97484744

+
In-frameENST00000345429ENST00000376705MBNL2chr13

97928663

+HS6ST3chr13

97484743

+
In-frameENST00000376673ENST00000376705MBNL2chr13

97928663

+HS6ST3chr13

97484744

+
In-frameENST00000376673ENST00000376705MBNL2chr13

97928663

+HS6ST3chr13

97484743

+
In-frameENST00000397601ENST00000376705MBNL2chr13

97928663

+HS6ST3chr13

97484744

+
In-frameENST00000397601ENST00000376705MBNL2chr13

97928663

+HS6ST3chr13

97484743

+
In-frameENST00000445661ENST00000376705MBNL2chr13

97928663

+HS6ST3chr13

97484744

+
In-frameENST00000445661ENST00000376705MBNL2chr13

97928663

+HS6ST3chr13

97484743

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397601MBNL2chr1397928663+ENST00000376705HS6ST3chr1397484744+18329049231612229
ENST00000343600MBNL2chr1397928663+ENST00000376705HS6ST3chr1397484744+191899010091698229
ENST00000345429MBNL2chr1397928663+ENST00000376705HS6ST3chr1397484744+18839559741663229
ENST00000376673MBNL2chr1397928663+ENST00000376705HS6ST3chr1397484744+18839559741663229
ENST00000445661MBNL2chr1397928663+ENST00000376705HS6ST3chr1397484744+1134206225914229
ENST00000397601MBNL2chr1397928663+ENST00000376705HS6ST3chr1397484743+18329049231612229
ENST00000343600MBNL2chr1397928663+ENST00000376705HS6ST3chr1397484743+191899010091698229
ENST00000345429MBNL2chr1397928663+ENST00000376705HS6ST3chr1397484743+18839559741663229
ENST00000376673MBNL2chr1397928663+ENST00000376705HS6ST3chr1397484743+18839559741663229
ENST00000445661MBNL2chr1397928663+ENST00000376705HS6ST3chr1397484743+1134206225914229

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397601ENST00000376705MBNL2chr1397928663+HS6ST3chr1397484744+0.0022854090.99771464
ENST00000343600ENST00000376705MBNL2chr1397928663+HS6ST3chr1397484744+0.0021750710.9978249
ENST00000345429ENST00000376705MBNL2chr1397928663+HS6ST3chr1397484744+0.0019854990.99801445
ENST00000376673ENST00000376705MBNL2chr1397928663+HS6ST3chr1397484744+0.0019854990.99801445
ENST00000445661ENST00000376705MBNL2chr1397928663+HS6ST3chr1397484744+0.0039365290.99606353
ENST00000397601ENST00000376705MBNL2chr1397928663+HS6ST3chr1397484743+0.0022854090.99771464
ENST00000343600ENST00000376705MBNL2chr1397928663+HS6ST3chr1397484743+0.0021750710.9978249
ENST00000345429ENST00000376705MBNL2chr1397928663+HS6ST3chr1397484743+0.0019854990.99801445
ENST00000376673ENST00000376705MBNL2chr1397928663+HS6ST3chr1397484743+0.0019854990.99801445
ENST00000445661ENST00000376705MBNL2chr1397928663+HS6ST3chr1397484743+0.0039365290.99606353

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Fusion Genomic Features for MBNL2-HS6ST3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MBNL2-HS6ST3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:97928663/chr13:97484744)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBNL2

Q5VZF2

HS6ST3

Q8IZP7

FUNCTION: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). {ECO:0000269|PubMed:15257297, ECO:0000269|PubMed:16273094, ECO:0000269|PubMed:16946708}.FUNCTION: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMBNL2chr13:97928663chr13:97484743ENST00000343600+2713_4158362.0Zinc fingerC3H1-type 1
HgeneMBNL2chr13:97928663chr13:97484743ENST00000345429+2913_4158368.0Zinc fingerC3H1-type 1
HgeneMBNL2chr13:97928663chr13:97484743ENST00000376673+2813_4158374.0Zinc fingerC3H1-type 1
HgeneMBNL2chr13:97928663chr13:97484743ENST00000397601+2713_4158362.0Zinc fingerC3H1-type 1
HgeneMBNL2chr13:97928663chr13:97484744ENST00000343600+2713_4158362.0Zinc fingerC3H1-type 1
HgeneMBNL2chr13:97928663chr13:97484744ENST00000345429+2913_4158368.0Zinc fingerC3H1-type 1
HgeneMBNL2chr13:97928663chr13:97484744ENST00000376673+2813_4158374.0Zinc fingerC3H1-type 1
HgeneMBNL2chr13:97928663chr13:97484744ENST00000397601+2713_4158362.0Zinc fingerC3H1-type 1
TgeneHS6ST3chr13:97928663chr13:97484743ENST0000037670502377_379235472.0RegionPAPS binding
TgeneHS6ST3chr13:97928663chr13:97484743ENST0000037670502383_384235472.0RegionPAPS binding
TgeneHS6ST3chr13:97928663chr13:97484744ENST0000037670502377_379235472.0RegionPAPS binding
TgeneHS6ST3chr13:97928663chr13:97484744ENST0000037670502383_384235472.0RegionPAPS binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMBNL2chr13:97928663chr13:97484743ENST00000343600+27176_20458362.0Zinc fingerC3H1-type 3
HgeneMBNL2chr13:97928663chr13:97484743ENST00000343600+27212_23858362.0Zinc fingerC3H1-type 4
HgeneMBNL2chr13:97928663chr13:97484743ENST00000343600+2747_7358362.0Zinc fingerC3H1-type 2
HgeneMBNL2chr13:97928663chr13:97484743ENST00000345429+29176_20458368.0Zinc fingerC3H1-type 3
HgeneMBNL2chr13:97928663chr13:97484743ENST00000345429+29212_23858368.0Zinc fingerC3H1-type 4
HgeneMBNL2chr13:97928663chr13:97484743ENST00000345429+2947_7358368.0Zinc fingerC3H1-type 2
HgeneMBNL2chr13:97928663chr13:97484743ENST00000376673+28176_20458374.0Zinc fingerC3H1-type 3
HgeneMBNL2chr13:97928663chr13:97484743ENST00000376673+28212_23858374.0Zinc fingerC3H1-type 4
HgeneMBNL2chr13:97928663chr13:97484743ENST00000376673+2847_7358374.0Zinc fingerC3H1-type 2
HgeneMBNL2chr13:97928663chr13:97484743ENST00000397601+27176_20458362.0Zinc fingerC3H1-type 3
HgeneMBNL2chr13:97928663chr13:97484743ENST00000397601+27212_23858362.0Zinc fingerC3H1-type 4
HgeneMBNL2chr13:97928663chr13:97484743ENST00000397601+2747_7358362.0Zinc fingerC3H1-type 2
HgeneMBNL2chr13:97928663chr13:97484744ENST00000343600+27176_20458362.0Zinc fingerC3H1-type 3
HgeneMBNL2chr13:97928663chr13:97484744ENST00000343600+27212_23858362.0Zinc fingerC3H1-type 4
HgeneMBNL2chr13:97928663chr13:97484744ENST00000343600+2747_7358362.0Zinc fingerC3H1-type 2
HgeneMBNL2chr13:97928663chr13:97484744ENST00000345429+29176_20458368.0Zinc fingerC3H1-type 3
HgeneMBNL2chr13:97928663chr13:97484744ENST00000345429+29212_23858368.0Zinc fingerC3H1-type 4
HgeneMBNL2chr13:97928663chr13:97484744ENST00000345429+2947_7358368.0Zinc fingerC3H1-type 2
HgeneMBNL2chr13:97928663chr13:97484744ENST00000376673+28176_20458374.0Zinc fingerC3H1-type 3
HgeneMBNL2chr13:97928663chr13:97484744ENST00000376673+28212_23858374.0Zinc fingerC3H1-type 4
HgeneMBNL2chr13:97928663chr13:97484744ENST00000376673+2847_7358374.0Zinc fingerC3H1-type 2
HgeneMBNL2chr13:97928663chr13:97484744ENST00000397601+27176_20458362.0Zinc fingerC3H1-type 3
HgeneMBNL2chr13:97928663chr13:97484744ENST00000397601+27212_23858362.0Zinc fingerC3H1-type 4
HgeneMBNL2chr13:97928663chr13:97484744ENST00000397601+2747_7358362.0Zinc fingerC3H1-type 2
TgeneHS6ST3chr13:97928663chr13:97484743ENST0000037670502152_160235472.0RegionPAPS binding
TgeneHS6ST3chr13:97928663chr13:97484743ENST0000037670502182_183235472.0RegionSubstrate binding
TgeneHS6ST3chr13:97928663chr13:97484744ENST0000037670502152_160235472.0RegionPAPS binding
TgeneHS6ST3chr13:97928663chr13:97484744ENST0000037670502182_183235472.0RegionSubstrate binding
TgeneHS6ST3chr13:97928663chr13:97484743ENST00000376705021_4235472.0Topological domainCytoplasmic
TgeneHS6ST3chr13:97928663chr13:97484743ENST000003767050228_471235472.0Topological domainLumenal
TgeneHS6ST3chr13:97928663chr13:97484744ENST00000376705021_4235472.0Topological domainCytoplasmic
TgeneHS6ST3chr13:97928663chr13:97484744ENST000003767050228_471235472.0Topological domainLumenal
TgeneHS6ST3chr13:97928663chr13:97484743ENST00000376705025_27235472.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneHS6ST3chr13:97928663chr13:97484744ENST00000376705025_27235472.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for MBNL2-HS6ST3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52021_52021_1_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000343600_HS6ST3_chr13_97484743_ENST00000376705_length(transcript)=1918nt_BP=990nt
AGCAACAGAGTTTAGACTGTCTTTGCTTCATCATCTGAAGGTAAAATTTTCCAGATACGGCAGACGGCTTTCAGAGTACAATAAACAGGG
AATGAGAACTATTTACATGGAAGTTTCTTTCTCATGATGCGGTGGAGAAGCCTCGGCCACTTGGTTCTGCCAGATGTTCCTGGGGTTACT
GTAAATGGGAAGGACAGGCAGAGCTAAACAAGGTTTATCATTTAAAAGTGCCTGTGTGAAGTCACTTTTGCTGGAAAACTGCAGCTTGGG
AGCTTTCTTTGTATTCACATCCCACTCTTCTGTCAAGTACACTTTACCCTGACCTTATGAGTGGATGAAGATACCTCAGTTGTCTGACTT
TGCCAATTGCTTAATTTCAGAATTTAAAAAGGGGAAAGAAAAACATCCTGCTAAAATATGAACATCTGAGTGTCTTATTTTCCAACATCG
TCAATAGCTGTGAGCGTCAGCATTAAATATTCTCCCAAGGAGTGCCATGATATTGAAGTCACTTTATTAATAACAGCTGTATCTGCAAAA
CAGTCAAGAGACTCGGACGTTGAAAGCCAGAGATGACACTGAGCATGCTTTTATTGCGGCCTACCATCTTTAAGTGGGACATATTGATTG
ATGAGTGATTGCCTGTCCATACACTCTCTCATCATCCTGTTCCTTGGATTGGACTTCACTAAGCAATTTATCACTCACCTTCAGACTTAC
ATGTGGGAGTTTTCACAACAGTAGTTTTGGAATCATTAGAACTTGGATTGATTTCATCATTTAACAGAAACAAACAGCCCAAATTACTTT
ATCACCATGGCTTTGAACGTTGCCCCAGTCAGAGATACAAAATGGCTGACATTAGAAGTCTGCAGACAGTTTCAAAGAGGAACATGCTCA
CGCTCTGATGAAGAATGCAAATTTGCTCATCCCCCCAAAAGTTGTCAGGTTGAAAATGGAAGAGTAATTGCCTGCTTTGATTCCCTAAAG
GAATTTCTATTACATCACAATGTTACGGGATCCAGTGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAAAAC
CTCTCTTCATATGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGGGTCAGCTTGCG
GGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGCTGACCTCAGCCTGGTGGGCTGCTATAACTTGAC
TTTCATGAACGAGAGTGAAAGAAACACCATCCTGTTGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTT
CCAGAGGAAGACACAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCGGGCTTCTAA
CGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGCAGCTTTACGAGTATGCAAAAGATCTCTTCCA
GCAGCGCTACCACCACACCAAGCAGCTAGAGCACCAGAGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGA
CCACCAGTGGCCCAAAGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGACCTCCTGCCCT
CTCCTCTCTCAGGAGGGGGAGGGTGAGCAGGCACATTGACTTTCTGTTGAGGTACCTTGGAGAAGCTGAGCCATTCTGAGGACATCTGGC
TGTGTGTGCTTGATTTGGACATCTTCTTCCTTCTTTGTCTTCATTTTTATCCAGCTGGAGATTATCCGTCTTGTTCTTTTTTTTCTTGAC

>52021_52021_1_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000343600_HS6ST3_chr13_97484743_ENST00000376705_length(amino acids)=229AA_BP=
MLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESE
RNTILLQSAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHT

--------------------------------------------------------------
>52021_52021_2_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000343600_HS6ST3_chr13_97484744_ENST00000376705_length(transcript)=1918nt_BP=990nt
AGCAACAGAGTTTAGACTGTCTTTGCTTCATCATCTGAAGGTAAAATTTTCCAGATACGGCAGACGGCTTTCAGAGTACAATAAACAGGG
AATGAGAACTATTTACATGGAAGTTTCTTTCTCATGATGCGGTGGAGAAGCCTCGGCCACTTGGTTCTGCCAGATGTTCCTGGGGTTACT
GTAAATGGGAAGGACAGGCAGAGCTAAACAAGGTTTATCATTTAAAAGTGCCTGTGTGAAGTCACTTTTGCTGGAAAACTGCAGCTTGGG
AGCTTTCTTTGTATTCACATCCCACTCTTCTGTCAAGTACACTTTACCCTGACCTTATGAGTGGATGAAGATACCTCAGTTGTCTGACTT
TGCCAATTGCTTAATTTCAGAATTTAAAAAGGGGAAAGAAAAACATCCTGCTAAAATATGAACATCTGAGTGTCTTATTTTCCAACATCG
TCAATAGCTGTGAGCGTCAGCATTAAATATTCTCCCAAGGAGTGCCATGATATTGAAGTCACTTTATTAATAACAGCTGTATCTGCAAAA
CAGTCAAGAGACTCGGACGTTGAAAGCCAGAGATGACACTGAGCATGCTTTTATTGCGGCCTACCATCTTTAAGTGGGACATATTGATTG
ATGAGTGATTGCCTGTCCATACACTCTCTCATCATCCTGTTCCTTGGATTGGACTTCACTAAGCAATTTATCACTCACCTTCAGACTTAC
ATGTGGGAGTTTTCACAACAGTAGTTTTGGAATCATTAGAACTTGGATTGATTTCATCATTTAACAGAAACAAACAGCCCAAATTACTTT
ATCACCATGGCTTTGAACGTTGCCCCAGTCAGAGATACAAAATGGCTGACATTAGAAGTCTGCAGACAGTTTCAAAGAGGAACATGCTCA
CGCTCTGATGAAGAATGCAAATTTGCTCATCCCCCCAAAAGTTGTCAGGTTGAAAATGGAAGAGTAATTGCCTGCTTTGATTCCCTAAAG
GAATTTCTATTACATCACAATGTTACGGGATCCAGTGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAAAAC
CTCTCTTCATATGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGGGTCAGCTTGCG
GGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGCTGACCTCAGCCTGGTGGGCTGCTATAACTTGAC
TTTCATGAACGAGAGTGAAAGAAACACCATCCTGTTGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTT
CCAGAGGAAGACACAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCGGGCTTCTAA
CGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGCAGCTTTACGAGTATGCAAAAGATCTCTTCCA
GCAGCGCTACCACCACACCAAGCAGCTAGAGCACCAGAGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGA
CCACCAGTGGCCCAAAGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGACCTCCTGCCCT
CTCCTCTCTCAGGAGGGGGAGGGTGAGCAGGCACATTGACTTTCTGTTGAGGTACCTTGGAGAAGCTGAGCCATTCTGAGGACATCTGGC
TGTGTGTGCTTGATTTGGACATCTTCTTCCTTCTTTGTCTTCATTTTTATCCAGCTGGAGATTATCCGTCTTGTTCTTTTTTTTCTTGAC

>52021_52021_2_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000343600_HS6ST3_chr13_97484744_ENST00000376705_length(amino acids)=229AA_BP=
MLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESE
RNTILLQSAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHT

--------------------------------------------------------------
>52021_52021_3_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000345429_HS6ST3_chr13_97484743_ENST00000376705_length(transcript)=1883nt_BP=955nt
TGAAGGTAAAATTTTCCAGATACGGCAGACGGCTTTCAGAGTACAATAAACAGGGAATGAGAACTATTTACATGGAAGTTTCTTTCTCAT
GATGCGGTGGAGAAGCCTCGGCCACTTGGTTCTGCCAGATGTTCCTGGGGTTACTGTAAATGGGAAGGACAGGCAGAGCTAAACAAGGTT
TATCATTTAAAAGTGCCTGTGTGAAGTCACTTTTGCTGGAAAACTGCAGCTTGGGAGCTTTCTTTGTATTCACATCCCACTCTTCTGTCA
AGTACACTTTACCCTGACCTTATGAGTGGATGAAGATACCTCAGTTGTCTGACTTTGCCAATTGCTTAATTTCAGAATTTAAAAAGGGGA
AAGAAAAACATCCTGCTAAAATATGAACATCTGAGTGTCTTATTTTCCAACATCGTCAATAGCTGTGAGCGTCAGCATTAAATATTCTCC
CAAGGAGTGCCATGATATTGAAGTCACTTTATTAATAACAGCTGTATCTGCAAAACAGTCAAGAGACTCGGACGTTGAAAGCCAGAGATG
ACACTGAGCATGCTTTTATTGCGGCCTACCATCTTTAAGTGGGACATATTGATTGATGAGTGATTGCCTGTCCATACACTCTCTCATCAT
CCTGTTCCTTGGATTGGACTTCACTAAGCAATTTATCACTCACCTTCAGACTTACATGTGGGAGTTTTCACAACAGTAGTTTTGGAATCA
TTAGAACTTGGATTGATTTCATCATTTAACAGAAACAAACAGCCCAAATTACTTTATCACCATGGCTTTGAACGTTGCCCCAGTCAGAGA
TACAAAATGGCTGACATTAGAAGTCTGCAGACAGTTTCAAAGAGGAACATGCTCACGCTCTGATGAAGAATGCAAATTTGCTCATCCCCC
CAAAAGTTGTCAGGTTGAAAATGGAAGAGTAATTGCCTGCTTTGATTCCCTAAAGGAATTTCTATTACATCACAATGTTACGGGATCCAG
TGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATATGTGTGATGGAAGAAGCCCCACCC
CAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGGGTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACA
ATCGCCAGGTGCGCATGCTGGCTGACCTCAGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGT
TGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACACAGTTTCTCTTTGAGAGAACAT
TCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCGGGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTG
AGGATCTAAACTTCCTGGACATGCAGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACC
AGAGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAAAGAAGATGGGGCTGCAGAAG
GGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGACCTCCTGCCCTCTCCTCTCTCAGGAGGGGGAGGGTGAGCAGGCACA
TTGACTTTCTGTTGAGGTACCTTGGAGAAGCTGAGCCATTCTGAGGACATCTGGCTGTGTGTGCTTGATTTGGACATCTTCTTCCTTCTT

>52021_52021_3_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000345429_HS6ST3_chr13_97484743_ENST00000376705_length(amino acids)=229AA_BP=
MLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESE
RNTILLQSAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHT

--------------------------------------------------------------
>52021_52021_4_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000345429_HS6ST3_chr13_97484744_ENST00000376705_length(transcript)=1883nt_BP=955nt
TGAAGGTAAAATTTTCCAGATACGGCAGACGGCTTTCAGAGTACAATAAACAGGGAATGAGAACTATTTACATGGAAGTTTCTTTCTCAT
GATGCGGTGGAGAAGCCTCGGCCACTTGGTTCTGCCAGATGTTCCTGGGGTTACTGTAAATGGGAAGGACAGGCAGAGCTAAACAAGGTT
TATCATTTAAAAGTGCCTGTGTGAAGTCACTTTTGCTGGAAAACTGCAGCTTGGGAGCTTTCTTTGTATTCACATCCCACTCTTCTGTCA
AGTACACTTTACCCTGACCTTATGAGTGGATGAAGATACCTCAGTTGTCTGACTTTGCCAATTGCTTAATTTCAGAATTTAAAAAGGGGA
AAGAAAAACATCCTGCTAAAATATGAACATCTGAGTGTCTTATTTTCCAACATCGTCAATAGCTGTGAGCGTCAGCATTAAATATTCTCC
CAAGGAGTGCCATGATATTGAAGTCACTTTATTAATAACAGCTGTATCTGCAAAACAGTCAAGAGACTCGGACGTTGAAAGCCAGAGATG
ACACTGAGCATGCTTTTATTGCGGCCTACCATCTTTAAGTGGGACATATTGATTGATGAGTGATTGCCTGTCCATACACTCTCTCATCAT
CCTGTTCCTTGGATTGGACTTCACTAAGCAATTTATCACTCACCTTCAGACTTACATGTGGGAGTTTTCACAACAGTAGTTTTGGAATCA
TTAGAACTTGGATTGATTTCATCATTTAACAGAAACAAACAGCCCAAATTACTTTATCACCATGGCTTTGAACGTTGCCCCAGTCAGAGA
TACAAAATGGCTGACATTAGAAGTCTGCAGACAGTTTCAAAGAGGAACATGCTCACGCTCTGATGAAGAATGCAAATTTGCTCATCCCCC
CAAAAGTTGTCAGGTTGAAAATGGAAGAGTAATTGCCTGCTTTGATTCCCTAAAGGAATTTCTATTACATCACAATGTTACGGGATCCAG
TGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATATGTGTGATGGAAGAAGCCCCACCC
CAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGGGTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACA
ATCGCCAGGTGCGCATGCTGGCTGACCTCAGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGT
TGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACACAGTTTCTCTTTGAGAGAACAT
TCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCGGGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTG
AGGATCTAAACTTCCTGGACATGCAGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACC
AGAGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAAAGAAGATGGGGCTGCAGAAG
GGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGACCTCCTGCCCTCTCCTCTCTCAGGAGGGGGAGGGTGAGCAGGCACA
TTGACTTTCTGTTGAGGTACCTTGGAGAAGCTGAGCCATTCTGAGGACATCTGGCTGTGTGTGCTTGATTTGGACATCTTCTTCCTTCTT

>52021_52021_4_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000345429_HS6ST3_chr13_97484744_ENST00000376705_length(amino acids)=229AA_BP=
MLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESE
RNTILLQSAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHT

--------------------------------------------------------------
>52021_52021_5_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000376673_HS6ST3_chr13_97484743_ENST00000376705_length(transcript)=1883nt_BP=955nt
TGAAGGTAAAATTTTCCAGATACGGCAGACGGCTTTCAGAGTACAATAAACAGGGAATGAGAACTATTTACATGGAAGTTTCTTTCTCAT
GATGCGGTGGAGAAGCCTCGGCCACTTGGTTCTGCCAGATGTTCCTGGGGTTACTGTAAATGGGAAGGACAGGCAGAGCTAAACAAGGTT
TATCATTTAAAAGTGCCTGTGTGAAGTCACTTTTGCTGGAAAACTGCAGCTTGGGAGCTTTCTTTGTATTCACATCCCACTCTTCTGTCA
AGTACACTTTACCCTGACCTTATGAGTGGATGAAGATACCTCAGTTGTCTGACTTTGCCAATTGCTTAATTTCAGAATTTAAAAAGGGGA
AAGAAAAACATCCTGCTAAAATATGAACATCTGAGTGTCTTATTTTCCAACATCGTCAATAGCTGTGAGCGTCAGCATTAAATATTCTCC
CAAGGAGTGCCATGATATTGAAGTCACTTTATTAATAACAGCTGTATCTGCAAAACAGTCAAGAGACTCGGACGTTGAAAGCCAGAGATG
ACACTGAGCATGCTTTTATTGCGGCCTACCATCTTTAAGTGGGACATATTGATTGATGAGTGATTGCCTGTCCATACACTCTCTCATCAT
CCTGTTCCTTGGATTGGACTTCACTAAGCAATTTATCACTCACCTTCAGACTTACATGTGGGAGTTTTCACAACAGTAGTTTTGGAATCA
TTAGAACTTGGATTGATTTCATCATTTAACAGAAACAAACAGCCCAAATTACTTTATCACCATGGCTTTGAACGTTGCCCCAGTCAGAGA
TACAAAATGGCTGACATTAGAAGTCTGCAGACAGTTTCAAAGAGGAACATGCTCACGCTCTGATGAAGAATGCAAATTTGCTCATCCCCC
CAAAAGTTGTCAGGTTGAAAATGGAAGAGTAATTGCCTGCTTTGATTCCCTAAAGGAATTTCTATTACATCACAATGTTACGGGATCCAG
TGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATATGTGTGATGGAAGAAGCCCCACCC
CAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGGGTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACA
ATCGCCAGGTGCGCATGCTGGCTGACCTCAGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGT
TGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACACAGTTTCTCTTTGAGAGAACAT
TCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCGGGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTG
AGGATCTAAACTTCCTGGACATGCAGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACC
AGAGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAAAGAAGATGGGGCTGCAGAAG
GGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGACCTCCTGCCCTCTCCTCTCTCAGGAGGGGGAGGGTGAGCAGGCACA
TTGACTTTCTGTTGAGGTACCTTGGAGAAGCTGAGCCATTCTGAGGACATCTGGCTGTGTGTGCTTGATTTGGACATCTTCTTCCTTCTT

>52021_52021_5_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000376673_HS6ST3_chr13_97484743_ENST00000376705_length(amino acids)=229AA_BP=
MLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESE
RNTILLQSAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHT

--------------------------------------------------------------
>52021_52021_6_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000376673_HS6ST3_chr13_97484744_ENST00000376705_length(transcript)=1883nt_BP=955nt
TGAAGGTAAAATTTTCCAGATACGGCAGACGGCTTTCAGAGTACAATAAACAGGGAATGAGAACTATTTACATGGAAGTTTCTTTCTCAT
GATGCGGTGGAGAAGCCTCGGCCACTTGGTTCTGCCAGATGTTCCTGGGGTTACTGTAAATGGGAAGGACAGGCAGAGCTAAACAAGGTT
TATCATTTAAAAGTGCCTGTGTGAAGTCACTTTTGCTGGAAAACTGCAGCTTGGGAGCTTTCTTTGTATTCACATCCCACTCTTCTGTCA
AGTACACTTTACCCTGACCTTATGAGTGGATGAAGATACCTCAGTTGTCTGACTTTGCCAATTGCTTAATTTCAGAATTTAAAAAGGGGA
AAGAAAAACATCCTGCTAAAATATGAACATCTGAGTGTCTTATTTTCCAACATCGTCAATAGCTGTGAGCGTCAGCATTAAATATTCTCC
CAAGGAGTGCCATGATATTGAAGTCACTTTATTAATAACAGCTGTATCTGCAAAACAGTCAAGAGACTCGGACGTTGAAAGCCAGAGATG
ACACTGAGCATGCTTTTATTGCGGCCTACCATCTTTAAGTGGGACATATTGATTGATGAGTGATTGCCTGTCCATACACTCTCTCATCAT
CCTGTTCCTTGGATTGGACTTCACTAAGCAATTTATCACTCACCTTCAGACTTACATGTGGGAGTTTTCACAACAGTAGTTTTGGAATCA
TTAGAACTTGGATTGATTTCATCATTTAACAGAAACAAACAGCCCAAATTACTTTATCACCATGGCTTTGAACGTTGCCCCAGTCAGAGA
TACAAAATGGCTGACATTAGAAGTCTGCAGACAGTTTCAAAGAGGAACATGCTCACGCTCTGATGAAGAATGCAAATTTGCTCATCCCCC
CAAAAGTTGTCAGGTTGAAAATGGAAGAGTAATTGCCTGCTTTGATTCCCTAAAGGAATTTCTATTACATCACAATGTTACGGGATCCAG
TGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATATGTGTGATGGAAGAAGCCCCACCC
CAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGGGTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACA
ATCGCCAGGTGCGCATGCTGGCTGACCTCAGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGT
TGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACACAGTTTCTCTTTGAGAGAACAT
TCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCGGGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTG
AGGATCTAAACTTCCTGGACATGCAGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACC
AGAGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAAAGAAGATGGGGCTGCAGAAG
GGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGACCTCCTGCCCTCTCCTCTCTCAGGAGGGGGAGGGTGAGCAGGCACA
TTGACTTTCTGTTGAGGTACCTTGGAGAAGCTGAGCCATTCTGAGGACATCTGGCTGTGTGTGCTTGATTTGGACATCTTCTTCCTTCTT

>52021_52021_6_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000376673_HS6ST3_chr13_97484744_ENST00000376705_length(amino acids)=229AA_BP=
MLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESE
RNTILLQSAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHT

--------------------------------------------------------------
>52021_52021_7_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000397601_HS6ST3_chr13_97484743_ENST00000376705_length(transcript)=1832nt_BP=904nt
CAGGAAACTCCAGCACCTCCTAGAACATCTTTTGTGGAATGGCACCTCATGGGGGCCCTTGGATCATGTACCCCTTGTATTCAACAGTAA
ACATCTTCCTATAATCATTGCTTCATTAACGATAATGTTTATCATTTAAAAGTGCCTGTGTGAAGTCACTTTTGCTGGAAAACTGCAGCT
TGGGAGCTTTCTTTGTATTCACATCCCACTCTTCTGTCAAGTACACTTTACCCTGACCTTATGAGTGGATGAAGATACCTCAGTTGTCTG
ACTTTGCCAATTGCTTAATTTCAGAATTTAAAAAGGGGAAAGAAAAACATCCTGCTAAAATATGAACATCTGAGTGTCTTATTTTCCAAC
ATCGTCAATAGCTGTGAGCGTCAGCATTAAATATTCTCCCAAGGAGTGCCATGATATTGAAGTCACTTTATTAATAACAGCTGTATCTGC
AAAACAGTCAAGAGACTCGGACGTTGAAAGCCAGAGATGACACTGAGCATGCTTTTATTGCGGCCTACCATCTTTAAGTGGGACATATTG
ATTGATGAGTGATTGCCTGTCCATACACTCTCTCATCATCCTGTTCCTTGGATTGGACTTCACTAAGCAATTTATCACTCACCTTCAGAC
TTACATGTGGGAGTTTTCACAACAGTAGTTTTGGAATCATTAGAACTTGGATTGATTTCATCATTTAACAGAAACAAACAGCCCAAATTA
CTTTATCACCATGGCTTTGAACGTTGCCCCAGTCAGAGATACAAAATGGCTGACATTAGAAGTCTGCAGACAGTTTCAAAGAGGAACATG
CTCACGCTCTGATGAAGAATGCAAATTTGCTCATCCCCCCAAAAGTTGTCAGGTTGAAAATGGAAGAGTAATTGCCTGCTTTGATTCCCT
AAAGGAATTTCTATTACATCACAATGTTACGGGATCCAGTGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGA
AAACCTCTCTTCATATGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGGGTCAGCT
TGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGCTGACCTCAGCCTGGTGGGCTGCTATAACT
TGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGTTGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTG
AGTTCCAGAGGAAGACACAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCGGGCTT
CTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGCAGCTTTACGAGTATGCAAAAGATCTCT
TCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACCAGAGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACA
GGGACCACCAGTGGCCCAAAGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGACCTCCTG
CCCTCTCCTCTCTCAGGAGGGGGAGGGTGAGCAGGCACATTGACTTTCTGTTGAGGTACCTTGGAGAAGCTGAGCCATTCTGAGGACATC
TGGCTGTGTGTGCTTGATTTGGACATCTTCTTCCTTCTTTGTCTTCATTTTTATCCAGCTGGAGATTATCCGTCTTGTTCTTTTTTTTCT

>52021_52021_7_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000397601_HS6ST3_chr13_97484743_ENST00000376705_length(amino acids)=229AA_BP=
MLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESE
RNTILLQSAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHT

--------------------------------------------------------------
>52021_52021_8_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000397601_HS6ST3_chr13_97484744_ENST00000376705_length(transcript)=1832nt_BP=904nt
CAGGAAACTCCAGCACCTCCTAGAACATCTTTTGTGGAATGGCACCTCATGGGGGCCCTTGGATCATGTACCCCTTGTATTCAACAGTAA
ACATCTTCCTATAATCATTGCTTCATTAACGATAATGTTTATCATTTAAAAGTGCCTGTGTGAAGTCACTTTTGCTGGAAAACTGCAGCT
TGGGAGCTTTCTTTGTATTCACATCCCACTCTTCTGTCAAGTACACTTTACCCTGACCTTATGAGTGGATGAAGATACCTCAGTTGTCTG
ACTTTGCCAATTGCTTAATTTCAGAATTTAAAAAGGGGAAAGAAAAACATCCTGCTAAAATATGAACATCTGAGTGTCTTATTTTCCAAC
ATCGTCAATAGCTGTGAGCGTCAGCATTAAATATTCTCCCAAGGAGTGCCATGATATTGAAGTCACTTTATTAATAACAGCTGTATCTGC
AAAACAGTCAAGAGACTCGGACGTTGAAAGCCAGAGATGACACTGAGCATGCTTTTATTGCGGCCTACCATCTTTAAGTGGGACATATTG
ATTGATGAGTGATTGCCTGTCCATACACTCTCTCATCATCCTGTTCCTTGGATTGGACTTCACTAAGCAATTTATCACTCACCTTCAGAC
TTACATGTGGGAGTTTTCACAACAGTAGTTTTGGAATCATTAGAACTTGGATTGATTTCATCATTTAACAGAAACAAACAGCCCAAATTA
CTTTATCACCATGGCTTTGAACGTTGCCCCAGTCAGAGATACAAAATGGCTGACATTAGAAGTCTGCAGACAGTTTCAAAGAGGAACATG
CTCACGCTCTGATGAAGAATGCAAATTTGCTCATCCCCCCAAAAGTTGTCAGGTTGAAAATGGAAGAGTAATTGCCTGCTTTGATTCCCT
AAAGGAATTTCTATTACATCACAATGTTACGGGATCCAGTGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGA
AAACCTCTCTTCATATGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGGGTCAGCT
TGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGCTGACCTCAGCCTGGTGGGCTGCTATAACT
TGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGTTGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTG
AGTTCCAGAGGAAGACACAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCGGGCTT
CTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGCAGCTTTACGAGTATGCAAAAGATCTCT
TCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACCAGAGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACA
GGGACCACCAGTGGCCCAAAGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGACCTCCTG
CCCTCTCCTCTCTCAGGAGGGGGAGGGTGAGCAGGCACATTGACTTTCTGTTGAGGTACCTTGGAGAAGCTGAGCCATTCTGAGGACATC
TGGCTGTGTGTGCTTGATTTGGACATCTTCTTCCTTCTTTGTCTTCATTTTTATCCAGCTGGAGATTATCCGTCTTGTTCTTTTTTTTCT

>52021_52021_8_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000397601_HS6ST3_chr13_97484744_ENST00000376705_length(amino acids)=229AA_BP=
MLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESE
RNTILLQSAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHT

--------------------------------------------------------------
>52021_52021_9_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000445661_HS6ST3_chr13_97484743_ENST00000376705_length(transcript)=1134nt_BP=206nt
CAGAAACAAACAGCCCAAATTACTTTATCACCATGGCTTTGAACGTTGCCCCAGTCAGAGATACAAAATGGCTGACATTAGAAGTCTGCA
GACAGTTTCAAAGAGGAACATGCTCACGCTCTGATGAAGAATGCAAATTTGCTCATCCCCCCAAAAGTTGTCAGGTTGAAAATGGAAGAG
TAATTGCCTGCTTTGATTCCCTAAAGGAATTTCTATTACATCACAATGTTACGGGATCCAGTGTCACGTTACCTGAGCGAGTGGAAACAT
GTCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATATGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGG
GATGACTGGTCTGGGGTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGCTGACCTC
AGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGTTGCAGAGTGCAAAGAACAACCTGAAGAAC
ATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACACAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACA
CAGTTCAACATCACGCGGGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGCAGCTT
TACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACCAGAGGGACCGCCAGAAGCGGCGGGAGGAG
CGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAAAGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAG
GTGGTGAGATGGTGACCTCCTGCCCTCTCCTCTCTCAGGAGGGGGAGGGTGAGCAGGCACATTGACTTTCTGTTGAGGTACCTTGGAGAA
GCTGAGCCATTCTGAGGACATCTGGCTGTGTGTGCTTGATTTGGACATCTTCTTCCTTCTTTGTCTTCATTTTTATCCAGCTGGAGATTA

>52021_52021_9_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000445661_HS6ST3_chr13_97484743_ENST00000376705_length(amino acids)=229AA_BP=
MLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESE
RNTILLQSAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHT

--------------------------------------------------------------
>52021_52021_10_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000445661_HS6ST3_chr13_97484744_ENST00000376705_length(transcript)=1134nt_BP=206nt
CAGAAACAAACAGCCCAAATTACTTTATCACCATGGCTTTGAACGTTGCCCCAGTCAGAGATACAAAATGGCTGACATTAGAAGTCTGCA
GACAGTTTCAAAGAGGAACATGCTCACGCTCTGATGAAGAATGCAAATTTGCTCATCCCCCCAAAAGTTGTCAGGTTGAAAATGGAAGAG
TAATTGCCTGCTTTGATTCCCTAAAGGAATTTCTATTACATCACAATGTTACGGGATCCAGTGTCACGTTACCTGAGCGAGTGGAAACAT
GTCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATATGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGG
GATGACTGGTCTGGGGTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGCTGACCTC
AGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGTTGCAGAGTGCAAAGAACAACCTGAAGAAC
ATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACACAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACA
CAGTTCAACATCACGCGGGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGCAGCTT
TACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACCAGAGGGACCGCCAGAAGCGGCGGGAGGAG
CGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAAAGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAG
GTGGTGAGATGGTGACCTCCTGCCCTCTCCTCTCTCAGGAGGGGGAGGGTGAGCAGGCACATTGACTTTCTGTTGAGGTACCTTGGAGAA
GCTGAGCCATTCTGAGGACATCTGGCTGTGTGTGCTTGATTTGGACATCTTCTTCCTTCTTTGTCTTCATTTTTATCCAGCTGGAGATTA

>52021_52021_10_MBNL2-HS6ST3_MBNL2_chr13_97928663_ENST00000445661_HS6ST3_chr13_97484744_ENST00000376705_length(amino acids)=229AA_BP=
MLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESE
RNTILLQSAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MBNL2-HS6ST3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MBNL2-HS6ST3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MBNL2-HS6ST3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource