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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MBP-CBLN2 (FusionGDB2 ID:52065)

Fusion Gene Summary for MBP-CBLN2

check button Fusion gene summary
Fusion gene informationFusion gene name: MBP-CBLN2
Fusion gene ID: 52065
HgeneTgene
Gene symbol

MBP

CBLN2

Gene ID

5553

147381

Gene nameproteoglycan 2, pro eosinophil major basic proteincerebellin 2 precursor
SynonymsBMPG|MBP|MBP1|proMBP-
Cytomap

11q12.1

18q22.3

Type of geneprotein-codingprotein-coding
Descriptionbone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)cerebellin-2
Modification date2020031320200313
UniProtAcc.

Q8IUK8

Ensembl transtripts involved in fusion geneENST00000355994, ENST00000397860, 
ENST00000397863, ENST00000579129, 
ENST00000580402, ENST00000487778, 
ENST00000354542, ENST00000359645, 
ENST00000382582, ENST00000397865, 
ENST00000397866, ENST00000397869, 
ENST00000397875, ENST00000526111, 
ENST00000527041, ENST00000528160, 
ENST00000578193, 		ENST00000583651, 
ENST00000269503, ENST00000581073, 
ENST00000584764, ENST00000585159, 
Fusion gene scores* DoF score26 X 20 X 7=36402 X 3 X 2=12
# samples 262
** MAII scorelog2(26/3640*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MBP [Title/Abstract] AND CBLN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMBP(74817167)-CBLN2(70219871), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CBLN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A2QM-01AMBPchr18

74817167

-CBLN2chr18

70206007

-
ChimerDB4UCECTCGA-AJ-A2QM-01AMBPchr18

74817167

-CBLN2chr18

70219871

-


Top

Fusion Gene ORF analysis for MBP-CBLN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000355994ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
5CDS-5UTRENST00000397860ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
5CDS-5UTRENST00000397863ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
5CDS-5UTRENST00000579129ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
5CDS-5UTRENST00000580402ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
5CDS-intronENST00000355994ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000355994ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000355994ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000355994ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000355994ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000397860ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000397860ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000397860ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000397860ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000397860ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000397863ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000397863ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000397863ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000397863ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000397863ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000579129ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000579129ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000579129ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000579129ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000579129ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000580402ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000580402ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000580402ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000580402ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
5CDS-intronENST00000580402ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
5UTR-3CDSENST00000487778ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
5UTR-3CDSENST00000487778ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
5UTR-3CDSENST00000487778ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
5UTR-3CDSENST00000487778ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
5UTR-5UTRENST00000487778ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
5UTR-intronENST00000487778ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
5UTR-intronENST00000487778ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
5UTR-intronENST00000487778ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
5UTR-intronENST00000487778ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
5UTR-intronENST00000487778ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
Frame-shiftENST00000355994ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000355994ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000355994ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000355994ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000397860ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000397860ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000397860ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000397860ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000397863ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000397863ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000397863ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000397863ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000579129ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000579129ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000579129ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
Frame-shiftENST00000579129ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
In-frameENST00000580402ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
In-frameENST00000580402ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
In-frameENST00000580402ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
In-frameENST00000580402ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000354542ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000354542ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000354542ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000354542ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000359645ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000359645ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000359645ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000359645ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000382582ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000382582ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000382582ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000382582ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397865ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397865ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397865ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397865ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397866ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397866ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397866ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397866ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397869ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397869ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397869ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397869ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397875ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397875ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397875ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000397875ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000526111ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000526111ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000526111ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000526111ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000527041ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000527041ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000527041ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000527041ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000528160ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000528160ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000528160ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000528160ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000578193ENST00000269503MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000578193ENST00000581073MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000578193ENST00000584764MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-3CDSENST00000578193ENST00000585159MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-5UTRENST00000354542ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-5UTRENST00000359645ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-5UTRENST00000382582ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-5UTRENST00000397865ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-5UTRENST00000397866ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-5UTRENST00000397869ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-5UTRENST00000397875ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-5UTRENST00000526111ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-5UTRENST00000527041ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-5UTRENST00000528160ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-5UTRENST00000578193ENST00000583651MBPchr18

74817167

-CBLN2chr18

70206007

-
intron-intronENST00000354542ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000354542ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000354542ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000354542ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000354542ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000359645ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000359645ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000359645ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000359645ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000359645ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000382582ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000382582ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000382582ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000382582ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000382582ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397865ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397865ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397865ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397865ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397865ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397866ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397866ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397866ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397866ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397866ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397869ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397869ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397869ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397869ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397869ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397875ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397875ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397875ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397875ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000397875ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000526111ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000526111ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000526111ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000526111ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000526111ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000527041ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000527041ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000527041ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000527041ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000527041ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000528160ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000528160ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000528160ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000528160ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000528160ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000578193ENST00000269503MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000578193ENST00000581073MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000578193ENST00000583651MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000578193ENST00000584764MBPchr18

74817167

-CBLN2chr18

70219871

-
intron-intronENST00000578193ENST00000585159MBPchr18

74817167

-CBLN2chr18

70219871

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000580402MBPchr1874817167-ENST00000581073CBLN2chr1870206007-395510368122
ENST00000580402MBPchr1874817167-ENST00000585159CBLN2chr1870206007-1865516651162165
ENST00000580402MBPchr1874817167-ENST00000269503CBLN2chr1870206007-1865516651162165
ENST00000580402MBPchr1874817167-ENST00000584764CBLN2chr1870206007-525510368122

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000580402ENST00000581073MBPchr1874817167-CBLN2chr1870206007-0.0156856090.98431444
ENST00000580402ENST00000585159MBPchr1874817167-CBLN2chr1870206007-0.378437070.6215629
ENST00000580402ENST00000269503MBPchr1874817167-CBLN2chr1870206007-0.378437070.6215629
ENST00000580402ENST00000584764MBPchr1874817167-CBLN2chr1870206007-0.0127505840.98724943

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Fusion Genomic Features for MBP-CBLN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MBP-CBLN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:74817167/chr18:70219871)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CBLN2

Q8IUK8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (By similarity). {ECO:0000250|UniProtKB:Q8BGU2}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMBPchr18:74817167chr18:70206007ENST00000355994-29179_22217305.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:70206007ENST00000355994-29246_25617305.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:70206007ENST00000359645-16179_2220187.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:70206007ENST00000359645-16246_2560187.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:70206007ENST00000382582-17179_2220198.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:70206007ENST00000382582-17246_2560198.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:70206007ENST00000397860-24179_22217198.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:70206007ENST00000397860-24246_25617198.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:70206007ENST00000397863-24179_22217198.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:70206007ENST00000397863-24246_25617198.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:70206007ENST00000397865-15179_2220161.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:70206007ENST00000397865-15246_2560161.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:70206007ENST00000397866-16179_2220172.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:70206007ENST00000397866-16246_2560172.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:70206007ENST00000580402-18179_22217305.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:70206007ENST00000580402-18246_25617305.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
TgeneCBLN2chr18:74817167chr18:70206007ENST000002695032588_224119225.0DomainC1q
TgeneCBLN2chr18:74817167chr18:70206007ENST000005851591488_224119225.0DomainC1q


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Fusion Gene Sequence for MBP-CBLN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52065_52065_1_MBP-CBLN2_MBP_chr18_74817167_ENST00000580402_CBLN2_chr18_70206007_ENST00000269503_length(transcript)=1865nt_BP=51nt
ATGGGAAACCACGCAGGCAAACGAGAATTAAATGCCGAGAAGGCCAGTACGGTATTAGTAAATATTGGCAACCACTTTGATCTTGCTTCC
AGTATATTTGTAGCACCGAGAAAAGGGATTTATAGCTTCAGCTTCCACGTGGTCAAAGTGTATAACAGACAAACCATCCAGGTCAGTTTA
ATGCAGAATGGCTACCCAGTGATCTCGGCCTTTGCAGGAGACCAGGATGTCACCAGAGAAGCTGCTAGCAATGGCGTGCTGCTGCTCATG
GAAAGGGAAGACAAAGTGCATCTCAAACTTGAGAGAGGCAACCTCATGGGGGGCTGGAAATACTCCACATTCTCGGGCTTCTTGGTGTTT
CCTCTATAAACACAGAGCCCCCTAGATGGTGGGGGAATGGCAAACTGGACCCAGGACTCCGCCCTTTAAAACACCCTGAACTTACTGGAA
TTGGACACCTTGTTTCCAACCTCCGTCAGACTGTTGCAGTAGAAGAATGATTTCCTTTGAAACCTCCAGTACTTTTGTTTTTGTTTTTTG
GAATACTGACAATTCCTCGGGAACCTGGCCTCTAATTAGTTTTAGATGACAAGGTCTTAAGGAGAAATGAAATTATCGATTTGAGCAATT
TGTACCTGTGATTGTAAAGTCAATATCGGATTTTATTGTTGGGACCATGGACCTCTTTTGTTTGTATGTTGTATTGTCGTCCCAACGGAA
GGAGAGCTCCTGACTCCAGGATGGGCTGCAGGTTGCAGTCAGGGCTTGAAGTAGGAGCCCAGCAAAGAACCACCTGCTGGACAGTCCTTG
ACATGTGTTCTGTGTGTGTCTGTATAGCCTTAAGAAAAAGAATGGCTTCACTTTCATTCTGTATTCTTCCCCCCACCATGTGGCTGGGAG
GACTTGGGAGGGGGATGGGGACATTGGGAACCTGTCAAGAAGTGCTTTATCCAGAGAAGCAAATTTTGCACGATTGGACTGCAATTTTTG
TTTTGTATTGTTTGTGTTTTTTCTTGAAAAGCTTTACTTTTCTTTCCACACTCAGCTCTCCCTCCTCAACCCCACTTTTATTTTTCTTGC
TGGGGTTGAGGAGAGAAAATATAGAATTCCTGGATAAGACCAAACAAAACAAAACATTAAAATACCTGTATGTTTTGTTTTAGACGAGAC
CAAACTAAACAAAAAGTATCTGTTTATCAAAGTAAAAGTAACACAATGGACAATTCTGCTTATTCTCTCAAAGAGATTCTAAGATGCACC
TTTAGAACTATTAATAGCAACCTGCATTTTTTTTTAATTTATACTTCAGAATCCTTTAAGAACCTGGTGTTCCTGAGTGGTCCTGAATCA
TATAAGTTGGTAATGGAAGCTGTAATGACCAAGTCCCCTAAACATACTATGTCTTTGCCACGTGTGCTGTGACTTCTCTGTGGGTGATTT
AATTTATTTGGATCCACCTCTGAGTGAGCGCACAGTGATCAGGTGCTTCAAAGCCAACAGACCAGCTCCTCTTCCTCCGGATCCTCTTTT
GATCTGCCCAGGAAAGGGATGCATTGACACTCTCCTGCATGCACCTGGCGAGAAGCCACCTGAAAGTCACTGTGGTTAAAGATATTGGTG
GAGGTACCCCAGGAGCACTGTTACAAATCCTTCTTGTTTTGGCATCTCGTACAACATTATTAAGACACAGCTGAGAGTTGATGGGTGTGT
AATGCATATGCCAAGGAAATGTCACTAATCCCAAAGCAATCAAAAAGGAGACCTCAAACCAGATGTTAATTTGTTCTTTGTGTAACAATG

>52065_52065_1_MBP-CBLN2_MBP_chr18_74817167_ENST00000580402_CBLN2_chr18_70206007_ENST00000269503_length(amino acids)=165AA_BP=
MLGPWTSFVCMLYCRPNGRRAPDSRMGCRLQSGLEVGAQQRTTCWTVLDMCSVCVCIALRKRMASLSFCILPPTMWLGGLGRGMGTLGTC

--------------------------------------------------------------
>52065_52065_2_MBP-CBLN2_MBP_chr18_74817167_ENST00000580402_CBLN2_chr18_70206007_ENST00000581073_length(transcript)=395nt_BP=51nt
ATGGGAAACCACGCAGGCAAACGAGAATTAAATGCCGAGAAGGCCAGTACGGTATTAGTAAATATTGGCAACCACTTTGATCTTGCTTCC
AGTATATTTGTAGCACCGAGAAAAGGGATTTATAGCTTCAGCTTCCACGTGGTCAAAGTGTATAACAGACAAACCATCCAGGTCAGTTTA
ATGCAGAATGGCTACCCAGTGATCTCGGCCTTTGCAGGAGACCAGGATGTCACCAGAGAAGCTGCTAGCAATGGCGTGCTGCTGCTCATG
GAAAGGGAAGACAAAGTGCATCTCAAACTTGAGAGAGGCAACCTCATGGGGGGCTGGAAATACTCCACATTCTCGGGCTTCTTGGTGTTT

>52065_52065_2_MBP-CBLN2_MBP_chr18_74817167_ENST00000580402_CBLN2_chr18_70206007_ENST00000581073_length(amino acids)=122AA_BP=17
MGNHAGKRELNAEKASTVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNRQTIQVSLMQNGYPVISAFAGDQDVTREAASNGVLLLM

--------------------------------------------------------------
>52065_52065_3_MBP-CBLN2_MBP_chr18_74817167_ENST00000580402_CBLN2_chr18_70206007_ENST00000584764_length(transcript)=525nt_BP=51nt
ATGGGAAACCACGCAGGCAAACGAGAATTAAATGCCGAGAAGGCCAGTACGGTATTAGTAAATATTGGCAACCACTTTGATCTTGCTTCC
AGTATATTTGTAGCACCGAGAAAAGGGATTTATAGCTTCAGCTTCCACGTGGTCAAAGTGTATAACAGACAAACCATCCAGGTCAGTTTA
ATGCAGAATGGCTACCCAGTGATCTCGGCCTTTGCAGGAGACCAGGATGTCACCAGAGAAGCTGCTAGCAATGGCGTGCTGCTGCTCATG
GAAAGGGAAGACAAAGTGCATCTCAAACTTGAGAGAGGCAACCTCATGGGGGGCTGGAAATACTCCACATTCTCGGGCTTCTTGGTGTTT
CCTCTATAAACACAGAGCCCCCTAGATGGTGGGGGAATGGCAAACTGGACCCAGGACTCCGCCCTTTAAAACACCCTGAACTTACTGGAA

>52065_52065_3_MBP-CBLN2_MBP_chr18_74817167_ENST00000580402_CBLN2_chr18_70206007_ENST00000584764_length(amino acids)=122AA_BP=17
MGNHAGKRELNAEKASTVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNRQTIQVSLMQNGYPVISAFAGDQDVTREAASNGVLLLM

--------------------------------------------------------------
>52065_52065_4_MBP-CBLN2_MBP_chr18_74817167_ENST00000580402_CBLN2_chr18_70206007_ENST00000585159_length(transcript)=1865nt_BP=51nt
ATGGGAAACCACGCAGGCAAACGAGAATTAAATGCCGAGAAGGCCAGTACGGTATTAGTAAATATTGGCAACCACTTTGATCTTGCTTCC
AGTATATTTGTAGCACCGAGAAAAGGGATTTATAGCTTCAGCTTCCACGTGGTCAAAGTGTATAACAGACAAACCATCCAGGTCAGTTTA
ATGCAGAATGGCTACCCAGTGATCTCGGCCTTTGCAGGAGACCAGGATGTCACCAGAGAAGCTGCTAGCAATGGCGTGCTGCTGCTCATG
GAAAGGGAAGACAAAGTGCATCTCAAACTTGAGAGAGGCAACCTCATGGGGGGCTGGAAATACTCCACATTCTCGGGCTTCTTGGTGTTT
CCTCTATAAACACAGAGCCCCCTAGATGGTGGGGGAATGGCAAACTGGACCCAGGACTCCGCCCTTTAAAACACCCTGAACTTACTGGAA
TTGGACACCTTGTTTCCAACCTCCGTCAGACTGTTGCAGTAGAAGAATGATTTCCTTTGAAACCTCCAGTACTTTTGTTTTTGTTTTTTG
GAATACTGACAATTCCTCGGGAACCTGGCCTCTAATTAGTTTTAGATGACAAGGTCTTAAGGAGAAATGAAATTATCGATTTGAGCAATT
TGTACCTGTGATTGTAAAGTCAATATCGGATTTTATTGTTGGGACCATGGACCTCTTTTGTTTGTATGTTGTATTGTCGTCCCAACGGAA
GGAGAGCTCCTGACTCCAGGATGGGCTGCAGGTTGCAGTCAGGGCTTGAAGTAGGAGCCCAGCAAAGAACCACCTGCTGGACAGTCCTTG
ACATGTGTTCTGTGTGTGTCTGTATAGCCTTAAGAAAAAGAATGGCTTCACTTTCATTCTGTATTCTTCCCCCCACCATGTGGCTGGGAG
GACTTGGGAGGGGGATGGGGACATTGGGAACCTGTCAAGAAGTGCTTTATCCAGAGAAGCAAATTTTGCACGATTGGACTGCAATTTTTG
TTTTGTATTGTTTGTGTTTTTTCTTGAAAAGCTTTACTTTTCTTTCCACACTCAGCTCTCCCTCCTCAACCCCACTTTTATTTTTCTTGC
TGGGGTTGAGGAGAGAAAATATAGAATTCCTGGATAAGACCAAACAAAACAAAACATTAAAATACCTGTATGTTTTGTTTTAGACGAGAC
CAAACTAAACAAAAAGTATCTGTTTATCAAAGTAAAAGTAACACAATGGACAATTCTGCTTATTCTCTCAAAGAGATTCTAAGATGCACC
TTTAGAACTATTAATAGCAACCTGCATTTTTTTTTAATTTATACTTCAGAATCCTTTAAGAACCTGGTGTTCCTGAGTGGTCCTGAATCA
TATAAGTTGGTAATGGAAGCTGTAATGACCAAGTCCCCTAAACATACTATGTCTTTGCCACGTGTGCTGTGACTTCTCTGTGGGTGATTT
AATTTATTTGGATCCACCTCTGAGTGAGCGCACAGTGATCAGGTGCTTCAAAGCCAACAGACCAGCTCCTCTTCCTCCGGATCCTCTTTT
GATCTGCCCAGGAAAGGGATGCATTGACACTCTCCTGCATGCACCTGGCGAGAAGCCACCTGAAAGTCACTGTGGTTAAAGATATTGGTG
GAGGTACCCCAGGAGCACTGTTACAAATCCTTCTTGTTTTGGCATCTCGTACAACATTATTAAGACACAGCTGAGAGTTGATGGGTGTGT
AATGCATATGCCAAGGAAATGTCACTAATCCCAAAGCAATCAAAAAGGAGACCTCAAACCAGATGTTAATTTGTTCTTTGTGTAACAATG

>52065_52065_4_MBP-CBLN2_MBP_chr18_74817167_ENST00000580402_CBLN2_chr18_70206007_ENST00000585159_length(amino acids)=165AA_BP=
MLGPWTSFVCMLYCRPNGRRAPDSRMGCRLQSGLEVGAQQRTTCWTVLDMCSVCVCIALRKRMASLSFCILPPTMWLGGLGRGMGTLGTC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MBP-CBLN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MBP-CBLN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MBP-CBLN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource