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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MCCC1-FXR1 (FusionGDB2 ID:52136)

Fusion Gene Summary for MCCC1-FXR1

check button Fusion gene summary
Fusion gene informationFusion gene name: MCCC1-FXR1
Fusion gene ID: 52136
HgeneTgene
Gene symbol

MCCC1

FXR1

Gene ID

56922

8087

Gene namemethylcrotonoyl-CoA carboxylase 1FMR1 autosomal homolog 1
SynonymsMCC-B|MCCAFXR1P
Cytomap

3q27.1

3q26.33

Type of geneprotein-codingprotein-coding
Descriptionmethylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial3-methylcrotonyl-CoA carboxylase 13-methylcrotonyl-CoA carboxylase biotin-containing subunit3-methylcrotonyl-CoA:carbon dioxide ligase subunit alphaMCCase subunit alphamethylcrotonoyl-CoA cafragile X mental retardation syndrome-related protein 1fragile X mental retardation, autosomal homolog 1
Modification date2020031320200320
UniProtAcc

Q96RQ3

P51114

Ensembl transtripts involved in fusion geneENST00000265594, ENST00000492597, 
ENST00000539926, ENST00000489909, 
ENST00000445140, ENST00000468861, 
ENST00000480918, ENST00000491062, 
ENST00000491674, ENST00000305586, 
ENST00000357559, 
Fusion gene scores* DoF score10 X 12 X 6=7209 X 11 X 4=396
# samples 1411
** MAII scorelog2(14/720*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MCCC1 [Title/Abstract] AND FXR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMCCC1(182788787)-FXR1(180679256), # samples:3
FXR1(180630524)-MCCC1(182790275), # samples:4
Anticipated loss of major functional domain due to fusion event.MCCC1-FXR1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MCCC1-FXR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MCCC1-FXR1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFXR1

GO:2000637

positive regulation of gene silencing by miRNA

17057366


check buttonFusion gene breakpoints across MCCC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FXR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-7223-01AMCCC1chr3

182788787

-FXR1chr3

180679256

+
ChimerDB4LUSCTCGA-56-7223MCCC1chr3

182788786

-FXR1chr3

180679255

+
ChimerDB4LUSCTCGA-56-7223MCCC1chr3

182788787

-FXR1chr3

180679256

+


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Fusion Gene ORF analysis for MCCC1-FXR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265594ENST00000445140MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000265594ENST00000445140MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000265594ENST00000468861MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000265594ENST00000468861MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000265594ENST00000480918MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000265594ENST00000480918MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000265594ENST00000491062MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000265594ENST00000491062MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000265594ENST00000491674MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000265594ENST00000491674MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000492597ENST00000445140MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000492597ENST00000445140MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000492597ENST00000468861MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000492597ENST00000468861MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000492597ENST00000480918MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000492597ENST00000480918MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000492597ENST00000491062MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000492597ENST00000491062MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000492597ENST00000491674MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000492597ENST00000491674MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000539926ENST00000445140MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000539926ENST00000445140MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000539926ENST00000468861MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000539926ENST00000468861MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000539926ENST00000480918MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000539926ENST00000480918MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000539926ENST00000491062MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000539926ENST00000491062MCCC1chr3

182788786

-FXR1chr3

180679255

+
5CDS-intronENST00000539926ENST00000491674MCCC1chr3

182788787

-FXR1chr3

180679256

+
5CDS-intronENST00000539926ENST00000491674MCCC1chr3

182788786

-FXR1chr3

180679255

+
Frame-shiftENST00000265594ENST00000305586MCCC1chr3

182788787

-FXR1chr3

180679256

+
Frame-shiftENST00000265594ENST00000305586MCCC1chr3

182788786

-FXR1chr3

180679255

+
Frame-shiftENST00000265594ENST00000357559MCCC1chr3

182788787

-FXR1chr3

180679256

+
Frame-shiftENST00000265594ENST00000357559MCCC1chr3

182788786

-FXR1chr3

180679255

+
Frame-shiftENST00000492597ENST00000305586MCCC1chr3

182788787

-FXR1chr3

180679256

+
Frame-shiftENST00000492597ENST00000305586MCCC1chr3

182788786

-FXR1chr3

180679255

+
Frame-shiftENST00000492597ENST00000357559MCCC1chr3

182788787

-FXR1chr3

180679256

+
Frame-shiftENST00000492597ENST00000357559MCCC1chr3

182788786

-FXR1chr3

180679255

+
In-frameENST00000539926ENST00000305586MCCC1chr3

182788787

-FXR1chr3

180679256

+
In-frameENST00000539926ENST00000305586MCCC1chr3

182788786

-FXR1chr3

180679255

+
In-frameENST00000539926ENST00000357559MCCC1chr3

182788787

-FXR1chr3

180679256

+
In-frameENST00000539926ENST00000357559MCCC1chr3

182788786

-FXR1chr3

180679255

+
intron-3CDSENST00000489909ENST00000305586MCCC1chr3

182788787

-FXR1chr3

180679256

+
intron-3CDSENST00000489909ENST00000305586MCCC1chr3

182788786

-FXR1chr3

180679255

+
intron-3CDSENST00000489909ENST00000357559MCCC1chr3

182788787

-FXR1chr3

180679256

+
intron-3CDSENST00000489909ENST00000357559MCCC1chr3

182788786

-FXR1chr3

180679255

+
intron-intronENST00000489909ENST00000445140MCCC1chr3

182788787

-FXR1chr3

180679256

+
intron-intronENST00000489909ENST00000445140MCCC1chr3

182788786

-FXR1chr3

180679255

+
intron-intronENST00000489909ENST00000468861MCCC1chr3

182788787

-FXR1chr3

180679256

+
intron-intronENST00000489909ENST00000468861MCCC1chr3

182788786

-FXR1chr3

180679255

+
intron-intronENST00000489909ENST00000480918MCCC1chr3

182788787

-FXR1chr3

180679256

+
intron-intronENST00000489909ENST00000480918MCCC1chr3

182788786

-FXR1chr3

180679255

+
intron-intronENST00000489909ENST00000491062MCCC1chr3

182788787

-FXR1chr3

180679256

+
intron-intronENST00000489909ENST00000491062MCCC1chr3

182788786

-FXR1chr3

180679255

+
intron-intronENST00000489909ENST00000491674MCCC1chr3

182788787

-FXR1chr3

180679256

+
intron-intronENST00000489909ENST00000491674MCCC1chr3

182788786

-FXR1chr3

180679255

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000539926MCCC1chr3182788787-ENST00000357559FXR1chr3180679256+79436066091481290
ENST00000539926MCCC1chr3182788787-ENST00000305586FXR1chr3180679256+23456066091481290
ENST00000539926MCCC1chr3182788786-ENST00000357559FXR1chr3180679255+79436066091481290
ENST00000539926MCCC1chr3182788786-ENST00000305586FXR1chr3180679255+23456066091481290

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000539926ENST00000357559MCCC1chr3182788787-FXR1chr3180679256+0.0002629130.9997371
ENST00000539926ENST00000305586MCCC1chr3182788787-FXR1chr3180679256+0.0007306190.9992694
ENST00000539926ENST00000357559MCCC1chr3182788786-FXR1chr3180679255+0.0002629130.9997371
ENST00000539926ENST00000305586MCCC1chr3182788786-FXR1chr3180679255+0.0007306190.9992694

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Fusion Genomic Features for MCCC1-FXR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MCCC1-FXR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:182788787/chr3:180679256)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MCCC1

Q96RQ3

FXR1

P51114

FUNCTION: Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195}.FUNCTION: RNA-binding protein required for embryonic and postnatal development of muscle tissue (PubMed:30770808). May regulate intracellular transport and local translation of certain mRNAs (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:30770808}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFXR1chr3:182788786chr3:180679255ENST000003055861018502_510245537.0Compositional biasNote=Poly-Arg
TgeneFXR1chr3:182788786chr3:180679255ENST00000357559917502_510330622.0Compositional biasNote=Poly-Arg
TgeneFXR1chr3:182788786chr3:180679255ENST00000445140916502_510330540.0Compositional biasNote=Poly-Arg
TgeneFXR1chr3:182788787chr3:180679256ENST000003055861018502_510245537.0Compositional biasNote=Poly-Arg
TgeneFXR1chr3:182788787chr3:180679256ENST00000357559917502_510330622.0Compositional biasNote=Poly-Arg
TgeneFXR1chr3:182788787chr3:180679256ENST00000445140916502_510330540.0Compositional biasNote=Poly-Arg
TgeneFXR1chr3:182788786chr3:180679255ENST000003055861018285_314245537.0DomainKH 2
TgeneFXR1chr3:182788787chr3:180679256ENST000003055861018285_314245537.0DomainKH 2
TgeneFXR1chr3:182788786chr3:180679255ENST000003055861018442_457245537.0RegionNote=RNA-binding RGG-box
TgeneFXR1chr3:182788786chr3:180679255ENST00000357559917442_457330622.0RegionNote=RNA-binding RGG-box
TgeneFXR1chr3:182788786chr3:180679255ENST00000445140916442_457330540.0RegionNote=RNA-binding RGG-box
TgeneFXR1chr3:182788787chr3:180679256ENST000003055861018442_457245537.0RegionNote=RNA-binding RGG-box
TgeneFXR1chr3:182788787chr3:180679256ENST00000357559917442_457330622.0RegionNote=RNA-binding RGG-box
TgeneFXR1chr3:182788787chr3:180679256ENST00000445140916442_457330540.0RegionNote=RNA-binding RGG-box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCCC1chr3:182788786chr3:180679255ENST00000265594-719167_364253726.0DomainATP-grasp
HgeneMCCC1chr3:182788786chr3:180679255ENST00000265594-71948_494253726.0DomainNote=Biotin carboxylation
HgeneMCCC1chr3:182788786chr3:180679255ENST00000265594-719643_715253726.0DomainBiotinyl-binding
HgeneMCCC1chr3:182788787chr3:180679256ENST00000265594-719167_364253726.0DomainATP-grasp
HgeneMCCC1chr3:182788787chr3:180679256ENST00000265594-71948_494253726.0DomainNote=Biotin carboxylation
HgeneMCCC1chr3:182788787chr3:180679256ENST00000265594-719643_715253726.0DomainBiotinyl-binding
TgeneFXR1chr3:182788786chr3:180679255ENST00000305586101850_53245537.0Compositional biasNote=Poly-Pro
TgeneFXR1chr3:182788786chr3:180679255ENST0000035755991750_53330622.0Compositional biasNote=Poly-Pro
TgeneFXR1chr3:182788786chr3:180679255ENST0000044514091650_53330540.0Compositional biasNote=Poly-Pro
TgeneFXR1chr3:182788787chr3:180679256ENST00000305586101850_53245537.0Compositional biasNote=Poly-Pro
TgeneFXR1chr3:182788787chr3:180679256ENST0000035755991750_53330622.0Compositional biasNote=Poly-Pro
TgeneFXR1chr3:182788787chr3:180679256ENST0000044514091650_53330540.0Compositional biasNote=Poly-Pro
TgeneFXR1chr3:182788786chr3:180679255ENST000003055861018222_251245537.0DomainKH 1
TgeneFXR1chr3:182788786chr3:180679255ENST0000030558610184_50245537.0DomainAgenet-like 1
TgeneFXR1chr3:182788786chr3:180679255ENST00000305586101863_115245537.0DomainAgenet-like 2
TgeneFXR1chr3:182788786chr3:180679255ENST00000357559917222_251330622.0DomainKH 1
TgeneFXR1chr3:182788786chr3:180679255ENST00000357559917285_314330622.0DomainKH 2
TgeneFXR1chr3:182788786chr3:180679255ENST000003575599174_50330622.0DomainAgenet-like 1
TgeneFXR1chr3:182788786chr3:180679255ENST0000035755991763_115330622.0DomainAgenet-like 2
TgeneFXR1chr3:182788786chr3:180679255ENST00000445140916222_251330540.0DomainKH 1
TgeneFXR1chr3:182788786chr3:180679255ENST00000445140916285_314330540.0DomainKH 2
TgeneFXR1chr3:182788786chr3:180679255ENST000004451409164_50330540.0DomainAgenet-like 1
TgeneFXR1chr3:182788786chr3:180679255ENST0000044514091663_115330540.0DomainAgenet-like 2
TgeneFXR1chr3:182788787chr3:180679256ENST000003055861018222_251245537.0DomainKH 1
TgeneFXR1chr3:182788787chr3:180679256ENST0000030558610184_50245537.0DomainAgenet-like 1
TgeneFXR1chr3:182788787chr3:180679256ENST00000305586101863_115245537.0DomainAgenet-like 2
TgeneFXR1chr3:182788787chr3:180679256ENST00000357559917222_251330622.0DomainKH 1
TgeneFXR1chr3:182788787chr3:180679256ENST00000357559917285_314330622.0DomainKH 2
TgeneFXR1chr3:182788787chr3:180679256ENST000003575599174_50330622.0DomainAgenet-like 1
TgeneFXR1chr3:182788787chr3:180679256ENST0000035755991763_115330622.0DomainAgenet-like 2
TgeneFXR1chr3:182788787chr3:180679256ENST00000445140916222_251330540.0DomainKH 1
TgeneFXR1chr3:182788787chr3:180679256ENST00000445140916285_314330540.0DomainKH 2
TgeneFXR1chr3:182788787chr3:180679256ENST000004451409164_50330540.0DomainAgenet-like 1
TgeneFXR1chr3:182788787chr3:180679256ENST0000044514091663_115330540.0DomainAgenet-like 2


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Fusion Gene Sequence for MCCC1-FXR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52136_52136_1_MCCC1-FXR1_MCCC1_chr3_182788786_ENST00000539926_FXR1_chr3_180679255_ENST00000305586_length(transcript)=2345nt_BP=606nt
AGTGGAGGAACGGGTTTGGCGTGTGGGACGCAGCTGCCTCTGTACTGGGGAGTCACGGAGTGGCCGGGCTCCAGGGACATGGCGGCGGCC
TCTGCGGTGTCGGTGCTGCTGGTGGCGGCGGAGAGGAACCGGTGGCATCGTCTCCCGAGCCTGCTCCTGCCGCCGAGGACATGGGTGTGG
AGGCAAAGAACCATGAAGTACACAACAGCCACAGGCTATCCATCCAGGATGCGGTTTTCTCTCAGAAAACATGGAATTTGCTGAACTTTG
TAAGCAAGAAGGAATTATTTTTATAGGCCCTCCTCCATCTGCAATTAGAGACATGGGTATAAAGAGCACATCCAAATCCATAATGGCTGC
TGCTGGAGTACCTGTTGTGGAGGGTTATCATGGTGAGGACCAATCAGACCAGTGCCTGAAGGAACACGCCAGGAGAATTGGCTATCCTGT
CATGATTAAAGCCGTCCGGGGTGGAGGAGGAAAAGGAATGAGGATTGTTAGATCAGAACAAGAATTTCAAGAACAGTTAGAGTCAGCACG
GAGAGAAGCTAAGAAGTCTTTCAATGATGATGCTATGCTGATCGAGAAGTTTGTAGACACACCGAGGGTATGGTTCCATTTGTATTTGTT
GGCACTAAAGAAAGCATTGGAAATGTGCAGGTTCTTCTAGAGTATCATATTGCCTATCTAAAGGAAGTAGAACAGCTAAGAATGGAACGC
CTACAGATTGATGAACAGCTGCGACAGATTGGTTCTAGGTCTTATAGCGGAAGAGGCAGAGGTCGTCGGGGACCTAATTACACCTCCGGT
TATGGTACAAATTCTGAGCTGTCTAACCCCTCTGAAACGGAATCTGAGCGTAAAGACGAGCTGAGTGATTGGTCATTGGCAGGAGAAGAT
GATCGAGACAGCCGACATCAGCGTGACAGCAGGAGACGCCCAGGAGGAAGAGGCAGAAGTGTTTCAGGGGGTCGAGGTCGTGGTGGACCA
CGTGGTGGCAAATCCTCCATCAGTTCTGTGCTCAAAGATCCAGACAGCAATCCATACAGCTTACTTGATAATACAGAATCAGATCAGACT
GCAGACACTGATGCCAGCGAATCTCATCACAGTACTAACCGTCGTAGGCGGTCTCGTAGACGAAGGACTGATGAAGATGCTGTTCTGATG
GATGGAATGACTGAATCTGATACAGCTTCAGTTAATGAAAATGGGCTAGTCACAGTTGCAGATTATATTTCTAGAGCTGAGTCTCAGAGC
AGACAAAGAAACCTCCCAAGGGAAACTTTGGCTAAAAACAAGAAAGAAATGGCAAAAGATGTGATTGAAGAGCATGGTCCTTCAGAAAAG
GCAATAAACGGCCCAACTAGTGCTTCTGGCGATGACATTTCTAAGCTACAGCGTACTCCAGGAGAAGAAAAGATTAATACCTTAAAAGAA
GAAAACACTCAAGAAGCAGCAGTCCTGAATGGTGTTTCATAAACTGAAGAAGTTCCTAGTTTACAGTTCTTTTACATTACATTTACAATA
GTGCTTGTACAAGCTTGCCAAAGATAGAATATGGATCGCCAGTCTTTACATCGCACTTTCAGTTCCTCCATTTGGAATTCAAAAAGGGGA
GGGATCCTGAAGAAATCATATGTTAAACATACTTTGACACCTACTGTGTTATAAAATATATCATCAGATGTGCCTTGAGAATAGTATATG
TAACATTAAAAAAAAGTTGCTGGCTATAGGAAATGTTATTTTGTTTTCAAAATATGGCAGAGATGGGGGGTGGTGGGTGGGGTGGGATCC
CTAACGTAATATTCTTTATGAAAGCATTAGCTGCTTTTGTTACATTTTTAATATGCAACCACTTCTTCACCTGAGGAAAACTAGAATGAA
ATGCAGTCTAAAATATTTTGCACTGAATTGTAATTTCTTCATTAGTTTAGTCTGGAAACTGGTCTGTTTTAATGTGTTTTTTAAATGCTG
TATGTAGAGGAAAATCTGCAGACCACTGGAATACATTTGTTAAACTCTCATCTGCAGGGACACTGGGCGATACTTGGCAGTGACTGTTCT
ACCTTGAGGCTTTGTTTGGTTTATTTATTAAAGTGTACAGTATTTAAAAATCAAACATAGCTTTAGTTAAAACACTAAGCTGAATTAGTC
ATGTCCATTCAGACATAACCTGAACTACTGAAAAGATCAATTTCCAGAAGGTTTATTCTGTATAAACTACATGTTAGTCTTCAGTAGAGT
ATCTTTTTTTTTTCCTTTTTTTTTTTTTTATTTCGGTTGTTTGATGTGCAATATGTTTTTGTATGCAGGTAGTAAATAAACTTTGATCTT

>52136_52136_1_MCCC1-FXR1_MCCC1_chr3_182788786_ENST00000539926_FXR1_chr3_180679255_ENST00000305586_length(amino acids)=290AA_BP=0
MVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSD
WSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRT
DEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEE

--------------------------------------------------------------
>52136_52136_2_MCCC1-FXR1_MCCC1_chr3_182788786_ENST00000539926_FXR1_chr3_180679255_ENST00000357559_length(transcript)=7943nt_BP=606nt
AGTGGAGGAACGGGTTTGGCGTGTGGGACGCAGCTGCCTCTGTACTGGGGAGTCACGGAGTGGCCGGGCTCCAGGGACATGGCGGCGGCC
TCTGCGGTGTCGGTGCTGCTGGTGGCGGCGGAGAGGAACCGGTGGCATCGTCTCCCGAGCCTGCTCCTGCCGCCGAGGACATGGGTGTGG
AGGCAAAGAACCATGAAGTACACAACAGCCACAGGCTATCCATCCAGGATGCGGTTTTCTCTCAGAAAACATGGAATTTGCTGAACTTTG
TAAGCAAGAAGGAATTATTTTTATAGGCCCTCCTCCATCTGCAATTAGAGACATGGGTATAAAGAGCACATCCAAATCCATAATGGCTGC
TGCTGGAGTACCTGTTGTGGAGGGTTATCATGGTGAGGACCAATCAGACCAGTGCCTGAAGGAACACGCCAGGAGAATTGGCTATCCTGT
CATGATTAAAGCCGTCCGGGGTGGAGGAGGAAAAGGAATGAGGATTGTTAGATCAGAACAAGAATTTCAAGAACAGTTAGAGTCAGCACG
GAGAGAAGCTAAGAAGTCTTTCAATGATGATGCTATGCTGATCGAGAAGTTTGTAGACACACCGAGGGTATGGTTCCATTTGTATTTGTT
GGCACTAAAGAAAGCATTGGAAATGTGCAGGTTCTTCTAGAGTATCATATTGCCTATCTAAAGGAAGTAGAACAGCTAAGAATGGAACGC
CTACAGATTGATGAACAGCTGCGACAGATTGGTTCTAGGTCTTATAGCGGAAGAGGCAGAGGTCGTCGGGGACCTAATTACACCTCCGGT
TATGGTACAAATTCTGAGCTGTCTAACCCCTCTGAAACGGAATCTGAGCGTAAAGACGAGCTGAGTGATTGGTCATTGGCAGGAGAAGAT
GATCGAGACAGCCGACATCAGCGTGACAGCAGGAGACGCCCAGGAGGAAGAGGCAGAAGTGTTTCAGGGGGTCGAGGTCGTGGTGGACCA
CGTGGTGGCAAATCCTCCATCAGTTCTGTGCTCAAAGATCCAGACAGCAATCCATACAGCTTACTTGATAATACAGAATCAGATCAGACT
GCAGACACTGATGCCAGCGAATCTCATCACAGTACTAACCGTCGTAGGCGGTCTCGTAGACGAAGGACTGATGAAGATGCTGTTCTGATG
GATGGAATGACTGAATCTGATACAGCTTCAGTTAATGAAAATGGGCTAGTCACAGTTGCAGATTATATTTCTAGAGCTGAGTCTCAGAGC
AGACAAAGAAACCTCCCAAGGGAAACTTTGGCTAAAAACAAGAAAGAAATGGCAAAAGATGTGATTGAAGAGCATGGTCCTTCAGAAAAG
GCAATAAACGGCCCAACTAGTGCTTCTGGCGATGACATTTCTAAGCTACAGCGTACTCCAGGAGAAGAAAAGATTAATACCTTAAAAGAA
GAAAACACTCAAGAAGCAGCAGTCCTGAATGGTGTTTCATAAACTGAAGAAGTTCCTAGTTTACAGTTCTTTTACATTACATTTACAATA
GTGCTTGTACAAGCTTGCCAAAGATAGAATATGGATCGCCAGTCTTTACATCGCACTTTCAGTTCCTCCATTTGGAATTCAAAAAGGGGA
GGGATCCTGAAGAAATCATATGTTAAACATACTTTGACACCTACTGTGTTATAAAATATATCATCAGATGTGCCTTGAGAATAGTATATG
TAACATTAAAAAAAAGTTGCTGGCTATAGGAAATGTTATTTTGTTTTCAAAATATGGCAGAGATGGGGGGTGGTGGGTGGGGTGGGATCC
CTAACGTAATATTCTTTATGAAAGCATTAGCTGCTTTTGTTACATTTTTAATATGCAACCACTTCTTCACCTGAGGAAAACTAGAATGAA
ATGCAGTCTAAAATATTTTGCACTGAATTGTAATTTCTTCATTAGTTTAGTCTGGAAACTGGTCTGTTTTAATGTGTTTTTTAAATGCTG
TATGTAGAGGAAAATCTGCAGACCACTGGAATACATTTGTTAAACTCTCATCTGCAGGGACACTGGGCGATACTTGGCAGTGACTGTTCT
ACCTTGAGGCTTTGTTTGGTTTATTTATTAAAGTGTACAGTATTTAAAAATCAAACATAGCTTTAGTTAAAACACTAAGCTGAATTAGTC
ATGTCCATTCAGACATAACCTGAACTACTGAAAAGATCAATTTCCAGAAGGTTTATTCTGTATAAACTACATGTTAGTCTTCAGTAGAGT
ATCTTTTTTTTTTCCTTTTTTTTTTTTTTATTTCGGTTGTTTGATGTGCAATATGTTTTTGTATGCAGGTAGTAAATAAACTTTGATCTT
CCATTTGCTGAATTTTTTTAACTTTCTACTTTTTACACCAATTGTTGCAAAATAGTTGGAGCTATTAATAGGCTTAGGATAGTATACTTT
GCTTTTTAAAAAGCATTTATACTTGCTCATAAATAGCATTAAAATGTCAGTTGGCCATTTAATCATTTTGTAATGAATCATCTGAAATCT
TTACACAAGTTTAGGCTGTTAGATGCATAGGTAATTAATAATACATGTGATAATTAGCAAAAAAACCTAACAAAATTCTAATCAAAGGCA
ACTTTGGAAGACAATGGGGGATAGAAGGGATGACAAGCAATTTTTAAATAATAGGCCAATGATTTGCTTTATTCATTCTCAACTTATTTT
GAAGGCTCTCATATCAGTGACCAAAAATCAGTTATTAAACTTTATGTATATATTTTAGCCAGAGCTTAATTTTTATGAAGATAAAGACAT
GAAGTTTAACAATGGACAACAGTTAGTACAGCTAATTGTGAGGTCAAGTAATTGTTAGACATAGGGGAAGGCTTTGTTCCACAATATTAT
ATGGACCACTGAACAAGAATGACAGCCCTTTGTTATCACTTGGCATATGAAAAGTGTTGTGTGCATAGTTTGTGTTAATTTTTTATGTGC
ATAAAAATGTGATTTTAATTTATATGCTCTGAAGGATAATTCAGGGTATAGTTAAAAATGTACAATGTGCCAGTTCAGTATATATAACCC
TAGCCCTCAAATTATTCTGATTAAGGTTAAAATGTGCTGGTATTACGTGCTTTTTCCTGAGGCCTTCTGATTGGTTCTTGGTAACAGAAT
TTTAAAGTAAGGTGTGAGTAGTGCAACTCCTGTCCTTTATATATAAAGATATCAAGTAATTTCATGTCCTGATATTTAAAAAAATTACCC
ACAAATGTGTTTTTTTAAATCGATCAAAGCTAGCAACAGGTTAAATTGTCTCAGTTCTCTTACATAATTGGGTTAAAAATTATAAGGTAT
TAGAAGAATTTTAATTAATGCCAAATTGGTAAATATGGTGTAAAAAAAAAAAAAAAGACTTTTCATTTTCTCCCACATAGAATAGTCAGA
TATATTAAACATCCCTTTTCCATAAAGATGGTTTCAATGGGAATGGAAGAAACAAAATCTTAAAAGAGTGAGTATAGCTGAACCAATTCT
TCATTCTAGCAATAACCACACTAAGTTCATTACTTTACAAATGACTAAACCCAATGTCTTGTCCTTTAAAAAATATAGGTAGTGCAGAAT
TGTGATAAATACGCATTTGTTTTTTTAGAGAGCCCCACTCCCCAAAGGGTAGCCATTAATTCAGGTAGCCTTTTAAATGTATTTGAGAGG
GTTCCGTCTTTTTGGCTGCTATCCTAGTTAGGTGAGATGTTGCTATGGGAAGAACTTGCCACTATACACTAAACAGACACTTAAGCAAAA
GATGTATTCTGGAGCCTGGCACAGTAGCTTATGTCTTTGGTTCTAGCTACTCAGGAGCCTGAGGTGGGAGCATCATTTGAACTCAGTTCT
GGGCCACTGAGACCCTCTTTAAAGAGAAGGAAAAAAAGGTATTCTGGAAGATCTTGTGCAGTTGCAACAATGTTTCAGCATATATATGTG
AATTCATATATGACACCTGAACGGAATCATGAAGTAACAGCTGAGATTATATGGTGGCAAAAATGACCTGCTTTTCCTGAAGCTTTGGGA
GGCCTAGGATTCTTGCTTTAGGCATCACCTTTGTTAAGCCTTAAAGGGGGCTACAACTTGTGCAAAATGGTGTCTCTGGTAACACTTCAG
AAATAATTGGCAAAAGTGTAATAGGAATACACAAATCTTTATTTTGAAATAATCTTGTATTTTAATGTGGAATTAGAAGCAGCACATCAA
ACTGGTGAGTTCACAGAAACTTACCTGAGATGATGCTGGGTTCCATTGCTGTTGTGCTAAGTCACGTATTTTTGTAGCTGCTGTTAGCTG
TGTCTAGCGTTTTGTAACCTAAGGAGGGTCTTATAGAAGTTGGTATGTTAACTAAATCTTGGACTGGGAAACAGCACCATTTGTATCCTC
TGCAAACAGATTTACGCTTTTGAGGCTCAAACCAACTAGTGTTCTCATGGGCTGTTGCCTAAGGACAGATAAACATGGAAAACAGGCTAT
GTCCAGGGACAGATGATTGGTGGTTAAGAATTACAGTAAAGGAAAATTACACCTGGATTTTCTTCTGTAAAGTTTCAAGGAACTTGGATT
TGAACTGTGAATCTACTGTTTTGGCAAAAAATCTCAAAGAAAAGGATGTTTGTTACTGTCTCAGTCTTCCTGTCTTTGCTACACGATTTG
GATCCCTTACGCTTTTTCGTTAAGAATATCTGTCTGCTATAGTGAATTTGCTAGCCCCTTATTTTTTTTTTTAATTTTAGTTCTTTATTA
GAACGTGTACTTGAATGGACTGTAGTTGCTCATAACCCATGTTAATCTCTGATAGTATTTGGGTTTTATTTCAGGAGCTTTTGCAATAAA
GCAGTAACTGCAATCTGCTAAAGTCAGACTGTTAGCAAGTGGTGTTAAAACTGATTTAAGTCCATTACACTGAACAGTAGGAAATTACCA
CTTTTGTAAGGCTCAAAAATGATCAACTATTAACAGTTTCTTATGGTTCAGTCTAATTACAAATTTTTAAAAAGTTTATCAGTGTATCAT
TTCAGATTCATCTGTATCTTCTGTAATATTATTTCCAGTACTGAGGTAAGGTACACAAAAATTCCCCTGGAAAAACTATATTCTAGTTTT
GTAAGATGATTTCCCACAGTCCATTTGCTTATTTCTTCCTTTGATAATTCAAAAAGATGCTTTAGGTAATGGTACAGAATTAGAAGCTGC
TATTTTAGCTCTATTAACTTTTTCTCTATGGTTTCAATTTTATCCAACCAGAGAGGGCTGGCCTAGTTGGTATCTTTAAGGCCCTTCCAG
TAGTAATTTGAGTCTAGTCACATGTCAGACCCTGAGCAACACCTAACCAAATGCCCAAGTATTCTCATAAGGAGTATGCTGAATTTAAGT
GGTGTTTGTTTTACATATGTATCCATCCCAGACATTTTCAACTATGCTGAATGCAATCTATAAGATATTCCAAACAAGGACAAAGTAATT
TTTCACAAGTCTTACAGCCCCACTATTAAGTATGCTACTAATTAGCTTCTTGAATTTCTTTGTATTTCAGTGATTGGGATGTTCTTTTTT
TTTGGGAAAGTTTTTTTACCCCTTTGTACCCTCTTAATTGGATTAACTGTAAAATGTACATATTAATTTTCTAGTTTTAGAGACCATTTT
CATTAAAAATATTTTCCAATAGTTTTTCTAGATAAACAATTTATACTTAATTGTTGCTTGGTTGCTTACATTTCAACCTCTAGGCTTCCT
TTTTCAGCTAACTTGGCTGTCTTCAGGTTGTAAAGAAAAATGTAAACATATATTTGAAATTTCATTAACTGAAACTGCTGTAAGGTGTTA
GCAAATGTTAACCATAACAGATTATCCCATATCATTGGACTGTTCTATTATTGGGTCAGGAATAATAGGTGACACAGGATAGAAGCTCTT
CCTATATATATCTTGTTGCTAAGGCAGTAGTTGGCTCTAAGCTGATAAACAGCACACTGTACAGCAGTCCAAAAACTAAAACCAGAGCTT
AGGTCATTCAAGTTAACTGGTACTCAAGGTTACTCATTCCAGGATACTTTACATAACCAAAAACCTAGGAGAGCATTCTACATTGTAATT
TTTTTTTTACTTTGTTTACATAAAATTTACAGGGTTTTGTTTTTTTAAGCTTAGTCTGTTCTTTGACATTGTTGATTCATGTTCTAAATT
TTCATCAGATTTAACATGTTTGGAGGTTCTTGTGCACTCAATGTGAACCTACTACAAGCTTCTGAACTGCAAAACCTTTTTTTTAGGTCA
CTGTCAACAGAAAGATGCCTTATAGAATTTCTCATGATTGAAACAGAACTCTGCATTCTAACCTAAAACCCCTCTAACCCTTTAAATGAA
GCATTATGCCTGCGTGAAATTTTATTTTTAGACATTTCTGATACTAGGTTTTCTTTACGGGGGGGCATACATATTCAGTATACTGAATTT
ATACAGCTTTCAGTGTGGCAATATATTAAGAAGCTAGTTCCCTAATTTTTCTCAGTTCTCATTGGTTTTCCATTTAAATGTTTCCGTAAG
TACTCTCATCATTTGGAAAATACTTGATGGCAGGAGAACTTGCTTAAAACTAAAGGTGGAGAAAGAGTTAACTTCCAGGACAACCCATTA
TAGCTCACTTCTTACCAACAAAGCAGTTTTTATACAGCACCTTAGGACTCATTTCTAATGTCAACCCAGATGGCCAGTAAAGGCAAGGGA
AGAGGCTAAGTGACTCACAAAAATCTCTGATATTGAGGTCTAATGTGAAGGCTATAGATAGGAATTCCCCACAAACTTCTAATGAGGACT
AATATGAACAGCAAATTGGAGAAGACACCAAGGACCTAATTTTAGTTTCACTAGCCGTGGGACCTTAGAAAAAAGACCATTTGCTCTGGA
CTTTTGTTTCCCAAGCCATAAAATGTGGAAGAATCTTCACAATTTCAAGTTGGTCATGTATATTTCCCTTTTACAGAGAAAGCTGAAGCC
TCGAGGCTCAGATTTACCTGGCTTCTGTTTACCTGGCTTCTGCAGAAGTTTAACTTGTAACCTACCTCTCATTCCCAAAGTGTGTTTAAT
CATGCCGCCTTCTTTAAAATATATCTGGAAGCACCAATGAGTAAAGACAAAGGCCCCAAGCTAGATCTGTAGAGATAAGTACTAGACTCA
CATCTCAGTACTATCAAGGAAAACATGCTTAGGTTATCAGAATTGTGAAGGCCATAGTACAAAAAGTTAAGAGAACGGAACTCAGGATCT
GAGAAAGATCAGCCATTCTCAGCATGTTGCCTTGGCTGCTTAACCTTACTAAACTTCCATTTCCTCACATGTAAAATGTACATCATAATA
ACTAGTCTACTGAGATAAGGGAAGAATACTTAGCACAGTGCTAGTACACTGTAAGTACTCAAATGTTACAGATCCAAGTATTTTGTAAGA
AAATACCAGCAAAAGATAAAAGTTTTTTTATGGATCGTATTTGTATCAATCACCTACATGATCTAGAGCCCTCACATGGATAACATTTAA
ATGTTCAGTTTGCCTAATAGCCTTCAATGAAACACGGATTCTTCTACTTAAAAAAGGTAAGCCTGGAGAAAATAAAACTGATTACTATGC
AAGAAAAAAATGTGCTCTGCTGTGCTCCTTGGTATTTTTAAGTGGTTTCCATTGTCTTAACACCTGTCTTAAAACGGGTATGTTGTTTGC
ACTGAACCCTCAAAAGTATTTATACCTATTAAGTTAAATTTCCCTTTTTAGAGTTAATGCTTCATTGCCTGTCGGCATATTATCACTATC
TGTCTTTGAAAAATTTTCTTTTAAGTCTCAACTATTTCTTCATAAAGCTCTTGTTCAGAGAAACATTTTTTGATTTGTCCAATGGACTGA

>52136_52136_2_MCCC1-FXR1_MCCC1_chr3_182788786_ENST00000539926_FXR1_chr3_180679255_ENST00000357559_length(amino acids)=290AA_BP=0
MVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSD
WSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRT
DEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEE

--------------------------------------------------------------
>52136_52136_3_MCCC1-FXR1_MCCC1_chr3_182788787_ENST00000539926_FXR1_chr3_180679256_ENST00000305586_length(transcript)=2345nt_BP=606nt
AGTGGAGGAACGGGTTTGGCGTGTGGGACGCAGCTGCCTCTGTACTGGGGAGTCACGGAGTGGCCGGGCTCCAGGGACATGGCGGCGGCC
TCTGCGGTGTCGGTGCTGCTGGTGGCGGCGGAGAGGAACCGGTGGCATCGTCTCCCGAGCCTGCTCCTGCCGCCGAGGACATGGGTGTGG
AGGCAAAGAACCATGAAGTACACAACAGCCACAGGCTATCCATCCAGGATGCGGTTTTCTCTCAGAAAACATGGAATTTGCTGAACTTTG
TAAGCAAGAAGGAATTATTTTTATAGGCCCTCCTCCATCTGCAATTAGAGACATGGGTATAAAGAGCACATCCAAATCCATAATGGCTGC
TGCTGGAGTACCTGTTGTGGAGGGTTATCATGGTGAGGACCAATCAGACCAGTGCCTGAAGGAACACGCCAGGAGAATTGGCTATCCTGT
CATGATTAAAGCCGTCCGGGGTGGAGGAGGAAAAGGAATGAGGATTGTTAGATCAGAACAAGAATTTCAAGAACAGTTAGAGTCAGCACG
GAGAGAAGCTAAGAAGTCTTTCAATGATGATGCTATGCTGATCGAGAAGTTTGTAGACACACCGAGGGTATGGTTCCATTTGTATTTGTT
GGCACTAAAGAAAGCATTGGAAATGTGCAGGTTCTTCTAGAGTATCATATTGCCTATCTAAAGGAAGTAGAACAGCTAAGAATGGAACGC
CTACAGATTGATGAACAGCTGCGACAGATTGGTTCTAGGTCTTATAGCGGAAGAGGCAGAGGTCGTCGGGGACCTAATTACACCTCCGGT
TATGGTACAAATTCTGAGCTGTCTAACCCCTCTGAAACGGAATCTGAGCGTAAAGACGAGCTGAGTGATTGGTCATTGGCAGGAGAAGAT
GATCGAGACAGCCGACATCAGCGTGACAGCAGGAGACGCCCAGGAGGAAGAGGCAGAAGTGTTTCAGGGGGTCGAGGTCGTGGTGGACCA
CGTGGTGGCAAATCCTCCATCAGTTCTGTGCTCAAAGATCCAGACAGCAATCCATACAGCTTACTTGATAATACAGAATCAGATCAGACT
GCAGACACTGATGCCAGCGAATCTCATCACAGTACTAACCGTCGTAGGCGGTCTCGTAGACGAAGGACTGATGAAGATGCTGTTCTGATG
GATGGAATGACTGAATCTGATACAGCTTCAGTTAATGAAAATGGGCTAGTCACAGTTGCAGATTATATTTCTAGAGCTGAGTCTCAGAGC
AGACAAAGAAACCTCCCAAGGGAAACTTTGGCTAAAAACAAGAAAGAAATGGCAAAAGATGTGATTGAAGAGCATGGTCCTTCAGAAAAG
GCAATAAACGGCCCAACTAGTGCTTCTGGCGATGACATTTCTAAGCTACAGCGTACTCCAGGAGAAGAAAAGATTAATACCTTAAAAGAA
GAAAACACTCAAGAAGCAGCAGTCCTGAATGGTGTTTCATAAACTGAAGAAGTTCCTAGTTTACAGTTCTTTTACATTACATTTACAATA
GTGCTTGTACAAGCTTGCCAAAGATAGAATATGGATCGCCAGTCTTTACATCGCACTTTCAGTTCCTCCATTTGGAATTCAAAAAGGGGA
GGGATCCTGAAGAAATCATATGTTAAACATACTTTGACACCTACTGTGTTATAAAATATATCATCAGATGTGCCTTGAGAATAGTATATG
TAACATTAAAAAAAAGTTGCTGGCTATAGGAAATGTTATTTTGTTTTCAAAATATGGCAGAGATGGGGGGTGGTGGGTGGGGTGGGATCC
CTAACGTAATATTCTTTATGAAAGCATTAGCTGCTTTTGTTACATTTTTAATATGCAACCACTTCTTCACCTGAGGAAAACTAGAATGAA
ATGCAGTCTAAAATATTTTGCACTGAATTGTAATTTCTTCATTAGTTTAGTCTGGAAACTGGTCTGTTTTAATGTGTTTTTTAAATGCTG
TATGTAGAGGAAAATCTGCAGACCACTGGAATACATTTGTTAAACTCTCATCTGCAGGGACACTGGGCGATACTTGGCAGTGACTGTTCT
ACCTTGAGGCTTTGTTTGGTTTATTTATTAAAGTGTACAGTATTTAAAAATCAAACATAGCTTTAGTTAAAACACTAAGCTGAATTAGTC
ATGTCCATTCAGACATAACCTGAACTACTGAAAAGATCAATTTCCAGAAGGTTTATTCTGTATAAACTACATGTTAGTCTTCAGTAGAGT
ATCTTTTTTTTTTCCTTTTTTTTTTTTTTATTTCGGTTGTTTGATGTGCAATATGTTTTTGTATGCAGGTAGTAAATAAACTTTGATCTT

>52136_52136_3_MCCC1-FXR1_MCCC1_chr3_182788787_ENST00000539926_FXR1_chr3_180679256_ENST00000305586_length(amino acids)=290AA_BP=0
MVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSD
WSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRT
DEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEE

--------------------------------------------------------------
>52136_52136_4_MCCC1-FXR1_MCCC1_chr3_182788787_ENST00000539926_FXR1_chr3_180679256_ENST00000357559_length(transcript)=7943nt_BP=606nt
AGTGGAGGAACGGGTTTGGCGTGTGGGACGCAGCTGCCTCTGTACTGGGGAGTCACGGAGTGGCCGGGCTCCAGGGACATGGCGGCGGCC
TCTGCGGTGTCGGTGCTGCTGGTGGCGGCGGAGAGGAACCGGTGGCATCGTCTCCCGAGCCTGCTCCTGCCGCCGAGGACATGGGTGTGG
AGGCAAAGAACCATGAAGTACACAACAGCCACAGGCTATCCATCCAGGATGCGGTTTTCTCTCAGAAAACATGGAATTTGCTGAACTTTG
TAAGCAAGAAGGAATTATTTTTATAGGCCCTCCTCCATCTGCAATTAGAGACATGGGTATAAAGAGCACATCCAAATCCATAATGGCTGC
TGCTGGAGTACCTGTTGTGGAGGGTTATCATGGTGAGGACCAATCAGACCAGTGCCTGAAGGAACACGCCAGGAGAATTGGCTATCCTGT
CATGATTAAAGCCGTCCGGGGTGGAGGAGGAAAAGGAATGAGGATTGTTAGATCAGAACAAGAATTTCAAGAACAGTTAGAGTCAGCACG
GAGAGAAGCTAAGAAGTCTTTCAATGATGATGCTATGCTGATCGAGAAGTTTGTAGACACACCGAGGGTATGGTTCCATTTGTATTTGTT
GGCACTAAAGAAAGCATTGGAAATGTGCAGGTTCTTCTAGAGTATCATATTGCCTATCTAAAGGAAGTAGAACAGCTAAGAATGGAACGC
CTACAGATTGATGAACAGCTGCGACAGATTGGTTCTAGGTCTTATAGCGGAAGAGGCAGAGGTCGTCGGGGACCTAATTACACCTCCGGT
TATGGTACAAATTCTGAGCTGTCTAACCCCTCTGAAACGGAATCTGAGCGTAAAGACGAGCTGAGTGATTGGTCATTGGCAGGAGAAGAT
GATCGAGACAGCCGACATCAGCGTGACAGCAGGAGACGCCCAGGAGGAAGAGGCAGAAGTGTTTCAGGGGGTCGAGGTCGTGGTGGACCA
CGTGGTGGCAAATCCTCCATCAGTTCTGTGCTCAAAGATCCAGACAGCAATCCATACAGCTTACTTGATAATACAGAATCAGATCAGACT
GCAGACACTGATGCCAGCGAATCTCATCACAGTACTAACCGTCGTAGGCGGTCTCGTAGACGAAGGACTGATGAAGATGCTGTTCTGATG
GATGGAATGACTGAATCTGATACAGCTTCAGTTAATGAAAATGGGCTAGTCACAGTTGCAGATTATATTTCTAGAGCTGAGTCTCAGAGC
AGACAAAGAAACCTCCCAAGGGAAACTTTGGCTAAAAACAAGAAAGAAATGGCAAAAGATGTGATTGAAGAGCATGGTCCTTCAGAAAAG
GCAATAAACGGCCCAACTAGTGCTTCTGGCGATGACATTTCTAAGCTACAGCGTACTCCAGGAGAAGAAAAGATTAATACCTTAAAAGAA
GAAAACACTCAAGAAGCAGCAGTCCTGAATGGTGTTTCATAAACTGAAGAAGTTCCTAGTTTACAGTTCTTTTACATTACATTTACAATA
GTGCTTGTACAAGCTTGCCAAAGATAGAATATGGATCGCCAGTCTTTACATCGCACTTTCAGTTCCTCCATTTGGAATTCAAAAAGGGGA
GGGATCCTGAAGAAATCATATGTTAAACATACTTTGACACCTACTGTGTTATAAAATATATCATCAGATGTGCCTTGAGAATAGTATATG
TAACATTAAAAAAAAGTTGCTGGCTATAGGAAATGTTATTTTGTTTTCAAAATATGGCAGAGATGGGGGGTGGTGGGTGGGGTGGGATCC
CTAACGTAATATTCTTTATGAAAGCATTAGCTGCTTTTGTTACATTTTTAATATGCAACCACTTCTTCACCTGAGGAAAACTAGAATGAA
ATGCAGTCTAAAATATTTTGCACTGAATTGTAATTTCTTCATTAGTTTAGTCTGGAAACTGGTCTGTTTTAATGTGTTTTTTAAATGCTG
TATGTAGAGGAAAATCTGCAGACCACTGGAATACATTTGTTAAACTCTCATCTGCAGGGACACTGGGCGATACTTGGCAGTGACTGTTCT
ACCTTGAGGCTTTGTTTGGTTTATTTATTAAAGTGTACAGTATTTAAAAATCAAACATAGCTTTAGTTAAAACACTAAGCTGAATTAGTC
ATGTCCATTCAGACATAACCTGAACTACTGAAAAGATCAATTTCCAGAAGGTTTATTCTGTATAAACTACATGTTAGTCTTCAGTAGAGT
ATCTTTTTTTTTTCCTTTTTTTTTTTTTTATTTCGGTTGTTTGATGTGCAATATGTTTTTGTATGCAGGTAGTAAATAAACTTTGATCTT
CCATTTGCTGAATTTTTTTAACTTTCTACTTTTTACACCAATTGTTGCAAAATAGTTGGAGCTATTAATAGGCTTAGGATAGTATACTTT
GCTTTTTAAAAAGCATTTATACTTGCTCATAAATAGCATTAAAATGTCAGTTGGCCATTTAATCATTTTGTAATGAATCATCTGAAATCT
TTACACAAGTTTAGGCTGTTAGATGCATAGGTAATTAATAATACATGTGATAATTAGCAAAAAAACCTAACAAAATTCTAATCAAAGGCA
ACTTTGGAAGACAATGGGGGATAGAAGGGATGACAAGCAATTTTTAAATAATAGGCCAATGATTTGCTTTATTCATTCTCAACTTATTTT
GAAGGCTCTCATATCAGTGACCAAAAATCAGTTATTAAACTTTATGTATATATTTTAGCCAGAGCTTAATTTTTATGAAGATAAAGACAT
GAAGTTTAACAATGGACAACAGTTAGTACAGCTAATTGTGAGGTCAAGTAATTGTTAGACATAGGGGAAGGCTTTGTTCCACAATATTAT
ATGGACCACTGAACAAGAATGACAGCCCTTTGTTATCACTTGGCATATGAAAAGTGTTGTGTGCATAGTTTGTGTTAATTTTTTATGTGC
ATAAAAATGTGATTTTAATTTATATGCTCTGAAGGATAATTCAGGGTATAGTTAAAAATGTACAATGTGCCAGTTCAGTATATATAACCC
TAGCCCTCAAATTATTCTGATTAAGGTTAAAATGTGCTGGTATTACGTGCTTTTTCCTGAGGCCTTCTGATTGGTTCTTGGTAACAGAAT
TTTAAAGTAAGGTGTGAGTAGTGCAACTCCTGTCCTTTATATATAAAGATATCAAGTAATTTCATGTCCTGATATTTAAAAAAATTACCC
ACAAATGTGTTTTTTTAAATCGATCAAAGCTAGCAACAGGTTAAATTGTCTCAGTTCTCTTACATAATTGGGTTAAAAATTATAAGGTAT
TAGAAGAATTTTAATTAATGCCAAATTGGTAAATATGGTGTAAAAAAAAAAAAAAAGACTTTTCATTTTCTCCCACATAGAATAGTCAGA
TATATTAAACATCCCTTTTCCATAAAGATGGTTTCAATGGGAATGGAAGAAACAAAATCTTAAAAGAGTGAGTATAGCTGAACCAATTCT
TCATTCTAGCAATAACCACACTAAGTTCATTACTTTACAAATGACTAAACCCAATGTCTTGTCCTTTAAAAAATATAGGTAGTGCAGAAT
TGTGATAAATACGCATTTGTTTTTTTAGAGAGCCCCACTCCCCAAAGGGTAGCCATTAATTCAGGTAGCCTTTTAAATGTATTTGAGAGG
GTTCCGTCTTTTTGGCTGCTATCCTAGTTAGGTGAGATGTTGCTATGGGAAGAACTTGCCACTATACACTAAACAGACACTTAAGCAAAA
GATGTATTCTGGAGCCTGGCACAGTAGCTTATGTCTTTGGTTCTAGCTACTCAGGAGCCTGAGGTGGGAGCATCATTTGAACTCAGTTCT
GGGCCACTGAGACCCTCTTTAAAGAGAAGGAAAAAAAGGTATTCTGGAAGATCTTGTGCAGTTGCAACAATGTTTCAGCATATATATGTG
AATTCATATATGACACCTGAACGGAATCATGAAGTAACAGCTGAGATTATATGGTGGCAAAAATGACCTGCTTTTCCTGAAGCTTTGGGA
GGCCTAGGATTCTTGCTTTAGGCATCACCTTTGTTAAGCCTTAAAGGGGGCTACAACTTGTGCAAAATGGTGTCTCTGGTAACACTTCAG
AAATAATTGGCAAAAGTGTAATAGGAATACACAAATCTTTATTTTGAAATAATCTTGTATTTTAATGTGGAATTAGAAGCAGCACATCAA
ACTGGTGAGTTCACAGAAACTTACCTGAGATGATGCTGGGTTCCATTGCTGTTGTGCTAAGTCACGTATTTTTGTAGCTGCTGTTAGCTG
TGTCTAGCGTTTTGTAACCTAAGGAGGGTCTTATAGAAGTTGGTATGTTAACTAAATCTTGGACTGGGAAACAGCACCATTTGTATCCTC
TGCAAACAGATTTACGCTTTTGAGGCTCAAACCAACTAGTGTTCTCATGGGCTGTTGCCTAAGGACAGATAAACATGGAAAACAGGCTAT
GTCCAGGGACAGATGATTGGTGGTTAAGAATTACAGTAAAGGAAAATTACACCTGGATTTTCTTCTGTAAAGTTTCAAGGAACTTGGATT
TGAACTGTGAATCTACTGTTTTGGCAAAAAATCTCAAAGAAAAGGATGTTTGTTACTGTCTCAGTCTTCCTGTCTTTGCTACACGATTTG
GATCCCTTACGCTTTTTCGTTAAGAATATCTGTCTGCTATAGTGAATTTGCTAGCCCCTTATTTTTTTTTTTAATTTTAGTTCTTTATTA
GAACGTGTACTTGAATGGACTGTAGTTGCTCATAACCCATGTTAATCTCTGATAGTATTTGGGTTTTATTTCAGGAGCTTTTGCAATAAA
GCAGTAACTGCAATCTGCTAAAGTCAGACTGTTAGCAAGTGGTGTTAAAACTGATTTAAGTCCATTACACTGAACAGTAGGAAATTACCA
CTTTTGTAAGGCTCAAAAATGATCAACTATTAACAGTTTCTTATGGTTCAGTCTAATTACAAATTTTTAAAAAGTTTATCAGTGTATCAT
TTCAGATTCATCTGTATCTTCTGTAATATTATTTCCAGTACTGAGGTAAGGTACACAAAAATTCCCCTGGAAAAACTATATTCTAGTTTT
GTAAGATGATTTCCCACAGTCCATTTGCTTATTTCTTCCTTTGATAATTCAAAAAGATGCTTTAGGTAATGGTACAGAATTAGAAGCTGC
TATTTTAGCTCTATTAACTTTTTCTCTATGGTTTCAATTTTATCCAACCAGAGAGGGCTGGCCTAGTTGGTATCTTTAAGGCCCTTCCAG
TAGTAATTTGAGTCTAGTCACATGTCAGACCCTGAGCAACACCTAACCAAATGCCCAAGTATTCTCATAAGGAGTATGCTGAATTTAAGT
GGTGTTTGTTTTACATATGTATCCATCCCAGACATTTTCAACTATGCTGAATGCAATCTATAAGATATTCCAAACAAGGACAAAGTAATT
TTTCACAAGTCTTACAGCCCCACTATTAAGTATGCTACTAATTAGCTTCTTGAATTTCTTTGTATTTCAGTGATTGGGATGTTCTTTTTT
TTTGGGAAAGTTTTTTTACCCCTTTGTACCCTCTTAATTGGATTAACTGTAAAATGTACATATTAATTTTCTAGTTTTAGAGACCATTTT
CATTAAAAATATTTTCCAATAGTTTTTCTAGATAAACAATTTATACTTAATTGTTGCTTGGTTGCTTACATTTCAACCTCTAGGCTTCCT
TTTTCAGCTAACTTGGCTGTCTTCAGGTTGTAAAGAAAAATGTAAACATATATTTGAAATTTCATTAACTGAAACTGCTGTAAGGTGTTA
GCAAATGTTAACCATAACAGATTATCCCATATCATTGGACTGTTCTATTATTGGGTCAGGAATAATAGGTGACACAGGATAGAAGCTCTT
CCTATATATATCTTGTTGCTAAGGCAGTAGTTGGCTCTAAGCTGATAAACAGCACACTGTACAGCAGTCCAAAAACTAAAACCAGAGCTT
AGGTCATTCAAGTTAACTGGTACTCAAGGTTACTCATTCCAGGATACTTTACATAACCAAAAACCTAGGAGAGCATTCTACATTGTAATT
TTTTTTTTACTTTGTTTACATAAAATTTACAGGGTTTTGTTTTTTTAAGCTTAGTCTGTTCTTTGACATTGTTGATTCATGTTCTAAATT
TTCATCAGATTTAACATGTTTGGAGGTTCTTGTGCACTCAATGTGAACCTACTACAAGCTTCTGAACTGCAAAACCTTTTTTTTAGGTCA
CTGTCAACAGAAAGATGCCTTATAGAATTTCTCATGATTGAAACAGAACTCTGCATTCTAACCTAAAACCCCTCTAACCCTTTAAATGAA
GCATTATGCCTGCGTGAAATTTTATTTTTAGACATTTCTGATACTAGGTTTTCTTTACGGGGGGGCATACATATTCAGTATACTGAATTT
ATACAGCTTTCAGTGTGGCAATATATTAAGAAGCTAGTTCCCTAATTTTTCTCAGTTCTCATTGGTTTTCCATTTAAATGTTTCCGTAAG
TACTCTCATCATTTGGAAAATACTTGATGGCAGGAGAACTTGCTTAAAACTAAAGGTGGAGAAAGAGTTAACTTCCAGGACAACCCATTA
TAGCTCACTTCTTACCAACAAAGCAGTTTTTATACAGCACCTTAGGACTCATTTCTAATGTCAACCCAGATGGCCAGTAAAGGCAAGGGA
AGAGGCTAAGTGACTCACAAAAATCTCTGATATTGAGGTCTAATGTGAAGGCTATAGATAGGAATTCCCCACAAACTTCTAATGAGGACT
AATATGAACAGCAAATTGGAGAAGACACCAAGGACCTAATTTTAGTTTCACTAGCCGTGGGACCTTAGAAAAAAGACCATTTGCTCTGGA
CTTTTGTTTCCCAAGCCATAAAATGTGGAAGAATCTTCACAATTTCAAGTTGGTCATGTATATTTCCCTTTTACAGAGAAAGCTGAAGCC
TCGAGGCTCAGATTTACCTGGCTTCTGTTTACCTGGCTTCTGCAGAAGTTTAACTTGTAACCTACCTCTCATTCCCAAAGTGTGTTTAAT
CATGCCGCCTTCTTTAAAATATATCTGGAAGCACCAATGAGTAAAGACAAAGGCCCCAAGCTAGATCTGTAGAGATAAGTACTAGACTCA
CATCTCAGTACTATCAAGGAAAACATGCTTAGGTTATCAGAATTGTGAAGGCCATAGTACAAAAAGTTAAGAGAACGGAACTCAGGATCT
GAGAAAGATCAGCCATTCTCAGCATGTTGCCTTGGCTGCTTAACCTTACTAAACTTCCATTTCCTCACATGTAAAATGTACATCATAATA
ACTAGTCTACTGAGATAAGGGAAGAATACTTAGCACAGTGCTAGTACACTGTAAGTACTCAAATGTTACAGATCCAAGTATTTTGTAAGA
AAATACCAGCAAAAGATAAAAGTTTTTTTATGGATCGTATTTGTATCAATCACCTACATGATCTAGAGCCCTCACATGGATAACATTTAA
ATGTTCAGTTTGCCTAATAGCCTTCAATGAAACACGGATTCTTCTACTTAAAAAAGGTAAGCCTGGAGAAAATAAAACTGATTACTATGC
AAGAAAAAAATGTGCTCTGCTGTGCTCCTTGGTATTTTTAAGTGGTTTCCATTGTCTTAACACCTGTCTTAAAACGGGTATGTTGTTTGC
ACTGAACCCTCAAAAGTATTTATACCTATTAAGTTAAATTTCCCTTTTTAGAGTTAATGCTTCATTGCCTGTCGGCATATTATCACTATC
TGTCTTTGAAAAATTTTCTTTTAAGTCTCAACTATTTCTTCATAAAGCTCTTGTTCAGAGAAACATTTTTTGATTTGTCCAATGGACTGA

>52136_52136_4_MCCC1-FXR1_MCCC1_chr3_182788787_ENST00000539926_FXR1_chr3_180679256_ENST00000357559_length(amino acids)=290AA_BP=0
MVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSD
WSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRT
DEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEE

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Fusion Gene PPI Analysis for MCCC1-FXR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MCCC1-FXR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MCCC1-FXR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource