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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MDC1-SNX29 (FusionGDB2 ID:52337)

Fusion Gene Summary for MDC1-SNX29

Fusion gene summary

Fusion gene information	Fusion gene name: MDC1-SNX29
	Fusion gene ID: 52337
		Hgene	Tgene
	Gene symbol	MDC1	SNX29
	Gene ID	9656	92017
	Gene name	mediator of DNA damage checkpoint 1	sorting nexin 29
	Synonyms	NFBD1	A-388D4.1\|RUNDC2A
	Cytomap	6p21.33	16p13.13-p13.12
	Type of gene	protein-coding	protein-coding
	Description	mediator of DNA damage checkpoint protein 1homologue to Drosophila photoreceptor protein calphotinnuclear factor with BRCT domains 1	sorting nexin-29RUN domain containing 2ARUN domain-containing protein 2A
	Modification date	20200315	20200313
	UniProtAcc	Q14676	.
	Ensembl transtripts involved in fusion gene	ENST00000376405, ENST00000376406, ENST00000383566, ENST00000420019, ENST00000420320, ENST00000427406, ENST00000435664, ENST00000440369, ENST00000449153, ENST00000467476, ENST00000473187, ENST00000481026, ENST00000481547, ENST00000482029, ENST00000494654, ENST00000494715, ENST00000495325, ENST00000546487, ENST00000546539, ENST00000547047, ENST00000547353, ENST00000547681, ENST00000547700, ENST00000547874, ENST00000548103, ENST00000548112, ENST00000548248, ENST00000548433, ENST00000548542, ENST00000548827, ENST00000549428, ENST00000550004, ENST00000550408, ENST00000550500, ENST00000550688, ENST00000551204, ENST00000551460, ENST00000551740, ENST00000552263, ENST00000552349, ENST00000552474, ENST00000552522, ENST00000553048, ENST00000553196,	ENST00000306030, ENST00000323433, ENST00000566228, ENST00000568359,
Fusion gene scores	* DoF score	3 X 3 X 1=9	15 X 15 X 6=1350
	# samples	3	16
	** MAII score	log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(16/1350*10)=-3.07681559705083 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MDC1 [Title/Abstract] AND SNX29 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MDC1(30667584)-SNX29(12305616), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MDC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SNX29 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BG575268	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+

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Fusion Gene ORF analysis for MDC1-SNX29

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000376405	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
5CDS-intron	ENST00000376405	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
5CDS-intron	ENST00000376405	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
5CDS-intron	ENST00000376405	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
5CDS-intron	ENST00000376406	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
5CDS-intron	ENST00000376406	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
5CDS-intron	ENST00000376406	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
5CDS-intron	ENST00000376406	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000383566	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000383566	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000383566	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000383566	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000420019	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000420019	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000420019	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000420019	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000420320	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000420320	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000420320	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000420320	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000427406	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000427406	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000427406	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000427406	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000435664	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000435664	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000435664	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000435664	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000440369	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000440369	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000440369	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000440369	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000449153	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000449153	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000449153	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000449153	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000467476	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000467476	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000467476	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000467476	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000473187	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000473187	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000473187	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000473187	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000481026	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000481026	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000481026	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000481026	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000481547	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000481547	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000481547	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000481547	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000482029	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000482029	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000482029	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000482029	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000494654	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000494654	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000494654	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000494654	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000494715	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000494715	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000494715	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000494715	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000495325	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000495325	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000495325	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000495325	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000546487	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000546487	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000546487	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000546487	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000546539	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000546539	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000546539	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000546539	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547047	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547047	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547047	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547047	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547353	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547353	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547353	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547353	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547681	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547681	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547681	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547681	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547700	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547700	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547700	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547700	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547874	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547874	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547874	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000547874	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548103	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548103	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548103	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548103	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548112	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548112	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548112	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548112	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548248	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548248	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548248	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548248	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548433	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548433	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548433	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548433	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548542	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548542	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548542	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548542	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548827	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548827	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548827	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000548827	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000549428	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000549428	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000549428	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000549428	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550004	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550004	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550004	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550004	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550408	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550408	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550408	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550408	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550500	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550500	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550500	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550500	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550688	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550688	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550688	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000550688	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000551204	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000551204	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000551204	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000551204	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000551460	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000551460	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000551460	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000551460	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000551740	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000551740	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000551740	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000551740	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552263	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552263	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552263	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552263	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552349	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552349	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552349	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552349	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552474	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552474	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552474	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552474	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552522	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552522	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552522	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000552522	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000553048	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000553048	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000553048	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000553048	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000553196	ENST00000306030	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000553196	ENST00000323433	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000553196	ENST00000566228	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+
intron-intron	ENST00000553196	ENST00000568359	MDC1	chr6	30667584	-	SNX29	chr16	12305616	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MDC1-SNX29

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MDC1-SNX29

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30667584/:12305616)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MDC1 Q14676	.
FUNCTION: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. {ECO:0000269\|PubMed:12475977, ECO:0000269\|PubMed:12499369, ECO:0000269\|PubMed:12551934, ECO:0000269\|PubMed:12607003, ECO:0000269\|PubMed:12607004, ECO:0000269\|PubMed:12607005, ECO:0000269\|PubMed:12611903, ECO:0000269\|PubMed:14695167, ECO:0000269\|PubMed:15201865, ECO:0000269\|PubMed:15377652}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MDC1-SNX29

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MDC1-SNX29

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MDC1-SNX29

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MDC1-SNX29

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source