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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MDM2-EGFR (FusionGDB2 ID:52402)

Fusion Gene Summary for MDM2-EGFR

Fusion gene summary

Fusion gene information	Fusion gene name: MDM2-EGFR
	Fusion gene ID: 52402
		Hgene	Tgene
	Gene symbol	MDM2	EGFR
	Gene ID	4193	1956
	Gene name	MDM2 proto-oncogene	epidermal growth factor receptor
	Synonyms	ACTFS\|HDMX\|LSKB\|hdm2	ERBB\|ERBB1\|HER1\|NISBD2\|PIG61\|mENA
	Cytomap	12q15	7p11.2
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum	epidermal growth factor receptoravian erythroblastic leukemia viral (v-erb-b) oncogene homologcell growth inhibiting protein 40cell proliferation-inducing protein 61epidermal growth factor receptor tyrosine kinase domainerb-b2 receptor tyrosine kinas
	Modification date	20200329	20200329
	UniProtAcc	.	P00533
	Ensembl transtripts involved in fusion gene	ENST00000258148, ENST00000258149, ENST00000299252, ENST00000348801, ENST00000350057, ENST00000356290, ENST00000360430, ENST00000393410, ENST00000393412, ENST00000393413, ENST00000428863, ENST00000462284, ENST00000478070, ENST00000517852, ENST00000540827, ENST00000544561, ENST00000545204, ENST00000544125,	ENST00000275493, ENST00000420316, ENST00000442591, ENST00000454757, ENST00000463948, ENST00000342916, ENST00000344576, ENST00000455089,
Fusion gene scores	* DoF score	39 X 20 X 11=8580	17 X 20 X 8=2720
	# samples	47	22
	** MAII score	log2(47/8580*10)=-4.19024498582191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/2720*10)=-3.62803122261304 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MDM2 [Title/Abstract] AND EGFR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MDM2(69203072)-EGFR(55231426), # samples:2
Anticipated loss of major functional domain due to fusion event.	MDM2-EGFR seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. MDM2-EGFR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MDM2-EGFR seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. MDM2-EGFR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MDM2-EGFR seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MDM2	GO:0000122	negative regulation of transcription by RNA polymerase II	9271120\|17310983
Hgene	MDM2	GO:0006511	ubiquitin-dependent protein catabolic process	11278372\|15314173\|16173922\|17310983
Hgene	MDM2	GO:0016567	protein ubiquitination	9450543\|15878855\|19656744\|20153724
Hgene	MDM2	GO:0031648	protein destabilization	9529249\|10360174\|15314173
Hgene	MDM2	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	11278372
Hgene	MDM2	GO:0034504	protein localization to nucleus	10360174
Hgene	MDM2	GO:0042176	regulation of protein catabolic process	9153395
Hgene	MDM2	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	9529249\|10360174
Hgene	MDM2	GO:0045184	establishment of protein localization	10360174
Hgene	MDM2	GO:0045892	negative regulation of transcription, DNA-templated	9271120
Hgene	MDM2	GO:0065003	protein-containing complex assembly	10608892\|12915590
Hgene	MDM2	GO:0071157	negative regulation of cell cycle arrest	9529249
Hgene	MDM2	GO:0071480	cellular response to gamma radiation	16213212
Hgene	MDM2	GO:0072717	cellular response to actinomycin D	15314173
Hgene	MDM2	GO:1901797	negative regulation of signal transduction by p53 class mediator	16173922
Tgene	EGFR	GO:0001934	positive regulation of protein phosphorylation	20551055
Tgene	EGFR	GO:0007165	signal transduction	10572067
Tgene	EGFR	GO:0007166	cell surface receptor signaling pathway	7736574
Tgene	EGFR	GO:0007173	epidermal growth factor receptor signaling pathway	7736574\|12435727
Tgene	EGFR	GO:0008283	cell proliferation	17115032
Tgene	EGFR	GO:0008284	positive regulation of cell proliferation	7736574
Tgene	EGFR	GO:0010750	positive regulation of nitric oxide mediated signal transduction	12828935
Tgene	EGFR	GO:0018108	peptidyl-tyrosine phosphorylation	22732145
Tgene	EGFR	GO:0030307	positive regulation of cell growth	15467833
Tgene	EGFR	GO:0042177	negative regulation of protein catabolic process	17115032
Tgene	EGFR	GO:0042327	positive regulation of phosphorylation	15082764
Tgene	EGFR	GO:0043406	positive regulation of MAP kinase activity	10572067
Tgene	EGFR	GO:0045739	positive regulation of DNA repair	17115032
Tgene	EGFR	GO:0045740	positive regulation of DNA replication	17115032
Tgene	EGFR	GO:0045944	positive regulation of transcription by RNA polymerase II	20551055
Tgene	EGFR	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Tgene	EGFR	GO:0050999	regulation of nitric-oxide synthase activity	12828935
Tgene	EGFR	GO:0070141	response to UV-A	18483258
Tgene	EGFR	GO:0070374	positive regulation of ERK1 and ERK2 cascade	20551055
Tgene	EGFR	GO:0071392	cellular response to estradiol stimulus	20551055
Tgene	EGFR	GO:1900020	positive regulation of protein kinase C activity	22732145
Tgene	EGFR	GO:1903078	positive regulation of protein localization to plasma membrane	22732145

Fusion gene breakpoints across MDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EGFR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-19-2624-01A	MDM2	chr12	69203072	-	EGFR	chr7	55231426	+
ChimerDB4	GBM	TCGA-19-2624-01A	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
ChimerDB4	GBM	TCGA-19-2624	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+

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Fusion Gene ORF analysis for MDM2-EGFR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000258148	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258148	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258148	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258148	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258148	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258148	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258148	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258148	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258148	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258148	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258149	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258149	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258149	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258149	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258149	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258149	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258149	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258149	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258149	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258149	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000299252	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000299252	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000299252	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000299252	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000299252	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000299252	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000299252	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000299252	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000299252	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000299252	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000348801	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000348801	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000348801	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000348801	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000348801	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000348801	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000348801	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000348801	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000348801	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000348801	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000350057	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000350057	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000350057	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000350057	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000350057	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000350057	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000350057	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000350057	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000350057	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000350057	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000356290	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000356290	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000356290	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000356290	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000356290	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000356290	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000356290	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000356290	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000356290	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000356290	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000360430	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000360430	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000360430	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000360430	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000360430	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000360430	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000360430	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000360430	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000360430	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000360430	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393410	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393410	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393410	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393410	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393410	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393410	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393410	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393410	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393410	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393410	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393412	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393412	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393412	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393412	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393412	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393412	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393412	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393412	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393412	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393412	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393413	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393413	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393413	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393413	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393413	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393413	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393413	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393413	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393413	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393413	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000428863	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000428863	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000428863	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000428863	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000428863	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000428863	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000428863	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000428863	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000428863	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000428863	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000462284	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000462284	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000462284	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000462284	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000462284	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000462284	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000462284	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000462284	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000462284	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000462284	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000478070	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000478070	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000478070	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000478070	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000478070	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000478070	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000478070	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000478070	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000478070	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000478070	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000517852	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000517852	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000517852	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000517852	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000517852	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000517852	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000517852	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000517852	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000517852	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000517852	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000540827	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000540827	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000540827	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000540827	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000540827	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000540827	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000540827	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000540827	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000540827	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000540827	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000544561	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000544561	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000544561	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000544561	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000544561	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000544561	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000544561	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000544561	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000544561	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000544561	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000545204	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000545204	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000545204	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000545204	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000545204	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000545204	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000545204	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000545204	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000545204	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000545204	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000258148	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000258148	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000258148	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000258148	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000258148	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000258148	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000258149	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000258149	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000258149	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000258149	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000258149	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000258149	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000299252	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000299252	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000299252	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000299252	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000299252	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000299252	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000348801	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000348801	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000348801	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000348801	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000348801	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000348801	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000350057	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000350057	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000350057	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000350057	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000350057	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000350057	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000356290	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000356290	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000356290	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000356290	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000356290	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000356290	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000360430	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000360430	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000360430	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000360430	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000360430	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000360430	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393410	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393410	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393410	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393410	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393410	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393410	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393412	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393412	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393412	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393412	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393412	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393412	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393413	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393413	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393413	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393413	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393413	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393413	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000428863	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000428863	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000428863	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000428863	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000428863	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000428863	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000462284	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000462284	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000462284	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000462284	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000462284	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000462284	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000478070	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000478070	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000478070	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000478070	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000478070	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000478070	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000517852	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000517852	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000517852	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000517852	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000517852	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000517852	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000540827	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000540827	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000540827	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000540827	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000540827	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000540827	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000544561	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000544561	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000544561	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000544561	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000544561	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000544561	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000545204	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000545204	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000545204	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000545204	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000545204	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000545204	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-3CDS	ENST00000544125	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-3CDS	ENST00000544125	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-3CDS	ENST00000544125	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-3CDS	ENST00000544125	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-3CDS	ENST00000544125	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-3CDS	ENST00000544125	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-intron	ENST00000544125	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-intron	ENST00000544125	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-intron	ENST00000544125	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-intron	ENST00000544125	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-intron	ENST00000544125	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-intron	ENST00000544125	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-intron	ENST00000544125	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-intron	ENST00000544125	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-intron	ENST00000544125	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-intron	ENST00000544125	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MDM2-EGFR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MDM2-EGFR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:69203072/:55231426)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	EGFR P00533
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). {ECO:0000250\|UniProtKB:Q01279, ECO:0000269\|PubMed:10805725, ECO:0000269\|PubMed:11116146, ECO:0000269\|PubMed:11483589, ECO:0000269\|PubMed:11602604, ECO:0000269\|PubMed:12297049, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12873986, ECO:0000269\|PubMed:15374980, ECO:0000269\|PubMed:15590694, ECO:0000269\|PubMed:15611079, ECO:0000269\|PubMed:17115032, ECO:0000269\|PubMed:17909029, ECO:0000269\|PubMed:19560417, ECO:0000269\|PubMed:20462955, ECO:0000269\|PubMed:20837704, ECO:0000269\|PubMed:21258366, ECO:0000269\|PubMed:27153536, ECO:0000269\|PubMed:2790960, ECO:0000269\|PubMed:7679104, ECO:0000269\|PubMed:8144591, ECO:0000269\|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269\|PubMed:21516087}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MDM2-EGFR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MDM2-EGFR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MDM2-EGFR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MDM2-EGFR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source