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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AP1S3-LRRFIP1 (FusionGDB2 ID:5211)

Fusion Gene Summary for AP1S3-LRRFIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: AP1S3-LRRFIP1
Fusion gene ID: 5211
HgeneTgene
Gene symbol

AP1S3

LRRFIP1

Gene ID

130340

9208

Gene nameadaptor related protein complex 1 subunit sigma 3LRR binding FLII interacting protein 1
SynonymsPSORS15FLAP-1|FLAP1|FLIIAP1|GCF-2|GCF2|HUFI-1|TRIP
Cytomap

2q36.1

2q37.3

Type of geneprotein-codingprotein-coding
DescriptionAP-1 complex subunit sigma-3adapter-related protein complex 1 subunit sigma-1Cadaptor protein complex AP-1 sigma-1C subunitadaptor related protein complex 1 sigma 3 subunitadaptor-related protein complex 1 subunit sigma-1Cclathrin assembly protein coleucine-rich repeat flightless-interacting protein 1GC-binding factor 2LRR FLII-interacting protein 1NEDD8-conjugating enzymeTAR RNA-interacting proteinleucine rich repeat (in FLII) interacting protein 1
Modification date2020031320200313
UniProtAcc.

Q32MZ4

Ensembl transtripts involved in fusion geneENST00000396653, ENST00000396654, 
ENST00000409375, ENST00000423110, 
ENST00000443700, ENST00000446015, 
ENST00000244815, ENST00000289175, 
ENST00000392000, ENST00000468950, 
ENST00000308482, 
Fusion gene scores* DoF score6 X 6 X 3=10814 X 13 X 6=1092
# samples 615
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AP1S3 [Title/Abstract] AND LRRFIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAP1S3(224702164)-LRRFIP1(238617186), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLRRFIP1

GO:0000122

negative regulation of transcription by RNA polymerase II

14522076


check buttonFusion gene breakpoints across AP1S3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRFIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-AA6IAP1S3chr2

224702164

-LRRFIP1chr2

238617186

+


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Fusion Gene ORF analysis for AP1S3-LRRFIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000396653ENST00000244815AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000396653ENST00000289175AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000396653ENST00000392000AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000396653ENST00000468950AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000396654ENST00000244815AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000396654ENST00000289175AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000396654ENST00000392000AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000396654ENST00000468950AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000409375ENST00000244815AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000409375ENST00000289175AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000409375ENST00000392000AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000409375ENST00000468950AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000423110ENST00000244815AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000423110ENST00000289175AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000423110ENST00000392000AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000423110ENST00000468950AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000443700ENST00000244815AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000443700ENST00000289175AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000443700ENST00000392000AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000443700ENST00000468950AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000446015ENST00000244815AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000446015ENST00000289175AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000446015ENST00000392000AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
5CDS-intronENST00000446015ENST00000468950AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
In-frameENST00000396653ENST00000308482AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
In-frameENST00000396654ENST00000308482AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
In-frameENST00000409375ENST00000308482AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
In-frameENST00000423110ENST00000308482AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
In-frameENST00000443700ENST00000308482AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+
In-frameENST00000446015ENST00000308482AP1S3chr2

224702164

-LRRFIP1chr2

238617186

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000443700AP1S3chr2224702164-ENST00000308482LRRFIP1chr2238617186+2765155591981640
ENST00000396654AP1S3chr2224702164-ENST00000308482LRRFIP1chr2238617186+2745135391961640
ENST00000396653AP1S3chr2224702164-ENST00000308482LRRFIP1chr2238617186+2745135391961640
ENST00000446015AP1S3chr2224702164-ENST00000308482LRRFIP1chr2238617186+264737341863609
ENST00000409375AP1S3chr2224702164-ENST00000308482LRRFIP1chr2238617186+270494911920609
ENST00000423110AP1S3chr2224702164-ENST00000308482LRRFIP1chr2238617186+2745135391961640

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000443700ENST00000308482AP1S3chr2224702164-LRRFIP1chr2238617186+0.001891630.9981084
ENST00000396654ENST00000308482AP1S3chr2224702164-LRRFIP1chr2238617186+0.0018939640.998106
ENST00000396653ENST00000308482AP1S3chr2224702164-LRRFIP1chr2238617186+0.0018939640.998106
ENST00000446015ENST00000308482AP1S3chr2224702164-LRRFIP1chr2238617186+0.0017195240.9982805
ENST00000409375ENST00000308482AP1S3chr2224702164-LRRFIP1chr2238617186+0.0019210090.99807894
ENST00000423110ENST00000308482AP1S3chr2224702164-LRRFIP1chr2238617186+0.0018939640.998106

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Fusion Genomic Features for AP1S3-LRRFIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AP1S3chr2224702164-LRRFIP1chr2238617186+8.78E-091
AP1S3chr2224702164-LRRFIP1chr2238617186+8.78E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AP1S3-LRRFIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:224702164/chr2:238617186)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LRRFIP1

Q32MZ4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRFIP1chr2:224702164chr2:238617186ENST00000244815010128_25022785.0Coiled coilOntology_term=ECO:0000269
TgeneLRRFIP1chr2:224702164chr2:238617186ENST0000028917508128_25022753.0Coiled coilOntology_term=ECO:0000269
TgeneLRRFIP1chr2:224702164chr2:238617186ENST00000308482024128_25032641.0Coiled coilOntology_term=ECO:0000269
TgeneLRRFIP1chr2:224702164chr2:238617186ENST00000392000011128_25022809.0Coiled coilOntology_term=ECO:0000269
TgeneLRRFIP1chr2:224702164chr2:238617186ENST00000244815010567_59322785.0Compositional biasNote=Lys-rich
TgeneLRRFIP1chr2:224702164chr2:238617186ENST0000028917508567_59322753.0Compositional biasNote=Lys-rich
TgeneLRRFIP1chr2:224702164chr2:238617186ENST00000308482024567_59332641.0Compositional biasNote=Lys-rich
TgeneLRRFIP1chr2:224702164chr2:238617186ENST00000392000011567_59322809.0Compositional biasNote=Lys-rich
TgeneLRRFIP1chr2:224702164chr2:238617186ENST00000244815010485_58422785.0RegionNote=DNA-binding
TgeneLRRFIP1chr2:224702164chr2:238617186ENST0000028917508485_58422753.0RegionNote=DNA-binding
TgeneLRRFIP1chr2:224702164chr2:238617186ENST00000308482024485_58432641.0RegionNote=DNA-binding
TgeneLRRFIP1chr2:224702164chr2:238617186ENST00000392000011485_58422809.0RegionNote=DNA-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for AP1S3-LRRFIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5211_5211_1_AP1S3-LRRFIP1_AP1S3_chr2_224702164_ENST00000396653_LRRFIP1_chr2_238617186_ENST00000308482_length(transcript)=2745nt_BP=135nt
ATTGTGGGAAGCAGCCATGGTCTAAGCCGGGCGCCTCACCTGTCAGCCGCACCGGCTCCAGCGCTCGCCTCTCGCCCTCGCTTCTCCAGC
GCTCCTTGCTCGCAAGGCGGGGGAGGCGGCGGCCCAGCCACGATGGCGGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCT
CGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAGATCTATCAGGTCCAAAAGAAATATTATGGGCTGGATACAAAATGGGGT
GACATCGAGCAGTGGATGGAAGACAGTGAGCGCTACTCTCGTAGATCCAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCA
GTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCTGACTTGGAGTATGGGGGTCCTTACGCCTGGACAAATGGTTATGATGGAGAATTGTAT
GGATCACAGTCCCTGAATAGAAGATCTGGCAGGCCCTCCTGTCTGTACAGCGCTGCCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTG
GATGAAGGCAGCTTCGGTGGGACCCGACGGGGCAGCACCTCCGGCTCCCGTGCTCCCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCC
CGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCCAGCCCTGTGGTAGAAGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAAC
ATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGGGACTTCCTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACC
GAGGCATCCATCAGGGAAATCAAGGAACTCAATGAGTTAAAGGACCAGATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAG
ATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGCTATGGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATG
TACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTTGAAGAACAGCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAA
TTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTTCAGTTTGCTGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAG
GAAATCCGACAGCTACAGCAGAAACAGGCGAGTTCTATCAGGGAGATTTCTGATCTTCAGGAAACAATAGAGTGGAAAGACAAAAAGATA
GGGGCATTAGAGAGGCAGAAAGAGTTCTTTGATTCCGTAAGGAGTGAACGGGATGATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAA
TTAAAGAAACATGGAATAATCCTAAATTCAGAAATAGCTACCAATGGAGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCT
ACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGACAGGGGATGGGACCCTAGATATTAGGTTGAAAAAGCTGGTTGATGAACGG
GAATGCTTATTGGAACAGATTAAGAAACTCAAAGGGCAGCTGGAGGAGAGACAGAAGATTGGCAAACTAGACAATCTTCGATCTGAAGAT
GATGTCTTGGAAAACGGGACAGACATGCATGTAATGGACCTACAAAGGGATGCCAACAGACAGATCAGCGACCTCAAATTTAAACTTGCA
AAATCTGAGCAAGAGATAACTGCATTAGAACAAAATGTAATAAGGTTAGAGAGTCAAGTATCACGTTACAAATCAGCGGCTGAAAATGCA
GAAAAAATAGAAGATGAACTTAAGGCAGAAAAACGGAAACTCCAAAGAGAGCTCCGCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTG
AGCAACGGCCACTTAGTGAAGCGTCTGGAAAAAATGAAAGCAAATCGGAGTGCACTCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGG
CAACTGGTTGGTGACTGGAGAGCATTGTTTCATAGGCTTTTCTCTGTCCTATCTGGGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACG
AAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCCCGTGCCATGGCTCACCCCAGGGAGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGA
CCCCTGGCCCGGGCTGGCGCCGACGCTCAGAACCTGCAGGTACTTCATAAGCACACAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCAC
AGCAGCCTCTGAATGCCGCTGGAAGTGATGATCAAAGTAAAGATTCAGTTGGGACTTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAA
GATTAAGGGGAAATGTTACAGTGTTGGGACTTCCTTTCATGGCAGAATCTACAATTTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCT
TTTCATACACAAAACACTGTGGAACCACAAGCCATTACCAAGCAAAACTCTTTCACTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGA
CCTTAAGAAGACTCTTTACAGGCAACAAATGAAGCTTTTCTAAGGGATTTTTGCATCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTA
ATTAGGCAATAGCTTCACTGAAAATGACAGCTTTTCATTGCATTATTTAATCCTTATATTTGGAATTGAAGTCGTTAACTTCTTTTAAAG

>5211_5211_1_AP1S3-LRRFIP1_AP1S3_chr2_224702164_ENST00000396653_LRRFIP1_chr2_238617186_ENST00000308482_length(amino acids)=640AA_BP=32
MSAAPAPALASRPRFSSAPCSQGGGGGGPATMAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYS
RRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGST
SGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNEL
KDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQF
QFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIA
TNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMD
LQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMK

--------------------------------------------------------------
>5211_5211_2_AP1S3-LRRFIP1_AP1S3_chr2_224702164_ENST00000396654_LRRFIP1_chr2_238617186_ENST00000308482_length(transcript)=2745nt_BP=135nt
ATTGTGGGAAGCAGCCATGGTCTAAGCCGGGCGCCTCACCTGTCAGCCGCACCGGCTCCAGCGCTCGCCTCTCGCCCTCGCTTCTCCAGC
GCTCCTTGCTCGCAAGGCGGGGGAGGCGGCGGCCCAGCCACGATGGCGGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCT
CGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAGATCTATCAGGTCCAAAAGAAATATTATGGGCTGGATACAAAATGGGGT
GACATCGAGCAGTGGATGGAAGACAGTGAGCGCTACTCTCGTAGATCCAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCA
GTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCTGACTTGGAGTATGGGGGTCCTTACGCCTGGACAAATGGTTATGATGGAGAATTGTAT
GGATCACAGTCCCTGAATAGAAGATCTGGCAGGCCCTCCTGTCTGTACAGCGCTGCCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTG
GATGAAGGCAGCTTCGGTGGGACCCGACGGGGCAGCACCTCCGGCTCCCGTGCTCCCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCC
CGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCCAGCCCTGTGGTAGAAGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAAC
ATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGGGACTTCCTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACC
GAGGCATCCATCAGGGAAATCAAGGAACTCAATGAGTTAAAGGACCAGATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAG
ATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGCTATGGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATG
TACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTTGAAGAACAGCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAA
TTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTTCAGTTTGCTGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAG
GAAATCCGACAGCTACAGCAGAAACAGGCGAGTTCTATCAGGGAGATTTCTGATCTTCAGGAAACAATAGAGTGGAAAGACAAAAAGATA
GGGGCATTAGAGAGGCAGAAAGAGTTCTTTGATTCCGTAAGGAGTGAACGGGATGATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAA
TTAAAGAAACATGGAATAATCCTAAATTCAGAAATAGCTACCAATGGAGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCT
ACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGACAGGGGATGGGACCCTAGATATTAGGTTGAAAAAGCTGGTTGATGAACGG
GAATGCTTATTGGAACAGATTAAGAAACTCAAAGGGCAGCTGGAGGAGAGACAGAAGATTGGCAAACTAGACAATCTTCGATCTGAAGAT
GATGTCTTGGAAAACGGGACAGACATGCATGTAATGGACCTACAAAGGGATGCCAACAGACAGATCAGCGACCTCAAATTTAAACTTGCA
AAATCTGAGCAAGAGATAACTGCATTAGAACAAAATGTAATAAGGTTAGAGAGTCAAGTATCACGTTACAAATCAGCGGCTGAAAATGCA
GAAAAAATAGAAGATGAACTTAAGGCAGAAAAACGGAAACTCCAAAGAGAGCTCCGCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTG
AGCAACGGCCACTTAGTGAAGCGTCTGGAAAAAATGAAAGCAAATCGGAGTGCACTCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGG
CAACTGGTTGGTGACTGGAGAGCATTGTTTCATAGGCTTTTCTCTGTCCTATCTGGGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACG
AAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCCCGTGCCATGGCTCACCCCAGGGAGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGA
CCCCTGGCCCGGGCTGGCGCCGACGCTCAGAACCTGCAGGTACTTCATAAGCACACAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCAC
AGCAGCCTCTGAATGCCGCTGGAAGTGATGATCAAAGTAAAGATTCAGTTGGGACTTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAA
GATTAAGGGGAAATGTTACAGTGTTGGGACTTCCTTTCATGGCAGAATCTACAATTTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCT
TTTCATACACAAAACACTGTGGAACCACAAGCCATTACCAAGCAAAACTCTTTCACTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGA
CCTTAAGAAGACTCTTTACAGGCAACAAATGAAGCTTTTCTAAGGGATTTTTGCATCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTA
ATTAGGCAATAGCTTCACTGAAAATGACAGCTTTTCATTGCATTATTTAATCCTTATATTTGGAATTGAAGTCGTTAACTTCTTTTAAAG

>5211_5211_2_AP1S3-LRRFIP1_AP1S3_chr2_224702164_ENST00000396654_LRRFIP1_chr2_238617186_ENST00000308482_length(amino acids)=640AA_BP=32
MSAAPAPALASRPRFSSAPCSQGGGGGGPATMAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYS
RRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGST
SGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNEL
KDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQF
QFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIA
TNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMD
LQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMK

--------------------------------------------------------------
>5211_5211_3_AP1S3-LRRFIP1_AP1S3_chr2_224702164_ENST00000409375_LRRFIP1_chr2_238617186_ENST00000308482_length(transcript)=2704nt_BP=94nt
GTCAGCCGCACCGGCTCCAGCGCTCGCCTCTCGCCCTCGCTTCTCCAGCGCTCCTTGCTCGCAAGGCGGGGGAGGCGGCGGCCCAGCCAC
GATGGCGGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGA
GATCTATCAGGTCCAAAAGAAATATTATGGGCTGGATACAAAATGGGGTGACATCGAGCAGTGGATGGAAGACAGTGAGCGCTACTCTCG
TAGATCCAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCAGTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCTGACTTGGA
GTATGGGGGTCCTTACGCCTGGACAAATGGTTATGATGGAGAATTGTATGGATCACAGTCCCTGAATAGAAGATCTGGCAGGCCCTCCTG
TCTGTACAGCGCTGCCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTGGATGAAGGCAGCTTCGGTGGGACCCGACGGGGCAGCACCTC
CGGCTCCCGTGCTCCCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCCCGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCCAGCCCTGT
GGTAGAAGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGG
GACTTCCTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGAACTCAATGAGTTAAA
GGACCAGATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAGATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAGAA
GGCTATGGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTTGA
AGAACAGCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTTCA
GTTTGCTGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAGGAAATCCGACAGCTACAGCAGAAACAGGCGAGTTCTATCAG
GGAGATTTCTGATCTTCAGGAAACAATAGAGTGGAAAGACAAAAAGATAGGGGCATTAGAGAGGCAGAAAGAGTTCTTTGATTCCGTAAG
GAGTGAACGGGATGATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAATTAAAGAAACATGGAATAATCCTAAATTCAGAAATAGCTAC
CAATGGAGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGAC
AGGGGATGGGACCCTAGATATTAGGTTGAAAAAGCTGGTTGATGAACGGGAATGCTTATTGGAACAGATTAAGAAACTCAAAGGGCAGCT
GGAGGAGAGACAGAAGATTGGCAAACTAGACAATCTTCGATCTGAAGATGATGTCTTGGAAAACGGGACAGACATGCATGTAATGGACCT
ACAAAGGGATGCCAACAGACAGATCAGCGACCTCAAATTTAAACTTGCAAAATCTGAGCAAGAGATAACTGCATTAGAACAAAATGTAAT
AAGGTTAGAGAGTCAAGTATCACGTTACAAATCAGCGGCTGAAAATGCAGAAAAAATAGAAGATGAACTTAAGGCAGAAAAACGGAAACT
CCAAAGAGAGCTCCGCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTGAGCAACGGCCACTTAGTGAAGCGTCTGGAAAAAATGAAAGC
AAATCGGAGTGCACTCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGGCAACTGGTTGGTGACTGGAGAGCATTGTTTCATAGGCTTTT
CTCTGTCCTATCTGGGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACGAAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCCCGTGCCAT
GGCTCACCCCAGGGAGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGACCCCTGGCCCGGGCTGGCGCCGACGCTCAGAACCTGCAGGT
ACTTCATAAGCACACAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCACAGCAGCCTCTGAATGCCGCTGGAAGTGATGATCAAAGTAAA
GATTCAGTTGGGACTTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAAGATTAAGGGGAAATGTTACAGTGTTGGGACTTCCTTTCATG
GCAGAATCTACAATTTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCTTTTCATACACAAAACACTGTGGAACCACAAGCCATTACCAA
GCAAAACTCTTTCACTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGACCTTAAGAAGACTCTTTACAGGCAACAAATGAAGCTTTTCT
AAGGGATTTTTGCATCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTAATTAGGCAATAGCTTCACTGAAAATGACAGCTTTTCATTGC
ATTATTTAATCCTTATATTTGGAATTGAAGTCGTTAACTTCTTTTAAAGAATGTACTATTAGAAAAATTAAAAATGAAATGTTGAGAGAC

>5211_5211_3_AP1S3-LRRFIP1_AP1S3_chr2_224702164_ENST00000409375_LRRFIP1_chr2_238617186_ENST00000308482_length(amino acids)=609AA_BP=1
MAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDLE
YGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPV
VEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKK
AMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIR
EISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKST
GDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVI

--------------------------------------------------------------
>5211_5211_4_AP1S3-LRRFIP1_AP1S3_chr2_224702164_ENST00000423110_LRRFIP1_chr2_238617186_ENST00000308482_length(transcript)=2745nt_BP=135nt
ATTGTGGGAAGCAGCCATGGTCTAAGCCGGGCGCCTCACCTGTCAGCCGCACCGGCTCCAGCGCTCGCCTCTCGCCCTCGCTTCTCCAGC
GCTCCTTGCTCGCAAGGCGGGGGAGGCGGCGGCCCAGCCACGATGGCGGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCT
CGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAGATCTATCAGGTCCAAAAGAAATATTATGGGCTGGATACAAAATGGGGT
GACATCGAGCAGTGGATGGAAGACAGTGAGCGCTACTCTCGTAGATCCAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCA
GTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCTGACTTGGAGTATGGGGGTCCTTACGCCTGGACAAATGGTTATGATGGAGAATTGTAT
GGATCACAGTCCCTGAATAGAAGATCTGGCAGGCCCTCCTGTCTGTACAGCGCTGCCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTG
GATGAAGGCAGCTTCGGTGGGACCCGACGGGGCAGCACCTCCGGCTCCCGTGCTCCCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCC
CGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCCAGCCCTGTGGTAGAAGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAAC
ATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGGGACTTCCTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACC
GAGGCATCCATCAGGGAAATCAAGGAACTCAATGAGTTAAAGGACCAGATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAG
ATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGCTATGGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATG
TACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTTGAAGAACAGCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAA
TTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTTCAGTTTGCTGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAG
GAAATCCGACAGCTACAGCAGAAACAGGCGAGTTCTATCAGGGAGATTTCTGATCTTCAGGAAACAATAGAGTGGAAAGACAAAAAGATA
GGGGCATTAGAGAGGCAGAAAGAGTTCTTTGATTCCGTAAGGAGTGAACGGGATGATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAA
TTAAAGAAACATGGAATAATCCTAAATTCAGAAATAGCTACCAATGGAGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCT
ACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGACAGGGGATGGGACCCTAGATATTAGGTTGAAAAAGCTGGTTGATGAACGG
GAATGCTTATTGGAACAGATTAAGAAACTCAAAGGGCAGCTGGAGGAGAGACAGAAGATTGGCAAACTAGACAATCTTCGATCTGAAGAT
GATGTCTTGGAAAACGGGACAGACATGCATGTAATGGACCTACAAAGGGATGCCAACAGACAGATCAGCGACCTCAAATTTAAACTTGCA
AAATCTGAGCAAGAGATAACTGCATTAGAACAAAATGTAATAAGGTTAGAGAGTCAAGTATCACGTTACAAATCAGCGGCTGAAAATGCA
GAAAAAATAGAAGATGAACTTAAGGCAGAAAAACGGAAACTCCAAAGAGAGCTCCGCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTG
AGCAACGGCCACTTAGTGAAGCGTCTGGAAAAAATGAAAGCAAATCGGAGTGCACTCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGG
CAACTGGTTGGTGACTGGAGAGCATTGTTTCATAGGCTTTTCTCTGTCCTATCTGGGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACG
AAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCCCGTGCCATGGCTCACCCCAGGGAGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGA
CCCCTGGCCCGGGCTGGCGCCGACGCTCAGAACCTGCAGGTACTTCATAAGCACACAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCAC
AGCAGCCTCTGAATGCCGCTGGAAGTGATGATCAAAGTAAAGATTCAGTTGGGACTTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAA
GATTAAGGGGAAATGTTACAGTGTTGGGACTTCCTTTCATGGCAGAATCTACAATTTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCT
TTTCATACACAAAACACTGTGGAACCACAAGCCATTACCAAGCAAAACTCTTTCACTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGA
CCTTAAGAAGACTCTTTACAGGCAACAAATGAAGCTTTTCTAAGGGATTTTTGCATCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTA
ATTAGGCAATAGCTTCACTGAAAATGACAGCTTTTCATTGCATTATTTAATCCTTATATTTGGAATTGAAGTCGTTAACTTCTTTTAAAG

>5211_5211_4_AP1S3-LRRFIP1_AP1S3_chr2_224702164_ENST00000423110_LRRFIP1_chr2_238617186_ENST00000308482_length(amino acids)=640AA_BP=32
MSAAPAPALASRPRFSSAPCSQGGGGGGPATMAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYS
RRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGST
SGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNEL
KDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQF
QFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIA
TNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMD
LQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMK

--------------------------------------------------------------
>5211_5211_5_AP1S3-LRRFIP1_AP1S3_chr2_224702164_ENST00000443700_LRRFIP1_chr2_238617186_ENST00000308482_length(transcript)=2765nt_BP=155nt
CACACTTTCAGTGCCAGGGCATTGTGGGAAGCAGCCATGGTCTAAGCCGGGCGCCTCACCTGTCAGCCGCACCGGCTCCAGCGCTCGCCT
CTCGCCCTCGCTTCTCCAGCGCTCCTTGCTCGCAAGGCGGGGGAGGCGGCGGCCCAGCCACGATGGCGGAAGCCCGGCTCGCTGCAAAAC
GGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAGATCTATCAGGTCCAAAAGAAATATTATG
GGCTGGATACAAAATGGGGTGACATCGAGCAGTGGATGGAAGACAGTGAGCGCTACTCTCGTAGATCCAGAAGAAACACATCGGCTTCTG
ATGAAGACGAGCGCATGTCAGTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCTGACTTGGAGTATGGGGGTCCTTACGCCTGGACAAATG
GTTATGATGGAGAATTGTATGGATCACAGTCCCTGAATAGAAGATCTGGCAGGCCCTCCTGTCTGTACAGCGCTGCCCGGCCTTCGGGGA
GTTACCGGGCGTCTGTGTTGGATGAAGGCAGCTTCGGTGGGACCCGACGGGGCAGCACCTCCGGCTCCCGTGCTCCCTCGGAGTACAGCG
GCCACCTCAACTCCAGCTCCCGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCCAGCCCTGTGGTAGAAGAGAGACCAGAAAAAGATTTTA
CTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGGGACTTCCTCTCGGAGAGGCAGCGGAGACA
CCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGAACTCAATGAGTTAAAGGACCAGATTCAGGATGTAGAAGGCAAAT
ACATGCAGGGATTGAAAGAGATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGCTATGGTTTCCAATGCTCAGCTAGACA
ATGAAAAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTTGAAGAACAGCTGGCTGAATCTAGGCGGCAGT
ACGAAGAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTTCAGTTTGCTGAAGTCAAGGAGGCCCTGAAGC
AAAGAGAGGAAATGCTCGAGGAAATCCGACAGCTACAGCAGAAACAGGCGAGTTCTATCAGGGAGATTTCTGATCTTCAGGAAACAATAG
AGTGGAAAGACAAAAAGATAGGGGCATTAGAGAGGCAGAAAGAGTTCTTTGATTCCGTAAGGAGTGAACGGGATGATCTTAGAGAAGAAG
TAGTCATGCTGAAAGAGGAATTAAAGAAACATGGAATAATCCTAAATTCAGAAATAGCTACCAATGGAGAGACTTCCGACACCCTCAATA
ATGTTGGATACCAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGACAGGGGATGGGACCCTAGATATTAGGTTGA
AAAAGCTGGTTGATGAACGGGAATGCTTATTGGAACAGATTAAGAAACTCAAAGGGCAGCTGGAGGAGAGACAGAAGATTGGCAAACTAG
ACAATCTTCGATCTGAAGATGATGTCTTGGAAAACGGGACAGACATGCATGTAATGGACCTACAAAGGGATGCCAACAGACAGATCAGCG
ACCTCAAATTTAAACTTGCAAAATCTGAGCAAGAGATAACTGCATTAGAACAAAATGTAATAAGGTTAGAGAGTCAAGTATCACGTTACA
AATCAGCGGCTGAAAATGCAGAAAAAATAGAAGATGAACTTAAGGCAGAAAAACGGAAACTCCAAAGAGAGCTCCGCTCTGCATTGGATA
AAACAGAAGAGCTCGAGGTGAGCAACGGCCACTTAGTGAAGCGTCTGGAAAAAATGAAAGCAAATCGGAGTGCACTCTTGTCCCAGCAGT
AAATTCCAGCTCTGATCAGGCAACTGGTTGGTGACTGGAGAGCATTGTTTCATAGGCTTTTCTCTGTCCTATCTGGGAGCGCTGCTTCTT
CCCCTGCCTTCCGAGAGACGAAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCCCGTGCCATGGCTCACCCCAGGGAGCCCCAGCAGCCAC
CAGGTGCCTCTGTCTGCAGACCCCTGGCCCGGGCTGGCGCCGACGCTCAGAACCTGCAGGTACTTCATAAGCACACAGGGGCCTCGAGGG
AGCTCTGTGTCTGACCGCACAGCAGCCTCTGAATGCCGCTGGAAGTGATGATCAAAGTAAAGATTCAGTTGGGACTTGAGTTTTTTTTTT
TTTTCATGTGTCTTGCTGAAGATTAAGGGGAAATGTTACAGTGTTGGGACTTCCTTTCATGGCAGAATCTACAATTTGAGCGACTTCAGT
AGTATCTCTTAGTCTACGCTTTTCATACACAAAACACTGTGGAACCACAAGCCATTACCAAGCAAAACTCTTTCACTGGAAACAAGGGGG
CAGTCTAGAAGTAAAAGTGACCTTAAGAAGACTCTTTACAGGCAACAAATGAAGCTTTTCTAAGGGATTTTTGCATCAGTTCAGTCATAA
GAATACTTTTTTCCAGGGTAATTAGGCAATAGCTTCACTGAAAATGACAGCTTTTCATTGCATTATTTAATCCTTATATTTGGAATTGAA

>5211_5211_5_AP1S3-LRRFIP1_AP1S3_chr2_224702164_ENST00000443700_LRRFIP1_chr2_238617186_ENST00000308482_length(amino acids)=640AA_BP=32
MSAAPAPALASRPRFSSAPCSQGGGGGGPATMAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYS
RRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGST
SGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNEL
KDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQF
QFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIA
TNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMD
LQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMK

--------------------------------------------------------------
>5211_5211_6_AP1S3-LRRFIP1_AP1S3_chr2_224702164_ENST00000446015_LRRFIP1_chr2_238617186_ENST00000308482_length(transcript)=2647nt_BP=37nt
CTCGCAAGGCGGGGGAGGCGGCGGCCCAGCCACGATGGCGGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGAT
CCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAGATCTATCAGGTCCAAAAGAAATATTATGGGCTGGATACAAAATGGGGTGACATCGA
GCAGTGGATGGAAGACAGTGAGCGCTACTCTCGTAGATCCAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCAGTGGGTAG
TCGTGGAAGCCTGAGGTCGCAGCCTGACTTGGAGTATGGGGGTCCTTACGCCTGGACAAATGGTTATGATGGAGAATTGTATGGATCACA
GTCCCTGAATAGAAGATCTGGCAGGCCCTCCTGTCTGTACAGCGCTGCCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTGGATGAAGG
CAGCTTCGGTGGGACCCGACGGGGCAGCACCTCCGGCTCCCGTGCTCCCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCCCGCGCCTC
CTCCAGGGCCAGCTCGGCCCGGGCCAGCCCTGTGGTAGAAGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGG
CCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGGGACTTCCTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAGGCATC
CATCAGGGAAATCAAGGAACTCAATGAGTTAAAGGACCAGATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAGATGAAGGA
CTCTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGCTATGGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGT
TGATACCCTAAAAGATATGTTGCTGGAGCTTGAAGAACAGCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAG
GGAAAAACACGCCCACAGTATACTGCAATTTCAGTTTGCTGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAGGAAATCCG
ACAGCTACAGCAGAAACAGGCGAGTTCTATCAGGGAGATTTCTGATCTTCAGGAAACAATAGAGTGGAAAGACAAAAAGATAGGGGCATT
AGAGAGGCAGAAAGAGTTCTTTGATTCCGTAAGGAGTGAACGGGATGATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAATTAAAGAA
ACATGGAATAATCCTAAATTCAGAAATAGCTACCAATGGAGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGAT
GACAAAAGAAGAGTTAAATGCCCTCAAGTCGACAGGGGATGGGACCCTAGATATTAGGTTGAAAAAGCTGGTTGATGAACGGGAATGCTT
ATTGGAACAGATTAAGAAACTCAAAGGGCAGCTGGAGGAGAGACAGAAGATTGGCAAACTAGACAATCTTCGATCTGAAGATGATGTCTT
GGAAAACGGGACAGACATGCATGTAATGGACCTACAAAGGGATGCCAACAGACAGATCAGCGACCTCAAATTTAAACTTGCAAAATCTGA
GCAAGAGATAACTGCATTAGAACAAAATGTAATAAGGTTAGAGAGTCAAGTATCACGTTACAAATCAGCGGCTGAAAATGCAGAAAAAAT
AGAAGATGAACTTAAGGCAGAAAAACGGAAACTCCAAAGAGAGCTCCGCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTGAGCAACGG
CCACTTAGTGAAGCGTCTGGAAAAAATGAAAGCAAATCGGAGTGCACTCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGGCAACTGGT
TGGTGACTGGAGAGCATTGTTTCATAGGCTTTTCTCTGTCCTATCTGGGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACGAAGACCGT
GGCGAGCTTGGCGCTTAGGGGCTCCCGTGCCATGGCTCACCCCAGGGAGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGACCCCTGGC
CCGGGCTGGCGCCGACGCTCAGAACCTGCAGGTACTTCATAAGCACACAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCACAGCAGCCT
CTGAATGCCGCTGGAAGTGATGATCAAAGTAAAGATTCAGTTGGGACTTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAAGATTAAGG
GGAAATGTTACAGTGTTGGGACTTCCTTTCATGGCAGAATCTACAATTTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCTTTTCATAC
ACAAAACACTGTGGAACCACAAGCCATTACCAAGCAAAACTCTTTCACTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGACCTTAAGA
AGACTCTTTACAGGCAACAAATGAAGCTTTTCTAAGGGATTTTTGCATCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTAATTAGGCA
ATAGCTTCACTGAAAATGACAGCTTTTCATTGCATTATTTAATCCTTATATTTGGAATTGAAGTCGTTAACTTCTTTTAAAGAATGTACT

>5211_5211_6_AP1S3-LRRFIP1_AP1S3_chr2_224702164_ENST00000446015_LRRFIP1_chr2_238617186_ENST00000308482_length(amino acids)=609AA_BP=1
MAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDLE
YGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPV
VEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKK
AMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIR
EISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKST
GDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AP1S3-LRRFIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AP1S3-LRRFIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AP1S3-LRRFIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource