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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MDFIC-PAPOLA (FusionGDB2 ID:52339)

Fusion Gene Summary for MDFIC-PAPOLA

check button Fusion gene summary
Fusion gene informationFusion gene name: MDFIC-PAPOLA
Fusion gene ID: 52339
HgeneTgene
Gene symbol

MDFIC

PAPOLA

Gene ID

29969

10914

Gene nameMyoD family inhibitor domain containingpoly(A) polymerase alpha
SynonymsHIC|MDFIC1PAP|PAP-alpha
Cytomap

7q31.1-q31.2

14q32.2

Type of geneprotein-codingprotein-coding
DescriptionmyoD family inhibitor domain-containing proteinI-mfa domain-containing proteinpoly(A) polymerase alphapolynucleotide adenylyltransferase alpha
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000257724, ENST00000393486, 
ENST00000423503, ENST00000448022, 
ENST00000392990, ENST00000554130, 
ENST00000557320, ENST00000557471, 
ENST00000216277, 
Fusion gene scores* DoF score5 X 3 X 4=607 X 10 X 6=420
# samples 58
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/420*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MDFIC [Title/Abstract] AND PAPOLA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMDFIC(114582452)-PAPOLA(97003313), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDFIC

GO:0007257

activation of JUN kinase activity

12192039

HgeneMDFIC

GO:0030111

regulation of Wnt signaling pathway

12192039

HgeneMDFIC

GO:0045893

positive regulation of transcription, DNA-templated

12944466

HgeneMDFIC

GO:0050434

positive regulation of viral transcription

10671520

TgenePAPOLA

GO:0006378

mRNA polyadenylation

7590244|19224921

TgenePAPOLA

GO:0031440

regulation of mRNA 3'-end processing

19224921


check buttonFusion gene breakpoints across MDFIC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PAPOLA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-8574-01AMDFICchr7

114582452

+PAPOLAchr14

97003313

+


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Fusion Gene ORF analysis for MDFIC-PAPOLA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000257724ENST00000392990MDFICchr7

114582452

+PAPOLAchr14

97003313

+
5CDS-intronENST00000257724ENST00000554130MDFICchr7

114582452

+PAPOLAchr14

97003313

+
5CDS-intronENST00000257724ENST00000557320MDFICchr7

114582452

+PAPOLAchr14

97003313

+
5CDS-intronENST00000257724ENST00000557471MDFICchr7

114582452

+PAPOLAchr14

97003313

+
5CDS-intronENST00000393486ENST00000392990MDFICchr7

114582452

+PAPOLAchr14

97003313

+
5CDS-intronENST00000393486ENST00000554130MDFICchr7

114582452

+PAPOLAchr14

97003313

+
5CDS-intronENST00000393486ENST00000557320MDFICchr7

114582452

+PAPOLAchr14

97003313

+
5CDS-intronENST00000393486ENST00000557471MDFICchr7

114582452

+PAPOLAchr14

97003313

+
In-frameENST00000257724ENST00000216277MDFICchr7

114582452

+PAPOLAchr14

97003313

+
In-frameENST00000393486ENST00000216277MDFICchr7

114582452

+PAPOLAchr14

97003313

+
intron-3CDSENST00000423503ENST00000216277MDFICchr7

114582452

+PAPOLAchr14

97003313

+
intron-3CDSENST00000448022ENST00000216277MDFICchr7

114582452

+PAPOLAchr14

97003313

+
intron-intronENST00000423503ENST00000392990MDFICchr7

114582452

+PAPOLAchr14

97003313

+
intron-intronENST00000423503ENST00000554130MDFICchr7

114582452

+PAPOLAchr14

97003313

+
intron-intronENST00000423503ENST00000557320MDFICchr7

114582452

+PAPOLAchr14

97003313

+
intron-intronENST00000423503ENST00000557471MDFICchr7

114582452

+PAPOLAchr14

97003313

+
intron-intronENST00000448022ENST00000392990MDFICchr7

114582452

+PAPOLAchr14

97003313

+
intron-intronENST00000448022ENST00000554130MDFICchr7

114582452

+PAPOLAchr14

97003313

+
intron-intronENST00000448022ENST00000557320MDFICchr7

114582452

+PAPOLAchr14

97003313

+
intron-intronENST00000448022ENST00000557471MDFICchr7

114582452

+PAPOLAchr14

97003313

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393486MDFICchr7114582452+ENST00000216277PAPOLAchr1497003313+40768072452014589
ENST00000257724MDFICchr7114582452+ENST00000216277PAPOLAchr1497003313+40768072452014589

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393486ENST00000216277MDFICchr7114582452+PAPOLAchr1497003313+0.0003173020.99968266
ENST00000257724ENST00000216277MDFICchr7114582452+PAPOLAchr1497003313+0.0003173020.99968266

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Fusion Genomic Features for MDFIC-PAPOLA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MDFIC-PAPOLA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:114582452/chr14:97003313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePAPOLAchr7:114582452chr14:97003313ENST000002162771022504_507343746.0Compositional biasNote=Poly-Lys
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055732009504_5070286.0Compositional biasNote=Poly-Lys
TgenePAPOLAchr7:114582452chr14:97003313ENST000005573200953_570286.0Compositional biasNote=Poly-Glu
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055747107504_5070239.0Compositional biasNote=Poly-Lys
TgenePAPOLAchr7:114582452chr14:97003313ENST000005574710753_570239.0Compositional biasNote=Poly-Glu
TgenePAPOLAchr7:114582452chr14:97003313ENST000002162771022490_507343746.0MotifNuclear localization signal 1
TgenePAPOLAchr7:114582452chr14:97003313ENST000002162771022650_665343746.0MotifNuclear localization signal 2
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055732009490_5070286.0MotifNuclear localization signal 1
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055732009650_6650286.0MotifNuclear localization signal 2
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055747107490_5070239.0MotifNuclear localization signal 1
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055747107650_6650239.0MotifNuclear localization signal 2
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055732009100_1020286.0Nucleotide bindingATP
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055732009113_1150286.0Nucleotide bindingATP
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055732009246_2470286.0Nucleotide bindingATP
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055747107100_1020239.0Nucleotide bindingATP
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055747107113_1150239.0Nucleotide bindingATP
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055747107246_2470239.0Nucleotide bindingATP
TgenePAPOLAchr7:114582452chr14:97003313ENST000002162771022508_643343746.0RegionNote=Ser/Thr-rich
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055732009508_6430286.0RegionNote=Ser/Thr-rich
TgenePAPOLAchr7:114582452chr14:97003313ENST0000055747107508_6430239.0RegionNote=Ser/Thr-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDFICchr7:114582452chr14:97003313ENST00000393486+35166_24372247.0Compositional biasNote=Cys-rich
HgeneMDFICchr7:114582452chr14:97003313ENST00000393486+3574_24672247.0DomainNote=MDFI
TgenePAPOLAchr7:114582452chr14:97003313ENST00000216277102253_57343746.0Compositional biasNote=Poly-Glu
TgenePAPOLAchr7:114582452chr14:97003313ENST000002162771022100_102343746.0Nucleotide bindingATP
TgenePAPOLAchr7:114582452chr14:97003313ENST000002162771022113_115343746.0Nucleotide bindingATP
TgenePAPOLAchr7:114582452chr14:97003313ENST000002162771022246_247343746.0Nucleotide bindingATP


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Fusion Gene Sequence for MDFIC-PAPOLA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52339_52339_1_MDFIC-PAPOLA_MDFIC_chr7_114582452_ENST00000257724_PAPOLA_chr14_97003313_ENST00000216277_length(transcript)=4076nt_BP=807nt
CCCAGGCCGGCTCTGGCCTCCTGACCCAGACAGCGCAGGGCGCGAGGGATCGCGCGGCCGAGCCCGGGTCGCGCCGCTCCCAGCATCGGG
GCCGCTAGCCAAGAGTTCGAGGCCTTCCCGATCCGGATGTGATGAAAAAGAGCAACAGAGGGAGAAGTGTTTCAGGATTGTAGGAGTGGA
AGAGGGGAAAGAGAGGCAGAGAGGGGGAAGGCCCCCTCGCAGGGGAGCCGGCTGGAGTGAGCTGGCTGGAAAGAGGGGGCGGAGTGCGCG
GAGTCAGAGCCGCCACCGCTGCCGCAGTTGCCGCCACTGCGGCGTCTGGGCTGAGCCGGAGGGAGGCGGGAGGACGCGCAGGGGCGGCCG
CCGCCGTCGTCAGGCCACCGGGGCGAAAATGCGGCCGCTGCCGGAGGCTCGCTAACTTTCCGGGGCGGAAGAGGAGGAGGAGGAGGAGGA
AGGGGCTTGGAGCGACTACGGGGGGATGCGGAGAAGCAGTCAGTTCCCTGCACCCAGCACCTCACAGCCCTTCCTCCGTGCGCCCTGCCG
GGCGGCGAGCTAGGCGGCAGCGGCGCGGCGCGGGCTCGGCGGAGCGGCCCATGTCCGGCGCGGGCGAAGCCCTCGCTCCCGGGCCCGTGG
GGCCGCAGCGCGTGGCCGAGGCGGGCGGCGGCCAGCTGGGCTCCACAGCCCAGGGAAAATGTGATAAAGACAATACTGAGAAAGATATAA
CTCAAGCTACCAATAGCCACTTCACACATGGAGAGATGCAAGACCAGTCCATTTGGGGAAATCCTTCGGATGGTGAACTCATTAGAAGTC
TTGCTATCACAGATGAAATTTTGCTGAGTAAGGCAGAGTGGTCCAAACTTTTTGAAGCTCCAAACTTCTTTCAAAAGTACAAGCATTATA
TTGTACTTCTAGCAAGTGCACCAACAGAAAAACAACGCCTGGAATGGGTGGGCTTGGTGGAATCAAAAATCCGAATCCTGGTTGGAAGCT
TGGAGAAGAATGAATTTATTACACTGGCTCATGTGAATCCCCAGTCATTTCCAGCACCCAAAGAAAATCCCGACAAGGAAGAATTTCGCA
CGATGTGGGTGATTGGGTTAGTGTTTAAAAAAACAGAAAACTCTGAAAACCTCAGTGTTGATCTCACCTATGATATTCAGTCTTTCACAG
ATACAGTTTATAGGCAAGCAATAAACAGCAAGATGTTTGAGGTGGATATGAAAATTGCTGCAATGCATGTAAAAAGAAAGCAACTCCATC
AACTACTACCTAATCATGTGCTTCAGAAAAAGAAAAAGCATTCAACAGAAGGTGTCAAATTGACAGCTCTCAATGACAGCAGCCTCGACT
TGTCTATGGACAGTGATAACAGCATGTCTGTGCCTTCACCTACTAGTGCTACGAAGACCAGTCCATTGAACAGTTCTGGCAGCTCTCAGG
GCAGAAACAGTCCTGCTCCAGCTGTAACAGCAGCATCTGTGACCAACATACAGGCTACTGAAGTTTCTGTGCCACAAGTAAATTCCAGTG
AAAGCTCAGGGGGTACATCGAGTGAAAGCATTCCTCAAACTGCCACACAACCAGCCATTTCTCCACCACCAAAGCCTACGGTCTCCAGAG
TTGTTTCTTCAACACGTCTGGTAAACCCACCACCTAGATCTTCAGGAAATGCAGCAACTTCAGGAAATGCAGCAACAAAAATACCTACTC
CTATAGTAGGAGTCAAGAGGACATCCTCACCTCATAAAGAAGAGAGTCCCAAGAAAACCAAAACAGAAGAGGATGAAACAAGTGAAGATG
CTAACTGTCTTGCTTTGAGTGGACATGATAAAACAGAAGCAAAGGAACAACTTGATACAGAGACAAGTACAACTCAATCAGAAACTATTC
AGACAGCGGCTTCTCTGTTGGCCTCTCAGAAAACATCCAGTACAGACCTTTCTGATATCCCTGCTCTCCCTGCAAATCCTATTCCTGTTA
TCAAGAATTCAATAAAACTGAGATTGAATCGGTAAAAACAACCTCAGGGGTCCATAAACAATATCTGCCAACTCAACCTGTTGTCTTCAA
ATGCTAAAAAAGGAGAATGGAGGGTACAAGACTAGACATGACTGAAATGGATTTGGGTTTTTTGGTGACCTCCCTTACTGGGCTAATCAG
CACTTGATCGGAAGTCCAGGTTAGTATGTGAAGCCAGGAGTACTATTATTATTGTGTTAGCAACAGTTGCATTAACTATTTCAAAAATTA
CTGCCTTTAAAAAAAACAACCTCAAGCTATATTTGTATTCATAATTGACATCTGGATTGGGTTTATGTTTGATGCATTGTTTGGAAAATT
TGCAATACAAACTGGCATAAGAATTACTTATTCTGATGATGCACTTTTATGTATTTTTCATTAGAAAGTAGAACTAATTTTAGATTTTCA
GCTTGATGGATTTTCAGTTTTTCCTGAAGAATTTTCTTTACCATTAGTCTTCAAATTGGATACTGTTGTGCAGTGGTGTACTGTTATACT
TCAGAGAAAGGGTAAGAGTACATCTAGTTCAGTTCCTATGAGGTAGCTGTAACCCTTAAAAATGAAACGTCAACTCTAGGGTACATTTGA
CATTGAAAGAATAGTTAGGAAATAACTTGGTTTTGATAGGGTCATGATTAAGAAATGATATATTGGTTTTATTTATGGAATTGTTTTATA
GTGCATACAAATCAGCGATCAGCCAGCAAATATTTTTCTTTGAGCTTGTGAAAGCTCTGTGTTCTTTTGCCTTCAATCTGTTGTCTTCAA
AACAAACAAACAAAAAAAGCTTCTTGCGCCTTTCCCTCCCCTGTTTTCTTCCTTTTTCTTTTTGCTTGTATGCACAAGGTAGGACTTACT
TCGTAAGAAACAAAATGCCAGTATTTTCTTAAGCCATGATGTGAAACCAATGACCCTGTGACCACATGGCACAGAACACTAAATTTTGGT
CCCATGGCTGAAACTTGAGGGTGACTAAAAGTAATGCCTGTGAAACATGATATCTATCTGGGATGGCCATTTGATCTCTAAAAGGAATTT
TGTACACTCCACAGAACTCCTATCTATAGTAAAATTGATTTTCAGTTTTAAATGTGGGCAAAAAGGCATTTTCTCCAAGATTTTAAAACT
AATTCTTATTTTTAAATGGTTTACCAAAATTTGTCAGTACATTTTACGTGTAGAAGCATTTTAAAAATCATTTCTAGCAAGCACTTGACA
TCTAGTCAGCTCTCTACTCCTTTATTTTGTTTTATCAAAAGATTAAGAGCTCCTTTCTTTGAATAAAATAATTTCTCATAATTAAGCAGT
AGAAGATCTATCTTCACAAAGTATGAGGGATGCCAGATGTTGATAAACTTACTCTTTCTGAATCTGGACAAAGTCGACTTAACAGATTTT
TCTGATGAGCATGTTTTATGAATCCTCCATTGTGCTCCATTCTATCACATGTGCATTTTTCATGTTAAACTGCAATTACTTAATCTCTTC
CCCTATCCTTCTAAATTAATTTTCTGAAGTTGGAGTGTAGTCTTTTCCCCCTTAGGCTATGCATTAATCGAAGCTTTCTTTTCACCATGA
CTTTATAATGTCTAGTAAACAATATTTCTACTTCCCACATCTTTGCTTTACACAGTCACCTTGCCCTTCCTTCCACCACCGAAGAAAAAA
GATGGTCATACTAACAGGTGAAATGTACAAGGTGTCTGTGTGTTTTGTGTAGCTTCAGAGTTAGATTGAAATTACCAGGCACAGATTTAG
TCTTGTCATTTTGTTTACACATTGGGGAAAACAATTCAGTTTATTAAACGTTTCATGTAACTGCACCCAAGTTTTGCCAAGCTGGAAACT
TGGACCTTTTCTGTGTAGTGACTTTTTAATTATAGTTTTCATAACCTGGAGATCAGACTGTTGCTTTCGCATGATGTATGTAGTGTCTCA
TGACTGGAGTTTGCTTTGTTTTATAGTATCTGTACTCCTTGTATTTTTCAAGAGCTATTTTGTAAACAGATGATGTATTTCTCCATTGAA

>52339_52339_1_MDFIC-PAPOLA_MDFIC_chr7_114582452_ENST00000257724_PAPOLA_chr14_97003313_ENST00000216277_length(amino acids)=589AA_BP=188
MERGGGVRGVRAATAAAVAATAASGLSRREAGGRAGAAAAVVRPPGRKCGRCRRLANFPGRKRRRRRRKGLGATTGGCGEAVSSLHPAPH
SPSSVRPAGRRARRQRRGAGSAERPMSGAGEALAPGPVGPQRVAEAGGGQLGSTAQGKCDKDNTEKDITQATNSHFTHGEMQDQSIWGNP
SDGELIRSLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKE
NPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLT
ALNDSSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTATQPAISP
PPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTET

--------------------------------------------------------------
>52339_52339_2_MDFIC-PAPOLA_MDFIC_chr7_114582452_ENST00000393486_PAPOLA_chr14_97003313_ENST00000216277_length(transcript)=4076nt_BP=807nt
CCCAGGCCGGCTCTGGCCTCCTGACCCAGACAGCGCAGGGCGCGAGGGATCGCGCGGCCGAGCCCGGGTCGCGCCGCTCCCAGCATCGGG
GCCGCTAGCCAAGAGTTCGAGGCCTTCCCGATCCGGATGTGATGAAAAAGAGCAACAGAGGGAGAAGTGTTTCAGGATTGTAGGAGTGGA
AGAGGGGAAAGAGAGGCAGAGAGGGGGAAGGCCCCCTCGCAGGGGAGCCGGCTGGAGTGAGCTGGCTGGAAAGAGGGGGCGGAGTGCGCG
GAGTCAGAGCCGCCACCGCTGCCGCAGTTGCCGCCACTGCGGCGTCTGGGCTGAGCCGGAGGGAGGCGGGAGGACGCGCAGGGGCGGCCG
CCGCCGTCGTCAGGCCACCGGGGCGAAAATGCGGCCGCTGCCGGAGGCTCGCTAACTTTCCGGGGCGGAAGAGGAGGAGGAGGAGGAGGA
AGGGGCTTGGAGCGACTACGGGGGGATGCGGAGAAGCAGTCAGTTCCCTGCACCCAGCACCTCACAGCCCTTCCTCCGTGCGCCCTGCCG
GGCGGCGAGCTAGGCGGCAGCGGCGCGGCGCGGGCTCGGCGGAGCGGCCCATGTCCGGCGCGGGCGAAGCCCTCGCTCCCGGGCCCGTGG
GGCCGCAGCGCGTGGCCGAGGCGGGCGGCGGCCAGCTGGGCTCCACAGCCCAGGGAAAATGTGATAAAGACAATACTGAGAAAGATATAA
CTCAAGCTACCAATAGCCACTTCACACATGGAGAGATGCAAGACCAGTCCATTTGGGGAAATCCTTCGGATGGTGAACTCATTAGAAGTC
TTGCTATCACAGATGAAATTTTGCTGAGTAAGGCAGAGTGGTCCAAACTTTTTGAAGCTCCAAACTTCTTTCAAAAGTACAAGCATTATA
TTGTACTTCTAGCAAGTGCACCAACAGAAAAACAACGCCTGGAATGGGTGGGCTTGGTGGAATCAAAAATCCGAATCCTGGTTGGAAGCT
TGGAGAAGAATGAATTTATTACACTGGCTCATGTGAATCCCCAGTCATTTCCAGCACCCAAAGAAAATCCCGACAAGGAAGAATTTCGCA
CGATGTGGGTGATTGGGTTAGTGTTTAAAAAAACAGAAAACTCTGAAAACCTCAGTGTTGATCTCACCTATGATATTCAGTCTTTCACAG
ATACAGTTTATAGGCAAGCAATAAACAGCAAGATGTTTGAGGTGGATATGAAAATTGCTGCAATGCATGTAAAAAGAAAGCAACTCCATC
AACTACTACCTAATCATGTGCTTCAGAAAAAGAAAAAGCATTCAACAGAAGGTGTCAAATTGACAGCTCTCAATGACAGCAGCCTCGACT
TGTCTATGGACAGTGATAACAGCATGTCTGTGCCTTCACCTACTAGTGCTACGAAGACCAGTCCATTGAACAGTTCTGGCAGCTCTCAGG
GCAGAAACAGTCCTGCTCCAGCTGTAACAGCAGCATCTGTGACCAACATACAGGCTACTGAAGTTTCTGTGCCACAAGTAAATTCCAGTG
AAAGCTCAGGGGGTACATCGAGTGAAAGCATTCCTCAAACTGCCACACAACCAGCCATTTCTCCACCACCAAAGCCTACGGTCTCCAGAG
TTGTTTCTTCAACACGTCTGGTAAACCCACCACCTAGATCTTCAGGAAATGCAGCAACTTCAGGAAATGCAGCAACAAAAATACCTACTC
CTATAGTAGGAGTCAAGAGGACATCCTCACCTCATAAAGAAGAGAGTCCCAAGAAAACCAAAACAGAAGAGGATGAAACAAGTGAAGATG
CTAACTGTCTTGCTTTGAGTGGACATGATAAAACAGAAGCAAAGGAACAACTTGATACAGAGACAAGTACAACTCAATCAGAAACTATTC
AGACAGCGGCTTCTCTGTTGGCCTCTCAGAAAACATCCAGTACAGACCTTTCTGATATCCCTGCTCTCCCTGCAAATCCTATTCCTGTTA
TCAAGAATTCAATAAAACTGAGATTGAATCGGTAAAAACAACCTCAGGGGTCCATAAACAATATCTGCCAACTCAACCTGTTGTCTTCAA
ATGCTAAAAAAGGAGAATGGAGGGTACAAGACTAGACATGACTGAAATGGATTTGGGTTTTTTGGTGACCTCCCTTACTGGGCTAATCAG
CACTTGATCGGAAGTCCAGGTTAGTATGTGAAGCCAGGAGTACTATTATTATTGTGTTAGCAACAGTTGCATTAACTATTTCAAAAATTA
CTGCCTTTAAAAAAAACAACCTCAAGCTATATTTGTATTCATAATTGACATCTGGATTGGGTTTATGTTTGATGCATTGTTTGGAAAATT
TGCAATACAAACTGGCATAAGAATTACTTATTCTGATGATGCACTTTTATGTATTTTTCATTAGAAAGTAGAACTAATTTTAGATTTTCA
GCTTGATGGATTTTCAGTTTTTCCTGAAGAATTTTCTTTACCATTAGTCTTCAAATTGGATACTGTTGTGCAGTGGTGTACTGTTATACT
TCAGAGAAAGGGTAAGAGTACATCTAGTTCAGTTCCTATGAGGTAGCTGTAACCCTTAAAAATGAAACGTCAACTCTAGGGTACATTTGA
CATTGAAAGAATAGTTAGGAAATAACTTGGTTTTGATAGGGTCATGATTAAGAAATGATATATTGGTTTTATTTATGGAATTGTTTTATA
GTGCATACAAATCAGCGATCAGCCAGCAAATATTTTTCTTTGAGCTTGTGAAAGCTCTGTGTTCTTTTGCCTTCAATCTGTTGTCTTCAA
AACAAACAAACAAAAAAAGCTTCTTGCGCCTTTCCCTCCCCTGTTTTCTTCCTTTTTCTTTTTGCTTGTATGCACAAGGTAGGACTTACT
TCGTAAGAAACAAAATGCCAGTATTTTCTTAAGCCATGATGTGAAACCAATGACCCTGTGACCACATGGCACAGAACACTAAATTTTGGT
CCCATGGCTGAAACTTGAGGGTGACTAAAAGTAATGCCTGTGAAACATGATATCTATCTGGGATGGCCATTTGATCTCTAAAAGGAATTT
TGTACACTCCACAGAACTCCTATCTATAGTAAAATTGATTTTCAGTTTTAAATGTGGGCAAAAAGGCATTTTCTCCAAGATTTTAAAACT
AATTCTTATTTTTAAATGGTTTACCAAAATTTGTCAGTACATTTTACGTGTAGAAGCATTTTAAAAATCATTTCTAGCAAGCACTTGACA
TCTAGTCAGCTCTCTACTCCTTTATTTTGTTTTATCAAAAGATTAAGAGCTCCTTTCTTTGAATAAAATAATTTCTCATAATTAAGCAGT
AGAAGATCTATCTTCACAAAGTATGAGGGATGCCAGATGTTGATAAACTTACTCTTTCTGAATCTGGACAAAGTCGACTTAACAGATTTT
TCTGATGAGCATGTTTTATGAATCCTCCATTGTGCTCCATTCTATCACATGTGCATTTTTCATGTTAAACTGCAATTACTTAATCTCTTC
CCCTATCCTTCTAAATTAATTTTCTGAAGTTGGAGTGTAGTCTTTTCCCCCTTAGGCTATGCATTAATCGAAGCTTTCTTTTCACCATGA
CTTTATAATGTCTAGTAAACAATATTTCTACTTCCCACATCTTTGCTTTACACAGTCACCTTGCCCTTCCTTCCACCACCGAAGAAAAAA
GATGGTCATACTAACAGGTGAAATGTACAAGGTGTCTGTGTGTTTTGTGTAGCTTCAGAGTTAGATTGAAATTACCAGGCACAGATTTAG
TCTTGTCATTTTGTTTACACATTGGGGAAAACAATTCAGTTTATTAAACGTTTCATGTAACTGCACCCAAGTTTTGCCAAGCTGGAAACT
TGGACCTTTTCTGTGTAGTGACTTTTTAATTATAGTTTTCATAACCTGGAGATCAGACTGTTGCTTTCGCATGATGTATGTAGTGTCTCA
TGACTGGAGTTTGCTTTGTTTTATAGTATCTGTACTCCTTGTATTTTTCAAGAGCTATTTTGTAAACAGATGATGTATTTCTCCATTGAA

>52339_52339_2_MDFIC-PAPOLA_MDFIC_chr7_114582452_ENST00000393486_PAPOLA_chr14_97003313_ENST00000216277_length(amino acids)=589AA_BP=188
MERGGGVRGVRAATAAAVAATAASGLSRREAGGRAGAAAAVVRPPGRKCGRCRRLANFPGRKRRRRRRKGLGATTGGCGEAVSSLHPAPH
SPSSVRPAGRRARRQRRGAGSAERPMSGAGEALAPGPVGPQRVAEAGGGQLGSTAQGKCDKDNTEKDITQATNSHFTHGEMQDQSIWGNP
SDGELIRSLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKE
NPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLT
ALNDSSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTATQPAISP
PPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTET

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Fusion Gene PPI Analysis for MDFIC-PAPOLA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MDFIC-PAPOLA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MDFIC-PAPOLA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource