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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MBP-ZNF516 (FusionGDB2 ID:52091)

Fusion Gene Summary for MBP-ZNF516

Fusion gene summary

Fusion gene information	Fusion gene name: MBP-ZNF516
	Fusion gene ID: 52091
		Hgene	Tgene
	Gene symbol	MBP	ZNF516
	Gene ID	5553	9658
	Gene name	proteoglycan 2, pro eosinophil major basic protein	zinc finger protein 516
	Synonyms	BMPG\|MBP\|MBP1\|proMBP	HsT287
	Cytomap	11q12.1	18q23
	Type of gene	protein-coding	protein-coding
	Description	bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	zinc finger protein 516
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000355994, ENST00000397860, ENST00000397863, ENST00000579129, ENST00000580402, ENST00000487778, ENST00000354542, ENST00000359645, ENST00000382582, ENST00000397865, ENST00000397866, ENST00000397869, ENST00000397875, ENST00000526111, ENST00000527041, ENST00000528160, ENST00000578193,	ENST00000524431, ENST00000443185,
Fusion gene scores	* DoF score	26 X 20 X 7=3640	3 X 3 X 3=27
	# samples	26	3
	** MAII score	log2(26/3640*10)=-3.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: MBP [Title/Abstract] AND ZNF516 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNF516(74202637)-MBP(74702016), # samples:3 MBP(74817166)-ZNF516(74092259), # samples:2
Anticipated loss of major functional domain due to fusion event.	MBP-ZNF516 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. MBP-ZNF516 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZNF516 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-6942	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-

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Fusion Gene ORF analysis for MBP-ZNF516

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000355994	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
5CDS-5UTR	ENST00000397860	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
5CDS-5UTR	ENST00000397863	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
5CDS-5UTR	ENST00000579129	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
5CDS-5UTR	ENST00000580402	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
5UTR-3CDS	ENST00000487778	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
5UTR-5UTR	ENST00000487778	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
Frame-shift	ENST00000580402	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
In-frame	ENST00000355994	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
In-frame	ENST00000397860	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
In-frame	ENST00000397863	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
In-frame	ENST00000579129	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-3CDS	ENST00000354542	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-3CDS	ENST00000359645	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-3CDS	ENST00000382582	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-3CDS	ENST00000397865	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-3CDS	ENST00000397866	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-3CDS	ENST00000397869	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-3CDS	ENST00000397875	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-3CDS	ENST00000526111	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-3CDS	ENST00000527041	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-3CDS	ENST00000528160	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-3CDS	ENST00000578193	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-5UTR	ENST00000354542	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-5UTR	ENST00000359645	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-5UTR	ENST00000382582	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-5UTR	ENST00000397865	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-5UTR	ENST00000397866	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-5UTR	ENST00000397869	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-5UTR	ENST00000397875	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-5UTR	ENST00000526111	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-5UTR	ENST00000527041	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-5UTR	ENST00000528160	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-
intron-5UTR	ENST00000578193	ENST00000524431	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000355994	MBP	chr18	74817166	-	ENST00000443185	ZNF516	chr18	74092259	-	6806	315	86	1996	636
ENST00000579129	MBP	chr18	74817166	-	ENST00000443185	ZNF516	chr18	74092259	-	6832	341	25	2022	665
ENST00000397863	MBP	chr18	74817166	-	ENST00000443185	ZNF516	chr18	74092259	-	6713	222	71	1903	610
ENST00000397860	MBP	chr18	74817166	-	ENST00000443185	ZNF516	chr18	74092259	-	6757	266	37	1947	636

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000355994	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-	0.00800611	0.9919939
ENST00000579129	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-	0.008105212	0.9918948
ENST00000397863	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-	0.006686912	0.993313
ENST00000397860	ENST00000443185	MBP	chr18	74817166	-	ZNF516	chr18	74092259	-	0.007646033	0.9923539

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Fusion Genomic Features for MBP-ZNF516

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MBP-ZNF516

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:74202637/chr18:74702016)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ZNF516

chr18:74817166

chr18:74092259

ENST00000443185

1098_1120

603

1164.0

Zinc finger

C2H2-type 10

Tgene

ZNF516

chr18:74817166

chr18:74092259

ENST00000443185

760_783

603

1164.0

Zinc finger

C2H2-type 9%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000355994

179_222

305.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000355994

246_256

305.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000359645

179_222

187.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000359645

246_256

187.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000382582

179_222

198.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000382582

246_256

198.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000397860

179_222

198.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000397860

246_256

198.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000397863

179_222

198.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000397863

246_256

198.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000397865

179_222

161.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000397865

246_256

161.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000397866

179_222

172.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000397866

246_256

172.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000580402

179_222

305.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Hgene

MBP

chr18:74817166

chr18:74092259

ENST00000580402

246_256

305.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Tgene

ZNF516

chr18:74817166

chr18:74092259

ENST00000443185

1_431

603

1164.0

Region

Mediates promoter DNA-binding and activation of transcription

Tgene

ZNF516

chr18:74817166

chr18:74092259

ENST00000443185

174_197

603

1164.0

Zinc finger

C2H2-type 3

Tgene

ZNF516

chr18:74817166

chr18:74092259

ENST00000443185

200_223

603

1164.0

Zinc finger

C2H2-type 4

Tgene

ZNF516

chr18:74817166

chr18:74092259

ENST00000443185

248_270

603

1164.0

Zinc finger

C2H2-type 5

Tgene

ZNF516

chr18:74817166

chr18:74092259

ENST00000443185

276_298

603

1164.0

Zinc finger

C2H2-type 6

Tgene

ZNF516

chr18:74817166

chr18:74092259

ENST00000443185

335_357

603

1164.0

Zinc finger

C2H2-type 7

Tgene

ZNF516

chr18:74817166

chr18:74092259

ENST00000443185

34_56

603

1164.0

Zinc finger

C2H2-type 1

Tgene

ZNF516

chr18:74817166

chr18:74092259

ENST00000443185

515_537

603

1164.0

Zinc finger

C2H2-type 8

Tgene

ZNF516

chr18:74817166

chr18:74092259

ENST00000443185

62_84

603

1164.0

Zinc finger

C2H2-type 2

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Fusion Gene Sequence for MBP-ZNF516

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>52091_52091_1_MBP-ZNF516_MBP_chr18_74817166_ENST00000355994_ZNF516_chr18_74092259_ENST00000443185_length(transcript)=6806nt_BP=315nt
TGGGTGCGCGCCCGTCCCTCGGAGCCGCCGCCGTCAGTCACCGCCGCCGCGCGCCAGAGAGAAGCAGCCTCCGGCCCCGGCGGCCCCTGT
CTCCCGACCCCGGAAGGCGAAGCAGGCTGCCCGGGGACCCCGCGCGTGGGCGCTTGAAGCCGAGACCAGCCTGCCCGGGCCTGGGCAGGC
GGAGCAGGGCCTTGGACCCCGCGGCGCCCCTCGGCCTCGGAGCAACGAGCGCAGCGCCGCCTCTGAAGAGCCAATCCATTCAGGATGGGA
AACCACGCAGGCAAACGAGAATTAAATGCCGAGAAGGCCAGTACGGGGGACAGCCGCGCCGCTGCTGCTTTTCCGAAGAGGTGACTTCGA
CCGAGCTCTCCAGTGGAGACCAGAGTCACAAGATGGGAGATAACGCCTCGGAAAGAGACACCGGCGAGTCCAAGGCAGGGATCGCAGCTT
CTGTGTCCATACTTGAAAACAGTAGCAGAGAGACTTCTAGAAGGCAAGAGCAGCACAGATTTTCTATGGACTTAAAGATGCCAGCATTTC
ACCCCAAGCAGGAGGTGCCCGTCCCTGGTGATGGTGTGGAGTTCCCTTCCAGTACGGGAGCGGAGGGCCAGACGGGTCACCCTGCAGAAA
AGCTGTCCGATTTGCACAACAAGGAACACTCTGGGGGAGGGAAGCGGGCGCTGGCCCCAGACCTCATGCCGCTAGATTTAAGTGCGAGGT
CGACGCGGGATGACCCCAGCAATAAGGAGACGGCCTCCTCCCTGCAGGCGGCTTTAGTCGTTCACCCGTGTCCTTACTGCAGCCACAAGA
CCTACTACCCCGAGGTCCTGTGGATGCACAAACGCATCTGGCACCGCGTCAGCTGCAACTCCGTGGCTCCCCCGTGGATTCAGCCCAATG
GTTACAAAAGCATCAGAAGCAATTTGGTTTTCCTTTCCCGGAGCGGACGCACGGGCCCCCCGCCTGCCCTCGGTGGCAAAGAATGCCAGC
CTTTGCTCCTTGCTCGGTTCACCCGCACTCAGGTGCCAGGGGGGATGCCGGGGTCCAAAAGTGGCTCTTCTCCCCTGGGAGTGGTCACAA
AAGCCGCTAGCATGCCTAAGAATAAGGAGAGCCATTCCGGAGGTCCCTGCGCTCTGTGGGCGCCCGGCCCTGACGGGTATCGACAGACCA
AACCTTGTCACGGCCAGGAGCCACATGGCGCGGCCACACAGGGGCCCCTGGCCAAGCCCAGGCAGGAGGCTAGCTCCAAACCGGTGCCTG
CCCCGGGTGGCGGGGGCTTCAGCAGGAGCGCCACCCCTACGCCCACCGTCATCGCCCGGGCTGGCGCGCAGCCCTCGGCCAATAGCAAGC
CTGTGGAGAAGTTTGGGGTCCCCCCAGCGGGGGCTGGCTTTGCCCCCACAAATAAGCACAGTGCCCCGGACTCCCTGAAAGCCAAATTCA
GTGCTCAGCCTCAGGGTCCACCTCCTGCAAAGGGCGAAGGGGGCGCTCCTCCTCTACCTCCCCGCGAGCCCCCCTCGAAGGCAGCCCAGG
AGCTGAGGACTCTGGCCACCTGTGCTGCGGGGTCCAGGGGCGACGCGGCCTTGCAGGCCCAGCCCGGCGTGGCTGGGGCGCCCCCCGTCC
TACACTCCATCAAACAGGAGCCGGTGGCCGAGGGGCATGAGAAGCGCCTGGACATCCTCAACATCTTTAAGACGTACATTCCAAAGGACT
TTGCGACCCTCTACCAGGGATGGGGTGTCAGCGGCCCTGGGTTGGAGCACAGAGGGACACTCCGGACGCAGGCCCGGCCAGGAGAGTTCG
TCTGCATCGAGTGCGGAAAGAGCTTCCACCAGCCCGGCCACCTCAGGGCCCACATGCGGGCACACTCAGTGGTGTTTGAGTCCGATGGGC
CTCGGGGTTCTGAAGTTCATACCACCTCCGCAGACGCCCCCAAACAAGGGAGAGACCATTCTAACACAGGTACCGTCCAGACAGTGCCTC
TGAGAAAGGGAACCTAAAGGCGTGTTTCCGACGCACCCCAGGTCCCCGTAACGGCCATTAGCAGTACCCTCACGATGTCCCAGCAGCCTC
CCACCTGTGACCTGGCCGCTCCATGGAAGAACAGCCGGGGAACTCCTGAGCAGACACCTCACATCCCGAGCCGCTGCGCTGGAGTGGAAA
CTGAAGGCAGATGCCTCTCCTTGTTAAACGTTCAGAAATAAATGAAGATGCTATATTCTAGAAATACATGTAGATACTATATACGCATTT
ACGTGCTCATCGTCCATAGTCCCATATTTTCTTATAATAAACAGTAGTACTGGCAGGCACAGTAGGGGCACAAGGCATCTGTCTTATTCA
AGACAAGTTTGAGACACTGGAAAAAAAGATACTTGTTGTGTGTGTTGGACAGAGTGGCGAGGCTGAGCACTGTCACAGGGGCCTCCCATG
TTAAGAGGGACTGTGGGGATGATGTCAGAACAAGACGTGGTGGATTTGAGGTTGATCGAGTATTAATACTACTGCCTCTCCTTGTCTTAG
TGGGTATTTAAAATAGTAAATAAGAGAGAGGAAGGAGGTGACGTTCAGGTGCTGTGGGAAGCAGGCTTGGCGGAGGGGTATGATGATGAG
ACCCTCATTGTTCACTGGCTCCATCGCACTCCTCCCTGGGGCCGTGTGCCTGTTCCATTCTTCCCACCATTCGAACTGAGCGAATCTGGC
AAAGGAGACACGTCTGTGGGAATGCGTAGATTCCGCCTCGGAAGAGAGCTAGCGCAACACTAAGAAAAGCAGGCTTCTTGTTTATTCTCA
GGACCTTTTTGTAACAGGGCTACATTCTGCAAACTGCTTACAAAGGAAGACTATACGTCTTAACAAATTATTTAGCCACTGAGTCCTCCC
GATTCGGACCTGTTTTAGTAATGGCAGAAGAATCCCTGAGCAGGTTCAGGTGCCCTAGATGACTAGGGTGCTGAGCTCTGGCGCCTTCTG
TCCCCACTCTTTGCCTCCCCGCCCCTTCCCTGAGCCACCCCAGCAAGTGGGTGTCTTTTCTCCCTGGGCCTGGTGACCTCCACAGGATGA
GTGACTTTGTTCATAAAGGGTGGGGATCACCAGCCCCTTGGGTGGGGGACGGCTTCATATACCTCTTCCTCAGTAATGCAAATGCGAGTT
TTTGTGGTGGGGGTTAAGGCCCATAACAAAGGATCTTAAACCATGCAGTGTACGCAATTGAAATGGTATTCCACAGATATAAATATTTTC
TTTTCCCATTGCCGTGACACTATGTGTGATGGTAATATTTCTGAGAGTTTCAGATTTTTGCACATATGATTTTATGCATTATCAAAAGTT
ACTGCTGCCTTGAATGAAAATGTTCTGTGAAATTTTTTGCAAAAGCTTTACTAGGTTTTTTTTTAATTGTGAAATTTTGTAAAGGCAGGA
AATGGATTAAAACGAGCATGCTAAATATATTTTTCAAAAAAGCAATAATTTTACATGTACAGAAATTATCCTAACCTTTAATACTGGCGA
GAGCAACAGTTTACTTAATACGGTAATGGACTAGTGCAGTTTTTGTAGACAGTGGGCTTCTGATACAAAGTCTTGTTTAAACACAGACAC
ACACACACACAAACACACACACACACCCTAAAGTGTGGGTTTCCTGTTCTAATGATTTGTTGAATATTATTATATTATTATTATTATTAT
TATTATTATTGTTATTGTTATTAGTAATGTTTGGTTCTGGATTCTACTTGTTACTGAGTTTAAATTACTTGACGGTTCAGGTTACTTTGC
AACACTTTCAAACGATGCAATGTAACTGGCTAGCTTATATATATATATATATATATATATATATATATTTTTTTTTTTTTTTACTTATTT
TTTTCTGATATTCTTACACCAGATATGTACGAAAATGATCTGTCCTGTTGGTGTAATTAGGAATGTCCATGCAGATACAGTTAAACAACT
GTAATTGACTGTTCTGTAAAGTTATTTTGGGCAAAGTTGCGGAGACACATTCCTCTGTCCACCTAAGAAATCAGAAGACTCTTCTGTTGA
TTTATGTTTAATCATTTCAGTAGTTTCCCCACAGTGATCATTTCTGCATTTTCTGGCTTTTGTTTTCTTGGCTGAAAGTGAATGGTGACT
GTTAGGAATGTCAGGGACTAGTGACCCAGTCCTGTTTCTCTGTGTTTTAGTTATTAAAAAGAAATTCTGTACCCAAAGTGACACGAAAGT
GTAGTCTACATTTTTACTGTTTCAGAAGCGGCATGGAAAAGTGCAGTTGGCCTTTGGAGCTGGAAGTGTCTTGCTGGTGAGGCTCCATCC
TGGAGGCTCTGGTGGGGAGTGGGCTGGCGCTGGGGCCCTGCCGGCCGCGTGCTGGATCCTTCCTGGCTTGCAGGAGAGCAGGCGTGGAGG
ACAGTCAGCTTGCGGGGCCGCGCAGGGTGCACAGAGTGCAGGAGGAAGGTTTTCACCCAGTTAAACAGACTGGGGAGCCCCCCCAAGAAC
GCCATCCCTTGAGGCCAGCTGTGGGCAGGCCTGGATGTGTGGTCCCTTCCTTCCACCCATCGTCAGTATTGTGTTGGTTTGTTAATTTGT
TGATTTGGTCATAGTATTTAATATGATTTGTGTTTCCTTATTTATTTAGCCACCGTTTTGATTGCCTTTTTTTTTCCGAATGGTAATTTC
TGCATGATACACTTCTGTACGTTGTCTTCTGACTGTTACAGACTTTCTACTACCTCTCCCGATCTGCTGTTTCCTTGTTTCTTAACAGGA
TTTTTTACAGTGTTGCGTCTAATGTAACTTAGACAATAAAGGGTTTGGTTGTCTACACTGCAGCTTCTCGGTGTCTCTCCCCTGCTTTCC
GCTCGCTGCTTCCCGCTCTGCCCCTGCTGGGGCCTGGCTGCACCCTGGCCTGCCTTCCTATACTCTCCTGTTTCCTGCTCATATCTCTTC
CTCATTTTTGCGTTCAAATAACACACAGCTAATGAGCTTCTAAAAATCTTTTCAGGTTGTTCACTTGTATTCCTTAATTTGAAGAATGAA
TATTTAAATTCTCTCAAAAGTCAGATATTGAGGATCTTCTCTGGGAAATTGGCCACTGTACCTGCCCACCTTTCTGCCTGGTTCCCTGGA
AGGTCTTATTGTCATCTTAGACGGACAGATTTCATTCTCAGCACCATACAGATTTGGCTTCAAAGCCAGGTGAATTTTGCCTTTGAGGCT
CTGAAAAGTATTAAGTGTTTTAAGAGGTCCCCCAATATTTACTTATTTATTTTTTAAACCAAGAAAGACACTGGTTCCCTGAAAAGCAGG
TGCTTCAGGAAGTAGCAATTGGGAGTTGCATACAGTTACTTCGTCAGAGAAAGGAGCGCCCAGTATGACAGGCCCCCACCCCTGATCCGG
CCACTGTGCACAGGTCGCTGAGGGTGTGAGAACACCTCTGCAGGGGCTCCGGCACATGTGGGTTTCATCGTCTCACACTCCTTCAGGCTG
CAGGGGTTGAGTGCAGAAAGGGCAAGCTTCATCTCCATGGTGCCTCTCCAGGCTGGCAACTCTGGTCGGCCTCTGTTCTTTGGACAGAGA
GGGTGTAGGTTACAGGGTCAGTAGGGATGCTTTCTGGATCAAAGAAAGTGGGTGTAGTGCTTAGTCTGTTGTGTGGAAGAGGGCACCTCC
TGGGCTTTCGTGGCTGGAGACTGTCTACCAACATTCCTTCCTTCAAACTAGACAAACCCTCCTCTGCCACCCCCAGCAAATTCTCAGAGG
TTTCCAAGCTGTAGAAAAAGGAAGGAAGGAAGGACGGCATTCACATAGCTTTACTTTCTGCTTCAAAATGTCTTAAGTAGCATATGTTGT
TTTACTGCTTTTAACTTTGGTGAGTTCTAATTTCAGAACGTTTTGTTCACTGAGCAAAAAAACAGATGAAACAACCACAGGCCAGGACTT
CAAGTGAGGAGGACGCCTTTGTTTGCCGTGGTTGGTGGGAGCACACGCCGGAGCCCGGTAACGTGCCTGTGGGAGTGACCAAGGGCCACC
CGCCCAAGGGAAAATGTTCATTCTTCATCAGCTTTGCTAATTCTGCTTTGAGGCAGTAAAATGCAAAAGACCATAGAATTTGTATTTCTT
TTTTTAAAATACAATTTATAACATTATATTTTGTACTCTTTATATTAGAATTTGTAACTAGATTGATGTATTTAACTATTTCTGAAAAAG
TAATTCAATGTTTTAGTTGTGTGATAAAAATATTTAGATAAAACATATTCATTCTATTGGAATTTGAAATAAATAAAAACATCTTGGAGT
TCTGAGATTTGTAAGACATTTTTCCCCAATTTCAGAGGGTGGCGTAAATCGTTTGACAGCCCGCTTTGGTCTGTGGTTATTTATTTTTGT
TGGCTGAACATAAACCAAAGTGTTAATGCTCTTTATTTATGGAAGAGTTTTAGGGTAATTCACAAGATCGTTCATCTGAACAGATGCCCA
GATGGCCCGAGTGGTTTTTTTCCAACTCTTTTGTGGACTCGAGGACATACAGTTTTTTAATGGAGACGCTGTGTTTTTCTCATTTTCTTT
CACAGCACACATGTTATTTCCCCACTGAATACACCCACTGTTCTTACCCTTGCACTGTCACCCATACAGGACGCACAGGGATGGACGCGG
ACGGAATTCTGACTCAGCCACACCTGGAGGAAATTATTGTGTCAAAAATGTGGGGACACAAGGGCTGGCACTGTGGTTTGCAATGGTTTA

>52091_52091_1_MBP-ZNF516_MBP_chr18_74817166_ENST00000355994_ZNF516_chr18_74092259_ENST00000443185_length(amino acids)=636AA_BP=1
MSPDPGRRSRLPGDPARGRLKPRPACPGLGRRSRALDPAAPLGLGATSAAPPLKSQSIQDGKPRRQTRIKCREGQYGGQPRRCCFSEEVT
STELSSGDQSHKMGDNASERDTGESKAGIAASVSILENSSRETSRRQEQHRFSMDLKMPAFHPKQEVPVPGDGVEFPSSTGAEGQTGHPA
EKLSDLHNKEHSGGGKRALAPDLMPLDLSARSTRDDPSNKETASSLQAALVVHPCPYCSHKTYYPEVLWMHKRIWHRVSCNSVAPPWIQP
NGYKSIRSNLVFLSRSGRTGPPPALGGKECQPLLLARFTRTQVPGGMPGSKSGSSPLGVVTKAASMPKNKESHSGGPCALWAPGPDGYRQ
TKPCHGQEPHGAATQGPLAKPRQEASSKPVPAPGGGGFSRSATPTPTVIARAGAQPSANSKPVEKFGVPPAGAGFAPTNKHSAPDSLKAK
FSAQPQGPPPAKGEGGAPPLPPREPPSKAAQELRTLATCAAGSRGDAALQAQPGVAGAPPVLHSIKQEPVAEGHEKRLDILNIFKTYIPK
DFATLYQGWGVSGPGLEHRGTLRTQARPGEFVCIECGKSFHQPGHLRAHMRAHSVVFESDGPRGSEVHTTSADAPKQGRDHSNTGTVQTV

--------------------------------------------------------------
>52091_52091_2_MBP-ZNF516_MBP_chr18_74817166_ENST00000397860_ZNF516_chr18_74092259_ENST00000443185_length(transcript)=6757nt_BP=266nt
CGCGCCAGAGAGAAGCAGCCTCCGGCCCCGGCGGCCCCTGTCTCCCGACCCCGGAAGGCGAAGCAGGCTGCCCGGGGACCCCGCGCGTGG
GCGCTTGAAGCCGAGACCAGCCTGCCCGGGCCTGGGCAGGCGGAGCAGGGCCTTGGACCCCGCGGCGCCCCTCGGCCTCGGAGCAACGAG
CGCAGCGCCGCCTCTGAAGAGCCAATCCATTCAGGATGGGAAACCACGCAGGCAAACGAGAATTAAATGCCGAGAAGGCCAGTACGGGGG
ACAGCCGCGCCGCTGCTGCTTTTCCGAAGAGGTGACTTCGACCGAGCTCTCCAGTGGAGACCAGAGTCACAAGATGGGAGATAACGCCTC
GGAAAGAGACACCGGCGAGTCCAAGGCAGGGATCGCAGCTTCTGTGTCCATACTTGAAAACAGTAGCAGAGAGACTTCTAGAAGGCAAGA
GCAGCACAGATTTTCTATGGACTTAAAGATGCCAGCATTTCACCCCAAGCAGGAGGTGCCCGTCCCTGGTGATGGTGTGGAGTTCCCTTC
CAGTACGGGAGCGGAGGGCCAGACGGGTCACCCTGCAGAAAAGCTGTCCGATTTGCACAACAAGGAACACTCTGGGGGAGGGAAGCGGGC
GCTGGCCCCAGACCTCATGCCGCTAGATTTAAGTGCGAGGTCGACGCGGGATGACCCCAGCAATAAGGAGACGGCCTCCTCCCTGCAGGC
GGCTTTAGTCGTTCACCCGTGTCCTTACTGCAGCCACAAGACCTACTACCCCGAGGTCCTGTGGATGCACAAACGCATCTGGCACCGCGT
CAGCTGCAACTCCGTGGCTCCCCCGTGGATTCAGCCCAATGGTTACAAAAGCATCAGAAGCAATTTGGTTTTCCTTTCCCGGAGCGGACG
CACGGGCCCCCCGCCTGCCCTCGGTGGCAAAGAATGCCAGCCTTTGCTCCTTGCTCGGTTCACCCGCACTCAGGTGCCAGGGGGGATGCC
GGGGTCCAAAAGTGGCTCTTCTCCCCTGGGAGTGGTCACAAAAGCCGCTAGCATGCCTAAGAATAAGGAGAGCCATTCCGGAGGTCCCTG
CGCTCTGTGGGCGCCCGGCCCTGACGGGTATCGACAGACCAAACCTTGTCACGGCCAGGAGCCACATGGCGCGGCCACACAGGGGCCCCT
GGCCAAGCCCAGGCAGGAGGCTAGCTCCAAACCGGTGCCTGCCCCGGGTGGCGGGGGCTTCAGCAGGAGCGCCACCCCTACGCCCACCGT
CATCGCCCGGGCTGGCGCGCAGCCCTCGGCCAATAGCAAGCCTGTGGAGAAGTTTGGGGTCCCCCCAGCGGGGGCTGGCTTTGCCCCCAC
AAATAAGCACAGTGCCCCGGACTCCCTGAAAGCCAAATTCAGTGCTCAGCCTCAGGGTCCACCTCCTGCAAAGGGCGAAGGGGGCGCTCC
TCCTCTACCTCCCCGCGAGCCCCCCTCGAAGGCAGCCCAGGAGCTGAGGACTCTGGCCACCTGTGCTGCGGGGTCCAGGGGCGACGCGGC
CTTGCAGGCCCAGCCCGGCGTGGCTGGGGCGCCCCCCGTCCTACACTCCATCAAACAGGAGCCGGTGGCCGAGGGGCATGAGAAGCGCCT
GGACATCCTCAACATCTTTAAGACGTACATTCCAAAGGACTTTGCGACCCTCTACCAGGGATGGGGTGTCAGCGGCCCTGGGTTGGAGCA
CAGAGGGACACTCCGGACGCAGGCCCGGCCAGGAGAGTTCGTCTGCATCGAGTGCGGAAAGAGCTTCCACCAGCCCGGCCACCTCAGGGC
CCACATGCGGGCACACTCAGTGGTGTTTGAGTCCGATGGGCCTCGGGGTTCTGAAGTTCATACCACCTCCGCAGACGCCCCCAAACAAGG
GAGAGACCATTCTAACACAGGTACCGTCCAGACAGTGCCTCTGAGAAAGGGAACCTAAAGGCGTGTTTCCGACGCACCCCAGGTCCCCGT
AACGGCCATTAGCAGTACCCTCACGATGTCCCAGCAGCCTCCCACCTGTGACCTGGCCGCTCCATGGAAGAACAGCCGGGGAACTCCTGA
GCAGACACCTCACATCCCGAGCCGCTGCGCTGGAGTGGAAACTGAAGGCAGATGCCTCTCCTTGTTAAACGTTCAGAAATAAATGAAGAT
GCTATATTCTAGAAATACATGTAGATACTATATACGCATTTACGTGCTCATCGTCCATAGTCCCATATTTTCTTATAATAAACAGTAGTA
CTGGCAGGCACAGTAGGGGCACAAGGCATCTGTCTTATTCAAGACAAGTTTGAGACACTGGAAAAAAAGATACTTGTTGTGTGTGTTGGA
CAGAGTGGCGAGGCTGAGCACTGTCACAGGGGCCTCCCATGTTAAGAGGGACTGTGGGGATGATGTCAGAACAAGACGTGGTGGATTTGA
GGTTGATCGAGTATTAATACTACTGCCTCTCCTTGTCTTAGTGGGTATTTAAAATAGTAAATAAGAGAGAGGAAGGAGGTGACGTTCAGG
TGCTGTGGGAAGCAGGCTTGGCGGAGGGGTATGATGATGAGACCCTCATTGTTCACTGGCTCCATCGCACTCCTCCCTGGGGCCGTGTGC
CTGTTCCATTCTTCCCACCATTCGAACTGAGCGAATCTGGCAAAGGAGACACGTCTGTGGGAATGCGTAGATTCCGCCTCGGAAGAGAGC
TAGCGCAACACTAAGAAAAGCAGGCTTCTTGTTTATTCTCAGGACCTTTTTGTAACAGGGCTACATTCTGCAAACTGCTTACAAAGGAAG
ACTATACGTCTTAACAAATTATTTAGCCACTGAGTCCTCCCGATTCGGACCTGTTTTAGTAATGGCAGAAGAATCCCTGAGCAGGTTCAG
GTGCCCTAGATGACTAGGGTGCTGAGCTCTGGCGCCTTCTGTCCCCACTCTTTGCCTCCCCGCCCCTTCCCTGAGCCACCCCAGCAAGTG
GGTGTCTTTTCTCCCTGGGCCTGGTGACCTCCACAGGATGAGTGACTTTGTTCATAAAGGGTGGGGATCACCAGCCCCTTGGGTGGGGGA
CGGCTTCATATACCTCTTCCTCAGTAATGCAAATGCGAGTTTTTGTGGTGGGGGTTAAGGCCCATAACAAAGGATCTTAAACCATGCAGT
GTACGCAATTGAAATGGTATTCCACAGATATAAATATTTTCTTTTCCCATTGCCGTGACACTATGTGTGATGGTAATATTTCTGAGAGTT
TCAGATTTTTGCACATATGATTTTATGCATTATCAAAAGTTACTGCTGCCTTGAATGAAAATGTTCTGTGAAATTTTTTGCAAAAGCTTT
ACTAGGTTTTTTTTTAATTGTGAAATTTTGTAAAGGCAGGAAATGGATTAAAACGAGCATGCTAAATATATTTTTCAAAAAAGCAATAAT
TTTACATGTACAGAAATTATCCTAACCTTTAATACTGGCGAGAGCAACAGTTTACTTAATACGGTAATGGACTAGTGCAGTTTTTGTAGA
CAGTGGGCTTCTGATACAAAGTCTTGTTTAAACACAGACACACACACACACAAACACACACACACACCCTAAAGTGTGGGTTTCCTGTTC
TAATGATTTGTTGAATATTATTATATTATTATTATTATTATTATTATTATTGTTATTGTTATTAGTAATGTTTGGTTCTGGATTCTACTT
GTTACTGAGTTTAAATTACTTGACGGTTCAGGTTACTTTGCAACACTTTCAAACGATGCAATGTAACTGGCTAGCTTATATATATATATA
TATATATATATATATATATTTTTTTTTTTTTTTACTTATTTTTTTCTGATATTCTTACACCAGATATGTACGAAAATGATCTGTCCTGTT
GGTGTAATTAGGAATGTCCATGCAGATACAGTTAAACAACTGTAATTGACTGTTCTGTAAAGTTATTTTGGGCAAAGTTGCGGAGACACA
TTCCTCTGTCCACCTAAGAAATCAGAAGACTCTTCTGTTGATTTATGTTTAATCATTTCAGTAGTTTCCCCACAGTGATCATTTCTGCAT
TTTCTGGCTTTTGTTTTCTTGGCTGAAAGTGAATGGTGACTGTTAGGAATGTCAGGGACTAGTGACCCAGTCCTGTTTCTCTGTGTTTTA
GTTATTAAAAAGAAATTCTGTACCCAAAGTGACACGAAAGTGTAGTCTACATTTTTACTGTTTCAGAAGCGGCATGGAAAAGTGCAGTTG
GCCTTTGGAGCTGGAAGTGTCTTGCTGGTGAGGCTCCATCCTGGAGGCTCTGGTGGGGAGTGGGCTGGCGCTGGGGCCCTGCCGGCCGCG
TGCTGGATCCTTCCTGGCTTGCAGGAGAGCAGGCGTGGAGGACAGTCAGCTTGCGGGGCCGCGCAGGGTGCACAGAGTGCAGGAGGAAGG
TTTTCACCCAGTTAAACAGACTGGGGAGCCCCCCCAAGAACGCCATCCCTTGAGGCCAGCTGTGGGCAGGCCTGGATGTGTGGTCCCTTC
CTTCCACCCATCGTCAGTATTGTGTTGGTTTGTTAATTTGTTGATTTGGTCATAGTATTTAATATGATTTGTGTTTCCTTATTTATTTAG
CCACCGTTTTGATTGCCTTTTTTTTTCCGAATGGTAATTTCTGCATGATACACTTCTGTACGTTGTCTTCTGACTGTTACAGACTTTCTA
CTACCTCTCCCGATCTGCTGTTTCCTTGTTTCTTAACAGGATTTTTTACAGTGTTGCGTCTAATGTAACTTAGACAATAAAGGGTTTGGT
TGTCTACACTGCAGCTTCTCGGTGTCTCTCCCCTGCTTTCCGCTCGCTGCTTCCCGCTCTGCCCCTGCTGGGGCCTGGCTGCACCCTGGC
CTGCCTTCCTATACTCTCCTGTTTCCTGCTCATATCTCTTCCTCATTTTTGCGTTCAAATAACACACAGCTAATGAGCTTCTAAAAATCT
TTTCAGGTTGTTCACTTGTATTCCTTAATTTGAAGAATGAATATTTAAATTCTCTCAAAAGTCAGATATTGAGGATCTTCTCTGGGAAAT
TGGCCACTGTACCTGCCCACCTTTCTGCCTGGTTCCCTGGAAGGTCTTATTGTCATCTTAGACGGACAGATTTCATTCTCAGCACCATAC
AGATTTGGCTTCAAAGCCAGGTGAATTTTGCCTTTGAGGCTCTGAAAAGTATTAAGTGTTTTAAGAGGTCCCCCAATATTTACTTATTTA
TTTTTTAAACCAAGAAAGACACTGGTTCCCTGAAAAGCAGGTGCTTCAGGAAGTAGCAATTGGGAGTTGCATACAGTTACTTCGTCAGAG
AAAGGAGCGCCCAGTATGACAGGCCCCCACCCCTGATCCGGCCACTGTGCACAGGTCGCTGAGGGTGTGAGAACACCTCTGCAGGGGCTC
CGGCACATGTGGGTTTCATCGTCTCACACTCCTTCAGGCTGCAGGGGTTGAGTGCAGAAAGGGCAAGCTTCATCTCCATGGTGCCTCTCC
AGGCTGGCAACTCTGGTCGGCCTCTGTTCTTTGGACAGAGAGGGTGTAGGTTACAGGGTCAGTAGGGATGCTTTCTGGATCAAAGAAAGT
GGGTGTAGTGCTTAGTCTGTTGTGTGGAAGAGGGCACCTCCTGGGCTTTCGTGGCTGGAGACTGTCTACCAACATTCCTTCCTTCAAACT
AGACAAACCCTCCTCTGCCACCCCCAGCAAATTCTCAGAGGTTTCCAAGCTGTAGAAAAAGGAAGGAAGGAAGGACGGCATTCACATAGC
TTTACTTTCTGCTTCAAAATGTCTTAAGTAGCATATGTTGTTTTACTGCTTTTAACTTTGGTGAGTTCTAATTTCAGAACGTTTTGTTCA
CTGAGCAAAAAAACAGATGAAACAACCACAGGCCAGGACTTCAAGTGAGGAGGACGCCTTTGTTTGCCGTGGTTGGTGGGAGCACACGCC
GGAGCCCGGTAACGTGCCTGTGGGAGTGACCAAGGGCCACCCGCCCAAGGGAAAATGTTCATTCTTCATCAGCTTTGCTAATTCTGCTTT
GAGGCAGTAAAATGCAAAAGACCATAGAATTTGTATTTCTTTTTTTAAAATACAATTTATAACATTATATTTTGTACTCTTTATATTAGA
ATTTGTAACTAGATTGATGTATTTAACTATTTCTGAAAAAGTAATTCAATGTTTTAGTTGTGTGATAAAAATATTTAGATAAAACATATT
CATTCTATTGGAATTTGAAATAAATAAAAACATCTTGGAGTTCTGAGATTTGTAAGACATTTTTCCCCAATTTCAGAGGGTGGCGTAAAT
CGTTTGACAGCCCGCTTTGGTCTGTGGTTATTTATTTTTGTTGGCTGAACATAAACCAAAGTGTTAATGCTCTTTATTTATGGAAGAGTT
TTAGGGTAATTCACAAGATCGTTCATCTGAACAGATGCCCAGATGGCCCGAGTGGTTTTTTTCCAACTCTTTTGTGGACTCGAGGACATA
CAGTTTTTTAATGGAGACGCTGTGTTTTTCTCATTTTCTTTCACAGCACACATGTTATTTCCCCACTGAATACACCCACTGTTCTTACCC
TTGCACTGTCACCCATACAGGACGCACAGGGATGGACGCGGACGGAATTCTGACTCAGCCACACCTGGAGGAAATTATTGTGTCAAAAAT
GTGGGGACACAAGGGCTGGCACTGTGGTTTGCAATGGTTTACTGATGAGACAGCAAAAATGAGACAGGACCATCAGATGCAATAAAGATT

>52091_52091_2_MBP-ZNF516_MBP_chr18_74817166_ENST00000397860_ZNF516_chr18_74092259_ENST00000443185_length(amino acids)=636AA_BP=1
MSPDPGRRSRLPGDPARGRLKPRPACPGLGRRSRALDPAAPLGLGATSAAPPLKSQSIQDGKPRRQTRIKCREGQYGGQPRRCCFSEEVT
STELSSGDQSHKMGDNASERDTGESKAGIAASVSILENSSRETSRRQEQHRFSMDLKMPAFHPKQEVPVPGDGVEFPSSTGAEGQTGHPA
EKLSDLHNKEHSGGGKRALAPDLMPLDLSARSTRDDPSNKETASSLQAALVVHPCPYCSHKTYYPEVLWMHKRIWHRVSCNSVAPPWIQP
NGYKSIRSNLVFLSRSGRTGPPPALGGKECQPLLLARFTRTQVPGGMPGSKSGSSPLGVVTKAASMPKNKESHSGGPCALWAPGPDGYRQ
TKPCHGQEPHGAATQGPLAKPRQEASSKPVPAPGGGGFSRSATPTPTVIARAGAQPSANSKPVEKFGVPPAGAGFAPTNKHSAPDSLKAK
FSAQPQGPPPAKGEGGAPPLPPREPPSKAAQELRTLATCAAGSRGDAALQAQPGVAGAPPVLHSIKQEPVAEGHEKRLDILNIFKTYIPK
DFATLYQGWGVSGPGLEHRGTLRTQARPGEFVCIECGKSFHQPGHLRAHMRAHSVVFESDGPRGSEVHTTSADAPKQGRDHSNTGTVQTV

--------------------------------------------------------------
>52091_52091_3_MBP-ZNF516_MBP_chr18_74817166_ENST00000397863_ZNF516_chr18_74092259_ENST00000443185_length(transcript)=6713nt_BP=222nt
TCCTTTCGCGTCCACCTGAGCCCCCCCGTTTTGGAAGGTGGAGTGGGGCTTGGGAAAAGGTTCAAGCGTCTTTGGGGACCCCCGTGCGAC
TCTGGCTGGAAACAGGCGAGCTCTGGTTCCTTGTTCCGTTTTCCAATTGCAACAACCCTCTGAAGAGCCAATCCATTCAGGATGGGAAAC
CACGCAGGCAAACGAGAATTAAATGCCGAGAAGGCCAGTACGGGGGACAGCCGCGCCGCTGCTGCTTTTCCGAAGAGGTGACTTCGACCG
AGCTCTCCAGTGGAGACCAGAGTCACAAGATGGGAGATAACGCCTCGGAAAGAGACACCGGCGAGTCCAAGGCAGGGATCGCAGCTTCTG
TGTCCATACTTGAAAACAGTAGCAGAGAGACTTCTAGAAGGCAAGAGCAGCACAGATTTTCTATGGACTTAAAGATGCCAGCATTTCACC
CCAAGCAGGAGGTGCCCGTCCCTGGTGATGGTGTGGAGTTCCCTTCCAGTACGGGAGCGGAGGGCCAGACGGGTCACCCTGCAGAAAAGC
TGTCCGATTTGCACAACAAGGAACACTCTGGGGGAGGGAAGCGGGCGCTGGCCCCAGACCTCATGCCGCTAGATTTAAGTGCGAGGTCGA
CGCGGGATGACCCCAGCAATAAGGAGACGGCCTCCTCCCTGCAGGCGGCTTTAGTCGTTCACCCGTGTCCTTACTGCAGCCACAAGACCT
ACTACCCCGAGGTCCTGTGGATGCACAAACGCATCTGGCACCGCGTCAGCTGCAACTCCGTGGCTCCCCCGTGGATTCAGCCCAATGGTT
ACAAAAGCATCAGAAGCAATTTGGTTTTCCTTTCCCGGAGCGGACGCACGGGCCCCCCGCCTGCCCTCGGTGGCAAAGAATGCCAGCCTT
TGCTCCTTGCTCGGTTCACCCGCACTCAGGTGCCAGGGGGGATGCCGGGGTCCAAAAGTGGCTCTTCTCCCCTGGGAGTGGTCACAAAAG
CCGCTAGCATGCCTAAGAATAAGGAGAGCCATTCCGGAGGTCCCTGCGCTCTGTGGGCGCCCGGCCCTGACGGGTATCGACAGACCAAAC
CTTGTCACGGCCAGGAGCCACATGGCGCGGCCACACAGGGGCCCCTGGCCAAGCCCAGGCAGGAGGCTAGCTCCAAACCGGTGCCTGCCC
CGGGTGGCGGGGGCTTCAGCAGGAGCGCCACCCCTACGCCCACCGTCATCGCCCGGGCTGGCGCGCAGCCCTCGGCCAATAGCAAGCCTG
TGGAGAAGTTTGGGGTCCCCCCAGCGGGGGCTGGCTTTGCCCCCACAAATAAGCACAGTGCCCCGGACTCCCTGAAAGCCAAATTCAGTG
CTCAGCCTCAGGGTCCACCTCCTGCAAAGGGCGAAGGGGGCGCTCCTCCTCTACCTCCCCGCGAGCCCCCCTCGAAGGCAGCCCAGGAGC
TGAGGACTCTGGCCACCTGTGCTGCGGGGTCCAGGGGCGACGCGGCCTTGCAGGCCCAGCCCGGCGTGGCTGGGGCGCCCCCCGTCCTAC
ACTCCATCAAACAGGAGCCGGTGGCCGAGGGGCATGAGAAGCGCCTGGACATCCTCAACATCTTTAAGACGTACATTCCAAAGGACTTTG
CGACCCTCTACCAGGGATGGGGTGTCAGCGGCCCTGGGTTGGAGCACAGAGGGACACTCCGGACGCAGGCCCGGCCAGGAGAGTTCGTCT
GCATCGAGTGCGGAAAGAGCTTCCACCAGCCCGGCCACCTCAGGGCCCACATGCGGGCACACTCAGTGGTGTTTGAGTCCGATGGGCCTC
GGGGTTCTGAAGTTCATACCACCTCCGCAGACGCCCCCAAACAAGGGAGAGACCATTCTAACACAGGTACCGTCCAGACAGTGCCTCTGA
GAAAGGGAACCTAAAGGCGTGTTTCCGACGCACCCCAGGTCCCCGTAACGGCCATTAGCAGTACCCTCACGATGTCCCAGCAGCCTCCCA
CCTGTGACCTGGCCGCTCCATGGAAGAACAGCCGGGGAACTCCTGAGCAGACACCTCACATCCCGAGCCGCTGCGCTGGAGTGGAAACTG
AAGGCAGATGCCTCTCCTTGTTAAACGTTCAGAAATAAATGAAGATGCTATATTCTAGAAATACATGTAGATACTATATACGCATTTACG
TGCTCATCGTCCATAGTCCCATATTTTCTTATAATAAACAGTAGTACTGGCAGGCACAGTAGGGGCACAAGGCATCTGTCTTATTCAAGA
CAAGTTTGAGACACTGGAAAAAAAGATACTTGTTGTGTGTGTTGGACAGAGTGGCGAGGCTGAGCACTGTCACAGGGGCCTCCCATGTTA
AGAGGGACTGTGGGGATGATGTCAGAACAAGACGTGGTGGATTTGAGGTTGATCGAGTATTAATACTACTGCCTCTCCTTGTCTTAGTGG
GTATTTAAAATAGTAAATAAGAGAGAGGAAGGAGGTGACGTTCAGGTGCTGTGGGAAGCAGGCTTGGCGGAGGGGTATGATGATGAGACC
CTCATTGTTCACTGGCTCCATCGCACTCCTCCCTGGGGCCGTGTGCCTGTTCCATTCTTCCCACCATTCGAACTGAGCGAATCTGGCAAA
GGAGACACGTCTGTGGGAATGCGTAGATTCCGCCTCGGAAGAGAGCTAGCGCAACACTAAGAAAAGCAGGCTTCTTGTTTATTCTCAGGA
CCTTTTTGTAACAGGGCTACATTCTGCAAACTGCTTACAAAGGAAGACTATACGTCTTAACAAATTATTTAGCCACTGAGTCCTCCCGAT
TCGGACCTGTTTTAGTAATGGCAGAAGAATCCCTGAGCAGGTTCAGGTGCCCTAGATGACTAGGGTGCTGAGCTCTGGCGCCTTCTGTCC
CCACTCTTTGCCTCCCCGCCCCTTCCCTGAGCCACCCCAGCAAGTGGGTGTCTTTTCTCCCTGGGCCTGGTGACCTCCACAGGATGAGTG
ACTTTGTTCATAAAGGGTGGGGATCACCAGCCCCTTGGGTGGGGGACGGCTTCATATACCTCTTCCTCAGTAATGCAAATGCGAGTTTTT
GTGGTGGGGGTTAAGGCCCATAACAAAGGATCTTAAACCATGCAGTGTACGCAATTGAAATGGTATTCCACAGATATAAATATTTTCTTT
TCCCATTGCCGTGACACTATGTGTGATGGTAATATTTCTGAGAGTTTCAGATTTTTGCACATATGATTTTATGCATTATCAAAAGTTACT
GCTGCCTTGAATGAAAATGTTCTGTGAAATTTTTTGCAAAAGCTTTACTAGGTTTTTTTTTAATTGTGAAATTTTGTAAAGGCAGGAAAT
GGATTAAAACGAGCATGCTAAATATATTTTTCAAAAAAGCAATAATTTTACATGTACAGAAATTATCCTAACCTTTAATACTGGCGAGAG
CAACAGTTTACTTAATACGGTAATGGACTAGTGCAGTTTTTGTAGACAGTGGGCTTCTGATACAAAGTCTTGTTTAAACACAGACACACA
CACACACAAACACACACACACACCCTAAAGTGTGGGTTTCCTGTTCTAATGATTTGTTGAATATTATTATATTATTATTATTATTATTAT
TATTATTGTTATTGTTATTAGTAATGTTTGGTTCTGGATTCTACTTGTTACTGAGTTTAAATTACTTGACGGTTCAGGTTACTTTGCAAC
ACTTTCAAACGATGCAATGTAACTGGCTAGCTTATATATATATATATATATATATATATATATATTTTTTTTTTTTTTTACTTATTTTTT
TCTGATATTCTTACACCAGATATGTACGAAAATGATCTGTCCTGTTGGTGTAATTAGGAATGTCCATGCAGATACAGTTAAACAACTGTA
ATTGACTGTTCTGTAAAGTTATTTTGGGCAAAGTTGCGGAGACACATTCCTCTGTCCACCTAAGAAATCAGAAGACTCTTCTGTTGATTT
ATGTTTAATCATTTCAGTAGTTTCCCCACAGTGATCATTTCTGCATTTTCTGGCTTTTGTTTTCTTGGCTGAAAGTGAATGGTGACTGTT
AGGAATGTCAGGGACTAGTGACCCAGTCCTGTTTCTCTGTGTTTTAGTTATTAAAAAGAAATTCTGTACCCAAAGTGACACGAAAGTGTA
GTCTACATTTTTACTGTTTCAGAAGCGGCATGGAAAAGTGCAGTTGGCCTTTGGAGCTGGAAGTGTCTTGCTGGTGAGGCTCCATCCTGG
AGGCTCTGGTGGGGAGTGGGCTGGCGCTGGGGCCCTGCCGGCCGCGTGCTGGATCCTTCCTGGCTTGCAGGAGAGCAGGCGTGGAGGACA
GTCAGCTTGCGGGGCCGCGCAGGGTGCACAGAGTGCAGGAGGAAGGTTTTCACCCAGTTAAACAGACTGGGGAGCCCCCCCAAGAACGCC
ATCCCTTGAGGCCAGCTGTGGGCAGGCCTGGATGTGTGGTCCCTTCCTTCCACCCATCGTCAGTATTGTGTTGGTTTGTTAATTTGTTGA
TTTGGTCATAGTATTTAATATGATTTGTGTTTCCTTATTTATTTAGCCACCGTTTTGATTGCCTTTTTTTTTCCGAATGGTAATTTCTGC
ATGATACACTTCTGTACGTTGTCTTCTGACTGTTACAGACTTTCTACTACCTCTCCCGATCTGCTGTTTCCTTGTTTCTTAACAGGATTT
TTTACAGTGTTGCGTCTAATGTAACTTAGACAATAAAGGGTTTGGTTGTCTACACTGCAGCTTCTCGGTGTCTCTCCCCTGCTTTCCGCT
CGCTGCTTCCCGCTCTGCCCCTGCTGGGGCCTGGCTGCACCCTGGCCTGCCTTCCTATACTCTCCTGTTTCCTGCTCATATCTCTTCCTC
ATTTTTGCGTTCAAATAACACACAGCTAATGAGCTTCTAAAAATCTTTTCAGGTTGTTCACTTGTATTCCTTAATTTGAAGAATGAATAT
TTAAATTCTCTCAAAAGTCAGATATTGAGGATCTTCTCTGGGAAATTGGCCACTGTACCTGCCCACCTTTCTGCCTGGTTCCCTGGAAGG
TCTTATTGTCATCTTAGACGGACAGATTTCATTCTCAGCACCATACAGATTTGGCTTCAAAGCCAGGTGAATTTTGCCTTTGAGGCTCTG
AAAAGTATTAAGTGTTTTAAGAGGTCCCCCAATATTTACTTATTTATTTTTTAAACCAAGAAAGACACTGGTTCCCTGAAAAGCAGGTGC
TTCAGGAAGTAGCAATTGGGAGTTGCATACAGTTACTTCGTCAGAGAAAGGAGCGCCCAGTATGACAGGCCCCCACCCCTGATCCGGCCA
CTGTGCACAGGTCGCTGAGGGTGTGAGAACACCTCTGCAGGGGCTCCGGCACATGTGGGTTTCATCGTCTCACACTCCTTCAGGCTGCAG
GGGTTGAGTGCAGAAAGGGCAAGCTTCATCTCCATGGTGCCTCTCCAGGCTGGCAACTCTGGTCGGCCTCTGTTCTTTGGACAGAGAGGG
TGTAGGTTACAGGGTCAGTAGGGATGCTTTCTGGATCAAAGAAAGTGGGTGTAGTGCTTAGTCTGTTGTGTGGAAGAGGGCACCTCCTGG
GCTTTCGTGGCTGGAGACTGTCTACCAACATTCCTTCCTTCAAACTAGACAAACCCTCCTCTGCCACCCCCAGCAAATTCTCAGAGGTTT
CCAAGCTGTAGAAAAAGGAAGGAAGGAAGGACGGCATTCACATAGCTTTACTTTCTGCTTCAAAATGTCTTAAGTAGCATATGTTGTTTT
ACTGCTTTTAACTTTGGTGAGTTCTAATTTCAGAACGTTTTGTTCACTGAGCAAAAAAACAGATGAAACAACCACAGGCCAGGACTTCAA
GTGAGGAGGACGCCTTTGTTTGCCGTGGTTGGTGGGAGCACACGCCGGAGCCCGGTAACGTGCCTGTGGGAGTGACCAAGGGCCACCCGC
CCAAGGGAAAATGTTCATTCTTCATCAGCTTTGCTAATTCTGCTTTGAGGCAGTAAAATGCAAAAGACCATAGAATTTGTATTTCTTTTT
TTAAAATACAATTTATAACATTATATTTTGTACTCTTTATATTAGAATTTGTAACTAGATTGATGTATTTAACTATTTCTGAAAAAGTAA
TTCAATGTTTTAGTTGTGTGATAAAAATATTTAGATAAAACATATTCATTCTATTGGAATTTGAAATAAATAAAAACATCTTGGAGTTCT
GAGATTTGTAAGACATTTTTCCCCAATTTCAGAGGGTGGCGTAAATCGTTTGACAGCCCGCTTTGGTCTGTGGTTATTTATTTTTGTTGG
CTGAACATAAACCAAAGTGTTAATGCTCTTTATTTATGGAAGAGTTTTAGGGTAATTCACAAGATCGTTCATCTGAACAGATGCCCAGAT
GGCCCGAGTGGTTTTTTTCCAACTCTTTTGTGGACTCGAGGACATACAGTTTTTTAATGGAGACGCTGTGTTTTTCTCATTTTCTTTCAC
AGCACACATGTTATTTCCCCACTGAATACACCCACTGTTCTTACCCTTGCACTGTCACCCATACAGGACGCACAGGGATGGACGCGGACG
GAATTCTGACTCAGCCACACCTGGAGGAAATTATTGTGTCAAAAATGTGGGGACACAAGGGCTGGCACTGTGGTTTGCAATGGTTTACTG

>52091_52091_3_MBP-ZNF516_MBP_chr18_74817166_ENST00000397863_ZNF516_chr18_74092259_ENST00000443185_length(amino acids)=610AA_BP=1
MGTPVRLWLETGELWFLVPFSNCNNPLKSQSIQDGKPRRQTRIKCREGQYGGQPRRCCFSEEVTSTELSSGDQSHKMGDNASERDTGESK
AGIAASVSILENSSRETSRRQEQHRFSMDLKMPAFHPKQEVPVPGDGVEFPSSTGAEGQTGHPAEKLSDLHNKEHSGGGKRALAPDLMPL
DLSARSTRDDPSNKETASSLQAALVVHPCPYCSHKTYYPEVLWMHKRIWHRVSCNSVAPPWIQPNGYKSIRSNLVFLSRSGRTGPPPALG
GKECQPLLLARFTRTQVPGGMPGSKSGSSPLGVVTKAASMPKNKESHSGGPCALWAPGPDGYRQTKPCHGQEPHGAATQGPLAKPRQEAS
SKPVPAPGGGGFSRSATPTPTVIARAGAQPSANSKPVEKFGVPPAGAGFAPTNKHSAPDSLKAKFSAQPQGPPPAKGEGGAPPLPPREPP
SKAAQELRTLATCAAGSRGDAALQAQPGVAGAPPVLHSIKQEPVAEGHEKRLDILNIFKTYIPKDFATLYQGWGVSGPGLEHRGTLRTQA

--------------------------------------------------------------
>52091_52091_4_MBP-ZNF516_MBP_chr18_74817166_ENST00000579129_ZNF516_chr18_74092259_ENST00000443185_length(transcript)=6832nt_BP=341nt
AGCCCGGGGAGGCGGGGCCGGGGAGCTGGGTGCGCGCCCGTCCCTCGGAGCCGCCGCCGTCAGTCACCGCCGCCGCGCGCCAGAGAGAAG
CAGCCTCCGGCCCCGGCGGCCCCTGTCTCCCGACCCCGGAAGGCGAAGCAGGCTGCCCGGGGACCCCGCGCGTGGGCGCTTGAAGCCGAG
ACCAGCCTGCCCGGGCCTGGGCAGGCGGAGCAGGGCCTTGGACCCCGCGGCGCCCCTCGGCCTCGGAGCAACGAGCGCAGCGCCGCCTCT
GAAGAGCCAATCCATTCAGGATGGGAAACCACGCAGGCAAACGAGAATTAAATGCCGAGAAGGCCAGTACGGGGGACAGCCGCGCCGCTG
CTGCTTTTCCGAAGAGGTGACTTCGACCGAGCTCTCCAGTGGAGACCAGAGTCACAAGATGGGAGATAACGCCTCGGAAAGAGACACCGG
CGAGTCCAAGGCAGGGATCGCAGCTTCTGTGTCCATACTTGAAAACAGTAGCAGAGAGACTTCTAGAAGGCAAGAGCAGCACAGATTTTC
TATGGACTTAAAGATGCCAGCATTTCACCCCAAGCAGGAGGTGCCCGTCCCTGGTGATGGTGTGGAGTTCCCTTCCAGTACGGGAGCGGA
GGGCCAGACGGGTCACCCTGCAGAAAAGCTGTCCGATTTGCACAACAAGGAACACTCTGGGGGAGGGAAGCGGGCGCTGGCCCCAGACCT
CATGCCGCTAGATTTAAGTGCGAGGTCGACGCGGGATGACCCCAGCAATAAGGAGACGGCCTCCTCCCTGCAGGCGGCTTTAGTCGTTCA
CCCGTGTCCTTACTGCAGCCACAAGACCTACTACCCCGAGGTCCTGTGGATGCACAAACGCATCTGGCACCGCGTCAGCTGCAACTCCGT
GGCTCCCCCGTGGATTCAGCCCAATGGTTACAAAAGCATCAGAAGCAATTTGGTTTTCCTTTCCCGGAGCGGACGCACGGGCCCCCCGCC
TGCCCTCGGTGGCAAAGAATGCCAGCCTTTGCTCCTTGCTCGGTTCACCCGCACTCAGGTGCCAGGGGGGATGCCGGGGTCCAAAAGTGG
CTCTTCTCCCCTGGGAGTGGTCACAAAAGCCGCTAGCATGCCTAAGAATAAGGAGAGCCATTCCGGAGGTCCCTGCGCTCTGTGGGCGCC
CGGCCCTGACGGGTATCGACAGACCAAACCTTGTCACGGCCAGGAGCCACATGGCGCGGCCACACAGGGGCCCCTGGCCAAGCCCAGGCA
GGAGGCTAGCTCCAAACCGGTGCCTGCCCCGGGTGGCGGGGGCTTCAGCAGGAGCGCCACCCCTACGCCCACCGTCATCGCCCGGGCTGG
CGCGCAGCCCTCGGCCAATAGCAAGCCTGTGGAGAAGTTTGGGGTCCCCCCAGCGGGGGCTGGCTTTGCCCCCACAAATAAGCACAGTGC
CCCGGACTCCCTGAAAGCCAAATTCAGTGCTCAGCCTCAGGGTCCACCTCCTGCAAAGGGCGAAGGGGGCGCTCCTCCTCTACCTCCCCG
CGAGCCCCCCTCGAAGGCAGCCCAGGAGCTGAGGACTCTGGCCACCTGTGCTGCGGGGTCCAGGGGCGACGCGGCCTTGCAGGCCCAGCC
CGGCGTGGCTGGGGCGCCCCCCGTCCTACACTCCATCAAACAGGAGCCGGTGGCCGAGGGGCATGAGAAGCGCCTGGACATCCTCAACAT
CTTTAAGACGTACATTCCAAAGGACTTTGCGACCCTCTACCAGGGATGGGGTGTCAGCGGCCCTGGGTTGGAGCACAGAGGGACACTCCG
GACGCAGGCCCGGCCAGGAGAGTTCGTCTGCATCGAGTGCGGAAAGAGCTTCCACCAGCCCGGCCACCTCAGGGCCCACATGCGGGCACA
CTCAGTGGTGTTTGAGTCCGATGGGCCTCGGGGTTCTGAAGTTCATACCACCTCCGCAGACGCCCCCAAACAAGGGAGAGACCATTCTAA
CACAGGTACCGTCCAGACAGTGCCTCTGAGAAAGGGAACCTAAAGGCGTGTTTCCGACGCACCCCAGGTCCCCGTAACGGCCATTAGCAG
TACCCTCACGATGTCCCAGCAGCCTCCCACCTGTGACCTGGCCGCTCCATGGAAGAACAGCCGGGGAACTCCTGAGCAGACACCTCACAT
CCCGAGCCGCTGCGCTGGAGTGGAAACTGAAGGCAGATGCCTCTCCTTGTTAAACGTTCAGAAATAAATGAAGATGCTATATTCTAGAAA
TACATGTAGATACTATATACGCATTTACGTGCTCATCGTCCATAGTCCCATATTTTCTTATAATAAACAGTAGTACTGGCAGGCACAGTA
GGGGCACAAGGCATCTGTCTTATTCAAGACAAGTTTGAGACACTGGAAAAAAAGATACTTGTTGTGTGTGTTGGACAGAGTGGCGAGGCT
GAGCACTGTCACAGGGGCCTCCCATGTTAAGAGGGACTGTGGGGATGATGTCAGAACAAGACGTGGTGGATTTGAGGTTGATCGAGTATT
AATACTACTGCCTCTCCTTGTCTTAGTGGGTATTTAAAATAGTAAATAAGAGAGAGGAAGGAGGTGACGTTCAGGTGCTGTGGGAAGCAG
GCTTGGCGGAGGGGTATGATGATGAGACCCTCATTGTTCACTGGCTCCATCGCACTCCTCCCTGGGGCCGTGTGCCTGTTCCATTCTTCC
CACCATTCGAACTGAGCGAATCTGGCAAAGGAGACACGTCTGTGGGAATGCGTAGATTCCGCCTCGGAAGAGAGCTAGCGCAACACTAAG
AAAAGCAGGCTTCTTGTTTATTCTCAGGACCTTTTTGTAACAGGGCTACATTCTGCAAACTGCTTACAAAGGAAGACTATACGTCTTAAC
AAATTATTTAGCCACTGAGTCCTCCCGATTCGGACCTGTTTTAGTAATGGCAGAAGAATCCCTGAGCAGGTTCAGGTGCCCTAGATGACT
AGGGTGCTGAGCTCTGGCGCCTTCTGTCCCCACTCTTTGCCTCCCCGCCCCTTCCCTGAGCCACCCCAGCAAGTGGGTGTCTTTTCTCCC
TGGGCCTGGTGACCTCCACAGGATGAGTGACTTTGTTCATAAAGGGTGGGGATCACCAGCCCCTTGGGTGGGGGACGGCTTCATATACCT
CTTCCTCAGTAATGCAAATGCGAGTTTTTGTGGTGGGGGTTAAGGCCCATAACAAAGGATCTTAAACCATGCAGTGTACGCAATTGAAAT
GGTATTCCACAGATATAAATATTTTCTTTTCCCATTGCCGTGACACTATGTGTGATGGTAATATTTCTGAGAGTTTCAGATTTTTGCACA
TATGATTTTATGCATTATCAAAAGTTACTGCTGCCTTGAATGAAAATGTTCTGTGAAATTTTTTGCAAAAGCTTTACTAGGTTTTTTTTT
AATTGTGAAATTTTGTAAAGGCAGGAAATGGATTAAAACGAGCATGCTAAATATATTTTTCAAAAAAGCAATAATTTTACATGTACAGAA
ATTATCCTAACCTTTAATACTGGCGAGAGCAACAGTTTACTTAATACGGTAATGGACTAGTGCAGTTTTTGTAGACAGTGGGCTTCTGAT
ACAAAGTCTTGTTTAAACACAGACACACACACACACAAACACACACACACACCCTAAAGTGTGGGTTTCCTGTTCTAATGATTTGTTGAA
TATTATTATATTATTATTATTATTATTATTATTATTGTTATTGTTATTAGTAATGTTTGGTTCTGGATTCTACTTGTTACTGAGTTTAAA
TTACTTGACGGTTCAGGTTACTTTGCAACACTTTCAAACGATGCAATGTAACTGGCTAGCTTATATATATATATATATATATATATATAT
ATATTTTTTTTTTTTTTTACTTATTTTTTTCTGATATTCTTACACCAGATATGTACGAAAATGATCTGTCCTGTTGGTGTAATTAGGAAT
GTCCATGCAGATACAGTTAAACAACTGTAATTGACTGTTCTGTAAAGTTATTTTGGGCAAAGTTGCGGAGACACATTCCTCTGTCCACCT
AAGAAATCAGAAGACTCTTCTGTTGATTTATGTTTAATCATTTCAGTAGTTTCCCCACAGTGATCATTTCTGCATTTTCTGGCTTTTGTT
TTCTTGGCTGAAAGTGAATGGTGACTGTTAGGAATGTCAGGGACTAGTGACCCAGTCCTGTTTCTCTGTGTTTTAGTTATTAAAAAGAAA
TTCTGTACCCAAAGTGACACGAAAGTGTAGTCTACATTTTTACTGTTTCAGAAGCGGCATGGAAAAGTGCAGTTGGCCTTTGGAGCTGGA
AGTGTCTTGCTGGTGAGGCTCCATCCTGGAGGCTCTGGTGGGGAGTGGGCTGGCGCTGGGGCCCTGCCGGCCGCGTGCTGGATCCTTCCT
GGCTTGCAGGAGAGCAGGCGTGGAGGACAGTCAGCTTGCGGGGCCGCGCAGGGTGCACAGAGTGCAGGAGGAAGGTTTTCACCCAGTTAA
ACAGACTGGGGAGCCCCCCCAAGAACGCCATCCCTTGAGGCCAGCTGTGGGCAGGCCTGGATGTGTGGTCCCTTCCTTCCACCCATCGTC
AGTATTGTGTTGGTTTGTTAATTTGTTGATTTGGTCATAGTATTTAATATGATTTGTGTTTCCTTATTTATTTAGCCACCGTTTTGATTG
CCTTTTTTTTTCCGAATGGTAATTTCTGCATGATACACTTCTGTACGTTGTCTTCTGACTGTTACAGACTTTCTACTACCTCTCCCGATC
TGCTGTTTCCTTGTTTCTTAACAGGATTTTTTACAGTGTTGCGTCTAATGTAACTTAGACAATAAAGGGTTTGGTTGTCTACACTGCAGC
TTCTCGGTGTCTCTCCCCTGCTTTCCGCTCGCTGCTTCCCGCTCTGCCCCTGCTGGGGCCTGGCTGCACCCTGGCCTGCCTTCCTATACT
CTCCTGTTTCCTGCTCATATCTCTTCCTCATTTTTGCGTTCAAATAACACACAGCTAATGAGCTTCTAAAAATCTTTTCAGGTTGTTCAC
TTGTATTCCTTAATTTGAAGAATGAATATTTAAATTCTCTCAAAAGTCAGATATTGAGGATCTTCTCTGGGAAATTGGCCACTGTACCTG
CCCACCTTTCTGCCTGGTTCCCTGGAAGGTCTTATTGTCATCTTAGACGGACAGATTTCATTCTCAGCACCATACAGATTTGGCTTCAAA
GCCAGGTGAATTTTGCCTTTGAGGCTCTGAAAAGTATTAAGTGTTTTAAGAGGTCCCCCAATATTTACTTATTTATTTTTTAAACCAAGA
AAGACACTGGTTCCCTGAAAAGCAGGTGCTTCAGGAAGTAGCAATTGGGAGTTGCATACAGTTACTTCGTCAGAGAAAGGAGCGCCCAGT
ATGACAGGCCCCCACCCCTGATCCGGCCACTGTGCACAGGTCGCTGAGGGTGTGAGAACACCTCTGCAGGGGCTCCGGCACATGTGGGTT
TCATCGTCTCACACTCCTTCAGGCTGCAGGGGTTGAGTGCAGAAAGGGCAAGCTTCATCTCCATGGTGCCTCTCCAGGCTGGCAACTCTG
GTCGGCCTCTGTTCTTTGGACAGAGAGGGTGTAGGTTACAGGGTCAGTAGGGATGCTTTCTGGATCAAAGAAAGTGGGTGTAGTGCTTAG
TCTGTTGTGTGGAAGAGGGCACCTCCTGGGCTTTCGTGGCTGGAGACTGTCTACCAACATTCCTTCCTTCAAACTAGACAAACCCTCCTC
TGCCACCCCCAGCAAATTCTCAGAGGTTTCCAAGCTGTAGAAAAAGGAAGGAAGGAAGGACGGCATTCACATAGCTTTACTTTCTGCTTC
AAAATGTCTTAAGTAGCATATGTTGTTTTACTGCTTTTAACTTTGGTGAGTTCTAATTTCAGAACGTTTTGTTCACTGAGCAAAAAAACA
GATGAAACAACCACAGGCCAGGACTTCAAGTGAGGAGGACGCCTTTGTTTGCCGTGGTTGGTGGGAGCACACGCCGGAGCCCGGTAACGT
GCCTGTGGGAGTGACCAAGGGCCACCCGCCCAAGGGAAAATGTTCATTCTTCATCAGCTTTGCTAATTCTGCTTTGAGGCAGTAAAATGC
AAAAGACCATAGAATTTGTATTTCTTTTTTTAAAATACAATTTATAACATTATATTTTGTACTCTTTATATTAGAATTTGTAACTAGATT
GATGTATTTAACTATTTCTGAAAAAGTAATTCAATGTTTTAGTTGTGTGATAAAAATATTTAGATAAAACATATTCATTCTATTGGAATT
TGAAATAAATAAAAACATCTTGGAGTTCTGAGATTTGTAAGACATTTTTCCCCAATTTCAGAGGGTGGCGTAAATCGTTTGACAGCCCGC
TTTGGTCTGTGGTTATTTATTTTTGTTGGCTGAACATAAACCAAAGTGTTAATGCTCTTTATTTATGGAAGAGTTTTAGGGTAATTCACA
AGATCGTTCATCTGAACAGATGCCCAGATGGCCCGAGTGGTTTTTTTCCAACTCTTTTGTGGACTCGAGGACATACAGTTTTTTAATGGA
GACGCTGTGTTTTTCTCATTTTCTTTCACAGCACACATGTTATTTCCCCACTGAATACACCCACTGTTCTTACCCTTGCACTGTCACCCA
TACAGGACGCACAGGGATGGACGCGGACGGAATTCTGACTCAGCCACACCTGGAGGAAATTATTGTGTCAAAAATGTGGGGACACAAGGG

>52091_52091_4_MBP-ZNF516_MBP_chr18_74817166_ENST00000579129_ZNF516_chr18_74092259_ENST00000443185_length(amino acids)=665AA_BP=1
MGARPSLGAAAVSHRRRAPERSSLRPRRPLSPDPGRRSRLPGDPARGRLKPRPACPGLGRRSRALDPAAPLGLGATSAAPPLKSQSIQDG
KPRRQTRIKCREGQYGGQPRRCCFSEEVTSTELSSGDQSHKMGDNASERDTGESKAGIAASVSILENSSRETSRRQEQHRFSMDLKMPAF
HPKQEVPVPGDGVEFPSSTGAEGQTGHPAEKLSDLHNKEHSGGGKRALAPDLMPLDLSARSTRDDPSNKETASSLQAALVVHPCPYCSHK
TYYPEVLWMHKRIWHRVSCNSVAPPWIQPNGYKSIRSNLVFLSRSGRTGPPPALGGKECQPLLLARFTRTQVPGGMPGSKSGSSPLGVVT
KAASMPKNKESHSGGPCALWAPGPDGYRQTKPCHGQEPHGAATQGPLAKPRQEASSKPVPAPGGGGFSRSATPTPTVIARAGAQPSANSK
PVEKFGVPPAGAGFAPTNKHSAPDSLKAKFSAQPQGPPPAKGEGGAPPLPPREPPSKAAQELRTLATCAAGSRGDAALQAQPGVAGAPPV
LHSIKQEPVAEGHEKRLDILNIFKTYIPKDFATLYQGWGVSGPGLEHRGTLRTQARPGEFVCIECGKSFHQPGHLRAHMRAHSVVFESDG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MBP-ZNF516

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MBP-ZNF516

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MBP-ZNF516

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source