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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MBTD1-SRCIN1 (FusionGDB2 ID:52101)

Fusion Gene Summary for MBTD1-SRCIN1

Fusion gene summary

Fusion gene information	Fusion gene name: MBTD1-SRCIN1
	Fusion gene ID: 52101
		Hgene	Tgene
	Gene symbol	MBTD1	SRCIN1
	Gene ID	54799	80725
	Gene name	mbt domain containing 1	SRC kinase signaling inhibitor 1
	Synonyms	SA49P01	P140\|SNIP
	Cytomap	17q21.33	17q12
	Type of gene	protein-coding	protein-coding
	Description	MBT domain-containing protein 1	SRC kinase signaling inhibitor 1P130Cas-associated proteinSNAP-25-interacting proteinSNAP25-interacting proteinp140Cap
	Modification date	20200313	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000376381, ENST00000415868, ENST00000586178, ENST00000593259,	ENST00000264659, ENST00000578925, ENST00000398579,
Fusion gene scores	* DoF score	13 X 12 X 11=1716	12 X 10 X 6=720
	# samples	17	11
	** MAII score	log2(17/1716*10)=-3.33544290136184 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/720*10)=-2.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MBTD1 [Title/Abstract] AND SRCIN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MBTD1(49270143)-SRCIN1(36735044), # samples:3
Anticipated loss of major functional domain due to fusion event.	MBTD1-SRCIN1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. MBTD1-SRCIN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MBTD1-SRCIN1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SRCIN1	GO:0061098	positive regulation of protein tyrosine kinase activity	17525734
Tgene	SRCIN1	GO:0061099	negative regulation of protein tyrosine kinase activity	17525734

Fusion gene breakpoints across MBTD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SRCIN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-HQ-A2OF-01A	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-

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Fusion Gene ORF analysis for MBTD1-SRCIN1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000376381	ENST00000264659	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-
3UTR-3CDS	ENST00000376381	ENST00000578925	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-
3UTR-intron	ENST00000376381	ENST00000398579	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-
5CDS-intron	ENST00000415868	ENST00000398579	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-
5CDS-intron	ENST00000586178	ENST00000398579	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-
Frame-shift	ENST00000586178	ENST00000264659	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-
Frame-shift	ENST00000586178	ENST00000578925	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-
In-frame	ENST00000415868	ENST00000264659	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-
In-frame	ENST00000415868	ENST00000578925	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-
intron-3CDS	ENST00000593259	ENST00000264659	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-
intron-3CDS	ENST00000593259	ENST00000578925	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-
intron-intron	ENST00000593259	ENST00000398579	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000415868	MBTD1	chr17	49270143	-	ENST00000264659	SRCIN1	chr17	36735044	-	8564	1753	63	5282	1739
ENST00000415868	MBTD1	chr17	49270143	-	ENST00000578925	SRCIN1	chr17	36735044	-	6238	1753	63	5384	1773

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000415868	ENST00000264659	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-	0.000576175	0.99942386
ENST00000415868	ENST00000578925	MBTD1	chr17	49270143	-	SRCIN1	chr17	36735044	-	0.002129401	0.99787056

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Fusion Genomic Features for MBTD1-SRCIN1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MBTD1-SRCIN1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:49270143/chr17:36735044)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000376381

141_245

514

390.0

Repeat

Note=MBT 1

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000376381

253_350

514

390.0

Repeat

Note=MBT 2

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000376381

351_456

514

390.0

Repeat

Note=MBT 3

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000376381

464_560

514

390.0

Repeat

Note=MBT 4

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000415868

141_245

563

629.0

Repeat

Note=MBT 1

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000415868

253_350

563

629.0

Repeat

Note=MBT 2

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000415868

351_456

563

629.0

Repeat

Note=MBT 3

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000415868

464_560

563

629.0

Repeat

Note=MBT 4

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000586178

141_245

563

629.0

Repeat

Note=MBT 1

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000586178

253_350

563

629.0

Repeat

Note=MBT 2

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000586178

351_456

563

629.0

Repeat

Note=MBT 3

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000586178

464_560

563

629.0

Repeat

Note=MBT 4

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000376381

45_80

514

390.0

Zinc finger

FCS-type

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000415868

45_80

563

629.0

Zinc finger

FCS-type

Hgene

MBTD1

chr17:49270143

chr17:36735044

ENST00000586178

45_80

563

629.0

Zinc finger

FCS-type

Tgene

SRCIN1

chr17:49270143

chr17:36735044

ENST00000264659

654_674

1184.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SRCIN1

chr17:49270143

chr17:36735044

ENST00000264659

726_746

1184.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SRCIN1

chr17:49270143

chr17:36735044

ENST00000264659

471_504

1184.0

Compositional bias

Note=Pro-rich

Tgene

SRCIN1

chr17:49270143

chr17:36735044

ENST00000264659

956_1014

1184.0

Compositional bias

Note=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MBTD1-SRCIN1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>52101_52101_1_MBTD1-SRCIN1_MBTD1_chr17_49270143_ENST00000415868_SRCIN1_chr17_36735044_ENST00000264659_length(transcript)=8564nt_BP=1753nt
TCTCTTACTTCAAAGACTGAACATTCTTCACGATCTGAAAGGAAAAGAAGAGATTCTTTCGGGATGTTTGACGGTTATGATAGCTGCAGT
GAGGACACAAGCAGCAGCTCCAGCTCCGAAGAGAGTGAGGAAGAAGTCGCTCCTTTACCTTCTAATCTCCCGATTATCAAAAACAATGGG
CAAGTCTACACATACCCAGATGGTAAATCTGGCATGGCTACCTGTGAGATGTGTGGGATGGTTGGCGTCCGAGATGCTTTTTACTCTAAA
ACAAAGCGTTTCTGTAGCGTTTCATGTTCAAGAAGTTACTCGTCAAACTCCAAGAAGGCAAGCATTTTGGCCAGACTTCAGGGTAAGCCT
CCAACAAAGAAAGCAAAAGTTCTTCAGAAACAACCTTTAGTTGCTAAGCTAGCCGCATATGCTCAGTATCAAGCTACCTTGCAAAATCAA
GCAAAGACAAAAGCAGCAGTCTCCATGGAAGGTTTCAGCTGGGGTAACTACATCAATAGCAATAGCTTTATAGCAGCTCCGGTTACCTGT
TTTAAACATGCACCTATGGGGACCTGCTGGGGTGATATCTCAGAAAATGTGAGAGTAGAAGTTCCCAATACAGACTGCAGCCTACCTACC
AAAGTCTTCTGGATTGCTGGAATTGTAAAATTAGCAGGTTACAATGCCCTTTTAAGATATGAAGGATTTGAAAATGACTCTGGTCTGGAC
TTCTGGTGCAATATATGTGGTTCTGATATCCATCCAGTTGGTTGGTGTGCAGCCAGCGGAAAACCTCTTGTTCCTCCTAGAACTATTCAG
CATAAATATACAAACTGGAAAGCTTTTCTAGTGAAACGACTTACTGGTGCCAAAACACTGCCTCCTGATTTCTCCCAAAAGGTTTCAGAG
AGTATGCAGTATCCTTTCAAACCTTGCATGAGAGTAGAAGTGGTTGACAAGAGGCATTTGTGTCGAACACGAGTAGCAGTGGTGGAAAGT
GTAATTGGAGGAAGATTAAGACTAGTGTATGAAGAAAGCGAAGATAGAACAGATGACTTCTGGTGCCATATGCACAGCCCATTAATACAT
CATATTGGTTGGTCTCGAAGCATAGGTCATCGATTCAAAAGATCTGATATTACAAAGAAACAGGATGGACATTTTGATACACCACCACAT
TTATTTGCTAAGGTAAAAGAAGTAGACCAGAGTGGGGAATGGTTCAAGGAAGGAATGAAATTGGAAGCTATAGACCCATTAAATCTTTCT
ACAATATGTGTCGCAACCATTAGAAAGGTGCTAGCTGACGGATTCCTGATGATTGGGATCGATGGCTCAGAAGCAGCAGACGGATCTGAC
TGGTTCTGTTACCATGCAACCTCTCCTTCTATTTTCCCTGTCGGTTTCTGTGAAATTAACATGATTGAACTTACTCCACCCAGAGGTTAC
ACAAAACTTCCTTTTAAATGGTTTGACTACCTCAGGGAAACTGGCTCCATTGCAGCACCAGTAAAACTATTTAATAAGGATGTTCCAAAT
CACGGATTTCGTGTAGGAATGAAATTAGAAGCAGTAGATCTCATGGAGCCACGTTTAATATGTGTAGCCACAGTAACTCGAATTATTCAT
CGTCTCTTGAGGATACATTTTGATGGATGGGAAGAAGAGTATGATCAGTGGGTAGACTGTGAGTCACCTGACCTCTATCCTGTAGGGTGG
TGTCAGTTAACTGGATATCAACTACAGCCTCCAGCATCACAGTATCCGGAGCGGAGCAGCCCCCCCATGCTGTCTGCGGACGATGCGGAG
TACCCGCGGGAGTACCGGACCCTGGGGGGCGGGGGCGGCGGGGGCAGCGGGGGCCGGCGCTTCTCCAACGTGGGGCTGGTGCACACGTCC
GAGCGGCGGCACACGGTGATCGCGGCCCAGAGTCTGGAGGCGCTCAGCGGGCTCCAGAAGGCGGACGCCGACCGCAAGCGTGATGCCTTC
ATGGACCACCTGAAGAGCAAGTACCCACAGCACGCCCTGGCCCTGCGAGGCCAGCAGGACAGGATGCGAGAGCAGCCAAACTACTGGAGT
TTCAAGACCCGCAGCTCACGCCACACTCAGGGAGCCCAGCCCGGGCTGGCAGACCAGGCGGCAAAGCTGTCCTACGCCTCCGCCGAGTCG
CTGGAGACCATGTCGGAGGCCGAGCTGCCCCTGGGCTTCAGCAGGATGAACCGCTTCCGACAGAGCCTGCCTCTCTCCCGCTCGGCCAGC
CAGACCAAGCTGCGCTCCCCAGGGGTGCTGTTCCTGCAGTTCGGGGAGGAGACTCGGCGCGTGCACATCACGCACGAGGTCAGCAGCCTG
GACACGCTGCACGCACTCATCGCGCACATGTTCCCGCAGAAGCTCACCATGGGCATGCTTAAGTCGCCCAATACCGCCATCCTCATCAAA
GACGAGGCTCGCAACGTCTTCTACGAGCTGGAGGACGTCCGGGACATCCAGGACCGCAGTATTATCAAGATCTACAGAAAGGAGCCCCTC
TACGCTGCCTTCCCTGGCTCACATCTCACCAACGGGGACCTCCGGAGAGAGATGGTGTACGCATCGCGGGAGTCCTCGCCCACGCGGCGC
CTCAACAACCTGTCACCAGCGCCGCACCTGGCATCCGGCTCGCCGCCGCCCGGGCTGCCGTCGGGGCTGCCGTCCGGGCTGCAGTCCGGT
TCGCCGTCGCGTTCGCGCCTATCGTACGCCGGGGGGCGCCCGCCTTCGTACGCCGGCAGCCCGGTGCACCACGCGGCCGAGAGGCTGGGA
GGCGCCCCGGCCGCCCAGGGCGTCAGCCCCAGCCCCAGCGCCATCCTGGAGCGGCGCGACGTGAAGCCGGACGAGGACCTGGCGAGCAAG
GCGGGCGGCATGGTGCTGGTGAAAGGCGAGGGCCTCTATGCTGACCCCTACGGGCTGCTGCACGAGGGCCGTCTGAGCCTGGCCGCGGCC
GCCGGCGACCCGTTCGCCTACCCGGGCGCCGGCGGCCTCTACAAGCGCGGCTCGGTGCGCTCGCTCAGCACCTACTCGGCCGCCGCGCTG
CAGTCCGATCTGGAGGACTCCCTGTACAAGGCGGCGGGCGGCGGCGGCCCGCTGTACGGCGACGGCTACGGCTTCCGCCTGCCGCCTTCG
TCACCGCAGAAGCTGGCCGACGTGGCAGCACCCCCCGGAGGTCCCCCGCCACCGCACAGCCCCTACTCGGGGCCGCCCAGCCGCGGCTCG
CCAGTGCGCCAGTCCTTCCGCAAGGACTCGGGCTCCTCGTCCGTCTTTGCCGAGAGTCCTGGAGGGAAGACCCGCAGCGCGGGGAGCGCC
TCGACGGCCGGAGCTCCCCCTTCGGAGCTCTTCCCTGGGCCTGGGGAACGCTCGCTGGTTGGGTTCGGGCCGCCAGTGCCAGCCAAGGAC
ACGGAGACCAGGGAGCGCATGGAGGCCATGGAGAAGCAGATTGCCAGCCTCACAGGCCTGGTGCAGAGCGCCTTACTGCGAGGCTCTGAG
CCTGAGACCCCCAGCGAGAAGATTGAAGGCTCCAATGGAGCAGCCACCCCCTCAGCACCCTGTGGGTCAGGCGGCCGGAGCAGCGGGGCC
ACCCCGGTGTCCGGCCCGCCCCCGCCCTCGGCCAGCAGCACCCCCGCAGGTCAGCCTACCGCCGTTAGCCGGCTGCAGATGCAGCTTCAC
CTGCGAGGCCTGCAGAACAGCGCCAGTGACTTGCGCGGCCAGCTCCAGCAGTTGCGCAAGCTCCAGCTACAGAACCAGGAGTCGGTGCGC
GCGCTGCTGAAGCGCACGGAGGCAGAGCTGAGCATGCGCGTGTCGGAGGCGGCGCGGCGGCAGGAGGACCCGCTGCAGCGGCAGCGCACC
CTGGTGGAAGAGGAACGGCTGCGCTATCTCAACGACGAGGAGCTTATTACCCAGCAGCTCAATGACCTGGAGAAATCGGTGGAGAAGATC
CAGAGAGACGTGTCCCACAACCACCGGCTGGTGCCCGGCCCTGAGCTGGAGGAGAAGGCACTGGTGCTGAAGCAGCTCGGGGAGACGCTG
ACAGAGCTCAAGGCTCACTTCCCGGGCCTGCAGAGCAAGATGCGGGTGGTGCTGCGCGTGGAGGTGGAGGCGGTGAAGTTCCTGAAGGAG
GAGCCCCAGCGCCTGGATGGGCTCCTCAAGCGCTGCCGCGGGGTCACGGACACGCTGGCCCAGATCCGAAGGCAAGTGGATGAGGGTGTG
TGGCCACCCCCCAACAATCTCCTGAGTCAGTCCCCCAAGAAGGTGACGGCAGAGACTGACTTCAACAAGAGCGTGGACTTCGAAATGCCA
CCCCCCAGCCCCCCGCTGAACCTGCATGAGCTGAGCGGGCCAGCTGAAGGAGCCTCTCTTACCCCCAAGGGGGGCAACCCCACCAAAGGC
CTGGACACTCCTGGCAAGAGAAGCGTGGACAAAGCTGTGTCTGTTGAGGCTGCAGAGCGAGACTGGGAGGAGAAGCGGGCAGCCCTGACC
CAGTACAGTGCCAAGGACATCAACCGGCTGCTGGAAGAGACACAGGCAGAGCTGCTCAAGGCCATCCCTGACCTGGACTGTGCCAGCAAG
GCCCATCCAGGCCCGGCCCCCACTCCAGATCACAAGCCCCCCAAGGCCCCCCACGGCCAGAAGGCAGCCCCCCGAACGGAGCCCAGTGGG
AGGAGGGGCTCAGATGAGTTGACCGTGCCCCGATACCGCACAGAGAAGCCCTCCAAGTCGCCCCCACCGCCCCCTCCCCGCCGGAGCTTC
CCCTCCTCCCATGGCCTGACCACCACACGTACCGGAGAGGTGGTGGTCACCAGCAAGAAGGACTCGGCCTTCATCAAGAAGGCTGAGTCC
GAGGAGCTGGAGGTGCAGAAGCCCCAGGTGAAGCTGCGCCGGGCTGTGTCTGAGGTGGCCCGCCCAGCCTCCACACCACCCATCATGGCC
TCGGCCATCAAGGACGAGGATGACGAGGATCGCATCATCGCAGAGCTAGAGAGTGGCGGAGGCAGTGTACCACCCATGAAGGTGGTGACT
CCGGGGGCCTCTCGGCTGAAGGCGGCCCAGGGCCAGGCGGGCAGCCCCGACAAAAGCAAACATGGCAAGCAGAGGGCCGAGTACATGCGG
ATCCAGGCCCAGCAGCAGGCCACTAAACCATCTAAAGAGATGAGCGGGTCGAATGAGACCTCGAGCCCAGTCTCAGAAAAGCCCTCGGCT
TCCAGAACCTCTATCCCTGTATTGACTTCCTTTGGGGCAAGGAATTCTTCCATCTCCTTCTAGAAGCCCCTCACCCCGCTGCCCCGCCTG
TCCCCCTCCCTCACTCCTGCCATTTCTCCCCTCTCTTCCTTCATCTCCACCCCACCCCACCCTACTCTCCAGACGCCCTGAGGGGTGTGC
CCTGAAGAGGAGGGTGCGGCCCTCCTCAGCGACCCCTACCCATCATCTGTTGGTGTTTTTGGTTTTGTTTTTTTTTTTTTTTTTAACAAT
TAACTTTTAATTATCTTTTTTTAAACAGTAAAACTAAAAACCAAACACACCACCTTCCTTGATCCCAGCTGGCCTCTCGCTGGCCGCACC
TGTCACATCTCTCCTTCTTCTCTTTCACCACTCTTTCCCCCAGTCCATCCTGAAGCTCCTGCACCCCCTTCCCGCCTTCCCCTCACTTCC
CAAGAATACTCCAAACAAACTCTGAACCACGGAGACTTGGAGCAGTGGGAGACCCCTCTCCCGTTTCTCGATACCTTCCTGGAGGAACGC
GGGGACATCGGACCAACCCATACATCAAGCCAGAGAGCGGGGCTTAGGGAGACTGGCCTTGGAGATGCCCCACTCCCTGTCTAAGCTCCG
ACAAGACTGTGACTTCCTCTGTGGCTGCTCTGCCTCCTCCCACTCACACCCAAGTGGGCCTGGAGTAGAGACGGACAGGCTGGAGACGAG
GCCGGAGTTTGAGAGGCCTCAGGGTGGGTGTGAGGCCATGGAGTCTGTATCCCTGGGGAGGCGCTGGCCTCCTGGGCCTTGCCGTCCAGT
GGGGAGTGGAGGGCAGAGGCCCTTTGGTCTGCTGGCTGTGGAGGGTGGGTTGCACGGACAGCCGGATATCGGGGACACTGCCTTGGGAGA
GGGCGGCCCGGACGGGTATTTGGTACTTTTAGTTTCCTGATTTAGCACTTTAAATGGCATTAACTTATTGAATGGGGATGGGGTGGGCAA
GAGTGAGGGGCCTAGAAAACCAGGTTTTGTGGCTTGCAGTTGGGGGAAGGGTCTGGTTTGAGGGAAATGGGAGGGTCGAGAGGGGCTTGA
CGGGGAGCACTGAAGACACCTGGGACCCGCAGGTGGGGTGACTTGAACTTCAGTCATCCTCTTGGCAATTTGAGGGTTTTCCCAGGAAAG
GATGAGACGTAGTTTTTCAATGGGGCTCTGGTGACCCTGGTGAGATGTCTGAAGGTCCCTGAGGCCTGACCATCCAGCCAGCGCCCCTGG
CCTGTGGACGCCCTGCCTGCCCTGCAGAGGCGGTTGGCAGTGCCGCCTGGCTTTTGGCCGGGTCCTGGGGAGGCAGAGAGAGGCCAATTT
TGGTTCTCACTCCTGGCCCCCCAGAGGGCACAGTGAGGAGCCGGTAGGGAGAGGATAGGAGAAGAGGAGGAGGAGGAGCGGGGTCCCCGG
CCGCAGGATTCCCACTTGGAGCACAAAGTGAAGTAAGCACAGGGGAGGGGGACTAGAATCAGTCCCCCATAGCAAGCACAGAAAGGAGGA
GCTGCGCAGAAGGCAGAGCCCCCCAGACCCTGGGGCCTGGCTGGGGAAGGTCCGCACCTGGGGAGAGCTGGGAGCTGTTGAAGGTTTGGG
GGGAGGGGAAACGGGTTGTGTTTCTTCATTTCTTTTTTTGTTTTTGCCTTTGTTGGTTCATCCTTGTTTTCTAGCTTTGGATCATTTTTG
TACCAAGGCGAGCAAGCCTTTTTGAAAAATAACAAAAGAGGAAAAAAAAAATCCCTCCTGGAAAAAAAAAAAAACCCTGGAAAATAGAAA
AAAAAAAAAGGACCTCATAAATGATGCAATTACTTTTAATTGCAGGCAACTCTTTACATTTAAGTGAAGTGTCTTAACATTTTATATTGT
TTTAAAAATATATTTACATATTATATATATAATATACGTAATATAAATATATATAAATATTTAAAAAAGAAAAAAAAAAGAAAACCACGG
CACTCTCCCTGGCCACTGTTTTGGCGGGGGAGGGGGGCTGGGGGGCGGGCACGTCGGCCTGGCTTCTGTGGTCCCAGTGAAATGGTCTGG
TTTGATTTGGCTGTACAGAGACCCCCTGACTTGGGAGGGGAGGGGGGAGTGGTGCCCCCTCCTCCCTCCACTCCATTACTCTCTGCTTGC
TACTTCGCTTGCCCCCAGCTCCCACCCTCAGCCCTGTGACTGGAATGTGTGCCCCACCGTCATTGTCCTGAGTTGAATGTCCCTTTGTGG
GGGAGGTGGGGGGGGCAGTGTCCATCCACGAAGGGGCAGAAGGAGGGAGCCACGTGCCCCGCCCCACCCGCTCGGGTGAAGCCCAGTGGG
ATTTGCATCTTTCTTTCTCTTTGGTTCCTGCACATTTATGGGCTGGGAGGCATCCGTGTGGAATTGCGTGCAGCCTGTGTGTGTGCTGGC
ACAAGCCCATGCACTGTGTGTGCAGACGCATGGGGCCTGCACCCACAGGCATGGCCGAGCACATGTGTGGGGGAAGGCGTGGGCACATAG
GTGCATGTAACCTGTTTGGGCATTGGCACGTGCCTACCTGCATGTTAGCGTGAGAGGAGCTTTGTGTGTGAGAACATGTGTAATGTGTGT
GCAGACATGCCGAGAGCCAGAGACTTGTGTGTGGGCCACGTACATGTGGATAGAGACGCATACATGGAGGTGCATGTAATCTGTGTCTCC
GAGTGTGTGTGTGCAGGTATGTGTGCTGGTGCAGACCCAAGTGTGTGGGTGTGCCTCTGTGTGCGTGTGTTCCATCATCCCTGCACCACT
GGCTCCAGATCCCTTCCTGAGCCCCCGTCCCCGCTGGCCCTCTCACAGCCTGCAGCACATCAGTGCCCCCAGCTGCATGCGCCTCGCTGC
TCTGTCCATCAGTGTGTGCTTGACCAAGAGAAAACTAAGACGTCTCGGGGGACCCCTGTACCTGGTCCTCTCAGCCCCCGCCCACTGTGC
TGTGTTACTCGCATGGGGGATTTCCTGCCCCTTCCACAATATGCTGTTTCCCCAGGAGCCTCAGGCCTGAGGCTCTGAGTGGGGTCCCCA
GGGGGCCCCCCGGGGTGAGCCCCGGCTCCACACCCTGCCCCATCCACCCTGTAGGGCCCATGTTGGTGTAGCAGTGATGGCTTCTGTGGA
TATTCTGTGACCTCTGTCGGTGTAACTTGACAATTTCTAAATGGAAAAGGGTTGCTGTGTTTTCTCTGTCTCTCTTTTTTAATGTCCTTT
TTTCTTCTCCCCCGCTCCCTGCTCTCTTTCCTTTTCAGTTTTTCTAGCCAAGTGTTTGGGGCTTTAATAAAACTTGTTTCTTTTTCCTCT

>52101_52101_1_MBTD1-SRCIN1_MBTD1_chr17_49270143_ENST00000415868_SRCIN1_chr17_36735044_ENST00000264659_length(amino acids)=1739AA_BP=564
MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKAS
ILARLQGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAAVSMEGFSWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEV
PNTDCSLPTKVFWIAGIVKLAGYNALLRYEGFENDSGLDFWCNICGSDIHPVGWCAASGKPLVPPRTIQHKYTNWKAFLVKRLTGAKTLP
PDFSQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQ
DGHFDTPPHLFAKVKEVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINM
IELTPPRGYTKLPFKWFDYLRETGSIAAPVKLFNKDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCE
SPDLYPVGWCQLTGYQLQPPASQYPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKA
DADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQ
SLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSI
IKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSP
VHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRS
LSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPG
GKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPC
GSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQ
EDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVE
VEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLT
PKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQK
AAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVAR
PASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETS

--------------------------------------------------------------
>52101_52101_2_MBTD1-SRCIN1_MBTD1_chr17_49270143_ENST00000415868_SRCIN1_chr17_36735044_ENST00000578925_length(transcript)=6238nt_BP=1753nt
TCTCTTACTTCAAAGACTGAACATTCTTCACGATCTGAAAGGAAAAGAAGAGATTCTTTCGGGATGTTTGACGGTTATGATAGCTGCAGT
GAGGACACAAGCAGCAGCTCCAGCTCCGAAGAGAGTGAGGAAGAAGTCGCTCCTTTACCTTCTAATCTCCCGATTATCAAAAACAATGGG
CAAGTCTACACATACCCAGATGGTAAATCTGGCATGGCTACCTGTGAGATGTGTGGGATGGTTGGCGTCCGAGATGCTTTTTACTCTAAA
ACAAAGCGTTTCTGTAGCGTTTCATGTTCAAGAAGTTACTCGTCAAACTCCAAGAAGGCAAGCATTTTGGCCAGACTTCAGGGTAAGCCT
CCAACAAAGAAAGCAAAAGTTCTTCAGAAACAACCTTTAGTTGCTAAGCTAGCCGCATATGCTCAGTATCAAGCTACCTTGCAAAATCAA
GCAAAGACAAAAGCAGCAGTCTCCATGGAAGGTTTCAGCTGGGGTAACTACATCAATAGCAATAGCTTTATAGCAGCTCCGGTTACCTGT
TTTAAACATGCACCTATGGGGACCTGCTGGGGTGATATCTCAGAAAATGTGAGAGTAGAAGTTCCCAATACAGACTGCAGCCTACCTACC
AAAGTCTTCTGGATTGCTGGAATTGTAAAATTAGCAGGTTACAATGCCCTTTTAAGATATGAAGGATTTGAAAATGACTCTGGTCTGGAC
TTCTGGTGCAATATATGTGGTTCTGATATCCATCCAGTTGGTTGGTGTGCAGCCAGCGGAAAACCTCTTGTTCCTCCTAGAACTATTCAG
CATAAATATACAAACTGGAAAGCTTTTCTAGTGAAACGACTTACTGGTGCCAAAACACTGCCTCCTGATTTCTCCCAAAAGGTTTCAGAG
AGTATGCAGTATCCTTTCAAACCTTGCATGAGAGTAGAAGTGGTTGACAAGAGGCATTTGTGTCGAACACGAGTAGCAGTGGTGGAAAGT
GTAATTGGAGGAAGATTAAGACTAGTGTATGAAGAAAGCGAAGATAGAACAGATGACTTCTGGTGCCATATGCACAGCCCATTAATACAT
CATATTGGTTGGTCTCGAAGCATAGGTCATCGATTCAAAAGATCTGATATTACAAAGAAACAGGATGGACATTTTGATACACCACCACAT
TTATTTGCTAAGGTAAAAGAAGTAGACCAGAGTGGGGAATGGTTCAAGGAAGGAATGAAATTGGAAGCTATAGACCCATTAAATCTTTCT
ACAATATGTGTCGCAACCATTAGAAAGGTGCTAGCTGACGGATTCCTGATGATTGGGATCGATGGCTCAGAAGCAGCAGACGGATCTGAC
TGGTTCTGTTACCATGCAACCTCTCCTTCTATTTTCCCTGTCGGTTTCTGTGAAATTAACATGATTGAACTTACTCCACCCAGAGGTTAC
ACAAAACTTCCTTTTAAATGGTTTGACTACCTCAGGGAAACTGGCTCCATTGCAGCACCAGTAAAACTATTTAATAAGGATGTTCCAAAT
CACGGATTTCGTGTAGGAATGAAATTAGAAGCAGTAGATCTCATGGAGCCACGTTTAATATGTGTAGCCACAGTAACTCGAATTATTCAT
CGTCTCTTGAGGATACATTTTGATGGATGGGAAGAAGAGTATGATCAGTGGGTAGACTGTGAGTCACCTGACCTCTATCCTGTAGGGTGG
TGTCAGTTAACTGGATATCAACTACAGCCTCCAGCATCACAGTATCCGGAGCGGAGCAGCCCCCCCATGCTGTCTGCGGACGATGCGGAG
TACCCGCGGGAGTACCGGACCCTGGGGGGCGGGGGCGGCGGGGGCAGCGGGGGCCGGCGCTTCTCCAACGTGGGGCTGGTGCACACGTCC
GAGCGGCGGCACACGGTGATCGCGGCCCAGAGTCTGGAGGCGCTCAGCGGGCTCCAGAAGGCGGACGCCGACCGCAAGCGTGATGCCTTC
ATGGACCACCTGAAGAGCAAGTACCCACAGCACGCCCTGGCCCTGCGAGGCCAGCAGGACAGGATGCGAGAGCAGGTTGGCGGCTGGACC
GTGGACCCCGTATGCCTCCTCAGCTCCCTCTGCTCCCACCTCCATGGCGACTCCGCCCCCTCCGGGGCTGGCCAGCCGGCCCAGCAGCCA
AACTACTGGAGTTTCAAGACCCGCAGCTCACGCCACACTCAGGGAGCCCAGCCCGGGCTGGCAGACCAGGCGGCAAAGCTGTCCTACGCC
TCCGCCGAGTCGCTGGAGACCATGTCGGAGGCCGAGCTGCCCCTGGGCTTCAGCAGGATGAACCGCTTCCGACAGAGCCTGCCTCTCTCC
CGCTCGGCCAGCCAGACCAAGCTGCGCTCCCCAGGGGTGCTGTTCCTGCAGTTCGGGGAGGAGACTCGGCGCGTGCACATCACGCACGAG
GTCAGCAGCCTGGACACGCTGCACGCACTCATCGCGCACATGTTCCCGCAGAAGCTCACCATGGGCATGCTTAAGTCGCCCAATACCGCC
ATCCTCATCAAAGACGAGGCTCGCAACGTCTTCTACGAGCTGGAGGACGTCCGGGACATCCAGGACCGCAGTATTATCAAGATCTACAGA
AAGGAGCCCCTCTACGCTGCCTTCCCTGGCTCACATCTCACCAACGGGGACCTCCGGAGAGAGATGGTGTACGCATCGCGGGAGTCCTCG
CCCACGCGGCGCCTCAACAACCTGTCACCAGCGCCGCACCTGGCATCCGGCTCGCCGCCGCCCGGGCTGCCGTCGGGGCTGCCGTCCGGG
CTGCAGTCCGGTTCGCCGTCGCGTTCGCGCCTATCGTACGCCGGGGGGCGCCCGCCTTCGTACGCCGGCAGCCCGGTGCACCACGCGGCC
GAGAGGCTGGGAGGCGCCCCGGCCGCCCAGGGCGTCAGCCCCAGCCCCAGCGCCATCCTGGAGCGGCGCGACGTGAAGCCGGACGAGGAC
CTGGCGAGCAAGGCGGGCGGCATGGTGCTGGTGAAAGGCGAGGGCCTCTATGCTGACCCCTACGGGCTGCTGCACGAGGGCCGTCTGAGC
CTGGCCGCGGCCGCCGGCGACCCGTTCGCCTACCCGGGCGCCGGCGGCCTCTACAAGCGCGGCTCGGTGCGCTCGCTCAGCACCTACTCG
GCCGCCGCGCTGCAGTCCGATCTGGAGGACTCCCTGTACAAGGCGGCGGGCGGCGGCGGCCCGCTGTACGGCGACGGCTACGGCTTCCGC
CTGCCGCCTTCGTCACCGCAGAAGCTGGCCGACGTGGCAGCACCCCCCGGAGGTCCCCCGCCACCGCACAGCCCCTACTCGGGGCCGCCC
AGCCGCGGCTCGCCAGTGCGCCAGTCCTTCCGCAAGGACTCGGGCTCCTCGTCCGTCTTTGCCGAGAGTCCTGGAGGGAAGACCCGCAGC
GCGGGGAGCGCCTCGACGGCCGGAGCTCCCCCTTCGGAGCTCTTCCCTGGGCCTGGGGAACGCTCGCTGGTTGGGTTCGGGCCGCCAGTG
CCAGCCAAGGACACGGAGACCAGGGAGCGCATGGAGGCCATGGAGAAGCAGATTGCCAGCCTCACAGGCCTGGTGCAGAGCGCCTTACTG
CGAGGCTCTGAGCCTGAGACCCCCAGCGAGAAGATTGAAGGCTCCAATGGAGCAGCCACCCCCTCAGCACCCTGTGGGTCAGGCGGCCGG
AGCAGCGGGGCCACCCCGGTGTCCGGCCCGCCCCCGCCCTCGGCCAGCAGCACCCCCGCAGGTCAGCCTACCGCCGTTAGCCGGCTGCAG
ATGCAGCTTCACCTGCGAGGCCTGCAGAACAGCGCCAGTGACTTGCGCGGCCAGCTCCAGCAGTTGCGCAAGCTCCAGCTACAGAACCAG
GAGTCGGTGCGCGCGCTGCTGAAGCGCACGGAGGCAGAGCTGAGCATGCGCGTGTCGGAGGCGGCGCGGCGGCAGGAGGACCCGCTGCAG
CGGCAGCGCACCCTGGTGGAAGAGGAACGGCTGCGCTATCTCAACGACGAGGAGCTTATTACCCAGCAGCTCAATGACCTGGAGAAATCG
GTGGAGAAGATCCAGAGAGACGTGTCCCACAACCACCGGCTGGTGCCCGGCCCTGAGCTGGAGGAGAAGGCACTGGTGCTGAAGCAGCTC
GGGGAGACGCTGACAGAGCTCAAGGCTCACTTCCCGGGCCTGCAGAGCAAGATGCGGGTGGTGCTGCGCGTGGAGGTGGAGGCGGTGAAG
TTCCTGAAGGAGGAGCCCCAGCGCCTGGATGGGCTCCTCAAGCGCTGCCGCGGGGTCACGGACACGCTGGCCCAGATCCGAAGGCAAGTG
GATGAGGGTGTGTGGCCACCCCCCAACAATCTCCTGAGTCAGTCCCCCAAGAAGGTGACGGCAGAGACTGACTTCAACAAGAGCGTGGAC
TTCGAAATGCCACCCCCCAGCCCCCCGCTGAACCTGCATGAGCTGAGCGGGCCAGCTGAAGGAGCCTCTCTTACCCCCAAGGGGGGCAAC
CCCACCAAAGGCCTGGACACTCCTGGCAAGAGAAGCGTGGACAAAGCTGTGTCTGTTGAGGCTGCAGAGCGAGACTGGGAGGAGAAGCGG
GCAGCCCTGACCCAGTACAGTGCCAAGGACATCAACCGGCTGCTGGAAGAGACACAGGCAGAGCTGCTCAAGGCCATCCCTGACCTGGAC
TGTGCCAGCAAGGCCCATCCAGGCCCGGCCCCCACTCCAGATCACAAGCCCCCCAAGGCCCCCCACGGCCAGAAGGCAGCCCCCCGAACG
GAGCCCAGTGGGAGGAGGGGCTCAGATGAGTTGACCGTGCCCCGATACCGCACAGAGAAGCCCTCCAAGTCGCCCCCACCGCCCCCTCCC
CGCCGGAGCTTCCCCTCCTCCCATGGCCTGACCACCACACGTACCGGAGAGGTGGTGGTCACCAGCAAGAAGGACTCGGCCTTCATCAAG
AAGGCTGAGTCCGAGGAGCTGGAGGTGCAGAAGCCCCAGGTGAAGCTGCGCCGGGCTGTGTCTGAGGTGGCCCGCCCAGCCTCCACACCA
CCCATCATGGCCTCGGCCATCAAGGACGAGGATGACGAGGATCGCATCATCGCAGAGCTAGAGAGTGGCGGAGGCAGTGTACCACCCATG
AAGGTGGTGACTCCGGGGGCCTCTCGGCTGAAGGCGGCCCAGGGCCAGGCGGGCAGCCCCGACAAAAGCAAACATGGCAAGCAGAGGGCC
GAGTACATGCGGATCCAGGCCCAGCAGCAGGCCACTAAACCATCTAAAGAGATGAGCGGGTCGAATGAGACCTCGAGCCCAGTCTCAGAA
AAGCCCTCGGCTTCCAGAACCTCTATCCCTGTATTGACTTCCTTTGGGGCAAGGAATTCTTCCATCTCCTTCTAGAAGCCCCTCACCCCG
CTGCCCCGCCTGTCCCCCTCCCTCACTCCTGCCATTTCTCCCCTCTCTTCCTTCATCTCCACCCCACCCCACCCTACTCTCCAGACGCCC
TGAGGGGTGTGCCCTGAAGAGGAGGGTGCGGCCCTCCTCAGCGACCCCTACCCATCATCTGTTGGTGTTTTTGGTTTTGTTTTTTTTTTT
TTTTTTAACAATTAACTTTTAATTATCTTTTTTTAAACAGTAAAACTAAAAACCAAACACACCACCTTCCTTGATCCCAGCTGGCCTCTC
GCTGGCCGCACCTGTCACATCTCTCCTTCTTCTCTTTCACCACTCTTTCCCCCAGTCCATCCTGAAGCTCCTGCACCCCCTTCCCGCCTT
CCCCTCACTTCCCAAGAATACTCCAAACAAACTCTGAACCACGGAGACTTGGAGCAGTGGGAGACCCCTCTCCCGTTTCTCGATACCTTC
CTGGAGGAACGCGGGGACATCGGACCAACCCATACATCAAGCCAGAGAGCGGGGCTTAGGGAGACTGGCCTTGGAGATGCCCCACTCCCT
GTCTAAGCTCCGACAAGACTGTGACTTCCTCTGTGGCTGCTCTGCCTCCTCCCACTCACACCCAAGTGGGCCTGGAGTAGAGACGGACAG
GCTGGAGACGAGGCCGGAGTTTGAGAGGCCTCAGGGTGGGTGTGAGGCCATGGAGTCTGTATCCCTGGGGAGGCGCTGGCCTCCTGGGCC
TTGCCGTCCAGTGGGGAGTGGAGGGCAGAGGCCCTTTGGTCTGCTGGCTGTGGAGGGTGGGTTGCACGGACAGCCGGATATCGGGGACAC

>52101_52101_2_MBTD1-SRCIN1_MBTD1_chr17_49270143_ENST00000415868_SRCIN1_chr17_36735044_ENST00000578925_length(amino acids)=1773AA_BP=564
MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKAS
ILARLQGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAAVSMEGFSWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEV
PNTDCSLPTKVFWIAGIVKLAGYNALLRYEGFENDSGLDFWCNICGSDIHPVGWCAASGKPLVPPRTIQHKYTNWKAFLVKRLTGAKTLP
PDFSQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQ
DGHFDTPPHLFAKVKEVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINM
IELTPPRGYTKLPFKWFDYLRETGSIAAPVKLFNKDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCE
SPDLYPVGWCQLTGYQLQPPASQYPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKA
DADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAPSGAGQPAQQPNYWSFKTRSSRHTQGAQPGLA
DQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTM
GMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPP
GLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPY
GLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPP
PHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASL
TGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQ
LRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELE
EKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTA
ETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAE
LLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVT
SKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MBTD1-SRCIN1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	SRCIN1	chr17:49270143	chr17:36735044	ENST00000264659		0	19	647_697	7.333333333333333	1184.0	SNAP25

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MBTD1-SRCIN1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MBTD1-SRCIN1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source