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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MDM2-POLR3B (FusionGDB2 ID:52414)

Fusion Gene Summary for MDM2-POLR3B

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM2-POLR3B
Fusion gene ID: 52414
HgeneTgene
Gene symbol

MDM2

POLR3B

Gene ID

4193

55703

Gene nameMDM2 proto-oncogeneRNA polymerase III subunit B
SynonymsACTFS|HDMX|LSKB|hdm2C128|HLD8|INMAP|RPC2
Cytomap

12q15

12q23.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, humDNA-directed RNA polymerase III subunit RPC2DNA-directed RNA polymerase III 127.6 kDa polypeptideDNA-directed RNA polymerase III subunit BRNA polymerase III subunit C2interphase nucleus and mitotic apparatus associated proteinpolymerase (RNA) III (DN
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000258148, ENST00000258149, 
ENST00000299252, ENST00000350057, 
ENST00000356290, ENST00000360430, 
ENST00000462284, ENST00000540827, 
ENST00000348801, ENST00000393410, 
ENST00000393412, ENST00000393413, 
ENST00000428863, ENST00000478070, 
ENST00000517852, ENST00000544125, 
ENST00000544561, ENST00000545204, 
ENST00000549195, ENST00000228347, 
ENST00000539066, 
Fusion gene scores* DoF score39 X 20 X 11=85802 X 2 X 2=8
# samples 472
** MAII scorelog2(47/8580*10)=-4.19024498582191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: MDM2 [Title/Abstract] AND POLR3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMDM2(69230529)-POLR3B(106820975), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check buttonFusion gene breakpoints across MDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across POLR3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A48N-01AMDM2chr12

69230529

+POLR3Bchr12

106820975

+


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Fusion Gene ORF analysis for MDM2-POLR3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000258148ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
5CDS-3UTRENST00000258149ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
5CDS-3UTRENST00000299252ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
5CDS-3UTRENST00000350057ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
5CDS-3UTRENST00000356290ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
5CDS-3UTRENST00000360430ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
5CDS-3UTRENST00000462284ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
5CDS-3UTRENST00000540827ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000258148ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000258148ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000258149ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000258149ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000299252ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000299252ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000350057ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000350057ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000356290ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000356290ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000360430ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000360430ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000462284ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000462284ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000540827ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
In-frameENST00000540827ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000348801ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000348801ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000393410ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000393410ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000393412ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000393412ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000393413ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000393413ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000428863ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000428863ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000478070ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000478070ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000517852ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000517852ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000544125ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000544125ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000544561ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000544561ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000545204ENST00000228347MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3CDSENST00000545204ENST00000539066MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3UTRENST00000348801ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3UTRENST00000393410ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3UTRENST00000393412ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3UTRENST00000393413ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3UTRENST00000428863ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3UTRENST00000478070ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3UTRENST00000517852ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3UTRENST00000544125ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3UTRENST00000544561ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+
intron-3UTRENST00000545204ENST00000549195MDM2chr12

69230529

+POLR3Bchr12

106820975

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000462284MDM2chr1269230529+ENST00000228347POLR3Bchr12106820975+4170122026635201084
ENST00000462284MDM2chr1269230529+ENST00000539066POLR3Bchr12106820975+4168122026635201084
ENST00000356290MDM2chr1269230529+ENST00000228347POLR3Bchr12106820975+36456952512995914
ENST00000356290MDM2chr1269230529+ENST00000539066POLR3Bchr12106820975+36436952512995914
ENST00000540827MDM2chr1269230529+ENST00000228347POLR3Bchr12106820975+35706202512920889
ENST00000540827MDM2chr1269230529+ENST00000539066POLR3Bchr12106820975+35686202512920889
ENST00000258149MDM2chr1269230529+ENST00000228347POLR3Bchr12106820975+3990104025133401029
ENST00000258149MDM2chr1269230529+ENST00000539066POLR3Bchr12106820975+3988104025133401029
ENST00000258148MDM2chr1269230529+ENST00000228347POLR3Bchr12106820975+37177671430671017
ENST00000258148MDM2chr1269230529+ENST00000539066POLR3Bchr12106820975+37157671430671017
ENST00000350057MDM2chr1269230529+ENST00000228347POLR3Bchr12106820975+3775825031251041
ENST00000350057MDM2chr1269230529+ENST00000539066POLR3Bchr12106820975+3773825031251041
ENST00000360430MDM2chr1269230529+ENST00000228347POLR3Bchr12106820975+326531502615871
ENST00000360430MDM2chr1269230529+ENST00000539066POLR3Bchr12106820975+326331502615871
ENST00000299252MDM2chr1269230529+ENST00000228347POLR3Bchr12106820975+334039002690896
ENST00000299252MDM2chr1269230529+ENST00000539066POLR3Bchr12106820975+333839002690896

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000462284ENST00000228347MDM2chr1269230529+POLR3Bchr12106820975+0.0002129270.99978703
ENST00000462284ENST00000539066MDM2chr1269230529+POLR3Bchr12106820975+0.0002143830.9997856
ENST00000356290ENST00000228347MDM2chr1269230529+POLR3Bchr12106820975+0.0003818640.99961805
ENST00000356290ENST00000539066MDM2chr1269230529+POLR3Bchr12106820975+0.0003853010.9996147
ENST00000540827ENST00000228347MDM2chr1269230529+POLR3Bchr12106820975+0.0003130910.99968696
ENST00000540827ENST00000539066MDM2chr1269230529+POLR3Bchr12106820975+0.000315690.99968433
ENST00000258149ENST00000228347MDM2chr1269230529+POLR3Bchr12106820975+0.0002229260.99977714
ENST00000258149ENST00000539066MDM2chr1269230529+POLR3Bchr12106820975+0.0002237080.9997763
ENST00000258148ENST00000228347MDM2chr1269230529+POLR3Bchr12106820975+0.0001796590.9998204
ENST00000258148ENST00000539066MDM2chr1269230529+POLR3Bchr12106820975+0.0001809110.9998191
ENST00000350057ENST00000228347MDM2chr1269230529+POLR3Bchr12106820975+0.0001675160.9998325
ENST00000350057ENST00000539066MDM2chr1269230529+POLR3Bchr12106820975+0.0001691310.99983084
ENST00000360430ENST00000228347MDM2chr1269230529+POLR3Bchr12106820975+0.0004173550.9995827
ENST00000360430ENST00000539066MDM2chr1269230529+POLR3Bchr12106820975+0.0004211220.9995789
ENST00000299252ENST00000228347MDM2chr1269230529+POLR3Bchr12106820975+0.0003440140.99965596
ENST00000299252ENST00000539066MDM2chr1269230529+POLR3Bchr12106820975+0.0003461510.9996538

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Fusion Genomic Features for MDM2-POLR3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MDM2-POLR3B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69230529/chr12:106820975)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+89210_215245437.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+1011210_215306498.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+1011243_301306498.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+8926_109245437.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+4526_109130322.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+5626_109130322.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+101126_109306498.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+89179_185245437.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+89190_202245437.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+1011179_185306498.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+1011190_202306498.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+891_101245437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+451_101130322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+561_101130322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+341_101105297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+10111_101306498.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+1011210_304306498.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+451_101105297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgenePOLR3Bchr12:69230529chr12:106820975ENST0000022834711281080_10953671134.0Zinc fingerNote=C4-type
TgenePOLR3Bchr12:69230529chr12:106820975ENST0000053906611281080_10953091076.0Zinc fingerNote=C4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+89243_301245437.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+45210_215130322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+45243_301130322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+13210_2150266.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+13243_3010266.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+56210_215130322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+56243_301130322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+34210_215105297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+34243_301105297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+13210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+13243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+12210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+12243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+14210_2150271.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+14243_3010271.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+45210_215105297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+45243_301105297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+1326_1090266.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+3426_109105297.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+1326_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+1226_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+1426_1090271.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+4526_109105297.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+89466_473245437.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+45179_185130322.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+45190_202130322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+45466_473130322.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+13179_1850266.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+13190_2020266.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+13466_4730266.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+56179_185130322.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+56190_202130322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+56466_473130322.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+34179_185105297.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+34190_202105297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+34466_473105297.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+13179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+13190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+13466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+12179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+12190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+12466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+14179_1850271.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+14190_2020271.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+14466_4730271.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+1011466_473306498.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+45179_185105297.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+45190_202105297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+45466_473105297.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+89210_304245437.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+89242_331245437.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+45210_304130322.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+45242_331130322.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+131_1010266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+13210_3040266.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+13242_3310266.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+56210_304130322.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+56242_331130322.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+34210_304105297.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+34242_331105297.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+131_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+13210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+13242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+121_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+12210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+12242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+141_1010271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+14210_3040271.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+14242_3310271.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+1011242_331306498.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+45210_304105297.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+45242_331105297.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+89299_328245437.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+89438_479245437.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+45299_328130322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+45438_479130322.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+13299_3280266.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+13438_4790266.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+56299_328130322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+56438_479130322.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+34299_328105297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+34438_479105297.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+13299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+13438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+12299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+12438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+14299_3280271.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+14438_4790271.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+1011299_328306498.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+1011438_479306498.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+45299_328105297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+45438_479105297.0Zinc fingerRING-type


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Fusion Gene Sequence for MDM2-POLR3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52414_52414_1_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000258148_POLR3B_chr12_106820975_ENST00000228347_length(transcript)=3717nt_BP=767nt
CGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTC
CAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTA
TGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATG
ATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAG
TCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATG
AAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTG
ATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCG
ACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGG
AGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTTAATT
CTGAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACATGCGCCAAGACCAGATCA
CCAATGGCATGGTGAATGCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTGTCTC
GCTTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGAGTGGTCCTCGCTCCCTCC
AGCCATCTCAGTGGGGAATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACACACA
TCACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGGGAAGAGCTCT
CTTACCCAAATGTGTTTCTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGACTCA
TGAGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTTCTTCTGATGGGGGAAGGC
TATGCAGACCCTACATAATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAATTTTG
AAGATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGTACGAACACACAATTAATA
AAGACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCACCGA
GAAACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTGATACTCTCATGTATCTAC
TAGCATATCCACAAAAACCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACAGTTG
CTGTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCTTTGGGCGTTGCCTTGTAT
ATAAAAATGCTAAATGTACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGGAAAC
CTATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAGTGCTTGTAAATAAGTCCA
TGCCCACAGTGACTCAGATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGAGCAA
CAGACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGAGACAGACAAGGCGTCCAG
AAATTGGAGACAAATTCAGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGATTCTG
GCATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGCTGCTGGCTGGCAAGGCCG
GTGTGCTGGACGGCAGATTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGTTATA
ACTACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCCCCGTGTACTATCAGAAGC
TGAAACACATGGTGCTAGATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCTCGTG
ATGGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAGAGAGACTAATGATTTCAA
GTGATGCCTTTGAGGTTGATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCACGTGT
CTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGTACA
ATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTCTCC
TCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAAACA
ACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAAAGG
ATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAATTTA
CCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTGTCG
TGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATAATG
AATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATTGTACCATGCAA

>52414_52414_1_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000258148_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=1017AA_BP=251
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGD
LFGVPSFSVKEHRKIYTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVS
EHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKK
IADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQW
GMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAG
YINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTH
LEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSY
SGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVT
QIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPD
IIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMV
LDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRI

--------------------------------------------------------------
>52414_52414_2_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000258148_POLR3B_chr12_106820975_ENST00000539066_length(transcript)=3715nt_BP=767nt
CGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTC
CAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTA
TGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATG
ATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAG
TCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATG
AAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTG
ATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCG
ACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGG
AGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTTAATT
CTGAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACATGCGCCAAGACCAGATCA
CCAATGGCATGGTGAATGCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTGTCTC
GCTTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGAGTGGTCCTCGCTCCCTCC
AGCCATCTCAGTGGGGAATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACACACA
TCACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGGGAAGAGCTCT
CTTACCCAAATGTGTTTCTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGACTCA
TGAGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTTCTTCTGATGGGGGAAGGC
TATGCAGACCCTACATAATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAATTTTG
AAGATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGTACGAACACACAATTAATA
AAGACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCACCGA
GAAACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTGATACTCTCATGTATCTAC
TAGCATATCCACAAAAACCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACAGTTG
CTGTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCTTTGGGCGTTGCCTTGTAT
ATAAAAATGCTAAATGTACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGGAAAC
CTATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAGTGCTTGTAAATAAGTCCA
TGCCCACAGTGACTCAGATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGAGCAA
CAGACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGAGACAGACAAGGCGTCCAG
AAATTGGAGACAAATTCAGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGATTCTG
GCATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGCTGCTGGCTGGCAAGGCCG
GTGTGCTGGACGGCAGATTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGTTATA
ACTACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCCCCGTGTACTATCAGAAGC
TGAAACACATGGTGCTAGATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCTCGTG
ATGGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAGAGAGACTAATGATTTCAA
GTGATGCCTTTGAGGTTGATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCACGTGT
CTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGTACA
ATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTCTCC
TCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAAACA
ACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAAAGG
ATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAATTTA
CCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTGTCG
TGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATAATG
AATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATTGTACCATGCAA

>52414_52414_2_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000258148_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=1017AA_BP=251
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGD
LFGVPSFSVKEHRKIYTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVS
EHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKK
IADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQW
GMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAG
YINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTH
LEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSY
SGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVT
QIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPD
IIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMV
LDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRI

--------------------------------------------------------------
>52414_52414_3_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000258149_POLR3B_chr12_106820975_ENST00000228347_length(transcript)=3990nt_BP=1040nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATA
CTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAA
ATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAG
TAGTCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTG
ATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATC
TTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTC
TCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAG
GGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTTA
ATTCTGAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACATGCGCCAAGACCAGA
TCACCAATGGCATGGTGAATGCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTGT
CTCGCTTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGAGTGGTCCTCGCTCCC
TCCAGCCATCTCAGTGGGGAATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACAC
ACATCACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGGGAAGAGC
TCTCTTACCCAAATGTGTTTCTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGAC
TCATGAGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTTCTTCTGATGGGGGAA
GGCTATGCAGACCCTACATAATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAATT
TTGAAGATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGTACGAACACACAATTA
ATAAAGACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCAC
CGAGAAACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTGATACTCTCATGTATC
TACTAGCATATCCACAAAAACCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACAG
TTGCTGTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCTTTGGGCGTTGCCTTG
TATATAAAAATGCTAAATGTACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGGA
AACCTATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAGTGCTTGTAAATAAGT
CCATGCCCACAGTGACTCAGATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGAG
CAACAGACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGAGACAGACAAGGCGTC
CAGAAATTGGAGACAAATTCAGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGATT
CTGGCATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGCTGCTGGCTGGCAAGG
CCGGTGTGCTGGACGGCAGATTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGTT
ATAACTACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCCCCGTGTACTATCAGA
AGCTGAAACACATGGTGCTAGATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCTC
GTGATGGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAGAGAGACTAATGATTT
CAAGTGATGCCTTTGAGGTTGATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCACG
TGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGT
ACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTC
TCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAA
ACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAA
AGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAAT
TTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTG
TCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATA
ATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATTGTACCATG

>52414_52414_3_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000258149_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=1029AA_BP=263
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTG
TPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFE
DLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRK
VSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKK
LVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIA
LYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLP
AGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENK
QVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQE
DMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYF
GPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHY

--------------------------------------------------------------
>52414_52414_4_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000258149_POLR3B_chr12_106820975_ENST00000539066_length(transcript)=3988nt_BP=1040nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATA
CTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAA
ATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAG
TAGTCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTG
ATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATC
TTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTC
TCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAG
GGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTTA
ATTCTGAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACATGCGCCAAGACCAGA
TCACCAATGGCATGGTGAATGCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTGT
CTCGCTTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGAGTGGTCCTCGCTCCC
TCCAGCCATCTCAGTGGGGAATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACAC
ACATCACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGGGAAGAGC
TCTCTTACCCAAATGTGTTTCTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGAC
TCATGAGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTTCTTCTGATGGGGGAA
GGCTATGCAGACCCTACATAATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAATT
TTGAAGATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGTACGAACACACAATTA
ATAAAGACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCAC
CGAGAAACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTGATACTCTCATGTATC
TACTAGCATATCCACAAAAACCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACAG
TTGCTGTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCTTTGGGCGTTGCCTTG
TATATAAAAATGCTAAATGTACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGGA
AACCTATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAGTGCTTGTAAATAAGT
CCATGCCCACAGTGACTCAGATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGAG
CAACAGACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGAGACAGACAAGGCGTC
CAGAAATTGGAGACAAATTCAGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGATT
CTGGCATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGCTGCTGGCTGGCAAGG
CCGGTGTGCTGGACGGCAGATTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGTT
ATAACTACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCCCCGTGTACTATCAGA
AGCTGAAACACATGGTGCTAGATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCTC
GTGATGGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAGAGAGACTAATGATTT
CAAGTGATGCCTTTGAGGTTGATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCACG
TGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGT
ACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTC
TCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAA
ACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAA
AGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAAT
TTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTG
TCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATA
ATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATTGTACCATG

>52414_52414_4_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000258149_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=1029AA_BP=263
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTG
TPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFE
DLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRK
VSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKK
LVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIA
LYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLP
AGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENK
QVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQE
DMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYF
GPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHY

--------------------------------------------------------------
>52414_52414_5_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000299252_POLR3B_chr12_106820975_ENST00000228347_length(transcript)=3340nt_BP=390nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGATCTTGATGCTGGTGTAAGTGAA
CATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGC
CTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCA
TTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTTAATTCTGAAATGAAAAAGATT
GCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACATGCGCCAAGACCAGATCACCAATGGCATGGTGAAT
GCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTGTCTCGCTTGTCATATATATCC
GCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGAGTGGTCCTCGCTCCCTCCAGCCATCTCAGTGGGGA
ATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACACACATCACAACTGATATGGAA
GATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGGGAAGAGCTCTCTTACCCAAATGTGTTT
CTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGACTCATGAGAAGAGCAGGATAT
ATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTTCTTCTGATGGGGGAAGGCTATGCAGACCCTACATA
ATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAATTTTGAAGATTTCTTACATGAG
AGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGTACGAACACACAATTAATAAAGACACCACCCACTTG
GAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCACCGAGAAACACTTATCAGTGT
GCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTGATACTCTCATGTATCTACTAGCATATCCACAAAAA
CCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACAGTTGCTGTGATGAGCTATAGT
GGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCTTTGGGCGTTGCCTTGTATATAAAAATGCTAAATGT
ACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGGAAACCTATCTGGCGACATGAA
ATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAGTGCTTGTAAATAAGTCCATGCCCACAGTGACTCAG
ATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGAGCAACAGACTCATATATTGAA
AAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGAGACAGACAAGGCGTCCAGAAATTGGAGACAAATTC
AGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGATTCTGGCATCTGTCCGGACATC
ATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGCTGCTGGCTGGCAAGGCCGGTGTGCTGGACGGCAGA
TTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGTTATAACTACTTGGGGAAAGAC
TATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCCCCGTGTACTATCAGAAGCTGAAACACATGGTGCTA
GATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCTCGTGATGGTGGCTTGCGTCTC
GGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAGAGAGACTAATGATTTCAAGTGATGCCTTTGAGGTT
GATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCACGTGTCTTCCCTCCGTATTCCG
TATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGTACAATGAATGAGGATGGAAA
AAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTCTCCTCCTGTGAAGAATTCCC
TTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAAACAACCTTGATCATTGAGCC
TCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAAAGGATAAATAAGCTATTACT
TATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAATTTACCATATCTTCTGGCTAA
CCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTGTCGTGGTGGCTGGCTCGGAT
AAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATAATGAATTTGTTCCTACCTTG
TCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATTGTACCATGCAATACTATTCGTTAAATAT

>52414_52414_5_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000299252_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=896AA_BP=130
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYS
LSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVN
AISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDME
DGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYI
IVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQC
AMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKC
TLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIE
KVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGR
FHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRL

--------------------------------------------------------------
>52414_52414_6_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000299252_POLR3B_chr12_106820975_ENST00000539066_length(transcript)=3338nt_BP=390nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGATCTTGATGCTGGTGTAAGTGAA
CATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGC
CTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCA
TTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTTAATTCTGAAATGAAAAAGATT
GCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACATGCGCCAAGACCAGATCACCAATGGCATGGTGAAT
GCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTGTCTCGCTTGTCATATATATCC
GCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGAGTGGTCCTCGCTCCCTCCAGCCATCTCAGTGGGGA
ATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACACACATCACAACTGATATGGAA
GATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGGGAAGAGCTCTCTTACCCAAATGTGTTT
CTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGACTCATGAGAAGAGCAGGATAT
ATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTTCTTCTGATGGGGGAAGGCTATGCAGACCCTACATA
ATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAATTTTGAAGATTTCTTACATGAG
AGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGTACGAACACACAATTAATAAAGACACCACCCACTTG
GAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCACCGAGAAACACTTATCAGTGT
GCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTGATACTCTCATGTATCTACTAGCATATCCACAAAAA
CCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACAGTTGCTGTGATGAGCTATAGT
GGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCTTTGGGCGTTGCCTTGTATATAAAAATGCTAAATGT
ACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGGAAACCTATCTGGCGACATGAA
ATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAGTGCTTGTAAATAAGTCCATGCCCACAGTGACTCAG
ATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGAGCAACAGACTCATATATTGAA
AAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGAGACAGACAAGGCGTCCAGAAATTGGAGACAAATTC
AGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGATTCTGGCATCTGTCCGGACATC
ATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGCTGCTGGCTGGCAAGGCCGGTGTGCTGGACGGCAGA
TTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGTTATAACTACTTGGGGAAAGAC
TATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCCCCGTGTACTATCAGAAGCTGAAACACATGGTGCTA
GATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCTCGTGATGGTGGCTTGCGTCTC
GGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAGAGAGACTAATGATTTCAAGTGATGCCTTTGAGGTT
GATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCACGTGTCTTCCCTCCGTATTCCG
TATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGTACAATGAATGAGGATGGAAA
AAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTCTCCTCCTGTGAAGAATTCCC
TTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAAACAACCTTGATCATTGAGCC
TCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAAAGGATAAATAAGCTATTACT
TATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAATTTACCATATCTTCTGGCTAA
CCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTGTCGTGGTGGCTGGCTCGGAT
AAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATAATGAATTTGTTCCTACCTTG
TCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATTGTACCATGCAATACTATTCGTTAAATAT

>52414_52414_6_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000299252_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=896AA_BP=130
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYS
LSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVN
AISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDME
DGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYI
IVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQC
AMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKC
TLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIE
KVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGR
FHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRL

--------------------------------------------------------------
>52414_52414_7_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000350057_POLR3B_chr12_106820975_ENST00000228347_length(transcript)=3775nt_BP=825nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTA
TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA
TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGG
TTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGA
CAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCT
GAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTTAATTCTGAAATGAAAAAGATTGCCGACCAGGTGATT
CCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACATGCGCCAAGACCAGATCACCAATGGCATGGTGAATGCTATTTCTACCGGA
AATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTGTCTCGCTTGTCATATATATCCGCACTGGGCATGATG
ACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGAGTGGTCCTCGCTCCCTCCAGCCATCTCAGTGGGGAATGCTGTGTCCTTCG
GACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACACACATCACAACTGATATGGAAGATGGACCCATTGTT
AAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGGGAAGAGCTCTCTTACCCAAATGTGTTTCTTGTCTTTCTTAAT
GGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGACTCATGAGAAGAGCAGGATATATCAATGAATTTGTT
TCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTTCTTCTGATGGGGGAAGGCTATGCAGACCCTACATAATTGTCAAGAAACAG
AAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAATTTTGAAGATTTCTTACATGAGAGTCTGGTTGAATAT
TTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGTACGAACACACAATTAATAAAGACACCACCCACTTGGAGATTGAACCCTTC
ACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCACCGAGAAACACTTATCAGTGTGCCATGGGGAAACAA
GCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTGATACTCTCATGTATCTACTAGCATATCCACAAAAACCCATGGTTAAGACA
AAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACAGTTGCTGTGATGAGCTATAGTGGCTATGATATTGAA
GATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCTTTGGGCGTTGCCTTGTATATAAAAATGCTAAATGTACGTTGAAACGATAC
ACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGGAAACCTATCTGGCGACATGAAATCTTAGATGCAGAT
GGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAGTGCTTGTAAATAAGTCCATGCCCACAGTGACTCAGATTCCTTTGGAAGGA
AGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGAGCAACAGACTCATATATTGAAAAAGTGATGATATCT
TCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGAGACAGACAAGGCGTCCAGAAATTGGAGACAAATTCAGCAGTCGTCATGGG
CAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGATTCTGGCATCTGTCCGGACATCATCATGAACCCACAC
GGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGCTGCTGGCTGGCAAGGCCGGTGTGCTGGACGGCAGATTCCACTACGGCACT
GCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGTTATAACTACTTGGGGAAAGACTATGTTACATCCGGC
ATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCCCCGTGTACTATCAGAAGCTGAAACACATGGTGCTAGATAAAATGCATGCC
CGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCTCGTGATGGTGGCTTGCGTCTCGGGGAAATGGAACGT
GACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAGAGAGACTAATGATTTCAAGTGATGCCTTTGAGGTTGATGTCTGTGGGCAG
TGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCACGTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTG
CTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGTACAATGAATGAGGATGGAAAAAATGATTATTAAAG
AGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTCTCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCT
CTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAAACAACCTTGATCATTGAGCCTCGAGCCATGGGAGA
GATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAAAGGATAAATAAGCTATTACTTATGTGCTGATCTCT
TGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAATTTACCATATCTTCTGGCTAACCATATTCAAGATTC
TTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTGTCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAA
TTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATAATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTC

>52414_52414_7_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000350057_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=1041AA_BP=275
MCNTNMSVPTDGAVTTSQIPASEQETLVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQES
SDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREI
CCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDP
EISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMM
TRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLN
GNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEY
LDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKT
KTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDAD
GICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHG
QKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSG
ITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQ

--------------------------------------------------------------
>52414_52414_8_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000350057_POLR3B_chr12_106820975_ENST00000539066_length(transcript)=3773nt_BP=825nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTA
TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA
TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGG
TTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGA
CAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCT
GAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTTAATTCTGAAATGAAAAAGATTGCCGACCAGGTGATT
CCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACATGCGCCAAGACCAGATCACCAATGGCATGGTGAATGCTATTTCTACCGGA
AATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTGTCTCGCTTGTCATATATATCCGCACTGGGCATGATG
ACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGAGTGGTCCTCGCTCCCTCCAGCCATCTCAGTGGGGAATGCTGTGTCCTTCG
GACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACACACATCACAACTGATATGGAAGATGGACCCATTGTT
AAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGGGAAGAGCTCTCTTACCCAAATGTGTTTCTTGTCTTTCTTAAT
GGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGACTCATGAGAAGAGCAGGATATATCAATGAATTTGTT
TCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTTCTTCTGATGGGGGAAGGCTATGCAGACCCTACATAATTGTCAAGAAACAG
AAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAATTTTGAAGATTTCTTACATGAGAGTCTGGTTGAATAT
TTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGTACGAACACACAATTAATAAAGACACCACCCACTTGGAGATTGAACCCTTC
ACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCACCGAGAAACACTTATCAGTGTGCCATGGGGAAACAA
GCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTGATACTCTCATGTATCTACTAGCATATCCACAAAAACCCATGGTTAAGACA
AAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACAGTTGCTGTGATGAGCTATAGTGGCTATGATATTGAA
GATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCTTTGGGCGTTGCCTTGTATATAAAAATGCTAAATGTACGTTGAAACGATAC
ACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGGAAACCTATCTGGCGACATGAAATCTTAGATGCAGAT
GGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAGTGCTTGTAAATAAGTCCATGCCCACAGTGACTCAGATTCCTTTGGAAGGA
AGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGAGCAACAGACTCATATATTGAAAAAGTGATGATATCT
TCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGAGACAGACAAGGCGTCCAGAAATTGGAGACAAATTCAGCAGTCGTCATGGG
CAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGATTCTGGCATCTGTCCGGACATCATCATGAACCCACAC
GGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGCTGCTGGCTGGCAAGGCCGGTGTGCTGGACGGCAGATTCCACTACGGCACT
GCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGTTATAACTACTTGGGGAAAGACTATGTTACATCCGGC
ATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCCCCGTGTACTATCAGAAGCTGAAACACATGGTGCTAGATAAAATGCATGCC
CGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCTCGTGATGGTGGCTTGCGTCTCGGGGAAATGGAACGT
GACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAGAGAGACTAATGATTTCAAGTGATGCCTTTGAGGTTGATGTCTGTGGGCAG
TGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCACGTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTG
CTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGTACAATGAATGAGGATGGAAAAAATGATTATTAAAG
AGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTCTCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCT
CTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAAACAACCTTGATCATTGAGCCTCGAGCCATGGGAGA
GATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAAAGGATAAATAAGCTATTACTTATGTGCTGATCTCT
TGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAATTTACCATATCTTCTGGCTAACCATATTCAAGATTC
TTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTGTCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAA
TTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATAATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTC

>52414_52414_8_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000350057_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=1041AA_BP=275
MCNTNMSVPTDGAVTTSQIPASEQETLVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQES
SDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREI
CCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDP
EISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMM
TRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLN
GNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEY
LDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKT
KTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDAD
GICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHG
QKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSG
ITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQ

--------------------------------------------------------------
>52414_52414_9_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000356290_POLR3B_chr12_106820975_ENST00000228347_length(transcript)=3645nt_BP=695nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATA
CTATGAAAGAGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAAT
TTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTA
CTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACT
TGTTCAAAAAATTTAATTCTGAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACA
TGCGCCAAGACCAGATCACCAATGGCATGGTGAATGCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTG
TAACCCAAGTGCTGTCTCGCTTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGA
GTGGTCCTCGCTCCCTCCAGCCATCTCAGTGGGGAATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACT
TGGCCCTTATGACACACATCACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTAT
TATGTGGGGAAGAGCTCTCTTACCCAAATGTGTTTCTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAG
TGAATACATTTCGACTCATGAGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTT
CTTCTGATGGGGGAAGGCTATGCAGACCCTACATAATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCC
AAGGGTACAGGAATTTTGAAGATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGT
ACGAACACACAATTAATAAAGACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTC
ACCATAACCAGTCACCGAGAAACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTG
ATACTCTCATGTATCTACTAGCATATCCACAAAAACCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTG
GACAGAATGCAACAGTTGCTGTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCT
TTGGGCGTTGCCTTGTATATAAAAATGCTAAATGTACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGG
ATGCTGCTACAAGGAAACCTATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAG
TGCTTGTAAATAAGTCCATGCCCACAGTGACTCAGATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCA
TAACCTACAAAGGAGCAACAGACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGA
GACAGACAAGGCGTCCAGAAATTGGAGACAAATTCAGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACA
TGCCATTTTGTGATTCTGGCATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGC
TGCTGGCTGGCAAGGCCGGTGTGCTGGACGGCAGATTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACC
TCGTTCGCCATGGTTATAACTACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCC
CCGTGTACTATCAGAAGCTGAAACACATGGTGCTAGATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCA
CTGAAGGACGGTCTCGTGATGGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAG
AGAGACTAATGATTTCAAGTGATGCCTTTGAGGTTGATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCA
AGTCATCCTGCCACGTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGT
TAAAACTGTCCAAGTACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGG
ATTTAGGACTACGTCTCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATAC
TCTAAGACTGGCTAAACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAG
ATGGATGTGACCTAAAGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAA
TGTTTGGGGTCAAATTTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGG
TCAGCCTGGCTTTTGTCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAG
TCTTGGTGAAATATAATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTG

>52414_52414_9_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000356290_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=914AA_BP=148
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVS
DQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQ
FDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEA
CGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLT
DRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCA
GLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNK
ASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQP
QYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMT
VGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRA
VLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQS

--------------------------------------------------------------
>52414_52414_10_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000356290_POLR3B_chr12_106820975_ENST00000539066_length(transcript)=3643nt_BP=695nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATA
CTATGAAAGAGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAAT
TTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTA
CTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACT
TGTTCAAAAAATTTAATTCTGAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACA
TGCGCCAAGACCAGATCACCAATGGCATGGTGAATGCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTG
TAACCCAAGTGCTGTCTCGCTTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGA
GTGGTCCTCGCTCCCTCCAGCCATCTCAGTGGGGAATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACT
TGGCCCTTATGACACACATCACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTAT
TATGTGGGGAAGAGCTCTCTTACCCAAATGTGTTTCTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAG
TGAATACATTTCGACTCATGAGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTT
CTTCTGATGGGGGAAGGCTATGCAGACCCTACATAATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCC
AAGGGTACAGGAATTTTGAAGATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGT
ACGAACACACAATTAATAAAGACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTC
ACCATAACCAGTCACCGAGAAACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTG
ATACTCTCATGTATCTACTAGCATATCCACAAAAACCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTG
GACAGAATGCAACAGTTGCTGTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCT
TTGGGCGTTGCCTTGTATATAAAAATGCTAAATGTACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGG
ATGCTGCTACAAGGAAACCTATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAG
TGCTTGTAAATAAGTCCATGCCCACAGTGACTCAGATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCA
TAACCTACAAAGGAGCAACAGACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGA
GACAGACAAGGCGTCCAGAAATTGGAGACAAATTCAGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACA
TGCCATTTTGTGATTCTGGCATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGC
TGCTGGCTGGCAAGGCCGGTGTGCTGGACGGCAGATTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACC
TCGTTCGCCATGGTTATAACTACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCC
CCGTGTACTATCAGAAGCTGAAACACATGGTGCTAGATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCA
CTGAAGGACGGTCTCGTGATGGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAG
AGAGACTAATGATTTCAAGTGATGCCTTTGAGGTTGATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCA
AGTCATCCTGCCACGTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGT
TAAAACTGTCCAAGTACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGG
ATTTAGGACTACGTCTCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATAC
TCTAAGACTGGCTAAACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAG
ATGGATGTGACCTAAAGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAA
TGTTTGGGGTCAAATTTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGG
TCAGCCTGGCTTTTGTCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAG
TCTTGGTGAAATATAATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTG

>52414_52414_10_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000356290_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=914AA_BP=148
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVS
DQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQ
FDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEA
CGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLT
DRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCA
GLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNK
ASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQP
QYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMT
VGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRA
VLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQS

--------------------------------------------------------------
>52414_52414_11_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000360430_POLR3B_chr12_106820975_ENST00000228347_length(transcript)=3265nt_BP=315nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGATCTTGAT
GCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGAC
TCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAG
AGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTTAATTCT
GAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACATGCGCCAAGACCAGATCACC
AATGGCATGGTGAATGCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTGTCTCGC
TTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGAGTGGTCCTCGCTCCCTCCAG
CCATCTCAGTGGGGAATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACACACATC
ACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGGGAAGAGCTCTCT
TACCCAAATGTGTTTCTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGACTCATG
AGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTTCTTCTGATGGGGGAAGGCTA
TGCAGACCCTACATAATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAATTTTGAA
GATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGTACGAACACACAATTAATAAA
GACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCACCGAGA
AACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTGATACTCTCATGTATCTACTA
GCATATCCACAAAAACCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACAGTTGCT
GTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCTTTGGGCGTTGCCTTGTATAT
AAAAATGCTAAATGTACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGGAAACCT
ATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAGTGCTTGTAAATAAGTCCATG
CCCACAGTGACTCAGATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGAGCAACA
GACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGAGACAGACAAGGCGTCCAGAA
ATTGGAGACAAATTCAGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGATTCTGGC
ATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGCTGCTGGCTGGCAAGGCCGGT
GTGCTGGACGGCAGATTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGTTATAAC
TACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCCCCGTGTACTATCAGAAGCTG
AAACACATGGTGCTAGATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCTCGTGAT
GGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAGAGAGACTAATGATTTCAAGT
GATGCCTTTGAGGTTGATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCACGTGTCT
TCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGTACAAT
GAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTCTCCTC
CTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAAACAAC
CTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAAAGGAT
AAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAATTTACC
ATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTGTCGTG
GTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATAATGAA
TTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATTGTACCATGCAATA

>52414_52414_11_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000360430_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=871AA_BP=105
MCNTNMSVPTDGAVTTSQIPASEQETLDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGE
SDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSR
LSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELS
YPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFE
DFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLL
AYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKP
IWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPE
IGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYN
YLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISS

--------------------------------------------------------------
>52414_52414_12_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000360430_POLR3B_chr12_106820975_ENST00000539066_length(transcript)=3263nt_BP=315nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGATCTTGAT
GCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGAC
TCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAG
AGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTTAATTCT
GAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACATGCGCCAAGACCAGATCACC
AATGGCATGGTGAATGCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTGTCTCGC
TTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGAGTGGTCCTCGCTCCCTCCAG
CCATCTCAGTGGGGAATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACACACATC
ACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGGGAAGAGCTCTCT
TACCCAAATGTGTTTCTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGACTCATG
AGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTTCTTCTGATGGGGGAAGGCTA
TGCAGACCCTACATAATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAATTTTGAA
GATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGTACGAACACACAATTAATAAA
GACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCACCGAGA
AACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTGATACTCTCATGTATCTACTA
GCATATCCACAAAAACCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACAGTTGCT
GTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCTTTGGGCGTTGCCTTGTATAT
AAAAATGCTAAATGTACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGGAAACCT
ATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAGTGCTTGTAAATAAGTCCATG
CCCACAGTGACTCAGATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGAGCAACA
GACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGAGACAGACAAGGCGTCCAGAA
ATTGGAGACAAATTCAGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGATTCTGGC
ATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGCTGCTGGCTGGCAAGGCCGGT
GTGCTGGACGGCAGATTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGTTATAAC
TACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCCCCGTGTACTATCAGAAGCTG
AAACACATGGTGCTAGATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCTCGTGAT
GGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAGAGAGACTAATGATTTCAAGT
GATGCCTTTGAGGTTGATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCACGTGTCT
TCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGTACAAT
GAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTCTCCTC
CTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAAACAAC
CTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAAAGGAT
AAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAATTTACC
ATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTGTCGTG
GTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATAATGAA
TTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATTGTACCATGCAATA

>52414_52414_12_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000360430_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=871AA_BP=105
MCNTNMSVPTDGAVTTSQIPASEQETLDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGE
SDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSR
LSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELS
YPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFE
DFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLL
AYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKP
IWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPE
IGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYN
YLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISS

--------------------------------------------------------------
>52414_52414_13_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000462284_POLR3B_chr12_106820975_ENST00000228347_length(transcript)=4170nt_BP=1220nt
GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC
CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC
CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA
GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG
TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC
AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA
TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT
ACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTG
ATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAG
CAATTAGTGAGACAGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTG
ATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATC
TTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTC
TCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAG
GGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTTA
ATTCTGAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACATGCGCCAAGACCAGA
TCACCAATGGCATGGTGAATGCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTGT
CTCGCTTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGAGTGGTCCTCGCTCCC
TCCAGCCATCTCAGTGGGGAATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACAC
ACATCACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGGGAAGAGC
TCTCTTACCCAAATGTGTTTCTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGAC
TCATGAGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTTCTTCTGATGGGGGAA
GGCTATGCAGACCCTACATAATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAATT
TTGAAGATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGTACGAACACACAATTA
ATAAAGACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCAC
CGAGAAACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTGATACTCTCATGTATC
TACTAGCATATCCACAAAAACCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACAG
TTGCTGTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCTTTGGGCGTTGCCTTG
TATATAAAAATGCTAAATGTACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGGA
AACCTATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAGTGCTTGTAAATAAGT
CCATGCCCACAGTGACTCAGATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGAG
CAACAGACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGAGACAGACAAGGCGTC
CAGAAATTGGAGACAAATTCAGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGATT
CTGGCATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGCTGCTGGCTGGCAAGG
CCGGTGTGCTGGACGGCAGATTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGTT
ATAACTACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCCCCGTGTACTATCAGA
AGCTGAAACACATGGTGCTAGATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCTC
GTGATGGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAGAGAGACTAATGATTT
CAAGTGATGCCTTTGAGGTTGATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCACG
TGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGT
ACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTC
TCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAA
ACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAA
AGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAAT
TTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTG
TCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATA
ATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATTGTACCATG

>52414_52414_13_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000462284_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=1084AA_BP=318
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRR
RAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
SLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQD
QITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALM
THITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDG
GRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQ
SPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRC
LVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYK
GATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAG
KAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGR
SRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLS

--------------------------------------------------------------
>52414_52414_14_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000462284_POLR3B_chr12_106820975_ENST00000539066_length(transcript)=4168nt_BP=1220nt
GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC
CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC
CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA
GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG
TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC
AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA
TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT
ACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTG
ATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAG
CAATTAGTGAGACAGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTG
ATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATC
TTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTC
TCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAG
GGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTTA
ATTCTGAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTGATGTTGTCAAACACATGCGCCAAGACCAGA
TCACCAATGGCATGGTGAATGCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTGT
CTCGCTTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAAAAACGAGAAAAGTGAGTGGTCCTCGCTCCC
TCCAGCCATCTCAGTGGGGAATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACAC
ACATCACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGGGAAGAGC
TCTCTTACCCAAATGTGTTTCTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGAC
TCATGAGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATCGATGTGTCTATATTTCTTCTGATGGGGGAA
GGCTATGCAGACCCTACATAATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAATT
TTGAAGATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATTGTAACATTGCACTGTACGAACACACAATTA
ATAAAGACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCAC
CGAGAAACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACCAGCGAAACAGAATTGATACTCTCATGTATC
TACTAGCATATCCACAAAAACCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACAG
TTGCTGTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCTCTTTAGACAGAGGCTTTGGGCGTTGCCTTG
TATATAAAAATGCTAAATGTACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGGA
AACCTATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAACAAGTGCTTGTAAATAAGT
CCATGCCCACAGTGACTCAGATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGAG
CAACAGACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGATCAAAATGCTGCTGAGACAGACAAGGCGTC
CAGAAATTGGAGACAAATTCAGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGATT
CTGGCATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGGGGAAGCTCATTGAGCTGCTGGCTGGCAAGG
CCGGTGTGCTGGACGGCAGATTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGTT
ATAACTACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCATACATCTATTTTGGCCCCGTGTACTATCAGA
AGCTGAAACACATGGTGCTAGATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCTC
GTGATGGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCAGTATGCTTTTGCTAGAGAGACTAATGATTT
CAAGTGATGCCTTTGAGGTTGATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCACG
TGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGT
ACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTC
TCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAA
ACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAA
AGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAAT
TTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTG
TCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATA
ATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATTGTACCATG

>52414_52414_14_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000462284_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=1084AA_BP=318
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRR
RAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
SLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQD
QITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALM
THITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDG
GRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQ
SPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRC
LVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYK
GATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAG
KAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGR
SRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLS

--------------------------------------------------------------
>52414_52414_15_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000540827_POLR3B_chr12_106820975_ENST00000228347_length(transcript)=3570nt_BP=620nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATC
AGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATG
AGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTC
TTCTTTTTGAAGACTTGTTCAAAAAATTTAATTCTGAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTG
ATGTTGTCAAACACATGCGCCAAGACCAGATCACCAATGGCATGGTGAATGCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAA
TGGACCGCCAGGGTGTAACCCAAGTGCTGTCTCGCTTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAA
AAACGAGAAAAGTGAGTGGTCCTCGCTCCCTCCAGCCATCTCAGTGGGGAATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTG
GTTTGGTTAAAAACTTGGCCCTTATGACACACATCACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAG
AAGATGTGAATTTATTATGTGGGGAAGAGCTCTCTTACCCAAATGTGTTTCTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAG
ACCACAAAAAGCTAGTGAATACATTTCGACTCATGAGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATC
GATGTGTCTATATTTCTTCTGATGGGGGAAGGCTATGCAGACCCTACATAATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATA
TGGAAGAGCTGGCCCAAGGGTACAGGAATTTTGAAGATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATT
GTAACATTGCACTGTACGAACACACAATTAATAAAGACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGAC
TTATCCCATACCCTCACCATAACCAGTCACCGAGAAACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACC
AGCGAAACAGAATTGATACTCTCATGTATCTACTAGCATATCCACAAAAACCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTG
AGAAACTGCCAGCTGGACAGAATGCAACAGTTGCTGTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCT
CTTTAGACAGAGGCTTTGGGCGTTGCCTTGTATATAAAAATGCTAAATGTACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGA
TGGGGCCCATGTTGGATGCTGCTACAAGGAAACCTATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAG
TAGAAAACAAACAAGTGCTTGTAAATAAGTCCATGCCCACAGTGACTCAGATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGT
ACAAAGATGTACCCATAACCTACAAAGGAGCAACAGACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGA
TCAAAATGCTGCTGAGACAGACAAGGCGTCCAGAAATTGGAGACAAATTCAGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCG
TCCCCCAGGAAGACATGCCATTTTGTGATTCTGGCATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGG
GGAAGCTCATTGAGCTGCTGGCTGGCAAGGCCGGTGTGCTGGACGGCAGATTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGG
ATGTGTGTGAGGACCTCGTTCGCCATGGTTATAACTACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCAT
ACATCTATTTTGGCCCCGTGTACTATCAGAAGCTGAAACACATGGTGCTAGATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCC
TTACCAGGCAACCCACTGAAGGACGGTCTCGTGATGGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCA
GTATGCTTTTGCTAGAGAGACTAATGATTTCAAGTGATGCCTTTGAGGTTGATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCT
GGTGCCATTACTGCAAGTCATCCTGCCACGTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGA
ACATCATCCCCAGGTTAAAACTGTCCAAGTACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAA
CGGAAAGCAGAAGGGATTTAGGACTACGTCTCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAG
AGGCTTTTTATATACTCTAAGACTGGCTAAACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGG
CTGCTTGATTCACAGATGGATGTGACCTAAAGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTT
ACTCCTTCAAGCAAATGTTTGGGGTCAAATTTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGA
ATCCATTTGATTTGGTCAGCCTGGCTTTTGTCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAA
ACTTTGTAATTTTAGTCTTGGTGAAATATAATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCT

>52414_52414_15_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000540827_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=889AA_BP=123
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQE
LSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNW
SLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKL
ASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKP
AVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAM
GTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTN
QTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSN
AEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAF
GGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDC

--------------------------------------------------------------
>52414_52414_16_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000540827_POLR3B_chr12_106820975_ENST00000539066_length(transcript)=3568nt_BP=620nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATC
AGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATG
AGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTCTTTTATCTC
TTCTTTTTGAAGACTTGTTCAAAAAATTTAATTCTGAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTTG
ATGTTGTCAAACACATGCGCCAAGACCAGATCACCAATGGCATGGTGAATGCTATTTCTACCGGAAATTGGTCTTTAAAGAGATTTAAAA
TGGACCGCCAGGGTGTAACCCAAGTGCTGTCTCGCTTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAAA
AAACGAGAAAAGTGAGTGGTCCTCGCTCCCTCCAGCCATCTCAGTGGGGAATGCTGTGTCCTTCGGACACTCCTGAAGGAGAGGCATGTG
GTTTGGTTAAAAACTTGGCCCTTATGACACACATCACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTAG
AAGATGTGAATTTATTATGTGGGGAAGAGCTCTCTTACCCAAATGTGTTTCTTGTCTTTCTTAATGGTAACATCTTAGGTGTCATTCGAG
ACCACAAAAAGCTAGTGAATACATTTCGACTCATGAGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGATC
GATGTGTCTATATTTCTTCTGATGGGGGAAGGCTATGCAGACCCTACATAATTGTCAAGAAACAGAAGCCAGCAGTCACAAATAAACATA
TGGAAGAGCTGGCCCAAGGGTACAGGAATTTTGAAGATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGATT
GTAACATTGCACTGTACGAACACACAATTAATAAAGACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGCGTGTGTGCTGGAC
TTATCCCATACCCTCACCATAACCAGTCACCGAGAAACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAACC
AGCGAAACAGAATTGATACTCTCATGTATCTACTAGCATATCCACAAAAACCCATGGTTAAGACAAAAACCATTGAATTGATAGAATTTG
AGAAACTGCCAGCTGGACAGAATGCAACAGTTGCTGTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCCT
CTTTAGACAGAGGCTTTGGGCGTTGCCTTGTATATAAAAATGCTAAATGTACGTTGAAACGATACACCAATCAGACTTTTGATAAAGTGA
TGGGGCCCATGTTGGATGCTGCTACAAGGAAACCTATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAAG
TAGAAAACAAACAAGTGCTTGTAAATAAGTCCATGCCCACAGTGACTCAGATTCCTTTGGAAGGAAGTAATGTACCACAGCAACCACAGT
ACAAAGATGTACCCATAACCTACAAAGGAGCAACAGACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTGA
TCAAAATGCTGCTGAGACAGACAAGGCGTCCAGAAATTGGAGACAAATTCAGCAGTCGTCATGGGCAAAAAGGTGTTTGTGGCTTGATCG
TCCCCCAGGAAGACATGCCATTTTGTGATTCTGGCATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTGG
GGAAGCTCATTGAGCTGCTGGCTGGCAAGGCCGGTGTGCTGGACGGCAGATTCCACTACGGCACTGCGTTTGGAGGCAGTAAAGTGAAGG
ATGTGTGTGAGGACCTCGTTCGCCATGGTTATAACTACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCAT
ACATCTATTTTGGCCCCGTGTACTATCAGAAGCTGAAACACATGGTGCTAGATAAAATGCATGCCCGGGCCCGGGGCCCACGAGCCGTCC
TTACCAGGCAACCCACTGAAGGACGGTCTCGTGATGGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCCA
GTATGCTTTTGCTAGAGAGACTAATGATTTCAAGTGATGCCTTTGAGGTTGATGTCTGTGGGCAGTGTGGACTTCTGGGGTATTCTGGCT
GGTGCCATTACTGCAAGTCATCCTGCCACGTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGA
ACATCATCCCCAGGTTAAAACTGTCCAAGTACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAA
CGGAAAGCAGAAGGGATTTAGGACTACGTCTCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAG
AGGCTTTTTATATACTCTAAGACTGGCTAAACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGG
CTGCTTGATTCACAGATGGATGTGACCTAAAGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTT
ACTCCTTCAAGCAAATGTTTGGGGTCAAATTTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGA
ATCCATTTGATTTGGTCAGCCTGGCTTTTGTCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAA
ACTTTGTAATTTTAGTCTTGGTGAAATATAATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCT

>52414_52414_16_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000540827_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=889AA_BP=123
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQE
LSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNW
SLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKL
ASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKP
AVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAM
GTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTN
QTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSN
AEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAF
GGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDC

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Fusion Gene PPI Analysis for MDM2-POLR3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+1011170_306306.0498.0MTBP
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+89150_230245.0437.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+1011150_230306.0498.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+89223_232245.0437.0USP7
HgeneMDM2chr12:69230529chr12:106820975ENST00000462284+1011223_232306.0498.0USP7


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMDM2chr12:69230529chr12:106820975ENST00000258149+89170_306245.0437.0MTBP
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+45170_306130.0322.0MTBP
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+13170_3060.0266.0MTBP
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+56170_306130.0322.0MTBP
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+34170_306105.0297.0MTBP
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+13170_3060219.0MTBP
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+12170_3060.0219.0MTBP
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+14170_3060271.0MTBP
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+45170_306105.0297.0MTBP
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+45150_230130.0322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+13150_2300.0266.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+56150_230130.0322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+34150_230105.0297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+13150_2300219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+12150_2300.0219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+14150_2300271.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+45150_230105.0297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:106820975ENST00000299252+45223_232130.0322.0USP7
HgeneMDM2chr12:69230529chr12:106820975ENST00000348801+13223_2320.0266.0USP7
HgeneMDM2chr12:69230529chr12:106820975ENST00000356290+56223_232130.0322.0USP7
HgeneMDM2chr12:69230529chr12:106820975ENST00000360430+34223_232105.0297.0USP7
HgeneMDM2chr12:69230529chr12:106820975ENST00000393412+13223_2320219.0USP7
HgeneMDM2chr12:69230529chr12:106820975ENST00000393413+12223_2320.0219.0USP7
HgeneMDM2chr12:69230529chr12:106820975ENST00000428863+14223_2320271.0USP7
HgeneMDM2chr12:69230529chr12:106820975ENST00000540827+45223_232105.0297.0USP7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MDM2-POLR3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MDM2-POLR3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource