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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MCC-DBN1 (FusionGDB2 ID:52152)

Fusion Gene Summary for MCC-DBN1

check button Fusion gene summary
Fusion gene informationFusion gene name: MCC-DBN1
Fusion gene ID: 52152
HgeneTgene
Gene symbol

MCC

DBN1

Gene ID

4163

1627

Gene nameMCC regulator of WNT signaling pathwaydrebrin 1
SynonymsMCC1D0S117E
Cytomap

5q22.2

5q35.3

Type of geneprotein-codingprotein-coding
Descriptioncolorectal mutant cancer proteinMCC, WNT signaling pathway regulatormutated in colorectal cancersdrebrindevelopmentally-regulated brain proteindrebrin Adrebrin Edrebrin E2
Modification date2020031320200320
UniProtAcc.

Q16643

Ensembl transtripts involved in fusion geneENST00000302475, ENST00000514701, 
ENST00000408903, ENST00000515367, 
ENST00000393563, ENST00000512501, 
ENST00000292385, ENST00000309007, 
ENST00000393565, 
Fusion gene scores* DoF score11 X 8 X 5=44010 X 9 X 7=630
# samples 1210
** MAII scorelog2(12/440*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MCC [Title/Abstract] AND DBN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMCC(112630026)-DBN1(176887704), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMCC

GO:0045184

establishment of protein localization

18591935

HgeneMCC

GO:0050680

negative regulation of epithelial cell proliferation

18591935

HgeneMCC

GO:0090090

negative regulation of canonical Wnt signaling pathway

18591935

TgeneDBN1

GO:0051220

cytoplasmic sequestering of protein

28966017


check buttonFusion gene breakpoints across MCC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DBN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BC-A10T-01AMCCchr5

112630026

-DBN1chr5

176887556

-
ChimerDB4LIHCTCGA-BC-A10T-01AMCCchr5

112630026

-DBN1chr5

176887704

-


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Fusion Gene ORF analysis for MCC-DBN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000302475ENST00000393563MCCchr5

112630026

-DBN1chr5

176887704

-
5CDS-5UTRENST00000302475ENST00000512501MCCchr5

112630026

-DBN1chr5

176887704

-
5UTR-3CDSENST00000514701ENST00000292385MCCchr5

112630026

-DBN1chr5

176887556

-
5UTR-3CDSENST00000514701ENST00000292385MCCchr5

112630026

-DBN1chr5

176887704

-
5UTR-3CDSENST00000514701ENST00000309007MCCchr5

112630026

-DBN1chr5

176887556

-
5UTR-3CDSENST00000514701ENST00000309007MCCchr5

112630026

-DBN1chr5

176887704

-
5UTR-3CDSENST00000514701ENST00000393563MCCchr5

112630026

-DBN1chr5

176887556

-
5UTR-3CDSENST00000514701ENST00000393565MCCchr5

112630026

-DBN1chr5

176887556

-
5UTR-3CDSENST00000514701ENST00000393565MCCchr5

112630026

-DBN1chr5

176887704

-
5UTR-3CDSENST00000514701ENST00000512501MCCchr5

112630026

-DBN1chr5

176887556

-
5UTR-5UTRENST00000514701ENST00000393563MCCchr5

112630026

-DBN1chr5

176887704

-
5UTR-5UTRENST00000514701ENST00000512501MCCchr5

112630026

-DBN1chr5

176887704

-
In-frameENST00000302475ENST00000292385MCCchr5

112630026

-DBN1chr5

176887556

-
In-frameENST00000302475ENST00000292385MCCchr5

112630026

-DBN1chr5

176887704

-
In-frameENST00000302475ENST00000309007MCCchr5

112630026

-DBN1chr5

176887556

-
In-frameENST00000302475ENST00000309007MCCchr5

112630026

-DBN1chr5

176887704

-
In-frameENST00000302475ENST00000393563MCCchr5

112630026

-DBN1chr5

176887556

-
In-frameENST00000302475ENST00000393565MCCchr5

112630026

-DBN1chr5

176887556

-
In-frameENST00000302475ENST00000393565MCCchr5

112630026

-DBN1chr5

176887704

-
In-frameENST00000302475ENST00000512501MCCchr5

112630026

-DBN1chr5

176887556

-
intron-3CDSENST00000408903ENST00000292385MCCchr5

112630026

-DBN1chr5

176887556

-
intron-3CDSENST00000408903ENST00000292385MCCchr5

112630026

-DBN1chr5

176887704

-
intron-3CDSENST00000408903ENST00000309007MCCchr5

112630026

-DBN1chr5

176887556

-
intron-3CDSENST00000408903ENST00000309007MCCchr5

112630026

-DBN1chr5

176887704

-
intron-3CDSENST00000408903ENST00000393563MCCchr5

112630026

-DBN1chr5

176887556

-
intron-3CDSENST00000408903ENST00000393565MCCchr5

112630026

-DBN1chr5

176887556

-
intron-3CDSENST00000408903ENST00000393565MCCchr5

112630026

-DBN1chr5

176887704

-
intron-3CDSENST00000408903ENST00000512501MCCchr5

112630026

-DBN1chr5

176887556

-
intron-3CDSENST00000515367ENST00000292385MCCchr5

112630026

-DBN1chr5

176887556

-
intron-3CDSENST00000515367ENST00000292385MCCchr5

112630026

-DBN1chr5

176887704

-
intron-3CDSENST00000515367ENST00000309007MCCchr5

112630026

-DBN1chr5

176887556

-
intron-3CDSENST00000515367ENST00000309007MCCchr5

112630026

-DBN1chr5

176887704

-
intron-3CDSENST00000515367ENST00000393563MCCchr5

112630026

-DBN1chr5

176887556

-
intron-3CDSENST00000515367ENST00000393565MCCchr5

112630026

-DBN1chr5

176887556

-
intron-3CDSENST00000515367ENST00000393565MCCchr5

112630026

-DBN1chr5

176887704

-
intron-3CDSENST00000515367ENST00000512501MCCchr5

112630026

-DBN1chr5

176887556

-
intron-5UTRENST00000408903ENST00000393563MCCchr5

112630026

-DBN1chr5

176887704

-
intron-5UTRENST00000408903ENST00000512501MCCchr5

112630026

-DBN1chr5

176887704

-
intron-5UTRENST00000515367ENST00000393563MCCchr5

112630026

-DBN1chr5

176887704

-
intron-5UTRENST00000515367ENST00000512501MCCchr5

112630026

-DBN1chr5

176887704

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000302475MCCchr5112630026-ENST00000309007DBN1chr5176887704-26256215641799411
ENST00000302475MCCchr5112630026-ENST00000292385DBN1chr5176887704-23066215641799411
ENST00000302475MCCchr5112630026-ENST00000393565DBN1chr5176887704-24356215641937457
ENST00000302475MCCchr5112630026-ENST00000309007DBN1chr5176887556-25656215641739391
ENST00000302475MCCchr5112630026-ENST00000292385DBN1chr5176887556-22466215641739391
ENST00000302475MCCchr5112630026-ENST00000393565DBN1chr5176887556-23756215641877437
ENST00000302475MCCchr5112630026-ENST00000393563DBN1chr5176887556-18066215641739391
ENST00000302475MCCchr5112630026-ENST00000512501DBN1chr5176887556-22576215641769401

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000302475ENST00000309007MCCchr5112630026-DBN1chr5176887704-0.008764420.9912356
ENST00000302475ENST00000292385MCCchr5112630026-DBN1chr5176887704-0.0105337520.98946625
ENST00000302475ENST00000393565MCCchr5112630026-DBN1chr5176887704-0.0124287360.98757124
ENST00000302475ENST00000309007MCCchr5112630026-DBN1chr5176887556-0.0114458560.9885542
ENST00000302475ENST00000292385MCCchr5112630026-DBN1chr5176887556-0.0138886390.9861114
ENST00000302475ENST00000393565MCCchr5112630026-DBN1chr5176887556-0.0257919780.974208
ENST00000302475ENST00000393563MCCchr5112630026-DBN1chr5176887556-0.0144803110.98551977
ENST00000302475ENST00000512501MCCchr5112630026-DBN1chr5176887556-0.0461844430.9538155

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Fusion Genomic Features for MCC-DBN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MCC-DBN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:112630026/chr5:176887704)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DBN1

Q16643

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCCchr5:112630026chr5:176887556ENST00000302475-117766_78219830.0MotifNuclear localization signal
HgeneMCCchr5:112630026chr5:176887556ENST00000302475-117826_82919830.0MotifNote=PDZ-binding
HgeneMCCchr5:112630026chr5:176887556ENST00000408903-119766_78201020.0MotifNuclear localization signal
HgeneMCCchr5:112630026chr5:176887556ENST00000408903-119826_82901020.0MotifNote=PDZ-binding
HgeneMCCchr5:112630026chr5:176887704ENST00000302475-117766_78219830.0MotifNuclear localization signal
HgeneMCCchr5:112630026chr5:176887704ENST00000302475-117826_82919830.0MotifNote=PDZ-binding
HgeneMCCchr5:112630026chr5:176887704ENST00000408903-119766_78201020.0MotifNuclear localization signal
HgeneMCCchr5:112630026chr5:176887704ENST00000408903-119826_82901020.0MotifNote=PDZ-binding
TgeneDBN1chr5:112630026chr5:176887556ENST000002923859153_134279652.0DomainADF-H
TgeneDBN1chr5:112630026chr5:176887556ENST000003090078143_134277650.0DomainADF-H
TgeneDBN1chr5:112630026chr5:176887556ENST000003935658153_134277696.0DomainADF-H
TgeneDBN1chr5:112630026chr5:176887704ENST000002923858153_134259652.0DomainADF-H
TgeneDBN1chr5:112630026chr5:176887704ENST000003090077143_134257650.0DomainADF-H
TgeneDBN1chr5:112630026chr5:176887704ENST000003935657153_134257696.0DomainADF-H


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Fusion Gene Sequence for MCC-DBN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52152_52152_1_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887556_ENST00000292385_length(transcript)=2246nt_BP=621nt
AGAAACCACTTACAACTCCAGACGATTCGAAGGGGAAACTTCGGCGTGAAGTGCAGCTCCGCTCCGGCTCCCTCTAGCTTTCTTTCCTTC
TCTGGAATCCGAGGCGCGGATCTTCCTCGCCCCACCGCCCTAGTTTTTTCGGGAGCTCGCCGGTGCCCTCTAGGGTGTCGGCTCGTGCTG
GGAAGTGCCCTCCATCCTGGTAATGGGGGGCGGCGAGGCACCGTAGGAGTGGCGAGGCGGCGCCCAGGGTGGCACTGCCCCGGAACGGGG
CGCTGGGTGCGCGCGGGAGGGTCCCCGCGCGGGCTCCGCCGCTGCCGCAGCTGCGAGCGCGCCGCGCCACCGAGCCTCCTGCAGCAATGG
CTCGTCCGTGAAACGCGAGCCACGGCTGCTCTTTTTAAGAGTGCCTGCATCCTCCGTTTGCGCTTCGCAACTGTCCTGGGTGAAAATGGC
TGTCTAGACTAAAATGTGGCAGAAGGGACCAAGCAGTGGATATTGAGCCTGTGAAGTCCAACTCTTAAGCTCCGAGACCTGGGGGACTGA
GAGCCCAGCTCTGAAAAGTGCATCATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGAGGCAGCA
GCTATTATTGCCCAGCGGCCTGACAACCCAAGGGAGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTA
CCCTCGCCCTTCAACCATCGACCAGGCAGCCACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGAC
TCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCA
CCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCC
ATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCT
GTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCT
GACACCACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAG
GGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTG
CTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAA
GGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTA
ACCAATGGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAA
GAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGAA
GAGGAGGAGGGCTTCGAGGGTGGTGATTAGCGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCTCTGGCC
AGACGGCCCGCCGTGCCTGCATTCGCAGCAGCTCCGCCTGGCACCCACTCCGGATTCCGGCCCTGGCTGGGGACTTGGCCGCTTCCCTAC
CCACAGGGCCTGACTTTTACAGCTTTTCTCTTTTTTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGCTTTCCTCTCGTTGGTAGT
TGAGACGCTGTTGCAAATTCCACCCCTCCTTCCCTGGTCCAGATTGTAGCTCTTAGTCCTCCCTGCTCAGCTGGCCGGGTTGGAGGCCTC
ACCCTGCTTGGGGCCTGGCGTGGGGGGAGCTCTGGTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTATGTTTCTTGGGAAAATATCA

>52152_52152_1_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887556_ENST00000292385_length(amino acids)=391AA_BP=19
MNSGVAMKYGNDSSAELSEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPV
AEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEP
ATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCA
TLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPP

--------------------------------------------------------------
>52152_52152_2_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887556_ENST00000309007_length(transcript)=2565nt_BP=621nt
AGAAACCACTTACAACTCCAGACGATTCGAAGGGGAAACTTCGGCGTGAAGTGCAGCTCCGCTCCGGCTCCCTCTAGCTTTCTTTCCTTC
TCTGGAATCCGAGGCGCGGATCTTCCTCGCCCCACCGCCCTAGTTTTTTCGGGAGCTCGCCGGTGCCCTCTAGGGTGTCGGCTCGTGCTG
GGAAGTGCCCTCCATCCTGGTAATGGGGGGCGGCGAGGCACCGTAGGAGTGGCGAGGCGGCGCCCAGGGTGGCACTGCCCCGGAACGGGG
CGCTGGGTGCGCGCGGGAGGGTCCCCGCGCGGGCTCCGCCGCTGCCGCAGCTGCGAGCGCGCCGCGCCACCGAGCCTCCTGCAGCAATGG
CTCGTCCGTGAAACGCGAGCCACGGCTGCTCTTTTTAAGAGTGCCTGCATCCTCCGTTTGCGCTTCGCAACTGTCCTGGGTGAAAATGGC
TGTCTAGACTAAAATGTGGCAGAAGGGACCAAGCAGTGGATATTGAGCCTGTGAAGTCCAACTCTTAAGCTCCGAGACCTGGGGGACTGA
GAGCCCAGCTCTGAAAAGTGCATCATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGAGGCAGCA
GCTATTATTGCCCAGCGGCCTGACAACCCAAGGGAGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTA
CCCTCGCCCTTCAACCATCGACCAGGCAGCCACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGAC
TCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCA
CCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCC
ATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCT
GTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCT
GACACCACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAG
GGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTG
CTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAA
GGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTA
ACCAATGGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAA
GAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGAA
GAGGAGGAGGGCTTCGAGGGTGGTGATTAGCGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCTCTGGCC
AGACGGCCCGCCGTGCCTGCATTCGCAGCAGCTCCGCCTGGCACCCACTCCGGATTCCGGCCCTGGCTGGGGACTTGGCCGCTTCCCTAC
CCACAGGGCCTGACTTTTACAGCTTTTCTCTTTTTTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGCTTTCCTCTCGTTGGTAGT
TGAGACGCTGTTGCAAATTCCACCCCTCCTTCCCTGGTCCAGATTGTAGCTCTTAGTCCTCCCTGCTCAGCTGGCCGGGTTGGAGGCCTC
ACCCTGCTTGGGGCCTGGCGTGGGGGGAGCTCTGGTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTATGTTTCTTGGGAAAATATCA
CTTTGTATTCTCTGTCCAGGGCTTCAGATATTTTGCACGAATTTTAAAACATGGCAATAAATGGCTCGTGGGCTCTGGCTCCCTGGGACC
CCCTCCCCGCCCTTCTTTTGACCCCTTCCTGTCTGGCCCAAAGGAAGTAGCAGGCCCAGCTGGGGCCCCTCGGCTACCCCCCGTCTCCTG
CCGGGCAGGTCCCAGGTTGGAGGCCCTAGGCGCGGTTCAGGTCAGGGCTATGGATGGGGCCCAGGGGCTTTGGTGGCCCCTCCCCAACTC
CTTCCTCTTTGCTTGGGTTCCTTTTTCACGTTTAGTAACTGTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGAAAGCACAAACTTCTGTAA

>52152_52152_2_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887556_ENST00000309007_length(amino acids)=391AA_BP=19
MNSGVAMKYGNDSSAELSEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPV
AEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEP
ATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCA
TLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPP

--------------------------------------------------------------
>52152_52152_3_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887556_ENST00000393563_length(transcript)=1806nt_BP=621nt
AGAAACCACTTACAACTCCAGACGATTCGAAGGGGAAACTTCGGCGTGAAGTGCAGCTCCGCTCCGGCTCCCTCTAGCTTTCTTTCCTTC
TCTGGAATCCGAGGCGCGGATCTTCCTCGCCCCACCGCCCTAGTTTTTTCGGGAGCTCGCCGGTGCCCTCTAGGGTGTCGGCTCGTGCTG
GGAAGTGCCCTCCATCCTGGTAATGGGGGGCGGCGAGGCACCGTAGGAGTGGCGAGGCGGCGCCCAGGGTGGCACTGCCCCGGAACGGGG
CGCTGGGTGCGCGCGGGAGGGTCCCCGCGCGGGCTCCGCCGCTGCCGCAGCTGCGAGCGCGCCGCGCCACCGAGCCTCCTGCAGCAATGG
CTCGTCCGTGAAACGCGAGCCACGGCTGCTCTTTTTAAGAGTGCCTGCATCCTCCGTTTGCGCTTCGCAACTGTCCTGGGTGAAAATGGC
TGTCTAGACTAAAATGTGGCAGAAGGGACCAAGCAGTGGATATTGAGCCTGTGAAGTCCAACTCTTAAGCTCCGAGACCTGGGGGACTGA
GAGCCCAGCTCTGAAAAGTGCATCATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGAGGCAGCA
GCTATTATTGCCCAGCGGCCTGACAACCCAAGGGAGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTA
CCCTCGCCCTTCAACCATCGACCAGGCAGCCACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGAC
TCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCA
CCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCC
ATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCT
GTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCT
GACACCACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAG
GGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTG
CTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAA
GGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTA
ACCAATGGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAA
GAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGAA
GAGGAGGAGGGCTTCGAGGGTGGTGATTAGCGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCTCTGGCC

>52152_52152_3_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887556_ENST00000393563_length(amino acids)=391AA_BP=19
MNSGVAMKYGNDSSAELSEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPV
AEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEP
ATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCA
TLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPP

--------------------------------------------------------------
>52152_52152_4_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887556_ENST00000393565_length(transcript)=2375nt_BP=621nt
AGAAACCACTTACAACTCCAGACGATTCGAAGGGGAAACTTCGGCGTGAAGTGCAGCTCCGCTCCGGCTCCCTCTAGCTTTCTTTCCTTC
TCTGGAATCCGAGGCGCGGATCTTCCTCGCCCCACCGCCCTAGTTTTTTCGGGAGCTCGCCGGTGCCCTCTAGGGTGTCGGCTCGTGCTG
GGAAGTGCCCTCCATCCTGGTAATGGGGGGCGGCGAGGCACCGTAGGAGTGGCGAGGCGGCGCCCAGGGTGGCACTGCCCCGGAACGGGG
CGCTGGGTGCGCGCGGGAGGGTCCCCGCGCGGGCTCCGCCGCTGCCGCAGCTGCGAGCGCGCCGCGCCACCGAGCCTCCTGCAGCAATGG
CTCGTCCGTGAAACGCGAGCCACGGCTGCTCTTTTTAAGAGTGCCTGCATCCTCCGTTTGCGCTTCGCAACTGTCCTGGGTGAAAATGGC
TGTCTAGACTAAAATGTGGCAGAAGGGACCAAGCAGTGGATATTGAGCCTGTGAAGTCCAACTCTTAAGCTCCGAGACCTGGGGGACTGA
GAGCCCAGCTCTGAAAAGTGCATCATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGAGGCAGCA
GCTATTATTGCCCAGCGGCCTGACAACCCAAGGGAGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTA
CCCTCGCCCTTCAACCATCGACCAGGTCGTCCGTACTGCCCTTTCATAAAGGCATCGGACAGTGGGCCTTCCTCCTCCTCCTCTTCCTCC
TCCTCCCCTCCACGGACTCCCTTTCCCTATATCACCTGCCACCGCACCCCAAACCTCTCTTCCTCCCTCCCATGCAGCCACCTGGACAGC
CACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGG
GCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTA
GACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCA
GGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACG
GAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGC
CTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTC
ACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGAT
GAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCA
GCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGT
GAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAG
CCTCCAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGAAGAGGAGGAGGGCTTCGAGGGTGGTGATTAGCGGTGGCGCCAG
CCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCTCTGGCCAGACGGCCCGCCGTGCCTGCATTCGCAGCAGCTCCGCCTGGC
ACCCACTCCGGATTCCGGCCCTGGCTGGGGACTTGGCCGCTTCCCTACCCACAGGGCCTGACTTTTACAGCTTTTCTCTTTTTTTAAAAA
GTTGATAGGAGACTTGTACAGTTGACTGGCTTTCCTCTCGTTGGTAGTTGAGACGCTGTTGCAAATTCCACCCCTCCTTCCCTGGTCCAG
ATTGTAGCTCTTAGTCCTCCCTGCTCAGCTGGCCGGGTTGGAGGCCTCACCCTGCTTGGGGCCTGGCGTGGGGGGAGCTCTGGTGGGAAA
ATGTCCCCCACCTCTTTTCCTAGTTTTATGTTTCTTGGGAAAATATCACTTTGTATTCTCTGTCCAGGGCTTCAGATATTTTGCACGAAT

>52152_52152_4_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887556_ENST00000393565_length(amino acids)=437AA_BP=19
MNSGVAMKYGNDSSAELSEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGRPYCPFIKASDSGPSSSSSSSSSPPRTPF
PYITCHRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAA
APQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGN
GEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQE

--------------------------------------------------------------
>52152_52152_5_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887556_ENST00000512501_length(transcript)=2257nt_BP=621nt
AGAAACCACTTACAACTCCAGACGATTCGAAGGGGAAACTTCGGCGTGAAGTGCAGCTCCGCTCCGGCTCCCTCTAGCTTTCTTTCCTTC
TCTGGAATCCGAGGCGCGGATCTTCCTCGCCCCACCGCCCTAGTTTTTTCGGGAGCTCGCCGGTGCCCTCTAGGGTGTCGGCTCGTGCTG
GGAAGTGCCCTCCATCCTGGTAATGGGGGGCGGCGAGGCACCGTAGGAGTGGCGAGGCGGCGCCCAGGGTGGCACTGCCCCGGAACGGGG
CGCTGGGTGCGCGCGGGAGGGTCCCCGCGCGGGCTCCGCCGCTGCCGCAGCTGCGAGCGCGCCGCGCCACCGAGCCTCCTGCAGCAATGG
CTCGTCCGTGAAACGCGAGCCACGGCTGCTCTTTTTAAGAGTGCCTGCATCCTCCGTTTGCGCTTCGCAACTGTCCTGGGTGAAAATGGC
TGTCTAGACTAAAATGTGGCAGAAGGGACCAAGCAGTGGATATTGAGCCTGTGAAGTCCAACTCTTAAGCTCCGAGACCTGGGGGACTGA
GAGCCCAGCTCTGAAAAGTGCATCATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGAGGCAGCA
GCTATTATTGCCCAGCGGCCTGACAACCCAAGGGAGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTA
CCCTCGCCCTTCAACCATCGACCAGGCAGCCACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGAC
TCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCA
CCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCC
ATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCT
GTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCT
GACACCACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAG
GGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTG
CTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAA
GGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTA
ACCAATGGCGAGACCACCCAGAAGGAGGGGACCCAGGTGCGGCAGGGACTGCCTGGTGGGAGGGATGGGAGGGAGTGGGGGCTGAGCAGG
GTGCTGGCCCTGCATTCCTCATGCTTGCACCAGTACCCCCTTCTCTGTGACCCACATTATTTGAGGGGAAGTCCATCCCACCCTCCCTCC
CTGGGCCGGCTCTGCTTTTGTTCCCAAGGCAGGCATCCTTGTTTCCCTGGCAACCACTGATGGAATCATTGGTTGCTGGGGAAACGGGCT
CAGGCCTGATAGGTCAGCCCCAGTCCTGCTGGGTGGGGCCAAGTGACCTGATGCTTTCCCCTGCAGGCCAGTGAGGGGTACTTCAGTCAA
TCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGGTAGTACTGGG
CTGGATGATGGGGAGGAATTTGGGTGCGGGGGCTGGATTTGAGTGTGGGTAGCCACCCCACCACTACCCACCGCTCACAGAGGCTGGGGA
CACAAGCGGTCTGCTAGGTCCCTAACTCCTCTCCCTTTCTAACGCCACAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGA
AGAGGAGGAGGGCTTCGAGGGTGGTGATTAGCGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCTCTGGC

>52152_52152_5_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887556_ENST00000512501_length(amino acids)=401AA_BP=19
MNSGVAMKYGNDSSAELSEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPV
AEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEP
ATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCA
TLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQVRQGLPGGRDGREWGLSRVLALHSSC

--------------------------------------------------------------
>52152_52152_6_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887704_ENST00000292385_length(transcript)=2306nt_BP=621nt
AGAAACCACTTACAACTCCAGACGATTCGAAGGGGAAACTTCGGCGTGAAGTGCAGCTCCGCTCCGGCTCCCTCTAGCTTTCTTTCCTTC
TCTGGAATCCGAGGCGCGGATCTTCCTCGCCCCACCGCCCTAGTTTTTTCGGGAGCTCGCCGGTGCCCTCTAGGGTGTCGGCTCGTGCTG
GGAAGTGCCCTCCATCCTGGTAATGGGGGGCGGCGAGGCACCGTAGGAGTGGCGAGGCGGCGCCCAGGGTGGCACTGCCCCGGAACGGGG
CGCTGGGTGCGCGCGGGAGGGTCCCCGCGCGGGCTCCGCCGCTGCCGCAGCTGCGAGCGCGCCGCGCCACCGAGCCTCCTGCAGCAATGG
CTCGTCCGTGAAACGCGAGCCACGGCTGCTCTTTTTAAGAGTGCCTGCATCCTCCGTTTGCGCTTCGCAACTGTCCTGGGTGAAAATGGC
TGTCTAGACTAAAATGTGGCAGAAGGGACCAAGCAGTGGATATTGAGCCTGTGAAGTCCAACTCTTAAGCTCCGAGACCTGGGGGACTGA
GAGCCCAGCTCTGAAAAGTGCATCATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGGTGACCAT
CGGGATGAGGAGGAAGAGACCCACATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCA
AGGGAGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGCAGC
CACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAG
CAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCC
AGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCT
CCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACA
GCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCC
GCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCG
GGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTT
CTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCA
ACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGG
ACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTG
TTCTACAACAAGCCTCCAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGAAGAGGAGGAGGGCTTCGAGGGTGGTGATTAG
CGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCTCTGGCCAGACGGCCCGCCGTGCCTGCATTCGCAGCA
GCTCCGCCTGGCACCCACTCCGGATTCCGGCCCTGGCTGGGGACTTGGCCGCTTCCCTACCCACAGGGCCTGACTTTTACAGCTTTTCTC
TTTTTTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGCTTTCCTCTCGTTGGTAGTTGAGACGCTGTTGCAAATTCCACCCCTCCT
TCCCTGGTCCAGATTGTAGCTCTTAGTCCTCCCTGCTCAGCTGGCCGGGTTGGAGGCCTCACCCTGCTTGGGGCCTGGCGTGGGGGGAGC
TCTGGTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTATGTTTCTTGGGAAAATATCACTTTGTATTCTCTGTCCAGGGCTTCAGATA

>52152_52152_6_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887704_ENST00000292385_length(amino acids)=411AA_BP=19
MNSGVAMKYGNDSSAELSEGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRM
APTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPA
EDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAE
VPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYF

--------------------------------------------------------------
>52152_52152_7_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887704_ENST00000309007_length(transcript)=2625nt_BP=621nt
AGAAACCACTTACAACTCCAGACGATTCGAAGGGGAAACTTCGGCGTGAAGTGCAGCTCCGCTCCGGCTCCCTCTAGCTTTCTTTCCTTC
TCTGGAATCCGAGGCGCGGATCTTCCTCGCCCCACCGCCCTAGTTTTTTCGGGAGCTCGCCGGTGCCCTCTAGGGTGTCGGCTCGTGCTG
GGAAGTGCCCTCCATCCTGGTAATGGGGGGCGGCGAGGCACCGTAGGAGTGGCGAGGCGGCGCCCAGGGTGGCACTGCCCCGGAACGGGG
CGCTGGGTGCGCGCGGGAGGGTCCCCGCGCGGGCTCCGCCGCTGCCGCAGCTGCGAGCGCGCCGCGCCACCGAGCCTCCTGCAGCAATGG
CTCGTCCGTGAAACGCGAGCCACGGCTGCTCTTTTTAAGAGTGCCTGCATCCTCCGTTTGCGCTTCGCAACTGTCCTGGGTGAAAATGGC
TGTCTAGACTAAAATGTGGCAGAAGGGACCAAGCAGTGGATATTGAGCCTGTGAAGTCCAACTCTTAAGCTCCGAGACCTGGGGGACTGA
GAGCCCAGCTCTGAAAAGTGCATCATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGGTGACCAT
CGGGATGAGGAGGAAGAGACCCACATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCA
AGGGAGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGCAGC
CACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAG
CAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCC
AGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCT
CCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACA
GCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCC
GCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCG
GGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTT
CTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCA
ACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGG
ACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTG
TTCTACAACAAGCCTCCAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGAAGAGGAGGAGGGCTTCGAGGGTGGTGATTAG
CGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCTCTGGCCAGACGGCCCGCCGTGCCTGCATTCGCAGCA
GCTCCGCCTGGCACCCACTCCGGATTCCGGCCCTGGCTGGGGACTTGGCCGCTTCCCTACCCACAGGGCCTGACTTTTACAGCTTTTCTC
TTTTTTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGCTTTCCTCTCGTTGGTAGTTGAGACGCTGTTGCAAATTCCACCCCTCCT
TCCCTGGTCCAGATTGTAGCTCTTAGTCCTCCCTGCTCAGCTGGCCGGGTTGGAGGCCTCACCCTGCTTGGGGCCTGGCGTGGGGGGAGC
TCTGGTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTATGTTTCTTGGGAAAATATCACTTTGTATTCTCTGTCCAGGGCTTCAGATA
TTTTGCACGAATTTTAAAACATGGCAATAAATGGCTCGTGGGCTCTGGCTCCCTGGGACCCCCTCCCCGCCCTTCTTTTGACCCCTTCCT
GTCTGGCCCAAAGGAAGTAGCAGGCCCAGCTGGGGCCCCTCGGCTACCCCCCGTCTCCTGCCGGGCAGGTCCCAGGTTGGAGGCCCTAGG
CGCGGTTCAGGTCAGGGCTATGGATGGGGCCCAGGGGCTTTGGTGGCCCCTCCCCAACTCCTTCCTCTTTGCTTGGGTTCCTTTTTCACG
TTTAGTAACTGTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGAAAGCACAAACTTCTGTAACGGGTCGTGCTCATGTCTGTTAATAAAGAA

>52152_52152_7_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887704_ENST00000309007_length(amino acids)=411AA_BP=19
MNSGVAMKYGNDSSAELSEGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRM
APTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPA
EDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAE
VPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYF

--------------------------------------------------------------
>52152_52152_8_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887704_ENST00000393565_length(transcript)=2435nt_BP=621nt
AGAAACCACTTACAACTCCAGACGATTCGAAGGGGAAACTTCGGCGTGAAGTGCAGCTCCGCTCCGGCTCCCTCTAGCTTTCTTTCCTTC
TCTGGAATCCGAGGCGCGGATCTTCCTCGCCCCACCGCCCTAGTTTTTTCGGGAGCTCGCCGGTGCCCTCTAGGGTGTCGGCTCGTGCTG
GGAAGTGCCCTCCATCCTGGTAATGGGGGGCGGCGAGGCACCGTAGGAGTGGCGAGGCGGCGCCCAGGGTGGCACTGCCCCGGAACGGGG
CGCTGGGTGCGCGCGGGAGGGTCCCCGCGCGGGCTCCGCCGCTGCCGCAGCTGCGAGCGCGCCGCGCCACCGAGCCTCCTGCAGCAATGG
CTCGTCCGTGAAACGCGAGCCACGGCTGCTCTTTTTAAGAGTGCCTGCATCCTCCGTTTGCGCTTCGCAACTGTCCTGGGTGAAAATGGC
TGTCTAGACTAAAATGTGGCAGAAGGGACCAAGCAGTGGATATTGAGCCTGTGAAGTCCAACTCTTAAGCTCCGAGACCTGGGGGACTGA
GAGCCCAGCTCTGAAAAGTGCATCATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGGTGACCAT
CGGGATGAGGAGGAAGAGACCCACATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCA
AGGGAGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGTCGT
CCGTACTGCCCTTTCATAAAGGCATCGGACAGTGGGCCTTCCTCCTCCTCCTCTTCCTCCTCCTCCCCTCCACGGACTCCCTTTCCCTAT
ATCACCTGCCACCGCACCCCAAACCTCTCTTCCTCCCTCCCATGCAGCCACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCC
ACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCT
CCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCT
CAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATG
GAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAA
ACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAA
GGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAG
GTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGT
GACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAG
CCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAG
GAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATCGACATCACATGCTGGGAT
GCAGACCCAGTTCCAGAAGAGGAGGAGGGCTTCGAGGGTGGTGATTAGCGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCAC
CTGCATCAGCCTCTGGCCAGACGGCCCGCCGTGCCTGCATTCGCAGCAGCTCCGCCTGGCACCCACTCCGGATTCCGGCCCTGGCTGGGG
ACTTGGCCGCTTCCCTACCCACAGGGCCTGACTTTTACAGCTTTTCTCTTTTTTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGC
TTTCCTCTCGTTGGTAGTTGAGACGCTGTTGCAAATTCCACCCCTCCTTCCCTGGTCCAGATTGTAGCTCTTAGTCCTCCCTGCTCAGCT
GGCCGGGTTGGAGGCCTCACCCTGCTTGGGGCCTGGCGTGGGGGGAGCTCTGGTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTATG
TTTCTTGGGAAAATATCACTTTGTATTCTCTGTCCAGGGCTTCAGATATTTTGCACGAATTTTAAAACATGGCAATAAATGGCTCGTGGG

>52152_52152_8_MCC-DBN1_MCC_chr5_112630026_ENST00000302475_DBN1_chr5_176887704_ENST00000393565_length(amino acids)=457AA_BP=19
MNSGVAMKYGNDSSAELSEGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGRPYCPFIKA
SDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPP
PAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADT
TVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGE
SLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEE

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Fusion Gene PPI Analysis for MCC-DBN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MCC-DBN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MCC-DBN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource