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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MCM5-RALGAPB (FusionGDB2 ID:52242)

Fusion Gene Summary for MCM5-RALGAPB

check button Fusion gene summary
Fusion gene informationFusion gene name: MCM5-RALGAPB
Fusion gene ID: 52242
HgeneTgene
Gene symbol

MCM5

RALGAPB

Gene ID

4174

57148

Gene nameminichromosome maintenance complex component 5Ral GTPase activating protein non-catalytic subunit beta
SynonymsCDC46|MGORS8|P1-CDC46KIAA1219|RalGAPbeta
Cytomap

22q12.3

20q11.23

Type of geneprotein-codingprotein-coding
DescriptionDNA replication licensing factor MCM5CDC46 homologMCM5 minichromosome maintenance deficient 5, cell division cycle 46minichromosome maintenance deficient 5 (cell division cycle 46)ral GTPase-activating protein subunit betaRal GTPase activating protein non-catalytic beta subunitRal GTPase activating protein, beta subunit (non-catalytic)
Modification date2020031520200313
UniProtAcc

P33992

.
Ensembl transtripts involved in fusion geneENST00000216122, ENST00000382011, 
ENST00000465557, 		ENST00000397040, 
ENST00000490114, ENST00000537204, 
ENST00000262879, ENST00000397038, 
ENST00000397042, 
Fusion gene scores* DoF score17 X 12 X 7=14283 X 3 X 3=27
# samples 223
** MAII scorelog2(22/1428*10)=-2.69842055050444
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MCM5 [Title/Abstract] AND RALGAPB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMCM5(35799535)-RALGAPB(37182510), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MCM5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RALGAPB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0C0-01AMCM5chr22

35799535

-RALGAPBchr20

37182510

+
ChimerDB4BRCATCGA-BH-A0C0-01AMCM5chr22

35799535

+RALGAPBchr20

37182510

+


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Fusion Gene ORF analysis for MCM5-RALGAPB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000216122ENST00000397040MCM5chr22

35799535

+RALGAPBchr20

37182510

+
5CDS-intronENST00000216122ENST00000490114MCM5chr22

35799535

+RALGAPBchr20

37182510

+
5CDS-intronENST00000216122ENST00000537204MCM5chr22

35799535

+RALGAPBchr20

37182510

+
In-frameENST00000216122ENST00000262879MCM5chr22

35799535

+RALGAPBchr20

37182510

+
In-frameENST00000216122ENST00000397038MCM5chr22

35799535

+RALGAPBchr20

37182510

+
In-frameENST00000216122ENST00000397042MCM5chr22

35799535

+RALGAPBchr20

37182510

+
intron-3CDSENST00000382011ENST00000262879MCM5chr22

35799535

+RALGAPBchr20

37182510

+
intron-3CDSENST00000382011ENST00000397038MCM5chr22

35799535

+RALGAPBchr20

37182510

+
intron-3CDSENST00000382011ENST00000397042MCM5chr22

35799535

+RALGAPBchr20

37182510

+
intron-3CDSENST00000465557ENST00000262879MCM5chr22

35799535

+RALGAPBchr20

37182510

+
intron-3CDSENST00000465557ENST00000397038MCM5chr22

35799535

+RALGAPBchr20

37182510

+
intron-3CDSENST00000465557ENST00000397042MCM5chr22

35799535

+RALGAPBchr20

37182510

+
intron-intronENST00000382011ENST00000397040MCM5chr22

35799535

+RALGAPBchr20

37182510

+
intron-intronENST00000382011ENST00000490114MCM5chr22

35799535

+RALGAPBchr20

37182510

+
intron-intronENST00000382011ENST00000537204MCM5chr22

35799535

+RALGAPBchr20

37182510

+
intron-intronENST00000465557ENST00000397040MCM5chr22

35799535

+RALGAPBchr20

37182510

+
intron-intronENST00000465557ENST00000490114MCM5chr22

35799535

+RALGAPBchr20

37182510

+
intron-intronENST00000465557ENST00000537204MCM5chr22

35799535

+RALGAPBchr20

37182510

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000216122MCM5chr2235799535+ENST00000262879RALGAPBchr2037182510+57925771091899596
ENST00000216122MCM5chr2235799535+ENST00000397042RALGAPBchr2037182510+57955771091902597
ENST00000216122MCM5chr2235799535+ENST00000397038RALGAPBchr2037182510+57975771091902597

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000216122ENST00000262879MCM5chr2235799535+RALGAPBchr2037182510+0.0001045090.99989545
ENST00000216122ENST00000397042MCM5chr2235799535+RALGAPBchr2037182510+0.0001028510.9998971
ENST00000216122ENST00000397038MCM5chr2235799535+RALGAPBchr2037182510+0.0001020990.99989784

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Fusion Genomic Features for MCM5-RALGAPB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MCM5-RALGAPB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:35799535/chr20:37182510)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MCM5

P33992

.
FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. {ECO:0000269|PubMed:16899510}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRALGAPBchr22:35799535chr20:37182510ENST0000026287920301149_139210541495.0DomainRap-GAP
TgeneRALGAPBchr22:35799535chr20:37182510ENST0000039703820301149_13928321274.0DomainRap-GAP
TgeneRALGAPBchr22:35799535chr20:37182510ENST0000039704020301149_139210541495.0DomainRap-GAP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCM5chr22:35799535chr20:37182510ENST00000216122+417331_537141735.0DomainNote=MCM
HgeneMCM5chr22:35799535chr20:37182510ENST00000216122+417381_388141735.0Nucleotide bindingATP


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Fusion Gene Sequence for MCM5-RALGAPB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52242_52242_1_MCM5-RALGAPB_MCM5_chr22_35799535_ENST00000216122_RALGAPB_chr20_37182510_ENST00000262879_length(transcript)=5792nt_BP=577nt
AATCGCTGGCCGCGAGGCTCCGGCGAACCAATGGGAGCGCAGCGGCTGCGGCGTCCGAACACCGCCTCTTGTTTTTCCCGCGAAACTCGG
CGGCTGAGCGTGGAGGTTCTTGTCTCCCCTGGTTTGTGAAGTGCGGAAAACCAGAGGCGCAGTCATGTCGGGATTCGACGATCCTGGCAT
TTTCTACAGCGACAGCTTCGGGGGCGACGCCCAGGCCGACGAGGGGCAGGCCCGCAAATCGCAGCTGCAGAGGCGCTTCAAGGAGTTCCT
GCGGCAGTACCGAGTGGGCACCGACCGCACGGGCTTCACCTTCAAATACAGGGATGAACTCAAGCGGCATTACAACCTGGGGGAGTACTG
GATTGAGGTGGAGATGGAGGATCTGGCCAGCTTTGATGAGGACCTGGCCGACTACTTGTACAAGCAGCCAGCCGAGCACCTGCAGCTGCT
GGAGGAAGCTGCCAAGGAGGTAGCTGATGAGGTGACCCGGCCCCGGCCTTCTGGGGAGGAGGTGCTCCAGGACATCCAGGTCATGCTCAA
GTCGGACGCCAGCCCTTCCAGCATTCGTAGCCTGAAGTTAGAAGAGAGACACGAAAAATTAAGGAGTGGCATGGCCCAGCAGATTGCTTA
TGAAATACACCTTGAGCAACAGAGTGAGGAGGAATTGCAGAAGAGAAGTTTTCCTGACCCAGTTACGGATTGCAAGCCCCCGCCTCCTGC
CCAGGAATTCCAAACAGCCCGCCTTTTTCTCTCACACTTTGGATTTTTGTCCTTAGAAGCACTGAAGGAACCTGCAAATAGTCGTCTACC
TCCTCACCTTATTGCACTTGATTCCACGATACCTGGATTTTTTGATGACATTGGGTATCTGGATCTCTTGCCATGTCGTCCTTTTGACAC
AGTTTTTATTTTCTATATGAAGCCAGGTCAGAAAACGAACCAAGAGATTTTAAAGAATGTGGAGTCTTCCAGAACTGTTCAGCCACATTT
CCTAGAATTTTTGCTTTCCCTTGGCTGGTCAGTAGATGTGGGCAGACACCCTGGTTGGACTGGGCATGTTTCTACCAGTTGGTCTATTAA
TTGTTGTGATGATGGTGAAGGATCTCAACAAGAAGTGATTTCCTCTGAAGATATTGGAGCTAGCATTTTCAATGGACAGAAGAAGGTGCT
GTATTATGCTGATGCCCTTACAGAAATTGCTTTTGTGGTTCCTTCTCCTGTGGAGTCCTTAACTGATTCATTGGAAAGTAACATCTCGGA
CCAAGATAGTGATTCAAATATGGATCTTATGCCAGGAATTCTGAAACAGCCATCCCTGACACTTGAGCTTTTCCCCAATCATACAGACAA
TCTTAATTCCTCACAGAGGCTCAGTCCCAGTTCCAGAATGAGGAAGCTGCCTCAGGGTCGCCCTGTTCCTCCCCTTGGACCTGAGACAAG
AGTTTCTGTAGTCTGGGTGGAACGCTATGATGATATAGAAAACTTTCCCCTCTCAGAGCTGATGACAGAGATCAGTACTGGTGTGGAAAC
TACTGCAAATAGTAGCACTTCACTGAGATCTACAACTCTTGAAAAAGAAGTTCCTGTCATCTTCATCCACCCTTTAAACACTGGATTATT
CCGGATAAAAATTCAAGGAGCCACTGGAAAATTTAATATGGTCATCCCTCTTGTGGATGGGATGATTGTCAGCAGGCGAGCTCTTGGCTT
TCTGGTGAGGCAGACTGTAATTAACATTTGTAGAAGAAAGAGACTGGAAAGTGACTCCTACAGTCCCCCCCATGTCCGCCGGAAACAGAA
AATCACCGACATTGTCAACAAGTACCGGAACAAGCAGCTGGAGCCAGAGTTTTATACTTCACTTTTCCAGGAGGTTGGACTCAAGAACTG
CAGTTCTTAGACCACTGAATTTCTAAGACTGTTGAACTCCAGTTTGGGAACTATAACACAGCAGAACAGTTTGATAGGTGATCACTGTAA
AAATAAAAACAAATCACTCCCAAGAGCTTACTGTTTAATCACCAGAATAGAAGAAACACATTATAACCCATTTGATAGAAGACTTTGGGC
TATCTAGTGAAATGGGCTCCCAGACACAATCACACTCCTGCTGATAATGATGATATACATTTTAGCCATAAACTTTCTTTTAAAAGTGAC
AATTTTAGTTAAACATAAGCCTTTTGAGGAGAAAGGCTTTTATGCATCTCAGTTAAACACGTGCATTGGTAGTATCAACAAATTTGCAAT
ATAGAAGTTGAAGATAGTTTTTTACCTCACTTTTTAGGAGGTTGTATTCAAAATTAAAATCTCAGAATCTTACAGGACATTTAAAGACTC
ATGTTGATAGCATGGAGGAGAAGGAAAGAAGTCACAGCCTTCTACTCAGTTGTAGGTCTTCTTGTCATCCAGCTGTCACACTGACAAAAA
GAAAAGATGATACATGTTTTTTGCTCAGATAAGAAGCCTGACATTAAAAGATGTCATATTTTTTTCTCCACATTTCAAAAAGTTGTCCTT
CTCATCACTGCACAGATCTGTCTGAAAGCCTCAGTTTCTGAGTGACCCAGGAACAGATCAGAAATGGAGCATGGCCTTGTCCTTTAATGG
GGATGCAAATAAAGTTTGTGGGGTTAAAAGTTATAAGACAGCAGTGATACCCCACTCTCTCCATTATTGTCCAGCGGGGTGACATAATGA
CAGGTTAAATATTTGTGATTCATTGATTAAATATTATTTAAAGAAATGTAAATTCACAATAAGGGTTGAAAATTATTTGGTTTCATCCAT
TGTCTCTTATTTCAGGACCAAGCAGCAAACTGCAGTAGTTTGTGAAGGATTCTAATATGGGGTTCAGGAATAGCCTCTCAACGCTACTAA
TTCAGATCTCTCCCAGAGAACTACTGGATTTCCTCATAATTGACAAACATGAGTGACCACCTCTTTGGGTGGCTACTGTTAGAAATGGCT
GTTGTCATGTTTTCTGGACTTTGCCAGCCAACAGATCCCTGCCAGGTTTTGGAAATACTTCTATTACCTCGCTGCTACTTTTCTGCAGGG
ATAAAACTTTTGAGGTGGCCAGACCCAGAACATCCAAGGATTCCTGTTACAGTGCTACAGTATACACTGCTCATTTATCCTATTCTCATG
TGCTTTCTTCTTTAGTAAGATTATTTTAAGAAAATAAGTGATATTTAAAGTCCAAAGAGGAATGATCACAGTTGTATAAGGGGTGTTTTC
CCACTTGAACTCTGATGTCAGTCGACTGTGGGTCAGAGCTACAACCATCTGTTTGGTTTGATGTTTTGGTGGTTTACTTACGGAGTGGGG
ATAGTGTGAGACCTAATTCCCTGTGCAAATGTCTCTTATTCCAGAAATGTGCATTTTGTCATCTATAAGCAAGAAATATGGGCATAGCAG
CTCTTGGTTTAAAGTTTGCCATAACCTGTTCATGTTTGTTTTAAGCTCAGGTAAAGATAACCTCCTCTTTCTATGACTCCAGTTTCCATT
CAGGTTATAGTATTATTCAATAGTTGATTTTCTTTTTAAGCTGGGCAATAAATTGATGTTTCCAGATGGTAACATGGGAGAGGGCATATA
GGATAAAGATGAGCAAATTCTACCCTAAAAATGTTCTAGTAGTTCACAGGAAGAAGATGAGGTTTAATAACTTTCAAGGTAATTCTAGAT
TGACATTTTGAGGGGAAAATGGGCTCTTGTTCTAGTTGAAGTGAGCAGAGAAGGCTATAAATTAATATGTAACTTACAGCATTCCAGAGG
TTAAAAATAACTGATGCAGATGTACTTCTTCAGTGTGATTCTTCAGATCAAACTTTTACTTTTGGCATAGTTAATTTCAGAAAAATGTGC
TGTATGTGTGTGTGTATGAGGGTTGGTCTTGCTGATCCTTCAGTTAGCTCTAAATTCTGGCAACTCCTTGTAATTCCAATGTATTTGATA
CATGAACAATCATGTTGAATGCATTTGTGATCTGGGAGACTTCCTCGTCTTCCAGGGAAGGAAGGATGTGCAGCCCCTGAAGGCATGAAA
CTCCCAGTGTGTACGGAGCCAGTGGAATATGGGATACCCATACCTTACCAGGCGCTGGTTCCTTCTGCTCACAATAACATCTGCCCAAAG
AGGGAGTGGGAAGAACGCTTAGCTCTTTCACTAGTATGGATTTGAGTTCATGGTCACTATTTTTACCCACCTGCCTTTGTTAAAAATCAC
TTTGAGTAGAATAGCACTGGAGGAACATATTTAGCACCTAATATTAATATTTAGTAGTCCATTGATAAATTTGCCAGCATATGTTCTAGC
CTCTGGGGGGAAACCAGGACCACTTTTGTCTGTGGCTTAAACAGTTCAGTTGCTATATCTGTTGGGTATGCCGGGGGTGGATGAGTGTGG
CATTCCGTGAAGAGGAAGGTGGTAAGTAAGGTTTCCCTTCTACTGCCTTCTTAAGTTGCAGGAGGGAGCTTTTCTCCTCCCCTCTGGTTG
GGAGCACTGAGGACAGTGAGGAGGGCTTTTACCTTGTTAATCCTTTCCTTATTTAGCTAGCTTTCCTTTTTGTCTAGGGCTTCCTCTTGA
GACCCTCTTCCATCCATTGGGCCTTTGAAAGGACTAATCAGACACACACACACACACACACACACACACACACACTCGCATACTCATGCA
CATTTTCCTTCATTTCCAGATCCTTTATTTCAGAGCAGCCCATTTTCCTCTGGATTCATTGATGAATACAAGTACCCACACCTTTGGCCA
GTAATGTCAGTTACCTGCTGCAGGTTCTGTGTATGAGGCCTTCATGAACGGTTACCTTCTCCATACACTAGGGAAGCATTTGTCAGACTC
TGCAGACTGGGTTCTAGAGAGGCAGAGTCTTTAAGAGTATTCATTTCTTCTGGAAGGTGGAGCTTTACCCAAAGTGGAAGTTAGCCTTGC
TCAAAGATGTGTTTTGTGGTAGGTGGTAAAAATAAATAAATAAATAAATAATAAAAAAAGAAACATGTATTGGAGGTAATTTGACACTGC
TGCTGGCAGTAGTTCTCTATTCACCATTTTAAAGCCCATTCAGGTTCTCTCTTCCTGAAAAGAACTGATTGCTGTGTTTACATGAAATGA
CATTGGAGTCAGATGGTCTGTTTTAAAGATTTCCATGACAGCCTCTTTTCCTGAGTTGGAGAGATTGGAGGTGGTCTATCCGTACGATGT
GGAATCAAACGGTGGGTTTCTTAGTAGCTAAAGAAGCCATGTACTTCTAGTGTGTTTCTCAGAATATCAACTCATGTTCTTCAGATGCTT
TTCTTTTTTTAATGGTGAGGGAAAAGGTATAATTTGGGATTCCACAGTGCCTTGCATATAGTAGGCGCCCAGTAAATACTTGTTGAAGCA
AACCAAGTTTCCCAAGTCCTCATCTCTTATAGTGACCAAGACATCTTTCTCCTCTGAAGGGCTTGGCAGTTGTGGCTAAAAAATAAGCAG
TATCATTATTTGCTTGAAATCATATATACAGTTTGTATGAATTTCAGTATGTTGCCAAGACATGATTTTTTCTTATTGTATTTTCTGTAA
ATATTTCTGGCACTGAACTGTAAAGTAAAGGCAAAGTGTAAATATGAAGGCGTGCCCGTGCCCCTTGCCTCCTGTGTTTCATCTTCGTCG
GTTAGGGAAGAAGGTCCAGAGGTTTGTTTGTATTTATGCCGATCCTTTGTCCAGAAGAAGCCCATGGAATATTGAATGTAATACATTTAG

>52242_52242_1_MCM5-RALGAPB_MCM5_chr22_35799535_ENST00000216122_RALGAPB_chr20_37182510_ENST00000262879_length(amino acids)=596AA_BP=154
MSPLVCEVRKTRGAVMSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEME
DLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKLEERHEKLRSGMAQQIAYEIHLEQ
QSEEELQKRSFPDPVTDCKPPPPAQEFQTARLFLSHFGFLSLEALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFDTVFIFYM
KPGQKTNQEILKNVESSRTVQPHFLEFLLSLGWSVDVGRHPGWTGHVSTSWSINCCDDGEGSQQEVISSEDIGASIFNGQKKVLYYADAL
TEIAFVVPSPVESLTDSLESNISDQDSDSNMDLMPGILKQPSLTLELFPNHTDNLNSSQRLSPSSRMRKLPQGRPVPPLGPETRVSVVWV
ERYDDIENFPLSELMTEISTGVETTANSSTSLRSTTLEKEVPVIFIHPLNTGLFRIKIQGATGKFNMVIPLVDGMIVSRRALGFLVRQTV

--------------------------------------------------------------
>52242_52242_2_MCM5-RALGAPB_MCM5_chr22_35799535_ENST00000216122_RALGAPB_chr20_37182510_ENST00000397038_length(transcript)=5797nt_BP=577nt
AATCGCTGGCCGCGAGGCTCCGGCGAACCAATGGGAGCGCAGCGGCTGCGGCGTCCGAACACCGCCTCTTGTTTTTCCCGCGAAACTCGG
CGGCTGAGCGTGGAGGTTCTTGTCTCCCCTGGTTTGTGAAGTGCGGAAAACCAGAGGCGCAGTCATGTCGGGATTCGACGATCCTGGCAT
TTTCTACAGCGACAGCTTCGGGGGCGACGCCCAGGCCGACGAGGGGCAGGCCCGCAAATCGCAGCTGCAGAGGCGCTTCAAGGAGTTCCT
GCGGCAGTACCGAGTGGGCACCGACCGCACGGGCTTCACCTTCAAATACAGGGATGAACTCAAGCGGCATTACAACCTGGGGGAGTACTG
GATTGAGGTGGAGATGGAGGATCTGGCCAGCTTTGATGAGGACCTGGCCGACTACTTGTACAAGCAGCCAGCCGAGCACCTGCAGCTGCT
GGAGGAAGCTGCCAAGGAGGTAGCTGATGAGGTGACCCGGCCCCGGCCTTCTGGGGAGGAGGTGCTCCAGGACATCCAGGTCATGCTCAA
GTCGGACGCCAGCCCTTCCAGCATTCGTAGCCTGAAGTTAGAAGAGAGACACGAAAAATTAAGGAGTGGCATGGCCCAGCAGATTGCTTA
TGAAATACACCTTGAGCAACAGAGTGAGGAGGAATTGCAGAAGAGAAGTTTTCCTGACCCAGTTACGGATTGCAAGCCCCCGCCTCCTGC
CCAGGAATTCCAAACAGCCCGCCTTTTTCTCTCACACTTTGGATTTTTGTCCTTAGAAGCACTGAAGGAACCTGCAAATAGTCGTCTACC
TCCTCACCTTATTGCACTTGATTCCACGATACCTGGATTTTTTGATGACATTGGGTATCTGGATCTCTTGCCATGTCGTCCTTTTGACAC
AGTTTTTATTTTCTATATGAAGCCAGGTCAGAAAACGAACCAAGAGATTTTAAAGAATGTGGAGTCTTCCAGAACTGTTCAGCCACATTT
CCTAGAATTTTTGCTTTCCCTTGGCTGGTCAGTAGATGTGGGCAGACACCCTGGTTGGACTGGGCATGTTTCTACCAGTTGGTCTATTAA
TTGTTGTGATGATGGTGAAGGATCTCAACAAGAAGAAGTGATTTCCTCTGAAGATATTGGAGCTAGCATTTTCAATGGACAGAAGAAGGT
GCTGTATTATGCTGATGCCCTTACAGAAATTGCTTTTGTGGTTCCTTCTCCTGTGGAGTCCTTAACTGATTCATTGGAAAGTAACATCTC
GGACCAAGATAGTGATTCAAATATGGATCTTATGCCAGGAATTCTGAAACAGCCATCCCTGACACTTGAGCTTTTCCCCAATCATACAGA
CAATCTTAATTCCTCACAGAGGCTCAGTCCCAGTTCCAGAATGAGGAAGCTGCCTCAGGGTCGCCCTGTTCCTCCCCTTGGACCTGAGAC
AAGAGTTTCTGTAGTCTGGGTGGAACGCTATGATGATATAGAAAACTTTCCCCTCTCAGAGCTGATGACAGAGATCAGTACTGGTGTGGA
AACTACTGCAAATAGTAGCACTTCACTGAGATCTACAACTCTTGAAAAAGAAGTTCCTGTCATCTTCATCCACCCTTTAAACACTGGATT
ATTCCGGATAAAAATTCAAGGAGCCACTGGAAAATTTAATATGGTCATCCCTCTTGTGGATGGGATGATTGTCAGCAGGCGAGCTCTTGG
CTTTCTGGTGAGGCAGACTGTAATTAACATTTGTAGAAGAAAGAGACTGGAAAGTGACTCCTACAGTCCCCCCCATGTCCGCCGGAAACA
GAAAATCACCGACATTGTCAACAAGTACCGGAACAAGCAGCTGGAGCCAGAGTTTTATACTTCACTTTTCCAGGAGGTTGGACTCAAGAA
CTGCAGTTCTTAGACCACTGAATTTCTAAGACTGTTGAACTCCAGTTTGGGAACTATAACACAGCAGAACAGTTTGATAGGTGATCACTG
TAAAAATAAAAACAAATCACTCCCAAGAGCTTACTGTTTAATCACCAGAATAGAAGAAACACATTATAACCCATTTGATAGAAGACTTTG
GGCTATCTAGTGAAATGGGCTCCCAGACACAATCACACTCCTGCTGATAATGATGATATACATTTTAGCCATAAACTTTCTTTTAAAAGT
GACAATTTTAGTTAAACATAAGCCTTTTGAGGAGAAAGGCTTTTATGCATCTCAGTTAAACACGTGCATTGGTAGTATCAACAAATTTGC
AATATAGAAGTTGAAGATAGTTTTTTACCTCACTTTTTAGGAGGTTGTATTCAAAATTAAAATCTCAGAATCTTACAGGACATTTAAAGA
CTCATGTTGATAGCATGGAGGAGAAGGAAAGAAGTCACAGCCTTCTACTCAGTTGTAGGTCTTCTTGTCATCCAGCTGTCACACTGACAA
AAAGAAAAGATGATACATGTTTTTTGCTCAGATAAGAAGCCTGACATTAAAAGATGTCATATTTTTTTCTCCACATTTCAAAAAGTTGTC
CTTCTCATCACTGCACAGATCTGTCTGAAAGCCTCAGTTTCTGAGTGACCCAGGAACAGATCAGAAATGGAGCATGGCCTTGTCCTTTAA
TGGGGATGCAAATAAAGTTTGTGGGGTTAAAAGTTATAAGACAGCAGTGATACCCCACTCTCTCCATTATTGTCCAGCGGGGTGACATAA
TGACAGGTTAAATATTTGTGATTCATTGATTAAATATTATTTAAAGAAATGTAAATTCACAATAAGGGTTGAAAATTATTTGGTTTCATC
CATTGTCTCTTATTTCAGGACCAAGCAGCAAACTGCAGTAGTTTGTGAAGGATTCTAATATGGGGTTCAGGAATAGCCTCTCAACGCTAC
TAATTCAGATCTCTCCCAGAGAACTACTGGATTTCCTCATAATTGACAAACATGAGTGACCACCTCTTTGGGTGGCTACTGTTAGAAATG
GCTGTTGTCATGTTTTCTGGACTTTGCCAGCCAACAGATCCCTGCCAGGTTTTGGAAATACTTCTATTACCTCGCTGCTACTTTTCTGCA
GGGATAAAACTTTTGAGGTGGCCAGACCCAGAACATCCAAGGATTCCTGTTACAGTGCTACAGTATACACTGCTCATTTATCCTATTCTC
ATGTGCTTTCTTCTTTAGTAAGATTATTTTAAGAAAATAAGTGATATTTAAAGTCCAAAGAGGAATGATCACAGTTGTATAAGGGGTGTT
TTCCCACTTGAACTCTGATGTCAGTCGACTGTGGGTCAGAGCTACAACCATCTGTTTGGTTTGATGTTTTGGTGGTTTACTTACGGAGTG
GGGATAGTGTGAGACCTAATTCCCTGTGCAAATGTCTCTTATTCCAGAAATGTGCATTTTGTCATCTATAAGCAAGAAATATGGGCATAG
CAGCTCTTGGTTTAAAGTTTGCCATAACCTGTTCATGTTTGTTTTAAGCTCAGGTAAAGATAACCTCCTCTTTCTATGACTCCAGTTTCC
ATTCAGGTTATAGTATTATTCAATAGTTGATTTTCTTTTTAAGCTGGGCAATAAATTGATGTTTCCAGATGGTAACATGGGAGAGGGCAT
ATAGGATAAAGATGAGCAAATTCTACCCTAAAAATGTTCTAGTAGTTCACAGGAAGAAGATGAGGTTTAATAACTTTCAAGGTAATTCTA
GATTGACATTTTGAGGGGAAAATGGGCTCTTGTTCTAGTTGAAGTGAGCAGAGAAGGCTATAAATTAATATGTAACTTACAGCATTCCAG
AGGTTAAAAATAACTGATGCAGATGTACTTCTTCAGTGTGATTCTTCAGATCAAACTTTTACTTTTGGCATAGTTAATTTCAGAAAAATG
TGCTGTATGTGTGTGTGTATGAGGGTTGGTCTTGCTGATCCTTCAGTTAGCTCTAAATTCTGGCAACTCCTTGTAATTCCAATGTATTTG
ATACATGAACAATCATGTTGAATGCATTTGTGATCTGGGAGACTTCCTCGTCTTCCAGGGAAGGAAGGATGTGCAGCCCCTGAAGGCATG
AAACTCCCAGTGTGTACGGAGCCAGTGGAATATGGGATACCCATACCTTACCAGGCGCTGGTTCCTTCTGCTCACAATAACATCTGCCCA
AAGAGGGAGTGGGAAGAACGCTTAGCTCTTTCACTAGTATGGATTTGAGTTCATGGTCACTATTTTTACCCACCTGCCTTTGTTAAAAAT
CACTTTGAGTAGAATAGCACTGGAGGAACATATTTAGCACCTAATATTAATATTTAGTAGTCCATTGATAAATTTGCCAGCATATGTTCT
AGCCTCTGGGGGGAAACCAGGACCACTTTTGTCTGTGGCTTAAACAGTTCAGTTGCTATATCTGTTGGGTATGCCGGGGGTGGATGAGTG
TGGCATTCCGTGAAGAGGAAGGTGGTAAGTAAGGTTTCCCTTCTACTGCCTTCTTAAGTTGCAGGAGGGAGCTTTTCTCCTCCCCTCTGG
TTGGGAGCACTGAGGACAGTGAGGAGGGCTTTTACCTTGTTAATCCTTTCCTTATTTAGCTAGCTTTCCTTTTTGTCTAGGGCTTCCTCT
TGAGACCCTCTTCCATCCATTGGGCCTTTGAAAGGACTAATCAGACACACACACACACACACACACACACACACACACTCGCATACTCAT
GCACATTTTCCTTCATTTCCAGATCCTTTATTTCAGAGCAGCCCATTTTCCTCTGGATTCATTGATGAATACAAGTACCCACACCTTTGG
CCAGTAATGTCAGTTACCTGCTGCAGGTTCTGTGTATGAGGCCTTCATGAACGGTTACCTTCTCCATACACTAGGGAAGCATTTGTCAGA
CTCTGCAGACTGGGTTCTAGAGAGGCAGAGTCTTTAAGAGTATTCATTTCTTCTGGAAGGTGGAGCTTTACCCAAAGTGGAAGTTAGCCT
TGCTCAAAGATGTGTTTTGTGGTAGGTGGTAAAAATAAATAAATAAATAAATAATAAAAAAAGAAACATGTATTGGAGGTAATTTGACAC
TGCTGCTGGCAGTAGTTCTCTATTCACCATTTTAAAGCCCATTCAGGTTCTCTCTTCCTGAAAAGAACTGATTGCTGTGTTTACATGAAA
TGACATTGGAGTCAGATGGTCTGTTTTAAAGATTTCCATGACAGCCTCTTTTCCTGAGTTGGAGAGATTGGAGGTGGTCTATCCGTACGA
TGTGGAATCAAACGGTGGGTTTCTTAGTAGCTAAAGAAGCCATGTACTTCTAGTGTGTTTCTCAGAATATCAACTCATGTTCTTCAGATG
CTTTTCTTTTTTTAATGGTGAGGGAAAAGGTATAATTTGGGATTCCACAGTGCCTTGCATATAGTAGGCGCCCAGTAAATACTTGTTGAA
GCAAACCAAGTTTCCCAAGTCCTCATCTCTTATAGTGACCAAGACATCTTTCTCCTCTGAAGGGCTTGGCAGTTGTGGCTAAAAAATAAG
CAGTATCATTATTTGCTTGAAATCATATATACAGTTTGTATGAATTTCAGTATGTTGCCAAGACATGATTTTTTCTTATTGTATTTTCTG
TAAATATTTCTGGCACTGAACTGTAAAGTAAAGGCAAAGTGTAAATATGAAGGCGTGCCCGTGCCCCTTGCCTCCTGTGTTTCATCTTCG
TCGGTTAGGGAAGAAGGTCCAGAGGTTTGTTTGTATTTATGCCGATCCTTTGTCCAGAAGAAGCCCATGGAATATTGAATGTAATACATT

>52242_52242_2_MCM5-RALGAPB_MCM5_chr22_35799535_ENST00000216122_RALGAPB_chr20_37182510_ENST00000397038_length(amino acids)=597AA_BP=154
MSPLVCEVRKTRGAVMSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEME
DLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKLEERHEKLRSGMAQQIAYEIHLEQ
QSEEELQKRSFPDPVTDCKPPPPAQEFQTARLFLSHFGFLSLEALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFDTVFIFYM
KPGQKTNQEILKNVESSRTVQPHFLEFLLSLGWSVDVGRHPGWTGHVSTSWSINCCDDGEGSQQEEVISSEDIGASIFNGQKKVLYYADA
LTEIAFVVPSPVESLTDSLESNISDQDSDSNMDLMPGILKQPSLTLELFPNHTDNLNSSQRLSPSSRMRKLPQGRPVPPLGPETRVSVVW
VERYDDIENFPLSELMTEISTGVETTANSSTSLRSTTLEKEVPVIFIHPLNTGLFRIKIQGATGKFNMVIPLVDGMIVSRRALGFLVRQT

--------------------------------------------------------------
>52242_52242_3_MCM5-RALGAPB_MCM5_chr22_35799535_ENST00000216122_RALGAPB_chr20_37182510_ENST00000397042_length(transcript)=5795nt_BP=577nt
AATCGCTGGCCGCGAGGCTCCGGCGAACCAATGGGAGCGCAGCGGCTGCGGCGTCCGAACACCGCCTCTTGTTTTTCCCGCGAAACTCGG
CGGCTGAGCGTGGAGGTTCTTGTCTCCCCTGGTTTGTGAAGTGCGGAAAACCAGAGGCGCAGTCATGTCGGGATTCGACGATCCTGGCAT
TTTCTACAGCGACAGCTTCGGGGGCGACGCCCAGGCCGACGAGGGGCAGGCCCGCAAATCGCAGCTGCAGAGGCGCTTCAAGGAGTTCCT
GCGGCAGTACCGAGTGGGCACCGACCGCACGGGCTTCACCTTCAAATACAGGGATGAACTCAAGCGGCATTACAACCTGGGGGAGTACTG
GATTGAGGTGGAGATGGAGGATCTGGCCAGCTTTGATGAGGACCTGGCCGACTACTTGTACAAGCAGCCAGCCGAGCACCTGCAGCTGCT
GGAGGAAGCTGCCAAGGAGGTAGCTGATGAGGTGACCCGGCCCCGGCCTTCTGGGGAGGAGGTGCTCCAGGACATCCAGGTCATGCTCAA
GTCGGACGCCAGCCCTTCCAGCATTCGTAGCCTGAAGTTAGAAGAGAGACACGAAAAATTAAGGAGTGGCATGGCCCAGCAGATTGCTTA
TGAAATACACCTTGAGCAACAGAGTGAGGAGGAATTGCAGAAGAGAAGTTTTCCTGACCCAGTTACGGATTGCAAGCCCCCGCCTCCTGC
CCAGGAATTCCAAACAGCCCGCCTTTTTCTCTCACACTTTGGATTTTTGTCCTTAGAAGCACTGAAGGAACCTGCAAATAGTCGTCTACC
TCCTCACCTTATTGCACTTGATTCCACGATACCTGGATTTTTTGATGACATTGGGTATCTGGATCTCTTGCCATGTCGTCCTTTTGACAC
AGTTTTTATTTTCTATATGAAGCCAGGTCAGAAAACGAACCAAGAGATTTTAAAGAATGTGGAGTCTTCCAGAACTGTTCAGCCACATTT
CCTAGAATTTTTGCTTTCCCTTGGCTGGTCAGTAGATGTGGGCAGACACCCTGGTTGGACTGGGCATGTTTCTACCAGTTGGTCTATTAA
TTGTTGTGATGATGGTGAAGGATCTCAACAAGAAGAAGTGATTTCCTCTGAAGATATTGGAGCTAGCATTTTCAATGGACAGAAGAAGGT
GCTGTATTATGCTGATGCCCTTACAGAAATTGCTTTTGTGGTTCCTTCTCCTGTGGAGTCCTTAACTGATTCATTGGAAAGTAACATCTC
GGACCAAGATAGTGATTCAAATATGGATCTTATGCCAGGAATTCTGAAACAGCCATCCCTGACACTTGAGCTTTTCCCCAATCATACAGA
CAATCTTAATTCCTCACAGAGGCTCAGTCCCAGTTCCAGAATGAGGAAGCTGCCTCAGGGTCGCCCTGTTCCTCCCCTTGGACCTGAGAC
AAGAGTTTCTGTAGTCTGGGTGGAACGCTATGATGATATAGAAAACTTTCCCCTCTCAGAGCTGATGACAGAGATCAGTACTGGTGTGGA
AACTACTGCAAATAGTAGCACTTCACTGAGATCTACAACTCTTGAAAAAGAAGTTCCTGTCATCTTCATCCACCCTTTAAACACTGGATT
ATTCCGGATAAAAATTCAAGGAGCCACTGGAAAATTTAATATGGTCATCCCTCTTGTGGATGGGATGATTGTCAGCAGGCGAGCTCTTGG
CTTTCTGGTGAGGCAGACTGTAATTAACATTTGTAGAAGAAAGAGACTGGAAAGTGACTCCTACAGTCCCCCCCATGTCCGCCGGAAACA
GAAAATCACCGACATTGTCAACAAGTACCGGAACAAGCAGCTGGAGCCAGAGTTTTATACTTCACTTTTCCAGGAGGTTGGACTCAAGAA
CTGCAGTTCTTAGACCACTGAATTTCTAAGACTGTTGAACTCCAGTTTGGGAACTATAACACAGCAGAACAGTTTGATAGGTGATCACTG
TAAAAATAAAAACAAATCACTCCCAAGAGCTTACTGTTTAATCACCAGAATAGAAGAAACACATTATAACCCATTTGATAGAAGACTTTG
GGCTATCTAGTGAAATGGGCTCCCAGACACAATCACACTCCTGCTGATAATGATGATATACATTTTAGCCATAAACTTTCTTTTAAAAGT
GACAATTTTAGTTAAACATAAGCCTTTTGAGGAGAAAGGCTTTTATGCATCTCAGTTAAACACGTGCATTGGTAGTATCAACAAATTTGC
AATATAGAAGTTGAAGATAGTTTTTTACCTCACTTTTTAGGAGGTTGTATTCAAAATTAAAATCTCAGAATCTTACAGGACATTTAAAGA
CTCATGTTGATAGCATGGAGGAGAAGGAAAGAAGTCACAGCCTTCTACTCAGTTGTAGGTCTTCTTGTCATCCAGCTGTCACACTGACAA
AAAGAAAAGATGATACATGTTTTTTGCTCAGATAAGAAGCCTGACATTAAAAGATGTCATATTTTTTTCTCCACATTTCAAAAAGTTGTC
CTTCTCATCACTGCACAGATCTGTCTGAAAGCCTCAGTTTCTGAGTGACCCAGGAACAGATCAGAAATGGAGCATGGCCTTGTCCTTTAA
TGGGGATGCAAATAAAGTTTGTGGGGTTAAAAGTTATAAGACAGCAGTGATACCCCACTCTCTCCATTATTGTCCAGCGGGGTGACATAA
TGACAGGTTAAATATTTGTGATTCATTGATTAAATATTATTTAAAGAAATGTAAATTCACAATAAGGGTTGAAAATTATTTGGTTTCATC
CATTGTCTCTTATTTCAGGACCAAGCAGCAAACTGCAGTAGTTTGTGAAGGATTCTAATATGGGGTTCAGGAATAGCCTCTCAACGCTAC
TAATTCAGATCTCTCCCAGAGAACTACTGGATTTCCTCATAATTGACAAACATGAGTGACCACCTCTTTGGGTGGCTACTGTTAGAAATG
GCTGTTGTCATGTTTTCTGGACTTTGCCAGCCAACAGATCCCTGCCAGGTTTTGGAAATACTTCTATTACCTCGCTGCTACTTTTCTGCA
GGGATAAAACTTTTGAGGTGGCCAGACCCAGAACATCCAAGGATTCCTGTTACAGTGCTACAGTATACACTGCTCATTTATCCTATTCTC
ATGTGCTTTCTTCTTTAGTAAGATTATTTTAAGAAAATAAGTGATATTTAAAGTCCAAAGAGGAATGATCACAGTTGTATAAGGGGTGTT
TTCCCACTTGAACTCTGATGTCAGTCGACTGTGGGTCAGAGCTACAACCATCTGTTTGGTTTGATGTTTTGGTGGTTTACTTACGGAGTG
GGGATAGTGTGAGACCTAATTCCCTGTGCAAATGTCTCTTATTCCAGAAATGTGCATTTTGTCATCTATAAGCAAGAAATATGGGCATAG
CAGCTCTTGGTTTAAAGTTTGCCATAACCTGTTCATGTTTGTTTTAAGCTCAGGTAAAGATAACCTCCTCTTTCTATGACTCCAGTTTCC
ATTCAGGTTATAGTATTATTCAATAGTTGATTTTCTTTTTAAGCTGGGCAATAAATTGATGTTTCCAGATGGTAACATGGGAGAGGGCAT
ATAGGATAAAGATGAGCAAATTCTACCCTAAAAATGTTCTAGTAGTTCACAGGAAGAAGATGAGGTTTAATAACTTTCAAGGTAATTCTA
GATTGACATTTTGAGGGGAAAATGGGCTCTTGTTCTAGTTGAAGTGAGCAGAGAAGGCTATAAATTAATATGTAACTTACAGCATTCCAG
AGGTTAAAAATAACTGATGCAGATGTACTTCTTCAGTGTGATTCTTCAGATCAAACTTTTACTTTTGGCATAGTTAATTTCAGAAAAATG
TGCTGTATGTGTGTGTGTATGAGGGTTGGTCTTGCTGATCCTTCAGTTAGCTCTAAATTCTGGCAACTCCTTGTAATTCCAATGTATTTG
ATACATGAACAATCATGTTGAATGCATTTGTGATCTGGGAGACTTCCTCGTCTTCCAGGGAAGGAAGGATGTGCAGCCCCTGAAGGCATG
AAACTCCCAGTGTGTACGGAGCCAGTGGAATATGGGATACCCATACCTTACCAGGCGCTGGTTCCTTCTGCTCACAATAACATCTGCCCA
AAGAGGGAGTGGGAAGAACGCTTAGCTCTTTCACTAGTATGGATTTGAGTTCATGGTCACTATTTTTACCCACCTGCCTTTGTTAAAAAT
CACTTTGAGTAGAATAGCACTGGAGGAACATATTTAGCACCTAATATTAATATTTAGTAGTCCATTGATAAATTTGCCAGCATATGTTCT
AGCCTCTGGGGGGAAACCAGGACCACTTTTGTCTGTGGCTTAAACAGTTCAGTTGCTATATCTGTTGGGTATGCCGGGGGTGGATGAGTG
TGGCATTCCGTGAAGAGGAAGGTGGTAAGTAAGGTTTCCCTTCTACTGCCTTCTTAAGTTGCAGGAGGGAGCTTTTCTCCTCCCCTCTGG
TTGGGAGCACTGAGGACAGTGAGGAGGGCTTTTACCTTGTTAATCCTTTCCTTATTTAGCTAGCTTTCCTTTTTGTCTAGGGCTTCCTCT
TGAGACCCTCTTCCATCCATTGGGCCTTTGAAAGGACTAATCAGACACACACACACACACACACACACACACACACACTCGCATACTCAT
GCACATTTTCCTTCATTTCCAGATCCTTTATTTCAGAGCAGCCCATTTTCCTCTGGATTCATTGATGAATACAAGTACCCACACCTTTGG
CCAGTAATGTCAGTTACCTGCTGCAGGTTCTGTGTATGAGGCCTTCATGAACGGTTACCTTCTCCATACACTAGGGAAGCATTTGTCAGA
CTCTGCAGACTGGGTTCTAGAGAGGCAGAGTCTTTAAGAGTATTCATTTCTTCTGGAAGGTGGAGCTTTACCCAAAGTGGAAGTTAGCCT
TGCTCAAAGATGTGTTTTGTGGTAGGTGGTAAAAATAAATAAATAAATAAATAATAAAAAAAGAAACATGTATTGGAGGTAATTTGACAC
TGCTGCTGGCAGTAGTTCTCTATTCACCATTTTAAAGCCCATTCAGGTTCTCTCTTCCTGAAAAGAACTGATTGCTGTGTTTACATGAAA
TGACATTGGAGTCAGATGGTCTGTTTTAAAGATTTCCATGACAGCCTCTTTTCCTGAGTTGGAGAGATTGGAGGTGGTCTATCCGTACGA
TGTGGAATCAAACGGTGGGTTTCTTAGTAGCTAAAGAAGCCATGTACTTCTAGTGTGTTTCTCAGAATATCAACTCATGTTCTTCAGATG
CTTTTCTTTTTTTAATGGTGAGGGAAAAGGTATAATTTGGGATTCCACAGTGCCTTGCATATAGTAGGCGCCCAGTAAATACTTGTTGAA
GCAAACCAAGTTTCCCAAGTCCTCATCTCTTATAGTGACCAAGACATCTTTCTCCTCTGAAGGGCTTGGCAGTTGTGGCTAAAAAATAAG
CAGTATCATTATTTGCTTGAAATCATATATACAGTTTGTATGAATTTCAGTATGTTGCCAAGACATGATTTTTTCTTATTGTATTTTCTG
TAAATATTTCTGGCACTGAACTGTAAAGTAAAGGCAAAGTGTAAATATGAAGGCGTGCCCGTGCCCCTTGCCTCCTGTGTTTCATCTTCG
TCGGTTAGGGAAGAAGGTCCAGAGGTTTGTTTGTATTTATGCCGATCCTTTGTCCAGAAGAAGCCCATGGAATATTGAATGTAATACATT

>52242_52242_3_MCM5-RALGAPB_MCM5_chr22_35799535_ENST00000216122_RALGAPB_chr20_37182510_ENST00000397042_length(amino acids)=597AA_BP=154
MSPLVCEVRKTRGAVMSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEME
DLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKLEERHEKLRSGMAQQIAYEIHLEQ
QSEEELQKRSFPDPVTDCKPPPPAQEFQTARLFLSHFGFLSLEALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFDTVFIFYM
KPGQKTNQEILKNVESSRTVQPHFLEFLLSLGWSVDVGRHPGWTGHVSTSWSINCCDDGEGSQQEEVISSEDIGASIFNGQKKVLYYADA
LTEIAFVVPSPVESLTDSLESNISDQDSDSNMDLMPGILKQPSLTLELFPNHTDNLNSSQRLSPSSRMRKLPQGRPVPPLGPETRVSVVW
VERYDDIENFPLSELMTEISTGVETTANSSTSLRSTTLEKEVPVIFIHPLNTGLFRIKIQGATGKFNMVIPLVDGMIVSRRALGFLVRQT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MCM5-RALGAPB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MCM5-RALGAPB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MCM5-RALGAPB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource