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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MCF2-MYB (FusionGDB2 ID:52188)

Fusion Gene Summary for MCF2-MYB

Fusion gene summary

Fusion gene information	Fusion gene name: MCF2-MYB
	Fusion gene ID: 52188
		Hgene	Tgene
	Gene symbol	MCF2	MYB
	Gene ID	4168	4602
	Gene name	MCF.2 cell line derived transforming sequence	MYB proto-oncogene, transcription factor
	Synonyms	ARHGEF21\|DBL	Cmyb\|c-myb\|c-myb_CDS\|efg
	Cytomap	Xq27.1	6q23.3
	Type of gene	protein-coding	protein-coding
	Description	proto-oncogene DBLOncogene MCF2 (oncogene DBL)proto-oncogene MCF-2	transcriptional activator Myboncogene AMVproto-oncogene c-Mybv-myb avian myeloblastosis viral oncogene homolog
	Modification date	20200313	20200313
	UniProtAcc	P10911	A2RUH7
	Ensembl transtripts involved in fusion gene	ENST00000338585, ENST00000370573, ENST00000370576, ENST00000370578, ENST00000414978, ENST00000483690, ENST00000519895, ENST00000520602, ENST00000536274,	ENST00000316528, ENST00000341911, ENST00000367814, ENST00000420123, ENST00000442647, ENST00000525369, ENST00000527615, ENST00000528774, ENST00000531845, ENST00000533624, ENST00000534044, ENST00000534121,
Fusion gene scores	* DoF score	1 X 1 X 1=1	7 X 7 X 4=196
	# samples	1	8
	** MAII score	log2(1/1*10)=3.32192809488736	log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MCF2 [Title/Abstract] AND MYB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MCF2(138688371)-MYB(135540310), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MYB	GO:0045944	positive regulation of transcription by RNA polymerase II	10233885\|20484083

Fusion gene breakpoints across MCF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AI708084	MCF2	chrX	138688371	-	MYB	chr6	135540310	-

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Fusion Gene ORF analysis for MCF2-MYB

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000338585	ENST00000316528	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000338585	ENST00000341911	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000338585	ENST00000367814	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000338585	ENST00000420123	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000338585	ENST00000442647	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000338585	ENST00000525369	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000338585	ENST00000527615	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000338585	ENST00000528774	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000338585	ENST00000531845	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000338585	ENST00000533624	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000338585	ENST00000534044	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000338585	ENST00000534121	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370573	ENST00000316528	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370573	ENST00000341911	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370573	ENST00000367814	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370573	ENST00000420123	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370573	ENST00000442647	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370573	ENST00000525369	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370573	ENST00000527615	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370573	ENST00000528774	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370573	ENST00000531845	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370573	ENST00000533624	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370573	ENST00000534044	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370573	ENST00000534121	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370576	ENST00000316528	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370576	ENST00000341911	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370576	ENST00000367814	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370576	ENST00000420123	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370576	ENST00000442647	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370576	ENST00000525369	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370576	ENST00000527615	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370576	ENST00000528774	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370576	ENST00000531845	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370576	ENST00000533624	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370576	ENST00000534044	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370576	ENST00000534121	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370578	ENST00000316528	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370578	ENST00000341911	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370578	ENST00000367814	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370578	ENST00000420123	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370578	ENST00000442647	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370578	ENST00000525369	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370578	ENST00000527615	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370578	ENST00000528774	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370578	ENST00000531845	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370578	ENST00000533624	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370578	ENST00000534044	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000370578	ENST00000534121	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000414978	ENST00000316528	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000414978	ENST00000341911	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000414978	ENST00000367814	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000414978	ENST00000420123	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000414978	ENST00000442647	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000414978	ENST00000525369	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000414978	ENST00000527615	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000414978	ENST00000528774	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000414978	ENST00000531845	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000414978	ENST00000533624	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000414978	ENST00000534044	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000414978	ENST00000534121	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000483690	ENST00000316528	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000483690	ENST00000341911	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000483690	ENST00000367814	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000483690	ENST00000420123	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000483690	ENST00000442647	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000483690	ENST00000525369	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000483690	ENST00000527615	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000483690	ENST00000528774	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000483690	ENST00000531845	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000483690	ENST00000533624	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000483690	ENST00000534044	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000483690	ENST00000534121	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000519895	ENST00000316528	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000519895	ENST00000341911	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000519895	ENST00000367814	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000519895	ENST00000420123	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000519895	ENST00000442647	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000519895	ENST00000525369	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000519895	ENST00000527615	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000519895	ENST00000528774	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000519895	ENST00000531845	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000519895	ENST00000533624	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000519895	ENST00000534044	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000519895	ENST00000534121	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000520602	ENST00000316528	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000520602	ENST00000341911	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000520602	ENST00000367814	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000520602	ENST00000420123	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000520602	ENST00000442647	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000520602	ENST00000525369	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000520602	ENST00000527615	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000520602	ENST00000528774	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000520602	ENST00000531845	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000520602	ENST00000533624	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000520602	ENST00000534044	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000520602	ENST00000534121	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000536274	ENST00000316528	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000536274	ENST00000341911	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000536274	ENST00000367814	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000536274	ENST00000420123	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000536274	ENST00000442647	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000536274	ENST00000525369	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000536274	ENST00000527615	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000536274	ENST00000528774	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000536274	ENST00000531845	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000536274	ENST00000533624	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000536274	ENST00000534044	MCF2	chrX	138688371	-	MYB	chr6	135540310	-
intron-intron	ENST00000536274	ENST00000534121	MCF2	chrX	138688371	-	MYB	chr6	135540310	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MCF2-MYB

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MCF2-MYB

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:138688371/:135540310)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MCF2 P10911	MYB A2RUH7
FUNCTION: Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.	FUNCTION: Myosin-binding protein which plays a role in cardiac function (PubMed:28778945). Seems to regulate conduction in the atria and ventricular conduction systems (PubMed:28778945). {ECO:0000269\|PubMed:28778945}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MCF2-MYB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MCF2-MYB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MCF2-MYB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MCF2-MYB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source