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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MDM1-INSR (FusionGDB2 ID:52380)

Fusion Gene Summary for MDM1-INSR

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM1-INSR
Fusion gene ID: 52380
HgeneTgene
Gene symbol

MDM1

INSR

Gene ID

56890

3643

Gene nameMdm1 nuclear proteininsulin receptor
Synonyms-CD220|HHF5
Cytomap

12q15

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear protein MDM1Mdm4, transformed 3T3 cell double minute 1, p53 binding proteinnuclear protein double minute 1insulin receptorIR
Modification date2020031320200313
UniProtAcc.

P06213

Ensembl transtripts involved in fusion geneENST00000540418, ENST00000303145, 
ENST00000411698, ENST00000393543, 
ENST00000430606, ENST00000545724, 
ENST00000302850, ENST00000341500, 
Fusion gene scores* DoF score11 X 10 X 5=55020 X 13 X 8=2080
# samples 1120
** MAII scorelog2(11/550*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/2080*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MDM1 [Title/Abstract] AND INSR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMDM1(68696400)-INSR(7152938), # samples:2
Anticipated loss of major functional domain due to fusion event.MDM1-INSR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MDM1-INSR seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneINSR

GO:0001934

positive regulation of protein phosphorylation

7556070

TgeneINSR

GO:0002092

positive regulation of receptor internalization

25401701

TgeneINSR

GO:0007186

G protein-coupled receptor signaling pathway

9092559

TgeneINSR

GO:0008284

positive regulation of cell proliferation

17925406

TgeneINSR

GO:0008286

insulin receptor signaling pathway

6849137|8440175|20455999

TgeneINSR

GO:0018108

peptidyl-tyrosine phosphorylation

8496180

TgeneINSR

GO:0032148

activation of protein kinase B activity

7556070

TgeneINSR

GO:0032869

cellular response to insulin stimulus

8440175

TgeneINSR

GO:0043410

positive regulation of MAPK cascade

20455999

TgeneINSR

GO:0045725

positive regulation of glycogen biosynthetic process

17925406

TgeneINSR

GO:0046326

positive regulation of glucose import

3518947

TgeneINSR

GO:0046777

protein autophosphorylation

6849137|8496180

TgeneINSR

GO:0060267

positive regulation of respiratory burst

9092559


check buttonFusion gene breakpoints across MDM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across INSR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HS-01AMDM1chr12

68696400

-INSRchr19

7152938

-


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Fusion Gene ORF analysis for MDM1-INSR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000540418ENST00000302850MDM1chr12

68696400

-INSRchr19

7152938

-
Frame-shiftENST00000540418ENST00000341500MDM1chr12

68696400

-INSRchr19

7152938

-
In-frameENST00000303145ENST00000302850MDM1chr12

68696400

-INSRchr19

7152938

-
In-frameENST00000303145ENST00000341500MDM1chr12

68696400

-INSRchr19

7152938

-
In-frameENST00000411698ENST00000302850MDM1chr12

68696400

-INSRchr19

7152938

-
In-frameENST00000411698ENST00000341500MDM1chr12

68696400

-INSRchr19

7152938

-
intron-3CDSENST00000393543ENST00000302850MDM1chr12

68696400

-INSRchr19

7152938

-
intron-3CDSENST00000393543ENST00000341500MDM1chr12

68696400

-INSRchr19

7152938

-
intron-3CDSENST00000430606ENST00000302850MDM1chr12

68696400

-INSRchr19

7152938

-
intron-3CDSENST00000430606ENST00000341500MDM1chr12

68696400

-INSRchr19

7152938

-
intron-3CDSENST00000545724ENST00000302850MDM1chr12

68696400

-INSRchr19

7152938

-
intron-3CDSENST00000545724ENST00000341500MDM1chr12

68696400

-INSRchr19

7152938

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000303145MDM1chr1268696400-ENST00000341500INSRchr197152938-894420598741421351
ENST00000303145MDM1chr1268696400-ENST00000302850INSRchr197152938-460820598741781363
ENST00000411698MDM1chr1268696400-ENST00000341500INSRchr197152938-879319084139911316
ENST00000411698MDM1chr1268696400-ENST00000302850INSRchr197152938-445719084140271328

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000303145ENST00000341500MDM1chr1268696400-INSRchr197152938-0.0001412720.99985874
ENST00000303145ENST00000302850MDM1chr1268696400-INSRchr197152938-0.0002600450.99973994
ENST00000411698ENST00000341500MDM1chr1268696400-INSRchr197152938-0.0001277060.9998723
ENST00000411698ENST00000302850MDM1chr1268696400-INSRchr197152938-0.0002244250.9997756

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Fusion Genomic Features for MDM1-INSR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MDM1-INSR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:68696400/chr19:7152938)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.INSR

P06213

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneINSRchr12:68696400chr19:7152938ENST000003028508221023_12986761383.0DomainProtein kinase
TgeneINSRchr12:68696400chr19:7152938ENST00000302850822757_8426761383.0DomainFibronectin type-III 2
TgeneINSRchr12:68696400chr19:7152938ENST00000302850822853_9476761383.0DomainFibronectin type-III 3
TgeneINSRchr12:68696400chr19:7152938ENST000003415008211023_12986761371.0DomainProtein kinase
TgeneINSRchr12:68696400chr19:7152938ENST00000341500821757_8426761371.0DomainFibronectin type-III 2
TgeneINSRchr12:68696400chr19:7152938ENST00000341500821853_9476761371.0DomainFibronectin type-III 3
TgeneINSRchr12:68696400chr19:7152938ENST000003028508221104_11106761383.0Nucleotide bindingATP
TgeneINSRchr12:68696400chr19:7152938ENST000003028508221163_11646761383.0Nucleotide bindingATP
TgeneINSRchr12:68696400chr19:7152938ENST000003415008211104_11106761371.0Nucleotide bindingATP
TgeneINSRchr12:68696400chr19:7152938ENST000003415008211163_11646761371.0Nucleotide bindingATP
TgeneINSRchr12:68696400chr19:7152938ENST000003028508221361_13646761383.0RegionNote=PIK3R1-binding
TgeneINSRchr12:68696400chr19:7152938ENST00000302850822733_7416761383.0RegionNote=Insulin-binding
TgeneINSRchr12:68696400chr19:7152938ENST000003415008211361_13646761371.0RegionNote=PIK3R1-binding
TgeneINSRchr12:68696400chr19:7152938ENST00000341500821733_7416761371.0RegionNote=Insulin-binding
TgeneINSRchr12:68696400chr19:7152938ENST00000302850822763_9566761383.0Topological domainExtracellular
TgeneINSRchr12:68696400chr19:7152938ENST00000302850822980_13826761383.0Topological domainCytoplasmic
TgeneINSRchr12:68696400chr19:7152938ENST00000341500821763_9566761371.0Topological domainExtracellular
TgeneINSRchr12:68696400chr19:7152938ENST00000341500821980_13826761371.0Topological domainCytoplasmic
TgeneINSRchr12:68696400chr19:7152938ENST00000302850822957_9796761383.0TransmembraneHelical
TgeneINSRchr12:68696400chr19:7152938ENST00000341500821957_9796761371.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneINSRchr12:68696400chr19:7152938ENST00000302850822182_3396761383.0Compositional biasNote=Cys-rich
TgeneINSRchr12:68696400chr19:7152938ENST0000030285082228_1746761383.0Compositional biasNote=Leu-rich
TgeneINSRchr12:68696400chr19:7152938ENST00000341500821182_3396761371.0Compositional biasNote=Cys-rich
TgeneINSRchr12:68696400chr19:7152938ENST0000034150082128_1746761371.0Compositional biasNote=Leu-rich
TgeneINSRchr12:68696400chr19:7152938ENST00000302850822624_7266761383.0DomainFibronectin type-III 1
TgeneINSRchr12:68696400chr19:7152938ENST00000341500821624_7266761371.0DomainFibronectin type-III 1
TgeneINSRchr12:68696400chr19:7152938ENST0000030285082228_7586761383.0Topological domainExtracellular
TgeneINSRchr12:68696400chr19:7152938ENST0000034150082128_7586761371.0Topological domainExtracellular


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Fusion Gene Sequence for MDM1-INSR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52380_52380_1_MDM1-INSR_MDM1_chr12_68696400_ENST00000303145_INSR_chr19_7152938_ENST00000302850_length(transcript)=4608nt_BP=2059nt
GCTAGGGAACACTGTTATCGCCCCGCCCCCTCGGAGCTTTTTCTCCAGTTAACTGTCGGAGTAGCGGGGGCTCCGGCGCCGGGCGACATG
CCGGTGCGCTTCAAGGGGCTGAGTGAATACCAGAGGAACTTCCTGTGGAAAAAGTCTTATTTGTCCGAGTCTTGTAATTCCTCCGTGGGG
CGAAAGTACCCATGGGCTGGACTTAGATCAGATCAATTAGGCATCACGAAAGAGCCAAGTTTTATTTCAAAAAGAAGAGTCCCTTACCAT
GACCCACAGATTTCAAAATCTCTGGAGTGGAATGGAGCTATCTCAGAGAGCAATGTGGTTGCATCACCAGAACCAGAAGCCCCGGAAACA
CCAAAATCACAAGAAGCAGAACAAAAGGATGTTACTCAAGAAAGAGTTCACTCACTAGAAGCTTCCAGGGTTCCCAAAAGAACCAGATCT
CACTCTGCAGACTCCAGAGCTGAAGGGGCTTCAGATGTGGAAAATAATGAGGGTGTAACAAACCATACACCAGTTAATGAAAATGTGGAA
CTGGAACATTCTACCAAGGTTCTTTCAGAAAATGTAGATAATGGGTTGGATAGACTTCTGCGTAAGAAAGCTGGATTGACTGTTGTTCCT
TCATATAATGCCTTGAGAAATTCTGAATATCAAAGGCAGTTTGTTTGGAAGACTTCTAAAGAAACTGCTCCAGCTTTTGCAGCCAATCAG
GTTTTCCACAATAAAAGCCAGTTTGTTCCACCATTCAAAGGTAACTCAGTCATCCATGAAACTGAATACAAAAGAAATTTCAAGGGTTTA
TCTCCAGTGAAAGAACCAAAATTAAGAAATGATTTGAGAGAAAACAGAAATCTTGAAACAGTGTCTCCTGAAAGGAAGAGTAATAAAATA
GACGATCGTTTAAAATTGGAAGCAGAGATGGAATTAAAAGACTTACACCAGCCTAAAAGGAAGCTTACTCCTTGGAAACATCAAAGGCTT
GGGAAGGTGAATTCCGAATATAGAGCAAAATTTCTGAGCCCAGCTCAGTATTTATATAAAGCTGGGGCTTGGACACATGTAAAGGGAAAC
ATGCCAAATCAGGTTAAAGAACTCCGAGAAAAGGCTGAGTTTTATAGGAAGCGAGTTCAGGGGACGCATTTTTCTCGGGACCATCTGAAT
CAGATTTTATCTGATAGCAACTGCTGTTGGGATGTCTCCTCAACCACAAGCTCAGAAGGAACCGTTAGTAGCAACATCAGAGCATTAGAT
CTTGCTGGAGATCCTACAAGCCATAAGACTTTGCAGAAATGTCCTTCTACAGAACCAGAAGAAAAAGGAAATATCGTGGAAGAACAGCCC
CAGAAAAATACCACGGAGAAATTGGGTGTGTCAGCTCCCACCATACCCGTTAGAAGGCGGCTGGCTTGGGATACAGAGAACACAAGTGAA
GACGTACAGAAACAGCCCGGGGAGAAAGAGGAGGAGGACGACAATGAAGAGGAAGGGGACAGGAAAACGGGCAAGCAGGCTTTTATGGGA
GAGCAAGAGAAGTTGGATGTACGTGAGAAATCTAAGGCAGATAAGATGAAAGAAGGGTCAGATTCTTCTGTATCCTCAGAAAAAGGAGGC
CGGCTTCCTACTCCCAAGCTGAGAGAACTTGGTGGAATCCAGAGGACTCATCATGATCTCACTACTCCAGCTGTTGGTGGTGCTGTTTTA
GTGTCTCCATCTAAGATGAAGCCTCCAGCCCCAGAACAGAGGAAAAGAATGACCTCTCAGGATTGTTTAGAAACTTCAAAGAATGATTTT
ACTAAGAAAGAAAGTCGTGCTGTATCCCTACTGACTTCTCCAGCTGCTGGTATAAAAACAGTTGATCCTCTGCCTTTGCGGGAAGATTCT
GAAGACAATATCCACAAATTTGCTGAGGCAACTCTTCCAGTTTCAAAAATTCCAAAATACCCAACAAATCCCCCTGGACAGTTGCCTTCT
CCACCACATGTTCCATCCTACTGGCATCCCTCTCGACGAATTCAGGGCTCTCTTAGAGATCCAGAGTTTCAGCACAATGGGCTGAAGCTG
CCCTCGAGGACCTGGTCTCCACCATTCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGC
TCCTGTCCAAAGACAGACTCTCAGATCCTGAAGGAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTT
TTCGTCCCCAGAAAAACCTCTTCAGGCACTGGTGCCGAGGACCCTAGGCCATCTCGGAAACGCAGGTCCCTTGGCGATGTTGGGAATGTG
ACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCCTCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTTGAGAAG
GTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCATCGAGCTGCAGGCTTGCAACCAGGACACCCCT
GAGGAACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCCTGTGACGCATGAA
ATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTGAGTTATCGGCGA
TATGGTGATGAGGAGCTGCATCTCTGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAAC
TACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTC
CCGTCAAATATTGCAAAAATTATCATCGGCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGA
AAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTG
TACGTGCCGGACGAGTGGGAGGTGTCTCGAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGC
AATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAG
TTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTG
GTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCC
CCTACCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTG
GCAGCGAGAAACTGCATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTAC
CGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGG
TCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATG
GATGGAGGGTATCTGGATCAACCCGACAACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGG
CCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAG
GCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCG
GGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAAC
GGGCGGATTCTGACCTTGCCTCGGTCCAATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTC
TGGTTTGAAAGCCTCTGGAAAACTCAGGATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCAT
CTTAAGGTGGACTCGTTTGGTTACCAATTTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCT
GCTCCTTTGGGGCAACGACGGTTTCAAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTG
TTTTTACAAATTCTTTTTTTTTTTTTTTTTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAGACAAAACTTCCTGTTTGTGGAACAAAAGT

>52380_52380_1_MDM1-INSR_MDM1_chr12_68696400_ENST00000303145_INSR_chr19_7152938_ENST00000302850_length(amino acids)=1363AA_BP=657
MPVRFKGLSEYQRNFLWKKSYLSESCNSSVGRKYPWAGLRSDQLGITKEPSFISKRRVPYHDPQISKSLEWNGAISESNVVASPEPEAPE
TPKSQEAEQKDVTQERVHSLEASRVPKRTRSHSADSRAEGASDVENNEGVTNHTPVNENVELEHSTKVLSENVDNGLDRLLRKKAGLTVV
PSYNALRNSEYQRQFVWKTSKETAPAFAANQVFHNKSQFVPPFKGNSVIHETEYKRNFKGLSPVKEPKLRNDLRENRNLETVSPERKSNK
IDDRLKLEAEMELKDLHQPKRKLTPWKHQRLGKVNSEYRAKFLSPAQYLYKAGAWTHVKGNMPNQVKELREKAEFYRKRVQGTHFSRDHL
NQILSDSNCCWDVSSTTSSEGTVSSNIRALDLAGDPTSHKTLQKCPSTEPEEKGNIVEEQPQKNTTEKLGVSAPTIPVRRRLAWDTENTS
EDVQKQPGEKEEEDDNEEEGDRKTGKQAFMGEQEKLDVREKSKADKMKEGSDSSVSSEKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAV
LVSPSKMKPPAPEQRKRMTSQDCLETSKNDFTKKESRAVSLLTSPAAGIKTVDPLPLREDSEDNIHKFAEATLPVSKIPKYPTNPPGQLP
SPPHVPSYWHPSRRIQGSLRDPEFQHNGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNV
VFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDT
PEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPG
NYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCS
VYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPT
LVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY
YRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKM
RPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKK

--------------------------------------------------------------
>52380_52380_2_MDM1-INSR_MDM1_chr12_68696400_ENST00000303145_INSR_chr19_7152938_ENST00000341500_length(transcript)=8944nt_BP=2059nt
GCTAGGGAACACTGTTATCGCCCCGCCCCCTCGGAGCTTTTTCTCCAGTTAACTGTCGGAGTAGCGGGGGCTCCGGCGCCGGGCGACATG
CCGGTGCGCTTCAAGGGGCTGAGTGAATACCAGAGGAACTTCCTGTGGAAAAAGTCTTATTTGTCCGAGTCTTGTAATTCCTCCGTGGGG
CGAAAGTACCCATGGGCTGGACTTAGATCAGATCAATTAGGCATCACGAAAGAGCCAAGTTTTATTTCAAAAAGAAGAGTCCCTTACCAT
GACCCACAGATTTCAAAATCTCTGGAGTGGAATGGAGCTATCTCAGAGAGCAATGTGGTTGCATCACCAGAACCAGAAGCCCCGGAAACA
CCAAAATCACAAGAAGCAGAACAAAAGGATGTTACTCAAGAAAGAGTTCACTCACTAGAAGCTTCCAGGGTTCCCAAAAGAACCAGATCT
CACTCTGCAGACTCCAGAGCTGAAGGGGCTTCAGATGTGGAAAATAATGAGGGTGTAACAAACCATACACCAGTTAATGAAAATGTGGAA
CTGGAACATTCTACCAAGGTTCTTTCAGAAAATGTAGATAATGGGTTGGATAGACTTCTGCGTAAGAAAGCTGGATTGACTGTTGTTCCT
TCATATAATGCCTTGAGAAATTCTGAATATCAAAGGCAGTTTGTTTGGAAGACTTCTAAAGAAACTGCTCCAGCTTTTGCAGCCAATCAG
GTTTTCCACAATAAAAGCCAGTTTGTTCCACCATTCAAAGGTAACTCAGTCATCCATGAAACTGAATACAAAAGAAATTTCAAGGGTTTA
TCTCCAGTGAAAGAACCAAAATTAAGAAATGATTTGAGAGAAAACAGAAATCTTGAAACAGTGTCTCCTGAAAGGAAGAGTAATAAAATA
GACGATCGTTTAAAATTGGAAGCAGAGATGGAATTAAAAGACTTACACCAGCCTAAAAGGAAGCTTACTCCTTGGAAACATCAAAGGCTT
GGGAAGGTGAATTCCGAATATAGAGCAAAATTTCTGAGCCCAGCTCAGTATTTATATAAAGCTGGGGCTTGGACACATGTAAAGGGAAAC
ATGCCAAATCAGGTTAAAGAACTCCGAGAAAAGGCTGAGTTTTATAGGAAGCGAGTTCAGGGGACGCATTTTTCTCGGGACCATCTGAAT
CAGATTTTATCTGATAGCAACTGCTGTTGGGATGTCTCCTCAACCACAAGCTCAGAAGGAACCGTTAGTAGCAACATCAGAGCATTAGAT
CTTGCTGGAGATCCTACAAGCCATAAGACTTTGCAGAAATGTCCTTCTACAGAACCAGAAGAAAAAGGAAATATCGTGGAAGAACAGCCC
CAGAAAAATACCACGGAGAAATTGGGTGTGTCAGCTCCCACCATACCCGTTAGAAGGCGGCTGGCTTGGGATACAGAGAACACAAGTGAA
GACGTACAGAAACAGCCCGGGGAGAAAGAGGAGGAGGACGACAATGAAGAGGAAGGGGACAGGAAAACGGGCAAGCAGGCTTTTATGGGA
GAGCAAGAGAAGTTGGATGTACGTGAGAAATCTAAGGCAGATAAGATGAAAGAAGGGTCAGATTCTTCTGTATCCTCAGAAAAAGGAGGC
CGGCTTCCTACTCCCAAGCTGAGAGAACTTGGTGGAATCCAGAGGACTCATCATGATCTCACTACTCCAGCTGTTGGTGGTGCTGTTTTA
GTGTCTCCATCTAAGATGAAGCCTCCAGCCCCAGAACAGAGGAAAAGAATGACCTCTCAGGATTGTTTAGAAACTTCAAAGAATGATTTT
ACTAAGAAAGAAAGTCGTGCTGTATCCCTACTGACTTCTCCAGCTGCTGGTATAAAAACAGTTGATCCTCTGCCTTTGCGGGAAGATTCT
GAAGACAATATCCACAAATTTGCTGAGGCAACTCTTCCAGTTTCAAAAATTCCAAAATACCCAACAAATCCCCCTGGACAGTTGCCTTCT
CCACCACATGTTCCATCCTACTGGCATCCCTCTCGACGAATTCAGGGCTCTCTTAGAGATCCAGAGTTTCAGCACAATGGGCTGAAGCTG
CCCTCGAGGACCTGGTCTCCACCATTCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGC
TCCTGTCCAAAGACAGACTCTCAGATCCTGAAGGAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTT
TTCGTCCCCAGGCCATCTCGGAAACGCAGGTCCCTTGGCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAAC
ACTTCCTCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTG
CGACACTTCACGGGCTATCGCATCGAGCTGCAGGCTTGCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTCAGTGCG
AGGACCATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCCTGTGACGCATGAAATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAG
GAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTCTCCCGC
AAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGC
AACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGCCCCCTC
ATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTAC
GCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGAGAGAAG
ATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACC
CGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACC
TGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAG
AGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCGGCAGAG
ATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATGATTTTACT
GTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGGTGG
ATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTG
GCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAACTGTCCA
GAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGAC
GACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTTGAG
GACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAG
CGGAGCTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAATCCTTCC
TAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGGATTCTCAC
GACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAATTTAACTAG
TCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAACCAGGATT
TTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTTTTTTTTGC
TGGTGTCTGAGCTTCAGTATAAAAGACAAAACTTCCTGTTTGTGGAACAAAAGTTCGAAAGAAAAAACAAAACAAAAACACCCAGCCCTG
TTCCAGGAGAATTTCAAGTTTTACAGGTTGAGCTTCAAGATGGTTTTTTTGGTTTTTTTTTTTTCTCTCATCCAGGCTGAAGGATTTTTT
TTTTCTTTACAAAATGAGTTCCTCAAATTGACCAATAGCTGCTGCTTTCATATTTTGGATAAGGGTCTGTGGTCCCGGCGTGTGCTCACG
TGTGTATGCACGTGTGTGTGTCCATTAGACACGGCTGATGTGTGTGCAAAGTATCCATGCGGAGTTGATGCTTTGGGAATTGGCTCATGA
AGGTTCTTCTCAAGGGTGCGAGCTCATCCCCCTCTCTCCTTCCTTCTTATTGACTGGGAGACTGTGCTCTCGACAGATTCTTCTTGTGTC
AGAAGTCTAGCCTCAGGTTTCTACCCTCCCTTCACATTGGTGGCCAAGGGAGGAGCATTTCATTTGGAGTGATTATGAATCTTTTCAAGA
CCAAACCAAGCTAGGACATTAAAAAAAAAAAAAGAAAAAGAAAGAAAAAACAAAATGGAAAAAGGAAAAAAAAAAAGAACTGAGATGACA
GAGTTTTGAGAATATATTTGTACCATATTTAATTTTTAAAGTCTCTGGTATTAGCCTCATAAGTTATTGACTATTCCCCGGGGTTGGCGG
GGAGTGGGGACATGAGTTGGTCTGCCTGTTGTGGGGCCGGGAAGGGGAGGGAGTCAGGCACAAGTGGCCTCTTTGTTTGGTCTTAAAGGC
ATCCATTTCTGGGAATGAAGCCATGTTCGCTGCTAACACTTTTGGATGTTGTGAGGCCACGTGGAGTGTGTGAGAGACTAGGTTTTATGG
ATGGTCTGGTTCAGGTACCAGGTCTGCTGGAAGGTTCCTGTTCGGATAAGCTGGTAGCTACCTAGCTCTGAGCCTGCCTTCAAGAACACC
TGTGTTCATCCTCTGATTCTCTGTGTGTACCTCTTGTGGCGTTTCCTCTCCCGGGTGTGAACATCCTAACCGTTATTGTGCAAACCCAAG
AACGTCAGATCCCAAAGCACAACAACCTGGATGGACTTTGGGAACATCTAAGCAATGTAAGAGAGAGGTGCACTGAGAGTACGTCTTGGT
CCCCTCCACCCTGAGAGCATCTGACGGTCCTCAGTACTGAACTCCCGGAAGCTGCTCTGAGCCCGGTGACCTCATCTGGGCCAGGTGTGG
TGCCTGAGCTGAATGCTCAGGTGCTTACAGTGTTGCAATCCCTAAGAGAGTAGAGTCTGGAGGAGAAACCGTGAAAAAGACCTTACACAC
CACCAAGAACTTCCGAATGGGCGTGAATCCACCGTTTCTTCTCTTTGCAAAAAGAACCACCACAGCTGCTCAAAGAACACAGTGAACTCA
TCACTTTGGTTCATCAAAAAATCATCGCCCATGCGTTATTCCTGAGTGCATTTTCTTACAACTTTTTGACTGCTTCCTTTTCTTCTTCTC
TTAAGAGTTGTGGGCTTAAGAATGGGATAGAGTCATAATGGCAACCTCCAAGCCCTCTCAATTCTTGATTAAGAACACAGGTAGACATGA
ATCCCAATTGTCTATTGCTATCTTATTTATATGATTCGGGAAAATACAGCATGTAAAAATATTGCTGAGGAGCCTCAGTGATTGGGTACA
AGAAGCAAGAGTACAGAAATTATTTTTGCCAAATTTATTTTGTAAATATGAGGGTCTGTACCTAAATTTAAAAAAAAAACACGTAGAACT
AGGTATTTTGTTCTCTTCTTAGTAAATTTGTAGTGGTTGTATACTACACTAGCTGCAATTTTCACATTTTTCTAATTCAGAAAGGTTTTT
CTTATATTAGGGGAAAAAGTATTTATTTTAATATATAAAATCACTCTGAAAATCACTCTCATAAAAAATGGAGCGCATGTAAATTTTTAT
CAAAGAAAAATAAACAGGTGAATGGGGGATAGTGATTTTCTTTTTTCAGCACAGTCTACCTCAGTGTATTGTTAAGATGTGATTCAATCA
TGGACATCTTTGAGATTTCAGAATTCTACCTGGAACCGGTCTGAATCAGGGAACGTGTGTATCAGCTGATTCGAATGCCAGGGACCAGTA
AGAATTTTGAGGGAGGGAGTTGGGATGGAGAAGGTATGGCCTTTATGCGAGCATAGATCCTTTTCTTCCTGGCTGGTAATATTCTTCTCT
GAATTTAATCTTCCTTTAAAAAAAAATCCTCCATCTATTGTCACTATGTTCCCCAAACATAAACTAAGTTCCAGGCTGTCATGATGTATC
TGATATATGGGGTAACCCAGCAAGGTGTACCTTCCTTTGGTGAGAGATGGCTGCCGGGGCAAAGACGGGCTTTGATTCAGAGCAAGCATT
CCCACCTGTTCCATGGAATCCCCCTGAAGTGAGCACAAAGGTGCCCTGGGCTCCCTGATGGTTTATGCCCACTCCTTTCAGGCTGGTGAT
GCACCTTACACACAAACACCTAATGCAATGTCTTTTTAAATTCTCCAAGTGGGATGGGAGCATGTGAGGGAAATTCCAATCCAAAACCCA
TTAATGTGCTGAACGCTTTTTTTTTTTTTTTTTTTTTTTTTGCAACAACACCTTGGACCTCTGTGTTGGGGTTTGACTGACCTCAAGCTG
ATATTATTGGACCTTGTGCAGCTTTGATAACCCATGTGAGAGTCTAGGCAGGACCAGTGGGGCCCAAATCTTGCTGCTCTTGTACTTTTA
GGCACTGCCCTTGCAGACTCACCTTTCTCCACCTGCCCTGGAGAAAGGTAGGGTGTGCTGGGCCTGCCCCTTGCAAATGGGATTCACCAG
TTTCATTTATTTGACTCTACTGCCACAGTGAAAAGAGCAAACAGCTATTGGGTTGCAAACCTCCTTTGACATTAGGAAATGTTGACTTTG
TAACAATAAAACTTTGGTCCTAGAAAGACACGGTTGTCCTGGGAGTTTGTAGTGTTAAGTTGCAACAACAACAACAAAAAGCAACAAAAC
CAGCTTAGGATAACACTTTTTGTTGCTTGTTCTTAAAGATGTCTCACTATGATTAAAACCCTTTTCATTAATGTAGTGAAAGCCACACAG
GAGTTCCTTCTTCCAGGAGGAGAATACCAAGCACATCACTTTCTCTCTGCATCAGTGATGTCAAATACGCATCAGAAAATGTTCAGGTTT
TAGGAGCTGTCCTAGGTGCTGTTTCATCATTGGAAGCAGTGAGAAAGAGAAGCACTGCTGCTTGTCTGGATATAGGCTGAGGATGATTGA
GAGAAGCTGTGGGAACTGACACAAGGGTCTGCATAGGTCATCCTGTGACCCTGGGGACTATGTTACCAACTGACAGACAGATCTTTCACT
GTATCCTAGCAGGGCAGGTAGTCCACCAAGAAATGTGCTTATTGGATTGGGAGGTGTTTATTTGTAGTCTGCTGTAACACGTGTGAAAGA
GCAGGAGCGTCATCAGCATATGACTTGCGCTGGTCATCCGGTAAATGGATGTGCTGTAGTCCCAGTGCTAATCATTTCTCTCCTTCACAG
TGGGTGGAAGTTTAGGGTTAAATGTCCTTTGAATGTCACCTGGTGAGTCCTTGACACCTTAGGCTCTTCAGAAACAATGGTTTTGTTGAG
GATGGGGAACAGGGAATGCCGATTTTATATACATGGTACACAGAGAGGGGTGTCACTTCAGAAAATCTTCCAGCATGTTCTTCAGAATAT
TAATTTATATGCGAGGTGAGGTTGGGAATGAAAAGAACAGGTCAGCACTTTTTTTTTTCCTAGAACATACAAAAGAACATGGTGGACTTT
CAGGGAGTGCAATGGAAGGTGAATATTTCCTTAAGGGTCCCCGAGAAATGGGAGTGAGGGGAGGGGACACAATGGCTTTTTGAGCTTACT
TTTACCTTCTGATACTAGTCAAGGTCCAGAACCAGCCACCAGCCAAATTTCTATCTGGGTGCGGGCCACTGAAAATCCTTGTTAAAAACC
AGATCACAAATCTGGGGCTCTTGGTCCCATTGGAGAAGGAAGGAAGAGCCTCAAAATAAGTGTGCACCCATGCACATATTCAGGAACAGC
TTGTTTAGTCTTTACACTTTGCCTGAAAGTTGCTTCTCCTCGTCCCTTTGTGTGCCTGGGTGGCCTCGGCCCTGTGCGTTGGCAACGCAG
GATCAAATGTGCTGCAGCTTTTGCAGAAAACAACTCAGAAACACAAAACCCCCCAACAGCTCAATTATTATTTTTTCAATGTTTTCCTAC
AAGAGCCAAGTAGCACCATGTACAGAAGACGCCTTTTTTTTTGGAATATTGAAATCGTTCTGCATGTAAAATATGGGATAATGACCTGTT

>52380_52380_2_MDM1-INSR_MDM1_chr12_68696400_ENST00000303145_INSR_chr19_7152938_ENST00000341500_length(amino acids)=1351AA_BP=657
MPVRFKGLSEYQRNFLWKKSYLSESCNSSVGRKYPWAGLRSDQLGITKEPSFISKRRVPYHDPQISKSLEWNGAISESNVVASPEPEAPE
TPKSQEAEQKDVTQERVHSLEASRVPKRTRSHSADSRAEGASDVENNEGVTNHTPVNENVELEHSTKVLSENVDNGLDRLLRKKAGLTVV
PSYNALRNSEYQRQFVWKTSKETAPAFAANQVFHNKSQFVPPFKGNSVIHETEYKRNFKGLSPVKEPKLRNDLRENRNLETVSPERKSNK
IDDRLKLEAEMELKDLHQPKRKLTPWKHQRLGKVNSEYRAKFLSPAQYLYKAGAWTHVKGNMPNQVKELREKAEFYRKRVQGTHFSRDHL
NQILSDSNCCWDVSSTTSSEGTVSSNIRALDLAGDPTSHKTLQKCPSTEPEEKGNIVEEQPQKNTTEKLGVSAPTIPVRRRLAWDTENTS
EDVQKQPGEKEEEDDNEEEGDRKTGKQAFMGEQEKLDVREKSKADKMKEGSDSSVSSEKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAV
LVSPSKMKPPAPEQRKRMTSQDCLETSKNDFTKKESRAVSLLTSPAAGIKTVDPLPLREDSEDNIHKFAEATLPVSKIPKYPTNPPGQLP
SPPHVPSYWHPSRRIQGSLRDPEFQHNGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNV
VFVPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVS
ARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLA
GNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSRE
KITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDL
KSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR
WMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK
DDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNP

--------------------------------------------------------------
>52380_52380_3_MDM1-INSR_MDM1_chr12_68696400_ENST00000411698_INSR_chr19_7152938_ENST00000302850_length(transcript)=4457nt_BP=1908nt
AGTTAACTGTCGGAGTAGCGGGGGCTCCGGCGCCGGGCGACATGCCGGTGCGCTTCAAGGGGCTGAGTGAATACCAGAGGAACTTCCTGT
GGAAAAAGTCTTATTTGTCCGAGTCTTGTAATTCCTCCGTGGGGCGAAAGTACCCATGGGCTGGACTTAGATCAGATCAATTAGGCATCA
CGAAAGAGCCAAGTTTTATTTCAAAAAGAAGAGTCCCTTACCATGACCCACAGATTTCAAAATCTCTGGAGTGGAATGGAGCTATCTCAG
AGAGCAATGTGGTTGCATCACCAGAACCAGAAGCCCCGGAAACACCAAAATCACAAGAAGCAGAACAAAAGGATGTTACTCAAGAAAGAG
TTCACTCACTAGAAGCTTCCAGGGTTCCCAAAAGAACCAGATCTCACTCTGCAGACTCCAGAGCTGAAGGGGCTTCAGATGTGGAAAATA
ATGAGGGTGTAACAAACCATACACCAGTTAATGAAAATGTGGAACTGGAACATTCTACCAAGGTTCTTTCAGAAAATGTAGATAATGGGG
TTTTCCACAATAAAAGCCAGTTTGTTCCACCATTCAAAGGTAACTCAGTCATCCATGAAACTGAATACAAAAGAAATTTCAAGGGTTTAT
CTCCAGTGAAAGAACCAAAATTAAGAAATGATTTGAGAGAAAACAGAAATCTTGAAACAGTGTCTCCTGAAAGGAAGAGTAATAAAATAG
ACGATCGTTTAAAATTGGAAGCAGAGATGGAATTAAAAGACTTACACCAGCCTAAAAGGAAGCTTACTCCTTGGAAACATCAAAGGCTTG
GGAAGGTGAATTCCGAATATAGAGCAAAATTTCTGAGCCCAGCTCAGTATTTATATAAAGCTGGGGCTTGGACACATGTAAAGGGAAACA
TGCCAAATCAGGGTTCTCTAAATGCCATGTGGTATGCTGAGGTTAAAGAACTCCGAGAAAAGGCTGAGTTTTATAGGAAGCGAGTTCAGG
GGACGCATTTTTCTCGGGACCATCTGAATCAGATTTTATCTGATAGCAACTGCTGTTGGGATGTCTCCTCAACCACAAGCTCAGAAGGAA
CCGTTAGTAGCAACATCAGAGCATTAGATCTTGCTGGAGATCCTACAAGCCATAAGACTTTGCAGAAATGTCCTTCTACAGAACCAGAAG
AAAAAGGAAATATCGTGGAAGAACAGCCCCAGAAAAATACCACGGAGAAATTGGGTGTGTCAGCTCCCACCATACCCGTTAGAAGGCGGC
TGGCTTGGGATACAGAGAACACAAGTGAAGACGTACAGAAACAGCCCGGGGAGAAAGAGGAGGAGGACGACAATGAAGAGGAAGGGGACA
GGAAAACGGGCAAGCAGGCTTTTATGGGAGAGCAAGAGAAGTTGGATGTACGTGAGAAATCTAAGGCAGATAAGATGAAAGAAGGGTCAG
ATTCTTCTGTATCCTCAGAAAAAGGAGGCCGGCTTCCTACTCCCAAGCTGAGAGAACTTGGTGGAATCCAGAGGACTCATCATGATCTCA
CTACTCCAGCTGTTGGTGGTGCTGTTTTAGTGTCTCCATCTAAGATGAAGCCTCCAGCCCCAGAACAGAGGAAAAGAATGACCTCTCAGG
ATTGTTTAGAAACTTCAAAGAATGATTTTACTAAGAAAGAAAGTCGTGCTGTATCCCTACTGACTTCTCCAGCTGCTGGTATAAAAACAG
TTGATCCTCTGCCTTTGCGGGAAGATTCTGAAGACAATATCCACAAATTTGCTGAGGCAACTCTTCCAGTTTCAAAAATTCCAAAATACC
CAACAAATCCCCCTGGACAGTTGCCTTCTCCACCACATGTTCCATCCTACTGGCATCCCTCTCGACGAATTCAGGGCTCTCTTAGAGATC
CAGAGTTTCAGCACAATGGGCTGAAGCTGCCCTCGAGGACCTGGTCTCCACCATTCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGTG
AGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCCTGAAGGAGCTGGAGGAGTCCTCGTTTAGGAAGA
CGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGAAAAACCTCTTCAGGCACTGGTGCCGAGGACCCTAGGCCATCTCGGAAAC
GCAGGTCCCTTGGCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCCTCGACCAGCGTGCCCACGA
GTCCGGAGGAGCACAGGCCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCATCG
AGCTGCAGGCTTGCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTG
ATGACATTGTTGGCCCTGTGACGCATGAAATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGA
TCGTGCTGTATGAAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCT
GCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGCAACGGCTCTTGGACGGAACCCACCT
ATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTG
TGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAGTATCTCA
GTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGAGAGAAGATCACCCTCCTTCGAGAGCTGGGGC
AGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAACG
AGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCATCACGTGGTGCGCCTCCTGG
GAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAG
AGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGA
ACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGA
CCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATG
GGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTGT
CTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAACTGTCCAGAGAGAGTCACTGACCTCATGCGCA
TGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAGG
TGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTTGAGGACATGGAGAATGTGCCCCTGGACC
GTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAGCTACGAGGAACACATCCCTT
ACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAATCCTTCCTAACAGTGCCTACCGTGGCGGGGGC
GGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGGATTCTCACGACTCTACCATGTCCAATGGAGTTC
AGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAATTTAACTAGTCCTGCAGAGGATTTAACTGTGAAC
CTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCC
GCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTTTTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAG

>52380_52380_3_MDM1-INSR_MDM1_chr12_68696400_ENST00000411698_INSR_chr19_7152938_ENST00000302850_length(amino acids)=1328AA_BP=622
MPVRFKGLSEYQRNFLWKKSYLSESCNSSVGRKYPWAGLRSDQLGITKEPSFISKRRVPYHDPQISKSLEWNGAISESNVVASPEPEAPE
TPKSQEAEQKDVTQERVHSLEASRVPKRTRSHSADSRAEGASDVENNEGVTNHTPVNENVELEHSTKVLSENVDNGVFHNKSQFVPPFKG
NSVIHETEYKRNFKGLSPVKEPKLRNDLRENRNLETVSPERKSNKIDDRLKLEAEMELKDLHQPKRKLTPWKHQRLGKVNSEYRAKFLSP
AQYLYKAGAWTHVKGNMPNQGSLNAMWYAEVKELREKAEFYRKRVQGTHFSRDHLNQILSDSNCCWDVSSTTSSEGTVSSNIRALDLAGD
PTSHKTLQKCPSTEPEEKGNIVEEQPQKNTTEKLGVSAPTIPVRRRLAWDTENTSEDVQKQPGEKEEEDDNEEEGDRKTGKQAFMGEQEK
LDVREKSKADKMKEGSDSSVSSEKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAVLVSPSKMKPPAPEQRKRMTSQDCLETSKNDFTKKE
SRAVSLLTSPAAGIKTVDPLPLREDSEDNIHKFAEATLPVSKIPKYPTNPPGQLPSPPHVPSYWHPSRRIQGSLRDPEFQHNGLKLPSRT
WSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAV
PTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFEN
NVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNI
AKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARD
IIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQ
EMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGV
VLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPES

--------------------------------------------------------------
>52380_52380_4_MDM1-INSR_MDM1_chr12_68696400_ENST00000411698_INSR_chr19_7152938_ENST00000341500_length(transcript)=8793nt_BP=1908nt
AGTTAACTGTCGGAGTAGCGGGGGCTCCGGCGCCGGGCGACATGCCGGTGCGCTTCAAGGGGCTGAGTGAATACCAGAGGAACTTCCTGT
GGAAAAAGTCTTATTTGTCCGAGTCTTGTAATTCCTCCGTGGGGCGAAAGTACCCATGGGCTGGACTTAGATCAGATCAATTAGGCATCA
CGAAAGAGCCAAGTTTTATTTCAAAAAGAAGAGTCCCTTACCATGACCCACAGATTTCAAAATCTCTGGAGTGGAATGGAGCTATCTCAG
AGAGCAATGTGGTTGCATCACCAGAACCAGAAGCCCCGGAAACACCAAAATCACAAGAAGCAGAACAAAAGGATGTTACTCAAGAAAGAG
TTCACTCACTAGAAGCTTCCAGGGTTCCCAAAAGAACCAGATCTCACTCTGCAGACTCCAGAGCTGAAGGGGCTTCAGATGTGGAAAATA
ATGAGGGTGTAACAAACCATACACCAGTTAATGAAAATGTGGAACTGGAACATTCTACCAAGGTTCTTTCAGAAAATGTAGATAATGGGG
TTTTCCACAATAAAAGCCAGTTTGTTCCACCATTCAAAGGTAACTCAGTCATCCATGAAACTGAATACAAAAGAAATTTCAAGGGTTTAT
CTCCAGTGAAAGAACCAAAATTAAGAAATGATTTGAGAGAAAACAGAAATCTTGAAACAGTGTCTCCTGAAAGGAAGAGTAATAAAATAG
ACGATCGTTTAAAATTGGAAGCAGAGATGGAATTAAAAGACTTACACCAGCCTAAAAGGAAGCTTACTCCTTGGAAACATCAAAGGCTTG
GGAAGGTGAATTCCGAATATAGAGCAAAATTTCTGAGCCCAGCTCAGTATTTATATAAAGCTGGGGCTTGGACACATGTAAAGGGAAACA
TGCCAAATCAGGGTTCTCTAAATGCCATGTGGTATGCTGAGGTTAAAGAACTCCGAGAAAAGGCTGAGTTTTATAGGAAGCGAGTTCAGG
GGACGCATTTTTCTCGGGACCATCTGAATCAGATTTTATCTGATAGCAACTGCTGTTGGGATGTCTCCTCAACCACAAGCTCAGAAGGAA
CCGTTAGTAGCAACATCAGAGCATTAGATCTTGCTGGAGATCCTACAAGCCATAAGACTTTGCAGAAATGTCCTTCTACAGAACCAGAAG
AAAAAGGAAATATCGTGGAAGAACAGCCCCAGAAAAATACCACGGAGAAATTGGGTGTGTCAGCTCCCACCATACCCGTTAGAAGGCGGC
TGGCTTGGGATACAGAGAACACAAGTGAAGACGTACAGAAACAGCCCGGGGAGAAAGAGGAGGAGGACGACAATGAAGAGGAAGGGGACA
GGAAAACGGGCAAGCAGGCTTTTATGGGAGAGCAAGAGAAGTTGGATGTACGTGAGAAATCTAAGGCAGATAAGATGAAAGAAGGGTCAG
ATTCTTCTGTATCCTCAGAAAAAGGAGGCCGGCTTCCTACTCCCAAGCTGAGAGAACTTGGTGGAATCCAGAGGACTCATCATGATCTCA
CTACTCCAGCTGTTGGTGGTGCTGTTTTAGTGTCTCCATCTAAGATGAAGCCTCCAGCCCCAGAACAGAGGAAAAGAATGACCTCTCAGG
ATTGTTTAGAAACTTCAAAGAATGATTTTACTAAGAAAGAAAGTCGTGCTGTATCCCTACTGACTTCTCCAGCTGCTGGTATAAAAACAG
TTGATCCTCTGCCTTTGCGGGAAGATTCTGAAGACAATATCCACAAATTTGCTGAGGCAACTCTTCCAGTTTCAAAAATTCCAAAATACC
CAACAAATCCCCCTGGACAGTTGCCTTCTCCACCACATGTTCCATCCTACTGGCATCCCTCTCGACGAATTCAGGGCTCTCTTAGAGATC
CAGAGTTTCAGCACAATGGGCTGAAGCTGCCCTCGAGGACCTGGTCTCCACCATTCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGTG
AGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCCTGAAGGAGCTGGAGGAGTCCTCGTTTAGGAAGA
CGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGGCCATCTCGGAAACGCAGGTCCCTTGGCGATGTTGGGAATGTGACGGTGG
CCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCCTCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTTGAGAAGGTGGTGA
ACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCATCGAGCTGCAGGCTTGCAACCAGGACACCCCTGAGGAAC
GGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCCTGTGACGCATGAAATCTTTG
AGAACAACGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTGAGTTATCGGCGATATGGTG
ATGAGGAGCTGCATCTCTGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCG
TGCGAATCCGGGCCACCTCCCTTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAA
ATATTGCAAAAATTATCATCGGCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGC
AGCCAGATGGGCCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGC
CGGACGAGTGGGAGGTGTCTCGAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCA
GGGACATCATCAAGGGTGAGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCA
ATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGA
TGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCC
TTCAAGAGATGATTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGA
GAAACTGCATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAG
GGGGCAAGGGTCTGCTCCCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTG
GCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAG
GGTATCTGGATCAACCCGACAACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCT
TCCTGGAGATTGTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCG
AGAGTGAGGAGCTGGAGATGGAGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCC
GGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAACGGGCGGA
TTCTGACCTTGCCTCGGTCCAATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTG
AAAGCCTCTGGAAAACTCAGGATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCATCTTAAGG
TGGACTCGTTTGGTTACCAATTTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTT
TGGGGCAACGACGGTTTCAAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTAC
AAATTCTTTTTTTTTTTTTTTTTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAGACAAAACTTCCTGTTTGTGGAACAAAAGTTCGAAAG
AAAAAACAAAACAAAAACACCCAGCCCTGTTCCAGGAGAATTTCAAGTTTTACAGGTTGAGCTTCAAGATGGTTTTTTTGGTTTTTTTTT
TTTCTCTCATCCAGGCTGAAGGATTTTTTTTTTCTTTACAAAATGAGTTCCTCAAATTGACCAATAGCTGCTGCTTTCATATTTTGGATA
AGGGTCTGTGGTCCCGGCGTGTGCTCACGTGTGTATGCACGTGTGTGTGTCCATTAGACACGGCTGATGTGTGTGCAAAGTATCCATGCG
GAGTTGATGCTTTGGGAATTGGCTCATGAAGGTTCTTCTCAAGGGTGCGAGCTCATCCCCCTCTCTCCTTCCTTCTTATTGACTGGGAGA
CTGTGCTCTCGACAGATTCTTCTTGTGTCAGAAGTCTAGCCTCAGGTTTCTACCCTCCCTTCACATTGGTGGCCAAGGGAGGAGCATTTC
ATTTGGAGTGATTATGAATCTTTTCAAGACCAAACCAAGCTAGGACATTAAAAAAAAAAAAAGAAAAAGAAAGAAAAAACAAAATGGAAA
AAGGAAAAAAAAAAAGAACTGAGATGACAGAGTTTTGAGAATATATTTGTACCATATTTAATTTTTAAAGTCTCTGGTATTAGCCTCATA
AGTTATTGACTATTCCCCGGGGTTGGCGGGGAGTGGGGACATGAGTTGGTCTGCCTGTTGTGGGGCCGGGAAGGGGAGGGAGTCAGGCAC
AAGTGGCCTCTTTGTTTGGTCTTAAAGGCATCCATTTCTGGGAATGAAGCCATGTTCGCTGCTAACACTTTTGGATGTTGTGAGGCCACG
TGGAGTGTGTGAGAGACTAGGTTTTATGGATGGTCTGGTTCAGGTACCAGGTCTGCTGGAAGGTTCCTGTTCGGATAAGCTGGTAGCTAC
CTAGCTCTGAGCCTGCCTTCAAGAACACCTGTGTTCATCCTCTGATTCTCTGTGTGTACCTCTTGTGGCGTTTCCTCTCCCGGGTGTGAA
CATCCTAACCGTTATTGTGCAAACCCAAGAACGTCAGATCCCAAAGCACAACAACCTGGATGGACTTTGGGAACATCTAAGCAATGTAAG
AGAGAGGTGCACTGAGAGTACGTCTTGGTCCCCTCCACCCTGAGAGCATCTGACGGTCCTCAGTACTGAACTCCCGGAAGCTGCTCTGAG
CCCGGTGACCTCATCTGGGCCAGGTGTGGTGCCTGAGCTGAATGCTCAGGTGCTTACAGTGTTGCAATCCCTAAGAGAGTAGAGTCTGGA
GGAGAAACCGTGAAAAAGACCTTACACACCACCAAGAACTTCCGAATGGGCGTGAATCCACCGTTTCTTCTCTTTGCAAAAAGAACCACC
ACAGCTGCTCAAAGAACACAGTGAACTCATCACTTTGGTTCATCAAAAAATCATCGCCCATGCGTTATTCCTGAGTGCATTTTCTTACAA
CTTTTTGACTGCTTCCTTTTCTTCTTCTCTTAAGAGTTGTGGGCTTAAGAATGGGATAGAGTCATAATGGCAACCTCCAAGCCCTCTCAA
TTCTTGATTAAGAACACAGGTAGACATGAATCCCAATTGTCTATTGCTATCTTATTTATATGATTCGGGAAAATACAGCATGTAAAAATA
TTGCTGAGGAGCCTCAGTGATTGGGTACAAGAAGCAAGAGTACAGAAATTATTTTTGCCAAATTTATTTTGTAAATATGAGGGTCTGTAC
CTAAATTTAAAAAAAAAACACGTAGAACTAGGTATTTTGTTCTCTTCTTAGTAAATTTGTAGTGGTTGTATACTACACTAGCTGCAATTT
TCACATTTTTCTAATTCAGAAAGGTTTTTCTTATATTAGGGGAAAAAGTATTTATTTTAATATATAAAATCACTCTGAAAATCACTCTCA
TAAAAAATGGAGCGCATGTAAATTTTTATCAAAGAAAAATAAACAGGTGAATGGGGGATAGTGATTTTCTTTTTTCAGCACAGTCTACCT
CAGTGTATTGTTAAGATGTGATTCAATCATGGACATCTTTGAGATTTCAGAATTCTACCTGGAACCGGTCTGAATCAGGGAACGTGTGTA
TCAGCTGATTCGAATGCCAGGGACCAGTAAGAATTTTGAGGGAGGGAGTTGGGATGGAGAAGGTATGGCCTTTATGCGAGCATAGATCCT
TTTCTTCCTGGCTGGTAATATTCTTCTCTGAATTTAATCTTCCTTTAAAAAAAAATCCTCCATCTATTGTCACTATGTTCCCCAAACATA
AACTAAGTTCCAGGCTGTCATGATGTATCTGATATATGGGGTAACCCAGCAAGGTGTACCTTCCTTTGGTGAGAGATGGCTGCCGGGGCA
AAGACGGGCTTTGATTCAGAGCAAGCATTCCCACCTGTTCCATGGAATCCCCCTGAAGTGAGCACAAAGGTGCCCTGGGCTCCCTGATGG
TTTATGCCCACTCCTTTCAGGCTGGTGATGCACCTTACACACAAACACCTAATGCAATGTCTTTTTAAATTCTCCAAGTGGGATGGGAGC
ATGTGAGGGAAATTCCAATCCAAAACCCATTAATGTGCTGAACGCTTTTTTTTTTTTTTTTTTTTTTTTTGCAACAACACCTTGGACCTC
TGTGTTGGGGTTTGACTGACCTCAAGCTGATATTATTGGACCTTGTGCAGCTTTGATAACCCATGTGAGAGTCTAGGCAGGACCAGTGGG
GCCCAAATCTTGCTGCTCTTGTACTTTTAGGCACTGCCCTTGCAGACTCACCTTTCTCCACCTGCCCTGGAGAAAGGTAGGGTGTGCTGG
GCCTGCCCCTTGCAAATGGGATTCACCAGTTTCATTTATTTGACTCTACTGCCACAGTGAAAAGAGCAAACAGCTATTGGGTTGCAAACC
TCCTTTGACATTAGGAAATGTTGACTTTGTAACAATAAAACTTTGGTCCTAGAAAGACACGGTTGTCCTGGGAGTTTGTAGTGTTAAGTT
GCAACAACAACAACAAAAAGCAACAAAACCAGCTTAGGATAACACTTTTTGTTGCTTGTTCTTAAAGATGTCTCACTATGATTAAAACCC
TTTTCATTAATGTAGTGAAAGCCACACAGGAGTTCCTTCTTCCAGGAGGAGAATACCAAGCACATCACTTTCTCTCTGCATCAGTGATGT
CAAATACGCATCAGAAAATGTTCAGGTTTTAGGAGCTGTCCTAGGTGCTGTTTCATCATTGGAAGCAGTGAGAAAGAGAAGCACTGCTGC
TTGTCTGGATATAGGCTGAGGATGATTGAGAGAAGCTGTGGGAACTGACACAAGGGTCTGCATAGGTCATCCTGTGACCCTGGGGACTAT
GTTACCAACTGACAGACAGATCTTTCACTGTATCCTAGCAGGGCAGGTAGTCCACCAAGAAATGTGCTTATTGGATTGGGAGGTGTTTAT
TTGTAGTCTGCTGTAACACGTGTGAAAGAGCAGGAGCGTCATCAGCATATGACTTGCGCTGGTCATCCGGTAAATGGATGTGCTGTAGTC
CCAGTGCTAATCATTTCTCTCCTTCACAGTGGGTGGAAGTTTAGGGTTAAATGTCCTTTGAATGTCACCTGGTGAGTCCTTGACACCTTA
GGCTCTTCAGAAACAATGGTTTTGTTGAGGATGGGGAACAGGGAATGCCGATTTTATATACATGGTACACAGAGAGGGGTGTCACTTCAG
AAAATCTTCCAGCATGTTCTTCAGAATATTAATTTATATGCGAGGTGAGGTTGGGAATGAAAAGAACAGGTCAGCACTTTTTTTTTTCCT
AGAACATACAAAAGAACATGGTGGACTTTCAGGGAGTGCAATGGAAGGTGAATATTTCCTTAAGGGTCCCCGAGAAATGGGAGTGAGGGG
AGGGGACACAATGGCTTTTTGAGCTTACTTTTACCTTCTGATACTAGTCAAGGTCCAGAACCAGCCACCAGCCAAATTTCTATCTGGGTG
CGGGCCACTGAAAATCCTTGTTAAAAACCAGATCACAAATCTGGGGCTCTTGGTCCCATTGGAGAAGGAAGGAAGAGCCTCAAAATAAGT
GTGCACCCATGCACATATTCAGGAACAGCTTGTTTAGTCTTTACACTTTGCCTGAAAGTTGCTTCTCCTCGTCCCTTTGTGTGCCTGGGT
GGCCTCGGCCCTGTGCGTTGGCAACGCAGGATCAAATGTGCTGCAGCTTTTGCAGAAAACAACTCAGAAACACAAAACCCCCCAACAGCT
CAATTATTATTTTTTCAATGTTTTCCTACAAGAGCCAAGTAGCACCATGTACAGAAGACGCCTTTTTTTTTGGAATATTGAAATCGTTCT

>52380_52380_4_MDM1-INSR_MDM1_chr12_68696400_ENST00000411698_INSR_chr19_7152938_ENST00000341500_length(amino acids)=1316AA_BP=622
MPVRFKGLSEYQRNFLWKKSYLSESCNSSVGRKYPWAGLRSDQLGITKEPSFISKRRVPYHDPQISKSLEWNGAISESNVVASPEPEAPE
TPKSQEAEQKDVTQERVHSLEASRVPKRTRSHSADSRAEGASDVENNEGVTNHTPVNENVELEHSTKVLSENVDNGVFHNKSQFVPPFKG
NSVIHETEYKRNFKGLSPVKEPKLRNDLRENRNLETVSPERKSNKIDDRLKLEAEMELKDLHQPKRKLTPWKHQRLGKVNSEYRAKFLSP
AQYLYKAGAWTHVKGNMPNQGSLNAMWYAEVKELREKAEFYRKRVQGTHFSRDHLNQILSDSNCCWDVSSTTSSEGTVSSNIRALDLAGD
PTSHKTLQKCPSTEPEEKGNIVEEQPQKNTTEKLGVSAPTIPVRRRLAWDTENTSEDVQKQPGEKEEEDDNEEEGDRKTGKQAFMGEQEK
LDVREKSKADKMKEGSDSSVSSEKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAVLVSPSKMKPPAPEQRKRMTSQDCLETSKNDFTKKE
SRAVSLLTSPAAGIKTVDPLPLREDSEDNIHKFAEATLPVSKIPKYPTNPPGQLPSPPHVPSYWHPSRRIQGSLRDPEFQHNGLKLPSRT
WSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSST
SVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKE
PNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVF
LFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAV
KTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADG
MAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQP
YQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMEN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MDM1-INSR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MDM1-INSR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MDM1-INSR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource