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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AP2A2-EPS8L2 (FusionGDB2 ID:5226)

Fusion Gene Summary for AP2A2-EPS8L2

Fusion gene summary

Fusion gene information	Fusion gene name: AP2A2-EPS8L2
	Fusion gene ID: 5226
		Hgene	Tgene
	Gene symbol	AP2A2	EPS8L2
	Gene ID	161	64787
	Gene name	adaptor related protein complex 2 subunit alpha 2	EPS8 like 2
	Synonyms	ADTAB\|CLAPA2\|HIP-9\|HIP9\|HYPJ	DFNB106\|EPS8R2
	Cytomap	11p15.5	11p15.5
	Type of gene	protein-coding	protein-coding
	Description	AP-2 complex subunit alpha-2100 kDa coated vesicle protein Cadapter-related protein complex 2 subunit alpha-2adaptin, alpha Badaptor related protein complex 2 alpha 2 subunitalpha-adaptin C; Huntingtin interacting protein Jalpha2-adaptinclathrin as	epidermal growth factor receptor kinase substrate 8-like protein 2EPS8-related protein 2epidermal growth factor receptor pathway substrate 8-related protein 2
	Modification date	20200313	20200313
	UniProtAcc	O94973	Q9H6S3
	Ensembl transtripts involved in fusion gene	ENST00000332231, ENST00000448903, ENST00000525891, ENST00000534328,	ENST00000534449, ENST00000318562, ENST00000526198, ENST00000530636, ENST00000533256,
Fusion gene scores	* DoF score	13 X 10 X 12=1560	9 X 7 X 8=504
	# samples	22	15
	** MAII score	log2(22/1560*10)=-2.82597060022495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/504*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AP2A2 [Title/Abstract] AND EPS8L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AP2A2(994245)-EPS8L2(720062), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AP2A2	GO:0072583	clathrin-dependent endocytosis	23676497
Tgene	EPS8L2	GO:0007266	Rho protein signal transduction	14565974
Tgene	EPS8L2	GO:0035023	regulation of Rho protein signal transduction	14565974

Fusion gene breakpoints across AP2A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EPS8L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-21-1071-01A	AP2A2	chr11	994245	-	EPS8L2	chr11	720062	+
ChimerDB4	LUSC	TCGA-21-1071-01A	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
ChimerDB4	LUSC	TCGA-21-1071	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+

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Fusion Gene ORF analysis for AP2A2-EPS8L2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000332231	ENST00000534449	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
5CDS-intron	ENST00000448903	ENST00000534449	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
In-frame	ENST00000332231	ENST00000318562	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
In-frame	ENST00000332231	ENST00000526198	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
In-frame	ENST00000332231	ENST00000530636	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
In-frame	ENST00000332231	ENST00000533256	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
In-frame	ENST00000448903	ENST00000318562	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
In-frame	ENST00000448903	ENST00000526198	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
In-frame	ENST00000448903	ENST00000530636	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
In-frame	ENST00000448903	ENST00000533256	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
intron-3CDS	ENST00000525891	ENST00000318562	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
intron-3CDS	ENST00000525891	ENST00000526198	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
intron-3CDS	ENST00000525891	ENST00000530636	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
intron-3CDS	ENST00000525891	ENST00000533256	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
intron-3CDS	ENST00000534328	ENST00000318562	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
intron-3CDS	ENST00000534328	ENST00000526198	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
intron-3CDS	ENST00000534328	ENST00000530636	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
intron-3CDS	ENST00000534328	ENST00000533256	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
intron-intron	ENST00000525891	ENST00000534449	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+
intron-intron	ENST00000534328	ENST00000534449	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000332231	AP2A2	chr11	994245	+	ENST00000318562	EPS8L2	chr11	720062	+	4829	2100	141	4082	1313
ENST00000332231	AP2A2	chr11	994245	+	ENST00000533256	EPS8L2	chr11	720062	+	4826	2100	141	4082	1313
ENST00000332231	AP2A2	chr11	994245	+	ENST00000530636	EPS8L2	chr11	720062	+	4153	2100	141	4082	1313
ENST00000332231	AP2A2	chr11	994245	+	ENST00000526198	EPS8L2	chr11	720062	+	4184	2100	141	4130	1329
ENST00000448903	AP2A2	chr11	994245	+	ENST00000318562	EPS8L2	chr11	720062	+	4826	2097	141	4079	1312
ENST00000448903	AP2A2	chr11	994245	+	ENST00000533256	EPS8L2	chr11	720062	+	4823	2097	141	4079	1312
ENST00000448903	AP2A2	chr11	994245	+	ENST00000530636	EPS8L2	chr11	720062	+	4150	2097	141	4079	1312
ENST00000448903	AP2A2	chr11	994245	+	ENST00000526198	EPS8L2	chr11	720062	+	4181	2097	141	4127	1328

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000332231	ENST00000318562	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+	0.003650809	0.9963492
ENST00000332231	ENST00000533256	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+	0.003642894	0.996357
ENST00000332231	ENST00000530636	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+	0.00572386	0.9942761
ENST00000332231	ENST00000526198	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+	0.005512554	0.99448746
ENST00000448903	ENST00000318562	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+	0.003624168	0.99637586
ENST00000448903	ENST00000533256	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+	0.003616297	0.99638367
ENST00000448903	ENST00000530636	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+	0.005676464	0.9943236
ENST00000448903	ENST00000526198	AP2A2	chr11	994245	+	EPS8L2	chr11	720062	+	0.005467582	0.99453235

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Fusion Genomic Features for AP2A2-EPS8L2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AP2A2	chr11	994245	+	EPS8L2	chr11	720061	+	5.32E-11	1
AP2A2	chr11	994245	+	EPS8L2	chr11	720061	+	5.32E-11	1
AP2A2	chr11	994245	+	EPS8L2	chr11	720061	+	5.32E-11	1
AP2A2	chr11	994245	+	EPS8L2	chr11	720061	+	5.32E-11	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AP2A2-EPS8L2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:994245/chr11:720062)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AP2A2 O94973	EPS8L2 Q9H6S3
FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269\|PubMed:12960147, ECO:0000269\|PubMed:14745134, ECO:0000269\|PubMed:15473838, ECO:0000269\|PubMed:19033387, ECO:0000269\|PubMed:23676497}.	FUNCTION: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250\|UniProtKB:Q99K30, ECO:0000269\|PubMed:14565974}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AP2A2

chr11:994245

chr11:720062

ENST00000332231

11_12

653

941.0

Region

Phosphatidylinositol 3%2C4%2C5-trisphosphate binding

Hgene

AP2A2

chr11:994245

chr11:720062

ENST00000332231

57_61

653

941.0

Region

Phosphatidylinositol 3%2C4%2C5-trisphosphate binding

Hgene

AP2A2

chr11:994245

chr11:720062

ENST00000332231

5_80

653

941.0

Region

Note=Lipid-binding

Hgene

AP2A2

chr11:994245

chr11:720062

ENST00000448903

11_12

652

940.0

Region

Phosphatidylinositol 3%2C4%2C5-trisphosphate binding

Hgene

AP2A2

chr11:994245

chr11:720062

ENST00000448903

57_61

652

940.0

Region

Phosphatidylinositol 3%2C4%2C5-trisphosphate binding

Hgene

AP2A2

chr11:994245

chr11:720062

ENST00000448903

5_80

652

940.0

Region

Note=Lipid-binding

Tgene

EPS8L2

chr11:994245

chr11:720062

ENST00000318562

492_551

716.0

Domain

SH3

Tgene

EPS8L2

chr11:994245

chr11:720062

ENST00000530636

492_551

716.0

Domain

SH3

Tgene

EPS8L2

chr11:994245

chr11:720062

ENST00000533256

492_551

716.0

Domain

SH3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EPS8L2

chr11:994245

chr11:720062

ENST00000318562

46_202

716.0

Domain

PID

Tgene

EPS8L2

chr11:994245

chr11:720062

ENST00000530636

46_202

716.0

Domain

PID

Tgene

EPS8L2

chr11:994245

chr11:720062

ENST00000533256

46_202

716.0

Domain

PID

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Fusion Gene Sequence for AP2A2-EPS8L2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5226_5226_1_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000318562_length(transcript)=4829nt_BP=2100nt
CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC
GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG
GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA
TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC
TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC
TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC
TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC
GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG
CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA
ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG
GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGAAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGC
CTGGAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCC
ATCAGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACC
AACCTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTC
ATCAACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCA
CAGATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAG
AAGTACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTAC
CGAGTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCAC
GAGAACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTC
CACCTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCG
GAGGTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTAC
CTGCGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTG
GCAAAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCT
GAGCCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATC
CGGAAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGAC
ATCGAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTG
CTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAG
GACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGG
CAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGC
CCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAG
ACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAG
CGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATC
GACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCAC
TTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGAT
GCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAG
TGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGG
GAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACT
TCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAG
TACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGC
CGGCAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGC
GCCCCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAG
CTCATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAG
CGCAGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGG
ATCGTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTC
CGCGTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCAT
TCCATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCTTGGGCTGGGGCCTGCGGAGGGGAAGCCCACCCACAATGCATGGAG
TATTATTTTTATATGTGTATGTATTTTGTATCAAGGACACGGAGGGGGTGTGGTGCTGGCTAGAGGTCCCTGCCCCTGTCTGGAGGCACA
ACGCCCATCCTTAGGCCAAACAGTACCCAAGGCCTCAGCCCACACCAAGACTAATCTCAGCCAAACCTGCTGCTTGGTGGTGCCAGCCCC
TTGTCCACCTTCTCTTGAGGCCACAGAACTCCCTGGGGCTGGGGCCTCTTTCTCTGGCCTCCCCTGTGCACCTGGGGGGTCCTGGCCCCT
GTGATGCTCCCCCATCCCCACCCACTTCTACATCCATCCACACCCCAGGGTGAGCTGGAGCTCCAGGCTGGCCAGGCTGAACCTCGCACA
CACGCAGAGTTCTGCTCCCTGAGGGGGGCCCGGGAGGGGCTCCAGCAGGAGGCCGTGGGTGCCATTCGGGGGAAAGTGGGGGAACGACAC
ACACTTCACCTGCAAGGGCCGACAACGCAGGGGACACCGTGCCGGCTTCAGACACTCCCAGCGCCCACTCTTACAGGCCCAGGACTGGAG
CTTTCTCTGGCCAAGTTTCAGGCCAATGATCCCCGCATGGTGTTGGGGGTGCTGGTGTGTCTTGGTGCCTGGACTTGAGTCTCACCCTAC

>5226_5226_1_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000318562_length(amino acids)=1313AA_BP=646
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP
PEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSE
FSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLI
RIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRAL
LLSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLED
TKRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQR
SQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQH
RGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVL
TLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLW
ESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPH
THRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPT
HKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLN

--------------------------------------------------------------
>5226_5226_2_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000526198_length(transcript)=4184nt_BP=2100nt
CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC
GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG
GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA
TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC
TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC
TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC
TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC
GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG
CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA
ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG
GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGAAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGC
CTGGAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCC
ATCAGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACC
AACCTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTC
ATCAACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCA
CAGATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAG
AAGTACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTAC
CGAGTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCAC
GAGAACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTC
CACCTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCG
GAGGTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTAC
CTGCGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTG
GCAAAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCT
GAGCCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATC
CGGAAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGAC
ATCGAGTCACAGAGTGCCCAGACCCCGGGTGCGAGTCGTGTCCGCGCGATGTACCCGCAGGAGGAGCTGGAAGACTTCCCGCTGCCCACG
GTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTGCTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGAT
GTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAGGACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAG
ATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGGCAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCC
TTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGCCCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAG
TCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAGACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTT
GTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAGCGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAG
GGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATCGACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCA
AAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCACTTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGT
GGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGATGCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATG
TCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAGTGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTC
CACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGGGAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGT
CCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACTTCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGC
TCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAGTACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAAC
GAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGCCGGCAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGG
TACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGCGCCCCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCC
AGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAGCTCATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGG
AAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAGCGCAGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGT
CCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGGATCGTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTC
TCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTCCGCGTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAG
AAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCATTCCATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTG

>5226_5226_2_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000526198_length(amino acids)=1329AA_BP=646
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP
PEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSE
FSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLI
RIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRAL
LLSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLED
TKRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQSAQTPGASRVRAM
YPQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQ
SILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQR
KKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDA
VDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTS
EPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGA
PFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRI

--------------------------------------------------------------
>5226_5226_3_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000530636_length(transcript)=4153nt_BP=2100nt
CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC
GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG
GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA
TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC
TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC
TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC
TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC
GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG
CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA
ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG
GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGAAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGC
CTGGAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCC
ATCAGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACC
AACCTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTC
ATCAACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCA
CAGATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAG
AAGTACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTAC
CGAGTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCAC
GAGAACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTC
CACCTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCG
GAGGTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTAC
CTGCGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTG
GCAAAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCT
GAGCCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATC
CGGAAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGAC
ATCGAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTG
CTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAG
GACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGG
CAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGC
CCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAG
ACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAG
CGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATC
GACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCAC
TTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGAT
GCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAG
TGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGG
GAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACT
TCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAG
TACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGC
CGGCAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGC
GCCCCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAG
CTCATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAG
CGCAGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGG
ATCGTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTC
CGCGTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCAT
TCCATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCTTGGGCTGGGGCCTGCGGAGGGGAAGCCCACCCACAATGCATGGAG

>5226_5226_3_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000530636_length(amino acids)=1313AA_BP=646
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP
PEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSE
FSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLI
RIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRAL
LLSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLED
TKRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQR
SQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQH
RGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVL
TLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLW
ESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPH
THRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPT
HKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLN

--------------------------------------------------------------
>5226_5226_4_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000533256_length(transcript)=4826nt_BP=2100nt
CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC
GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG
GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA
TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC
TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC
TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC
TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC
GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG
CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA
ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG
GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGAAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGC
CTGGAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCC
ATCAGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACC
AACCTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTC
ATCAACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCA
CAGATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAG
AAGTACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTAC
CGAGTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCAC
GAGAACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTC
CACCTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCG
GAGGTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTAC
CTGCGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTG
GCAAAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCT
GAGCCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATC
CGGAAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGAC
ATCGAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTG
CTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAG
GACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGG
CAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGC
CCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAG
ACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAG
CGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATC
GACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCAC
TTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGAT
GCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAG
TGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGG
GAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACT
TCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAG
TACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGC
CGGCAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGC
GCCCCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAG
CTCATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAG
CGCAGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGG
ATCGTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTC
CGCGTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCAT
TCCATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCTTGGGCTGGGGCCTGCGGAGGGGAAGCCCACCCACAATGCATGGAG
TATTATTTTTATATGTGTATGTATTTTGTATCAAGGACACGGAGGGGGTGTGGTGCTGGCTAGAGGTCCCTGCCCCTGTCTGGAGGCACA
ACGCCCATCCTTAGGCCAAACAGTACCCAAGGCCTCAGCCCACACCAAGACTAATCTCAGCCAAACCTGCTGCTTGGTGGTGCCAGCCCC
TTGTCCACCTTCTCTTGAGGCCACAGAACTCCCTGGGGCTGGGGCCTCTTTCTCTGGCCTCCCCTGTGCACCTGGGGGGTCCTGGCCCCT
GTGATGCTCCCCCATCCCCACCCACTTCTACATCCATCCACACCCCAGGGTGAGCTGGAGCTCCAGGCTGGCCAGGCTGAACCTCGCACA
CACGCAGAGTTCTGCTCCCTGAGGGGGGCCCGGGAGGGGCTCCAGCAGGAGGCCGTGGGTGCCATTCGGGGGAAAGTGGGGGAACGACAC
ACACTTCACCTGCAAGGGCCGACAACGCAGGGGACACCGTGCCGGCTTCAGACACTCCCAGCGCCCACTCTTACAGGCCCAGGACTGGAG
CTTTCTCTGGCCAAGTTTCAGGCCAATGATCCCCGCATGGTGTTGGGGGTGCTGGTGTGTCTTGGTGCCTGGACTTGAGTCTCACCCTAC

>5226_5226_4_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000533256_length(amino acids)=1313AA_BP=646
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP
PEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSE
FSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLI
RIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRAL
LLSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLED
TKRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQR
SQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQH
RGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVL
TLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLW
ESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPH
THRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPT
HKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLN

--------------------------------------------------------------
>5226_5226_5_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000318562_length(transcript)=4826nt_BP=2097nt
CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC
GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG
GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA
TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC
TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC
TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC
TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC
GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG
CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA
ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG
GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGCCTG
GAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCCATC
AGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACCAAC
CTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTCATC
AACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCACAG
ATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAGAAG
TACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTACCGA
GTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCACGAG
AACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTCCAC
CTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCGGAG
GTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTACCTG
CGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTGGCA
AAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCTGAG
CCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATCCGG
AAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGACATC
GAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTGCTG
CTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAGGAC
ATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGGCAG
TCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGCCCG
CAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAGACG
CAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAGCGG
AAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATCGAC
TGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCACTTC
CTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGATGCC
GTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAGTGG
CCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGGGAG
GTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACTTCA
GAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAGTAC
GTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGCCGG
CAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGCGCC
CCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAGCTC
ATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAGCGC
AGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGGATC
GTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTCCGC
GTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCATTCC
ATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCTTGGGCTGGGGCCTGCGGAGGGGAAGCCCACCCACAATGCATGGAGTAT
TATTTTTATATGTGTATGTATTTTGTATCAAGGACACGGAGGGGGTGTGGTGCTGGCTAGAGGTCCCTGCCCCTGTCTGGAGGCACAACG
CCCATCCTTAGGCCAAACAGTACCCAAGGCCTCAGCCCACACCAAGACTAATCTCAGCCAAACCTGCTGCTTGGTGGTGCCAGCCCCTTG
TCCACCTTCTCTTGAGGCCACAGAACTCCCTGGGGCTGGGGCCTCTTTCTCTGGCCTCCCCTGTGCACCTGGGGGGTCCTGGCCCCTGTG
ATGCTCCCCCATCCCCACCCACTTCTACATCCATCCACACCCCAGGGTGAGCTGGAGCTCCAGGCTGGCCAGGCTGAACCTCGCACACAC
GCAGAGTTCTGCTCCCTGAGGGGGGCCCGGGAGGGGCTCCAGCAGGAGGCCGTGGGTGCCATTCGGGGGAAAGTGGGGGAACGACACACA
CTTCACCTGCAAGGGCCGACAACGCAGGGGACACCGTGCCGGCTTCAGACACTCCCAGCGCCCACTCTTACAGGCCCAGGACTGGAGCTT
TCTCTGGCCAAGTTTCAGGCCAATGATCCCCGCATGGTGTTGGGGGTGCTGGTGTGTCTTGGTGCCTGGACTTGAGTCTCACCCTACAGA

>5226_5226_5_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000318562_length(amino acids)=1312AA_BP=645
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP
PDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEF
SHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIR
IAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALL
LSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEDT
KRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRS
QTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHR
GGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLT
LRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWE
SLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHT
HRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTH
KLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNK

--------------------------------------------------------------
>5226_5226_6_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000526198_length(transcript)=4181nt_BP=2097nt
CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC
GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG
GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA
TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC
TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC
TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC
TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC
GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG
CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA
ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG
GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGCCTG
GAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCCATC
AGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACCAAC
CTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTCATC
AACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCACAG
ATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAGAAG
TACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTACCGA
GTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCACGAG
AACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTCCAC
CTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCGGAG
GTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTACCTG
CGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTGGCA
AAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCTGAG
CCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATCCGG
AAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGACATC
GAGTCACAGAGTGCCCAGACCCCGGGTGCGAGTCGTGTCCGCGCGATGTACCCGCAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTG
CAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTGCTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTC
CACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAGGACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATG
CGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGGCAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTC
CAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGCCCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCG
CAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAGACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTG
GCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAGCGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGC
GTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATCGACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAG
CTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCACTTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGC
CCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGATGCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCG
CTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAGTGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCAC
AGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGGGAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCA
GTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACTTCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCC
CCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAGTACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAG
CTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGCCGGCAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTAC
GTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGCGCCCCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGC
CCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAGCTCATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAA
ATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAGCGCAGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCG
GACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGGATCGTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCC
CTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTCCGCGTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAG
CAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCATTCCATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCT

>5226_5226_6_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000526198_length(amino acids)=1328AA_BP=645
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP
PDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEF
SHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIR
IAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALL
LSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEDT
KRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQSAQTPGASRVRAMY
PQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQS
ILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRK
KGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAV
DFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSE
PTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAP
FEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIV

--------------------------------------------------------------
>5226_5226_7_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000530636_length(transcript)=4150nt_BP=2097nt
CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC
GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG
GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA
TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC
TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC
TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC
TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC
GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG
CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA
ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG
GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGCCTG
GAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCCATC
AGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACCAAC
CTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTCATC
AACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCACAG
ATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAGAAG
TACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTACCGA
GTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCACGAG
AACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTCCAC
CTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCGGAG
GTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTACCTG
CGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTGGCA
AAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCTGAG
CCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATCCGG
AAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGACATC
GAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTGCTG
CTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAGGAC
ATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGGCAG
TCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGCCCG
CAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAGACG
CAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAGCGG
AAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATCGAC
TGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCACTTC
CTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGATGCC
GTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAGTGG
CCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGGGAG
GTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACTTCA
GAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAGTAC
GTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGCCGG
CAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGCGCC
CCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAGCTC
ATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAGCGC
AGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGGATC
GTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTCCGC
GTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCATTCC
ATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCTTGGGCTGGGGCCTGCGGAGGGGAAGCCCACCCACAATGCATGGAGTAT

>5226_5226_7_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000530636_length(amino acids)=1312AA_BP=645
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP
PDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEF
SHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIR
IAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALL
LSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEDT
KRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRS
QTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHR
GGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLT
LRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWE
SLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHT
HRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTH
KLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNK

--------------------------------------------------------------
>5226_5226_8_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000533256_length(transcript)=4823nt_BP=2097nt
CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC
GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG
GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA
TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC
TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC
TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC
TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC
GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG
CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA
ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG
GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGCCTG
GAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCCATC
AGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACCAAC
CTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTCATC
AACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCACAG
ATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAGAAG
TACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTACCGA
GTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCACGAG
AACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTCCAC
CTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCGGAG
GTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTACCTG
CGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTGGCA
AAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCTGAG
CCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATCCGG
AAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGACATC
GAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTGCTG
CTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAGGAC
ATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGGCAG
TCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGCCCG
CAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAGACG
CAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAGCGG
AAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATCGAC
TGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCACTTC
CTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGATGCC
GTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAGTGG
CCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGGGAG
GTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACTTCA
GAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAGTAC
GTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGCCGG
CAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGCGCC
CCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAGCTC
ATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAGCGC
AGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGGATC
GTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTCCGC
GTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCATTCC
ATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCTTGGGCTGGGGCCTGCGGAGGGGAAGCCCACCCACAATGCATGGAGTAT
TATTTTTATATGTGTATGTATTTTGTATCAAGGACACGGAGGGGGTGTGGTGCTGGCTAGAGGTCCCTGCCCCTGTCTGGAGGCACAACG
CCCATCCTTAGGCCAAACAGTACCCAAGGCCTCAGCCCACACCAAGACTAATCTCAGCCAAACCTGCTGCTTGGTGGTGCCAGCCCCTTG
TCCACCTTCTCTTGAGGCCACAGAACTCCCTGGGGCTGGGGCCTCTTTCTCTGGCCTCCCCTGTGCACCTGGGGGGTCCTGGCCCCTGTG
ATGCTCCCCCATCCCCACCCACTTCTACATCCATCCACACCCCAGGGTGAGCTGGAGCTCCAGGCTGGCCAGGCTGAACCTCGCACACAC
GCAGAGTTCTGCTCCCTGAGGGGGGCCCGGGAGGGGCTCCAGCAGGAGGCCGTGGGTGCCATTCGGGGGAAAGTGGGGGAACGACACACA
CTTCACCTGCAAGGGCCGACAACGCAGGGGACACCGTGCCGGCTTCAGACACTCCCAGCGCCCACTCTTACAGGCCCAGGACTGGAGCTT
TCTCTGGCCAAGTTTCAGGCCAATGATCCCCGCATGGTGTTGGGGGTGCTGGTGTGTCTTGGTGCCTGGACTTGAGTCTCACCCTACAGA

>5226_5226_8_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000533256_length(amino acids)=1312AA_BP=645
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP
PDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEF
SHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIR
IAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALL
LSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEDT
KRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRS
QTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHR
GGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLT
LRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWE
SLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHT
HRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTH
KLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AP2A2-EPS8L2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AP2A2-EPS8L2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AP2A2-EPS8L2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source