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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AP2A2-TOLLIP (FusionGDB2 ID:5234)

Fusion Gene Summary for AP2A2-TOLLIP

check button Fusion gene summary
Fusion gene informationFusion gene name: AP2A2-TOLLIP
Fusion gene ID: 5234
HgeneTgene
Gene symbol

AP2A2

TOLLIP

Gene ID

161

54472

Gene nameadaptor related protein complex 2 subunit alpha 2toll interacting protein
SynonymsADTAB|CLAPA2|HIP-9|HIP9|HYPJIL-1RAcPIP
Cytomap

11p15.5

11p15.5

Type of geneprotein-codingprotein-coding
DescriptionAP-2 complex subunit alpha-2100 kDa coated vesicle protein Cadapter-related protein complex 2 subunit alpha-2adaptin, alpha Badaptor related protein complex 2 alpha 2 subunitalpha-adaptin C; Huntingtin interacting protein Jalpha2-adaptinclathrin astoll-interacting proteinadapter protein
Modification date2020031320200327
UniProtAcc

O94973

.
Ensembl transtripts involved in fusion geneENST00000332231, ENST00000448903, 
ENST00000534328, ENST00000525891, 
ENST00000528719, ENST00000263646, 
ENST00000317204, ENST00000525159, 
ENST00000527886, ENST00000527938, 
ENST00000542915, 
Fusion gene scores* DoF score13 X 10 X 12=15606 X 5 X 4=120
# samples 226
** MAII scorelog2(22/1560*10)=-2.82597060022495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AP2A2 [Title/Abstract] AND TOLLIP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTOLLIP(1330696)-AP2A2(972062), # samples:2
AP2A2(926088)-TOLLIP(1298483), # samples:2
Anticipated loss of major functional domain due to fusion event.TOLLIP-AP2A2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
AP2A2-TOLLIP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAP2A2

GO:0072583

clathrin-dependent endocytosis

23676497

TgeneTOLLIP

GO:0016310

phosphorylation

1085432

TgeneTOLLIP

GO:0036010

protein localization to endosome

16412388


check buttonFusion gene breakpoints across AP2A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TOLLIP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FS-A1ZA-06AAP2A2chr11

926088

-TOLLIPchr11

1298483

-
ChimerDB4SKCMTCGA-FS-A1ZA-06AAP2A2chr11

926088

+TOLLIPchr11

1298483

-


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Fusion Gene ORF analysis for AP2A2-TOLLIP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000332231ENST00000528719AP2A2chr11

926088

+TOLLIPchr11

1298483

-
5CDS-intronENST00000448903ENST00000528719AP2A2chr11

926088

+TOLLIPchr11

1298483

-
5CDS-intronENST00000534328ENST00000528719AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000332231ENST00000263646AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000332231ENST00000317204AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000332231ENST00000525159AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000332231ENST00000527886AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000332231ENST00000527938AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000448903ENST00000263646AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000448903ENST00000317204AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000448903ENST00000525159AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000448903ENST00000527886AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000448903ENST00000527938AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000534328ENST00000263646AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000534328ENST00000317204AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000534328ENST00000525159AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000534328ENST00000527886AP2A2chr11

926088

+TOLLIPchr11

1298483

-
Frame-shiftENST00000534328ENST00000527938AP2A2chr11

926088

+TOLLIPchr11

1298483

-
In-frameENST00000332231ENST00000542915AP2A2chr11

926088

+TOLLIPchr11

1298483

-
In-frameENST00000448903ENST00000542915AP2A2chr11

926088

+TOLLIPchr11

1298483

-
In-frameENST00000534328ENST00000542915AP2A2chr11

926088

+TOLLIPchr11

1298483

-
intron-3CDSENST00000525891ENST00000263646AP2A2chr11

926088

+TOLLIPchr11

1298483

-
intron-3CDSENST00000525891ENST00000317204AP2A2chr11

926088

+TOLLIPchr11

1298483

-
intron-3CDSENST00000525891ENST00000525159AP2A2chr11

926088

+TOLLIPchr11

1298483

-
intron-3CDSENST00000525891ENST00000527886AP2A2chr11

926088

+TOLLIPchr11

1298483

-
intron-3CDSENST00000525891ENST00000527938AP2A2chr11

926088

+TOLLIPchr11

1298483

-
intron-3CDSENST00000525891ENST00000542915AP2A2chr11

926088

+TOLLIPchr11

1298483

-
intron-intronENST00000525891ENST00000528719AP2A2chr11

926088

+TOLLIPchr11

1298483

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534328AP2A2chr11926088+ENST00000542915TOLLIPchr111298483-180720963524203
ENST00000332231AP2A2chr11926088+ENST00000542915TOLLIPchr111298483-180620863423203
ENST00000448903AP2A2chr11926088+ENST00000542915TOLLIPchr111298483-180620863423203

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534328ENST00000542915AP2A2chr11926088+TOLLIPchr111298483-0.700578870.2994211
ENST00000332231ENST00000542915AP2A2chr11926088+TOLLIPchr111298483-0.705782060.2942179
ENST00000448903ENST00000542915AP2A2chr11926088+TOLLIPchr111298483-0.705782060.2942179

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Fusion Genomic Features for AP2A2-TOLLIP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AP2A2-TOLLIP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:1330696/chr11:972062)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AP2A2

O94973

.
FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:12960147, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAP2A2chr11:926088chr11:1298483ENST00000332231+12211_1222941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:926088chr11:1298483ENST00000448903+12211_1222940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
TgeneTOLLIPchr11:926088chr11:1298483ENST0000031720446229_272203275.0DomainCUE

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAP2A2chr11:926088chr11:1298483ENST00000332231+12257_6122941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:926088chr11:1298483ENST00000332231+1225_8022941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:926088chr11:1298483ENST00000448903+12257_6122940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:926088chr11:1298483ENST00000448903+1225_8022940.0RegionNote=Lipid-binding
TgeneTOLLIPchr11:926088chr11:1298483ENST000003172044628_44203275.0Compositional biasNote=Gln-rich
TgeneTOLLIPchr11:926088chr11:1298483ENST000003172044635_152203275.0DomainC2
TgeneTOLLIPchr11:926088chr11:1298483ENST0000031720446133_136203275.0MotifNote=AIM1
TgeneTOLLIPchr11:926088chr11:1298483ENST0000031720446151_154203275.0MotifNote=AIM2


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Fusion Gene Sequence for AP2A2-TOLLIP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5234_5234_1_AP2A2-TOLLIP_AP2A2_chr11_926088_ENST00000332231_TOLLIP_chr11_1298483_ENST00000542915_length(transcript)=1806nt_BP=208nt
CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC
GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG
GCGGTCTTCATCTCGGATATCCGCAACTGGATGCCCGCTGTCTGTAGCCCCGGCATGGTGCCCGTGGCCCTGCCCCCGGCCGCCGTGAAC
GCCCAGCCCCGCTGTAGCGAGGAGGACCTGAAAGCCATCCAGGACATGTTCCCCAACATGGACCAGGAGGTGATCCGCTCCGTGCTGGAA
GCCCAGCGAGGGAACAAGGATGCCGCCATCAACTCCCTGCTGCAGATGGGGGAGGAGCCATAGAGCCTCTGCCTCGATGCCGTTTTGCCC
CCGCTCTTTGGACACGCCGACCCGGCGCTCCCCAAGGAATGCTGTCCCAACAAGATTCCCGTGAAAGAGCACCCGTGTCGCCCCCTCCCG
TGGACTTCTGTGCCGCCCCGTCCACACCTGTTCTTGGGTGCATGTGGGTTTTCGGTTCCTGGCGGTCCAGGACGGGGCGGGGGCTCCCCT
CCCATCTCGTGCTGGGAGGTCTCAGCGCGCTCTCCTGTCCCTGGGACGTGCGTCTCTCCTTCTCATGCCGTTCTGGAAAATGCTCTTGCT
GTAGAGAGCAGCTGCTTCTGCCAGGGTGTTGGAGGTGGTGGAGCGCCTTCCGATTCCATTCATGGCATTTTGTGATGTGATGTAATTGGA
ATAGAGCTGTTGATTTAAGGCACACACAATCCCTCACACTGTGGGTTTTTTTTAGAACTTCCCAGACGAAAACTCACGCCCTTGCCCTAA
CGCGCTTTGCTGTGAGCCTGGCCCCTGCCCAGGGCTTGGGTCTGGTGAGCTGAGCAGCTTCCTGTGGATGGTGTGGGGCCGGCCTCTGGC
CTGGCTCACCTGGCCACTGTCCAGCCAGCCTTGTGACAGACTCCGGCCTGAAGGCAGAATGAACCCACACCTGGAGTGAGGAAGGGGGCC
TGGCACGGTTGGCCAGGCTCTGCCTGATTGCCAGCCAGCGGGCATCTGAAGCCGGGTCCTTCGCCCGCCGGAGGCTGCCGTCCGTCTCTC
CTGCTGCGCTCGTGCCAGCTCCGTGGGTGTCCTCCCAGGGAGCTTCTCTTCTCAACAGGCCTTGCGAGGCTGGGGTGAGAGGTGATAGAG
GCAGCACTGTGCATGATTCCGAGAGGGTGTGGTGGCACTGCCAGCCGACTGCTGACAGCTTGGGAGCTGCTGTGCCCAGGACGTGGGTTC
AGCGTGGGCGAGGAAAGCCTGGCGAGCGTGGCCCTGTAAAAGCTTTCTGAGGCGGGAGGCGCTCACTTACCTCTGACTGCCTGGGCGCTG
CGTGTAGCATCTTGGCCTACAGGACAGATTTTAGGTGACACCTGGTTATGACAGTCAGAAATTTGAGAAGCTTCTCACAAGTGATGCACT
TTAAATAATCTGCATGCCATTGAGACACCTGCATGTCTGGTGTTTGTGGTTCAAGTGTCTTGCCGCCGGCCTTCGGATGTAAACCCACTG
ATAACGGACAGAAAGAGAATGCCCACAAGTGGGTCTTCTGTGGAAGATGCAGAAGGAGGAAGTTAGTGCTTACATTTTAGTCTTTTTCTC
CCTCAAAAAAATAGGTTAAGTTTCAGTGCCAGCTAGAAAATACTGCTTTCTGCCATCGATTGGGGGTGGTTTTTGTCAAATATACTGTTG

>5234_5234_1_AP2A2-TOLLIP_AP2A2_chr11_926088_ENST00000332231_TOLLIP_chr11_1298483_ENST00000542915_length(amino acids)=203AA_BP=0
MGGEPPPRPGPPGTENPHAPKNRCGRGGTEVHGRGRHGCSFTGILLGQHSLGSAGSACPKSGGKTASRQRLYGSSPICSRELMAASLFPR
WASSTERITSWSMLGNMSWMAFRSSSLQRGWAFTAAGGRATGTMPGLQTAGIQLRISEMKTARPRIPSPLDTAGIFRRSGAASAGGPGRR

