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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MDM2-BRI3BP (FusionGDB2 ID:52391)

Fusion Gene Summary for MDM2-BRI3BP

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM2-BRI3BP
Fusion gene ID: 52391
HgeneTgene
Gene symbol

MDM2

BRI3BP

Gene ID

4193

140707

Gene nameMDM2 proto-oncogeneBRI3 binding protein
SynonymsACTFS|HDMX|LSKB|hdm2BNAS1|HCCR-1|HCCR-2|HCCRBP-1|HCCRBP-3|KG19
Cytomap

12q15

12q24.31

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, humBRI3-binding proteinI3-binding proteincervical cancer 1 proto-oncogene-binding protein KG19cervical cancer oncogene binding protein
Modification date2020032920200313
UniProtAcc.

Q8WY22

Ensembl transtripts involved in fusion geneENST00000478070, ENST00000258148, 
ENST00000258149, ENST00000350057, 
ENST00000462284, ENST00000299252, 
ENST00000348801, ENST00000356290, 
ENST00000360430, ENST00000393410, 
ENST00000393412, ENST00000393413, 
ENST00000428863, ENST00000517852, 
ENST00000540827, ENST00000544125, 
ENST00000544561, ENST00000545204, 
ENST00000341446, 
Fusion gene scores* DoF score39 X 20 X 11=85808 X 8 X 4=256
# samples 479
** MAII scorelog2(47/8580*10)=-4.19024498582191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MDM2 [Title/Abstract] AND BRI3BP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMDM2(69214154)-BRI3BP(125509890), # samples:2
Anticipated loss of major functional domain due to fusion event.MDM2-BRI3BP seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MDM2-BRI3BP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check buttonFusion gene breakpoints across MDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRI3BP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A7B2-01AMDM2chr12

69214154

+BRI3BPchr12

125509890

+
ChimerDB4PRADTCGA-KK-A7B2MDM2chr12

69214154

+BRI3BPchr12

125509890

+
ChimerDB4PRADTCGA-KK-A7B2MDM2chr12

69216191

+BRI3BPchr12

125509884

+


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Fusion Gene ORF analysis for MDM2-BRI3BP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000478070ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
In-frameENST00000258148ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
In-frameENST00000258149ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
In-frameENST00000350057ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
In-frameENST00000462284ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000258148ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000258149ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000299252ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000299252ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000348801ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000348801ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000350057ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000356290ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000356290ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000360430ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000360430ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000393410ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000393410ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000393412ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000393412ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000393413ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000393413ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000428863ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000428863ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000462284ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000478070ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000517852ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000517852ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000540827ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000540827ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000544125ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000544125ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000544561ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000544561ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+
intron-3CDSENST00000545204ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000545204ENST00000341446MDM2chr12

69216191

+BRI3BPchr12

125509884

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000462284MDM2chr1269214154+ENST00000341446BRI3BPchr12125509890+6547660266745159
ENST00000258149MDM2chr1269214154+ENST00000341446BRI3BPchr12125509890+6532645251730159
ENST00000258148MDM2chr1269214154+ENST00000341446BRI3BPchr12125509890+625937214457147
ENST00000350057MDM2chr1269214154+ENST00000341446BRI3BPchr12125509890+615226525912232119

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000462284ENST00000341446MDM2chr1269214154+BRI3BPchr12125509890+0.0065610650.9934389
ENST00000258149ENST00000341446MDM2chr1269214154+BRI3BPchr12125509890+0.0064666440.9935334
ENST00000258148ENST00000341446MDM2chr1269214154+BRI3BPchr12125509890+0.0056071270.9943929
ENST00000350057ENST00000341446MDM2chr1269214154+BRI3BPchr12125509890+0.0210229160.9789771

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Fusion Genomic Features for MDM2-BRI3BP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MDM2-BRI3BP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69214154/chr12:125509890)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BRI3BP

Q8WY22

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in tumorigenesis and may function by stabilizing p53/TP53. {ECO:0000269|PubMed:17943721}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+5926_109113437.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+51126_109119498.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+591_101113437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+5111_101119498.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneBRI3BPchr12:69214154chr12:125509890ENST0000034144603217_2470252.0Coiled coilOntology_term=ECO:0000255
TgeneBRI3BPchr12:69214154chr12:125509890ENST0000034144603125_1450252.0TransmembraneHelical
TgeneBRI3BPchr12:69214154chr12:125509890ENST000003414460313_330252.0TransmembraneHelical
TgeneBRI3BPchr12:69214154chr12:125509890ENST0000034144603146_1660252.0TransmembraneHelical
TgeneBRI3BPchr12:69214154chr12:125509890ENST0000034144603185_2050252.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59210_215113437.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59243_301113437.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15210_2150322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15243_3010322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13210_2150266.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13243_3010266.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16210_2150322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16243_3010322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14210_2150297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14243_3010297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14210_2150271.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14243_3010271.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511210_215119498.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511243_301119498.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15210_2150297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15243_3010297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+1526_1090322.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+1326_1090266.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+1626_1090322.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+1426_1090297.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+1326_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+1226_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+1426_1090271.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+1526_1090297.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59179_185113437.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59190_202113437.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59466_473113437.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15179_1850322.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15190_2020322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15466_4730322.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13179_1850266.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13190_2020266.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13466_4730266.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16179_1850322.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16190_2020322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16466_4730322.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14179_1850297.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14190_2020297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14466_4730297.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14179_1850271.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14190_2020271.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14466_4730271.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511179_185119498.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511190_202119498.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511466_473119498.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15179_1850297.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15190_2020297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15466_4730297.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59210_304113437.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59242_331113437.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+151_1010322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15210_3040322.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15242_3310322.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+131_1010266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13210_3040266.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13242_3310266.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+161_1010322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16210_3040322.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16242_3310322.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+141_1010297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14210_3040297.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14242_3310297.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+131_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+121_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+141_1010271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14210_3040271.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14242_3310271.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511210_304119498.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511242_331119498.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+151_1010297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15210_3040297.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15242_3310297.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59299_328113437.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59438_479113437.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15299_3280322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15438_4790322.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13299_3280266.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13438_4790266.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16299_3280322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16438_4790322.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14299_3280297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14438_4790297.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14299_3280271.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14438_4790271.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511299_328119498.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511438_479119498.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15299_3280297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15438_4790297.0Zinc fingerRING-type


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Fusion Gene Sequence for MDM2-BRI3BP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52391_52391_1_MDM2-BRI3BP_MDM2_chr12_69214154_ENST00000258148_BRI3BP_chr12_125509890_ENST00000341446_length(transcript)=6259nt_BP=372nt
CGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTC
CAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTA
TGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATG
ATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAG
TCAATCAGCAGGTGGAGCACCTGGAGAAGCAGGTCAGACTGCTCAACATCCGTCTCAACCGGGTGCTCGAGAGCCTGGACCGCTCCAAGG
ACAAGTGAAGGTCAGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACCCCA
AACAATCTTAATAAACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGACACATTCCCAGA
AGAGCGGAAAGATCATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACAAAGGATATAACCATATTT
AGTTGTACAGTAAGAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCTTTTGTAAGGTTTTTTAAT
AAAGGCAGATTGAGTCAAGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAAAAGTTTAAATGCGAGCGT
TTGTTTTCACAGCTTAGGGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTTTATTTCATGTTATTTTTG
GTGGATGTTGACTTAGTTCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAACCTCTTTTGGATCCTAGA
GACCCCTGCCAAGCCCCCATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTTCGA
TGTATTTTAACCTCAACATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGCCAGGAAGTACCTGGTAAG
GATTGGAGATTGCTCCAGAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGCTATACCCTTGAGGGTTTT
TTTTTTTTTCTTTTGATTTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATATTGCTGCTTAGAAAGATC
CTCAGGAACAATTAGCAGCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGATACACAGGTGCTTTTTATC
TGAAATCTGTTGTGTCCTCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAAGGG
AGTTTCAGAAGGTGTGGCTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGCAGT
GGCTGATGCCTGTAATCCCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGT
GAAACCCCCGTCTCTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAGGAG
AATTGCTTGAACCTGGGAGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGCAAGACTTCATCTTA
AAAAAAAAAAAAAAAGCCCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTTACCTGGCCACAGATGTAC
CCTGGCAACCCGCTCACAGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGACCTTATGGTCCAGGTCTC
AGTTTGGAGAAGATTTAGCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAGTATCTGGAAAACAGATGC
AGATGTTTTTGTGGATGTTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACTCTCCTGGAGAGTTCCATT
CACTTCCTGAAACGTGCACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGGTGG
CTCACCCCTATAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAGTGA
AACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAA
TCGCTTGAACATGGGAGGCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTCAAA
AAAAATTATTTGCTGGATCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAGTGGCACCATCTCGGCTCA
CTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGCCCACCATCATGCCCGGCT
AATTTTTTATATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCC
TCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTGGAACACAGGATTACTGGG
TTGAAATCATTCTAGTTTTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTCGGGAGGTCATCTCTATCT
TCTTTCCTTTTGTGCATTTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAAAACATGGCATTCTGTGCG
CAAAGCTAATGATCGCCAGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCACTG
GGCTGGGTGTAATACCCGCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTATTGAGATCTCGATAAGATC
ATCATTTTAACTTGTATTCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCATCAATTCAAAATTGCTGT
CGAAAATATGCACTATTTTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATACATTCTGGTGAAAGATGT
CTTCATTTTTAATGAAAGAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGATTATTTGAAACTCTGATA
GAAATCCTAGATGCTAGATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATCTTACCCCAAAATAATTGG
GGATTTTTTTGTTCCTTCTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCGCCACATGTCTTTGTTTTT
TTCTCTCTTTTGTATGTGGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGAATA
TATTAGCGTAACACTTCACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGACTCAGTGTTTAAAATATCT
TAATCAGTGTTAATTTCCCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCCAGAAAAGGAAAAGGACCA
GCCCTCTCTAGATTGCTGGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAGCAAAGATGCTTTTGTGGA
GTGCAAACCTTTCATAAATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGAT
CACTTGCGGTCGGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAAAAAAAAAAAAAAAAAAAA
ATAGCCAGGTGTGGTGGTGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAACCTGGGAGGCAGAGGTTGC
AGTGAACTGAGATCACACCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGTATA
TATATGTATATATATATACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAGCCC
CCATATCATTTCTGGTAACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGTCTTAATTCACAAAGGGTA
AGTGAATGCCGTTGAAAGGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGGGAA
CTGGGACTATGTCTTTATGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGGTCA
GTGATTAGGAAGACTATAATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTGGCC
CTGTGATTCAGGCTTATGGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGTTGCTAGTGGAAATCCTGA
ATTGCTTCCTTTCTGTGATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGACACCTGATAACTTCTCCC
TGATGGGTTTCCGAACTGGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAGGGG
TCAGCTGCCCCACTCCTGACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCATTTGAATAGTTGGACTTTG
ACTCCTCACTTGTGAATAATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGACAACCATCAGTGTGATGTA
TAGTATCTGGTGTAAACAAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAGGAGGTGCACCAGTACCAG
TTTTTCTCTTGTGGTGGCTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTGGTATTATTGACCATGTGT
TCTCATGTCTTTTTGCAGATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTCTGAATACCATGTAATTAA
ACTGATTAACTTGTGATGGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTCTTAACTGGAAATCACACT
TGTGAGGTATGGTATCCATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAATTTTGTATAGCATTTAATT
TGGCACTTAATATAAATCCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCTTGG
GAAACTGATTCTACAAATATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACATTCCTCTTATTTATTAAAT
CACTGGCTTTGGTGTTATGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGCTTAATAAATGTTTATTGT

>52391_52391_1_MDM2-BRI3BP_MDM2_chr12_69214154_ENST00000258148_BRI3BP_chr12_125509890_ENST00000341446_length(amino acids)=147AA_BP=120
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGD

--------------------------------------------------------------
>52391_52391_2_MDM2-BRI3BP_MDM2_chr12_69214154_ENST00000258149_BRI3BP_chr12_125509890_ENST00000341446_length(transcript)=6532nt_BP=645nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATA
CTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAA
ATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAG
TAGTCAATCAGCAGGTGGAGCACCTGGAGAAGCAGGTCAGACTGCTCAACATCCGTCTCAACCGGGTGCTCGAGAGCCTGGACCGCTCCA
AGGACAAGTGAAGGTCAGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACC
CCAAACAATCTTAATAAACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGACACATTCCC
AGAAGAGCGGAAAGATCATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACAAAGGATATAACCATA
TTTAGTTGTACAGTAAGAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCTTTTGTAAGGTTTTTT
AATAAAGGCAGATTGAGTCAAGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAAAAGTTTAAATGCGAG
CGTTTGTTTTCACAGCTTAGGGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTTTATTTCATGTTATTT
TTGGTGGATGTTGACTTAGTTCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAACCTCTTTTGGATCCT
AGAGACCCCTGCCAAGCCCCCATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTT
CGATGTATTTTAACCTCAACATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGCCAGGAAGTACCTGGT
AAGGATTGGAGATTGCTCCAGAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGCTATACCCTTGAGGGT
TTTTTTTTTTTTCTTTTGATTTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATATTGCTGCTTAGAAAG
ATCCTCAGGAACAATTAGCAGCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGATACACAGGTGCTTTTT
ATCTGAAATCTGTTGTGTCCTCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAA
GGGAGTTTCAGAAGGTGTGGCTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGC
AGTGGCTGATGCCTGTAATCCCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACAT
GGTGAAACCCCCGTCTCTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAG
GAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGCAAGACTTCATC
TTAAAAAAAAAAAAAAAAGCCCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTTACCTGGCCACAGATG
TACCCTGGCAACCCGCTCACAGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGACCTTATGGTCCAGGT
CTCAGTTTGGAGAAGATTTAGCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAGTATCTGGAAAACAGA
TGCAGATGTTTTTGTGGATGTTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACTCTCCTGGAGAGTTCC
ATTCACTTCCTGAAACGTGCACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGG
TGGCTCACCCCTATAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAG
TGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGA
GAATCGCTTGAACATGGGAGGCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTC
AAAAAAAATTATTTGCTGGATCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAGTGGCACCATCTCGGC
TCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGCCCACCATCATGCCCG
GCTAATTTTTTATATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCG
GCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTGGAACACAGGATTACT
GGGTTGAAATCATTCTAGTTTTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTCGGGAGGTCATCTCTA
TCTTCTTTCCTTTTGTGCATTTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAAAACATGGCATTCTGT
GCGCAAAGCTAATGATCGCCAGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCA
CTGGGCTGGGTGTAATACCCGCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTATTGAGATCTCGATAAG
ATCATCATTTTAACTTGTATTCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCATCAATTCAAAATTGC
TGTCGAAAATATGCACTATTTTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATACATTCTGGTGAAAGA
TGTCTTCATTTTTAATGAAAGAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGATTATTTGAAACTCTG
ATAGAAATCCTAGATGCTAGATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATCTTACCCCAAAATAAT
TGGGGATTTTTTTGTTCCTTCTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCGCCACATGTCTTTGTT
TTTTTCTCTCTTTTGTATGTGGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGA
ATATATTAGCGTAACACTTCACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGACTCAGTGTTTAAAATA
TCTTAATCAGTGTTAATTTCCCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCCAGAAAAGGAAAAGGA
CCAGCCCTCTCTAGATTGCTGGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAGCAAAGATGCTTTTGT
GGAGTGCAAACCTTTCATAAATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTG
GATCACTTGCGGTCGGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAAAAAAAAAAAAAAAAA
AAAATAGCCAGGTGTGGTGGTGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAACCTGGGAGGCAGAGGT
TGCAGTGAACTGAGATCACACCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGT
ATATATATGTATATATATATACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAG
CCCCCATATCATTTCTGGTAACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGTCTTAATTCACAAAGG
GTAAGTGAATGCCGTTGAAAGGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGG
GAACTGGGACTATGTCTTTATGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGG
TCAGTGATTAGGAAGACTATAATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTG
GCCCTGTGATTCAGGCTTATGGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGTTGCTAGTGGAAATCC
TGAATTGCTTCCTTTCTGTGATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGACACCTGATAACTTCT
CCCTGATGGGTTTCCGAACTGGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAG
GGGTCAGCTGCCCCACTCCTGACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCATTTGAATAGTTGGACT
TTGACTCCTCACTTGTGAATAATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGACAACCATCAGTGTGAT
GTATAGTATCTGGTGTAAACAAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAGGAGGTGCACCAGTAC
CAGTTTTTCTCTTGTGGTGGCTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTGGTATTATTGACCATG
TGTTCTCATGTCTTTTTGCAGATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTCTGAATACCATGTAAT
TAAACTGATTAACTTGTGATGGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTCTTAACTGGAAATCAC
ACTTGTGAGGTATGGTATCCATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAATTTTGTATAGCATTTA
ATTTGGCACTTAATATAAATCCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCT
TGGGAAACTGATTCTACAAATATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACATTCCTCTTATTTATTA
AATCACTGGCTTTGGTGTTATGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGCTTAATAAATGTTTAT

>52391_52391_2_MDM2-BRI3BP_MDM2_chr12_69214154_ENST00000258149_BRI3BP_chr12_125509890_ENST00000341446_length(amino acids)=159AA_BP=132
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ

--------------------------------------------------------------
>52391_52391_3_MDM2-BRI3BP_MDM2_chr12_69214154_ENST00000350057_BRI3BP_chr12_125509890_ENST00000341446_length(transcript)=6152nt_BP=265nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGTGGAG
CACCTGGAGAAGCAGGTCAGACTGCTCAACATCCGTCTCAACCGGGTGCTCGAGAGCCTGGACCGCTCCAAGGACAAGTGAAGGTCAGCC
GGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACCCCAAACAATCTTAATAAACA
CGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGACACATTCCCAGAAGAGCGGAAAGATCATT
GACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACAAAGGATATAACCATATTTAGTTGTACAGTAAGAGA
AATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCTTTTGTAAGGTTTTTTAATAAAGGCAGATTGAGTCA
AGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAAAAGTTTAAATGCGAGCGTTTGTTTTCACAGCTTAG
GGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTTTATTTCATGTTATTTTTGGTGGATGTTGACTTAGT
TCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAACCTCTTTTGGATCCTAGAGACCCCTGCCAAGCCCC
CATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTTCGATGTATTTTAACCTCAAC
ATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGCCAGGAAGTACCTGGTAAGGATTGGAGATTGCTCCA
GAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGCTATACCCTTGAGGGTTTTTTTTTTTTTCTTTTGAT
TTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATATTGCTGCTTAGAAAGATCCTCAGGAACAATTAGCA
GCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGATACACAGGTGCTTTTTATCTGAAATCTGTTGTGTCC
TCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAAGGGAGTTTCAGAAGGTGTGG
CTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGCAGTGGCTGATGCCTGTAATC
CCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCCGTCTCTAC
TAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGG
AGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGCAAGACTTCATCTTAAAAAAAAAAAAAAAAGC
CCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTTACCTGGCCACAGATGTACCCTGGCAACCCGCTCAC
AGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGACCTTATGGTCCAGGTCTCAGTTTGGAGAAGATTTA
GCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAGTATCTGGAAAACAGATGCAGATGTTTTTGTGGATG
TTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACTCTCCTGGAGAGTTCCATTCACTTCCTGAAACGTGC
ACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGGTGGCTCACCCCTATAATCCC
AACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAGTGAAACCCCGTCTCTACTAA
AAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAATCGCTTGAACATGGGAG
GCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTCAAAAAAAATTATTTGCTGGA
TCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAGTGGCACCATCTCGGCTCACTGCAAGCTCCGCCTCC
TGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGCCCACCATCATGCCCGGCTAATTTTTTATATTTTTA
GTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGAT
TACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTGGAACACAGGATTACTGGGTTGAAATCATTCTAGTT
TTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTCGGGAGGTCATCTCTATCTTCTTTCCTTTTGTGCAT
TTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAAAACATGGCATTCTGTGCGCAAAGCTAATGATCGCC
AGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCACTGGGCTGGGTGTAATACCC
GCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTATTGAGATCTCGATAAGATCATCATTTTAACTTGTAT
TCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCATCAATTCAAAATTGCTGTCGAAAATATGCACTATT
TTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATACATTCTGGTGAAAGATGTCTTCATTTTTAATGAAA
GAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGATTATTTGAAACTCTGATAGAAATCCTAGATGCTAG
ATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATCTTACCCCAAAATAATTGGGGATTTTTTTGTTCCTT
CTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCGCCACATGTCTTTGTTTTTTTCTCTCTTTTGTATGT
GGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGAATATATTAGCGTAACACTTC
ACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGACTCAGTGTTTAAAATATCTTAATCAGTGTTAATTTC
CCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCCAGAAAAGGAAAAGGACCAGCCCTCTCTAGATTGCT
GGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAGCAAAGATGCTTTTGTGGAGTGCAAACCTTTCATAA
ATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGCGGTCGGGAGT
TCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAAAAAAAAAAAAAAAAAAAAATAGCCAGGTGTGGTGG
TGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAACCTGGGAGGCAGAGGTTGCAGTGAACTGAGATCACA
CCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGTATATATATGTATATATATAT
ACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAGCCCCCATATCATTTCTGGTA
ACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGTCTTAATTCACAAAGGGTAAGTGAATGCCGTTGAAA
GGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGGGAACTGGGACTATGTCTTTA
TGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGGTCAGTGATTAGGAAGACTAT
AATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTGGCCCTGTGATTCAGGCTTAT
GGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGTTGCTAGTGGAAATCCTGAATTGCTTCCTTTCTGTG
ATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGACACCTGATAACTTCTCCCTGATGGGTTTCCGAACT
GGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAGGGGTCAGCTGCCCCACTCCT
GACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCATTTGAATAGTTGGACTTTGACTCCTCACTTGTGAAT
AATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGACAACCATCAGTGTGATGTATAGTATCTGGTGTAAAC
AAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAGGAGGTGCACCAGTACCAGTTTTTCTCTTGTGGTGG
CTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTGGTATTATTGACCATGTGTTCTCATGTCTTTTTGCA
GATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTCTGAATACCATGTAATTAAACTGATTAACTTGTGAT
GGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTCTTAACTGGAAATCACACTTGTGAGGTATGGTATCC
ATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAATTTTGTATAGCATTTAATTTGGCACTTAATATAAAT
CCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCTTGGGAAACTGATTCTACAAA
TATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACATTCCTCTTATTTATTAAATCACTGGCTTTGGTGTTA
TGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGCTTAATAAATGTTTATTGTAATTTTGTTGTATGGAC

>52391_52391_3_MDM2-BRI3BP_MDM2_chr12_69214154_ENST00000350057_BRI3BP_chr12_125509890_ENST00000341446_length(amino acids)=119AA_BP=
MRRSLTLLLRLECGGMISADCNLRLPCSSDSPASASQVAGITGAHHQAWLIFVFLVETGFHSVGRAGLKLLTSGDPPALASQSVGIIGVS

--------------------------------------------------------------
>52391_52391_4_MDM2-BRI3BP_MDM2_chr12_69214154_ENST00000462284_BRI3BP_chr12_125509890_ENST00000341446_length(transcript)=6547nt_BP=660nt
GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC
CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC
CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA
GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG
TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC
AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA
TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT
ACAGGAACTTGGTAGTAGTCAATCAGCAGGTGGAGCACCTGGAGAAGCAGGTCAGACTGCTCAACATCCGTCTCAACCGGGTGCTCGAGA
GCCTGGACCGCTCCAAGGACAAGTGAAGGTCAGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGA
AAAAAACCCCAAACCCCAAACAATCTTAATAAACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTC
TTAGGACACATTCCCAGAAGAGCGGAAAGATCATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACA
AAGGATATAACCATATTTAGTTGTACAGTAAGAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCT
TTTGTAAGGTTTTTTAATAAAGGCAGATTGAGTCAAGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAA
AAGTTTAAATGCGAGCGTTTGTTTTCACAGCTTAGGGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTT
TATTTCATGTTATTTTTGGTGGATGTTGACTTAGTTCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAA
CCTCTTTTGGATCCTAGAGACCCCTGCCAAGCCCCCATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTT
CTTCCCTCTGTGCTTCGATGTATTTTAACCTCAACATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGC
CAGGAAGTACCTGGTAAGGATTGGAGATTGCTCCAGAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGC
TATACCCTTGAGGGTTTTTTTTTTTTTCTTTTGATTTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATA
TTGCTGCTTAGAAAGATCCTCAGGAACAATTAGCAGCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGAT
ACACAGGTGCTTTTTATCTGAAATCTGTTGTGTCCTCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGT
GGGGATCCTGGGCAAGGGAGTTTCAGAAGGTGTGGCTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAG
CCCTAGGCCAGGCGCAGTGGCTGATGCCTGTAATCCCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGAC
CAGCCTGGCCAACATGGTGAAACCCCCGTCTCTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTC
AGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACA
GAGCAAGACTTCATCTTAAAAAAAAAAAAAAAAGCCCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTT
ACCTGGCCACAGATGTACCCTGGCAACCCGCTCACAGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGA
CCTTATGGTCCAGGTCTCAGTTTGGAGAAGATTTAGCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAG
TATCTGGAAAACAGATGCAGATGTTTTTGTGGATGTTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACT
CTCCTGGAGAGTTCCATTCACTTCCTGAAACGTGCACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGA
GCAGGCTGGGCAGGGTGGCTCACCCCTATAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCA
GCCCGGCCAACAGAGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGG
GAGGCTGAGGCTGGAGAATCGCTTGAACATGGGAGGCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGA
GTGAGACTCCGTCTCAAAAAAAATTATTTGCTGGATCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAG
TGGCACCATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGC
CCACCATCATGCCCGGCTAATTTTTTATATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGT
GATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTG
GAACACAGGATTACTGGGTTGAAATCATTCTAGTTTTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTC
GGGAGGTCATCTCTATCTTCTTTCCTTTTGTGCATTTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAA
AACATGGCATTCTGTGCGCAAAGCTAATGATCGCCAGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTA
AGGCTTAAGCTGTCACTGGGCTGGGTGTAATACCCGCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTAT
TGAGATCTCGATAAGATCATCATTTTAACTTGTATTCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCA
TCAATTCAAAATTGCTGTCGAAAATATGCACTATTTTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATA
CATTCTGGTGAAAGATGTCTTCATTTTTAATGAAAGAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGA
TTATTTGAAACTCTGATAGAAATCCTAGATGCTAGATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATC
TTACCCCAAAATAATTGGGGATTTTTTTGTTCCTTCTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCG
CCACATGTCTTTGTTTTTTTCTCTCTTTTGTATGTGGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTAT
CTTCAGGGCTGTAGAATATATTAGCGTAACACTTCACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGAC
TCAGTGTTTAAAATATCTTAATCAGTGTTAATTTCCCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCC
AGAAAAGGAAAAGGACCAGCCCTCTCTAGATTGCTGGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAG
CAAAGATGCTTTTGTGGAGTGCAAACCTTTCATAAATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGG
AGGCCAAGGCGGGTGGATCACTTGCGGTCGGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAA
AAAAAAAAAAAAAAAAAAATAGCCAGGTGTGGTGGTGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAAC
CTGGGAGGCAGAGGTTGCAGTGAACTGAGATCACACCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAA
AGTGTGTGTGTGTGTATATATATGTATATATATATACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTT
TGCTTTGGATTTCAGCCCCCATATCATTTCTGGTAACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGT
CTTAATTCACAAAGGGTAAGTGAATGCCGTTGAAAGGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGA
GGCAGCGATGTCAGGGAACTGGGACTATGTCTTTATGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGA
ACGCAAAGGTTTGGGTCAGTGATTAGGAAGACTATAATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGC
TTAGTCGCTCATCTGGCCCTGTGATTCAGGCTTATGGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGT
TGCTAGTGGAAATCCTGAATTGCTTCCTTTCTGTGATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGA
CACCTGATAACTTCTCCCTGATGGGTTTCCGAACTGGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATT
CCTGAGGCTCCTAAGGGGTCAGCTGCCCCACTCCTGACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCAT
TTGAATAGTTGGACTTTGACTCCTCACTTGTGAATAATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGAC
AACCATCAGTGTGATGTATAGTATCTGGTGTAAACAAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAG
GAGGTGCACCAGTACCAGTTTTTCTCTTGTGGTGGCTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTG
GTATTATTGACCATGTGTTCTCATGTCTTTTTGCAGATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTC
TGAATACCATGTAATTAAACTGATTAACTTGTGATGGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTC
TTAACTGGAAATCACACTTGTGAGGTATGGTATCCATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAAT
TTTGTATAGCATTTAATTTGGCACTTAATATAAATCCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTT
TAGTTTCGTGAGCCTTGGGAAACTGATTCTACAAATATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACAT
TCCTCTTATTTATTAAATCACTGGCTTTGGTGTTATGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGC

>52391_52391_4_MDM2-BRI3BP_MDM2_chr12_69214154_ENST00000462284_BRI3BP_chr12_125509890_ENST00000341446_length(amino acids)=159AA_BP=132
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MDM2-BRI3BP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59170_306113.33333333333333437.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15170_3060.0322.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13170_3060.0266.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16170_3060322.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14170_3060.0297.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13170_3060219.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12170_3060.0219.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14170_3060271.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511170_306119.33333333333333498.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15170_3060297.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59150_230113.33333333333333437.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15150_2300.0322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13150_2300.0266.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16150_2300322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14150_2300.0297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13150_2300219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12150_2300.0219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14150_2300271.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511150_230119.33333333333333498.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15150_2300297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59223_232113.33333333333333437.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15223_2320.0322.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13223_2320.0266.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16223_2320322.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14223_2320.0297.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13223_2320219.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12223_2320.0219.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14223_2320271.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511223_232119.33333333333333498.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15223_2320297.0USP7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MDM2-BRI3BP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MDM2-BRI3BP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource