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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MBOAT7-TARM1 (FusionGDB2 ID:52061)

Fusion Gene Summary for MBOAT7-TARM1

Fusion gene summary

Fusion gene information	Fusion gene name: MBOAT7-TARM1
	Fusion gene ID: 52061
		Hgene	Tgene
	Gene symbol	MBOAT7	TARM1
	Gene ID	79143	441864
	Gene name	membrane bound O-acyltransferase domain containing 7	T cell-interacting, activating receptor on myeloid cells 1
	Synonyms	BB1\|LENG4\|LPIAT\|LPLAT\|LRC4\|MBOA7\|MRT57\|OACT7\|hMBOA-7	OLT-2
	Cytomap	19q13.42	19q13.42
	Type of gene	protein-coding	protein-coding
	Description	lysophospholipid acyltransferase 71-acylglycerophosphatidylinositol O-acyltransferaseLPLAT 7bladder and breast carcinoma-overexpressed gene 1 proteinh-mboa-7leukocyte receptor cluster (LRC) member 4lyso-PI acyltransferaselysophosphatidylinositol ac	T-cell-interacting, activating receptor on myeloid cells protein 1OSCAR-like transcript-2 protein
	Modification date	20200313	20200313
	UniProtAcc	Q96N66	.
	Ensembl transtripts involved in fusion gene	ENST00000431666, ENST00000245615, ENST00000338624, ENST00000391754, ENST00000474910,	ENST00000432826, ENST00000446034,
Fusion gene scores	* DoF score	5 X 4 X 4=80	4 X 5 X 4=80
	# samples	5	5
	** MAII score	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MBOAT7 [Title/Abstract] AND TARM1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MBOAT7(54682482)-TARM1(54573414), # samples:1
Anticipated loss of major functional domain due to fusion event.	MBOAT7-TARM1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. MBOAT7-TARM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TARM1	GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	26311901

Fusion gene breakpoints across MBOAT7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TARM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-60-2721-01A	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-

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Fusion Gene ORF analysis for MBOAT7-TARM1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000431666	ENST00000432826	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-
Frame-shift	ENST00000431666	ENST00000446034	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-
In-frame	ENST00000245615	ENST00000432826	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-
In-frame	ENST00000245615	ENST00000446034	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-
In-frame	ENST00000338624	ENST00000432826	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-
In-frame	ENST00000338624	ENST00000446034	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-
intron-3CDS	ENST00000391754	ENST00000432826	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-
intron-3CDS	ENST00000391754	ENST00000446034	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-
intron-3CDS	ENST00000474910	ENST00000432826	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-
intron-3CDS	ENST00000474910	ENST00000446034	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000338624	MBOAT7	chr19	54682482	-	ENST00000446034	TARM1	chr19	54573414	-	1325	1059	13	1098	361
ENST00000338624	MBOAT7	chr19	54682482	-	ENST00000432826	TARM1	chr19	54573414	-	1273	1059	13	1098	361
ENST00000245615	MBOAT7	chr19	54682482	-	ENST00000446034	TARM1	chr19	54573414	-	1778	1512	346	1551	401
ENST00000245615	MBOAT7	chr19	54682482	-	ENST00000432826	TARM1	chr19	54573414	-	1726	1512	346	1551	401

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000338624	ENST00000446034	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-	0.30744928	0.6925507
ENST00000338624	ENST00000432826	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-	0.3134133	0.68658674
ENST00000245615	ENST00000446034	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-	0.104561605	0.8954384
ENST00000245615	ENST00000432826	MBOAT7	chr19	54682482	-	TARM1	chr19	54573414	-	0.111161634	0.8888384

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Fusion Genomic Features for MBOAT7-TARM1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MBOAT7-TARM1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:54682482/chr19:54573414)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MBOAT7 Q96N66	.
FUNCTION: Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128, PubMed:18094042). Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell (PubMed:18772128, PubMed:18094042). In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation (PubMed:32253259). {ECO:0000269\|PubMed:18094042, ECO:0000269\|PubMed:18772128, ECO:0000269\|PubMed:32253259}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

1_5

343

473.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

213_231

343

473.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

23_33

343

473.0

Topological domain

Lumenal

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

58_73

343

473.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

94_194

343

473.0

Topological domain

Lumenal

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

1_5

270

400.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

213_231

270

400.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

23_33

270

400.0

Topological domain

Lumenal

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

58_73

270

400.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

94_194

270

400.0

Topological domain

Lumenal

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

1_5

270

400.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

213_231

270

400.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

23_33

270

400.0

Topological domain

Lumenal

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

58_73

270

400.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

94_194

270

400.0

Topological domain

Lumenal

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

195_212

343

473.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

232_261

343

473.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

34_57

343

473.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

6_22

343

473.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

74_93

343

473.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

195_212

270

400.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

232_261

270

400.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

34_57

270

400.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

6_22

270

400.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

74_93

270

400.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

195_212

270

400.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

232_261

270

400.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

34_57

270

400.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

6_22

270

400.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

74_93

270

400.0

Transmembrane

Helical

Tgene

TARM1

chr19:54682482

chr19:54573414

ENST00000432826

258_271

219

272.0

Topological domain

Cytoplasmic

Tgene

TARM1

chr19:54682482

chr19:54573414

ENST00000446034

258_271

227

280.0

Topological domain

Cytoplasmic

Tgene

TARM1

chr19:54682482

chr19:54573414

ENST00000432826

237_257

219

272.0

Transmembrane

Helical

Tgene

TARM1

chr19:54682482

chr19:54573414

ENST00000446034

237_257

227

280.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

262_426

343

473.0

Topological domain

Lumenal

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

448_472

343

473.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

262_426

270

400.0

Topological domain

Lumenal

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

448_472

270

400.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

1_5

345.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

213_231

345.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

23_33

345.0

Topological domain

Lumenal

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

262_426

345.0

Topological domain

Lumenal

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

448_472

345.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

58_73

345.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

94_194

345.0

Topological domain

Lumenal

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

262_426

270

400.0

Topological domain

Lumenal

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

448_472

270

400.0

Topological domain

Cytoplasmic

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000245615

427_447

343

473.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000338624

427_447

270

400.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

195_212

345.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

232_261

345.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

34_57

345.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

427_447

345.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

6_22

345.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000391754

74_93

345.0

Transmembrane

Helical

Hgene

MBOAT7

chr19:54682482

chr19:54573414

ENST00000431666

427_447

270

400.0

Transmembrane

Helical

Tgene

TARM1

chr19:54682482

chr19:54573414

ENST00000432826

126_212

219

272.0

Domain

Ig-like C2-type 2

Tgene

TARM1

chr19:54682482

chr19:54573414

ENST00000432826

27_113

219

272.0

Domain

Ig-like C2-type 1

Tgene

TARM1

chr19:54682482

chr19:54573414

ENST00000446034

126_212

227

280.0

Domain

Ig-like C2-type 2

Tgene

TARM1

chr19:54682482

chr19:54573414

ENST00000446034

27_113

227

280.0

Domain

Ig-like C2-type 1

Tgene

TARM1

chr19:54682482

chr19:54573414

ENST00000432826

17_236

219

272.0

Topological domain

Extracellular

Tgene

TARM1

chr19:54682482

chr19:54573414

ENST00000446034

17_236

227

280.0

Topological domain

Extracellular

Top

Fusion Gene Sequence for MBOAT7-TARM1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>52061_52061_1_MBOAT7-TARM1_MBOAT7_chr19_54682482_ENST00000245615_TARM1_chr19_54573414_ENST00000432826_length(transcript)=1726nt_BP=1512nt
GTTCTCGACTATTGCCGAAGTGAGCCGAAGTTTGTGGCCCCGCTTCCGGAGAACTCAAGCTCCCGATTGTGCCCGAAGGAACCCGAAGGG
AGACCCCGCCTCATTCCTCACGGCGAGCTCCAGACCCCGCCTCCTTTCCGGAGCCCGTCTGTTCCCCTTCGGGTCCAAAGCTTTTGGCTC
CTCCTTGTTCCGAGCCCGAAGGCCCGCCCCTTCACGTACTCGGAGCTCGGATCCCAGTGTGGACCTGGACTCGAATCCCGTTGCCGACTC
GCGCTCTCGGCTTCTGCTCCGGGGCTTCTTCCCTGCCCGCCCGGGGCCCTGACCGTGGCTTCTTCCCCGGCCTGATCTGCGCAGCCCGGC
GGGCGCCCAGAAGGAGCAGGCGGCGCGGGGGCGCGCTGGGCGGGGGAGGCGTGGCCGGAGCTGCGGCGGCAAGCGGGCTGGGACTGCTCG
GCCGCCTCCTGCCCGGCGAGCAGCTCAGACCATGTCGCCTGAAGAATGGACGTATCTAGTGGTTCTTCTTATCTCCATCCCCATCGGCTT
CCTCTTTAAGAAAGCCGGTCCTGGGCTGAAGAGATGGGGAGCAGCCGCTGTGGGCCTGGGGCTCACCCTGTTCACCTGTGGCCCCCACAC
TTTGCATTCTCTGGTCACCATCCTCGGGACCTGGGCCCTCATTCAGGCCCAGCCCTGCTCCTGCCACGCCCTGGCTCTGGCCTGGACTTT
CTCCTATCTCCTGTTCTTCCGAGCCCTCAGCCTCCTGGGCCTGCCCACTCCCACGCCCTTCACCAATGCCGTCCAGCTGCTGCTGACGCT
GAAGCTGGTGAGCCTGGCCAGTGAAGTCCAGGACCTGCATCTGGCCCAGAGGAAGGAAATGGCCTCAGGCTTCAGCAAGGGGCCCACCCT
GGGGCTGCTGCCCGACGTGCCCTCCCTGATGGAGACACTCAGCTACAGCTACTGCTACGTGGGAATCATGACAGGCCCGTTCTTCCGCTA
CCGCACCTACCTGGACTGGCTGGAGCAGCCCTTCCCCGGGGCAGTGCCCAGCCTGCGGCCCCTGCTGCGCCGCGCCTGGCCGGCCCCGCT
CTTCGGCCTGCTGTTCCTGCTCTCCTCTCACCTCTTCCCGCTGGAGGCCGTGCGCGAGGACGCCTTCTACGCCCGCCCGCTGCCCGCCCG
CCTCTTCTACATGATCCCCGTCTTCTTCGCCTTCCGCATGCGCTTCTACGTGGCCTGGATTGCCGCCGAGTGCGGCTGCATTGCCGCCGG
CTTTGGGGCCTACCCCGTGGCCGCCAAAGCCCGGGCCGGAGGCGGCCCCACCCTCCAATGCCCACCCCCCAGCAGTCCGGAGAAGGCGGC
TTCCTTGGAGTATGACTATGAGACCATCCGCAACATCGACTGCTACAGCACAGATTTCTGCGTGCGGGTGCGCGATGGCATGCGGTACTG
GAACATGACGGTGCAGTGGTGGCTGGCGCAGTATATCTACAAGAGCGCACCTGCCCGTTCCTATGTCCTGCGTTCCCCCAGGTACCACAT
CGAGCAACTACTCCCTGGGTAACTTCGTACGACTGGGTCTGGCTGCCGTAATTGTGGTTATCATGGGAGCTTTCCTGGTGGAGGCCTGGT
ACAGCCGGAATGTGTCTCCAGGTGAATCAGAGGCCTTCAAACCAGAGTGACTCCATCTTGAACCGGGGCTGGGTAAACTGAGGCTGCAAC

>52061_52061_1_MBOAT7-TARM1_MBOAT7_chr19_54682482_ENST00000245615_TARM1_chr19_54573414_ENST00000432826_length(amino acids)=401AA_BP=1
MRSPAGAQKEQAARGRAGRGRRGRSCGGKRAGTARPPPARRAAQTMSPEEWTYLVVLLISIPIGFLFKKAGPGLKRWGAAAVGLGLTLFT
CGPHTLHSLVTILGTWALIQAQPCSCHALALAWTFSYLLFFRALSLLGLPTPTPFTNAVQLLLTLKLVSLASEVQDLHLAQRKEMASGFS
KGPTLGLLPDVPSLMETLSYSYCYVGIMTGPFFRYRTYLDWLEQPFPGAVPSLRPLLRRAWPAPLFGLLFLLSSHLFPLEAVREDAFYAR
PLPARLFYMIPVFFAFRMRFYVAWIAAECGCIAAGFGAYPVAAKARAGGGPTLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFCVRVRD

--------------------------------------------------------------
>52061_52061_2_MBOAT7-TARM1_MBOAT7_chr19_54682482_ENST00000245615_TARM1_chr19_54573414_ENST00000446034_length(transcript)=1778nt_BP=1512nt
GTTCTCGACTATTGCCGAAGTGAGCCGAAGTTTGTGGCCCCGCTTCCGGAGAACTCAAGCTCCCGATTGTGCCCGAAGGAACCCGAAGGG
AGACCCCGCCTCATTCCTCACGGCGAGCTCCAGACCCCGCCTCCTTTCCGGAGCCCGTCTGTTCCCCTTCGGGTCCAAAGCTTTTGGCTC
CTCCTTGTTCCGAGCCCGAAGGCCCGCCCCTTCACGTACTCGGAGCTCGGATCCCAGTGTGGACCTGGACTCGAATCCCGTTGCCGACTC
GCGCTCTCGGCTTCTGCTCCGGGGCTTCTTCCCTGCCCGCCCGGGGCCCTGACCGTGGCTTCTTCCCCGGCCTGATCTGCGCAGCCCGGC
GGGCGCCCAGAAGGAGCAGGCGGCGCGGGGGCGCGCTGGGCGGGGGAGGCGTGGCCGGAGCTGCGGCGGCAAGCGGGCTGGGACTGCTCG
GCCGCCTCCTGCCCGGCGAGCAGCTCAGACCATGTCGCCTGAAGAATGGACGTATCTAGTGGTTCTTCTTATCTCCATCCCCATCGGCTT
CCTCTTTAAGAAAGCCGGTCCTGGGCTGAAGAGATGGGGAGCAGCCGCTGTGGGCCTGGGGCTCACCCTGTTCACCTGTGGCCCCCACAC
TTTGCATTCTCTGGTCACCATCCTCGGGACCTGGGCCCTCATTCAGGCCCAGCCCTGCTCCTGCCACGCCCTGGCTCTGGCCTGGACTTT
CTCCTATCTCCTGTTCTTCCGAGCCCTCAGCCTCCTGGGCCTGCCCACTCCCACGCCCTTCACCAATGCCGTCCAGCTGCTGCTGACGCT
GAAGCTGGTGAGCCTGGCCAGTGAAGTCCAGGACCTGCATCTGGCCCAGAGGAAGGAAATGGCCTCAGGCTTCAGCAAGGGGCCCACCCT
GGGGCTGCTGCCCGACGTGCCCTCCCTGATGGAGACACTCAGCTACAGCTACTGCTACGTGGGAATCATGACAGGCCCGTTCTTCCGCTA
CCGCACCTACCTGGACTGGCTGGAGCAGCCCTTCCCCGGGGCAGTGCCCAGCCTGCGGCCCCTGCTGCGCCGCGCCTGGCCGGCCCCGCT
CTTCGGCCTGCTGTTCCTGCTCTCCTCTCACCTCTTCCCGCTGGAGGCCGTGCGCGAGGACGCCTTCTACGCCCGCCCGCTGCCCGCCCG
CCTCTTCTACATGATCCCCGTCTTCTTCGCCTTCCGCATGCGCTTCTACGTGGCCTGGATTGCCGCCGAGTGCGGCTGCATTGCCGCCGG
CTTTGGGGCCTACCCCGTGGCCGCCAAAGCCCGGGCCGGAGGCGGCCCCACCCTCCAATGCCCACCCCCCAGCAGTCCGGAGAAGGCGGC
TTCCTTGGAGTATGACTATGAGACCATCCGCAACATCGACTGCTACAGCACAGATTTCTGCGTGCGGGTGCGCGATGGCATGCGGTACTG
GAACATGACGGTGCAGTGGTGGCTGGCGCAGTATATCTACAAGAGCGCACCTGCCCGTTCCTATGTCCTGCGTTCCCCCAGGTACCACAT
CGAGCAACTACTCCCTGGGTAACTTCGTACGACTGGGTCTGGCTGCCGTAATTGTGGTTATCATGGGAGCTTTCCTGGTGGAGGCCTGGT
ACAGCCGGAATGTGTCTCCAGGTGAATCAGAGGCCTTCAAACCAGAGTGACTCCATCTTGAACCGGGGCTGGGTAAACTGAGGCTGCAAC

>52061_52061_2_MBOAT7-TARM1_MBOAT7_chr19_54682482_ENST00000245615_TARM1_chr19_54573414_ENST00000446034_length(amino acids)=401AA_BP=1
MRSPAGAQKEQAARGRAGRGRRGRSCGGKRAGTARPPPARRAAQTMSPEEWTYLVVLLISIPIGFLFKKAGPGLKRWGAAAVGLGLTLFT
CGPHTLHSLVTILGTWALIQAQPCSCHALALAWTFSYLLFFRALSLLGLPTPTPFTNAVQLLLTLKLVSLASEVQDLHLAQRKEMASGFS
KGPTLGLLPDVPSLMETLSYSYCYVGIMTGPFFRYRTYLDWLEQPFPGAVPSLRPLLRRAWPAPLFGLLFLLSSHLFPLEAVREDAFYAR
PLPARLFYMIPVFFAFRMRFYVAWIAAECGCIAAGFGAYPVAAKARAGGGPTLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFCVRVRD

--------------------------------------------------------------
>52061_52061_3_MBOAT7-TARM1_MBOAT7_chr19_54682482_ENST00000338624_TARM1_chr19_54573414_ENST00000432826_length(transcript)=1273nt_BP=1059nt
GACTCGAATCCCGTTGCCGACTCGCGCTCTCGGCTTCTGCTCCGGGGCTTCTTCCCTGCCCGCCCGGGGCCCTGACCGTGGCTTCTTCCC
CGGCCTGATCTGCGCAGCCCGGCGGGCGCCCAGAAGGAGCAGGCGGCGCGGGGGCGCGCTGGGCGGGGGAGGCGTGGCCGGAGCTGCGGC
GGCAAGCGGGCTGGGACTGCTCGGCCGCCTCCTGCCCGGCGAGCAGCTCAGGTCCTGGGCTGAAGAGATGGGGAGCAGCCGCTGTGGGCC
TGGGGCTCACCCTGTTCACCTGTGGCCCCCACACTTTGCATTCTCTGGTCACCATCCTCGGGACCTGGGCCCTCATTCAGGCCCAGCCCT
GCTGGTGAGCCTGGCCAGTGAAGTCCAGGACCTGCATCTGGCCCAGAGGAAGGAAATGGCCTCAGGCTTCAGCAAGGGGCCCACCCTGGG
GCTGCTGCCCGACGTGCCCTCCCTGATGGAGACACTCAGCTACAGCTACTGCTACGTGGGAATCATGACAGGCCCGTTCTTCCGCTACCG
CACCTACCTGGACTGGCTGGAGCAGCCCTTCCCCGGGGCAGTGCCCAGCCTGCGGCCCCTGCTGCGCCGCGCCTGGCCGGCCCCGCTCTT
CGGCCTGCTGTTCCTGCTCTCCTCTCACCTCTTCCCGCTGGAGGCCGTGCGCGAGGACGCCTTCTACGCCCGCCCGCTGCCCGCCCGCCT
CTTCTACATGATCCCCGTCTTCTTCGCCTTCCGCATGCGCTTCTACGTGGCCTGGATTGCCGCCGAGTGCGGCTGCATTGCCGCCGGCTT
TGGGGCCTACCCCGTGGCCGCCAAAGCCCGGGCCGGAGGCGGCCCCACCCTCCAATGCCCACCCCCCAGCAGTCCGGAGAAGGCGGCTTC
CTTGGAGTATGACTATGAGACCATCCGCAACATCGACTGCTACAGCACAGATTTCTGCGTGCGGGTGCGCGATGGCATGCGGTACTGGAA
CATGACGGTGCAGTGGTGGCTGGCGCAGTATATCTACAAGAGCGCACCTGCCCGTTCCTATGTCCTGCGTTCCCCCAGGTACCACATCGA
GCAACTACTCCCTGGGTAACTTCGTACGACTGGGTCTGGCTGCCGTAATTGTGGTTATCATGGGAGCTTTCCTGGTGGAGGCCTGGTACA
GCCGGAATGTGTCTCCAGGTGAATCAGAGGCCTTCAAACCAGAGTGACTCCATCTTGAACCGGGGCTGGGTAAACTGAGGCTGCAACCTG

>52061_52061_3_MBOAT7-TARM1_MBOAT7_chr19_54682482_ENST00000338624_TARM1_chr19_54573414_ENST00000432826_length(amino acids)=361AA_BP=1
MPTRALGFCSGASSLPARGPDRGFFPGLICAARRAPRRSRRRGGALGGGGVAGAAAASGLGLLGRLLPGEQLRSWAEEMGSSRCGPGAHP
VHLWPPHFAFSGHHPRDLGPHSGPALLVSLASEVQDLHLAQRKEMASGFSKGPTLGLLPDVPSLMETLSYSYCYVGIMTGPFFRYRTYLD
WLEQPFPGAVPSLRPLLRRAWPAPLFGLLFLLSSHLFPLEAVREDAFYARPLPARLFYMIPVFFAFRMRFYVAWIAAECGCIAAGFGAYP
VAAKARAGGGPTLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFCVRVRDGMRYWNMTVQWWLAQYIYKSAPARSYVLRSPRYHIEQLLP

--------------------------------------------------------------
>52061_52061_4_MBOAT7-TARM1_MBOAT7_chr19_54682482_ENST00000338624_TARM1_chr19_54573414_ENST00000446034_length(transcript)=1325nt_BP=1059nt
GACTCGAATCCCGTTGCCGACTCGCGCTCTCGGCTTCTGCTCCGGGGCTTCTTCCCTGCCCGCCCGGGGCCCTGACCGTGGCTTCTTCCC
CGGCCTGATCTGCGCAGCCCGGCGGGCGCCCAGAAGGAGCAGGCGGCGCGGGGGCGCGCTGGGCGGGGGAGGCGTGGCCGGAGCTGCGGC
GGCAAGCGGGCTGGGACTGCTCGGCCGCCTCCTGCCCGGCGAGCAGCTCAGGTCCTGGGCTGAAGAGATGGGGAGCAGCCGCTGTGGGCC
TGGGGCTCACCCTGTTCACCTGTGGCCCCCACACTTTGCATTCTCTGGTCACCATCCTCGGGACCTGGGCCCTCATTCAGGCCCAGCCCT
GCTGGTGAGCCTGGCCAGTGAAGTCCAGGACCTGCATCTGGCCCAGAGGAAGGAAATGGCCTCAGGCTTCAGCAAGGGGCCCACCCTGGG
GCTGCTGCCCGACGTGCCCTCCCTGATGGAGACACTCAGCTACAGCTACTGCTACGTGGGAATCATGACAGGCCCGTTCTTCCGCTACCG
CACCTACCTGGACTGGCTGGAGCAGCCCTTCCCCGGGGCAGTGCCCAGCCTGCGGCCCCTGCTGCGCCGCGCCTGGCCGGCCCCGCTCTT
CGGCCTGCTGTTCCTGCTCTCCTCTCACCTCTTCCCGCTGGAGGCCGTGCGCGAGGACGCCTTCTACGCCCGCCCGCTGCCCGCCCGCCT
CTTCTACATGATCCCCGTCTTCTTCGCCTTCCGCATGCGCTTCTACGTGGCCTGGATTGCCGCCGAGTGCGGCTGCATTGCCGCCGGCTT
TGGGGCCTACCCCGTGGCCGCCAAAGCCCGGGCCGGAGGCGGCCCCACCCTCCAATGCCCACCCCCCAGCAGTCCGGAGAAGGCGGCTTC
CTTGGAGTATGACTATGAGACCATCCGCAACATCGACTGCTACAGCACAGATTTCTGCGTGCGGGTGCGCGATGGCATGCGGTACTGGAA
CATGACGGTGCAGTGGTGGCTGGCGCAGTATATCTACAAGAGCGCACCTGCCCGTTCCTATGTCCTGCGTTCCCCCAGGTACCACATCGA
GCAACTACTCCCTGGGTAACTTCGTACGACTGGGTCTGGCTGCCGTAATTGTGGTTATCATGGGAGCTTTCCTGGTGGAGGCCTGGTACA
GCCGGAATGTGTCTCCAGGTGAATCAGAGGCCTTCAAACCAGAGTGACTCCATCTTGAACCGGGGCTGGGTAAACTGAGGCTGCAACCTG

>52061_52061_4_MBOAT7-TARM1_MBOAT7_chr19_54682482_ENST00000338624_TARM1_chr19_54573414_ENST00000446034_length(amino acids)=361AA_BP=1
MPTRALGFCSGASSLPARGPDRGFFPGLICAARRAPRRSRRRGGALGGGGVAGAAAASGLGLLGRLLPGEQLRSWAEEMGSSRCGPGAHP
VHLWPPHFAFSGHHPRDLGPHSGPALLVSLASEVQDLHLAQRKEMASGFSKGPTLGLLPDVPSLMETLSYSYCYVGIMTGPFFRYRTYLD
WLEQPFPGAVPSLRPLLRRAWPAPLFGLLFLLSSHLFPLEAVREDAFYARPLPARLFYMIPVFFAFRMRFYVAWIAAECGCIAAGFGAYP
VAAKARAGGGPTLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFCVRVRDGMRYWNMTVQWWLAQYIYKSAPARSYVLRSPRYHIEQLLP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MBOAT7-TARM1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MBOAT7-TARM1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MBOAT7-TARM1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source