--------------------------------------------------------------
>5234_5234_2_AP2A2-TOLLIP_AP2A2_chr11_926088_ENST00000448903_TOLLIP_chr11_1298483_ENST00000542915_length(transcript)=1806nt_BP=208nt
CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC
GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG
GCGGTCTTCATCTCGGATATCCGCAACTGGATGCCCGCTGTCTGTAGCCCCGGCATGGTGCCCGTGGCCCTGCCCCCGGCCGCCGTGAAC
GCCCAGCCCCGCTGTAGCGAGGAGGACCTGAAAGCCATCCAGGACATGTTCCCCAACATGGACCAGGAGGTGATCCGCTCCGTGCTGGAA
GCCCAGCGAGGGAACAAGGATGCCGCCATCAACTCCCTGCTGCAGATGGGGGAGGAGCCATAGAGCCTCTGCCTCGATGCCGTTTTGCCC
CCGCTCTTTGGACACGCCGACCCGGCGCTCCCCAAGGAATGCTGTCCCAACAAGATTCCCGTGAAAGAGCACCCGTGTCGCCCCCTCCCG
TGGACTTCTGTGCCGCCCCGTCCACACCTGTTCTTGGGTGCATGTGGGTTTTCGGTTCCTGGCGGTCCAGGACGGGGCGGGGGCTCCCCT
CCCATCTCGTGCTGGGAGGTCTCAGCGCGCTCTCCTGTCCCTGGGACGTGCGTCTCTCCTTCTCATGCCGTTCTGGAAAATGCTCTTGCT
GTAGAGAGCAGCTGCTTCTGCCAGGGTGTTGGAGGTGGTGGAGCGCCTTCCGATTCCATTCATGGCATTTTGTGATGTGATGTAATTGGA
ATAGAGCTGTTGATTTAAGGCACACACAATCCCTCACACTGTGGGTTTTTTTTAGAACTTCCCAGACGAAAACTCACGCCCTTGCCCTAA
CGCGCTTTGCTGTGAGCCTGGCCCCTGCCCAGGGCTTGGGTCTGGTGAGCTGAGCAGCTTCCTGTGGATGGTGTGGGGCCGGCCTCTGGC
CTGGCTCACCTGGCCACTGTCCAGCCAGCCTTGTGACAGACTCCGGCCTGAAGGCAGAATGAACCCACACCTGGAGTGAGGAAGGGGGCC
TGGCACGGTTGGCCAGGCTCTGCCTGATTGCCAGCCAGCGGGCATCTGAAGCCGGGTCCTTCGCCCGCCGGAGGCTGCCGTCCGTCTCTC
CTGCTGCGCTCGTGCCAGCTCCGTGGGTGTCCTCCCAGGGAGCTTCTCTTCTCAACAGGCCTTGCGAGGCTGGGGTGAGAGGTGATAGAG
GCAGCACTGTGCATGATTCCGAGAGGGTGTGGTGGCACTGCCAGCCGACTGCTGACAGCTTGGGAGCTGCTGTGCCCAGGACGTGGGTTC
AGCGTGGGCGAGGAAAGCCTGGCGAGCGTGGCCCTGTAAAAGCTTTCTGAGGCGGGAGGCGCTCACTTACCTCTGACTGCCTGGGCGCTG
CGTGTAGCATCTTGGCCTACAGGACAGATTTTAGGTGACACCTGGTTATGACAGTCAGAAATTTGAGAAGCTTCTCACAAGTGATGCACT
TTAAATAATCTGCATGCCATTGAGACACCTGCATGTCTGGTGTTTGTGGTTCAAGTGTCTTGCCGCCGGCCTTCGGATGTAAACCCACTG
ATAACGGACAGAAAGAGAATGCCCACAAGTGGGTCTTCTGTGGAAGATGCAGAAGGAGGAAGTTAGTGCTTACATTTTAGTCTTTTTCTC
CCTCAAAAAAATAGGTTAAGTTTCAGTGCCAGCTAGAAAATACTGCTTTCTGCCATCGATTGGGGGTGGTTTTTGTCAAATATACTGTTG

>5234_5234_2_AP2A2-TOLLIP_AP2A2_chr11_926088_ENST00000448903_TOLLIP_chr11_1298483_ENST00000542915_length(amino acids)=203AA_BP=0
MGGEPPPRPGPPGTENPHAPKNRCGRGGTEVHGRGRHGCSFTGILLGQHSLGSAGSACPKSGGKTASRQRLYGSSPICSRELMAASLFPR
WASSTERITSWSMLGNMSWMAFRSSSLQRGWAFTAAGGRATGTMPGLQTAGIQLRISEMKTARPRIPSPLDTAGIFRRSGAASAGGPGRR

--------------------------------------------------------------
>5234_5234_3_AP2A2-TOLLIP_AP2A2_chr11_926088_ENST00000534328_TOLLIP_chr11_1298483_ENST00000542915_length(transcript)=1807nt_BP=209nt
GCTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCC
CGCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCT
GGCGGTCTTCATCTCGGATATCCGCAACTGGATGCCCGCTGTCTGTAGCCCCGGCATGGTGCCCGTGGCCCTGCCCCCGGCCGCCGTGAA
CGCCCAGCCCCGCTGTAGCGAGGAGGACCTGAAAGCCATCCAGGACATGTTCCCCAACATGGACCAGGAGGTGATCCGCTCCGTGCTGGA
AGCCCAGCGAGGGAACAAGGATGCCGCCATCAACTCCCTGCTGCAGATGGGGGAGGAGCCATAGAGCCTCTGCCTCGATGCCGTTTTGCC
CCCGCTCTTTGGACACGCCGACCCGGCGCTCCCCAAGGAATGCTGTCCCAACAAGATTCCCGTGAAAGAGCACCCGTGTCGCCCCCTCCC
GTGGACTTCTGTGCCGCCCCGTCCACACCTGTTCTTGGGTGCATGTGGGTTTTCGGTTCCTGGCGGTCCAGGACGGGGCGGGGGCTCCCC
TCCCATCTCGTGCTGGGAGGTCTCAGCGCGCTCTCCTGTCCCTGGGACGTGCGTCTCTCCTTCTCATGCCGTTCTGGAAAATGCTCTTGC
TGTAGAGAGCAGCTGCTTCTGCCAGGGTGTTGGAGGTGGTGGAGCGCCTTCCGATTCCATTCATGGCATTTTGTGATGTGATGTAATTGG
AATAGAGCTGTTGATTTAAGGCACACACAATCCCTCACACTGTGGGTTTTTTTTAGAACTTCCCAGACGAAAACTCACGCCCTTGCCCTA
ACGCGCTTTGCTGTGAGCCTGGCCCCTGCCCAGGGCTTGGGTCTGGTGAGCTGAGCAGCTTCCTGTGGATGGTGTGGGGCCGGCCTCTGG
CCTGGCTCACCTGGCCACTGTCCAGCCAGCCTTGTGACAGACTCCGGCCTGAAGGCAGAATGAACCCACACCTGGAGTGAGGAAGGGGGC
CTGGCACGGTTGGCCAGGCTCTGCCTGATTGCCAGCCAGCGGGCATCTGAAGCCGGGTCCTTCGCCCGCCGGAGGCTGCCGTCCGTCTCT
CCTGCTGCGCTCGTGCCAGCTCCGTGGGTGTCCTCCCAGGGAGCTTCTCTTCTCAACAGGCCTTGCGAGGCTGGGGTGAGAGGTGATAGA
GGCAGCACTGTGCATGATTCCGAGAGGGTGTGGTGGCACTGCCAGCCGACTGCTGACAGCTTGGGAGCTGCTGTGCCCAGGACGTGGGTT
CAGCGTGGGCGAGGAAAGCCTGGCGAGCGTGGCCCTGTAAAAGCTTTCTGAGGCGGGAGGCGCTCACTTACCTCTGACTGCCTGGGCGCT
GCGTGTAGCATCTTGGCCTACAGGACAGATTTTAGGTGACACCTGGTTATGACAGTCAGAAATTTGAGAAGCTTCTCACAAGTGATGCAC
TTTAAATAATCTGCATGCCATTGAGACACCTGCATGTCTGGTGTTTGTGGTTCAAGTGTCTTGCCGCCGGCCTTCGGATGTAAACCCACT
GATAACGGACAGAAAGAGAATGCCCACAAGTGGGTCTTCTGTGGAAGATGCAGAAGGAGGAAGTTAGTGCTTACATTTTAGTCTTTTTCT
CCCTCAAAAAAATAGGTTAAGTTTCAGTGCCAGCTAGAAAATACTGCTTTCTGCCATCGATTGGGGGTGGTTTTTGTCAAATATACTGTT

>5234_5234_3_AP2A2-TOLLIP_AP2A2_chr11_926088_ENST00000534328_TOLLIP_chr11_1298483_ENST00000542915_length(amino acids)=203AA_BP=0
MGGEPPPRPGPPGTENPHAPKNRCGRGGTEVHGRGRHGCSFTGILLGQHSLGSAGSACPKSGGKTASRQRLYGSSPICSRELMAASLFPR
WASSTERITSWSMLGNMSWMAFRSSSLQRGWAFTAAGGRATGTMPGLQTAGIQLRISEMKTARPRIPSPLDTAGIFRRSGAASAGGPGRR

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Fusion Gene PPI Analysis for AP2A2-TOLLIP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AP2A2-TOLLIP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AP2A2-TOLLIP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource