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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MDM2-MYRFL (FusionGDB2 ID:52411)

Fusion Gene Summary for MDM2-MYRFL

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM2-MYRFL
Fusion gene ID: 52411
HgeneTgene
Gene symbol

MDM2

MYRFL

Gene ID

4193

196446

Gene nameMDM2 proto-oncogenemyelin regulatory factor like
SynonymsACTFS|HDMX|LSKB|hdm2C12orf15|C12orf28|bcm1377
Cytomap

12q15

12q15

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hummyelin regulatory factor-like protein
Modification date2020032920200322
UniProtAcc.

Q96LU7

Ensembl transtripts involved in fusion geneENST00000350057, ENST00000462284, 
ENST00000258148, ENST00000258149, 
ENST00000299252, ENST00000348801, 
ENST00000356290, ENST00000360430, 
ENST00000393410, ENST00000393412, 
ENST00000393413, ENST00000428863, 
ENST00000478070, ENST00000517852, 
ENST00000540827, ENST00000544125, 
ENST00000544561, ENST00000545204, 
ENST00000299350, ENST00000535034, 
ENST00000547771, ENST00000552032, 
Fusion gene scores* DoF score39 X 20 X 11=858029 X 16 X 7=3248
# samples 4726
** MAII scorelog2(47/8580*10)=-4.19024498582191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/3248*10)=-3.64296810415672
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MDM2 [Title/Abstract] AND MYRFL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMDM2(69218431)-MYRFL(70249060), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check buttonFusion gene breakpoints across MDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYRFL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A3NK-01AMDM2chr12

69218431

+MYRFLchr12

70249060

+
ChimerDB4SARCTCGA-QC-AA9N-01AMDM2chr12

69218431

+MYRFLchr12

70249060

+


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Fusion Gene ORF analysis for MDM2-MYRFL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000350057ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
5CDS-intronENST00000350057ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
5CDS-intronENST00000462284ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
5CDS-intronENST00000462284ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
In-frameENST00000350057ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
In-frameENST00000350057ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
In-frameENST00000462284ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
In-frameENST00000462284ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000258148ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000258148ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000258149ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000258149ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000299252ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000299252ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000348801ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000348801ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000356290ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000356290ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000360430ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000360430ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000393410ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000393410ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000393412ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000393412ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000393413ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000393413ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000428863ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000428863ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000478070ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000478070ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000517852ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000517852ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000540827ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000540827ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000544125ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000544125ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000544561ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000544561ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000545204ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000545204ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000258148ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000258148ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000258149ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000258149ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000299252ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000299252ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000348801ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000348801ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000356290ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000356290ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000360430ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000360430ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000393410ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000393410ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000393412ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000393412ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000393413ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000393413ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000428863ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000428863ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000478070ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000478070ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000517852ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000517852ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000540827ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000540827ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000544125ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000544125ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000544561ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000544561ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000545204ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000545204ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000462284MDM2chr1269218431+ENST00000552032MYRFLchr1270249060+370482526635111081
ENST00000462284MDM2chr1269218431+ENST00000547771MYRFLchr1270249060+404282526634751069
ENST00000350057MDM2chr1269218431+ENST00000552032MYRFLchr1270249060+3309430031161038
ENST00000350057MDM2chr1269218431+ENST00000547771MYRFLchr1270249060+3647430030801026

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000462284ENST00000552032MDM2chr1269218431+MYRFLchr1270249060+0.0003824920.99961746
ENST00000462284ENST00000547771MDM2chr1269218431+MYRFLchr1270249060+0.0001608890.99983907
ENST00000350057ENST00000552032MDM2chr1269218431+MYRFLchr1270249060+0.0002871190.9997129
ENST00000350057ENST00000547771MDM2chr1269218431+MYRFLchr1270249060+0.0001100430.99988997

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Fusion Genomic Features for MDM2-MYRFL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MDM2-MYRFL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69218431/chr12:70249060)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYRFL

Q96LU7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+71126_109174498.0DomainSWIB/MDM2
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+7111_101174498.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMYRFLchr12:69218431chr12:70249060ENST00000552032025543_57515911.0Coiled coilOntology_term=ECO:0000255
TgeneMYRFLchr12:69218431chr12:70249060ENST00000552032025142_40515911.0DNA bindingNDT80
TgeneMYRFLchr12:69218431chr12:70249060ENST00000552032025451_55915911.0DomainPeptidase S74
TgeneMYRFLchr12:69218431chr12:70249060ENST00000552032025628_64815911.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19210_2150437.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19243_3010437.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15210_2150322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15243_3010322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13210_2150266.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13243_3010266.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16210_2150322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16243_3010322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14210_2150297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14243_3010297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14210_2150271.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14243_3010271.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711210_215174498.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711243_301174498.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15210_2150297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15243_3010297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+1926_1090437.0DomainSWIB/MDM2
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+1526_1090322.0DomainSWIB/MDM2
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+1326_1090266.0DomainSWIB/MDM2
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+1626_1090322.0DomainSWIB/MDM2
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+1426_1090297.0DomainSWIB/MDM2
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+1326_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+1226_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+1426_1090271.0DomainSWIB/MDM2
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+1526_1090297.0DomainSWIB/MDM2
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19179_1850437.0MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19190_2020437.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19466_4730437.0MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15179_1850322.0MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15190_2020322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15466_4730322.0MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13179_1850266.0MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13190_2020266.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13466_4730266.0MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16179_1850322.0MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16190_2020322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16466_4730322.0MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14179_1850297.0MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14190_2020297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14466_4730297.0MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14179_1850271.0MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14190_2020271.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14466_4730271.0MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711179_185174498.0MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711190_202174498.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711466_473174498.0MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15179_1850297.0MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15190_2020297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15466_4730297.0MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+191_1010437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19210_3040437.0RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19242_3310437.0RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+151_1010322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15210_3040322.0RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15242_3310322.0RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+131_1010266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13210_3040266.0RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13242_3310266.0RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+161_1010322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16210_3040322.0RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16242_3310322.0RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+141_1010297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14210_3040297.0RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14242_3310297.0RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+131_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+121_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+141_1010271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14210_3040271.0RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14242_3310271.0RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711210_304174498.0RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711242_331174498.0RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+151_1010297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15210_3040297.0RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15242_3310297.0RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19299_3280437.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19438_4790437.0Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15299_3280322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15438_4790322.0Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13299_3280266.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13438_4790266.0Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16299_3280322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16438_4790322.0Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14299_3280297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14438_4790297.0Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14299_3280271.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14438_4790271.0Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711299_328174498.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711438_479174498.0Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15299_3280297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15438_4790297.0Zinc fingerRING-type


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Fusion Gene Sequence for MDM2-MYRFL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52411_52411_1_MDM2-MYRFL_MDM2_chr12_69218431_ENST00000350057_MYRFL_chr12_70249060_ENST00000547771_length(transcript)=3647nt_BP=430nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGCTCAGGGAGCCAATGGTACT
CTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACTTTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGAC
ACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCTGGGAGGACT
CCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAA
ATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTGGGGATAGGT
TGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGAC
TCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGA
CAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTAAACAGTCAT
TATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAG
AAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCAATAGAAATG
TTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATT
TTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACAGCAAATAAT
ATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAGTTCTATCTG
TTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGGCAGCGAGGA
CAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAA
GTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAAAGAATAGCC
CAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATGATTGCCCAG
GAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTCCTCATGGTG
GATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATAGAAGAGTTA
GAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGC
AGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATTTTTCAGGAAAAAGACAGGCGTGTCCTAAT
TGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGCTTAAAAGATCAAGACCGACGTGTCCCAAATCTCCCTCCA
AGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAGCACCTAATACATCCCTGGTAACCACACCGGCCTCC
TTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTATTGCTGCCCCATCCGGGGAATGAAAGAAGTCTCTTCA
AGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCAGACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTC
AGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATTCAGATTATGGAAATCCAGCAAATAATAGATCATCAGTAT
TGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCTGTTAATAAACACACACCCACCAATGTCAAGTTCTCTCTG
GAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTTGGAAATATATGTTTCCATAGTAAAAGGGGAACCAAAGGG
CTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCACATTTGGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATG
TTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCTTATTTTGCTGGGATATTCTTCACCGATTACTTCTTTTAC
TTCTATCGACGCTGTGCCTAATTTGTTCAAGTTTGGGGACTTTACCAAAGAAAAATACTCAGGAATACATTTAACAGAAACGAACATCCT
CTTGCAACTTCTTTTTTCTTCTTTGTAAAACATTTACGTTTATTGCTGAAGGACTTTTTCAGGCTTTAGCTTCCAACAGTTTTGAGACAT
TAATGAGGAGAATAAAATGTTTGCTGAAACTTGAAATAATGTGATGTTTGATTTTGCCATGACTATGAAGAAAACATTTCCTGGAGCAAA
CAGTTCTGTTGAATTTAAAAATACTATTATTTCTGGTATTAAGGAAGTTGTGAGCTCAAAATAAGGAGATCTAGCCTCTATTTTGTTTTA
ATGTATTTTAAAGCTTTTGAAAAAACCAAAAGGGCCATGTCGACTTCGGCCCACTAAACATAGACTCTTGAGAATGTGTGATATGGTATG
TGGAGGAGATGTGGGGGGTGGTATCTGATACTGAGCTCACATTTAGGCAAATTGTCCTATGTGTGTGTGTATTGTATAAACACATACACT

>52411_52411_1_MDM2-MYRFL_MDM2_chr12_69218431_ENST00000350057_MYRFL_chr12_70249060_ENST00000547771_length(amino acids)=1026AA_BP=0
MCNTNMSVPTDGAVTTSQIPASEQETLVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQES
SDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETAQGANGTLENPALDTSLLEEFLGNDFDLGALQRQLPD
TPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQSVSSHLGIG
CSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVPWHSLLNSH
YEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQSQADRSKKI
FNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFENDSDALWQRG
QVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTAHQTGMIAQ
EVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASEASTISKSS
RAVSASSPRRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFCLKDQDRRVPNLPPSNITSSQEPALLPTASSSAPNTSLVTTPAS
LQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRWSDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQY
CIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSM

--------------------------------------------------------------
>52411_52411_2_MDM2-MYRFL_MDM2_chr12_69218431_ENST00000350057_MYRFL_chr12_70249060_ENST00000552032_length(transcript)=3309nt_BP=430nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGCTCAGGGAGCCAATGGTACT
CTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACTTTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGAC
ACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCTGGGAGGACT
CCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAA
ATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTGGGGATAGGT
TGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGAC
TCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGA
CAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTAAACAGTCAT
TATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAG
AAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCAATAGAAATG
TTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATT
TTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACAGCAAATAAT
ATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAGTTCTATCTG
TTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGGCAGCGAGGA
CAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAA
GTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAAAGAATAGCC
CAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATGATTGCCCAG
GAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTCCTCATGGTG
GATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATAGAAGAGTTA
GAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGC
AGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATTTTTCAGGAAAAAGACAGGCGTGTCCTAAT
TGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGTGCTTTGACGATAGTTGCCCTCTATATACTTAGCTTAAAA
GATCAAGACCGACGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAGCA
CCTAATACATCCCTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTATTGC
TGCCCCATCCGGGGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCAGAA
GACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATTCAG
ATTATGGAAATCCAGCAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCTGTT
AATAAACACACACCCACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTTGGA
AATATATGTTTCCATAGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCACATT
TGGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCTTAT
TTTGCTGGGATATTCTTCACCGATTACTTCTTTTACTTCTATCGACGCTGTGCCTAATTTGTTCAAGTTTGGGGACTTTACCAAAGAAAA
ATACTCAGGAATACATTTAACAGAAACGAACATCCTCTTGCAACTTCTTTTTTCTTCTTTGTAAAACATTTACGTTTATTGCTGAAGGAC

>52411_52411_2_MDM2-MYRFL_MDM2_chr12_69218431_ENST00000350057_MYRFL_chr12_70249060_ENST00000552032_length(amino acids)=1038AA_BP=0
MCNTNMSVPTDGAVTTSQIPASEQETLVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQES
SDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETAQGANGTLENPALDTSLLEEFLGNDFDLGALQRQLPD
TPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQSVSSHLGIG
CSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVPWHSLLNSH
YEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQSQADRSKKI
FNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFENDSDALWQRG
QVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTAHQTGMIAQ
EVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASEASTISKSS
RAVSASSPRRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFCALTIVALYILSLKDQDRRVPNLPPSNITSSQEPALLPTASSSA
PNTSLVTTPASLQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRWSEDKSKSVLARNALSGPDWESDWIDTTISSIQ
IMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHI

--------------------------------------------------------------
>52411_52411_3_MDM2-MYRFL_MDM2_chr12_69218431_ENST00000462284_MYRFL_chr12_70249060_ENST00000547771_length(transcript)=4042nt_BP=825nt
GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC
CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC
CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA
GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG
TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC
AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA
TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT
ACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTG
ATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAG
CAATTAGTGAGACAGCTCAGGGAGCCAATGGTACTCTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACT
TTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCAT
GCTACCCAACCCTGAGGCCCACAGCTGGGAGGACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGC
TGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCC
TGGACCAATCCGTGTCCTCCCATCTGGGGATAGGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAA
CCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTC
GCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCC
ATAGTGTTCCTTGGCACAGCTTATTAAACAGTCATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATT
TTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTG
TTGAAACCGAGATGGGCCTAAAGCCAATAGAAATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTA
TTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGG
GACGATTACACTTCAGCGAAACCACAGCAAATAATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTG
GACTGTATGCTGCTAACCAAGACCAGTTCTATCTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGT
TTGAAAATGACAGTGATGCATTGTGGCAGCGAGGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGC
CGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGG
AGGTTGACACGAATGAACAGCTGAAAAGAATAGCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAA
TAAACACTGCCCATCAAACAGGAATGATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCG
GAAACGGAGAGACCTTGGAGAACTTCCTCATGGTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAAC
TAACTAACAACCTTGAGGAAAGAATAGAAGAGTTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCAT
CAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGG
TTTATTTTTCAGGAAAAAGACAGGCGTGTCCTAATTGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGCTTAA
AAGATCAAGACCGACGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAG
CACCTAATACATCCCTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTATT
GCTGCCCCATCCGGGGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCAG
ACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATTCAGA
TTATGGAAATCCAGCAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCTGTTA
ATAAACACACACCCACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTTGGAA
ATATATGTTTCCATAGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCACATTT
GGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCTTATT
TTGCTGGGATATTCTTCACCGATTACTTCTTTTACTTCTATCGACGCTGTGCCTAATTTGTTCAAGTTTGGGGACTTTACCAAAGAAAAA
TACTCAGGAATACATTTAACAGAAACGAACATCCTCTTGCAACTTCTTTTTTCTTCTTTGTAAAACATTTACGTTTATTGCTGAAGGACT
TTTTCAGGCTTTAGCTTCCAACAGTTTTGAGACATTAATGAGGAGAATAAAATGTTTGCTGAAACTTGAAATAATGTGATGTTTGATTTT
GCCATGACTATGAAGAAAACATTTCCTGGAGCAAACAGTTCTGTTGAATTTAAAAATACTATTATTTCTGGTATTAAGGAAGTTGTGAGC
TCAAAATAAGGAGATCTAGCCTCTATTTTGTTTTAATGTATTTTAAAGCTTTTGAAAAAACCAAAAGGGCCATGTCGACTTCGGCCCACT
AAACATAGACTCTTGAGAATGTGTGATATGGTATGTGGAGGAGATGTGGGGGGTGGTATCTGATACTGAGCTCACATTTAGGCAAATTGT

>52411_52411_3_MDM2-MYRFL_MDM2_chr12_69218431_ENST00000462284_MYRFL_chr12_70249060_ENST00000547771_length(amino acids)=1069AA_BP=1
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRR
RAISETAQGANGTLENPALDTSLLEEFLGNDFDLGALQRQLPDTPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMH
PLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQSVSSHLGIGCSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWACHCRPMTSR
SRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVPWHSLLNSHYEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPK
FVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQSQADRSKKIFNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLV
VGLYAANQDQFYLLSAHISERIIVRASNPGQFENDSDALWQRGQVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNI
QEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTAHQTGMIAQEVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLC
KLTNNLEERIEELEIWNRKLARLKRLSSWKSSASEASTISKSSRAVSASSPRRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFC
LKDQDRRVPNLPPSNITSSQEPALLPTASSSAPNTSLVTTPASLQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRW
SDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTL

--------------------------------------------------------------
>52411_52411_4_MDM2-MYRFL_MDM2_chr12_69218431_ENST00000462284_MYRFL_chr12_70249060_ENST00000552032_length(transcript)=3704nt_BP=825nt
GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC
CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC
CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA
GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG
TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC
AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA
TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT
ACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTG
ATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAG
CAATTAGTGAGACAGCTCAGGGAGCCAATGGTACTCTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACT
TTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCAT
GCTACCCAACCCTGAGGCCCACAGCTGGGAGGACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGC
TGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCC
TGGACCAATCCGTGTCCTCCCATCTGGGGATAGGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAA
CCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTC
GCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCC
ATAGTGTTCCTTGGCACAGCTTATTAAACAGTCATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATT
TTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTG
TTGAAACCGAGATGGGCCTAAAGCCAATAGAAATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTA
TTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGG
GACGATTACACTTCAGCGAAACCACAGCAAATAATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTG
GACTGTATGCTGCTAACCAAGACCAGTTCTATCTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGT
TTGAAAATGACAGTGATGCATTGTGGCAGCGAGGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGC
CGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGG
AGGTTGACACGAATGAACAGCTGAAAAGAATAGCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAA
TAAACACTGCCCATCAAACAGGAATGATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCG
GAAACGGAGAGACCTTGGAGAACTTCCTCATGGTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAAC
TAACTAACAACCTTGAGGAAAGAATAGAAGAGTTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCAT
CAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGG
TTTATTTTTCAGGAAAAAGACAGGCGTGTCCTAATTGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGTGCTT
TGACGATAGTTGCCCTCTATATACTTAGCTTAAAAGATCAAGACCGACGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGG
AGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAGCACCTAATACATCCCTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTT
TCTGTGAAATCCTGCCGTGTCAGGAGACTTATTGCTGCCCCATCCGGGGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTG
AGGAGAAGGAATTCCATCAGAGGCGATGGTCAGAAGACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGA
GTGACTGGATTGATACAACCATCAGTTCTATTCAGATTATGGAAATCCAGCAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGT
GCGGATCTGGAAATTATAATTACAATATTCCTGTTAATAAACACACACCCACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGC
CATTGATAGTCTTCCAGTGCAAATTCACCCTTGGAAATATATGTTTCCATAGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAA
TCTCCCAGGAGATGACACAGGGATATCAGCACATTTGGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTG
CACCGGATTTAGCTGACTGTTCAACTGATCCTTATTTTGCTGGGATATTCTTCACCGATTACTTCTTTTACTTCTATCGACGCTGTGCCT
AATTTGTTCAAGTTTGGGGACTTTACCAAAGAAAAATACTCAGGAATACATTTAACAGAAACGAACATCCTCTTGCAACTTCTTTTTTCT
TCTTTGTAAAACATTTACGTTTATTGCTGAAGGACTTTTTCAGGCTTTAGCTTCCAACAGTTTTGAGACATTAATGAGGAGAATAAAATG

>52411_52411_4_MDM2-MYRFL_MDM2_chr12_69218431_ENST00000462284_MYRFL_chr12_70249060_ENST00000552032_length(amino acids)=1081AA_BP=1
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRR
RAISETAQGANGTLENPALDTSLLEEFLGNDFDLGALQRQLPDTPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMH
PLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQSVSSHLGIGCSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWACHCRPMTSR
SRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVPWHSLLNSHYEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPK
FVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQSQADRSKKIFNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLV
VGLYAANQDQFYLLSAHISERIIVRASNPGQFENDSDALWQRGQVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNI
QEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTAHQTGMIAQEVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLC
KLTNNLEERIEELEIWNRKLARLKRLSSWKSSASEASTISKSSRAVSASSPRRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFC
ALTIVALYILSLKDQDRRVPNLPPSNITSSQEPALLPTASSSAPNTSLVTTPASLQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQ
SEEKEFHQRRWSEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTT
EPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYRRC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MDM2-MYRFL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19170_3060437.0MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15170_3060.0322.0MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13170_3060.0266.0MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16170_3060322.0MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14170_3060.0297.0MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13170_3060219.0MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12170_3060.0219.0MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14170_3060271.0MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711170_306174.33333333333334498.0MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15170_3060297.0MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19150_2300437.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15150_2300.0322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13150_2300.0266.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16150_2300322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14150_2300.0297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13150_2300219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12150_2300.0219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14150_2300271.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711150_230174.33333333333334498.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15150_2300297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19223_2320437.0USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15223_2320.0322.0USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13223_2320.0266.0USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16223_2320322.0USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14223_2320.0297.0USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13223_2320219.0USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12223_2320.0219.0USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14223_2320271.0USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711223_232174.33333333333334498.0USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15223_2320297.0USP7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MDM2-MYRFL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MDM2-MYRFL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource