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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MCF2L2-DMRT1 (FusionGDB2 ID:52171)

Fusion Gene Summary for MCF2L2-DMRT1

check button Fusion gene summary
Fusion gene informationFusion gene name: MCF2L2-DMRT1
Fusion gene ID: 52171
HgeneTgene
Gene symbol

MCF2L2

DMRT1

Gene ID

23101

1761

Gene nameMCF.2 cell line derived transforming sequence-like 2doublesex and mab-3 related transcription factor 1
SynonymsARHGEF22CT154|DMT1
Cytomap

3q27.1

9p24.3

Type of geneprotein-codingprotein-coding
Descriptionprobable guanine nucleotide exchange factor MCF2L2MCF2-transforming sequence-like protein 2dbs-related Rho family guanine nucleotide exchange factordoublesex- and mab-3-related transcription factor 1DM domain expressed in testis 1DM domain expressed in testis protein 1
Modification date2020031320200313
UniProtAcc

Q86YR7

.
Ensembl transtripts involved in fusion geneENST00000328913, ENST00000414362, 
ENST00000447025, ENST00000473233, 
ENST00000468976, 		ENST00000382276, 
ENST00000569227, 
Fusion gene scores* DoF score5 X 6 X 3=903 X 5 X 3=45
# samples 45
** MAII scorelog2(4/90*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MCF2L2 [Title/Abstract] AND DMRT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMCF2L2(182994660)-DMRT1(967985), # samples:1
Anticipated loss of major functional domain due to fusion event.MCF2L2-DMRT1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MCF2L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DMRT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A29H-06AMCF2L2chr3

182994660

-DMRT1chr9

967985

+


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Fusion Gene ORF analysis for MCF2L2-DMRT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000328913ENST00000382276MCF2L2chr3

182994660

-DMRT1chr9

967985

+
Frame-shiftENST00000414362ENST00000382276MCF2L2chr3

182994660

-DMRT1chr9

967985

+
Frame-shiftENST00000447025ENST00000382276MCF2L2chr3

182994660

-DMRT1chr9

967985

+
Frame-shiftENST00000473233ENST00000382276MCF2L2chr3

182994660

-DMRT1chr9

967985

+
In-frameENST00000328913ENST00000569227MCF2L2chr3

182994660

-DMRT1chr9

967985

+
In-frameENST00000414362ENST00000569227MCF2L2chr3

182994660

-DMRT1chr9

967985

+
In-frameENST00000447025ENST00000569227MCF2L2chr3

182994660

-DMRT1chr9

967985

+
In-frameENST00000473233ENST00000569227MCF2L2chr3

182994660

-DMRT1chr9

967985

+
intron-3CDSENST00000468976ENST00000382276MCF2L2chr3

182994660

-DMRT1chr9

967985

+
intron-3CDSENST00000468976ENST00000569227MCF2L2chr3

182994660

-DMRT1chr9

967985

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000328913MCF2L2chr3182994660-ENST00000569227DMRT1chr9967985+26912160702223717
ENST00000473233MCF2L2chr3182994660-ENST00000569227DMRT1chr9967985+2393186201925641
ENST00000447025MCF2L2chr3182994660-ENST00000569227DMRT1chr9967985+25011970182033671
ENST00000414362MCF2L2chr3182994660-ENST00000569227DMRT1chr9967985+25171986342049671

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328913ENST00000569227MCF2L2chr3182994660-DMRT1chr9967985+0.0066107790.99338925
ENST00000473233ENST00000569227MCF2L2chr3182994660-DMRT1chr9967985+0.0063636130.99363637
ENST00000447025ENST00000569227MCF2L2chr3182994660-DMRT1chr9967985+0.0063838880.9936161
ENST00000414362ENST00000569227MCF2L2chr3182994660-DMRT1chr9967985+0.0064785390.9935215

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Fusion Genomic Features for MCF2L2-DMRT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MCF2L2-DMRT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:182994660/chr9:967985)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MCF2L2

Q86YR7

.
FUNCTION: Probably functions as a guanine nucleotide exchange factor. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCF2L2chr3:182994660chr9:967985ENST00000328913-153011_1936201115.0DomainCRAL-TRIO
HgeneMCF2L2chr3:182994660chr9:967985ENST00000414362-151611_193620629.0DomainCRAL-TRIO
HgeneMCF2L2chr3:182994660chr9:967985ENST00000447025-151811_193620712.0DomainCRAL-TRIO
HgeneMCF2L2chr3:182994660chr9:967985ENST00000473233-152911_1936201075.0DomainCRAL-TRIO
HgeneMCF2L2chr3:182994660chr9:967985ENST00000328913-1530323_4286201115.0RepeatNote=Spectrin
HgeneMCF2L2chr3:182994660chr9:967985ENST00000414362-1516323_428620629.0RepeatNote=Spectrin
HgeneMCF2L2chr3:182994660chr9:967985ENST00000447025-1518323_428620712.0RepeatNote=Spectrin
HgeneMCF2L2chr3:182994660chr9:967985ENST00000473233-1529323_4286201075.0RepeatNote=Spectrin
TgeneDMRT1chr3:182994660chr9:967985ENST0000038227635322_347322374.0Compositional biasNote=Pro/Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCF2L2chr3:182994660chr9:967985ENST00000328913-1530619_8226201115.0DomainDH
HgeneMCF2L2chr3:182994660chr9:967985ENST00000328913-1530834_9546201115.0DomainPH
HgeneMCF2L2chr3:182994660chr9:967985ENST00000414362-1516619_822620629.0DomainDH
HgeneMCF2L2chr3:182994660chr9:967985ENST00000414362-1516834_954620629.0DomainPH
HgeneMCF2L2chr3:182994660chr9:967985ENST00000447025-1518619_822620712.0DomainDH
HgeneMCF2L2chr3:182994660chr9:967985ENST00000447025-1518834_954620712.0DomainPH
HgeneMCF2L2chr3:182994660chr9:967985ENST00000473233-1529619_8226201075.0DomainDH
HgeneMCF2L2chr3:182994660chr9:967985ENST00000473233-1529834_9546201075.0DomainPH
TgeneDMRT1chr3:182994660chr9:967985ENST000003822763572_118322374.0DNA bindingDM


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Fusion Gene Sequence for MCF2L2-DMRT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52171_52171_1_MCF2L2-DMRT1_MCF2L2_chr3_182994660_ENST00000328913_DMRT1_chr9_967985_ENST00000569227_length(transcript)=2691nt_BP=2160nt
CGGGGCGCGGTTCCGGCGAGATTGGCGACTTGCTTCCTTTTGCAGAACGGCCGCTCCTCTCTCGGTCCAGCTGCGACGCTGGGAAAGCGC
CAGACTTGGTCTGTCACGGGAGCCCCCGCGGGGCGTGGCGAGGGAGAGCTGGCCTAGGCTGCGAGGGACTCTCGTTTCTTGCCTGGAGAG
CCAGGAAGAGGGCGAGGGCAGAGCATCCTTGGGCGGAGATGCCTTTAAAAAATCATCCACCGCAGCGGTAGAAACAGTTTTGTTTGGCTT
TATTTATACGGAATGGTTTTTCAGTGAAATGCTGTCTTGCTTAAAAGAAGAGATGCCTCCCCAGGAGCTCACCCGGCGACTGGCCACAGT
GATCACTCATGTCGATGAAATTATGCAGCAGGAAGTCAGACCCCTGATGGCGGTGGAGATAATAGAACAACTTCACAGACAATTTGCCAT
TCTTTCAGGAGGCCGAGGGGAGGATGGCGCCCCCATCATCACGTTCCCAGAGTTTTCGGGGTTCAAACACATCCCAGATGAAGACTTCCT
GAATGTCATGACCTACCTGACTAGCATCCCCAGTGTGGAGGCTGCCAGCATTGGATTCATTGTTGTTATCGACAGACGAAGAGACAAGTG
GAGCTCCGTAAAGGCATCCTTGACACGAATAGCTGTGGCATTTCCAGGAAACTTACAGCTCATATTCATCCTTCGTCCATCTCGCTTTAT
CCAGAGGACATTCACTGACATTGGCATTAAATACTATCGAAATGAGTTTAAAACGAAAGTGCCGATCATCATGGTAAACTCTGTCTCTGA
CCTTCACGGCTACATCGACAAAAGCCAACTGACCCGGGAATTAGGGGGGACTTTGGAATATCGCCACGGTCAGTGGGTAAATCACCGCAC
TGCCATCGAAAACTTTGCCTTGACCTTGAAGACCACTGCCCAGATGCTGCAGACGTTTGGGTCCTGCCTGGCCACAGCAGAGCTGCCCAG
AAGCATGCTATCCACGGAAGACCTTCTCATGTCCCACACAAGGCAGCGGGACAAGCTGCAGGATGAGCTGAAATTACTTGGAAAGCAGGG
GACCACATTGCTGTCATGCATCCAAGAACCAGCAACCAAATGTCCCAACAGCAAACTCAATCTCAACCAACTTGAGAATGTAACTACCAT
GGAAAGGTTATTAGTTCAACTGGATGAAACAGAAAAAGCCTTTAGTCACTTTTGGTCTGAGCATCATCTGAAGCTTAACCAGTGCCTACA
ACTACAGCATTTTGAGCACGATTTTTGTAAGGCTAAGCTTGCCCTGGATAATTTGCTGGAAGAGCAAGCAGAGTTTACAGGCATTGGAGA
CAGCGTGATGCACGTGGAGCAGATTCTTAAGGAACACAAAAAACTGGAGGAAAAAAGCCAGGAGCCCCTGGAAAAGGCCCAGCTGCTGGC
ACTGGTTGGGGACCAGCTCATCCAAAGCCACCATTATGCAGCAGATGCCATCAGGCCCCGGTGTGTGGAGCTCAGGCACCTCTGTGACGA
TTTCATCAATGGAAACAAGAAAAAATGGGACATTTTAGGAAAGTCCTTAGAGTTTCATAGACAGCTGGACAAGGTCAGCCAATGGTGTGA
GGCAGGAATCTACCTCTTGGCTTCCCAAGCTGTAGACAAGTGCCAGTCTCGAGAAGGGGTTGATATCGCCTTGAACGACATTGCGACATT
CCTGGGCACAGTCAAGGAGTACCCGTTGCTCAGCCCCAAGGAGTTTTACAACGAGTTTGAGTTGCTGCTCACCCTCGATGCAAAGGCCAA
AGCCCAGAAAGTTTTGCAGAGGCTGGATGATGTCCAGGAAATATTTCACAAGAGGCAAGTGAGTCTGATGAAACTGGCAGCCAAACAGAC
TCGTCCAGTGCAACCTGTGGCCCCACATCCTGAGTCTTCACCAAAATGGGTGTCATCAAAAACCAGCCAGCCCTCCACCTCGGTCCCTCT
AGCTCGTCCTCTGAGAACGTCTGAGGAACCTTATACGGAGACAGAGTTGAACTCCCGGGGAAAGGAAGATGATGAGACTAAATTTGAAGT
CAAGAGTGAAGAAATCTTTGAAAGCCATCATGAAAGGGGGAACCCTGAGCTGGAGCAGCAGGCCAGGCTCGGAGACCTTTCCCCCCGCAG
TATTCTCGCCGCCCAGCAGTCAAGATTCTGGCTTGGTTTCCCTCTCGAGCAGCTCTCCTATTAGTAACAAGAGCACAAAGGCAGTGCTTG
AATGTGAGCCTGCGTCGGAGCCCAGCAGCTTCACAGTCACTCCCGTCATCGAGGAGGACGAGTGAGCAGTGCCTGCTGCCGATGGCGGTT
CACTTGGAGTAACAGGCTTATTCCACTTTCCATGGGGTTTGTTAATATTTTGCATTGACTCATACTATCTTAACTGTTGAGAACGTATTT
GGTTTATATTCCTTAGAGTTTAGTCCAGAGGCTGTAACACATTTGTAATACTTTAGGGTCCGTGACTACCATCTGCATGGTTTAAGTGCT
TTACTCACGGAGTTTAAATAATAGTGTTCATTTTTTTAATGACACTGGTTTCATGTAGTTTTCAAGAAATAAAAGAATTCATTCAAGTGA

>52171_52171_1_MCF2L2-DMRT1_MCF2L2_chr3_182994660_ENST00000328913_DMRT1_chr9_967985_ENST00000569227_length(amino acids)=717AA_BP=693
MRRWESARLGLSREPPRGVARESWPRLRGTLVSCLESQEEGEGRASLGGDAFKKSSTAAVETVLFGFIYTEWFFSEMLSCLKEEMPPQEL
TRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVI
DRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHG
QWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQ
LENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPL
EKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIA
LNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQ

--------------------------------------------------------------
>52171_52171_2_MCF2L2-DMRT1_MCF2L2_chr3_182994660_ENST00000414362_DMRT1_chr9_967985_ENST00000569227_length(transcript)=2517nt_BP=1986nt
GGAGAGCCAGGAAGAGGGCGAGGGCAGAGCATCCTTGGGCGGAGATGCCTTTAAAAAATCATCCACCGCAGCGGTAGAAACAGTTTTGTT
TGGCTTTATTTATACGGAATGGTTTTTCAGTGAAATGCTGTCTTGCTTAAAAGAAGAGATGCCTCCCCAGGAGCTCACCCGGCGACTGGC
CACAGTGATCACTCATGTCGATGAAATTATGCAGCAGGAAGTCAGACCCCTGATGGCGGTGGAGATAATAGAACAACTTCACAGACAATT
TGCCATTCTTTCAGGAGGCCGAGGGGAGGATGGCGCCCCCATCATCACGTTCCCAGAGTTTTCGGGGTTCAAACACATCCCAGATGAAGA
CTTCCTGAATGTCATGACCTACCTGACTAGCATCCCCAGTGTGGAGGCTGCCAGCATTGGATTCATTGTTGTTATCGACAGACGAAGAGA
CAAGTGGAGCTCCGTAAAGGCATCCTTGACACGAATAGCTGTGGCATTTCCAGGAAACTTACAGCTCATATTCATCCTTCGTCCATCTCG
CTTTATCCAGAGGACATTCACTGACATTGGCATTAAATACTATCGAAATGAGTTTAAAACGAAAGTGCCGATCATCATGGTAAACTCTGT
CTCTGACCTTCACGGCTACATCGACAAAAGCCAACTGACCCGGGAATTAGGGGGGACTTTGGAATATCGCCACGGTCAGTGGGTAAATCA
CCGCACTGCCATCGAAAACTTTGCCTTGACCTTGAAGACCACTGCCCAGATGCTGCAGACGTTTGGGTCCTGCCTGGCCACAGCAGAGCT
GCCCAGAAGCATGCTATCCACGGAAGACCTTCTCATGTCCCACACAAGGCAGCGGGACAAGCTGCAGGATGAGCTGAAATTACTTGGAAA
GCAGGGGACCACATTGCTGTCATGCATCCAAGAACCAGCAACCAAATGTCCCAACAGCAAACTCAATCTCAACCAACTTGAGAATGTAAC
TACCATGGAAAGGTTATTAGTTCAACTGGATGAAACAGAAAAAGCCTTTAGTCACTTTTGGTCTGAGCATCATCTGAAGCTTAACCAGTG
CCTACAACTACAGCATTTTGAGCACGATTTTTGTAAGGCTAAGCTTGCCCTGGATAATTTGCTGGAAGAGCAAGCAGAGTTTACAGGCAT
TGGAGACAGCGTGATGCACGTGGAGCAGATTCTTAAGGAACACAAAAAACTGGAGGAAAAAAGCCAGGAGCCCCTGGAAAAGGCCCAGCT
GCTGGCACTGGTTGGGGACCAGCTCATCCAAAGCCACCATTATGCAGCAGATGCCATCAGGCCCCGGTGTGTGGAGCTCAGGCACCTCTG
TGACGATTTCATCAATGGAAACAAGAAAAAATGGGACATTTTAGGAAAGTCCTTAGAGTTTCATAGACAGCTGGACAAGGTCAGCCAATG
GTGTGAGGCAGGAATCTACCTCTTGGCTTCCCAAGCTGTAGACAAGTGCCAGTCTCGAGAAGGGGTTGATATCGCCTTGAACGACATTGC
GACATTCCTGGGCACAGTCAAGGAGTACCCGTTGCTCAGCCCCAAGGAGTTTTACAACGAGTTTGAGTTGCTGCTCACCCTCGATGCAAA
GGCCAAAGCCCAGAAAGTTTTGCAGAGGCTGGATGATGTCCAGGAAATATTTCACAAGAGGCAAGTGAGTCTGATGAAACTGGCAGCCAA
ACAGACTCGTCCAGTGCAACCTGTGGCCCCACATCCTGAGTCTTCACCAAAATGGGTGTCATCAAAAACCAGCCAGCCCTCCACCTCGGT
CCCTCTAGCTCGTCCTCTGAGAACGTCTGAGGAACCTTATACGGAGACAGAGTTGAACTCCCGGGGAAAGGAAGATGATGAGACTAAATT
TGAAGTCAAGAGTGAAGAAATCTTTGAAAGCCATCATGAAAGGGGGAACCCTGAGCTGGAGCAGCAGGCCAGGCTCGGAGACCTTTCCCC
CCGCAGTATTCTCGCCGCCCAGCAGTCAAGATTCTGGCTTGGTTTCCCTCTCGAGCAGCTCTCCTATTAGTAACAAGAGCACAAAGGCAG
TGCTTGAATGTGAGCCTGCGTCGGAGCCCAGCAGCTTCACAGTCACTCCCGTCATCGAGGAGGACGAGTGAGCAGTGCCTGCTGCCGATG
GCGGTTCACTTGGAGTAACAGGCTTATTCCACTTTCCATGGGGTTTGTTAATATTTTGCATTGACTCATACTATCTTAACTGTTGAGAAC
GTATTTGGTTTATATTCCTTAGAGTTTAGTCCAGAGGCTGTAACACATTTGTAATACTTTAGGGTCCGTGACTACCATCTGCATGGTTTA
AGTGCTTTACTCACGGAGTTTAAATAATAGTGTTCATTTTTTTAATGACACTGGTTTCATGTAGTTTTCAAGAAATAAAAGAATTCATTC

>52171_52171_2_MCF2L2-DMRT1_MCF2L2_chr3_182994660_ENST00000414362_DMRT1_chr9_967985_ENST00000569227_length(amino acids)=671AA_BP=647
MGGDAFKKSSTAAVETVLFGFIYTEWFFSEMLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDG
APIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGI
KYYRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLL
MSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFC
KAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKW
DILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLD
DVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESH

--------------------------------------------------------------
>52171_52171_3_MCF2L2-DMRT1_MCF2L2_chr3_182994660_ENST00000447025_DMRT1_chr9_967985_ENST00000569227_length(transcript)=2501nt_BP=1970nt
GGCGAGGGCAGAGCATCCTTGGGCGGAGATGCCTTTAAAAAATCATCCACCGCAGCGGTAGAAACAGTTTTGTTTGGCTTTATTTATACG
GAATGGTTTTTCAGTGAAATGCTGTCTTGCTTAAAAGAAGAGATGCCTCCCCAGGAGCTCACCCGGCGACTGGCCACAGTGATCACTCAT
GTCGATGAAATTATGCAGCAGGAAGTCAGACCCCTGATGGCGGTGGAGATAATAGAACAACTTCACAGACAATTTGCCATTCTTTCAGGA
GGCCGAGGGGAGGATGGCGCCCCCATCATCACGTTCCCAGAGTTTTCGGGGTTCAAACACATCCCAGATGAAGACTTCCTGAATGTCATG
ACCTACCTGACTAGCATCCCCAGTGTGGAGGCTGCCAGCATTGGATTCATTGTTGTTATCGACAGACGAAGAGACAAGTGGAGCTCCGTA
AAGGCATCCTTGACACGAATAGCTGTGGCATTTCCAGGAAACTTACAGCTCATATTCATCCTTCGTCCATCTCGCTTTATCCAGAGGACA
TTCACTGACATTGGCATTAAATACTATCGAAATGAGTTTAAAACGAAAGTGCCGATCATCATGGTAAACTCTGTCTCTGACCTTCACGGC
TACATCGACAAAAGCCAACTGACCCGGGAATTAGGGGGGACTTTGGAATATCGCCACGGTCAGTGGGTAAATCACCGCACTGCCATCGAA
AACTTTGCCTTGACCTTGAAGACCACTGCCCAGATGCTGCAGACGTTTGGGTCCTGCCTGGCCACAGCAGAGCTGCCCAGAAGCATGCTA
TCCACGGAAGACCTTCTCATGTCCCACACAAGGCAGCGGGACAAGCTGCAGGATGAGCTGAAATTACTTGGAAAGCAGGGGACCACATTG
CTGTCATGCATCCAAGAACCAGCAACCAAATGTCCCAACAGCAAACTCAATCTCAACCAACTTGAGAATGTAACTACCATGGAAAGGTTA
TTAGTTCAACTGGATGAAACAGAAAAAGCCTTTAGTCACTTTTGGTCTGAGCATCATCTGAAGCTTAACCAGTGCCTACAACTACAGCAT
TTTGAGCACGATTTTTGTAAGGCTAAGCTTGCCCTGGATAATTTGCTGGAAGAGCAAGCAGAGTTTACAGGCATTGGAGACAGCGTGATG
CACGTGGAGCAGATTCTTAAGGAACACAAAAAACTGGAGGAAAAAAGCCAGGAGCCCCTGGAAAAGGCCCAGCTGCTGGCACTGGTTGGG
GACCAGCTCATCCAAAGCCACCATTATGCAGCAGATGCCATCAGGCCCCGGTGTGTGGAGCTCAGGCACCTCTGTGACGATTTCATCAAT
GGAAACAAGAAAAAATGGGACATTTTAGGAAAGTCCTTAGAGTTTCATAGACAGCTGGACAAGGTCAGCCAATGGTGTGAGGCAGGAATC
TACCTCTTGGCTTCCCAAGCTGTAGACAAGTGCCAGTCTCGAGAAGGGGTTGATATCGCCTTGAACGACATTGCGACATTCCTGGGCACA
GTCAAGGAGTACCCGTTGCTCAGCCCCAAGGAGTTTTACAACGAGTTTGAGTTGCTGCTCACCCTCGATGCAAAGGCCAAAGCCCAGAAA
GTTTTGCAGAGGCTGGATGATGTCCAGGAAATATTTCACAAGAGGCAAGTGAGTCTGATGAAACTGGCAGCCAAACAGACTCGTCCAGTG
CAACCTGTGGCCCCACATCCTGAGTCTTCACCAAAATGGGTGTCATCAAAAACCAGCCAGCCCTCCACCTCGGTCCCTCTAGCTCGTCCT
CTGAGAACGTCTGAGGAACCTTATACGGAGACAGAGTTGAACTCCCGGGGAAAGGAAGATGATGAGACTAAATTTGAAGTCAAGAGTGAA
GAAATCTTTGAAAGCCATCATGAAAGGGGGAACCCTGAGCTGGAGCAGCAGGCCAGGCTCGGAGACCTTTCCCCCCGCAGTATTCTCGCC
GCCCAGCAGTCAAGATTCTGGCTTGGTTTCCCTCTCGAGCAGCTCTCCTATTAGTAACAAGAGCACAAAGGCAGTGCTTGAATGTGAGCC
TGCGTCGGAGCCCAGCAGCTTCACAGTCACTCCCGTCATCGAGGAGGACGAGTGAGCAGTGCCTGCTGCCGATGGCGGTTCACTTGGAGT
AACAGGCTTATTCCACTTTCCATGGGGTTTGTTAATATTTTGCATTGACTCATACTATCTTAACTGTTGAGAACGTATTTGGTTTATATT
CCTTAGAGTTTAGTCCAGAGGCTGTAACACATTTGTAATACTTTAGGGTCCGTGACTACCATCTGCATGGTTTAAGTGCTTTACTCACGG
AGTTTAAATAATAGTGTTCATTTTTTTAATGACACTGGTTTCATGTAGTTTTCAAGAAATAAAAGAATTCATTCAAGTGAAGCCATTTGT

>52171_52171_3_MCF2L2-DMRT1_MCF2L2_chr3_182994660_ENST00000447025_DMRT1_chr9_967985_ENST00000569227_length(amino acids)=671AA_BP=647
MGGDAFKKSSTAAVETVLFGFIYTEWFFSEMLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDG
APIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGI
KYYRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLL
MSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFC
KAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKW
DILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLD
DVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESH

--------------------------------------------------------------
>52171_52171_4_MCF2L2-DMRT1_MCF2L2_chr3_182994660_ENST00000473233_DMRT1_chr9_967985_ENST00000569227_length(transcript)=2393nt_BP=1862nt
ATGCTGTCTTGCTTAAAAGAAGAGATGCCTCCCCAGGAGCTCACCCGGCGACTGGCCACAGTGATCACTCATGTCGATGAAATTATGCAG
CAGGAAGTCAGACCCCTGATGGCGGTGGAGATAATAGAACAACTTCACAGACAATTTGCCATTCTTTCAGGAGGCCGAGGGGAGGATGGC
GCCCCCATCATCACGTTCCCAGAGTTTTCGGGGTTCAAACACATCCCAGATGAAGACTTCCTGAATGTCATGACCTACCTGACTAGCATC
CCCAGTGTGGAGGCTGCCAGCATTGGATTCATTGTTGTTATCGACAGACGAAGAGACAAGTGGAGCTCCGTAAAGGCATCCTTGACACGA
ATAGCTGTGGCATTTCCAGGAAACTTACAGCTCATATTCATCCTTCGTCCATCTCGCTTTATCCAGAGGACATTCACTGACATTGGCATT
AAATACTATCGAAATGAGTTTAAAACGAAAGTGCCGATCATCATGGTAAACTCTGTCTCTGACCTTCACGGCTACATCGACAAAAGCCAA
CTGACCCGGGAATTAGGGGGGACTTTGGAATATCGCCACGGTCAGTGGGTAAATCACCGCACTGCCATCGAAAACTTTGCCTTGACCTTG
AAGACCACTGCCCAGATGCTGCAGACGTTTGGGTCCTGCCTGGCCACAGCAGAGCTGCCCAGAAGCATGCTATCCACGGAAGACCTTCTC
ATGTCCCACACAAGGCAGCGGGACAAGCTGCAGGATGAGCTGAAATTACTTGGAAAGCAGGGGACCACATTGCTGTCATGCATCCAAGAA
CCAGCAACCAAATGTCCCAACAGCAAACTCAATCTCAACCAACTTGAGAATGTAACTACCATGGAAAGGTTATTAGTTCAACTGGATGAA
ACAGAAAAAGCCTTTAGTCACTTTTGGTCTGAGCATCATCTGAAGCTTAACCAGTGCCTACAACTACAGCATTTTGAGCACGATTTTTGT
AAGGCTAAGCTTGCCCTGGATAATTTGCTGGAAGAGCAAGCAGAGTTTACAGGCATTGGAGACAGCGTGATGCACGTGGAGCAGATTCTT
AAGGAACACAAAAAACTGGAGGAAAAAAGCCAGGAGCCCCTGGAAAAGGCCCAGCTGCTGGCACTGGTTGGGGACCAGCTCATCCAAAGC
CACCATTATGCAGCAGATGCCATCAGGCCCCGGTGTGTGGAGCTCAGGCACCTCTGTGACGATTTCATCAATGGAAACAAGAAAAAATGG
GACATTTTAGGAAAGTCCTTAGAGTTTCATAGACAGCTGGACAAGGTCAGCCAATGGTGTGAGGCAGGAATCTACCTCTTGGCTTCCCAA
GCTGTAGACAAGTGCCAGTCTCGAGAAGGGGTTGATATCGCCTTGAACGACATTGCGACATTCCTGGGCACAGTCAAGGAGTACCCGTTG
CTCAGCCCCAAGGAGTTTTACAACGAGTTTGAGTTGCTGCTCACCCTCGATGCAAAGGCCAAAGCCCAGAAAGTTTTGCAGAGGCTGGAT
GATGTCCAGGAAATATTTCACAAGAGGCAAGTGAGTCTGATGAAACTGGCAGCCAAACAGACTCGTCCAGTGCAACCTGTGGCCCCACAT
CCTGAGTCTTCACCAAAATGGGTGTCATCAAAAACCAGCCAGCCCTCCACCTCGGTCCCTCTAGCTCGTCCTCTGAGAACGTCTGAGGAA
CCTTATACGGAGACAGAGTTGAACTCCCGGGGAAAGGAAGATGATGAGACTAAATTTGAAGTCAAGAGTGAAGAAATCTTTGAAAGCCAT
CATGAAAGGGGGAACCCTGAGCTGGAGCAGCAGGCCAGGCTCGGAGACCTTTCCCCCCGCAGTATTCTCGCCGCCCAGCAGTCAAGATTC
TGGCTTGGTTTCCCTCTCGAGCAGCTCTCCTATTAGTAACAAGAGCACAAAGGCAGTGCTTGAATGTGAGCCTGCGTCGGAGCCCAGCAG
CTTCACAGTCACTCCCGTCATCGAGGAGGACGAGTGAGCAGTGCCTGCTGCCGATGGCGGTTCACTTGGAGTAACAGGCTTATTCCACTT
TCCATGGGGTTTGTTAATATTTTGCATTGACTCATACTATCTTAACTGTTGAGAACGTATTTGGTTTATATTCCTTAGAGTTTAGTCCAG
AGGCTGTAACACATTTGTAATACTTTAGGGTCCGTGACTACCATCTGCATGGTTTAAGTGCTTTACTCACGGAGTTTAAATAATAGTGTT
CATTTTTTTAATGACACTGGTTTCATGTAGTTTTCAAGAAATAAAAGAATTCATTCAAGTGAAGCCATTTGTGTGCCTCTAAATGAGTCA

>52171_52171_4_MCF2L2-DMRT1_MCF2L2_chr3_182994660_ENST00000473233_DMRT1_chr9_967985_ENST00000569227_length(amino acids)=641AA_BP=617
MLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSI
PSVEAASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQ
LTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQE
PATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQIL
KEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQ
AVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPH
PESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHHERGNPELEQQARLGDLSPRSILAAQQSRF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MCF2L2-DMRT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MCF2L2-DMRT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MCF2L2-DMRT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource