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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MCF2L-F10 (FusionGDB2 ID:52176)

Fusion Gene Summary for MCF2L-F10

check button Fusion gene summary
Fusion gene informationFusion gene name: MCF2L-F10
Fusion gene ID: 52176
HgeneTgene
Gene symbol

MCF2L

F10

Gene ID

23263

83541

Gene nameMCF.2 cell line derived transforming sequence likefamily with sequence similarity 110 member A
SynonymsARHGEF14|DBS|OSTC20orf55|F10|bA371L19.3
Cytomap

13q34

20p13

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide exchange factor DBSDBL's big sisterMCF2 transforming sequence-like proteinprotein FAM110A
Modification date2020031320200313
UniProtAcc

O15068

P00742

Ensembl transtripts involved in fusion geneENST00000375597, ENST00000375601, 
ENST00000375604, ENST00000375608, 
ENST00000397030, ENST00000421756, 
ENST00000423482, ENST00000434480, 
ENST00000442652, ENST00000535094, 
ENST00000397021, ENST00000397024, 
ENST00000397036, ENST00000480321, 
ENST00000483537, ENST00000375551, 
ENST00000375559, ENST00000409306, 
Fusion gene scores* DoF score11 X 7 X 8=6166 X 7 X 4=168
# samples 107
** MAII scorelog2(10/616*10)=-2.62293035092018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MCF2L [Title/Abstract] AND F10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMCF2L(113720484)-F10(113803230), # samples:1
MCF2L(113720484)-F10(113803229), # samples:1
Anticipated loss of major functional domain due to fusion event.MCF2L-F10 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MCF2L-F10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
MCF2L-F10 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MCF2L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across F10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-A4ZK-01AMCF2Lchr13

113720484

+F10chr13

113803230

+
ChimerDB4LUSCTCGA-56-A4ZKMCF2Lchr13

113720484

+F10chr13

113803229

+


Top

Fusion Gene ORF analysis for MCF2L-F10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000375597ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000375597ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
5CDS-intronENST00000375601ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000375601ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
5CDS-intronENST00000375604ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000375604ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
5CDS-intronENST00000375608ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000375608ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
5CDS-intronENST00000397030ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000397030ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
5CDS-intronENST00000421756ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000421756ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
5CDS-intronENST00000423482ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000423482ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
5CDS-intronENST00000434480ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000434480ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
5CDS-intronENST00000442652ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000442652ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
5CDS-intronENST00000535094ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000535094ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000375597ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375597ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000375597ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375597ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000375601ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375601ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000375601ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375601ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000375604ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375604ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000375604ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375604ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000375608ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375608ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000375608ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375608ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000397030ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000397030ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000397030ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000397030ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000421756ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000421756ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000421756ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000421756ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000423482ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000423482ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000423482ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000423482ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000434480ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000434480ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000434480ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000434480ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000442652ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000442652ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000442652ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000442652ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000535094ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000535094ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
Frame-shiftENST00000535094ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000535094ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
In-frameENST00000375597ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000375597ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
In-frameENST00000375601ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000375601ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
In-frameENST00000375604ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000375604ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
In-frameENST00000375608ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000375608ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
In-frameENST00000397030ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000397030ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
In-frameENST00000421756ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000421756ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
In-frameENST00000423482ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000423482ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
In-frameENST00000434480ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000434480ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
In-frameENST00000442652ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000442652ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
In-frameENST00000535094ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000535094ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-3CDSENST00000397021ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397021ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-3CDSENST00000397021ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397021ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-3CDSENST00000397021ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397021ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-3CDSENST00000397024ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397024ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-3CDSENST00000397024ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397024ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-3CDSENST00000397024ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397024ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-3CDSENST00000397036ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397036ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-3CDSENST00000397036ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397036ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-3CDSENST00000397036ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397036ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-3CDSENST00000480321ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000480321ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-3CDSENST00000480321ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000480321ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-3CDSENST00000480321ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000480321ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-intronENST00000397021ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-intronENST00000397021ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-intronENST00000397024ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-intronENST00000397024ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-intronENST00000397036ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-intronENST00000397036ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+
intron-intronENST00000480321ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-intronENST00000480321ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803229

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MCF2L-F10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for MCF2L-F10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:113720484/chr13:113803230)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MCF2L

O15068

F10

P00742

FUNCTION: Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). {ECO:0000250|UniProtKB:Q63406, ECO:0000269|PubMed:15157669}.; FUNCTION: [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669). {ECO:0000269|PubMed:15157669}.FUNCTION: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000375597+82752_224291985.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000375608+93052_2243231138.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000397030+82852_2243261097.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000421756+82852_2242971068.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000423482+83052_2242911124.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000434480+82952_2242991114.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000442652+82952_2243231138.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000535094+83052_2242931126.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375597+82752_224291985.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375608+93052_2243231138.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000397030+82852_2243261097.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000421756+82852_2242971068.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000423482+83052_2242911124.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000434480+82952_2242991114.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000442652+82952_2243231138.0DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000535094+83052_2242931126.0DomainCRAL-TRIO
TgeneF10chr13:113720484chr13:113803229ENST0000037555968476_485288489.0RegionNote=O-glycosylated at one site
TgeneF10chr13:113720484chr13:113803230ENST0000037555968476_485288489.0RegionNote=O-glycosylated at one site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000375597+827503_529291985.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000375608+930503_5293231138.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000397030+828503_5293261097.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000421756+828503_5292971068.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000423482+830503_5292911124.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000434480+829503_5292991114.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000442652+829503_5293231138.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000535094+830503_5292931126.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375597+827503_529291985.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375608+930503_5293231138.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000397030+828503_5293261097.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000421756+828503_5292971068.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000423482+830503_5292911124.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000434480+829503_5292991114.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000442652+829503_5293231138.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000535094+830503_5292931126.0Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000375597+8271055_1116291985.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000375597+827631_811291985.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000375597+827829_945291985.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000375608+9301055_11163231138.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000375608+930631_8113231138.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000375608+930829_9453231138.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000397030+8281055_11163261097.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000397030+828631_8113261097.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000397030+828829_9453261097.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000421756+8281055_11162971068.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000421756+828631_8112971068.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000421756+828829_9452971068.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000423482+8301055_11162911124.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000423482+830631_8112911124.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000423482+830829_9452911124.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000434480+8291055_11162991114.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000434480+829631_8112991114.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000434480+829829_9452991114.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000442652+8291055_11163231138.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000442652+829631_8113231138.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000442652+829829_9453231138.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000535094+8301055_11162931126.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000535094+830631_8112931126.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000535094+830829_9452931126.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375597+8271055_1116291985.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375597+827631_811291985.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375597+827829_945291985.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375608+9301055_11163231138.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375608+930631_8113231138.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375608+930829_9453231138.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000397030+8281055_11163261097.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000397030+828631_8113261097.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000397030+828829_9453261097.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000421756+8281055_11162971068.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000421756+828631_8112971068.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000421756+828829_9452971068.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000423482+8301055_11162911124.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000423482+830631_8112911124.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000423482+830829_9452911124.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000434480+8291055_11162991114.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000434480+829631_8112991114.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000434480+829829_9452991114.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000442652+8291055_11163231138.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000442652+829631_8113231138.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000442652+829829_9453231138.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000535094+8301055_11162931126.0DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000535094+830631_8112931126.0DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000535094+830829_9452931126.0DomainPH
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000375597+827351_456291985.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000375608+930351_4563231138.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000397030+828351_4563261097.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000421756+828351_4562971068.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000423482+830351_4562911124.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000434480+829351_4562991114.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000442652+829351_4563231138.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803229ENST00000535094+830351_4562931126.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375597+827351_456291985.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375608+930351_4563231138.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000397030+828351_4563261097.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000421756+828351_4562971068.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000423482+830351_4562911124.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000434480+829351_4562991114.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000442652+829351_4563231138.0RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000535094+830351_4562931126.0RepeatNote=Spectrin
TgeneF10chr13:113720484chr13:113803229ENST0000037555968125_165288489.0DomainEGF-like 2
TgeneF10chr13:113720484chr13:113803229ENST0000037555968235_467288489.0DomainPeptidase S1
TgeneF10chr13:113720484chr13:113803229ENST000003755596841_85288489.0DomainGla
TgeneF10chr13:113720484chr13:113803229ENST000003755596886_122288489.0DomainEGF-like 1%3B calcium-binding
TgeneF10chr13:113720484chr13:113803230ENST0000037555968125_165288489.0DomainEGF-like 2
TgeneF10chr13:113720484chr13:113803230ENST0000037555968235_467288489.0DomainPeptidase S1
TgeneF10chr13:113720484chr13:113803230ENST000003755596841_85288489.0DomainGla
TgeneF10chr13:113720484chr13:113803230ENST000003755596886_122288489.0DomainEGF-like 1%3B calcium-binding
TgeneF10chr13:113720484chr13:113803229ENST0000037555968183_203288489.0RegionNote=O-glycosylated at one site
TgeneF10chr13:113720484chr13:113803230ENST0000037555968183_203288489.0RegionNote=O-glycosylated at one site


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Fusion Gene Sequence for MCF2L-F10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MCF2L-F10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MCF2L-F10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MCF2L-F10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource