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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MCM6-RAB3GAP1 (FusionGDB2 ID:52248)

Fusion Gene Summary for MCM6-RAB3GAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: MCM6-RAB3GAP1
Fusion gene ID: 52248
HgeneTgene
Gene symbol

MCM6

RAB3GAP1

Gene ID

4175

22930

Gene nameminichromosome maintenance complex component 6RAB3 GTPase activating protein catalytic subunit 1
SynonymsMCG40308|Mis5|P105MCMP130|RAB3GAP|RAB3GAP130|WARBM1
Cytomap

2q21.3

2q21.3

Type of geneprotein-codingprotein-coding
DescriptionDNA replication licensing factor MCM6MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)minichromosome maintenance deficient (mis5, S. pombe) 6rab3 GTPase-activating protein catalytic subunitRAB3 GTPase activating protein subunit 1 (catalytic)RAB3 GTPase-activating protein 130 kDa subunitrab3-GAP p130
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264156, ENST00000492091, 
ENST00000487003, ENST00000425393, 
ENST00000264158, ENST00000442034, 
ENST00000539493, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 6 X 4=120
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MCM6 [Title/Abstract] AND RAB3GAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMCM6(136622583)-RAB3GAP1(135887565), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRAB3GAP1

GO:0043087

regulation of GTPase activity

10859313


check buttonFusion gene breakpoints across MCM6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAB3GAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-EK-A2R7-01AMCM6chr2

136622583

-RAB3GAP1chr2

135887565

+


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Fusion Gene ORF analysis for MCM6-RAB3GAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000264156ENST00000487003MCM6chr2

136622583

-RAB3GAP1chr2

135887565

+
5CDS-intronENST00000264156ENST00000425393MCM6chr2

136622583

-RAB3GAP1chr2

135887565

+
5UTR-3CDSENST00000492091ENST00000264158MCM6chr2

136622583

-RAB3GAP1chr2

135887565

+
5UTR-3CDSENST00000492091ENST00000442034MCM6chr2

136622583

-RAB3GAP1chr2

135887565

+
5UTR-3CDSENST00000492091ENST00000539493MCM6chr2

136622583

-RAB3GAP1chr2

135887565

+
5UTR-3UTRENST00000492091ENST00000487003MCM6chr2

136622583

-RAB3GAP1chr2

135887565

+
5UTR-intronENST00000492091ENST00000425393MCM6chr2

136622583

-RAB3GAP1chr2

135887565

+
In-frameENST00000264156ENST00000264158MCM6chr2

136622583

-RAB3GAP1chr2

135887565

+
In-frameENST00000264156ENST00000442034MCM6chr2

136622583

-RAB3GAP1chr2

135887565

+
In-frameENST00000264156ENST00000539493MCM6chr2

136622583

-RAB3GAP1chr2

135887565

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264156MCM6chr2136622583-ENST00000264158RAB3GAP1chr2135887565+503711396131111016
ENST00000264156MCM6chr2136622583-ENST00000539493RAB3GAP1chr2135887565+360311396131051014
ENST00000264156MCM6chr2136622583-ENST00000442034RAB3GAP1chr2135887565+434111396131321023

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264156ENST00000264158MCM6chr2136622583-RAB3GAP1chr2135887565+0.0001366360.9998634
ENST00000264156ENST00000539493MCM6chr2136622583-RAB3GAP1chr2135887565+0.0005934120.9994066
ENST00000264156ENST00000442034MCM6chr2136622583-RAB3GAP1chr2135887565+0.0001690640.99983096

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Fusion Genomic Features for MCM6-RAB3GAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MCM6-RAB3GAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:136622583/chr2:135887565)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCM6chr2:136622583chr2:135887565ENST00000264156-717346_553359822.0DomainNote=MCM
HgeneMCM6chr2:136622583chr2:135887565ENST00000264156-717528_531359822.0MotifNote=Arginine finger
HgeneMCM6chr2:136622583chr2:135887565ENST00000264156-717396_403359822.0Nucleotide bindingATP


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Fusion Gene Sequence for MCM6-RAB3GAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52248_52248_1_MCM6-RAB3GAP1_MCM6_chr2_136622583_ENST00000264156_RAB3GAP1_chr2_135887565_ENST00000264158_length(transcript)=5037nt_BP=1139nt
GGAAAAAAGCGACTTGTGGCGGTCGAGCGTGGCGCAGGCGAATCCTCGGCACTAAGCAAATATGGACCTCGCGGCGGCAGCGGAGCCGGG
CGCCGGCAGCCAGCACCTGGAGGTCCGCGACGAGGTGGCCGAGAAGTGCCAGAAACTGTTCCTGGACTTCTTGGAGGAGTTTCAGAGCAG
CGATGGAGAAATTAAATACTTGCAATTAGCAGAGGAACTGATTCGTCCTGAGAGAAACACATTGGTTGTGAGTTTTGTGGACCTGGAACA
ATTTAACCAGCAACTTTCCACCACCATTCAAGAGGAGTTCTATAGAGTTTACCCTTACCTGTGTCGGGCCTTGAAAACATTCGTCAAAGA
CCGTAAAGAGATCCCTCTTGCCAAGGATTTTTATGTTGCATTCCAAGACCTGCCTACCAGACACAAGATTCGAGAGCTCACCTCATCCAG
AATTGGTTTGCTCACTCGCATCAGTGGGCAGGTGGTGCGGACTCACCCAGTTCACCCAGAGCTTGTGAGCGGAACTTTTCTGTGCTTGGA
CTGTCAGACAGTGATCAGGGATGTAGAACAGCAGTTCAAATACACACAGCCAAACATCTGCCGAAATCCAGTTTGTGCCAACAGGAGGAG
ATTCTTACTGGATACAAATAAATCAAGATTTGTTGATTTTCAAAAGGTTCGTATTCAAGAGACCCAAGCTGAGCTTCCTCGAGGGAGTAT
CCCCCGCAGTTTAGAAGTAATTTTAAGGGCTGAAGCTGTGGAATCAGCTCAAGCTGGTGACAAGTGTGACTTTACAGGGACACTGATTGT
TGTGCCTGACGTCTCCAAGCTTAGCACACCAGGAGCACGTGCAGAAACTAATTCCCGTGTCAGTGGTGTTGATGGATATGAGACAGAAGG
CATTCGAGGACTCCGGGCCCTTGGTGTTAGGGACCTTTCTTATAGGCTGGTCTTTCTTGCCTGCTGTGTTGCGCCAACCAACCCAAGGTT
TGGGGGGAAAGAGCTCAGAGATGAGGAACAGACAGCTGAGAGCATTAAGAACCAAATGACTGTGAAAGAATGGGAGAAAGTGTTTGAGAT
GAGTCAAGATAAAAATCTATACCACAATCTTTGTACCAGCCTGTTCCCTACTATACATGGTGATTTTGTCACTGAATTTTTTAAAATTTG
CCGTCGAAAGGAGTCAACTGATGAGATTCTTGGACGATCTGCATTTGAGGAAGAAGGCAAAGAAACTGCTGATATAACTCATGCTTTGTC
AAAATTGACAGAGCCGGCATCAGTTCCAATTCATAAATTATCAGTTTCAAATATGGTACACACTGCAAAGAAGAAAATCCGAAAACACAG
AGGTGTAGAGGAGTCACCGCTAAATAATGATGTTCTTAATACTATTCTCCTGTTCTTATTCCCTGATGCTGTTTCTGAGAAACCATTAGA
TGGAACTACTTCAACAGATAATAATAATCCTCCATCAGAGAGTGAAGACTATAATCTCTACAATCAGTTCAAGTCTGCACCATCTGACAG
TTTAACATACAAACTGGCTTTGTGTCTCTGTATGATCAATTTTTACCATGGAGGGTTGAAAGGAGTGGCACACCTCTGGCAGGAATTTGT
TCTTGAAATGCGTTTCCGATGGGAAAACAACTTTCTGATTCCAGGATTAGCAAGTGGACCCCCAGATCTGAGGTGTTGTTTACTGCATCA
GAAACTACAGATGTTAAATTGTTGTATTGAAAGAAAGAAGGCACGTGATGAGGGGAAAAAGACAAGTGCTTCAGATGTCACTAATATATA
TCCAGGGGATGCTGGAAAAGCAGGAGACCAGTTGGTGCCAGATAATCTAAAAGAAACAGATAAGGAAAAGGGAGAGGTAGGAAAATCTTG
GGATTCCTGGAGTGACAGCGAAGAAGAATTTTTTGAATGCCTAAGTGATACTGAAGAACTTAAAGGAAATGGACAAGAGAGTGGCAAGAA
AGGAGGACCTAAGGAGATGGCAAATTTAAGGCCGGAAGGACGGCTCTATCAGCATGGGAAACTTACACTGCTGCATAATGGAGAACCTCT
CTACATTCCAGTAACCCAGGAACCAGCACCTATGACAGAAGATCTGCTAGAAGAGCAGTCTGAAGTTTTAGCTAAATTAGGTACATCGGC
AGAGGGGGCTCACCTTCGAGCACGCATGCAGAGTGCCTGTCTGCTCTCAGATATGGAGTCTTTTAAGGCAGCTAATCCAGGTTGCTCCCT
GGAAGATTTTGTGAGGTGGTATTCACCCCGGGATTATATTGAAGAGGAGGTGATTGATGAAAAGGGCAATGTGGTGCTGAAAGGAGAACT
GAGTGCCCGGATGAAGATTCCAAGCAATATGTGGGTAGAAGCCTGGGAAACAGCTAAGCCAATTCCTGCTAGAAGGCAAAGGAGACTCTT
TGATGATACACGGGAAGCAGAAAAGGTGCTGCACTATCTGGCAATCCAGAAACCTGCAGACCTTGCTCGGCACCTGTTACCTTGTGTGAT
TCATGCAGCTGTACTCAAGGTAAAGGAAGAAGAAAGTCTCGAAAACATTTCTTCAGTTAAGAAGATCATAAAGCAGATAATATCCCATTC
CAGTAAAGTTTTGCACTTCCCCAATCCAGAAGACAAGAAATTGGAAGAAATCATTCACCAGATTACTAATGTGGAAGCTCTCATTGCCAG
AGCTCGGTCACTAAAAGCCAAGTTTGGAACTGAGAAATGTGAACAGGAGGAGGAAAAGGAAGATCTTGAAAGGTTTGTGAGTTGCCTGCT
GGAGCAGCCTGAAGTGTTAGTCACCGGTGCAGGAAGAGGACATGCTGGCAGGATCATTCACAAGCTGTTTGTGAATGCCCAGAGGGCTGC
AGCTATGACTCCACCAGAGGAGGAATTGAAGAGAATGGGCTCCCCAGAGGAAAGAAGGCAGAACTCCGTGTCAGACTTCCCACCCCCTGC
TGGCCGGGAATTCATTTTGCGCACCACTGTGCCGCGCCCTGCTCCCTACTCCAAAGCTCTGCCTCAGCGGATGTACAGTGTTCTCACCAA
AGAGGACTTTAGACTTGCAGGTGCCTTTTCATCAGATACTTCCTTCTTCTGATTCTTCTAGCATTACTCGTTGGTGGCTTCAGAGACAGT
GCTGCCTCCTCCTGAGGGAGGGAAGGTACCAGGGAGAACCTGGGAGGTCCTGGAGAGGGCCCTGTCCAGTTGGGTGATCAGGAATCAAAC
CAGCATCGGAAAGACTTCCCAGCACCAAGCTTGAGCTGTGTCGTTTCGTGGAGGGGGCAGCGAGGATGGGCTTGAGCTGTTGAGAGATTT
CTGCCCTAGAGATGGCCTTTGTATATGGGGGGGTGGTGGGGGGACACAAACACATCAGACACTCCGTCCTCACACTGGCAGGACGGTGTT
CATCGCATTCTCTTCTGTGACCAGCCTCTAGGCTAGCGGCTGCATTCGTGGTCTGTGCAAACACTTCGTGGTTCTATATATCAGCAGCAA
GTGTGCAAAATAAAGGACCTGTTAACTCAGATTTCTGGATATTTTGGTGGTAGCTTCTAGTCCCAGAATCTGTGTTTTTAAAATACTACA
TGACATTCTGTCTATTCAATCACCTGGTGGTCATCTTTCTTGTACTAATTAACTGTTGATGAGCATTTTGGATATTCTAGGAGAAAGCCT
ATAATTTCACATAGTTTCTCTTTTTCATGTAACTGTAACCTAAATGTATTACTTCTGATAAAACTATATATCAAATGTCACTGCAAATTA
GTTTTATATCTGTCATGTGAGATTTGTCTTACTTATTTTTCTTTTGGTTGCCATGGAAGTTATGGCCCTGAAAATCGTCTCCCTCCCCTT
CTCTTGCTGTACAGCATGCGTTCTCTTTTTGTGGTTGCTGGCTGGGTACTGTATTTAATGAAGTAGAGAATAGCACTTGCAAAAATACAG
TCTTGGTACCTAGAGACTGTCATGCAGATAGTATAATTTGGTATATGTGCTAATGCATTGAGTAGAGGATTATTTTAACACACTATTTTG
CTTTTGTATTTTAGTTAAAATAATCGATGGGGATGTGTAGCCCCCCCGTGTGAGGATGACATCACCACATTTCTAGTTTCATGGAGCTCA
AGATGTCTTGTGTCTGTGTGGCTAGATGGCCTCTGCTTGGTAATCTTATTTTTAGGCCTAAAATTCCCACTTAAATCCAAAGTAAAAATG
GTTATACTGAAGCATAAACCTTGCCTGTGTAATTTTAAAAAATTAATAGAGCTGTGCAAACCCTGTTATTTTTGTAAAAAAAAAAAAAAA
TACATATCTATATATAATATGTGTGTGTGTGTGACATATGCACACGTCTCTGTGTATGTGAAGTAGGGGAGGCCCTGGGGGATGACCTCC
CAGCCTTTATGATGCTTTTCTCTATGCTGCTGGACTTCATTCTTACTGGTCCACGCAGATGCAGGCGGCCTGAGGCCAGTGCTGTACCAA
GTAGAAGACGGTTCCTAAGGACAGAGTTTGTCTGTTTTCTAACAAAGAAAAATTCTACAAAGGAGAGGTTGGGCGTTACAAAGGCATTGT
GAATCTAATAAAAGGAAAGTGTCGCTTTCTGTGGCGTTTTCTTTCATTTTCTCCCGCTGAGGCATTTCAGTCTAATTTCATGTGGTTTTG
TGCTGTCTCAGCTCTAATGTTTGCAGCCTGCTGAGCCTAACAAGGCAGTGGTCTCAAGAACATTCTTTGTGCCTTTTTAAAGTACTCCAT
TTTATTTTTATGATAGTTATGTATTTATTTCACAGATATATTTAAGTACCCACTTTGTGTCAGGTACAGTACAAGCAATGAAGATAAAAC
AGAAACCAAAACACACTCCCTTACAGGGAAAACTGACACCACGTTGCCACAAAATGTTGAGTATAGTCAACTCTGCTGTGTGGATCGGAG

>52248_52248_1_MCM6-RAB3GAP1_MCM6_chr2_136622583_ENST00000264156_RAB3GAP1_chr2_135887565_ENST00000264158_length(amino acids)=1016AA_BP=257
MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYL
CRALKTFVKDRKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNIC
RNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRV
SGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG
DFVTEFFKICRRKESTDEILGRSAFEEEGKETADITHALSKLTEPASVPIHKLSVSNMVHTAKKKIRKHRGVEESPLNNDVLNTILLFLF
PDAVSEKPLDGTTSTDNNNPPSESEDYNLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGP
PDLRCCLLHQKLQMLNCCIERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEEFFECLSDTEEL
KGNGQESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMES
FKAANPGCSLEDFVRWYSPRDYIEEEVIDEKGNVVLKGELSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVLHYLAIQKPAD
LARHLLPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVEALIARARSLKAKFGTEKCEQEEEKE
DLERFVSCLLEQPEVLVTGAGRGHAGRIIHKLFVNAQRAAAMTPPEEELKRMGSPEERRQNSVSDFPPPAGREFILRTTVPRPAPYSKAL

--------------------------------------------------------------
>52248_52248_2_MCM6-RAB3GAP1_MCM6_chr2_136622583_ENST00000264156_RAB3GAP1_chr2_135887565_ENST00000442034_length(transcript)=4341nt_BP=1139nt
GGAAAAAAGCGACTTGTGGCGGTCGAGCGTGGCGCAGGCGAATCCTCGGCACTAAGCAAATATGGACCTCGCGGCGGCAGCGGAGCCGGG
CGCCGGCAGCCAGCACCTGGAGGTCCGCGACGAGGTGGCCGAGAAGTGCCAGAAACTGTTCCTGGACTTCTTGGAGGAGTTTCAGAGCAG
CGATGGAGAAATTAAATACTTGCAATTAGCAGAGGAACTGATTCGTCCTGAGAGAAACACATTGGTTGTGAGTTTTGTGGACCTGGAACA
ATTTAACCAGCAACTTTCCACCACCATTCAAGAGGAGTTCTATAGAGTTTACCCTTACCTGTGTCGGGCCTTGAAAACATTCGTCAAAGA
CCGTAAAGAGATCCCTCTTGCCAAGGATTTTTATGTTGCATTCCAAGACCTGCCTACCAGACACAAGATTCGAGAGCTCACCTCATCCAG
AATTGGTTTGCTCACTCGCATCAGTGGGCAGGTGGTGCGGACTCACCCAGTTCACCCAGAGCTTGTGAGCGGAACTTTTCTGTGCTTGGA
CTGTCAGACAGTGATCAGGGATGTAGAACAGCAGTTCAAATACACACAGCCAAACATCTGCCGAAATCCAGTTTGTGCCAACAGGAGGAG
ATTCTTACTGGATACAAATAAATCAAGATTTGTTGATTTTCAAAAGGTTCGTATTCAAGAGACCCAAGCTGAGCTTCCTCGAGGGAGTAT
CCCCCGCAGTTTAGAAGTAATTTTAAGGGCTGAAGCTGTGGAATCAGCTCAAGCTGGTGACAAGTGTGACTTTACAGGGACACTGATTGT
TGTGCCTGACGTCTCCAAGCTTAGCACACCAGGAGCACGTGCAGAAACTAATTCCCGTGTCAGTGGTGTTGATGGATATGAGACAGAAGG
CATTCGAGGACTCCGGGCCCTTGGTGTTAGGGACCTTTCTTATAGGCTGGTCTTTCTTGCCTGCTGTGTTGCGCCAACCAACCCAAGGTT
TGGGGGGAAAGAGCTCAGAGATGAGGAACAGACAGCTGAGAGCATTAAGAACCAAATGACTGTGAAAGAATGGGAGAAAGTGTTTGAGAT
GAGTCAAGATAAAAATCTATACCACAATCTTTGTACCAGCCTGTTCCCTACTATACATGGTGATTTTGTCACTGAATTTTTTAAAATTTG
CCGTCGAAAGGAGTCAACTGATGAGATTCTTGGACGATCTGCATTTGAGGAAGAAGGCAAAGAAACTGCTGATATAACTCATGCTTTGTC
AAAATTGACAGAGCCGGCATCAGTTCCAATTCATAAATTATCAGTTTCAAATATGGTACACACTGCAAAGAAGAAAATCCGAAAACACAG
AGGTGTAGAGGAGTCACCGCTAAATAATGATGTTCTTAATACTATTCTCCTGTTCTTATTCCCTGATGCTGTTTCTGAGAAACCATTAGA
TGGAACTACTTCAACAGATAATAATAATCCTCCATCAGAGAGTGAAGACTATAATCTCTACAATCAGTTCAAGTCTGCACCATCTGACAG
TTTAACATACAAACTGGCTTTGTGTCTCTGTATGATCAATTTTTACCATGGAGGGTTGAAAGGAGTGGCACACCTCTGGCAGGAATTTGT
TCTTGAAATGCGTTTCCGATGGGAAAACAACTTTCTGATTCCAGGATTAGCAAGTGGACCCCCAGATCTGAGGTGTTGTTTACTGCATCA
GAAACTACAGATGTTAAATTGTTGTATTGAAAGAAAGAAGGCACGTGATGAGGGGAAAAAGACAAGTGCTTCAGATGTCACTAATATATA
TCCAGGGGATGCTGGAAAAGCAGGAGACCAGTTGGTGCCAGATAATCTAAAAGAAACAGATAAGGAAAAGGGAGAGGTAGGAAAATCTTG
GGATTCCTGGAGTGACAGCGAAGAAGAATTTTTTGAATGCCTAAGTGATACTGAAGAACTTAAAGGAAATGGACAAGAGAGTGGCAAGAA
AGGAGGACCTAAGGAGATGGCAAATTTAAGGCCGGAAGGACGGCTCTATCAGCATGGGAAACTTACACTGCTGCATAATGGAGAACCTCT
CTACATTCCAGTAACCCAGGAACCAGCACCTATGACAGAAGATCTGCTAGAAGAGCAGTCTGAAGTTTTAGCTAAATTAGGTACATCGGC
AGAGGGGGCTCACCTTCGAGCACGCATGCAGAGTGCCTGTCTGCTCTCAGATATGGAGTCTTTTAAGGCAGCTAATCCAGGTTGCTCCCT
GGAAGATTTTGTGAGGTGGTATTCACCCCGGGATTATATTGAAGAGGAGGTGATTGATGAAAAGGGCAATGTGGTGCTGAAAGGAGAACT
GAGTGCCCGGATGAAGATTCCAAGCAATATGTGGGTAGAAGCCTGGGAAACAGCTAAGCCAATTCCTGCTAGAAGGCAAAGGAGACTCTT
TGATGATACACGGGAAGCAGAAAAGGTGCTGCACTATCTGGCAATCCAGAAACCTGCAGACCTTGCTCGGCACCTGTTACCTTGTGTGAT
TCATGCAGCTGTACTCAAGGTAAAGGAAGAAGAAAGTCTCGAAAACATTTCTTCAGTTAAGAAGATCATAAAGCAGATAATATCCCATTC
CAGTAAAGTTTTGCACTTCCCCAATCCAGAAGACAAGAAATTGGAAGAAATCATTCACCAGATTACTAATGTGGAAGCTCTCATTGCCAG
AGCTCGGTCACTAAAAGCCAAGTTTGGAACTGAGAAATGTGAACAGGAGGAGGAAAAGGAAGATCTTGAAAGGTTTGTGAGTTGCCTGCT
GGAGCAGCCTGAAGTGTTAGTCACCGGTGCAGGAAGAGGACATGCTGGCAGGATCATTCACAAGCTGTTTGTGAATGCCCAGAGGCTGAC
TGAATCTTCTGATGAGGCTGCAGCTATGACTCCACCAGAGGAGGAATTGAAGAGAATGGGCTCCCCAGAGGAAAGAAGGCAGAACTCCGT
GTCAGACTTCCCACCCCCTGCTGGCCGGGAATTCATTTTGCGCACCACTGTGCCGCGCCCTGCTCCCTACTCCAAAGCTCTGCCTCAGCG
GATGTACAGTGTTCTCACCAAAGAGGACTTTAGACTTGCAGGTGCCTTTTCATCAGATACTTCCTTCTTCTGATTCTTCTAGCATTACTC
GTTGGTGGCTTCAGAGACAGTGCTGCCTCCTCCTGAGGGAGGGAAGGTACCAGGGAGAACCTGGGAGGTCCTGGAGAGGGCCCTGTCCAG
TTGGGTGATCAGGAATCAAACCAGCATCGGAAAGACTTCCCAGCACCAAGCTTGAGCTGTGTCGTTTCGTGGAGGGGGCAGCGAGGATGG
GCTTGAGCTGTTGAGAGATTTCTGCCCTAGAGATGGCCTTTGTATATGGGGGGGTGGTGGGGGGACACAAACACATCAGACACTCCGTCC
TCACACTGGCAGGACGGTGTTCATCGCATTCTCTTCTGTGACCAGCCTCTAGGCTAGCGGCTGCATTCGTGGTCTGTGCAAACACTTCGT
GGTTCTATATATCAGCAGCAAGTGTGCAAAATAAAGGACCTGTTAACTCAGATTTCTGGATATTTTGGTGGTAGCTTCTAGTCCCAGAAT
CTGTGTTTTTAAAATACTACATGACATTCTGTCTATTCAATCACCTGGTGGTCATCTTTCTTGTACTAATTAACTGTTGATGAGCATTTT
GGATATTCTAGGAGAAAGCCTATAATTTCACATAGTTTCTCTTTTTCATGTAACTGTAACCTAAATGTATTACTTCTGATAAAACTATAT
ATCAAATGTCACTGCAAATTAGTTTTATATCTGTCATGTGAGATTTGTCTTACTTATTTTTCTTTTGGTTGCCATGGAAGTTATGGCCCT
GAAAATCGTCTCCCTCCCCTTCTCTTGCTGTACAGCATGCGTTCTCTTTTTGTGGTTGCTGGCTGGGTACTGTATTTAATGAAGTAGAGA
ATAGCACTTGCAAAAATACAGTCTTGGTACCTAGAGACTGTCATGCAGATAGTATAATTTGGTATATGTGCTAATGCATTGAGTAGAGGA
TTATTTTAACACACTATTTTGCTTTTGTATTTTAGTTAAAATAATCGATGGGGATGTGTAGCCCCCCCGTGTGAGGATGACATCACCACA
TTTCTAGTTTCATGGAGCTCAAGATGTCTTGTGTCTGTGTGGCTAGATGGCCTCTGCTTGGTAATCTTATTTTTAGGCCTAAAATTCCCA
CTTAAATCCAAAGTAAAAATGGTTATACTGAAGCATAAACCTTGCCTGTGTAATTTTAAAAAATTAATAGAGCTGTGCAAACCCTGTTAT

>52248_52248_2_MCM6-RAB3GAP1_MCM6_chr2_136622583_ENST00000264156_RAB3GAP1_chr2_135887565_ENST00000442034_length(amino acids)=1023AA_BP=257
MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYL
CRALKTFVKDRKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNIC
RNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRV
SGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG
DFVTEFFKICRRKESTDEILGRSAFEEEGKETADITHALSKLTEPASVPIHKLSVSNMVHTAKKKIRKHRGVEESPLNNDVLNTILLFLF
PDAVSEKPLDGTTSTDNNNPPSESEDYNLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGP
PDLRCCLLHQKLQMLNCCIERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEEFFECLSDTEEL
KGNGQESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMES
FKAANPGCSLEDFVRWYSPRDYIEEEVIDEKGNVVLKGELSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVLHYLAIQKPAD
LARHLLPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVEALIARARSLKAKFGTEKCEQEEEKE
DLERFVSCLLEQPEVLVTGAGRGHAGRIIHKLFVNAQRLTESSDEAAAMTPPEEELKRMGSPEERRQNSVSDFPPPAGREFILRTTVPRP

--------------------------------------------------------------
>52248_52248_3_MCM6-RAB3GAP1_MCM6_chr2_136622583_ENST00000264156_RAB3GAP1_chr2_135887565_ENST00000539493_length(transcript)=3603nt_BP=1139nt
GGAAAAAAGCGACTTGTGGCGGTCGAGCGTGGCGCAGGCGAATCCTCGGCACTAAGCAAATATGGACCTCGCGGCGGCAGCGGAGCCGGG
CGCCGGCAGCCAGCACCTGGAGGTCCGCGACGAGGTGGCCGAGAAGTGCCAGAAACTGTTCCTGGACTTCTTGGAGGAGTTTCAGAGCAG
CGATGGAGAAATTAAATACTTGCAATTAGCAGAGGAACTGATTCGTCCTGAGAGAAACACATTGGTTGTGAGTTTTGTGGACCTGGAACA
ATTTAACCAGCAACTTTCCACCACCATTCAAGAGGAGTTCTATAGAGTTTACCCTTACCTGTGTCGGGCCTTGAAAACATTCGTCAAAGA
CCGTAAAGAGATCCCTCTTGCCAAGGATTTTTATGTTGCATTCCAAGACCTGCCTACCAGACACAAGATTCGAGAGCTCACCTCATCCAG
AATTGGTTTGCTCACTCGCATCAGTGGGCAGGTGGTGCGGACTCACCCAGTTCACCCAGAGCTTGTGAGCGGAACTTTTCTGTGCTTGGA
CTGTCAGACAGTGATCAGGGATGTAGAACAGCAGTTCAAATACACACAGCCAAACATCTGCCGAAATCCAGTTTGTGCCAACAGGAGGAG
ATTCTTACTGGATACAAATAAATCAAGATTTGTTGATTTTCAAAAGGTTCGTATTCAAGAGACCCAAGCTGAGCTTCCTCGAGGGAGTAT
CCCCCGCAGTTTAGAAGTAATTTTAAGGGCTGAAGCTGTGGAATCAGCTCAAGCTGGTGACAAGTGTGACTTTACAGGGACACTGATTGT
TGTGCCTGACGTCTCCAAGCTTAGCACACCAGGAGCACGTGCAGAAACTAATTCCCGTGTCAGTGGTGTTGATGGATATGAGACAGAAGG
CATTCGAGGACTCCGGGCCCTTGGTGTTAGGGACCTTTCTTATAGGCTGGTCTTTCTTGCCTGCTGTGTTGCGCCAACCAACCCAAGGTT
TGGGGGGAAAGAGCTCAGAGATGAGGAACAGACAGCTGAGAGCATTAAGAACCAAATGACTGTGAAAGAATGGGAGAAAGTGTTTGAGAT
GAGTCAAGATAAAAATCTATACCACAATCTTTGTACCAGCCTGTTCCCTACTATACATGGTGATTTTGTCACTGAATTTTTTAAAATTTG
CCGTCGAAAGGAGTCAACTGATGAGATTCTTGGACGATCTGCATTTGAGGAAGAAGGCAAAGAAACTGCTGATATAACTCATGCTTTGTC
AAAATTGACAGAGCCGGCATCAGTTCCAATTCATAAATTATCAGTTTCAAATATGGTACACACTGCAAAGAAGAAAATCCGAAAACACAG
AGGTGTAGAGGAGTCACCGCTAAATAATGATGTTCTTAATACTATTCTCCTGTTCTTATTCCCTGATGCTGTTTCTGAGAAACCATTAGA
TGGAACTACTTCAACAGATAATAATAATCCTCCATCAGAGAGTGAAGACTATAATCTCTACAATCAGTTCAAGTCTGCACCATCTGACAG
TTTAACATACAAACTGGCTTTGTGTCTCTGTATGATCAATTTTTACCATGGAGGGTTGAAAGGAGTGGCACACCTCTGGCAGGAATTTGT
TCTTGAAATGCGTTTCCGATGGGAAAACAACTTTCTGATTCCAGGATTAGCAAGTGGACCCCCAGATCTGAGGTGTTGTTTACTGCATCA
GAAACTACAGATGTTAAATTGTTGTATTGAAAGAAAGAAGGCACGTGATGAGGGGAAAAAGACAAGTGCTTCAGATGTCACTAATATATA
TCCAGGGGATGCTGGAAAAGCAGGAGACCAGTTGGTGCCAGATAATCTAAAAGAAACAGATAAGGAAAAGGGAGAGGTAGGAAAATCTTG
GGATTCCTGGAGTGACAGCGAAGAAGAATTTTTTGAATGCCTAAGTGATACTGAAGAACTTAAAGGAAATGGACAAGAGAGTGGCAAGAA
AGGAGGACCTAAGGAGATGGCAAATTTAAGGCCGGAAGGACGGCTCTATCAGCATGGGAAACTTACACTGCTGCATAATGGAGAACCTCT
CTACATTCCAGTAACCCAGGAACCAGCACCTATGACAGAAGATCTGCTAGAAGAGCAGTCTGAAGTTTTAGCTAAATTAGGTACATCGGC
AGAGGGGGCTCACCTTCGAGCACGCATGCAGAGTGCCTGTCTGCTCTCAGATATGGAGTCTTTTAAGGCAGCTAATCCAGGTTGCTCCCT
GGAAGATTTTGTGAGGTGGTATTCACCCCGGGATTATATTGAAGAGGAGGTGATTGATGAAAAGGGCAATGTGGTGCTGAAAGGAGAACT
GAGTGCCCGGATGAAGATTCCAAGCAATATGTGGGTAGAAGCCTGGGAAACAGCTAAGCCAATTCCTGCTAGAAGGCAAAGGAGACTCTT
TGATGATACACGGGAAGCAGAAAAGGTGCTGCACTATCTGGCAATCCAGAAACCTGCAGACCTTGCTCGGCACCTGTTACCTTGTGTGAT
TCATGCAGCTGTACTCAAGGTAAAGGAAGAAGAAAGTCTCGAAAACATTTCTTCAGTTAAGAAGATCATAAAGCAGATAATATCCCATTC
CAGTAAAGTTTTGCACTTCCCCAATCCAGAAGACAAGAAATTGGAAGAAATCATTCACCAGATTACTAATGTGGAAGCTCTCATTGCCAG
AGCTCGGTCACTAAAAGCCAAGTTTGGAACTGAGAAATGTGAACAGGAGGAGGAAAAGGAAGATCTTGAAAGGTTTGTGAGTTGCCTGCT
GGAGCAGCCTGAAGTGTTAGTCACCGGTGCAGGAAGAGGACATGCTGGCAGGATCATTCACAAGCTGTTTGTGAATGCCCAGAGGGCTGC
AGCTATGACTCCACCAGAGGAGGAATTGAAGAGAATGGGCTCCCCAGAGGAAAGAAGGCAGAACTCCGTGTCAGACTTCCCACCCCCTGC
TGGCCGGGAATTCATTTTGCGCACCACTGTGCCGCGCCCTGCTCCCTACTCCAAAGCTCTGCCTCAGCGGATGTACAGTGTTCTCACCAA
AGAGGACTTTAGACTTGCAGTTAAAATAATCGATGGGGATGTGTAGCCCCCCCGTGTGAGGATGACATCACCACATTTCTAGTTTCATGG
AGCTCAAGATGTCTTGTGTCTGTGTGGCTAGATGGCCTCTGCTTGCTCCCCAGGTGTGTCCTGGTAGACAACTGCTCCCAGGAGCTGGCA
TAGAAGCAAACCTGCAGGAAAAGCCAACCCACTCCAGGTGTGTGGAAGCTGCTGGCAGGAACCCAGCAAGGATCCAGCTGGGTTGTAATG
GAAACAATGCAACCAACAATCCTTGAGCGAGCCGGGATAGATGTGGCCTCATCACTGAAGATTTCATCTGAGACCTCTGCAAATATCCAA
ATTGTATATGCTCTTAGAGCAGATCATTTTCTCACAGGTTGTCTAACCAAAGGAAAGGAAATCAGCATATCAAAGAGATATCTGCACTCC
CATGTTGATTGCAGCACTGTTCACAACAGCCAAGATGTGGAATCAACCAGAGTGTCCATTGGCAGATGAATGGATTAAAAATGTGGTGCA

>52248_52248_3_MCM6-RAB3GAP1_MCM6_chr2_136622583_ENST00000264156_RAB3GAP1_chr2_135887565_ENST00000539493_length(amino acids)=1014AA_BP=257
MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYL
CRALKTFVKDRKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNIC
RNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRV
SGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG
DFVTEFFKICRRKESTDEILGRSAFEEEGKETADITHALSKLTEPASVPIHKLSVSNMVHTAKKKIRKHRGVEESPLNNDVLNTILLFLF
PDAVSEKPLDGTTSTDNNNPPSESEDYNLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGP
PDLRCCLLHQKLQMLNCCIERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEEFFECLSDTEEL
KGNGQESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMES
FKAANPGCSLEDFVRWYSPRDYIEEEVIDEKGNVVLKGELSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVLHYLAIQKPAD
LARHLLPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVEALIARARSLKAKFGTEKCEQEEEKE
DLERFVSCLLEQPEVLVTGAGRGHAGRIIHKLFVNAQRAAAMTPPEEELKRMGSPEERRQNSVSDFPPPAGREFILRTTVPRPAPYSKAL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MCM6-RAB3GAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MCM6-RAB3GAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MCM6-RAB3GAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource