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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MBOAT7-MBOAT7 (FusionGDB2 ID:52060)

Fusion Gene Summary for MBOAT7-MBOAT7

check button Fusion gene summary
Fusion gene informationFusion gene name: MBOAT7-MBOAT7
Fusion gene ID: 52060
HgeneTgene
Gene symbol

MBOAT7

MBOAT7

Gene ID

79143

79143

Gene namemembrane bound O-acyltransferase domain containing 7membrane bound O-acyltransferase domain containing 7
SynonymsBB1|LENG4|LPIAT|LPLAT|LRC4|MBOA7|MRT57|OACT7|hMBOA-7BB1|LENG4|LPIAT|LPLAT|LRC4|MBOA7|MRT57|OACT7|hMBOA-7
Cytomap

19q13.42

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionlysophospholipid acyltransferase 71-acylglycerophosphatidylinositol O-acyltransferaseLPLAT 7bladder and breast carcinoma-overexpressed gene 1 proteinh-mboa-7leukocyte receptor cluster (LRC) member 4lyso-PI acyltransferaselysophosphatidylinositol aclysophospholipid acyltransferase 71-acylglycerophosphatidylinositol O-acyltransferaseLPLAT 7bladder and breast carcinoma-overexpressed gene 1 proteinh-mboa-7leukocyte receptor cluster (LRC) member 4lyso-PI acyltransferaselysophosphatidylinositol ac
Modification date2020031320200313
UniProtAcc

Q96N66

Q96N66

Ensembl transtripts involved in fusion geneENST00000245615, ENST00000338624, 
ENST00000391754, ENST00000431666, 
ENST00000474910, 		ENST00000474910, 
ENST00000245615, ENST00000338624, 
ENST00000391754, ENST00000431666, 
Fusion gene scores* DoF score5 X 4 X 4=807 X 7 X 3=147
# samples 59
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/147*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBOAT7 [Title/Abstract] AND MBOAT7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMBOAT7(54688505)-MBOAT7(54691069), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MBOAT7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MBOAT7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF919648MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-


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Fusion Gene ORF analysis for MBOAT7-MBOAT7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000245615ENST00000474910MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-5UTRENST00000338624ENST00000474910MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-5UTRENST00000391754ENST00000474910MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-5UTRENST00000431666ENST00000474910MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-5UTRENST00000474910ENST00000474910MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000245615ENST00000245615MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000245615ENST00000338624MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000245615ENST00000391754MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000245615ENST00000431666MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000338624ENST00000245615MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000338624ENST00000338624MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000338624ENST00000391754MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000338624ENST00000431666MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000391754ENST00000245615MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000391754ENST00000338624MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000391754ENST00000391754MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000391754ENST00000431666MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000431666ENST00000245615MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000431666ENST00000338624MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000431666ENST00000391754MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000431666ENST00000431666MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000474910ENST00000245615MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000474910ENST00000338624MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000474910ENST00000391754MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000474910ENST00000431666MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MBOAT7-MBOAT7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MBOAT7-MBOAT7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:54688505/:54691069)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBOAT7

Q96N66

MBOAT7

Q96N66

FUNCTION: Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128, PubMed:18094042). Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell (PubMed:18772128, PubMed:18094042). In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation (PubMed:32253259). {ECO:0000269|PubMed:18094042, ECO:0000269|PubMed:18772128, ECO:0000269|PubMed:32253259}.FUNCTION: Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128, PubMed:18094042). Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell (PubMed:18772128, PubMed:18094042). In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation (PubMed:32253259). {ECO:0000269|PubMed:18094042, ECO:0000269|PubMed:18772128, ECO:0000269|PubMed:32253259}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MBOAT7-MBOAT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MBOAT7-MBOAT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MBOAT7-MBOAT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MBOAT7-MBOAT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource