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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MDM2-FGF18 (FusionGDB2 ID:52404)

Fusion Gene Summary for MDM2-FGF18

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM2-FGF18
Fusion gene ID: 52404
HgeneTgene
Gene symbol

MDM2

FGF18

Gene ID

4193

8817

Gene nameMDM2 proto-oncogenefibroblast growth factor 18
SynonymsACTFS|HDMX|LSKB|hdm2FGF-18|ZFGF5
Cytomap

12q15

5q35.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, humfibroblast growth factor 18
Modification date2020032920200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000478070, ENST00000258148, 
ENST00000258149, ENST00000350057, 
ENST00000462284, ENST00000299252, 
ENST00000348801, ENST00000356290, 
ENST00000360430, ENST00000393410, 
ENST00000393412, ENST00000393413, 
ENST00000428863, ENST00000517852, 
ENST00000540827, ENST00000544125, 
ENST00000544561, ENST00000545204, 
ENST00000274625, 
Fusion gene scores* DoF score39 X 20 X 11=85806 X 5 X 4=120
# samples 475
** MAII scorelog2(47/8580*10)=-4.19024498582191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MDM2 [Title/Abstract] AND FGF18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMDM2(69214154)-FGF18(170883543), # samples:2
Anticipated loss of major functional domain due to fusion event.MDM2-FGF18 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MDM2-FGF18 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922

TgeneFGF18

GO:0001936

regulation of endothelial cell proliferation

16756958

TgeneFGF18

GO:0043406

positive regulation of MAP kinase activity

16756958

TgeneFGF18

GO:1903670

regulation of sprouting angiogenesis

16756958

TgeneFGF18

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

16756958


check buttonFusion gene breakpoints across MDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FGF18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB3A-01AMDM2chr12

69214154

-FGF18chr5

170883543

+
ChimerDB4SARCTCGA-DX-AB3A-01AMDM2chr12

69214154

+FGF18chr5

170883543

+


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Fusion Gene ORF analysis for MDM2-FGF18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000478070ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
In-frameENST00000258148ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
In-frameENST00000258149ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
In-frameENST00000350057ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
In-frameENST00000462284ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000299252ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000348801ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000356290ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000360430ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000393410ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000393412ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000393413ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000428863ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000517852ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000540827ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000544125ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000544561ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+
intron-3CDSENST00000545204ENST00000274625MDM2chr12

69214154

+FGF18chr5

170883543

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000462284MDM2chr1269214154+ENST00000274625FGF18chr5170883543+1745660266736156
ENST00000258149MDM2chr1269214154+ENST00000274625FGF18chr5170883543+1730645251721156
ENST00000258148MDM2chr1269214154+ENST00000274625FGF18chr5170883543+145737214448144
ENST00000350057MDM2chr1269214154+ENST00000274625FGF18chr5170883543+13502650341113

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000462284ENST00000274625MDM2chr1269214154+FGF18chr5170883543+0.0316088720.9683912
ENST00000258149ENST00000274625MDM2chr1269214154+FGF18chr5170883543+0.0266419330.97335804
ENST00000258148ENST00000274625MDM2chr1269214154+FGF18chr5170883543+0.0126697260.9873303
ENST00000350057ENST00000274625MDM2chr1269214154+FGF18chr5170883543+0.0236093510.9763907

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Fusion Genomic Features for MDM2-FGF18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MDM2-FGF18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69214154/chr5:170883543)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+5926_109113437.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+51126_109119498.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+591_101113437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+5111_101119498.0RegionSufficient to promote the mitochondrial pathway of apoptosis

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+59210_215113437.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+59243_301113437.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+15210_2150322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+15243_3010322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+13210_2150266.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+13243_3010266.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+16210_2150322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+16243_3010322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+14210_2150297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+14243_3010297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+13210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+13243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+12210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+12243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+14210_2150271.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+14243_3010271.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+511210_215119498.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+511243_301119498.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+15210_2150297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+15243_3010297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+1526_1090322.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+1326_1090266.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+1626_1090322.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+1426_1090297.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+1326_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+1226_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+1426_1090271.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+1526_1090297.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+59179_185113437.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+59190_202113437.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+59466_473113437.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+15179_1850322.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+15190_2020322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+15466_4730322.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+13179_1850266.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+13190_2020266.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+13466_4730266.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+16179_1850322.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+16190_2020322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+16466_4730322.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+14179_1850297.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+14190_2020297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+14466_4730297.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+13179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+13190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+13466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+12179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+12190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+12466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+14179_1850271.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+14190_2020271.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+14466_4730271.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+511179_185119498.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+511190_202119498.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+511466_473119498.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+15179_1850297.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+15190_2020297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+15466_4730297.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+59210_304113437.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+59242_331113437.0RegionNote=Region II
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+151_1010322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+15210_3040322.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+15242_3310322.0RegionNote=Region II
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+131_1010266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+13210_3040266.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+13242_3310266.0RegionNote=Region II
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+161_1010322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+16210_3040322.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+16242_3310322.0RegionNote=Region II
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+141_1010297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+14210_3040297.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+14242_3310297.0RegionNote=Region II
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+131_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+13210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+13242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+121_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+12210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+12242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+141_1010271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+14210_3040271.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+14242_3310271.0RegionNote=Region II
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+511210_304119498.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+511242_331119498.0RegionNote=Region II
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+151_1010297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+15210_3040297.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+15242_3310297.0RegionNote=Region II
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+59299_328113437.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+59438_479113437.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+15299_3280322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+15438_4790322.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+13299_3280266.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+13438_4790266.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+16299_3280322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+16438_4790322.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+14299_3280297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+14438_4790297.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+13299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+13438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+12299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+12438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+14299_3280271.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+14438_4790271.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+511299_328119498.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+511438_479119498.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+15299_3280297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+15438_4790297.0Zinc fingerRING-type


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Fusion Gene Sequence for MDM2-FGF18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52404_52404_1_MDM2-FGF18_MDM2_chr12_69214154_ENST00000258148_FGF18_chr5_170883543_ENST00000274625_length(transcript)=1457nt_BP=372nt
CGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTC
CAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTA
TGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATG
ATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAG
TCAATCAGCAGGCCCGATGGCACCAGCAAGGAGTGTGTGTTCATCGAGAAGGTTCTGGAGAACAACTACACGGCCCTGATGTCGGCTAAG
TACTCCGGCTGGTACGTGGGCTTCACCAAGAAGGGGCGGCCGCGGAAGGGCCCCAAGACCCGGGAGAACCAGCAGGACGTGCATTTCATG
AAGCGCTACCCCAAGGGGCAGCCGGAGCTTCAGAAGCCCTTCAAGTACACGACGGTGACCAAGAGGTCCCGTCGGATCCGGCCCACACAC
CCTGCCTAGGCCACCCCGCCGCGGCCCCTCAGGTCGCCCTGGCCACACTCACACTCCCAGAAAACTGCATCAGAGGAATATTTTTACATG
AAAAATAAGGAAGAAGCTCTATTTTTGTACATTGTGTTTAAAAGAAGACAAAAACTGAACCAAAACTCTTGGGGGGAGGGGTGATAAGGA
TTTTATTGTTGACTTGAAACCCCCGATGACAAAAGACTCACGCAAAGGGACTGTAGTCAACCCACAGGTGCTTGTCTCTCTCTAGGAACA
GACAACTCTAAACTCGTCCCCAGAGGAGGACTTGAATGAGGAAACCAACACTTTGAGAAACCAAAGTCCTTTTTCCCAAAGGTTCTGAAA
GGAAAAAAAAAAAAAACAAAAAAAAAGAAAAACAAAGAGAAAGTAGTACTCCGCCCACCAACAAACTCCCCCTAACTTTCCCAATCCTCT
GTTCCTGCCCCAAACTCCAACAAAAATCGCTCTCTGGTTTGCAGTCATTTATTTATTGTCCGCTGCAAGCTGCCCCGAGACACCGCGCAG
GGAAGGCGTGCCCCTGGGAATTCTCCGCGCCTCGACCTCCCGACGACAGACGCCTCGTCCAATCATGGTGACCCTGCCTTGCTCGCAGTT
CTGGAGGATGCTGCTATCGACCTTCCGTGACTCACGTGACCTAGTACACCAATGATAAGGGAATATTTTAAAACCAGCTATATTATATAT
ATTATATATATATAAGCTATTTATTTCACCTCTCTGTATATTGCAGTTTCATGAACCAAGTATTACTGCCTCAACAATTAAAAACAACAG

>52404_52404_1_MDM2-FGF18_MDM2_chr12_69214154_ENST00000258148_FGF18_chr5_170883543_ENST00000274625_length(amino acids)=144AA_BP=119
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGD

--------------------------------------------------------------
>52404_52404_2_MDM2-FGF18_MDM2_chr12_69214154_ENST00000258149_FGF18_chr5_170883543_ENST00000274625_length(transcript)=1730nt_BP=645nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATA
CTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAA
ATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAG
TAGTCAATCAGCAGGCCCGATGGCACCAGCAAGGAGTGTGTGTTCATCGAGAAGGTTCTGGAGAACAACTACACGGCCCTGATGTCGGCT
AAGTACTCCGGCTGGTACGTGGGCTTCACCAAGAAGGGGCGGCCGCGGAAGGGCCCCAAGACCCGGGAGAACCAGCAGGACGTGCATTTC
ATGAAGCGCTACCCCAAGGGGCAGCCGGAGCTTCAGAAGCCCTTCAAGTACACGACGGTGACCAAGAGGTCCCGTCGGATCCGGCCCACA
CACCCTGCCTAGGCCACCCCGCCGCGGCCCCTCAGGTCGCCCTGGCCACACTCACACTCCCAGAAAACTGCATCAGAGGAATATTTTTAC
ATGAAAAATAAGGAAGAAGCTCTATTTTTGTACATTGTGTTTAAAAGAAGACAAAAACTGAACCAAAACTCTTGGGGGGAGGGGTGATAA
GGATTTTATTGTTGACTTGAAACCCCCGATGACAAAAGACTCACGCAAAGGGACTGTAGTCAACCCACAGGTGCTTGTCTCTCTCTAGGA
ACAGACAACTCTAAACTCGTCCCCAGAGGAGGACTTGAATGAGGAAACCAACACTTTGAGAAACCAAAGTCCTTTTTCCCAAAGGTTCTG
AAAGGAAAAAAAAAAAAAACAAAAAAAAAGAAAAACAAAGAGAAAGTAGTACTCCGCCCACCAACAAACTCCCCCTAACTTTCCCAATCC
TCTGTTCCTGCCCCAAACTCCAACAAAAATCGCTCTCTGGTTTGCAGTCATTTATTTATTGTCCGCTGCAAGCTGCCCCGAGACACCGCG
CAGGGAAGGCGTGCCCCTGGGAATTCTCCGCGCCTCGACCTCCCGACGACAGACGCCTCGTCCAATCATGGTGACCCTGCCTTGCTCGCA
GTTCTGGAGGATGCTGCTATCGACCTTCCGTGACTCACGTGACCTAGTACACCAATGATAAGGGAATATTTTAAAACCAGCTATATTATA
TATATTATATATATATAAGCTATTTATTTCACCTCTCTGTATATTGCAGTTTCATGAACCAAGTATTACTGCCTCAACAATTAAAAACAA

>52404_52404_2_MDM2-FGF18_MDM2_chr12_69214154_ENST00000258149_FGF18_chr5_170883543_ENST00000274625_length(amino acids)=156AA_BP=131
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ

--------------------------------------------------------------
>52404_52404_3_MDM2-FGF18_MDM2_chr12_69214154_ENST00000350057_FGF18_chr5_170883543_ENST00000274625_length(transcript)=1350nt_BP=265nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGCCCGA
TGGCACCAGCAAGGAGTGTGTGTTCATCGAGAAGGTTCTGGAGAACAACTACACGGCCCTGATGTCGGCTAAGTACTCCGGCTGGTACGT
GGGCTTCACCAAGAAGGGGCGGCCGCGGAAGGGCCCCAAGACCCGGGAGAACCAGCAGGACGTGCATTTCATGAAGCGCTACCCCAAGGG
GCAGCCGGAGCTTCAGAAGCCCTTCAAGTACACGACGGTGACCAAGAGGTCCCGTCGGATCCGGCCCACACACCCTGCCTAGGCCACCCC
GCCGCGGCCCCTCAGGTCGCCCTGGCCACACTCACACTCCCAGAAAACTGCATCAGAGGAATATTTTTACATGAAAAATAAGGAAGAAGC
TCTATTTTTGTACATTGTGTTTAAAAGAAGACAAAAACTGAACCAAAACTCTTGGGGGGAGGGGTGATAAGGATTTTATTGTTGACTTGA
AACCCCCGATGACAAAAGACTCACGCAAAGGGACTGTAGTCAACCCACAGGTGCTTGTCTCTCTCTAGGAACAGACAACTCTAAACTCGT
CCCCAGAGGAGGACTTGAATGAGGAAACCAACACTTTGAGAAACCAAAGTCCTTTTTCCCAAAGGTTCTGAAAGGAAAAAAAAAAAAAAC
AAAAAAAAAGAAAAACAAAGAGAAAGTAGTACTCCGCCCACCAACAAACTCCCCCTAACTTTCCCAATCCTCTGTTCCTGCCCCAAACTC
CAACAAAAATCGCTCTCTGGTTTGCAGTCATTTATTTATTGTCCGCTGCAAGCTGCCCCGAGACACCGCGCAGGGAAGGCGTGCCCCTGG
GAATTCTCCGCGCCTCGACCTCCCGACGACAGACGCCTCGTCCAATCATGGTGACCCTGCCTTGCTCGCAGTTCTGGAGGATGCTGCTAT
CGACCTTCCGTGACTCACGTGACCTAGTACACCAATGATAAGGGAATATTTTAAAACCAGCTATATTATATATATTATATATATATAAGC
TATTTATTTCACCTCTCTGTATATTGCAGTTTCATGAACCAAGTATTACTGCCTCAACAATTAAAAACAACAGACAAATTATTTAAAAAA

>52404_52404_3_MDM2-FGF18_MDM2_chr12_69214154_ENST00000350057_FGF18_chr5_170883543_ENST00000274625_length(amino acids)=113AA_BP=88
MCNTNMSVPTDGAVTTSQIPASEQETLVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQAR

--------------------------------------------------------------
>52404_52404_4_MDM2-FGF18_MDM2_chr12_69214154_ENST00000462284_FGF18_chr5_170883543_ENST00000274625_length(transcript)=1745nt_BP=660nt
GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC
CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC
CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA
GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG
TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC
AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA
TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT
ACAGGAACTTGGTAGTAGTCAATCAGCAGGCCCGATGGCACCAGCAAGGAGTGTGTGTTCATCGAGAAGGTTCTGGAGAACAACTACACG
GCCCTGATGTCGGCTAAGTACTCCGGCTGGTACGTGGGCTTCACCAAGAAGGGGCGGCCGCGGAAGGGCCCCAAGACCCGGGAGAACCAG
CAGGACGTGCATTTCATGAAGCGCTACCCCAAGGGGCAGCCGGAGCTTCAGAAGCCCTTCAAGTACACGACGGTGACCAAGAGGTCCCGT
CGGATCCGGCCCACACACCCTGCCTAGGCCACCCCGCCGCGGCCCCTCAGGTCGCCCTGGCCACACTCACACTCCCAGAAAACTGCATCA
GAGGAATATTTTTACATGAAAAATAAGGAAGAAGCTCTATTTTTGTACATTGTGTTTAAAAGAAGACAAAAACTGAACCAAAACTCTTGG
GGGGAGGGGTGATAAGGATTTTATTGTTGACTTGAAACCCCCGATGACAAAAGACTCACGCAAAGGGACTGTAGTCAACCCACAGGTGCT
TGTCTCTCTCTAGGAACAGACAACTCTAAACTCGTCCCCAGAGGAGGACTTGAATGAGGAAACCAACACTTTGAGAAACCAAAGTCCTTT
TTCCCAAAGGTTCTGAAAGGAAAAAAAAAAAAAACAAAAAAAAAGAAAAACAAAGAGAAAGTAGTACTCCGCCCACCAACAAACTCCCCC
TAACTTTCCCAATCCTCTGTTCCTGCCCCAAACTCCAACAAAAATCGCTCTCTGGTTTGCAGTCATTTATTTATTGTCCGCTGCAAGCTG
CCCCGAGACACCGCGCAGGGAAGGCGTGCCCCTGGGAATTCTCCGCGCCTCGACCTCCCGACGACAGACGCCTCGTCCAATCATGGTGAC
CCTGCCTTGCTCGCAGTTCTGGAGGATGCTGCTATCGACCTTCCGTGACTCACGTGACCTAGTACACCAATGATAAGGGAATATTTTAAA
ACCAGCTATATTATATATATTATATATATATAAGCTATTTATTTCACCTCTCTGTATATTGCAGTTTCATGAACCAAGTATTACTGCCTC

>52404_52404_4_MDM2-FGF18_MDM2_chr12_69214154_ENST00000462284_FGF18_chr5_170883543_ENST00000274625_length(amino acids)=156AA_BP=131
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MDM2-FGF18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+59170_306113.33333333333333437.0MTBP
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+15170_3060.0322.0MTBP
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+13170_3060.0266.0MTBP
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+16170_3060322.0MTBP
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+14170_3060.0297.0MTBP
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+13170_3060219.0MTBP
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+12170_3060.0219.0MTBP
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+14170_3060271.0MTBP
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+511170_306119.33333333333333498.0MTBP
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+15170_3060297.0MTBP
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+59150_230113.33333333333333437.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+15150_2300.0322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+13150_2300.0266.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+16150_2300322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+14150_2300.0297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+13150_2300219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+12150_2300.0219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+14150_2300271.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+511150_230119.33333333333333498.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+15150_2300297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr5:170883543ENST00000258149+59223_232113.33333333333333437.0USP7
HgeneMDM2chr12:69214154chr5:170883543ENST00000299252+15223_2320.0322.0USP7
HgeneMDM2chr12:69214154chr5:170883543ENST00000348801+13223_2320.0266.0USP7
HgeneMDM2chr12:69214154chr5:170883543ENST00000356290+16223_2320322.0USP7
HgeneMDM2chr12:69214154chr5:170883543ENST00000360430+14223_2320.0297.0USP7
HgeneMDM2chr12:69214154chr5:170883543ENST00000393412+13223_2320219.0USP7
HgeneMDM2chr12:69214154chr5:170883543ENST00000393413+12223_2320.0219.0USP7
HgeneMDM2chr12:69214154chr5:170883543ENST00000428863+14223_2320271.0USP7
HgeneMDM2chr12:69214154chr5:170883543ENST00000462284+511223_232119.33333333333333498.0USP7
HgeneMDM2chr12:69214154chr5:170883543ENST00000540827+15223_2320297.0USP7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MDM2-FGF18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MDM2-FGF18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource