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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MCRS1-MCRS1 (FusionGDB2 ID:52293)

Fusion Gene Summary for MCRS1-MCRS1

check button Fusion gene summary
Fusion gene informationFusion gene name: MCRS1-MCRS1
Fusion gene ID: 52293
HgeneTgene
Gene symbol

MCRS1

MCRS1

Gene ID

10445

10445

Gene namemicrospherule protein 1microspherule protein 1
SynonymsICP22BP|INO80Q|MCRS2|MSP58|P78ICP22BP|INO80Q|MCRS2|MSP58|P78
Cytomap

12q13.12

12q13.12

Type of geneprotein-codingprotein-coding
Descriptionmicrospherule protein 158 kDa microspherule proteinINO80 complex subunit JINO80 complex subunit Qcell cycle-regulated factor (78 kDa)cell cycle-regulated factor p78microspherule protein 158 kDa microspherule proteinINO80 complex subunit JINO80 complex subunit Qcell cycle-regulated factor (78 kDa)cell cycle-regulated factor p78
Modification date2020032020200320
UniProtAcc

Q96EZ8

Q96EZ8

Ensembl transtripts involved in fusion geneENST00000343810, ENST00000357123, 
ENST00000546244, ENST00000547182, 
ENST00000550165, 		ENST00000343810, 
ENST00000546244, ENST00000550165, 
ENST00000357123, ENST00000547182, 
Fusion gene scores* DoF score6 X 7 X 4=1684 X 5 X 3=60
# samples 85
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MCRS1 [Title/Abstract] AND MCRS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMCRS1(49952446)-MCRS1(49952502), # samples:1
MCRS1(49953262)-MCRS1(49961911), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMCRS1

GO:0043981

histone H4-K5 acetylation

20018852

HgeneMCRS1

GO:0043982

histone H4-K8 acetylation

20018852

HgeneMCRS1

GO:0043984

histone H4-K16 acetylation

20018852

HgeneMCRS1

GO:1904751

positive regulation of protein localization to nucleolus

16571602

TgeneMCRS1

GO:0043981

histone H4-K5 acetylation

20018852

TgeneMCRS1

GO:0043982

histone H4-K8 acetylation

20018852

TgeneMCRS1

GO:0043984

histone H4-K16 acetylation

20018852

TgeneMCRS1

GO:1904751

positive regulation of protein localization to nucleolus

16571602


check buttonFusion gene breakpoints across MCRS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MCRS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW878083MCRS1chr12

49952446

-MCRS1chr12

49952502

+
ChiTaRS5.0N/AW26888MCRS1chr12

49953262

+MCRS1chr12

49961911

-


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Fusion Gene ORF analysis for MCRS1-MCRS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000343810ENST00000343810MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000343810ENST00000546244MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000343810ENST00000546244MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-3CDSENST00000343810ENST00000550165MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000357123ENST00000343810MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000357123ENST00000546244MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000357123ENST00000546244MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-3CDSENST00000357123ENST00000550165MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000546244ENST00000343810MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000546244ENST00000546244MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000546244ENST00000546244MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-3CDSENST00000546244ENST00000550165MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000547182ENST00000343810MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000547182ENST00000546244MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000547182ENST00000546244MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-3CDSENST00000547182ENST00000550165MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000550165ENST00000343810MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000550165ENST00000546244MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-3CDSENST00000550165ENST00000546244MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-3CDSENST00000550165ENST00000550165MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-5UTRENST00000343810ENST00000343810MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-5UTRENST00000343810ENST00000357123MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-5UTRENST00000343810ENST00000547182MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-5UTRENST00000357123ENST00000343810MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-5UTRENST00000357123ENST00000357123MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-5UTRENST00000357123ENST00000547182MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-5UTRENST00000546244ENST00000343810MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-5UTRENST00000546244ENST00000357123MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-5UTRENST00000546244ENST00000547182MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-5UTRENST00000547182ENST00000343810MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-5UTRENST00000547182ENST00000357123MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-5UTRENST00000547182ENST00000547182MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-5UTRENST00000550165ENST00000343810MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-5UTRENST00000550165ENST00000357123MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-5UTRENST00000550165ENST00000547182MCRS1chr12

49952446

-MCRS1chr12

49952502

+
intron-intronENST00000343810ENST00000357123MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000343810ENST00000547182MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000343810ENST00000550165MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000357123ENST00000357123MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000357123ENST00000547182MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000357123ENST00000550165MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000546244ENST00000357123MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000546244ENST00000547182MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000546244ENST00000550165MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000547182ENST00000357123MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000547182ENST00000547182MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000547182ENST00000550165MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000550165ENST00000357123MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000550165ENST00000547182MCRS1chr12

49953262

+MCRS1chr12

49961911

-
intron-intronENST00000550165ENST00000550165MCRS1chr12

49953262

+MCRS1chr12

49961911

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MCRS1-MCRS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MCRS1-MCRS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:49952446/:49952502)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MCRS1

Q96EZ8

MCRS1

Q96EZ8

FUNCTION: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602). {ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852}.FUNCTION: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602). {ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MCRS1-MCRS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MCRS1-MCRS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MCRS1-MCRS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MCRS1-MCRS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource