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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MCM5-LYN (FusionGDB2 ID:52233)

Fusion Gene Summary for MCM5-LYN

Fusion gene summary

Fusion gene information	Fusion gene name: MCM5-LYN
	Fusion gene ID: 52233
		Hgene	Tgene
	Gene symbol	MCM5	LYN
	Gene ID	4174	4067
	Gene name	minichromosome maintenance complex component 5	LYN proto-oncogene, Src family tyrosine kinase
	Synonyms	CDC46\|MGORS8\|P1-CDC46	JTK8\|p53Lyn\|p56Lyn
	Cytomap	22q12.3	8q12.1
	Type of gene	protein-coding	protein-coding
	Description	DNA replication licensing factor MCM5CDC46 homologMCM5 minichromosome maintenance deficient 5, cell division cycle 46minichromosome maintenance deficient 5 (cell division cycle 46)	tyrosine-protein kinase Lynlck/Yes-related novel protein tyrosine kinasev-yes-1 Yamaguchi sarcoma viral related oncogene homolog
	Modification date	20200315	20200327
	UniProtAcc	P33992	P0DP58
	Ensembl transtripts involved in fusion gene	ENST00000216122, ENST00000382011, ENST00000465557,	ENST00000420292, ENST00000519728, ENST00000520220,
Fusion gene scores	* DoF score	17 X 12 X 7=1428	13 X 14 X 7=1274
	# samples	22	15
	** MAII score	log2(22/1428*10)=-2.69842055050444 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1274*10)=-3.08633087176042 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MCM5 [Title/Abstract] AND LYN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MCM5(35799535)-LYN(56910905), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	LYN	GO:0006468	protein phosphorylation	11517336
Tgene	LYN	GO:0006974	cellular response to DNA damage stimulus	10891478\|11517336
Tgene	LYN	GO:0018108	peptidyl-tyrosine phosphorylation	7682714\|11782428
Tgene	LYN	GO:0046777	protein autophosphorylation	7682714
Tgene	LYN	GO:0051272	positive regulation of cellular component movement	16467205
Tgene	LYN	GO:0070304	positive regulation of stress-activated protein kinase signaling cascade	10891478

Fusion gene breakpoints across MCM5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LYN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-25-1329-01A	MCM5	chr22	35799535	-	LYN	chr8	56910905	+
ChimerDB4	OV	TCGA-25-1329-01A	MCM5	chr22	35799535	+	LYN	chr8	56910905	+
ChimerDB4	OV	TCGA-25-1329	MCM5	chr22	35799535	+	LYN	chr8	56910904	+

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Fusion Gene ORF analysis for MCM5-LYN

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000216122	ENST00000420292	MCM5	chr22	35799535	+	LYN	chr8	56910905	+
5CDS-3UTR	ENST00000216122	ENST00000420292	MCM5	chr22	35799535	+	LYN	chr8	56910904	+
In-frame	ENST00000216122	ENST00000519728	MCM5	chr22	35799535	+	LYN	chr8	56910905	+
In-frame	ENST00000216122	ENST00000519728	MCM5	chr22	35799535	+	LYN	chr8	56910904	+
In-frame	ENST00000216122	ENST00000520220	MCM5	chr22	35799535	+	LYN	chr8	56910905	+
In-frame	ENST00000216122	ENST00000520220	MCM5	chr22	35799535	+	LYN	chr8	56910904	+
intron-3CDS	ENST00000382011	ENST00000519728	MCM5	chr22	35799535	+	LYN	chr8	56910905	+
intron-3CDS	ENST00000382011	ENST00000519728	MCM5	chr22	35799535	+	LYN	chr8	56910904	+
intron-3CDS	ENST00000382011	ENST00000520220	MCM5	chr22	35799535	+	LYN	chr8	56910905	+
intron-3CDS	ENST00000382011	ENST00000520220	MCM5	chr22	35799535	+	LYN	chr8	56910904	+
intron-3CDS	ENST00000465557	ENST00000519728	MCM5	chr22	35799535	+	LYN	chr8	56910905	+
intron-3CDS	ENST00000465557	ENST00000519728	MCM5	chr22	35799535	+	LYN	chr8	56910904	+
intron-3CDS	ENST00000465557	ENST00000520220	MCM5	chr22	35799535	+	LYN	chr8	56910905	+
intron-3CDS	ENST00000465557	ENST00000520220	MCM5	chr22	35799535	+	LYN	chr8	56910904	+
intron-3UTR	ENST00000382011	ENST00000420292	MCM5	chr22	35799535	+	LYN	chr8	56910905	+
intron-3UTR	ENST00000382011	ENST00000420292	MCM5	chr22	35799535	+	LYN	chr8	56910904	+
intron-3UTR	ENST00000465557	ENST00000420292	MCM5	chr22	35799535	+	LYN	chr8	56910905	+
intron-3UTR	ENST00000465557	ENST00000420292	MCM5	chr22	35799535	+	LYN	chr8	56910904	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000216122

MCM5

chr22

35799535

ENST00000519728

LYN

chr8

56910905

1528

577

109

1065

318

ENST00000216122

MCM5

chr22

35799535

ENST00000520220

LYN

chr8

56910905

2337

577

109

1065

318

ENST00000216122

MCM5

chr22

35799535

ENST00000519728

LYN

chr8

56910904

1528

577

109

1065

318

ENST00000216122

MCM5

chr22

35799535

ENST00000520220

LYN

chr8

56910904

2337

577

109

1065

318

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000216122	ENST00000519728	MCM5	chr22	35799535	+	LYN	chr8	56910905	+	0.003773092	0.9962269
ENST00000216122	ENST00000520220	MCM5	chr22	35799535	+	LYN	chr8	56910905	+	0.002383934	0.99761605
ENST00000216122	ENST00000519728	MCM5	chr22	35799535	+	LYN	chr8	56910904	+	0.003773092	0.9962269
ENST00000216122	ENST00000520220	MCM5	chr22	35799535	+	LYN	chr8	56910904	+	0.002383934	0.99761605

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Fusion Genomic Features for MCM5-LYN

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MCM5-LYN

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:35799535/chr8:56910905)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MCM5 P33992	LYN P0DP58
FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. {ECO:0000269\|PubMed:16899510}.	FUNCTION: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:21252236). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR (By similarity). In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs (PubMed:28100642). Prevents plasticity in the primary visual cortex late in life (By similarity). {ECO:0000250\|UniProtKB:P0DP60, ECO:0000269\|PubMed:21252236, ECO:0000269\|PubMed:28100642}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MCM5

chr22:35799535

chr8:56910904

ENST00000216122

331_537

141

735.0

Domain

Note=MCM

Hgene

MCM5

chr22:35799535

chr8:56910905

ENST00000216122

331_537

141

735.0

Domain

Note=MCM

Hgene

MCM5

chr22:35799535

chr8:56910904

ENST00000216122

381_388

141

735.0

Nucleotide binding

ATP

Hgene

MCM5

chr22:35799535

chr8:56910905

ENST00000216122

381_388

141

735.0

Nucleotide binding

ATP

Tgene

LYN

chr22:35799535

chr8:56910904

ENST00000519728

129_226

350

513.0

Domain

SH2

Tgene

LYN

chr22:35799535

chr8:56910904

ENST00000519728

247_501

350

513.0

Domain

Protein kinase

Tgene

LYN

chr22:35799535

chr8:56910904

ENST00000519728

63_123

350

513.0

Domain

SH3

Tgene

LYN

chr22:35799535

chr8:56910904

ENST00000520220

129_226

329

492.0

Domain

SH2

Tgene

LYN

chr22:35799535

chr8:56910904

ENST00000520220

247_501

329

492.0

Domain

Protein kinase

Tgene

LYN

chr22:35799535

chr8:56910904

ENST00000520220

63_123

329

492.0

Domain

SH3

Tgene

LYN

chr22:35799535

chr8:56910905

ENST00000519728

129_226

350

513.0

Domain

SH2

Tgene

LYN

chr22:35799535

chr8:56910905

ENST00000519728

247_501

350

513.0

Domain

Protein kinase

Tgene

LYN

chr22:35799535

chr8:56910905

ENST00000519728

63_123

350

513.0

Domain

SH3

Tgene

LYN

chr22:35799535

chr8:56910905

ENST00000520220

129_226

329

492.0

Domain

SH2

Tgene

LYN

chr22:35799535

chr8:56910905

ENST00000520220

247_501

329

492.0

Domain

Protein kinase

Tgene

LYN

chr22:35799535

chr8:56910905

ENST00000520220

63_123

329

492.0

Domain

SH3

Tgene

LYN

chr22:35799535

chr8:56910904

ENST00000519728

253_261

350

513.0

Nucleotide binding

ATP

Tgene

LYN

chr22:35799535

chr8:56910904

ENST00000520220

253_261

329

492.0

Nucleotide binding

ATP

Tgene

LYN

chr22:35799535

chr8:56910905

ENST00000519728

253_261

350

513.0

Nucleotide binding

ATP

Tgene

LYN

chr22:35799535

chr8:56910905

ENST00000520220

253_261

329

492.0

Nucleotide binding

ATP

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Fusion Gene Sequence for MCM5-LYN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>52233_52233_1_MCM5-LYN_MCM5_chr22_35799535_ENST00000216122_LYN_chr8_56910904_ENST00000519728_length(transcript)=1528nt_BP=577nt
AATCGCTGGCCGCGAGGCTCCGGCGAACCAATGGGAGCGCAGCGGCTGCGGCGTCCGAACACCGCCTCTTGTTTTTCCCGCGAAACTCGG
CGGCTGAGCGTGGAGGTTCTTGTCTCCCCTGGTTTGTGAAGTGCGGAAAACCAGAGGCGCAGTCATGTCGGGATTCGACGATCCTGGCAT
TTTCTACAGCGACAGCTTCGGGGGCGACGCCCAGGCCGACGAGGGGCAGGCCCGCAAATCGCAGCTGCAGAGGCGCTTCAAGGAGTTCCT
GCGGCAGTACCGAGTGGGCACCGACCGCACGGGCTTCACCTTCAAATACAGGGATGAACTCAAGCGGCATTACAACCTGGGGGAGTACTG
GATTGAGGTGGAGATGGAGGATCTGGCCAGCTTTGATGAGGACCTGGCCGACTACTTGTACAAGCAGCCAGCCGAGCACCTGCAGCTGCT
GGAGGAAGCTGCCAAGGAGGTAGCTGATGAGGTGACCCGGCCCCGGCCTTCTGGGGAGGAGGTGCTCCAGGACATCCAGGTCATGCTCAA
GTCGGACGCCAGCCCTTCCAGCATTCGTAGCCTGAAGATTGCAGAGGGAATGGCATACATCGAGCGGAAGAACTACATTCACCGGGACCT
GCGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGCAAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAATGAGTACAC
AGCAAGGGAAGGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACTATTAAGTCTGATGTGTGGTC
CTTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAAATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGCCCTGTCCCA
GGGCTACAGGATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAAGAAAAGGCAGAAGAGAGACC
AACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTACACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAGAGCACAGGGAGACC
CGTCCATTTGGCAGGGGTGGCTGCCTCATTTAGAGAGGAAAAGTAACCATCACTGGTTGCACTTATGATTTCATGTGCGGGGATCATCTG
CCGTGCCTGGATCCTGAAATAGAGGCTAAATTACTCAGGAAGAACACCCTCTAAATGGGAAAGTATTCTGTACTCTTAGATGGATTCTCC
ACTCAGTTGCAACTTGGACTTGTCCTCAGCAGCTGGTAATCTTGCTCTGCTTGACAACATCTGAGTGCAGCCGTTTGAGAAGAAAACATC
TATTCTCTCCAAAAATGCACCCAACTAGCTCTATGTTTACAAATGGACATAGGACTCAAAGTTTCAGAGACCATTGCAATGAATCCCCAA

>52233_52233_1_MCM5-LYN_MCM5_chr22_35799535_ENST00000216122_LYN_chr8_56910904_ENST00000519728_length(amino acids)=318AA_BP=156
MSPLVCEVRKTRGAVMSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEME
DLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKIAEGMAYIERKNYIHRDLRAANVL
VSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPR

--------------------------------------------------------------
>52233_52233_2_MCM5-LYN_MCM5_chr22_35799535_ENST00000216122_LYN_chr8_56910904_ENST00000520220_length(transcript)=2337nt_BP=577nt
AATCGCTGGCCGCGAGGCTCCGGCGAACCAATGGGAGCGCAGCGGCTGCGGCGTCCGAACACCGCCTCTTGTTTTTCCCGCGAAACTCGG
CGGCTGAGCGTGGAGGTTCTTGTCTCCCCTGGTTTGTGAAGTGCGGAAAACCAGAGGCGCAGTCATGTCGGGATTCGACGATCCTGGCAT
TTTCTACAGCGACAGCTTCGGGGGCGACGCCCAGGCCGACGAGGGGCAGGCCCGCAAATCGCAGCTGCAGAGGCGCTTCAAGGAGTTCCT
GCGGCAGTACCGAGTGGGCACCGACCGCACGGGCTTCACCTTCAAATACAGGGATGAACTCAAGCGGCATTACAACCTGGGGGAGTACTG
GATTGAGGTGGAGATGGAGGATCTGGCCAGCTTTGATGAGGACCTGGCCGACTACTTGTACAAGCAGCCAGCCGAGCACCTGCAGCTGCT
GGAGGAAGCTGCCAAGGAGGTAGCTGATGAGGTGACCCGGCCCCGGCCTTCTGGGGAGGAGGTGCTCCAGGACATCCAGGTCATGCTCAA
GTCGGACGCCAGCCCTTCCAGCATTCGTAGCCTGAAGATTGCAGAGGGAATGGCATACATCGAGCGGAAGAACTACATTCACCGGGACCT
GCGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGCAAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAATGAGTACAC
AGCAAGGGAAGGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACTATTAAGTCTGATGTGTGGTC
CTTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAAATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGCCCTGTCCCA
GGGCTACAGGATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAAGAAAAGGCAGAAGAGAGACC
AACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTACACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAGAGCACAGGGAGACC
CGTCCATTTGGCAGGGGTGGCTGCCTCATTTAGAGAGGAAAAGTAACCATCACTGGTTGCACTTATGATTTCATGTGCGGGGATCATCTG
CCGTGCCTGGATCCTGAAATAGAGGCTAAATTACTCAGGAAGAACACCCTCTAAATGGGAAAGTATTCTGTACTCTTAGATGGATTCTCC
ACTCAGTTGCAACTTGGACTTGTCCTCAGCAGCTGGTAATCTTGCTCTGCTTGACAACATCTGAGTGCAGCCGTTTGAGAAGAAAACATC
TATTCTCTCCAAAAATGCACCCAACTAGCTCTATGTTTACAAATGGACATAGGACTCAAAGTTTCAGAGACCATTGCAATGAATCCCCAA
TAATTGCAGAACTAAACTCATTTATAAAGCTAAAATAACCGGATATATACATAGCATGACATTTCTTTGTGCTTTGGCTTACTTGTTTAA
AAAAAAAAAAAAACTAATCCAACCTGTTAGATTTTGCAGGTGAAGTCAGCAGCTTAAAAATGTCTTTCCCAGATTTCAATGATTTTTTTC
CCCCTACCTCCCAAAATCTGAGACTGTTAAAACATTTTTCTTCTATGAACACTGCTCAGACCTGCTAGACATGCCATAGGAGTGGCGTGC
ACATCTCTCTCTCTTCCAGCAGGAGGAGCCCGTGAGCACGCACAGCTGCCCTGTCTGCTCACCCGAAGGCACCGGGCTCACCTGGACCTC
CCAGGAAAGGGAGAAGAGCCTCAGAAACTGCTCTGTGTTTAGAAGGAATATTTTTAAGAGTCCAGCTTTTTCATTTCCACAATTTCCTAT
ATCCAGATTTGTTTTGACAATGTAGTTTGGAAGAACTAAGATTCTAATCTCTGAAGAACCTTATAGGGCCTTCTAAAACATAAGAGTTTC
CTTTGTTGCTTCAAATATTTGAACATTATGTTAAAGATCAAGTATTAATTTTAGTTGTACTCTAGAAAGCTAAAGTGCCACATTCGGGGC
TATTTTTATGATTCAGCAATCTTTTCTAAATTGTGTAGCATGTGTATGAGACTATTTATACCCAAGGATATGAAGGAACATAAGTGACTA
CAAGGCTCTAATAAGCCACGGTGGCAGGAGGTTCAAGCGGTTCTGTTCACTAAATTTTTCTCCTGTAAGCTTTGAATGGAAACTTCTGTA

>52233_52233_2_MCM5-LYN_MCM5_chr22_35799535_ENST00000216122_LYN_chr8_56910904_ENST00000520220_length(amino acids)=318AA_BP=156
MSPLVCEVRKTRGAVMSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEME
DLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKIAEGMAYIERKNYIHRDLRAANVL
VSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPR

--------------------------------------------------------------
>52233_52233_3_MCM5-LYN_MCM5_chr22_35799535_ENST00000216122_LYN_chr8_56910905_ENST00000519728_length(transcript)=1528nt_BP=577nt
AATCGCTGGCCGCGAGGCTCCGGCGAACCAATGGGAGCGCAGCGGCTGCGGCGTCCGAACACCGCCTCTTGTTTTTCCCGCGAAACTCGG
CGGCTGAGCGTGGAGGTTCTTGTCTCCCCTGGTTTGTGAAGTGCGGAAAACCAGAGGCGCAGTCATGTCGGGATTCGACGATCCTGGCAT
TTTCTACAGCGACAGCTTCGGGGGCGACGCCCAGGCCGACGAGGGGCAGGCCCGCAAATCGCAGCTGCAGAGGCGCTTCAAGGAGTTCCT
GCGGCAGTACCGAGTGGGCACCGACCGCACGGGCTTCACCTTCAAATACAGGGATGAACTCAAGCGGCATTACAACCTGGGGGAGTACTG
GATTGAGGTGGAGATGGAGGATCTGGCCAGCTTTGATGAGGACCTGGCCGACTACTTGTACAAGCAGCCAGCCGAGCACCTGCAGCTGCT
GGAGGAAGCTGCCAAGGAGGTAGCTGATGAGGTGACCCGGCCCCGGCCTTCTGGGGAGGAGGTGCTCCAGGACATCCAGGTCATGCTCAA
GTCGGACGCCAGCCCTTCCAGCATTCGTAGCCTGAAGATTGCAGAGGGAATGGCATACATCGAGCGGAAGAACTACATTCACCGGGACCT
GCGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGCAAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAATGAGTACAC
AGCAAGGGAAGGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACTATTAAGTCTGATGTGTGGTC
CTTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAAATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGCCCTGTCCCA
GGGCTACAGGATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAAGAAAAGGCAGAAGAGAGACC
AACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTACACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAGAGCACAGGGAGACC
CGTCCATTTGGCAGGGGTGGCTGCCTCATTTAGAGAGGAAAAGTAACCATCACTGGTTGCACTTATGATTTCATGTGCGGGGATCATCTG
CCGTGCCTGGATCCTGAAATAGAGGCTAAATTACTCAGGAAGAACACCCTCTAAATGGGAAAGTATTCTGTACTCTTAGATGGATTCTCC
ACTCAGTTGCAACTTGGACTTGTCCTCAGCAGCTGGTAATCTTGCTCTGCTTGACAACATCTGAGTGCAGCCGTTTGAGAAGAAAACATC
TATTCTCTCCAAAAATGCACCCAACTAGCTCTATGTTTACAAATGGACATAGGACTCAAAGTTTCAGAGACCATTGCAATGAATCCCCAA

>52233_52233_3_MCM5-LYN_MCM5_chr22_35799535_ENST00000216122_LYN_chr8_56910905_ENST00000519728_length(amino acids)=318AA_BP=156
MSPLVCEVRKTRGAVMSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEME
DLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKIAEGMAYIERKNYIHRDLRAANVL
VSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPR

--------------------------------------------------------------
>52233_52233_4_MCM5-LYN_MCM5_chr22_35799535_ENST00000216122_LYN_chr8_56910905_ENST00000520220_length(transcript)=2337nt_BP=577nt
AATCGCTGGCCGCGAGGCTCCGGCGAACCAATGGGAGCGCAGCGGCTGCGGCGTCCGAACACCGCCTCTTGTTTTTCCCGCGAAACTCGG
CGGCTGAGCGTGGAGGTTCTTGTCTCCCCTGGTTTGTGAAGTGCGGAAAACCAGAGGCGCAGTCATGTCGGGATTCGACGATCCTGGCAT
TTTCTACAGCGACAGCTTCGGGGGCGACGCCCAGGCCGACGAGGGGCAGGCCCGCAAATCGCAGCTGCAGAGGCGCTTCAAGGAGTTCCT
GCGGCAGTACCGAGTGGGCACCGACCGCACGGGCTTCACCTTCAAATACAGGGATGAACTCAAGCGGCATTACAACCTGGGGGAGTACTG
GATTGAGGTGGAGATGGAGGATCTGGCCAGCTTTGATGAGGACCTGGCCGACTACTTGTACAAGCAGCCAGCCGAGCACCTGCAGCTGCT
GGAGGAAGCTGCCAAGGAGGTAGCTGATGAGGTGACCCGGCCCCGGCCTTCTGGGGAGGAGGTGCTCCAGGACATCCAGGTCATGCTCAA
GTCGGACGCCAGCCCTTCCAGCATTCGTAGCCTGAAGATTGCAGAGGGAATGGCATACATCGAGCGGAAGAACTACATTCACCGGGACCT
GCGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGCAAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAATGAGTACAC
AGCAAGGGAAGGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACTATTAAGTCTGATGTGTGGTC
CTTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAAATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGCCCTGTCCCA
GGGCTACAGGATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAAGAAAAGGCAGAAGAGAGACC
AACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTACACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAGAGCACAGGGAGACC
CGTCCATTTGGCAGGGGTGGCTGCCTCATTTAGAGAGGAAAAGTAACCATCACTGGTTGCACTTATGATTTCATGTGCGGGGATCATCTG
CCGTGCCTGGATCCTGAAATAGAGGCTAAATTACTCAGGAAGAACACCCTCTAAATGGGAAAGTATTCTGTACTCTTAGATGGATTCTCC
ACTCAGTTGCAACTTGGACTTGTCCTCAGCAGCTGGTAATCTTGCTCTGCTTGACAACATCTGAGTGCAGCCGTTTGAGAAGAAAACATC
TATTCTCTCCAAAAATGCACCCAACTAGCTCTATGTTTACAAATGGACATAGGACTCAAAGTTTCAGAGACCATTGCAATGAATCCCCAA
TAATTGCAGAACTAAACTCATTTATAAAGCTAAAATAACCGGATATATACATAGCATGACATTTCTTTGTGCTTTGGCTTACTTGTTTAA
AAAAAAAAAAAAACTAATCCAACCTGTTAGATTTTGCAGGTGAAGTCAGCAGCTTAAAAATGTCTTTCCCAGATTTCAATGATTTTTTTC
CCCCTACCTCCCAAAATCTGAGACTGTTAAAACATTTTTCTTCTATGAACACTGCTCAGACCTGCTAGACATGCCATAGGAGTGGCGTGC
ACATCTCTCTCTCTTCCAGCAGGAGGAGCCCGTGAGCACGCACAGCTGCCCTGTCTGCTCACCCGAAGGCACCGGGCTCACCTGGACCTC
CCAGGAAAGGGAGAAGAGCCTCAGAAACTGCTCTGTGTTTAGAAGGAATATTTTTAAGAGTCCAGCTTTTTCATTTCCACAATTTCCTAT
ATCCAGATTTGTTTTGACAATGTAGTTTGGAAGAACTAAGATTCTAATCTCTGAAGAACCTTATAGGGCCTTCTAAAACATAAGAGTTTC
CTTTGTTGCTTCAAATATTTGAACATTATGTTAAAGATCAAGTATTAATTTTAGTTGTACTCTAGAAAGCTAAAGTGCCACATTCGGGGC
TATTTTTATGATTCAGCAATCTTTTCTAAATTGTGTAGCATGTGTATGAGACTATTTATACCCAAGGATATGAAGGAACATAAGTGACTA
CAAGGCTCTAATAAGCCACGGTGGCAGGAGGTTCAAGCGGTTCTGTTCACTAAATTTTTCTCCTGTAAGCTTTGAATGGAAACTTCTGTA

>52233_52233_4_MCM5-LYN_MCM5_chr22_35799535_ENST00000216122_LYN_chr8_56910905_ENST00000520220_length(amino acids)=318AA_BP=156
MSPLVCEVRKTRGAVMSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEME
DLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKIAEGMAYIERKNYIHRDLRAANVL
VSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MCM5-LYN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MCM5-LYN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MCM5-LYN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source