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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MCAT-ACSS2 (FusionGDB2 ID:52132)

Fusion Gene Summary for MCAT-ACSS2

Fusion gene summary

Fusion gene information	Fusion gene name: MCAT-ACSS2
	Fusion gene ID: 52132
		Hgene	Tgene
	Gene symbol	MCAT	ACSS2
	Gene ID	27349	55902
	Gene name	malonyl-CoA-acyl carrier protein transacylase	acyl-CoA synthetase short chain family member 2
	Synonyms	FASN2C\|MCT\|MCT1\|MT\|NET62\|fabD	ACAS2\|ACECS\|ACS\|ACSA\|AceCS1\|dJ1161H23.1
	Cytomap	22q13.2	20q11.22
	Type of gene	protein-coding	protein-coding
	Description	malonyl-CoA-acyl carrier protein transacylase, mitochondrial[Acyl-carrier-protein] malonyltransferase[acyl-carrier-protein] S-malonyltransferasemalonyl CoA:ACP acyltransferase (mitochondrial)mitochondrial malonyl CoA:ACP acyltransferasemitochondrial	acetyl-coenzyme A synthetase, cytoplasmicacetate thiokinaseacetate-CoA ligaseacetyl-CoA synthetase 1acetyl-Coenzyme A synthetase 2 (ADP forming)acyl-activating enzymecytoplasmic acetyl-coenzyme A synthetasepropionate--CoA ligase
	Modification date	20200313	20200313
	UniProtAcc	Q8IVS2	Q9NR19
	Ensembl transtripts involved in fusion gene	ENST00000290429, ENST00000327555, ENST00000464244,	ENST00000476922, ENST00000253382, ENST00000336325, ENST00000360596,
Fusion gene scores	* DoF score	2 X 3 X 2=12	11 X 8 X 6=528
	# samples	2	12
	** MAII score	log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(12/528*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MCAT [Title/Abstract] AND ACSS2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MCAT(43537167)-ACSS2(33513500), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MCAT	GO:0006633	fatty acid biosynthetic process	12882974

Fusion gene breakpoints across MCAT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACSS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CG-5719	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+

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Fusion Gene ORF analysis for MCAT-ACSS2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000290429	ENST00000476922	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+
5CDS-3UTR	ENST00000327555	ENST00000476922	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+
In-frame	ENST00000290429	ENST00000253382	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+
In-frame	ENST00000290429	ENST00000336325	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+
In-frame	ENST00000290429	ENST00000360596	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+
In-frame	ENST00000327555	ENST00000253382	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+
In-frame	ENST00000327555	ENST00000336325	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+
In-frame	ENST00000327555	ENST00000360596	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+
intron-3CDS	ENST00000464244	ENST00000253382	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+
intron-3CDS	ENST00000464244	ENST00000336325	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+
intron-3CDS	ENST00000464244	ENST00000360596	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+
intron-3UTR	ENST00000464244	ENST00000476922	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000290429	MCAT	chr22	43537167	-	ENST00000336325	ACSS2	chr20	33513500	+	1758	557	46	1005	319
ENST00000290429	MCAT	chr22	43537167	-	ENST00000360596	ACSS2	chr20	33513500	+	1754	557	46	1005	319
ENST00000290429	MCAT	chr22	43537167	-	ENST00000253382	ACSS2	chr20	33513500	+	1754	557	46	1005	319
ENST00000327555	MCAT	chr22	43537167	-	ENST00000336325	ACSS2	chr20	33513500	+	1728	527	16	975	319
ENST00000327555	MCAT	chr22	43537167	-	ENST00000360596	ACSS2	chr20	33513500	+	1724	527	16	975	319
ENST00000327555	MCAT	chr22	43537167	-	ENST00000253382	ACSS2	chr20	33513500	+	1724	527	16	975	319

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000290429	ENST00000336325	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+	0.011295334	0.9887046
ENST00000290429	ENST00000360596	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+	0.011390449	0.98860955
ENST00000290429	ENST00000253382	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+	0.011390449	0.98860955
ENST00000327555	ENST00000336325	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+	0.011516137	0.98848385
ENST00000327555	ENST00000360596	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+	0.0115834	0.9884166
ENST00000327555	ENST00000253382	MCAT	chr22	43537167	-	ACSS2	chr20	33513500	+	0.0115834	0.9884166

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Fusion Genomic Features for MCAT-ACSS2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MCAT-ACSS2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:43537167/chr20:33513500)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MCAT Q8IVS2	ACSS2 Q9NR19
FUNCTION: Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria. {ECO:0000269\|PubMed:12882974}.	FUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429). Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429). Can also utilize propionate with a much lower affinity (By similarity). {ECO:0000250\|UniProtKB:Q9QXG4, ECO:0000269\|PubMed:10843999, ECO:0000269\|PubMed:28003429}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ACSS2

chr22:43537167

chr20:33513500

ENST00000253382

439_441

565

715.0

Nucleotide binding

ATP

Tgene

ACSS2

chr22:43537167

chr20:33513500

ENST00000253382

463_468

565

715.0

Nucleotide binding

ATP

Tgene

ACSS2

chr22:43537167

chr20:33513500

ENST00000360596

439_441

552

702.0

Nucleotide binding

ATP

Tgene

ACSS2

chr22:43537167

chr20:33513500

ENST00000360596

463_468

552

702.0

Nucleotide binding

ATP

Tgene

ACSS2

chr22:43537167

chr20:33513500

ENST00000253382

219_222

565

715.0

Region

Coenzyme A binding

Tgene

ACSS2

chr22:43537167

chr20:33513500

ENST00000360596

219_222

552

702.0

Region

Coenzyme A binding

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Fusion Gene Sequence for MCAT-ACSS2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>52132_52132_1_MCAT-ACSS2_MCAT_chr22_43537167_ENST00000290429_ACSS2_chr20_33513500_ENST00000253382_length(transcript)=1754nt_BP=557nt
TCGGGCCTCGGTCGCCACGGTAACGCGCGCGGGCAGGTGTCCGACCATGAGCGTCCGGGTCGCACGGGTAGCGTGGGTCAGGGGCTTGGG
CGCCAGCTACCGCCGCGGCGCCTCGAGCTTCCCGGTGCCTCCGCCGGGCGCCCAGGGTGTAGCGGAGCTGCTGCGAGATGCGACCGGGGC
GGAGGAGGAGGCGCCCTGGGCGGCGACGGAGCGGCGAATGCCGGGCCAGTGCTCCGTGCTGCTCTTCCCGGGCCAGGGCAGCCAGGTGGT
GGGCATGGGCCGCGGTCTGCTCAACTACCCGCGCGTCCGCGAACTCTACGCCGCCGCCCGCCGCGTGCTGGGCTACGACCTGCTGGAACT
GAGCCTGCACGGGCCGCAGGAGACCCTGGACCGCACCGTGCACTGTCAGCCCGCGATCTTCGTGGCATCGCTGGCCGCTGTCGAGAAACT
ACATCACCTGCAGCCCTCGGTGATTGAGAACTGTGTTGCTGCTGCTGGATTCAGTGTGGGAGAGTTTGCAGCCCTAGTGTTTGCCGGAGC
CATGGAATTTGCTGAAGGCTGCCAGCGGGACCAGGATGGCTATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTATCTGGACA
CCTGCTGAGTACAGCAGAGGTGGAGTCAGCACTTGTGGAACATGAGGCTGTTGCAGAGGCAGCTGTGGTGGGCCACCCTCATCCTGTGAA
GGGTGAATGCCTCTACTGCTTTGTCACCTTGTGTGATGGCCACACCTTCAGCCCCAAGCTCACCGAGGAGCTCAAGAAGCAGATTAGAGA
AAAGATTGGCCCCATTGCCACACCAGACTACATCCAGAATGCACCTGGCTTGCCTAAAACCCGCTCAGGGAAAATCATGAGGCGAGTGCT
TCGGAAGATTGCTCAGAATGACCATGACCTCGGGGACATGTCTACTGTGGCTGACCCATCTGTCATCAGTCACCTCTTCAGCCACCGCTG
CCTGACCATCCAGTGAACATGATCCTGACCTTTACCTAGGATTCCTCCTGCTCCAAACTTTGCCCATCCTCTTTGCCCCCTCAGGAGTGC
TGAGGGCCAGTGTTGACCCACACTACCCTCCCTTGACCAGCTGTCTGGGACCGGAAACCAGCTTTGTCTCCAGGTAGAGACAACATCCTG
TGACTGCCAGGCAGAAAGGACAGGGCCCAGGTCAGCCTCAGTCTGCTGTGCCTCCAGACTGCAGAGCTCTCAGAACCCAGAACAGAGACG
AAAAGGCTACCTCTCCTACCCAAGTTAAGTGTTCAAAGGGGATGTGAGGGCCTCCACTGAAGCAGGGAGGCAGCTGTGTAATCCTATGTC
AGCTCTCTTAGGAAGCCCCAGTACTTATATTGGGCATGCACTTGCCCTTAAAAACAATGATTTGTGAGTCCAGGAACAATTTACTATTTT
TAAAATATTTTGCTGCTTCTGTTCTGGGTCTGAATTCCCTTTTGTGCCAGATGCCAGTACTGTCTGCCCATTGGCTCCAGGGGCTGTATG
GGCAGATTCAGTCTCCAGAGGGTATTCAGATCATCTGCTTCTTTGAAGGAGTAAATGTGTTTTGTTCCTAGGGCCAGAGGAGCTTGTCTT
CCTTGTCCTCTGTTCCCACCCTCCCCTGAACAGAACCCAGCCCATAAGAGACATTCTCAGATGAAACTCTGTTTTCTTGCCCCAGTCAGG

>52132_52132_1_MCAT-ACSS2_MCAT_chr22_43537167_ENST00000290429_ACSS2_chr20_33513500_ENST00000253382_length(amino acids)=319AA_BP=170
MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVREL
YAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGCQRDQDGYY
WITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAP

--------------------------------------------------------------
>52132_52132_2_MCAT-ACSS2_MCAT_chr22_43537167_ENST00000290429_ACSS2_chr20_33513500_ENST00000336325_length(transcript)=1758nt_BP=557nt
TCGGGCCTCGGTCGCCACGGTAACGCGCGCGGGCAGGTGTCCGACCATGAGCGTCCGGGTCGCACGGGTAGCGTGGGTCAGGGGCTTGGG
CGCCAGCTACCGCCGCGGCGCCTCGAGCTTCCCGGTGCCTCCGCCGGGCGCCCAGGGTGTAGCGGAGCTGCTGCGAGATGCGACCGGGGC
GGAGGAGGAGGCGCCCTGGGCGGCGACGGAGCGGCGAATGCCGGGCCAGTGCTCCGTGCTGCTCTTCCCGGGCCAGGGCAGCCAGGTGGT
GGGCATGGGCCGCGGTCTGCTCAACTACCCGCGCGTCCGCGAACTCTACGCCGCCGCCCGCCGCGTGCTGGGCTACGACCTGCTGGAACT
GAGCCTGCACGGGCCGCAGGAGACCCTGGACCGCACCGTGCACTGTCAGCCCGCGATCTTCGTGGCATCGCTGGCCGCTGTCGAGAAACT
ACATCACCTGCAGCCCTCGGTGATTGAGAACTGTGTTGCTGCTGCTGGATTCAGTGTGGGAGAGTTTGCAGCCCTAGTGTTTGCCGGAGC
CATGGAATTTGCTGAAGGCTGCCAGCGGGACCAGGATGGCTATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTATCTGGACA
CCTGCTGAGTACAGCAGAGGTGGAGTCAGCACTTGTGGAACATGAGGCTGTTGCAGAGGCAGCTGTGGTGGGCCACCCTCATCCTGTGAA
GGGTGAATGCCTCTACTGCTTTGTCACCTTGTGTGATGGCCACACCTTCAGCCCCAAGCTCACCGAGGAGCTCAAGAAGCAGATTAGAGA
AAAGATTGGCCCCATTGCCACACCAGACTACATCCAGAATGCACCTGGCTTGCCTAAAACCCGCTCAGGGAAAATCATGAGGCGAGTGCT
TCGGAAGATTGCTCAGAATGACCATGACCTCGGGGACATGTCTACTGTGGCTGACCCATCTGTCATCAGTCACCTCTTCAGCCACCGCTG
CCTGACCATCCAGTGAACATGATCCTGACCTTTACCTAGGATTCCTCCTGCTCCAAACTTTGCCCATCCTCTTTGCCCCCTCAGGAGTGC
TGAGGGCCAGTGTTGACCCACACTACCCTCCCTTGACCAGCTGTCTGGGACCGGAAACCAGCTTTGTCTCCAGGTAGAGACAACATCCTG
TGACTGCCAGGCAGAAAGGACAGGGCCCAGGTCAGCCTCAGTCTGCTGTGCCTCCAGACTGCAGAGCTCTCAGAACCCAGAACAGAGACG
AAAAGGCTACCTCTCCTACCCAAGTTAAGTGTTCAAAGGGGATGTGAGGGCCTCCACTGAAGCAGGGAGGCAGCTGTGTAATCCTATGTC
AGCTCTCTTAGGAAGCCCCAGTACTTATATTGGGCATGCACTTGCCCTTAAAAACAATGATTTGTGAGTCCAGGAACAATTTACTATTTT
TAAAATATTTTGCTGCTTCTGTTCTGGGTCTGAATTCCCTTTTGTGCCAGATGCCAGTACTGTCTGCCCATTGGCTCCAGGGGCTGTATG
GGCAGATTCAGTCTCCAGAGGGTATTCAGATCATCTGCTTCTTTGAAGGAGTAAATGTGTTTTGTTCCTAGGGCCAGAGGAGCTTGTCTT
CCTTGTCCTCTGTTCCCACCCTCCCCTGAACAGAACCCAGCCCATAAGAGACATTCTCAGATGAAACTCTGTTTTCTTGCCCCAGTCAGG

>52132_52132_2_MCAT-ACSS2_MCAT_chr22_43537167_ENST00000290429_ACSS2_chr20_33513500_ENST00000336325_length(amino acids)=319AA_BP=170
MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVREL
YAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGCQRDQDGYY
WITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAP

--------------------------------------------------------------
>52132_52132_3_MCAT-ACSS2_MCAT_chr22_43537167_ENST00000290429_ACSS2_chr20_33513500_ENST00000360596_length(transcript)=1754nt_BP=557nt
TCGGGCCTCGGTCGCCACGGTAACGCGCGCGGGCAGGTGTCCGACCATGAGCGTCCGGGTCGCACGGGTAGCGTGGGTCAGGGGCTTGGG
CGCCAGCTACCGCCGCGGCGCCTCGAGCTTCCCGGTGCCTCCGCCGGGCGCCCAGGGTGTAGCGGAGCTGCTGCGAGATGCGACCGGGGC
GGAGGAGGAGGCGCCCTGGGCGGCGACGGAGCGGCGAATGCCGGGCCAGTGCTCCGTGCTGCTCTTCCCGGGCCAGGGCAGCCAGGTGGT
GGGCATGGGCCGCGGTCTGCTCAACTACCCGCGCGTCCGCGAACTCTACGCCGCCGCCCGCCGCGTGCTGGGCTACGACCTGCTGGAACT
GAGCCTGCACGGGCCGCAGGAGACCCTGGACCGCACCGTGCACTGTCAGCCCGCGATCTTCGTGGCATCGCTGGCCGCTGTCGAGAAACT
ACATCACCTGCAGCCCTCGGTGATTGAGAACTGTGTTGCTGCTGCTGGATTCAGTGTGGGAGAGTTTGCAGCCCTAGTGTTTGCCGGAGC
CATGGAATTTGCTGAAGGCTGCCAGCGGGACCAGGATGGCTATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTATCTGGACA
CCTGCTGAGTACAGCAGAGGTGGAGTCAGCACTTGTGGAACATGAGGCTGTTGCAGAGGCAGCTGTGGTGGGCCACCCTCATCCTGTGAA
GGGTGAATGCCTCTACTGCTTTGTCACCTTGTGTGATGGCCACACCTTCAGCCCCAAGCTCACCGAGGAGCTCAAGAAGCAGATTAGAGA
AAAGATTGGCCCCATTGCCACACCAGACTACATCCAGAATGCACCTGGCTTGCCTAAAACCCGCTCAGGGAAAATCATGAGGCGAGTGCT
TCGGAAGATTGCTCAGAATGACCATGACCTCGGGGACATGTCTACTGTGGCTGACCCATCTGTCATCAGTCACCTCTTCAGCCACCGCTG
CCTGACCATCCAGTGAACATGATCCTGACCTTTACCTAGGATTCCTCCTGCTCCAAACTTTGCCCATCCTCTTTGCCCCCTCAGGAGTGC
TGAGGGCCAGTGTTGACCCACACTACCCTCCCTTGACCAGCTGTCTGGGACCGGAAACCAGCTTTGTCTCCAGGTAGAGACAACATCCTG
TGACTGCCAGGCAGAAAGGACAGGGCCCAGGTCAGCCTCAGTCTGCTGTGCCTCCAGACTGCAGAGCTCTCAGAACCCAGAACAGAGACG
AAAAGGCTACCTCTCCTACCCAAGTTAAGTGTTCAAAGGGGATGTGAGGGCCTCCACTGAAGCAGGGAGGCAGCTGTGTAATCCTATGTC
AGCTCTCTTAGGAAGCCCCAGTACTTATATTGGGCATGCACTTGCCCTTAAAAACAATGATTTGTGAGTCCAGGAACAATTTACTATTTT
TAAAATATTTTGCTGCTTCTGTTCTGGGTCTGAATTCCCTTTTGTGCCAGATGCCAGTACTGTCTGCCCATTGGCTCCAGGGGCTGTATG
GGCAGATTCAGTCTCCAGAGGGTATTCAGATCATCTGCTTCTTTGAAGGAGTAAATGTGTTTTGTTCCTAGGGCCAGAGGAGCTTGTCTT
CCTTGTCCTCTGTTCCCACCCTCCCCTGAACAGAACCCAGCCCATAAGAGACATTCTCAGATGAAACTCTGTTTTCTTGCCCCAGTCAGG

>52132_52132_3_MCAT-ACSS2_MCAT_chr22_43537167_ENST00000290429_ACSS2_chr20_33513500_ENST00000360596_length(amino acids)=319AA_BP=170
MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVREL
YAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGCQRDQDGYY
WITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAP

--------------------------------------------------------------
>52132_52132_4_MCAT-ACSS2_MCAT_chr22_43537167_ENST00000327555_ACSS2_chr20_33513500_ENST00000253382_length(transcript)=1724nt_BP=527nt
GGGCAGGTGTCCGACCATGAGCGTCCGGGTCGCACGGGTAGCGTGGGTCAGGGGCTTGGGCGCCAGCTACCGCCGCGGCGCCTCGAGCTT
CCCGGTGCCTCCGCCGGGCGCCCAGGGTGTAGCGGAGCTGCTGCGAGATGCGACCGGGGCGGAGGAGGAGGCGCCCTGGGCGGCGACGGA
GCGGCGAATGCCGGGCCAGTGCTCCGTGCTGCTCTTCCCGGGCCAGGGCAGCCAGGTGGTGGGCATGGGCCGCGGTCTGCTCAACTACCC
GCGCGTCCGCGAACTCTACGCCGCCGCCCGCCGCGTGCTGGGCTACGACCTGCTGGAACTGAGCCTGCACGGGCCGCAGGAGACCCTGGA
CCGCACCGTGCACTGTCAGCCCGCGATCTTCGTGGCATCGCTGGCCGCTGTCGAGAAACTACATCACCTGCAGCCCTCGGTGATTGAGAA
CTGTGTTGCTGCTGCTGGATTCAGTGTGGGAGAGTTTGCAGCCCTAGTGTTTGCCGGAGCCATGGAATTTGCTGAAGGCTGCCAGCGGGA
CCAGGATGGCTATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTATCTGGACACCTGCTGAGTACAGCAGAGGTGGAGTCAGC
ACTTGTGGAACATGAGGCTGTTGCAGAGGCAGCTGTGGTGGGCCACCCTCATCCTGTGAAGGGTGAATGCCTCTACTGCTTTGTCACCTT
GTGTGATGGCCACACCTTCAGCCCCAAGCTCACCGAGGAGCTCAAGAAGCAGATTAGAGAAAAGATTGGCCCCATTGCCACACCAGACTA
CATCCAGAATGCACCTGGCTTGCCTAAAACCCGCTCAGGGAAAATCATGAGGCGAGTGCTTCGGAAGATTGCTCAGAATGACCATGACCT
CGGGGACATGTCTACTGTGGCTGACCCATCTGTCATCAGTCACCTCTTCAGCCACCGCTGCCTGACCATCCAGTGAACATGATCCTGACC
TTTACCTAGGATTCCTCCTGCTCCAAACTTTGCCCATCCTCTTTGCCCCCTCAGGAGTGCTGAGGGCCAGTGTTGACCCACACTACCCTC
CCTTGACCAGCTGTCTGGGACCGGAAACCAGCTTTGTCTCCAGGTAGAGACAACATCCTGTGACTGCCAGGCAGAAAGGACAGGGCCCAG
GTCAGCCTCAGTCTGCTGTGCCTCCAGACTGCAGAGCTCTCAGAACCCAGAACAGAGACGAAAAGGCTACCTCTCCTACCCAAGTTAAGT
GTTCAAAGGGGATGTGAGGGCCTCCACTGAAGCAGGGAGGCAGCTGTGTAATCCTATGTCAGCTCTCTTAGGAAGCCCCAGTACTTATAT
TGGGCATGCACTTGCCCTTAAAAACAATGATTTGTGAGTCCAGGAACAATTTACTATTTTTAAAATATTTTGCTGCTTCTGTTCTGGGTC
TGAATTCCCTTTTGTGCCAGATGCCAGTACTGTCTGCCCATTGGCTCCAGGGGCTGTATGGGCAGATTCAGTCTCCAGAGGGTATTCAGA
TCATCTGCTTCTTTGAAGGAGTAAATGTGTTTTGTTCCTAGGGCCAGAGGAGCTTGTCTTCCTTGTCCTCTGTTCCCACCCTCCCCTGAA
CAGAACCCAGCCCATAAGAGACATTCTCAGATGAAACTCTGTTTTCTTGCCCCAGTCAGGCTCAAGCCCTGTGGTTGTAGGAATAAAGCC

>52132_52132_4_MCAT-ACSS2_MCAT_chr22_43537167_ENST00000327555_ACSS2_chr20_33513500_ENST00000253382_length(amino acids)=319AA_BP=170
MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVREL
YAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGCQRDQDGYY
WITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAP

--------------------------------------------------------------
>52132_52132_5_MCAT-ACSS2_MCAT_chr22_43537167_ENST00000327555_ACSS2_chr20_33513500_ENST00000336325_length(transcript)=1728nt_BP=527nt
GGGCAGGTGTCCGACCATGAGCGTCCGGGTCGCACGGGTAGCGTGGGTCAGGGGCTTGGGCGCCAGCTACCGCCGCGGCGCCTCGAGCTT
CCCGGTGCCTCCGCCGGGCGCCCAGGGTGTAGCGGAGCTGCTGCGAGATGCGACCGGGGCGGAGGAGGAGGCGCCCTGGGCGGCGACGGA
GCGGCGAATGCCGGGCCAGTGCTCCGTGCTGCTCTTCCCGGGCCAGGGCAGCCAGGTGGTGGGCATGGGCCGCGGTCTGCTCAACTACCC
GCGCGTCCGCGAACTCTACGCCGCCGCCCGCCGCGTGCTGGGCTACGACCTGCTGGAACTGAGCCTGCACGGGCCGCAGGAGACCCTGGA
CCGCACCGTGCACTGTCAGCCCGCGATCTTCGTGGCATCGCTGGCCGCTGTCGAGAAACTACATCACCTGCAGCCCTCGGTGATTGAGAA
CTGTGTTGCTGCTGCTGGATTCAGTGTGGGAGAGTTTGCAGCCCTAGTGTTTGCCGGAGCCATGGAATTTGCTGAAGGCTGCCAGCGGGA
CCAGGATGGCTATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTATCTGGACACCTGCTGAGTACAGCAGAGGTGGAGTCAGC
ACTTGTGGAACATGAGGCTGTTGCAGAGGCAGCTGTGGTGGGCCACCCTCATCCTGTGAAGGGTGAATGCCTCTACTGCTTTGTCACCTT
GTGTGATGGCCACACCTTCAGCCCCAAGCTCACCGAGGAGCTCAAGAAGCAGATTAGAGAAAAGATTGGCCCCATTGCCACACCAGACTA
CATCCAGAATGCACCTGGCTTGCCTAAAACCCGCTCAGGGAAAATCATGAGGCGAGTGCTTCGGAAGATTGCTCAGAATGACCATGACCT
CGGGGACATGTCTACTGTGGCTGACCCATCTGTCATCAGTCACCTCTTCAGCCACCGCTGCCTGACCATCCAGTGAACATGATCCTGACC
TTTACCTAGGATTCCTCCTGCTCCAAACTTTGCCCATCCTCTTTGCCCCCTCAGGAGTGCTGAGGGCCAGTGTTGACCCACACTACCCTC
CCTTGACCAGCTGTCTGGGACCGGAAACCAGCTTTGTCTCCAGGTAGAGACAACATCCTGTGACTGCCAGGCAGAAAGGACAGGGCCCAG
GTCAGCCTCAGTCTGCTGTGCCTCCAGACTGCAGAGCTCTCAGAACCCAGAACAGAGACGAAAAGGCTACCTCTCCTACCCAAGTTAAGT
GTTCAAAGGGGATGTGAGGGCCTCCACTGAAGCAGGGAGGCAGCTGTGTAATCCTATGTCAGCTCTCTTAGGAAGCCCCAGTACTTATAT
TGGGCATGCACTTGCCCTTAAAAACAATGATTTGTGAGTCCAGGAACAATTTACTATTTTTAAAATATTTTGCTGCTTCTGTTCTGGGTC
TGAATTCCCTTTTGTGCCAGATGCCAGTACTGTCTGCCCATTGGCTCCAGGGGCTGTATGGGCAGATTCAGTCTCCAGAGGGTATTCAGA
TCATCTGCTTCTTTGAAGGAGTAAATGTGTTTTGTTCCTAGGGCCAGAGGAGCTTGTCTTCCTTGTCCTCTGTTCCCACCCTCCCCTGAA
CAGAACCCAGCCCATAAGAGACATTCTCAGATGAAACTCTGTTTTCTTGCCCCAGTCAGGCTCAAGCCCTGTGGTTGTAGGAATAAAGCC

>52132_52132_5_MCAT-ACSS2_MCAT_chr22_43537167_ENST00000327555_ACSS2_chr20_33513500_ENST00000336325_length(amino acids)=319AA_BP=170
MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVREL
YAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGCQRDQDGYY
WITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAP

--------------------------------------------------------------
>52132_52132_6_MCAT-ACSS2_MCAT_chr22_43537167_ENST00000327555_ACSS2_chr20_33513500_ENST00000360596_length(transcript)=1724nt_BP=527nt
GGGCAGGTGTCCGACCATGAGCGTCCGGGTCGCACGGGTAGCGTGGGTCAGGGGCTTGGGCGCCAGCTACCGCCGCGGCGCCTCGAGCTT
CCCGGTGCCTCCGCCGGGCGCCCAGGGTGTAGCGGAGCTGCTGCGAGATGCGACCGGGGCGGAGGAGGAGGCGCCCTGGGCGGCGACGGA
GCGGCGAATGCCGGGCCAGTGCTCCGTGCTGCTCTTCCCGGGCCAGGGCAGCCAGGTGGTGGGCATGGGCCGCGGTCTGCTCAACTACCC
GCGCGTCCGCGAACTCTACGCCGCCGCCCGCCGCGTGCTGGGCTACGACCTGCTGGAACTGAGCCTGCACGGGCCGCAGGAGACCCTGGA
CCGCACCGTGCACTGTCAGCCCGCGATCTTCGTGGCATCGCTGGCCGCTGTCGAGAAACTACATCACCTGCAGCCCTCGGTGATTGAGAA
CTGTGTTGCTGCTGCTGGATTCAGTGTGGGAGAGTTTGCAGCCCTAGTGTTTGCCGGAGCCATGGAATTTGCTGAAGGCTGCCAGCGGGA
CCAGGATGGCTATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTATCTGGACACCTGCTGAGTACAGCAGAGGTGGAGTCAGC
ACTTGTGGAACATGAGGCTGTTGCAGAGGCAGCTGTGGTGGGCCACCCTCATCCTGTGAAGGGTGAATGCCTCTACTGCTTTGTCACCTT
GTGTGATGGCCACACCTTCAGCCCCAAGCTCACCGAGGAGCTCAAGAAGCAGATTAGAGAAAAGATTGGCCCCATTGCCACACCAGACTA
CATCCAGAATGCACCTGGCTTGCCTAAAACCCGCTCAGGGAAAATCATGAGGCGAGTGCTTCGGAAGATTGCTCAGAATGACCATGACCT
CGGGGACATGTCTACTGTGGCTGACCCATCTGTCATCAGTCACCTCTTCAGCCACCGCTGCCTGACCATCCAGTGAACATGATCCTGACC
TTTACCTAGGATTCCTCCTGCTCCAAACTTTGCCCATCCTCTTTGCCCCCTCAGGAGTGCTGAGGGCCAGTGTTGACCCACACTACCCTC
CCTTGACCAGCTGTCTGGGACCGGAAACCAGCTTTGTCTCCAGGTAGAGACAACATCCTGTGACTGCCAGGCAGAAAGGACAGGGCCCAG
GTCAGCCTCAGTCTGCTGTGCCTCCAGACTGCAGAGCTCTCAGAACCCAGAACAGAGACGAAAAGGCTACCTCTCCTACCCAAGTTAAGT
GTTCAAAGGGGATGTGAGGGCCTCCACTGAAGCAGGGAGGCAGCTGTGTAATCCTATGTCAGCTCTCTTAGGAAGCCCCAGTACTTATAT
TGGGCATGCACTTGCCCTTAAAAACAATGATTTGTGAGTCCAGGAACAATTTACTATTTTTAAAATATTTTGCTGCTTCTGTTCTGGGTC
TGAATTCCCTTTTGTGCCAGATGCCAGTACTGTCTGCCCATTGGCTCCAGGGGCTGTATGGGCAGATTCAGTCTCCAGAGGGTATTCAGA
TCATCTGCTTCTTTGAAGGAGTAAATGTGTTTTGTTCCTAGGGCCAGAGGAGCTTGTCTTCCTTGTCCTCTGTTCCCACCCTCCCCTGAA
CAGAACCCAGCCCATAAGAGACATTCTCAGATGAAACTCTGTTTTCTTGCCCCAGTCAGGCTCAAGCCCTGTGGTTGTAGGAATAAAGCC

>52132_52132_6_MCAT-ACSS2_MCAT_chr22_43537167_ENST00000327555_ACSS2_chr20_33513500_ENST00000360596_length(amino acids)=319AA_BP=170
MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVREL
YAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGCQRDQDGYY
WITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MCAT-ACSS2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MCAT-ACSS2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MCAT-ACSS2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source